phenytoin has been researched along with Glioma in 37 studies
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seizures are common in patients with gliomas, and phenytoin (PHT) is frequently used to control tumor-related seizures." | 9.14 | Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. ( Barbaro, N; Burt, M; Chakalian, L; Chang, E; Chang, S; Lamborn, KR; Lim, DA; McDermott, MW; Tarapore, P, 2009) |
| "In this study, patients with glioma treated with levetiracetam and phenytoin had similar seizure control." | 7.76 | Seizures in patients with glioma treated with phenytoin and levetiracetam. ( Anderson, SK; Lachance, DH; Merrell, RT; Meyer, FB, 2010) |
| "The aim of this study was to investigate the antimigratory and antiinvasive potential of vincristine sulfate (VCR) on human glioma cells and to analyze whether phenytoin (5,5-diphenylhydantoin; DPH) might act synergistically with VCR." | 7.69 | Differential effects of vincristine and phenytoin on the proliferation, migration, and invasion of human glioma cell lines. ( Haugland, HK; Laerum, OD; Roosen, K; Saraste, J; Tonn, JC, 1995) |
| "The action of phenytoin on the inward calcium current (ICa) was studied in cells of the clonal mouse neuroblastoma X rat glioma hybrid line 108CC5 by the suction pipette technique for internal perfusion and voltage clamp." | 7.67 | Calcium channel block by phenytoin in neuroblastoma x glioma hybrid cells. ( Bodewei, R; Hering, S; Schubert, B; Winkler, J; Wollenberger, A, 1985) |
| " Eighteen patients had pharmacokinetic assays of Paclitaxel levels." | 6.73 | Fractionated stereotactic radiotherapy boost and weekly paclitaxel in malignant gliomas clinical and pharmacokinetics results. ( Ashamalla, H; Colella, F; Dosik, D; Guriguis, A; Krishnamurthy, M; Lavaf, A; Lewis, L; Mokhtar, B; Nasr, H; Saad, N; Zaki, B, 2007) |
| " The radiation dosage in each group was equal to 1702 ret." | 6.65 | The Cambridge glioma trial of misonidazole and radiation therapy with associated pharmacokinetic studies. ( Bleehen, NM, 1980) |
| "The population pharmacokinetic model reported here was developed using data from 2 phase 2 trials of irinotecan for treatment of malignant glioma to quantify the impact of concomitant therapy with enzyme-inducing antiepileptic drugs (EIAEDs) on irinotecan pharmacokinetics." | 5.20 | Quantification of the impact of enzyme-inducing antiepileptic drugs on irinotecan pharmacokinetics and SN-38 exposure. ( Ames, MM; Berg, AK; Buckner, JC; Galanis, E; Jaeckle, KA; Reid, JM, 2015) |
| " Therefore, the authors conducted a prospective, randomized trial examining the use of phenytoin for postoperative seizure prophylaxis in patients undergoing resection for supratentorial brain metastases or gliomas." | 5.17 | A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors. ( Forman, A; Graham, S; Heimberger, AB; Hess, K; Lang, FF; McCutcheon, IE; Prabhu, SS; Qiao, W; Sawaya, R; Suki, D; Trinh, VT; Wang, X; Weinberg, JS; Wu, AS, 2013) |
| "Seizures are common in patients with gliomas, and phenytoin (PHT) is frequently used to control tumor-related seizures." | 5.14 | Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. ( Barbaro, N; Burt, M; Chakalian, L; Chang, E; Chang, S; Lamborn, KR; Lim, DA; McDermott, MW; Tarapore, P, 2009) |
