phenytoin has been researched along with HIV Infections in 14 studies
HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To confirm whether 7 days of phenytoin, an enzyme inducer, would decrease the elimination half-life of single-dose nevirapine and to investigate its effect on the development of nevirapine resistance in pregnant, HIV-infected women." | 9.17 | Effect of 7 days of phenytoin on the pharmacokinetics of and the development of resistance to single-dose nevirapine for perinatal HIV prevention: a randomized pilot trial. ( Aitken, S; Burger, DM; Chunda, C; Fillekes, Q; Gibb, DM; Kankasa, C; Kisanga, ER; Muro, EP; Thomason, MJ; Walker, AS, 2013) |
| "To confirm whether 7 days of phenytoin, an enzyme inducer, would decrease the elimination half-life of single-dose nevirapine and to investigate its effect on the development of nevirapine resistance in pregnant, HIV-infected women." | 5.17 | Effect of 7 days of phenytoin on the pharmacokinetics of and the development of resistance to single-dose nevirapine for perinatal HIV prevention: a randomized pilot trial. ( Aitken, S; Burger, DM; Chunda, C; Fillekes, Q; Gibb, DM; Kankasa, C; Kisanga, ER; Muro, EP; Thomason, MJ; Walker, AS, 2013) |
| "Phenytoin appears to increase LPV clearance via CYP3A4 induction, which is not offset by the presence of low-dose RTV." | 2.71 | Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction. ( Bertz, RJ; Eron, JJ; Gaedigk, A; Kashuba, AD; Lim, ML; Min, SS; Robinson, M, 2004) |
| "Seizures are common in patients infected with human immunodeficiency virus (HIV)." | 1.30 | Elevated free phenytoin and free valproic acid concentrations in sera of patients infected with human immunodeficiency virus. ( Dasgupta, A; McLemore, JL, 1998) |
| "New-onset seizures are infrequent in patients with HIV." | 1.30 | Prospective study of new-onset seizures in patients with human immunodeficiency virus infection: etiologic and clinical aspects. ( Barrio, JL; Domingo, P; Escartin, A; Fuster, M; Iranzo, A; Marti-Fàbregas, J; Pascual-Sedano, B; Sambeat, MA, 1999) |
| "However, we encountered a case of seizure recurrence caused by a lowered phenytoin level after initiation of nelfinavir." | 1.30 | A generalized seizure following initiation of nelfinavir in a patient with human immunodeficiency virus type 1 infection, suspected due to interaction between nelfinavir and phenytoin. ( Aoki, M; Honda, M; Oka, S; Yasuoka, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Keel, BR | 1 |
| Payne, CL | 1 |
| Fillekes, Q | 1 |
| Muro, EP | 1 |
| Chunda, C | 1 |
| Aitken, S | 1 |
| Kisanga, ER | 1 |
| Kankasa, C | 1 |
| Thomason, MJ | 1 |
| Gibb, DM | 1 |
| Walker, AS | 1 |
| Burger, DM | 1 |
| Karthik, SV | 1 |
| Lim, ML | 1 |
| Min, SS | 1 |
| Eron, JJ | 1 |
| Bertz, RJ | 1 |
| Robinson, M | 1 |
| Gaedigk, A | 1 |
| Kashuba, AD | 1 |
| Bedimo, RJ | 1 |
| Geisler, WM | 1 |
| Robertson, SM | 1 |
| Penzak, SR | 1 |
| Lane, J | 1 |
| Pau, AK | 1 |
| Mican, JM | 1 |
| Lee, KC | 1 |
| Garcia, PA | 1 |
| Alldredge, BK | 1 |
| Spak, CW | 1 |
| Dhanireddy, S | 1 |
| Kosel, BW | 1 |
| Dasgupta, A | 1 |
| McLemore, JL | 1 |
| Pascual-Sedano, B | 1 |
| Iranzo, A | 1 |
| Marti-Fàbregas, J | 1 |
| Domingo, P | 1 |
| Escartin, A | 1 |
| Fuster, M | 1 |
| Barrio, JL | 1 |
| Sambeat, MA | 1 |
| Honda, M | 1 |
| Yasuoka, A | 1 |
| Aoki, M | 1 |
| Oka, S | 1 |
| Brooks, J | 1 |
| Daily, J | 1 |
| Schwamm, L | 1 |
| Lehr, HA | 1 |
| Zimmer, JP | 1 |
| Hübner, C | 1 |
| Ballmann, M | 1 |
| Hachmann, W | 1 |
| Vogel, W | 1 |
| Baisch, H | 1 |
| Hartter, P | 1 |
| Albani, M | 1 |
| Kohlschütter, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Phenytoin on the Pharmacokinetics of Nevirapine and the Development of Nevirapine Resistance After a Single Dose Nevirapine (VIramune®), Which is Part of ARV Prophylaxis for PMTCT in Moshi, TAnzania, and in Lusaka, Zambia (VITA2 Trial)[NCT01187719] | Phase 2 | 66 participants (Actual) | Interventional | 2010-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for phenytoin and HIV Infections
| Article | Year |
|---|---|
A potentially significant interaction between efavirenz and phenytoin: a case report and review of the literature.
