Compounds > phenytoin
Page last updated: 2024-10-21

phenytoin and Harelip

phenytoin has been researched along with Harelip in 43 studies

Research Excerpts

ExcerptRelevanceReference
"High incidences of cleft lip and palate (CLP) produced by maternal intraperitoneal administration of 75 mg/kg phenytoin on gestational day 10 to A/J mice are associated with a severe size reduction in the lateral nasal process."7.66Phenytoin (dilantin)-induced cleft lip and palate in A/J mice: a scanning and transmission electron microscopic study. ( Ambrose, LJ; Dorgan, D; Johnston, MC; Sulik, KK, 1979)
"Malignant mesenchymoma developed in an 18-year-old patient with phenytoin-associated cleft lip and palate."7.65Malignant mesenchymoma and birth defects. Prenatal exposure to phenytoin. ( Blattner, WA; Fraumeni, JF; Henson, DE; Young, RC, 1977)
"An increased risk for isolated CL/P was found in cases born to mothers treated with amoxicillin, phenytoin, oxprenolol, and thiethylperazine during the second and third month of pregnancy, i."3.74Drug treatment during pregnancy and isolated orofacial clefts in hungary. ( Czeizel, AE; Métneki, J; Puhó, EH; Szunyogh, M, 2007)
" We compare results obtained using phenytoin (which induces cleft lip) and 6-aminonicotinamide (which induces cleft palate)."3.69Genome scan for teratogen-induced clefting susceptibility loci in the mouse: evidence of both allelic and locus heterogeneity distinguishing cleft lip and cleft palate. ( Diehl, SR; Erickson, RP, 1997)
" 6-Aminonicotinamide-induced cleft palate and phenytoin-induced cleft lip with or without cleft palate are also influenced by this genetic region but not as strongly."3.68Major effects on teratogen-induced facial clefting in mice determined by a single genetic region. ( Erickson, RP; Karolyi, J; Killewald, L; Liu, S, 1990)
"Inbred and congenic strains of mice have been studied for susceptibility to phenytoin-induced cleft lip with or without cleft palate (CLP) and isolated cleft palate (CP)."3.66Phenytoin teratogenicity in the primary and secondary mouse embryonic palate is influenced by the H-2 histocompatibility locus. ( Baker, MK; Fishman, CL; Goldman, AS, 1983)
"High incidences of cleft lip and palate (CLP) produced by maternal intraperitoneal administration of 75 mg/kg phenytoin on gestational day 10 to A/J mice are associated with a severe size reduction in the lateral nasal process."3.66Phenytoin (dilantin)-induced cleft lip and palate in A/J mice: a scanning and transmission electron microscopic study. ( Ambrose, LJ; Dorgan, D; Johnston, MC; Sulik, KK, 1979)
"Malignant mesenchymoma developed in an 18-year-old patient with phenytoin-associated cleft lip and palate."3.65Malignant mesenchymoma and birth defects. Prenatal exposure to phenytoin. ( Blattner, WA; Fraumeni, JF; Henson, DE; Young, RC, 1977)
" In the Hungarian Congenital Malformation Register use of the anticonvulsants diazepam and phenobarbiturates during pregnancy was determined in infants delivered with cleft lip with or without cleft palate, posterior cleft palate and, as a control, anencephaly and spina bifida."3.65A teratological evaluation of anticonvulsant drugs. ( Czeizel, E; Lakos, P, 1977)
"We have chosen to study the role of genetic susceptibility to teratogen-induced orofacial clefting, using 2 drugs (dilantin and corticosteroid) and 1 nondrug teratogen (6-aminonicotinamide)."2.46Genes, environment, and orofacial clefting: N-acetyltransferase and folic acid. ( Erickson, RP, 2010)
"Phenytoin (PHT) is a risk factor of cleft palate formation; however, the molecular mechanisms by which phenytoin exerts its teratogenic effects resulting in cleft palate remain unknown."1.36Effects of phenytoin on Satb2 and Hoxa2 gene expressions in mouse embryonic craniofacial tissue. ( Mao, XY; Tang, SJ, 2010)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-199029 (67.44)18.7374
1990's5 (11.63)18.2507
2000's4 (9.30)29.6817
2010's2 (4.65)24.3611
2020's3 (6.98)2.80