| "In this study, patients with glioma treated with levetiracetam and phenytoin had similar seizure control." | 3.76 | Seizures in patients with glioma treated with phenytoin and levetiracetam. ( Anderson, SK; Lachance, DH; Merrell, RT; Meyer, FB, 2010) |
| "The aim of this study was to investigate the antimigratory and antiinvasive potential of vincristine sulfate (VCR) on human glioma cells and to analyze whether phenytoin (5,5-diphenylhydantoin; DPH) might act synergistically with VCR." | 3.69 | Differential effects of vincristine and phenytoin on the proliferation, migration, and invasion of human glioma cell lines. ( Haugland, HK; Laerum, OD; Roosen, K; Saraste, J; Tonn, JC, 1995) |
| " High-dose tamoxifen was recently reported as a novel treatment for patients with malignant gliomas who have failed standard therapies." | 3.69 | High-dose tamoxifen in treatment of brain tumors: interaction with antiepileptic drugs. ( Couldwell, WT; Dyck, P; Hinton, DR; Rabinowicz, AL, 1995) |
| "The action of phenytoin on the inward calcium current (ICa) was studied in cells of the clonal mouse neuroblastoma X rat glioma hybrid line 108CC5 by the suction pipette technique for internal perfusion and voltage clamp." | 3.67 | Calcium channel block by phenytoin in neuroblastoma x glioma hybrid cells. ( Bodewei, R; Hering, S; Schubert, B; Winkler, J; Wollenberger, A, 1985) |
| " Eighteen patients had pharmacokinetic assays of Paclitaxel levels." | 2.73 | Fractionated stereotactic radiotherapy boost and weekly paclitaxel in malignant gliomas clinical and pharmacokinetics results. ( Ashamalla, H; Colella, F; Dosik, D; Guriguis, A; Krishnamurthy, M; Lavaf, A; Lewis, L; Mokhtar, B; Nasr, H; Saad, N; Zaki, B, 2007) |
| " The radiation dosage in each group was equal to 1702 ret." | 2.65 | The Cambridge glioma trial of misonidazole and radiation therapy with associated pharmacokinetic studies. ( Bleehen, NM, 1980) |
| "During follow-up, seizures occurred in 48." | 1.42 | Epilepsy in patients with gliomas: incidence and control of seizures. ( Hasegawa, Y; Iuchi, T; Kawasaki, K; Sakaida, T, 2015) |
| "Phenytoin was most commonly implicated (93 %) in rash formation compared with other AEDs (P < 0." | 1.40 | EMPACT syndrome: limited evidence despite a high-risk cohort. ( Barker, CA; Bishop, AJ; Chang, M; Lacouture, ME, 2014) |
| "Levetiracetam was more likely to be used in children who received chemotherapy or radiation therapy (8/14, or 57%) than in those who did not receive adjuvant therapies (3/18, or 17%) (P = 0." | 1.35 | The use of antiepileptic drugs in pediatric brain tumor patients. ( Kan, L; Levy, AS; Maytal, J; Shinnar, S; Sogawa, Y, 2009) |
| "Phenytoin is a highly effective anticonvulsant agent that is widely administrated to prevent some kinds of patients with brain tumor." | 1.27 | [Effects of phenytoin on cell-mediated immunity]. ( Matsui, Y; Miyao, Y; Mogami, H; Okamoto, Y; Shimizu, K; Tamura, K; Tsuda, N; Yamada, M, 1987) |
| "Patients without a history of seizures preoperatively had a similar incidence of seizures postoperatively, whether anticonvulsant medications were prescribed prophylactically or not." | 1.26 | The role of anticonvulsant medications in the management of patients with anaplastic gliomas. ( Dudka, L; Mahaley, MS, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (40.54) | 18.7374 |
