Page last updated: 2024-10-21

phenytoin and HIV

phenytoin has been researched along with HIV in 5 studies

HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.

Research Excerpts

ExcerptRelevanceReference
"To confirm whether 7 days of phenytoin, an enzyme inducer, would decrease the elimination half-life of single-dose nevirapine and to investigate its effect on the development of nevirapine resistance in pregnant, HIV-infected women."9.17Effect of 7 days of phenytoin on the pharmacokinetics of and the development of resistance to single-dose nevirapine for perinatal HIV prevention: a randomized pilot trial. ( Aitken, S; Burger, DM; Chunda, C; Fillekes, Q; Gibb, DM; Kankasa, C; Kisanga, ER; Muro, EP; Thomason, MJ; Walker, AS, 2013)
"To confirm whether 7 days of phenytoin, an enzyme inducer, would decrease the elimination half-life of single-dose nevirapine and to investigate its effect on the development of nevirapine resistance in pregnant, HIV-infected women."5.17Effect of 7 days of phenytoin on the pharmacokinetics of and the development of resistance to single-dose nevirapine for perinatal HIV prevention: a randomized pilot trial. ( Aitken, S; Burger, DM; Chunda, C; Fillekes, Q; Gibb, DM; Kankasa, C; Kisanga, ER; Muro, EP; Thomason, MJ; Walker, AS, 2013)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fillekes, Q1
Muro, EP1
Chunda, C1
Aitken, S1
Kisanga, ER1
Kankasa, C1
Thomason, MJ1
Gibb, DM1
Walker, AS1
Burger, DM1
Mosley, AK1
Brouwer, KL1
Dasgupta, A1
Wells, A1
Chow, L1
Zimmer, JP1
Lehr, HA1
Kornhuber, ME1
Breitig, D1
Montagnier, L1
Gietzen, K1
Ghosh, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Phenytoin on the Pharmacokinetics of Nevirapine and the Development of Nevirapine Resistance After a Single Dose Nevirapine (VIramune®), Which is Part of ARV Prophylaxis for PMTCT in Moshi, TAnzania, and in Lusaka, Zambia (VITA2 Trial)[NCT01187719]Phase 266 participants (Actual)Interventional2010-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for phenytoin and HIV

ArticleYear
Effect of 7 days of phenytoin on the pharmacokinetics of and the development of resistance to single-dose nevirapine for perinatal HIV prevention: a randomized pilot trial.
    The Journal of antimicrobial chemotherapy, 2013, Volume: 68, Issue:11

    Topics: Adult; Anti-HIV Agents; Anticonvulsants; Drug Interactions; Drug Resistance, Viral; Female; Half-Lif

2013

Other Studies

4 other studies available for phenytoin and HIV

ArticleYear
Heat treatment of human serum to inactivate HIV does not alter protein binding of selected drugs.
    Therapeutic drug monitoring, 1997, Volume: 19, Issue:4

    Topics: Anti-Arrhythmia Agents; Anticonvulsants; Blood Proteins; Diazepam; Digitoxin; HIV; Hot Temperature;

1997
Effect of heating human sera at a temperature necessary to deactivate human immunodeficiency virus on measurement of free phenytoin, free valproic acid, and free carbamazepine concentrations.
    Therapeutic drug monitoring, 1999, Volume: 21, Issue:4

    Topics: Anticonvulsants; Blood; Carbamazepine; Hemofiltration; HIV; Hot Temperature; Humans; Phenytoin; Valp

1999
Diphenylhydantoin (DPH) blocks HIV-receptor on T-lymphocyte surface.
    Blut, 1986, Volume: 53, Issue:6

    Topics: Cells, Cultured; HIV; Humans; Iodine Radioisotopes; Phenytoin; Receptors, Virus; T-Lymphocytes

1986
Diphenylhydantoin (DPH) blocks HIV receptor on T-lymphocyte surface. A clarification.
    Blut, 1987, Volume: 55, Issue:6

    Topics: HIV; Humans; Phenytoin; Receptors, HIV; Receptors, Virus; T-Lymphocytes

1987