phenytoin has been researched along with Hypoalbuminemia in 11 studies
Hypoalbuminemia: A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (ALBUMINURIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty critically ill pediatric patients receiving phenytoin for treatment of seizures in a large multidisciplinary intensive care unit." | 3.73 | Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children. ( Dodson, B; McClain, CD; McManus, ML; Wolf, GK; Zurakowski, D, 2006) |
| "Because hypoalbuminemia is common in the ICU setting, inappropriate ordering of serum albumin levels may lead to unnecessary albumin administration or excessive macronutrient administration in nutritional regimens, leading to possible adverse effects and added costs." | 2.72 | Serum Albumin Levels: Who Needs Them? ( Erstad, BL, 2021) |
| "Phenytoin has a narrow therapeutic index and the potential of under-treatment or toxicity." | 1.56 | A Novel Correction Equation Avoids High-Magnitude Errors in Interpreting Therapeutic Drug Monitoring of Phenytoin Among Critically Ill Patients. ( Barra, ME; Chung, DY; Phillips, KM; Rosenthal, ES, 2020) |
| "Phenytoin is a common medication for seizure treatment and prophylaxis in the intensive care unit (ICU)." | 1.43 | Correlation of Free and Total Phenytoin Serum Concentrations in Critically Ill Patients. ( Barletta, JF; Bikin, DS; Buckley, MS; Reeves, BA, 2016) |
| "Phenytoin has a narrow therapeutic window, and when managing cases of toxicity, clinicians are very wary of this fact." | 1.40 | Free phenytoin toxicity. ( Gambhir, H; Imam, SH; John, D; Kaul, V; Kloss, B; Landry, K, 2014) |
| " Although clinicians are aware of the interaction with two widely used antituberculosis agents, rifampin and isoniazid, few reports have described the implications for managing phenytoin dosing in this situation." | 1.39 | Phenytoin-rifampin drug interaction in a hypoalbuminemic, renal failure patient: a complex clinical case. ( Hurdle, AC; Twilla, JD; Van Berkel, MA, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Barra, ME | 1 |
| Phillips, KM | 1 |
| Chung, DY | 1 |
| Rosenthal, ES | 1 |
| Erstad, BL | 1 |
| Madan, A | 1 |
| Donovan, PJ | 1 |
| Risetto, T | 1 |
| Trenerry, H | 1 |
| Lander, CM | 1 |
| Khan, AM | 1 |
| Marvanova, M | 1 |
| Montgomery, MC | 1 |
| Chou, JW | 1 |
| McPharlin, TO | 1 |
| Baird, GS | 1 |
| Anderson, GD | 1 |
| Van Berkel, MA | 1 |
| Hurdle, AC | 1 |
| Twilla, JD | 1 |
| Imam, SH | 1 |
| Landry, K | 1 |
| Kaul, V | 1 |
| Gambhir, H | 1 |
| John, D | 1 |
| Kloss, B | 1 |
| Mohammadi, F | 1 |
| MacLasco, A | 1 |
| Paloucek, FP | 1 |
| Buckley, MS | 1 |
| Reeves, BA | 1 |
| Barletta, JF | 1 |
| Bikin, DS | 1 |
| Wolf, GK | 1 |
| McClain, CD | 1 |
| Zurakowski, D | 1 |
| Dodson, B | 1 |
| McManus, ML | 1 |
| Kemper, EM | 1 |
| van Kan, HJ | 1 |
| Speelman, P | 1 |
| de Gans, K | 1 |
| Beijnen, JH | 1 |
| Schellens, JH | 1 |
1 review available for phenytoin and Hypoalbuminemia
| Article | Year |
|---|---|
Serum Albumin Levels: Who Needs Them?
Topics: Adult; Critical Illness; Humans; Hypoalbuminemia; Intensive Care Units; Phenytoin; Serum Albumin | 2021 |
10 other studies available for phenytoin and Hypoalbuminemia
| Article | Year |
|---|---|
A Novel Correction Equation Avoids High-Magnitude Errors in Interpreting Therapeutic Drug Monitoring of Phenytoin Among Critically Ill Patients.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Critical Care; Critical Illness; Drug Monitoring; F | 2020 |
Monitoring for valproate and phenytoin toxicity in hypoalbuminaemia: A retrospective cohort study.
Topics: Cohort Studies; Humans; Hypoalbuminemia; Phenytoin; Retrospective Studies; Valproic Acid | 2021 |
Prediction Accuracy of Winter-Tozer Equations to Estimate Free Phenytoin Concentrations in Non-Critically Ill Hospitalized Patients.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Black or African American; Female; Hospitalization; | 2017 |
Predicting Unbound Phenytoin Concentrations: Effects of Albumin Concentration and Kidney Dysfunction.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Creatinine; Female; Glomerular Filtrati | 2019 |
Phenytoin-rifampin drug interaction in a hypoalbuminemic, renal failure patient: a complex clinical case.
Topics: Acute Kidney Injury; Anticonvulsants; Antitubercular Agents; Dose-Response Relationship, Drug; Drug | 2013 |
Free phenytoin toxicity.
Topics: Aged; Anticonvulsants; Chemical and Drug Induced Liver Injury; Gait Disorders, Neurologic; Humans; H | 2014 |
Inappropriate utilization of the Sheiner-Tozer equation to determine phenytoin toxicity.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Gait Disorders, Neurologic; Humans; Hypoalb | 2015 |
Correlation of Free and Total Phenytoin Serum Concentrations in Critically Ill Patients.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Critical Illness; Decision Making; Female; Humans; | 2016 |
Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Anticonvulsants; Blood Chemical Analysis; Cefazolin; Child | 2006 |
[Severe phenytoin intoxication in patients with hypoalbuminaemia].
Topics: Adult; Anticonvulsants; Blood Proteins; Drug Monitoring; Fatal Outcome; Female; Humans; Hypoalbumine | 2007 |