| 1990's | 7 (18.92) | 18.2507 |
| 2000's | 7 (18.92) | 29.6817 |
| 2010's | 8 (21.62) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khandelwal, A | 1 |
| Sokhal, N | 1 |
| Kumar, N | 1 |
| Singh, S | 1 |
| Sokhal, S | 1 |
| Laghari, AA | 1 |
| Ahmed, SI | 1 |
| Qadeer, N | 1 |
| Shamim, MS | 1 |
| Bishop, AJ | 1 |
| Chang, M | 1 |
| Lacouture, ME | 1 |
| Barker, CA | 1 |
| Iuchi, T | 1 |
| Hasegawa, Y | 1 |
| Kawasaki, K | 1 |
| Sakaida, T | 1 |
| Berg, AK | 1 |
| Buckner, JC | 1 |
| Galanis, E | 1 |
| Jaeckle, KA | 1 |
| Ames, MM | 1 |
| Reid, JM | 1 |
| Lim, DA | 1 |
| Tarapore, P | 1 |
| Chang, E | 1 |
| Burt, M | 1 |
| Chakalian, L | 1 |
| Barbaro, N | 1 |
| Chang, S | 1 |
| Lamborn, KR | 1 |
| McDermott, MW | 1 |
| Sogawa, Y | 1 |
| Kan, L | 1 |
| Levy, AS | 1 |
| Maytal, J | 1 |
| Shinnar, S | 1 |
| Merrell, RT | 1 |
| Anderson, SK | 1 |
| Meyer, FB | 1 |
| Lachance, DH | 1 |
| Hefti, M | 1 |
| Albert, I | 1 |
| Luginbuehl, V | 1 |
| Wu, AS | 1 |
| Trinh, VT | 1 |
| Suki, D | 1 |
| Graham, S | 1 |
| Forman, A | 1 |
| Weinberg, JS | 1 |
| McCutcheon, IE | 1 |
| Prabhu, SS | 1 |
| Heimberger, AB | 1 |
| Sawaya, R | 1 |
| Wang, X | 1 |
| Qiao, W | 1 |
| Hess, K | 1 |
| Lang, FF | 1 |
| Kuhn, JG | 1 |
| Citerio, G | 1 |
| Nobili, A | 1 |
| Airoldi, L | 1 |
| Pastorelli, R | 1 |
| Patruno, A | 1 |
| MARX, GF | 1 |
| SCHEINBERG, L | 1 |
| ROMNEY, SL | 1 |
| Ashamalla, H | 1 |
| Zaki, B | 1 |
| Mokhtar, B | 1 |
| Lewis, L | 1 |
| Lavaf, A | 1 |
| Nasr, H | 1 |
| Colella, F | 1 |
| Dosik, D | 1 |
| Krishnamurthy, M | 1 |
| Saad, N | 1 |
| Guriguis, A | 1 |
| Walker, MD | 1 |
| Strike, TA | 1 |
| Sayk, J | 1 |
| Kmietzyk, HJ | 1 |
| Nelson, DF | 1 |
| Gillespie, BW | 1 |
| Diener, MD | 1 |
| Davis, DR | 1 |
| Wasserman, T | 1 |
| Phillips, TL | 1 |
| Stetz, J | 1 |
| Bleehen, NM | 1 |
| Bamberg, M | 1 |
| Tamulevicius, P | 1 |
| Streffer, C | 1 |
| Scherer, E | 1 |
| Mahaley, MS | 1 |
| Dudka, L | 1 |
| Tonn, JC | 1 |
| Haugland, HK | 1 |
| Saraste, J | 1 |
| Roosen, K | 1 |
| Laerum, OD | 1 |
| Rabinowicz, AL | 1 |
| Hinton, DR | 1 |
| Dyck, P | 1 |
| Couldwell, WT | 1 |
| Ständer, M | 1 |
| Dichgans, J | 1 |
| Weller, M | 1 |
| Arroyo, S | 1 |
| Rumiá, J | 1 |
| Martínez, I | 1 |
| Ribalta, T | 1 |
| Yamada, M | 2 |
| Ohkawa, M | 1 |
| Tamura, K | 2 |
| Mabuchi, E | 1 |
| Kishima, H | 1 |
| Tamura, M | 1 |
| Shimizu, K | 2 |
| Mathijssen, RH | 1 |
| Sparreboom, A | 1 |
| Dumez, H | 1 |
| van Oosterom, AT | 1 |
| de Bruijn, EA | 1 |
| Tilbury, RS | 1 |
| Van Buren, JM | 1 |
| Ajmone-Marsan, C | 1 |
| Mutsuga, N | 1 |
| Sadowsky, D | 1 |
| Haider, Y | 1 |
| Abbott, RJ | 1 |
| Wakisaka, S | 1 |
| Shimauchi, M | 1 |
| Kaji, Y | 1 |
| Nonaka, A | 1 |
| Kinoshita, K | 1 |
| Shaw, MD | 1 |
| Bodewei, R | 1 |
| Hering, S | 1 |
| Schubert, B | 1 |
| Winkler, J | 1 |
| Wollenberger, A | 1 |
| Jou, TC | 1 |
| Wei, JW | 1 |
| Peng, TI | 1 |
| Okamoto, Y | 1 |
| Miyao, Y | 1 |
| Matsui, Y | 1 |
| Tsuda, N | 1 |
| Mogami, H | 1 |
| Rektor, I | 1 |
| Bednarík, J | 1 |
| Svejdová, M | 1 |
| Haring, RD | 1 |
| Simmons, FB | 1 |
| Tenser, RB | 1 |
| Corbett, JJ | 1 |
1 review available for phenytoin and Glioma
| Article | Year |
|---|---|
Choice of therapeutic anti-seizure medication in patients with brain tumour.
