phenytoin has been researched along with Gingival Overgrowth in 64 studies
Gingival Overgrowth: Excessive growth of the gingiva either by an increase in the size of the constituent cells (GINGIVAL HYPERTROPHY) or by an increase in their number (GINGIVAL HYPERPLASIA). (From Jablonski's Dictionary of Dentistry, 1992, p574)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of folic acid (5mg/day) in combination with oral hygiene measures (group II) vis-a-vis oral hygiene measures alone (group I) in prevention of phenytoin-induced gingival overgrowth was investigated in a one-year follow-up study on sixty, 8-13-year-old epileptic children receiving phenytoin." | 9.11 | Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect. ( Chawla, HS; Gauba, K; Goyal, A; Prasad, VN; Singhi, P, 2004) |
| "Gingival overgrowth is a common adverse effect of therapy with Phenytoin, having important medical and cosmetic implications." | 8.88 | Phenytoin-induced gingival overgrowth. ( Arya, R; Gulati, S, 2012) |
| "Side effects of certain drugs such as cyclosporin A (CsA) and phenytoin may induce gingival overgrowth which in some instances become unacceptable to the patient because esthetic, functional, and other effects." | 8.80 | Reduction of severe gingival overgrowth in a kidney transplant patient by replacing cyclosporin A with tacrolimus. ( Arriba, L; de Andrés, A; Hernández, G; Lucas, M, 2000) |
| "At the moment there is no clear evidence with clinico-histological and immunohistochemical studies in animals to show the curcumin effect on the gingival overgrowth following phenytoin consumption." | 7.91 | Curcumin Effect on the Prevention of Gingival Overgrowth Following Phenytoin Consumption in Rats: A Clinicohistological and Immunohistochemical Study. ( Eftekharian, S; Feizi, F; Gholinia, H; Kazemi, S; Moghaddamnia, AA; Satari, FD; Seifi, S, 2019) |
| "This study represents the first mutation analysis of the SOS1 gene in phenytoin-induced gingival overgrowth epileptic patients." | 7.85 | Lack of pathogenic mutations in SOS1 gene in phenytoin-induced gingival overgrowth patients. ( Consoli, F; De Luca, A; Di Bonaventura, C; Giallonardo, AT; Guida, V; Margiotti, K; Pascolini, G; Pizzuti, A, 2017) |
| "In this study, we investigated the role of phenytoin (PHT) in death receptor-induced apoptosis of gingival fibroblasts to clarify the mechanism of PHT-induced gingival overgrowth." | 7.85 | Phenytoin-induced gingival overgrowth caused by death receptor pathway malfunction. ( Arikawa, K; Hiratsuka, K; Matsumoto, H; Nakayama, R; Nasu, I; Taguchi, C; Takeuchi, R, 2017) |
| "To identify the possible biological roles of keratinocyte growth factor (KGF), connective tissue growth factor (CTGF) and transforming growth factor-β (TGF-β) in cyclosporine-A (CsA) and phenytoin (PNT)-induced gingival overgrowth (GO) and to correlate them with each other." | 7.83 | Biological roles of KGF, CTGF and TGF-β in cyclosporine-A- and phenytoin- induced gingival overgrowth: A comparative experimental animal study. ( Abdul-Rahman, M; Al-Hamilly, NS; Grawish, ME; Mourad, MI; Radwan, LR, 2016) |
| "Drug-induced gingival overgrowth is caused by the antiseizure medication phenytoin, calcium channel blockers, and ciclosporin." | 7.81 | Prevention of phenytoin-induced gingival overgrowth by lovastatin in mice. ( Assaggaf, MA; Kantarci, A; Sume, SS; Trackman, PC, 2015) |
| "Eighteen epileptic patients had phenytoin-induced gingival overgrowth (PHT-GO), 20 patients with plaque-induced gingivitis (Gingivitis), and 20 periodontally and systemically healthy individuals (Control) were included in this study." | 7.80 | Role of nuclear factor kappa-B in phenytoin-induced gingival overgrowth. ( Albayrak, M; Arabaci, T; Ciçek, Y; Kara, A; Kizildağ, A; Köse, O, 2014) |
| "Gingival overgrowth (GO) may be related to the frequent use of certain medications, such as cyclosporin, phenytoin (PHT), and nifedipine, and is therefore denominated drug-induced GO." | 7.78 | Functional aesthetic treatment of patient with phenytoin-induced gingival overgrowth. ( Campos, N; da Silva, JB; Luvizuto, ER; Luvizuto, GC; Panzarini, SR; Poi, WR, 2012) |
