phenytoin and HIV
phenytoin has been researched along with HIV in 5 studies
HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To confirm whether 7 days of phenytoin, an enzyme inducer, would decrease the elimination half-life of single-dose nevirapine and to investigate its effect on the development of nevirapine resistance in pregnant, HIV-infected women." | 9.17 | Effect of 7 days of phenytoin on the pharmacokinetics of and the development of resistance to single-dose nevirapine for perinatal HIV prevention: a randomized pilot trial. ( Aitken, S; Burger, DM; Chunda, C; Fillekes, Q; Gibb, DM; Kankasa, C; Kisanga, ER; Muro, EP; Thomason, MJ; Walker, AS, 2013) |
| "To confirm whether 7 days of phenytoin, an enzyme inducer, would decrease the elimination half-life of single-dose nevirapine and to investigate its effect on the development of nevirapine resistance in pregnant, HIV-infected women." | 5.17 | Effect of 7 days of phenytoin on the pharmacokinetics of and the development of resistance to single-dose nevirapine for perinatal HIV prevention: a randomized pilot trial. ( Aitken, S; Burger, DM; Chunda, C; Fillekes, Q; Gibb, DM; Kankasa, C; Kisanga, ER; Muro, EP; Thomason, MJ; Walker, AS, 2013) |
Research
Studies (5)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Fillekes, Q | 1 |
| Muro, EP | 1 |
| Chunda, C | 1 |
| Aitken, S | 1 |
| Kisanga, ER | 1 |
| Kankasa, C | 1 |
| Thomason, MJ | 1 |
| Gibb, DM | 1 |
| Walker, AS | 1 |
| Burger, DM | 1 |
| Mosley, AK | 1 |
| Brouwer, KL | 1 |
| Dasgupta, A | 1 |
| Wells, A | 1 |
| Chow, L | 1 |
| Zimmer, JP | 1 |
| Lehr, HA | 1 |
| Kornhuber, ME | 1 |
| Breitig, D | 1 |
| Montagnier, L | 1 |
| Gietzen, K | 1 |
| Ghosh, K | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Phenytoin on the Pharmacokinetics of Nevirapine and the Development of Nevirapine Resistance After a Single Dose Nevirapine (VIramune®), Which is Part of ARV Prophylaxis for PMTCT in Moshi, TAnzania, and in Lusaka, Zambia (VITA2 Trial)[NCT01187719] | Phase 2 | 66 participants (Actual) | Interventional | 2010-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trials
1 trial available for phenytoin and HIV
| Article | Year |
|---|---|
Effect of 7 days of phenytoin on the pharmacokinetics of and the development of resistance to single-dose nevirapine for perinatal HIV prevention: a randomized pilot trial.
Topics: Adult; Anti-HIV Agents; Anticonvulsants; Drug Interactions; Drug Resistance, Viral; Female; Half-Lif | 2013 |
Other Studies
4 other studies available for phenytoin and HIV
| Article | Year |
|---|---|
Heat treatment of human serum to inactivate HIV does not alter protein binding of selected drugs.
Topics: Anti-Arrhythmia Agents; Anticonvulsants; Blood Proteins; Diazepam; Digitoxin; HIV; Hot Temperature; | 1997 |
Effect of heating human sera at a temperature necessary to deactivate human immunodeficiency virus on measurement of free phenytoin, free valproic acid, and free carbamazepine concentrations.
Topics: Anticonvulsants; Blood; Carbamazepine; Hemofiltration; HIV; Hot Temperature; Humans; Phenytoin; Valp | 1999 |
Diphenylhydantoin (DPH) blocks HIV-receptor on T-lymphocyte surface.
Topics: Cells, Cultured; HIV; Humans; Iodine Radioisotopes; Phenytoin; Receptors, Virus; T-Lymphocytes | 1986 |
Diphenylhydantoin (DPH) blocks HIV receptor on T-lymphocyte surface. A clarification.
Topics: HIV; Humans; Phenytoin; Receptors, HIV; Receptors, Virus; T-Lymphocytes | 1987 |