phenytoin has been researched along with Hepatocellular Carcinoma in 7 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The prediction of drug-drug interactions mediated by the induction or inhibition of cytochrome P450 enzymes is of great relevance in the development of new drugs." | 1.40 | HepaRG cell line as an in vitro model for screening drug-drug interactions mediated by metabolic induction: amiodarone used as a model substance. ( Alves, G; Falcão, A; Ferreira, A; Rodrigues, M; Silvestre, S, 2014) |
| " Transfected cells were dosed with several known inducers of CYP3A4 and the levels of SPAP were measured." | 1.30 | A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro. ( Gibson, GG; Goldfarb, PS; Gray, TJ; Ogg, MS; Tarbit, M; Williams, JM, 1999) |
| "(3) A human hepatoma cell line (Hep G2) was studied to obtain information on the inducibility of human UDP-GT activities by 3-methylcholanthrene-type inducers." | 1.27 | Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers. ( Bock, KW; Bock-Hennig, BS, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferreira, A | 1 |
| Rodrigues, M | 1 |
| Silvestre, S | 1 |
| Falcão, A | 1 |
| Alves, G | 1 |
| Hung, DZ | 1 |
| Lin, CL | 1 |
| Li, YW | 1 |
| Lin, YN | 1 |
| Lee, YR | 1 |
| Wang, CN | 1 |
| Chen, JJ | 1 |
| Lim, YP | 1 |
| Trubetskoy, O | 1 |
| Marks, B | 1 |
| Zielinski, T | 1 |
| Yueh, MF | 1 |
| Raucy, J | 1 |
| Chhabra, RS | 1 |
| Bucher, JR | 1 |
| Haseman, JK | 1 |
| Elwell, MR | 1 |
| Kurtz, PJ | 1 |
| Carlton, BD | 1 |
| Ogg, MS | 1 |
| Williams, JM | 1 |
| Tarbit, M | 1 |
| Goldfarb, PS | 1 |
| Gray, TJ | 1 |
| Gibson, GG | 1 |
| Kirkegaard, P | 1 |
| Bock, KW | 1 |
| Bock-Hennig, BS | 1 |
7 other studies available for phenytoin and Hepatocellular Carcinoma
| Article | Year |
|---|---|
HepaRG cell line as an in vitro model for screening drug-drug interactions mediated by metabolic induction: amiodarone used as a model substance.
Topics: Amiodarone; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 Enzyme System; Drug Intera | 2014 |
Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population-based case-control study.
Topics: Adult; Aged; Anticonvulsants; Carcinoma, Hepatocellular; Case-Control Studies; Epilepsy; Humans; Liv | 2016 |
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Clotrimazole; Cytochrome P-450 CYP1A2; Cytoch | 2005 |
Comparative carcinogenicity of 5,5-diphenylhydantoin with or without perinatal exposure in rats and mice.
Topics: Adenoma, Liver Cell; Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Female; Fetal Dea | 1993 |
A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.
Topics: Alkaline Phosphatase; beta-Naphthoflavone; Caffeine; Carbamazepine; Carcinoma, Hepatocellular; Clofi | 1999 |
[Hepatocellular adenoma].
Topics: Abdomen; Adult; Carcinoma, Hepatocellular; Epilepsy; Hemorrhage; Humans; Liver Neoplasms; Male; Phen | 1976 |
Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers.
Topics: Acetaminophen; Adolescent; Adult; Benzopyrenes; Bilirubin; Carcinoma, Hepatocellular; Enzyme Inducti | 1987 |