Page last updated: 2024-10-21

phenytoin and Hyperammonemia

phenytoin has been researched along with Hyperammonemia in 7 studies

Hyperammonemia: Elevated level of AMMONIA in the blood. It is a sign of defective CATABOLISM of AMINO ACIDS or ammonia to UREA.

Research Excerpts

ExcerptRelevanceReference
"Valproic acid (VPA), which is widely used to treat epilepsy, migraine, and bipolar disorder, can causes severe hyperammonemia."7.81Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy. ( Hirai, K; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y, 2015)
"Valproic acid, which is widely used to treat various types of epilepsy, may cause severe hyperammonemia."7.804217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. ( Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Miyakawa, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R, 2014)
"We present a case of a 29-year-old female with a history of epilepsy who was admitted for convulsive status epilepticus (CSE), which was controlled by intravenous VPA, as well as oral VPA and phenytoin."4.31Valproate-related hyperammonemic encephalopathy with generalized suppression EEG: a case report. ( Liu, X; Peng, X, 2023)
"Valproic acid (VPA), which is widely used to treat epilepsy, migraine, and bipolar disorder, can causes severe hyperammonemia."3.81Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy. ( Hirai, K; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y, 2015)
"Valproic acid, which is widely used to treat various types of epilepsy, may cause severe hyperammonemia."3.804217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. ( Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Miyakawa, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R, 2014)
"Hyperammonemia was defined as a plasma ammonia level exceeding 100 μg/dl with reference to the standard range and previous reports."1.39Risk factors for hyperammonemia in pediatric patients with epilepsy. ( Imai, K; Inoue, K; Inoue, Y; Itoh, K; Kagawa, Y; Mishima, N; Takahashi, Y; Yamamoto, Y; Yazawa, R, 2013)
"Transient hyperammonemia was noted."1.35Postictal transient hyperammonemia. ( Liu, KT; Su, CS, 2008)
"To describe the dose-concentration relationship of a continuous intravenous infusion of valproic acid (VPA) in pediatric patients when a dosing protocol is used."1.34Clinical utility of a continuous intravenous infusion of valproic acid in pediatric patients. ( Baumann, RJ; Cook, AM; Farzam, F; Kuhn, RJ; Lewis, DA; Taylor, LM, 2007)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's3 (42.86)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Liu, X1
Peng, X1
Yamamoto, Y3
Takahashi, Y3
Imai, K3
Mishima, N1
Yazawa, R2
Inoue, K3
Itoh, K3
Kagawa, Y1
Inoue, Y3
Suzuki, E2
Takahashi, T2
Miyakawa, K1
Tsuji, D2
Hayashi, H1
Hirai, K1
Taylor, LM1
Farzam, F1
Cook, AM1
Lewis, DA1
Baumann, RJ1
Kuhn, RJ1
Velioğlu, SK1
Gazioğlu, S1
Liu, KT1
Su, CS1

Other Studies

7 other studies available for phenytoin and Hyperammonemia

ArticleYear
Valproate-related hyperammonemic encephalopathy with generalized suppression EEG: a case report.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023, Volume: 44, Issue:10

    Topics: Adult; Anticonvulsants; Brain Diseases; Electroencephalography; Epilepsy; Female; Humans; Hyperammon

2023
Risk factors for hyperammonemia in pediatric patients with epilepsy.
    Epilepsia, 2013, Volume: 54, Issue:6

    Topics: Acetazolamide; Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Dose-Response Rela

2013
4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy.
    Epilepsy research, 2014, Volume: 108, Issue:6

    Topics: Alleles; Amino-Acid N-Acetyltransferase; Ammonia; Anticonvulsants; Asian People; Biomarkers, Pharmac

2014
Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy.
    Seizure, 2015, Volume: 33

    Topics: Adolescent; Ammonia; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Genotype; Glutamate

2015
Clinical utility of a continuous intravenous infusion of valproic acid in pediatric patients.
    Pharmacotherapy, 2007, Volume: 27, Issue:4

    Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combinatio

2007
Non-convulsive status epilepticus secondary to valproic acid-induced hyperammonemic encephalopathy.
    Acta neurologica Scandinavica, 2007, Volume: 116, Issue:2

    Topics: Adult; Ammonia; Anticonvulsants; Brain; Electroencephalography; Hepatic Encephalopathy; Humans; Hype

2007
Postictal transient hyperammonemia.
    The American journal of emergency medicine, 2008, Volume: 26, Issue:3

    Topics: Adult; Anticonvulsants; Epilepsy, Tonic-Clonic; Humans; Hyperammonemia; Liver Function Tests; Male;

2008