Topics: Anticonvulsants; Brain Neoplasms; Drug Therapy, Combination; Epilepsy; Gabapentin; Glioma; Humans; L | 2019 |
8 trials available for phenytoin and Glioma
| Article | Year |
|---|---|
Quantification of the impact of enzyme-inducing antiepileptic drugs on irinotecan pharmacokinetics and SN-38 exposure.
Topics: Adult; Aged; Anticonvulsants; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Carb | 2015 |
Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Neoplasms; Craniotomy; Female; Glioma; Humans | 2009 |
A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Bayes Theorem; Brain Neoplasms; Craniot | 2013 |
Influence of anticonvulsants on the metabolism and elimination of irinotecan. A North American Brain Tumor Consortium preliminary report.
Topics: Anticonvulsants; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Carbamazepine; Do | 2002 |
Fractionated stereotactic radiotherapy boost and weekly paclitaxel in malignant gliomas clinical and pharmacokinetics results.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Antineoplastic Agents, Phytogenic; Brain Neoplasms; | 2007 |
Is misonidazole neurotoxicity altered by the use of phenytoin and/or dexamethasone in RTOG 79-18 and RTOG 79-16?
Topics: Brain Neoplasms; Clinical Trials as Topic; Dexamethasone; Female; Glioma; Humans; Male; Middle Aged; | 1984 |
The Cambridge glioma trial of misonidazole and radiation therapy with associated pharmacokinetic studies.
Topics: Brain Neoplasms; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Glioma; Head an | 1980 |
Post-operative epilepsy and the efficacy of anticonvulsant therapy.
Topics: Anticonvulsants; Brain Neoplasms; Carbamazepine; Epilepsies, Partial; Follow-Up Studies; Glioma; Hum | 1990 |
28 other studies available for phenytoin and Glioma
| Article | Year |
|---|---|
Phenytoin-induced Excessive Sedation During Awake Craniotomy: An Unusual Observation.
Topics: Adult; Brain Neoplasms; Conscious Sedation; Consciousness Monitors; Craniotomy; Glioma; Humans; Male | 2019 |
EMPACT syndrome: limited evidence despite a high-risk cohort.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Neoplasms; Child; Cranial Irradia | 2014 |
Epilepsy in patients with gliomas: incidence and control of seizures.
Topics: Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Carbamazepine; Female; Glioma; Humans; Inci | 2015 |
The use of antiepileptic drugs in pediatric brain tumor patients.
Topics: Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Carbamazepine; Child; Drug Interactions; Fo | 2009 |
Seizures in patients with glioma treated with phenytoin and levetiracetam.
Topics: Adult; Aged; Anticonvulsants; Female; Glioma; Humans; Levetiracetam; Male; Middle Aged; Phenytoin; P | 2010 |
Phenytoin reduces 5-aminolevulinic acid-induced protoporphyrin IX accumulation in malignant glioma cells.
Topics: Aminolevulinic Acid; Anticonvulsants; Fluorescence; Glioma; Glutathione; Humans; Levetiracetam; Memb | 2012 |
Severe intoxication after phenytoin infusion: a preventable pharmacogenetic adverse reaction.
Topics: Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Brain Neoplasms; Chemical and Drug Induced Li | 2003 |
ANESTHETIC MANAGEMENT OF THE PARTURIENT WITH INTRACRANIAL TUMOR.
Topics: Anesthesia; Anesthesia, Endotracheal; Anesthesia, Spinal; Anesthetics; Angiography; Brain Neoplasms; | 1964 |
Misonidazole peripheral neuropathy: its relationship to plasma concentration and other drugs.
Topics: Adrenal Cortex Hormones; Barbiturates; Brain Neoplasms; Drug Interactions; Female; Glioma; Half-Life | 1980 |
[Survival period of patients with gliomata or glioblastomata under anti-convulsive therapy (author's transl)].