Authors

AuthorsStudies
Tsukiboshi, Y1
Ogata, A1
Noguchi, A1
Mikami, Y1
Yokota, S1
Ogata, K1
Yoshioka, H2
Nakatomi, M1
Ludwig, KU1
Knapp, M1
Kist, R1
Lisgo, S1
Ohshima, H1
Mangold, E1
Peters, H1
Ramakrishnan, SS1
Suzuki, A1
Iwata, J1
Mao, XY1
Tang, SJ1
Erickson, RP5
Abela, D2
Howe, AM2
Oakes, DA1
Webster, WS2
Oakes, DJ1
Puhó, EH1
Szunyogh, M1
Métneki, J1
Czeizel, AE1
Cao, W1
Acuña, DK1
Strnatka, DW1
Hunter, RJ1
Chau, BT1
Wakefield, LV1
Sim, E1
McQueen, CA1
Hansen, DK2
Hodes, ME1
Goldman, AS1
Fishman, CL1
Baker, MK1
Maeda, K1
Shimizu, H1
Satomi, N1
Endo, K1
Hashiba, M1
Shimoji, K1
Nakane, Y1
Millicovsky, G1
Johnston, MC2
Buehler, BA1
Rao, V1
Finnell, RH1
Marks, P1
Mills, B1
West, L1
Diehl, SR1
Czeizel, A1
Friis, ML1
Sulik, KK1
Ambrose, LJ1
Dorgan, D1
Blattner, WA1
Henson, DE1
Young, RC1
Fraumeni, JF1
Lakos, P1
Czeizel, E1
Anderson, RC1
Husquinet, H1
Biale, Y1
Lewenthal, H1
Aderet, NB1
Annegers, JF2
Elveback, LR2
Hauser, WA2
Kurland, LT2
Durner, M1
Greenberg, DA1
Delgado-Escueta, AV1
Karolyi, J1
Liu, S2
Killewald, L1
Karolyi, IJ1
Billings, RE1
Niebyl, JR1
Blake, DA1
Rocco, LE1
Baumgardner, R1
Mellits, ED1
Lowe, CR1
Fraser, FC1
Hill, RM1
Meyer, JG1
Mirkin, BL1
Elshove, J2
Dunstone, M1
Harbison, RD1
Becker, BA2
van Eck, JH1
Gibson, JE1
Massey, KM1

Reviews

4 reviews available for phenytoin and Harelip

ArticleYear
Genes, environment, and orofacial clefting: N-acetyltransferase and folic acid.
    The Journal of craniofacial surgery, 2010, Volume: 21, Issue:5

    Topics: 6-Aminonicotinamide; Animals; Arylamine N-Acetyltransferase; Cleft Lip; Cleft Palate; Disease Models

2010
The relationship between cleft lip, maxillary hypoplasia, hypoxia and phenytoin.
    Current pharmaceutical design, 2006, Volume: 12, Issue:12

    Topics: Animals; Anticonvulsants; Cleft Lip; Female; Fetal Hypoxia; Humans; Maxilla; Organogenesis; Phenytoi

2006
Biochemical and molecular teratology of fetal hydantoin syndrome.
    Neurologic clinics, 1994, Volume: 12, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Disease Models, Animal; Epilepsy; Face; Female; Fet

1994
Is there a genetic relationship between epilepsy and birth defects?
    Neurology, 1992, Volume: 42, Issue:4 Suppl 5

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Congenital Abnormalities; Dis

1992

Other Studies

39 other studies available for phenytoin and Harelip

ArticleYear
Sasa veitchii extracts protect phenytoin-induced cell proliferation inhibition in human lip mesenchymal cells through modulation of miR-27b-5p.
    Biomedical research (Tokyo, Japan), 2023, Volume: 44, Issue:2

    Topics: Cell Proliferation; Child; Cleft Lip; Cleft Palate; Female; Humans; MicroRNAs; Phenytoin; Pregnancy;

2023
    Development (Cambridge, England), 2020, 06-24, Volume: 147, Issue:21

    Topics: Animals; Bone Morphogenetic Protein 4; Cleft Lip; Female; Gene Expression Regulation, Developmental;

2020
Phenytoin Inhibits Cell Proliferation through microRNA-196a-5p in Mouse Lip Mesenchymal Cells.
    International journal of molecular sciences, 2021, Feb-09, Volume: 22, Issue:4

    Topics: Animals; Cell Line; Cell Proliferation; Cleft Lip; Disease Models, Animal; Embryo, Mammalian; Female