Topics: Adult; Alkynes; Anti-HIV Agents; Anticonvulsants; Benzoxazines; Cyclopropanes; Drug Interactions; HI | 2005 |
2 trials available for phenytoin and HIV Infections
| Article | Year |
|---|---|
Effect of 7 days of phenytoin on the pharmacokinetics of and the development of resistance to single-dose nevirapine for perinatal HIV prevention: a randomized pilot trial.
Topics: Adult; Anti-HIV Agents; Anticonvulsants; Drug Interactions; Drug Resistance, Viral; Female; Half-Lif | 2013 |
Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction.
Topics: Adult; Anticonvulsants; Cytochrome P-450 Enzyme System; Drug Interactions; Female; HIV Infections; H | 2004 |
11 other studies available for phenytoin and HIV Infections
| Article | Year |
|---|---|
Anticonvulsant hypersensitivity syndrome (AHS): a case report.
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Exanthema; Fe | 2013 |
Emerging challenges in cervical lymphadenopathy.
Topics: HIV Infections; Humans; Lymphatic Diseases; Mycobacterium Infections; Neck; Phenytoin; Seizures | 2003 |
Phenytoin hypersensitivity syndrome masquerading as fever and systemic illness of unknown origin in an HIV-infected patient.
Topics: Adult; Anticonvulsants; Drug Hypersensitivity; Female; Fever of Unknown Origin; HIV Infections; Huma | 2005 |
Clinical features of status epilepticus in patients with HIV infection.
Topics: Adult; Anti-Retroviral Agents; Anticonvulsants; Benzodiazepines; Brain Neoplasms; Central Nervous Sy | 2005 |
Clinical interaction between efavirenz and phenytoin.
Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Interactions; Drug Monitoring; HI | 2008 |
Elevated free phenytoin and free valproic acid concentrations in sera of patients infected with human immunodeficiency virus.
Topics: Anticonvulsants; Chemistry, Pharmaceutical; HIV Infections; Humans; Phenytoin; Polypharmacy; Seizure | 1998 |
Prospective study of new-onset seizures in patients with human immunodeficiency virus infection: etiologic and clinical aspects.
Topics: Adult; Anticonvulsants; Antiviral Agents; Cerebral Cortex; Female; HIV Infections; Humans; Male; Met | 1999 |
A generalized seizure following initiation of nelfinavir in a patient with human immunodeficiency virus type 1 infection, suspected due to interaction between nelfinavir and phenytoin.
Topics: Adult; Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Follow-Up Studies; HIV Infecti | 1999 |
ICAAC: nelfinavir interacts with statins and an antiseizure drug.
Topics: Anticholesteremic Agents; Anticonvulsants; Atorvastatin; Drug Interactions; Heptanoic Acids; HIV Inf | 2000 |
Protease inhibitors and anticonvulsants.
Topics: Anti-HIV Agents; Anticonvulsants; Carbamazepine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-45 | 1997 |
Decreased binding of HIV-1 and vasoactive intestinal peptide following plasma membrane fluidization of CD4+ cells by phenytoin.
Topics: Adsorption; CD4 Antigens; CD4-Positive T-Lymphocytes; Cell Cycle; Cell Membrane; Cells, Cultured; Fl | 1990 |