| "There have been case reports of oral squamous cell carcinoma arising from gingival overgrowth induced by phenytoin--an antiepileptic drug." | 7.78 | Lack of mutation in p53 and H-ras genes in phenytoin induced gingival overgrowth suggests its non cancerous nature. ( Jayakumar, K; Jayaraman, B; Palaniyandi, A; Ramanathan, A; Thenumgal, SJ; Valiathan, GM, 2012) |
| "Phenytoin is widely used as an antiepileptic drug in clinic, but a common and well-known adverse effect of its administration is gingival overgrowth which may influence the aesthetics and function of the oral cavity." | 7.75 | [Research advances in the mechanism of phenytoin-induced gingival overgrowth]. ( Sun, QF; Yang, PS; Zhang, YH, 2009) |
| "We investigated the relationship between phenytoin-induced gingival overgrowth (GO) and the harboring of periodontal bacteria." | 7.73 | Relationship of periodontal bacteria and Porphyromonas gingivalis fimA variations with phenytoin-induced gingival overgrowth. ( Akiyama, S; Amano, A; Kato, T; Kimura, KR; Morisaki, I; Takada, Y, 2006) |
| "Phenytoin-induced gingival overgrowth is a well-known and frequently reported gingival lesion, which was first detected in 1939." | 7.72 | Phenytoin-induced gingival overgrowth in un-cooperated epilepsy patients. ( Cakmak, H; Gursoy, UK; Marakoglu, I; Marakoglu, K, 2004) |
| "To elucidate the involvement of bFGF (basic fibroblast growth factor) in the pathogenesis of phenytoin-induced gingival overgrowth, we measured the concentration of bFGF in the serum of 36 epileptic patients taking phenytoin and in 94 normal volunteers by enzyme-linked immunosorbent assay technique." | 7.70 | Increased bFGF level in the serum of patients with phenytoin-induced gingival overgrowth. ( Maita, E; Sasaki, T, 1998) |
| "The potential effect of co-medication with phenobarbitone, primidone and carbamazepine on plasma and saliva concentrations of 5-(4-hydroxyphenyl)-5-phenylhydantoin (4-HPPH), the major metabolite of phenytoin in man and on the incidence of phenytoin-induced gingival overgrowth was investigated in a group of 36 adult epileptic patients." | 7.70 | The effect of multiple anticonvulsant therapy on the expression of phenytoin-induced gingival overgrowth. ( Ball, DE; Kamali, F; McLaughlin, WS; Seymour, RA, 1999) |
| " The patient manifested marked gingival overgrowth compatible clinically and histologically with the overgrowth induced by phenytoin, cyclosporine and calcium channel blockers." | 7.69 | Vigabatrin-induced gingival overgrowth. ( Chaushu, G; Givol, N; Katz, J; Shemer, J; Taicher, S, 1997) |
| "A few case reports of oral squamous cell carcinomas arising from regions of phenytoin induced gingival overgrowth (GO), and overexpression of mitogenic factors and p53 have presented this condition as a pathology with potential to transform into malignancy." | 5.39 | Comprehensive mutation analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 genes is suggestive of a non- neoplastic nature of phenytoin induced gingival overgrowth. ( Jayesh, RS; Kumar, KS; Muthupalani, RS; Rajendran, S; Ramanathan, A; Swamikannu, B, 2013) |
| "Phenytoin is a commonly used anticonvulsant drug for the prevention of seizures." | 5.30 | Myofibroblasts in phenytoin-induced hyperplastic connective tissue in the rat and in human gingival overgrowth. ( Dill, RE; Iacopino, AM, 1997) |
| "Drug-induced gingival overgrowth (DIGO) is a frequent adverse medication reaction that is generally caused by cyclosporine, phenytoin, and nifedipine, which belong to the category of immunosuppressants, anticonvulsants, and calcium channel blockers, respectively." | 5.22 | Bibliometric analysis of research trends and characteristics of drug-induced gingival overgrowth. ( Song, J; Wang, X; Wu, J; Zhang, R; Zhu, J, 2022) |
