phenytoin has been researched along with Huntington Disease in 5 studies
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diphenylhydantoin (DPH) diminished the therapeutic effects of levodopa both in patients with parkinsonism and in patients with chronic manganese poisoning, as well as the levodopa-dependent dyskinesia for which the former were selected." | 3.65 | Diphenylhydantoin. Blocking of levodopa effects. ( Cotzias, GC; Mena, I; Mendez, JS; Papavasiliou, PS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mendez, JS | 1 |
| Cotzias, GC | 1 |
| Mena, I | 1 |
| Papavasiliou, PS | 1 |
| Lamprecht, F | 1 |
| Kato, M | 1 |
| Araki, S | 1 |
| Critchley, EM | 1 |
| Clark, DB | 1 |
| Wikler, A | 1 |
| Jung, SS | 1 |
| Chen, KM | 1 |
| Brody, JA | 1 |
1 review available for phenytoin and Huntington Disease
| Article | Year |
|---|---|
Epilepsy and schizophrenia: a neurochemical bridge.
Topics: Amphetamine; Anticonvulsants; Brain; Butyrophenones; Disulfiram; Dopamine; Dopamine beta-Hydroxylase | 1977 |
4 other studies available for phenytoin and Huntington Disease
| Article | Year |
|---|---|
Diphenylhydantoin. Blocking of levodopa effects.
Topics: Adult; Aged; Dopamine; Female; Humans; Huntington Disease; Levodopa; Male; Manganese Poisoning; Midd | 1975 |
Paroxysmal kinesignenic choreoathetosis. Report of a case relieved by carbamazepine.
Topics: Adolescent; Athetosis; Carbamazepine; Diazepam; Dibenzazepines; Diphenhydramine; Female; Humans; Hun | 1969 |
An adult form of acanthocytosis.
Topics: Abetalipoproteinemia; Adult; Ataxia; Diazepam; Female; Haloperidol; Humans; Huntington Disease; Hydr | 1967 |
Paroxysmal choreoathetosis. Report of Chinese cases.
Topics: Adult; Age Factors; Athetosis; China; Electroencephalography; Epilepsy; Female; Humans; Huntington D | 1973 |