phenytoin has been researched along with Glaucoma in 12 studies
Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study tested the hypothesis that sodium channel blockade with phenytoin would result in neuroprotection of retinal ganglion cells (RGCs) and optic nerve axons in an experimental model of glaucoma." | 7.73 | Neuroprotection by sodium channel blockade with phenytoin in an experimental model of glaucoma. ( Hains, BC; Waxman, SG, 2005) |
| " This study tested the hypothesis that sodium channel blockade with phenytoin would result in neuroprotection of retinal ganglion cells (RGCs) and optic nerve axons in an experimental model of glaucoma." | 3.73 | Neuroprotection by sodium channel blockade with phenytoin in an experimental model of glaucoma. ( Hains, BC; Waxman, SG, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (91.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| PECZON, JD | 1 |
| GRANT, WM | 1 |
| Hains, BC | 1 |
| Waxman, SG | 1 |
| Tunnessen, WW | 1 |
| Lowenstein, EH | 1 |
| Walson, P | 1 |
| Trinca, C | 1 |
| Bressler, R | 1 |
| Enoch, JM | 1 |
| Lawrence, B | 1 |
| Vesell, ES | 1 |
| Podos, SM | 5 |
| Becker, B | 4 |
| Asseff, CF | 1 |
| Cooper, DG | 2 |
| Evans, DA | 1 |
| Beaty, C | 1 |
| Krupin, T | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Cohort Study of Association Between Steady State Phenytoin Treatment and Better Clinical Parameters of Glaucoma[NCT00739154] | 200 participants (Anticipated) | Observational | 2008-11-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for phenytoin and Glaucoma
| Article | Year |
|---|---|
SEDATIVES, STIMULANTS, AND INTRAOCULAR PRESSURE IN GLAUCOMA.
Topics: Anticonvulsants; Barbiturates; Caffeine; Central Nervous System Stimulants; Dextroamphetamine; Glauc | 1964 |
Advances in pharmacogenetics.
Topics: Alcohol Oxidoreductases; Catalase; Cholinesterases; Dicumarol; Diseases in Twins; Drug Hypersensitiv | 1973 |
Glaucoma.
Topics: Acid-Base Equilibrium; Animals; Contact Lenses, Hydrophilic; Delayed-Action Preparations; Glaucoma; | 1973 |
Genetic factors in drug therapy.
Topics: Adolescent; Aged; Alcohol Oxidoreductases; Animals; Anticoagulants; Child; Female; Glaucoma; Humans; | 1969 |
1 trial available for phenytoin and Glaucoma
| Article | Year |
|---|---|
A erimetric technique believed to test receptive field properties: sequential evaluation glaucoma and other conditions.
Topics: Aged; Amblyopia; Clinical Trials as Topic; Female; Glaucoma; Humans; Hydroxocobalamin; Male; Middle | 1975 |
7 other studies available for phenytoin and Glaucoma
| Article | Year |
|---|---|
Neuroprotection by sodium channel blockade with phenytoin in an experimental model of glaucoma.
Topics: Administration, Oral; Animals; Axons; Cell Count; Cell Survival; Disease Models, Animal; Glaucoma; I | 2005 |
Letter: Glaucoma associated with the fetal hydantoin syndrome.
Topics: Adult; Female; Fetus; Glaucoma; Humans; Infant; Phenytoin; Pregnancy | 1976 |
New uses for phenytoin.
Topics: Arrhythmias, Cardiac; Diabetic Neuropathies; Digitalis Glycosides; Drug Evaluation; Epilepsy; Gastro | 1975 |
Plasma cortisol suppression in glaucoma.
Topics: Administration, Oral; Chromatography, Gas; Dexamethasone; Dose-Response Relationship, Drug; Feedback | 1973 |
Diphenylhydantoin and cortisol metabolism in glaucoma.
Topics: 17-Hydroxycorticosteroids; Dexamethasone; Glaucoma; Hydrocortisone; Hydroxycorticosteroids; Intraocu | 1972 |
Effect of diphenylhydantoin on dexamethasone suppression of plasma cortisol in primary open-angle glaucoma.
Topics: Depression, Chemical; Dexamethasone; Feedback; Fundus Oculi; Glaucoma; Glucose Tolerance Test; Human | 1971 |
Diphenylhydantoin and dexamethasone-induced changes of plasma cortisol: comparison of patients with and without glaucoma.
Topics: Chromatography, Gas; Dexamethasone; Glaucoma; Humans; Hydrocortisone; Phenytoin | 1971 |