| "The role of folic acid (5mg/day) in combination with oral hygiene measures (group II) vis-a-vis oral hygiene measures alone (group I) in prevention of phenytoin-induced gingival overgrowth was investigated in a one-year follow-up study on sixty, 8-13-year-old epileptic children receiving phenytoin." | 5.11 | Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect. ( Chawla, HS; Gauba, K; Goyal, A; Prasad, VN; Singhi, P, 2004) |
| " Phenytoin, cyclosporine-A and a variety of calcium channel blockers have been shown to produce gingival overgrowth." | 4.80 | [An increase in gingival volume induced by drugs (phenytoin, cyclosporine and calcium antagonists). A review of the literature]. ( Broccoletti, R; Carbone, M; Carrozzo, M; Gandolfo, S; Garzino-Demo, P, 1998) |
| "Side effects of certain drugs such as cyclosporin A (CsA) and phenytoin may induce gingival overgrowth which in some instances become unacceptable to the patient because esthetic, functional, and other effects." | 4.80 | Reduction of severe gingival overgrowth in a kidney transplant patient by replacing cyclosporin A with tacrolimus. ( Arriba, L; de Andrés, A; Hernández, G; Lucas, M, 2000) |
| "Drug-induced gingival overgrowth is an iatrogenic disease caused by the use of phenytoin, cyclosporine, nifedipine, and other medications in the susceptible patient." | 4.79 | Prevention and treatment considerations in patients with drug-induced gingival enlargement. ( Hall, EE, 1997) |
| "The active drugs lamotrigine, oxcarbazepine, and phenobarbital were significantly associated with gingival overgrowth in 61%, 71%, and 53% of cases, respectively, and phenytoin, valproic acid, and carbamazepine in 50%, 44%, and 32% of cases, respectively." | 4.02 | Gingival overgrowth induced by anticonvulsant drugs: A cross-sectional study on epileptic patients. ( Bonvento, G; Gallo, C; Mucignat-Caretta, C; Zagotto, G, 2021) |
| "Based on this methodology, it may be concluded that gingival overgrowths induced by cyclosporin, nifedipine and phenytoin are not associated with neither myofibroblast transdifferentiation, proliferation nor apoptosis of gingival connective cells in monkeys." | 3.88 | Effects of cyclosporin, nifedipine and phenytoin on gingival myofibroblast transdifferentiation in monkeys. ( Ervolino, E; Kanno, CM; Oliveira, JA; Soubhia, AMP, 2018) |
| "This study represents the first mutation analysis of the SOS1 gene in phenytoin-induced gingival overgrowth epileptic patients." | 3.85 | Lack of pathogenic mutations in SOS1 gene in phenytoin-induced gingival overgrowth patients. ( Consoli, F; De Luca, A; Di Bonaventura, C; Giallonardo, AT; Guida, V; Margiotti, K; Pascolini, G; Pizzuti, A, 2017) |
| "To identify the possible biological roles of keratinocyte growth factor (KGF), connective tissue growth factor (CTGF) and transforming growth factor-β (TGF-β) in cyclosporine-A (CsA) and phenytoin (PNT)-induced gingival overgrowth (GO) and to correlate them with each other." | 3.83 | Biological roles of KGF, CTGF and TGF-β in cyclosporine-A- and phenytoin- induced gingival overgrowth: A comparative experimental animal study. ( Abdul-Rahman, M; Al-Hamilly, NS; Grawish, ME; Mourad, MI; Radwan, LR, 2016) |
| "Drug-induced gingival overgrowth is caused by the antiseizure medication phenytoin, calcium channel blockers, and ciclosporin." | 3.81 | Prevention of phenytoin-induced gingival overgrowth by lovastatin in mice. ( Assaggaf, MA; Kantarci, A; Sume, SS; Trackman, PC, 2015) |
| "Eighteen epileptic patients had phenytoin-induced gingival overgrowth (PHT-GO), 20 patients with plaque-induced gingivitis (Gingivitis), and 20 periodontally and systemically healthy individuals (Control) were included in this study." | 3.80 | Role of nuclear factor kappa-B in phenytoin-induced gingival overgrowth. ( Albayrak, M; Arabaci, T; Ciçek, Y; Kara, A; Kizildağ, A; Köse, O, 2014) |