Topics: Adult; Brain Neoplasms; Epilepsy; Female; Glioblastoma; Glioma; Humans; Male; Phenytoin; Prognosis | 1981 |
[Clinical experiences with the radiosensitizer Misonidazol (author's transl)].
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Dexamethasone; Drug Interactions; Esophageal Neoplasms; Ex | 1981 |
The role of anticonvulsant medications in the management of patients with anaplastic gliomas.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain Neoplasms; Double-Blind Method; Frontal Lobe; Glioma | 1981 |
Differential effects of vincristine and phenytoin on the proliferation, migration, and invasion of human glioma cell lines.
Topics: Antineoplastic Agents; Cell Division; Cell Movement; Dose-Response Relationship, Drug; Drug Synergis | 1995 |
High-dose tamoxifen in treatment of brain tumors: interaction with antiepileptic drugs.
Topics: Adult; Brain Neoplasms; Cell Division; Drug Interactions; Glioma; Humans; Magnetic Resonance Imaging | 1995 |
Anticonvulsant drugs fail to modulate chemotherapy-induced cytotoxicity and growth inhibition of human malignant glioma cells.
Topics: Anticonvulsants; Antineoplastic Agents; Carbamazepine; Cell Division; Cell Survival; Glioma; Humans; | 1998 |
[Drug-resistant epilepsy].
Topics: Adult; Anticonvulsants; Brain Neoplasms; Calcinosis; Carbamazepine; Diagnosis, Differential; Drug Re | 1998 |
Anticonvulsant-induced suppression of IFN-gamma production by lymphocytes obtained from cervical lymph nodes in glioma-bearing mice.
Topics: Animals; Anticonvulsants; Brain; Brain Neoplasms; Disease Models, Animal; Glioma; Humans; Immunohist | 2000 |
Altered irinotecan metabolism in a patient receiving phenytoin.
Topics: Adult; Anticonvulsants; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Drug Inter | 2002 |
The Memorial Sloan-Kettering biomedical cyclotron facility:radioisotope production and labeled compounds.
Topics: Animals; Brain Neoplasms; Carbon Radioisotopes; Glioma; Haplorhini; Humans; Isotope Labeling; Macaca | 1978 |
Surgery of temporal lobe epilepsy.
Topics: Adolescent; Adult; Astrocytes; Brain Neoplasms; Cerebral Cortex; Child; Child, Preschool; Electroenc | 1975 |
Phenytoin-induced choreoathetosis.
Topics: Athetosis; Brain Neoplasms; Chorea; Female; Glioma; Humans; Middle Aged; Phenytoin | 1990 |
Acute phenytoin intoxication associated with the antineoplastic agent UFT.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; D | 1990 |
Calcium channel block by phenytoin in neuroblastoma x glioma hybrid cells.
Topics: Action Potentials; Animals; Anticonvulsants; Calcium; Calcium Channel Blockers; Glioma; Hybrid Cells | 1985 |
[Effects of phenobarbital and phenytoin on the growth morphology and some ATPase activities of rat brain astrocytes derived from normal newborn cerebrum and C6 glioma cells in culture].
Topics: Adenosine Triphosphatases; Animals; Astrocytes; Brain; Cell Division; Cells, Cultured; Glioma; Pheno | 1988 |
[Effects of phenytoin on cell-mediated immunity].
Topics: Animals; Cells, Cultured; Cytotoxicity, Immunologic; Female; Glioma; Immunity, Cellular; Interleukin | 1987 |
[Anticonvulsants in the therapy of glioblastomas].
Topics: Adult; Anticonvulsants; Brain Neoplasms; Carbamazepine; Combined Modality Therapy; Drug Therapy, Com | 1986 |
Cerebellar defects detectable by electronystagmography calibration.
Topics: Adolescent; Adult; Aged; Astrocytoma; Blindness; Brain Diseases; Cerebellar Ataxia; Cerebellar Disea | 1973 |
Myokymia and facial contraction in brain stem glioma. An electromyographic study.
Topics: Action Potentials; Adult; Brain Neoplasms; Carbamazepine; Diazepam; Edrophonium; Electromyography; F | 1974 |