2021
Effects of phenytoin on Satb2 and Hoxa2 gene expressions in mouse embryonic craniofacial tissue.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 2010, Volume: 88, Issue:4

    Topics: Animals; Anticonvulsants; Cleft Lip; Cleft Palate; Embryo, Mammalian; Face; Female; Fetus; Gene Expr

2010
Maternal antioxidant supplementation does not reduce the incidence of phenytoin-induced cleft lip and related malformations in rats.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2005, Volume: 74, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Antioxidants; Ascorbic Acid; Body Weight; Cle

2005
Drug treatment during pregnancy and isolated orofacial clefts in hungary.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2007, Volume: 44, Issue:2

    Topics: Abnormalities, Drug-Induced; Adrenergic beta-Antagonists; Amoxicillin; Anti-Bacterial Agents; Antico

2007
Confirmation of the role of N-acetyltransferase 2 in teratogen-induced cleft palate using transgenics and knockouts.
    Molecular reproduction and development, 2008, Volume: 75, Issue:6

    Topics: 6-Aminonicotinamide; Animals; Arylamine N-Acetyltransferase; Base Sequence; Cleft Lip; Cleft Palate;

2008
Comparative teratogenicity of phenytoin among several inbred strains of mice.
    Teratology, 1983, Volume: 28, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Dose-Response Relationship, Drug; Fem

1983
Phenytoin teratogenicity in the primary and secondary mouse embryonic palate is influenced by the H-2 histocompatibility locus.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1983, Volume: 173, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Disease Susceptibility; Female; H-2 A

1983
[Anesthesia in an infant with fetal hydantoin syndrome].
    Masui. The Japanese journal of anesthesiology, 1982, Volume: 31, Issue:11

    Topics: Abnormalities, Drug-Induced; Anesthesia, Endotracheal; Cleft Lip; Cleft Palate; Humans; Infant; Male

1982
The teratological problem of antiepileptic drugs.
    Folia psychiatrica et neurologica japonica, 1980, Volume: 34, Issue:3

    Topics: Abnormalities, Drug-Induced; Adult; Animals; Anticonvulsants; Chromosome Aberrations; Cleft Lip; Cle

1980
Maternal hyperoxia greatly reduces the incidence of phenytoin-induced cleft lip and palate in A/J mice.
    Science (New York, N.Y.), 1981, May-08, Volume: 212, Issue:4495

    Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Female; Mice; Mice, Inbred A; Oxygen;

1981
Basilar invagination and mid-line skeletal abnormalities due to in utero exposure to phenytoin.
    British journal of neurosurgery, 1994, Volume: 8, Issue:3

    Topics: Adult; Arnold-Chiari Malformation; Bone Transplantation; Cleft Lip; Cleft Palate; Diseases in Twins;

1994
Genome scan for teratogen-induced clefting susceptibility loci in the mouse: evidence of both allelic and locus heterogeneity distinguishing cleft lip and cleft palate.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, May-13, Volume: 94, Issue:10

    Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Alleles; Animals; Chromosome Mapping; Cleft Lip; C

1997
Letter: Diazepam, phenytoin, and aetiology of cleft lip and/or cleft palate.
    Lancet (London, England), 1976, Apr-10, Volume: 1, Issue:7963

    Topics: Anencephaly; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Infant, Newborn; Phenytoin; Pregnanc

1976
Epilepsy among parents of children with facial clefts.
    Epilepsia, 1979, Volume: 20, Issue:1

    Topics: Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Male; Parents; Phenobarbital; Ph

1979
Phenytoin (dilantin)-induced cleft lip and palate in A/J mice: a scanning and transmission electron microscopic study.
    The Anatomical record, 1979, Volume: 195, Issue:2

    Topics: Animals; Cleft Lip; Cleft Palate; Female; Lip; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains;

1979
Malignant mesenchymoma and birth defects. Prenatal exposure to phenytoin.
    JAMA, 1977, Jul-25, Volume: 238, Issue:4

    Topics: Adolescent; Adult; Cleft Lip; Cleft Palate; Epilepsy; Female; Follow-Up Studies; Humans; Male; Mater

1977
A teratological evaluation of anticonvulsant drugs.
    Acta paediatrica Academiae Scientiarum Hungaricae, 1977, Volume: 18, Issue:2