| "Both phenytoin (PhT) and cyclosporine (CsA) have been related to gingival overgrowth, but the presence and incidence of cytokines in gingival tissues are associated with different mechanisms." | 3.80 | Effects of cyclosporine and phenytoin on biomarker expressions in gingival fibroblasts of children and adults: an in vitro study. ( Namdari, M; Rezazadeh, F; Salman, BN; Vahabi, S, 2014) |
| "Gingival overgrowth is caused in response to the antiepileptic drug phenytoin (PHT)." | 3.80 | Inhibition of G₁ cell cycle arrest in human gingival fibroblasts exposed to phenytoin. ( Akimoto, Y; Fujii, A; Matsumoto, H; Takeuchi, R, 2014) |
| "Drug-influenced gingival overgrowth is an unaesthetic overgrowth of gingiva principally associated with intake of drugs like phenytoin, cyclosporin A and nifedipine." | 3.78 | Gingival overgrowth in partially edentulous ridges in an elderly female patient with epilepsy: a case report. ( Dhingra, K; Prakash, S, 2012) |
| "Gingival overgrowth is an adverse drug reaction (ADR) well known with phenytoin, cyclosporine or calcium channel blockers but can be related to other drugs." | 3.78 | Drug-induced gingival overgrowth: a study in the French Pharmacovigilance Database. ( Bagheri, H; Bondon-Guitton, E; Montastruc, JL, 2012) |
| " Medication with phenytoin, nifedipine, and cyclosporine-A often causes gingival overgrowth." | 3.76 | Epithelial to mesenchymal transition in gingival overgrowth. ( Hasturk, H; Kantarci, A; Lee, A; Sume, SS; Trackman, PC, 2010) |
| "Gingival overgrowth is a common side-effect of administration of the immunosuppressant cyclosporin A and the anti-epileptic drug phenytoin." | 3.75 | Cyclosporin A and phenytoin modulate inflammatory responses. ( Hara, Y; Kaneko, T; Ozaki, Y; Suzuki, AM; Yoshimura, A, 2009) |
| "We investigated the relationship between phenytoin-induced gingival overgrowth (GO) and the harboring of periodontal bacteria." | 3.73 | Relationship of periodontal bacteria and Porphyromonas gingivalis fimA variations with phenytoin-induced gingival overgrowth. ( Akiyama, S; Amano, A; Kato, T; Kimura, KR; Morisaki, I; Takada, Y, 2006) |
| "Gingival overgrowth (GO) is a serious adverse effect associated with the administration of phenytoin (PHT), with PHT-induced GO characterized by a massive accumulation of extracellular matrix components, especially collagen, in gingival connective tissues." | 3.73 | Impaired degradation of matrix collagen in human gingival fibroblasts by the antiepileptic drug phenytoin. ( Amano, A; Inaba, H; Kato, T; Kawai, S; Morisaki, I; Okahashi, N, 2005) |
| "The aim of this investigation is to study androgen metabolism in gingival fibroblasts in response to phenytoin, oestradiol and the antioestrogen tamoxifen, in order to establish the possible role of hormones in the aetiopathogenesis of phenytoin-induced gingival overgrowth." | 3.72 | Modulation of androgen metabolism by phenytoin, oestradiol and tamoxifen in human gingival fibroblasts. ( Soory, M; Tilakaratne, A, 2003) |
| "Phenytoin-induced gingival overgrowth is a well-known and frequently reported gingival lesion, which was first detected in 1939." | 3.72 | Phenytoin-induced gingival overgrowth in un-cooperated epilepsy patients. ( Cakmak, H; Gursoy, UK; Marakoglu, I; Marakoglu, K, 2004) |
| "This investigation attempts to identify the role of the alkaline phosphatase inhibitor levamisole (L) and the antiandrogen finasteride (F) on 5alpha-reductase activity in gingival fibroblasts, to elucidate mechanisms for phenytoin-induced gingival overgrowth." | 3.71 | Phenytoin-mediated androgen metabolism in gingival fibroblasts. Effects of the antiandrogen finasteride and the alkaline phosphatase inhibitor levamisole. ( Soory, M; Suchak, A, 2002) |
| "The aim was to elucidate mechanisms for phenytoin-induced gingival overgrowth, using effects of type 1 human mast cell (HMC-1) supernatant and histamine on the expression of 5alpha-reductase in human gingival fibroblasts (HGF), and the effects of phenytoin on this activity." | 3.71 | The effects of human mast-cell products and of phenytoin on androgen 5alpha-reductase expression in human gingival fibroblasts. ( Soory, M; Suchak, A, 2001) |