    Topics: Abnormalities, Drug-Induced; Anencephaly; Anticonvulsants; Cleft Lip; Cleft Palate; Diazepam; Epilep

1977
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
    The Journal of pediatrics, 1976, Volume: 89, Issue:2

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio

1976
[Are anticonvulsant agents teratogenic].
    Revue medicale de Liege, 1975, Aug-01, Volume: 30, Issue:15

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Humans; Infant, Newborn; Male

1975
Congenital malformations due to anticonvulsive drugs.
    Obstetrics and gynecology, 1975, Volume: 45, Issue:4

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord

1975
Epilepsy anticonvulsants and malformations.
    Birth defects original article series, 1975, Volume: 11, Issue:5

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec

1975
Major effects on teratogen-induced facial clefting in mice determined by a single genetic region.
    Genetics, 1990, Volume: 126, Issue:1

    Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Animals; Chromosomes; Cleft Lip; Cleft Palate; Gen

1990
Susceptibility to phenytoin-induced cleft lip with or without cleft palate: many genes are involved.
    Genetical research, 1987, Volume: 49, Issue:1

    Topics: Animals; Cleft Lip; Cleft Palate; Disease Susceptibility; Mice; Mice, Inbred Strains; Phenytoin; Rec

1987
Effect of route of administration on phenytoin teratogenicity in A/J mice.
    Journal of craniofacial genetics and developmental biology, 1986, Volume: 6, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Diet; Female; Fetal Resorption; Injec

1986
Lack of maternal metabolic, endocrine, and environmental influences in the etiology of cleft lip with or without cleft palate.
    The Cleft palate journal, 1985, Volume: 22, Issue:1

    Topics: Adult; Cleft Lip; Cleft Palate; Drug Interactions; Endocrine Glands; Erythrocytes; Female; Folic Aci

1985
Congenital malformations among infants born to epileptic women.
    Lancet (London, England), 1973, Jan-06, Volume: 1, Issue:7793

    Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Congenital Abnormalities; England; Epilepsy; F

1973
Do anticonvulsants have a teratogenic effect?
    Archives of neurology, 1974, Volume: 31, Issue:6

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Cleft Palate; Congenital

1974
Updating the genetics of cleft lip and palate.
    Birth defects original article series, 1974, Volume: 10, Issue:8

    Topics: Cleft Lip; Cleft Palate; Environmental Exposure; Face; Female; Humans; Male; Maternal Age; Nervous S

1974
Editorial: Teratogenesis and antiepileptic drugs.
    The New England journal of medicine, 1973, Nov-15, Volume: 289, Issue:20

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Congenital Abnormalities; Epi

1973
The teratological effects of anticonvulsants and the effects on pregnancy and birth.
    European neurology, 1973, Volume: 10, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cleft Lip; Cleft Palate; Cyclohe

1973
Placental transfer and neonatal elimination of diphenylhydantoin.
    American journal of obstetrics and gynecology, 1971, Mar-15, Volume: 109, Issue:6

    Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Infant, Newborn; Lon

1971
[Teratogenic effect of phenytoin].
    Nederlands tijdschrift voor geneeskunde, 1972, Jan-15, Volume: 116, Issue:3

    Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Infant, Newborn; Phe

1972
Dilantin and hare-lip.
    The Medical journal of Australia, 1972, Jul-01, Volume: 2, Issue:1

    Topics: Abnormalities, Drug-Induced; Cleft Lip; Female; Humans; Infant, Newborn; Phenytoin; Pregnancy

1972
Relation of dosage and time of administration of diphenylhydantoin to its teratogenic effect in mice.
    Teratology, 1969, Volume: 2, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Lip; Cleft Palate; Embryonic and Fetal Deve

1969
[Congenital abnormalities, cleft lip and cleft palate in particular, in children of epileptic mothers].
    Nederlands tijdschrift voor geneeskunde, 1971, Aug-14, Volume: 115, Issue:33

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Cleft Lip; Cleft Palate; Epilepsy; Fema

1971
Teratogenic effects of diphenylhydantoin in Swiss-Webster and A-J mice.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1968, Volume: 128, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Female; Femur; Fetus; Fibula; Humerus

1968
Teratogenic effects of diphenylhydantoin sodium.
    Journal of oral therapeutics and pharmacology, 1966, Volume: 2, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Female; Mice; Phenytoin; Pregnancy; P

1966