| "The data from the present study show significantly higher CTGF staining in phenytoin-induced gingival overgrowth tissues compared to controls, cyclosporin A-, or nifedipine-induced gingival overgrowth." | 3.71 | Connective tissue growth factor in drug-induced gingival overgrowth. ( Firatli, E; Hong, HH; Kantarci, A; Sheff, MC; Trackman, PC; Uygur, C; Uzel, MI, 2001) |
| "To elucidate the involvement of bFGF (basic fibroblast growth factor) in the pathogenesis of phenytoin-induced gingival overgrowth, we measured the concentration of bFGF in the serum of 36 epileptic patients taking phenytoin and in 94 normal volunteers by enzyme-linked immunosorbent assay technique." | 3.70 | Increased bFGF level in the serum of patients with phenytoin-induced gingival overgrowth. ( Maita, E; Sasaki, T, 1998) |
| "The potential effect of co-medication with phenobarbitone, primidone and carbamazepine on plasma and saliva concentrations of 5-(4-hydroxyphenyl)-5-phenylhydantoin (4-HPPH), the major metabolite of phenytoin in man and on the incidence of phenytoin-induced gingival overgrowth was investigated in a group of 36 adult epileptic patients." | 3.70 | The effect of multiple anticonvulsant therapy on the expression of phenytoin-induced gingival overgrowth. ( Ball, DE; Kamali, F; McLaughlin, WS; Seymour, RA, 1999) |
| " The patient manifested marked gingival overgrowth compatible clinically and histologically with the overgrowth induced by phenytoin, cyclosporine and calcium channel blockers." | 3.69 | Vigabatrin-induced gingival overgrowth. ( Chaushu, G; Givol, N; Katz, J; Shemer, J; Taicher, S, 1997) |
| "A few case reports of oral squamous cell carcinomas arising from regions of phenytoin induced gingival overgrowth (GO), and overexpression of mitogenic factors and p53 have presented this condition as a pathology with potential to transform into malignancy." | 1.39 | Comprehensive mutation analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 genes is suggestive of a non- neoplastic nature of phenytoin induced gingival overgrowth. ( Jayesh, RS; Kumar, KS; Muthupalani, RS; Rajendran, S; Ramanathan, A; Swamikannu, B, 2013) |
| "Phenytoin was used as a positive control." | 1.31 | Comparative study of calcium-channel blockers on cell proliferation, DNA and collagen syntheses, and EGF receptors of cultured gingival fibroblasts derived from human nifedipine, nicardipine and nisoldipine responders. ( Akimoto, Y; Fujii, A; Matsumoto, H; Noji, I, 2001) |
| "Phenytoin is a commonly used anticonvulsant drug for the prevention of seizures." | 1.30 | Myofibroblasts in phenytoin-induced hyperplastic connective tissue in the rat and in human gingival overgrowth. ( Dill, RE; Iacopino, AM, 1997) |
| "Nifedipine and phenytoin were also tested to further support findings with CsA." | 1.30 | Regulation of gingival fibroblast interleukin-6 secretion by cyclosporine A. ( Dongari-Bagtzoglou, AI; Morton, RS, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (20.31) | 18.2507 |
| 2000's | 22 (34.38) | 29.6817 |
| 2010's | 24 (37.50) | 24.3611 |
| 2020's | 5 (7.81) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, R | 1 |
| Wu, J | 1 |
| Zhu, J | 1 |
| Wang, X | 1 |
| Song, J | 1 |
| Deng, YT | 1 |
| Wu, KJ | 1 |
| Kuo, MY | 1 |
| Karn, M | 1 |
| Sah, R | 1 |
| Sapkota, S | 1 |
| Sridharan, S | 1 |
| Nunna, P | 1 |
| Jaicob, TE | 1 |
| Agustine, D | 1 |
| Shetty, V | 1 |
| Srirangarajan, D | 1 |
| Eftekharian, S | 1 |
| Seifi, S | 1 |
| Satari, FD | 1 |
| Moghaddamnia, AA | 1 |
| Feizi, F | 1 |
| Kazemi, S | 1 |
| Gholinia, H | 1 |
| Lauritano, D | 1 |
| Moreo, G | 1 |
| Limongelli, L | 1 |
| Tregambi, E | 1 |
| Palmieri, A | 1 |
| Carinci, F | 1 |
| Gallo, C | 1 |
| Bonvento, G | 1 |
| Zagotto, G | 1 |
| Mucignat-Caretta, C | 1 |
| Margiotti, K | 1 |
| Pascolini, G | 1 |
| Consoli, F | 1 |
| Guida, V | 1 |
| Di Bonaventura, C | 1 |
| Giallonardo, AT | 1 |
| Pizzuti, A | 1 |
| De Luca, A | 1 |
| López-González, MJ | 1 |
| Luis, E | 1 |
| Fajardo, O | 1 |
| Meseguer, V | 1 |
| Gers-Barlag, K | 1 |
| Niñerola, S | 1 |
| Viana, F | 1 |
| Kim, SS | 1 |
| Nikoloudaki, G | 1 |
| Darling, M | 1 |
| Rieder, MJ | 1 |
| Hamilton, DW | 1 |
| Hughes, FJ | 1 |
| Bartold, PM | 2 |
| Kanno, CM | 2 |
| Oliveira, JA | 2 |
| Ervolino, E | 1 |
| Soubhia, AMP | 1 |
| Arabaci, T | 1 |
| Köse, O | 1 |
| Kizildağ, A | 1 |
| Albayrak, M | 1 |
| Ciçek, Y | 1 |
| Kara, A | 1 |
| Swamikannu, B | 1 |
| Kumar, KS | 1 |
| Jayesh, RS | 1 |
| Rajendran, S | 1 |
| Muthupalani, RS | 1 |
| Ramanathan, A | 2 |
| Vahabi, S | 1 |
| Salman, BN | 1 |
| Rezazadeh, F | 1 |
| Namdari, M | 1 |
| Kumar, R | 1 |
| Singh, RK | 1 |
| Verma, N | 1 |
| Verma, UP | 1 |
| Assaggaf, MA | 1 |
| Kantarci, A | 6 |
| Sume, SS | 3 |
| Trackman, PC | 6 |
| Al-Hamilly, NS | 1 |
| Radwan, LR | 1 |
| Abdul-Rahman, M | 1 |
| Mourad, MI | 1 |
| Grawish, ME | 1 |
| Takeuchi, R | 2 |
| Matsumoto, H | 3 |
| Arikawa, K | 1 |
| Taguchi, C | 1 |
| Nakayama, R | 1 |
| Nasu, I | 1 |
| Hiratsuka, K | 1 |
| Zhang, YH | 1 |
| Sun, QF | 1 |
| Yang, PS | 1 |
| Suzuki, AM | 1 |
| Yoshimura, A | 1 |
| Ozaki, Y | 1 |
| Kaneko, T | 1 |
| Hara, Y | 1 |
| Lee, A | 1 |
| Hasturk, H | 2 |
| Nseir, Z | 1 |
| Kim, YS | 1 |
| Nakib, N | 1 |
| Ashrafi, SS | 1 |
| Arya, R | 1 |
| Gulati, S | 1 |
| Pette, GA | 1 |
| Siegel, MA | 1 |
| Parker, WB | 1 |
| Bondon-Guitton, E | 1 |
| Bagheri, H | 1 |
| Montastruc, JL | 1 |
| Dhingra, K | 1 |
| Prakash, S | 1 |
| Luvizuto, ER | 1 |
| da Silva, JB | 1 |
| Campos, N | 1 |
| Luvizuto, GC | 1 |
| Poi, WR | 1 |
| Panzarini, SR | 1 |
| Akimoto, Y | 2 |
| Fujii, A | 2 |
| Jayaraman, B | 1 |
| Valiathan, GM | 1 |
| Jayakumar, K | 1 |
| Palaniyandi, A | 1 |
| Thenumgal, SJ | 1 |
| Soory, M | 4 |
| Suchak, A | 2 |
| Yamada, H | 1 |
| Nishimura, F | 1 |
| Furuno, K | 1 |
| Naruishi, K | 1 |
| Kobayashi, Y | 1 |
| Takashiba, S | 1 |
| Murayama, Y | 1 |
| Tilakaratne, A | 1 |
| Marakoglu, I | 1 |
| Gursoy, UK | 1 |
| Cakmak, H | 1 |
| Marakoglu, K | 1 |
| Prasad, VN | 1 |
| Chawla, HS | 1 |
| Goyal, A | 1 |
| Gauba, K | 1 |
| Singhi, P | 1 |
| Kato, T | 3 |
| Okahashi, N | 1 |
| Kawai, S | 1 |
| Inaba, H | 1 |
| Morisaki, I | 2 |
| Amano, A | 2 |
| Thomason, JM | 1 |
| Ellis, JS | 1 |
| Jovanovski, V | 1 |
| Corson, M | 1 |
| Lynch, E | 1 |
| Seymour, RA | 3 |
| Studen-Pavlovich, D | 1 |
| Ranalli, DN | 1 |
| Akiyama, S | 1 |
| Takada, Y | 1 |
| Kimura, KR | 1 |
| Namazi, S | 1 |
| Borhani Haghighi, A | 1 |
| Karimzadeh, I | 1 |
| Buduneli, N | 1 |
| Buduneli, E | 1 |
| Cinar, S | 1 |
| Lappin, D | 1 |
| Kinane, DF | 1 |
| Augustin, P | 1 |
| Firatli, E | 2 |
| Sheff, MC | 2 |
| Graves, DT | 1 |
| Garcia, JF | 1 |
| Castro, AL | 1 |
| Crivelini, MM | 1 |
| Tracey, R | 1 |
| Katz, J | 1 |
| Givol, N | 1 |
| Chaushu, G | 1 |
| Taicher, S | 1 |
| Shemer, J | 1 |
| Dill, RE | 1 |
| Iacopino, AM | 1 |
| Kasasa, SC | 1 |
| Sasaki, T | 1 |
| Maita, E | 1 |
| Slezák, R | 1 |
| Desai, P | 1 |
| Silver, JG | 1 |
| Hall, EE | 1 |
| Hassell, TM | 1 |
| Burtner, AP | 1 |
| McNeal, D | 1 |
| Smith, RG | 1 |
| Garzino-Demo, P | 1 |
| Carbone, M | 1 |
| Carrozzo, M | 1 |
| Broccoletti, R | 1 |
| Gandolfo, S | 1 |
| Kamali, F | 2 |
| Ball, DE | 2 |
| McLaughlin, WS | 2 |
| Morton, RS | 1 |
| Dongari-Bagtzoglou, AI | 1 |
| Marshall, RI | 1 |
| Hernández, G | 1 |
| Arriba, L | 1 |
| Lucas, M | 1 |
| de Andrés, A | 1 |
| Uzel, MI | 1 |
| Hong, HH | 1 |
| Uygur, C | 1 |
| Doğan, A | 1 |
| Tunca, Y | 1 |
| Ozdemir, A | 1 |
| Sengül, A | 1 |
| Imirzalioğlu, N | 1 |
| Noji, I | 1 |
12 reviews available for phenytoin and Gingival Overgrowth
| Article | Year |
|---|---|
Bibliometric analysis of research trends and characteristics of drug-induced gingival overgrowth.
Topics: Amlodipine; Anticonvulsants; Bibliometrics; Calcium Channel Blockers; Cyclosporine; Gingival Overgro | 2022 |
Periodontal complications of prescription and recreational drugs.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Calcium Channel | 2018 |
Drug-induced gingival overgrowth.
Topics: Adult; Anticonvulsants; Calcium Channel Blockers; Child; Cyclosporine; Gingiva; Gingival Overgrowth; | 2011 |
Phenytoin-induced gingival overgrowth.
Topics: Anticonvulsants; Gingiva; Gingival Overgrowth; Humans; Phenytoin | 2012 |
Connective tissue metabolism and gingival overgrowth.
Topics: Animals; Anticonvulsants; Antihypertensive Agents; Connective Tissue; Connective Tissue Growth Facto | 2004 |
Drug-induced gingival overgrowth after phenytoin and nifedipine therapy. A case report.
Topics: Anticonvulsants; Calcium Channel Blockers; Drug Therapy, Combination; Female; Gingival Overgrowth; H | 1997 |
Drug-induced gingival enlargements.
Topics: Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Gingival Overgrowth; Humans; Immunosuppress | 1998 |
Prevention and treatment considerations in patients with drug-induced gingival enlargement.
Topics: Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Dental Prophylaxis; Gingival Overgrowth; Gi | 1997 |
Oral problems and genetic aspects of individuals with epilepsy.
Topics: Dental Care for Chronically Ill; Dental Plaque; Dental Prophylaxis; Epilepsy; Fibroblasts; Gingival | 1994 |
[An increase in gingival volume induced by drugs (phenytoin, cyclosporine and calcium antagonists). A review of the literature].
Topics: Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Gingival Overgrowth; Humans; Immunosuppress | 1998 |
A clinical review of drug-induced gingival overgrowths.
Topics: Anticonvulsants; Australia; Calcium Channel Blockers; Cyclosporine; Drug Interactions; Gingival Over | 1999 |
Reduction of severe gingival overgrowth in a kidney transplant patient by replacing cyclosporin A with tacrolimus.
Topics: Anticonvulsants; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Epilepsy; Female; Gingival | 2000 |
1 trial available for phenytoin and Gingival Overgrowth
| Article | Year |
|---|---|
Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect.
Topics: Adolescent; Anticonvulsants; Child; Dental Plaque; Epilepsy; Folic Acid; Follow-Up Studies; Gingival | 2004 |
51 other studies available for phenytoin and Gingival Overgrowth
| Article | Year |
|---|---|
Phenytoin induces connective tissue growth factor (CTGF/CCN2) production through NADPH oxidase 4-mediated latent TGFβ1 activation in human gingiva fibroblasts: Suppression by curcumin.
Topics: Cells, Cultured; Connective Tissue Growth Factor; Curcumin; Fibroblasts; Fibrosis; Gingiva; Gingival | 2022 |
Phenytoin-induced gingival overgrowth.
Topics: Anticonvulsants; Gingival Overgrowth; Humans; Phenytoin | 2022 |
Role of Epithelial Mesenchymal Transition in Phenytoin Influenced Gingival Overgrowth in Children and Young Adults. A Preliminary Clinical and Immunohistochemical Study.
Topics: Child; Epithelial-Mesenchymal Transition; Gingiva; Gingival Overgrowth; Humans; Male; Membrane Prote | 2019 |
Curcumin Effect on the Prevention of Gingival Overgrowth Following Phenytoin Consumption in Rats: A Clinicohistological and Immunohistochemical Study.
Topics: Animals; Curcumin; Gingiva; Gingival Overgrowth; Male; Phenytoin; Rats; Rats, Wistar | 2019 |
Drug-Induced Gingival Overgrowth: A Pilot Study on the Effect of Diphenylhydantoin and Gabapentin on Human Gingival Fibroblasts.
Topics: Aged; Anticonvulsants; Child; Female; Fibroblasts; Gabapentin; Gene Expression; Gingiva; Gingival Hy | 2020 |
Gingival overgrowth induced by anticonvulsant drugs: A cross-sectional study on epileptic patients.
Topics: Anticonvulsants; Cross-Sectional Studies; Epilepsy; Female; Gingival Overgrowth; Humans; Male; Pheny | 2021 |
Lack of pathogenic mutations in SOS1 gene in phenytoin-induced gingival overgrowth patients.
Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Chromatography, High Pressure Liquid; Epil | 2017 |
TRPA1 Channels Mediate Human Gingival Fibroblast Response to Phenytoin.
Topics: Acetanilides; Animals; Anticonvulsants; Antioxidants; Blotting, Western; Calcium Channels; Cell Line | 2017 |
Phenytoin activates Smad3 phosphorylation and periostin expression in drug-induced gingival enlargement.
Topics: Adult; Aged; Anticonvulsants; Cell Adhesion Molecules; Female; Fibroblasts; Gingival Overgrowth; Hum | 2018 |
Effects of cyclosporin, nifedipine and phenytoin on gingival myofibroblast transdifferentiation in monkeys.
Topics: Actins; Animals; Apoptosis; Biopsy; Cell Proliferation; Cell Transdifferentiation; Cyclosporine; Gen | 2018 |
Role of nuclear factor kappa-B in phenytoin-induced gingival overgrowth.
Topics: Adolescent; Adult; Anticonvulsants; Female; Gingival Overgrowth; Gingivitis; Humans; Male; NF-kappa | 2014 |
Comprehensive mutation analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 genes is suggestive of a non- neoplastic nature of phenytoin induced gingival overgrowth.
Topics: Base Sequence; Carcinoma, Squamous Cell; Class I Phosphatidylinositol 3-Kinases; Cross-Sectional Stu | 2013 |
Effects of cyclosporine and phenytoin on biomarker expressions in gingival fibroblasts of children and adults: an in vitro study.
Topics: Adult; Age Factors; Biomarkers; Cell Culture Techniques; Cells, Cultured; Child; Cyclosporine; Enzym | 2014 |
Phenytoin-induced severe gingival overgrowth in a child.
Topics: Anticonvulsants; Child; Diagnosis, Differential; Epilepsy; Gingival Overgrowth; Humans; Male; Oral H | 2014 |
Prevention of phenytoin-induced gingival overgrowth by lovastatin in mice.
Topics: Amino Acid Oxidoreductases; Animals; Cadherins; Connective Tissue Growth Factor; Gingiva; Gingival O | 2015 |
Biological roles of KGF, CTGF and TGF-β in cyclosporine-A- and phenytoin- induced gingival overgrowth: A comparative experimental animal study.
Topics: Animals; Connective Tissue Growth Factor; Cyclosporine; Disease Models, Animal; Epithelium; Fibrobla | 2016 |
Phenytoin-induced gingival overgrowth caused by death receptor pathway malfunction.
Topics: Anticonvulsants; Apoptosis; Baculoviral IAP Repeat-Containing 3 Protein; CASP8 and FADD-Like Apoptos | 2017 |
[Research advances in the mechanism of phenytoin-induced gingival overgrowth].
Topics: Anticonvulsants; Fibroblasts; Gingiva; Gingival Overgrowth; Humans; Phenytoin | 2009 |
Cyclosporin A and phenytoin modulate inflammatory responses.
Topics: Animals; Anticonvulsants; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Cyclosporine; Down-Reg | 2009 |
Epithelial to mesenchymal transition in gingival overgrowth.
Topics: Animals; Anticonvulsants; Antigens, Neoplasm; Cadherins; Calcium-Binding Proteins; Cells, Cultured; | 2010 |
Loss of basement membrane integrity in human gingival overgrowth.
Topics: Adult; Analysis of Variance; Basement Membrane; Case-Control Studies; Cell Adhesion Molecules; Colla | 2011 |
Gingival enlargement.
Topics: Adult; Anticonvulsants; Collagen; Dental Scaling; Female; Gingival Overgrowth; Gingivectomy; Guided | 2011 |
Drug-induced gingival overgrowth: a study in the French Pharmacovigilance Database.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Calcium Channel Blockers; Child; Child, Preschool; Cyclosp | 2012 |
Gingival overgrowth in partially edentulous ridges in an elderly female patient with epilepsy: a case report.
Topics: Anticonvulsants; Denture, Complete; Epilepsy, Tonic-Clonic; Female; Follow-Up Studies; Gingiva; Ging | 2012 |
Functional aesthetic treatment of patient with phenytoin-induced gingival overgrowth.
Topics: Adult; Anticonvulsants; Dental Prophylaxis; Dental Scaling; Gingival Overgrowth; Gingivectomy; Human | 2012 |
Inhibition of G₁ cell cycle arrest in human gingival fibroblasts exposed to phenytoin.
Topics: Cell Proliferation; Cells, Cultured; Fibroblasts; G1 Phase Cell Cycle Checkpoints; Gingiva; Gingival | 2014 |
Lack of mutation in p53 and H-ras genes in phenytoin induced gingival overgrowth suggests its non cancerous nature.
Topics: Adolescent; Adult; Anticonvulsants; Cross-Sectional Studies; DNA Primers; DNA, Neoplasm; Exons; Fema | 2012 |
Phenytoin-mediated androgen metabolism in gingival fibroblasts. Effects of the antiandrogen finasteride and the alkaline phosphatase inhibitor levamisole.
Topics: 5-alpha Reductase Inhibitors; Adult; Alkaline Phosphatase; Androgen Antagonists; Androgens; Androste | 2002 |
Serum phenytoin concentration and IgG antibody titre to periodontal bacteria in patients with phenytoin-induced gingival overgrowth.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aggregatibacter actinomycetemcomitans; Antibodies, Ba | 2001 |
Modulation of androgen metabolism by phenytoin, oestradiol and tamoxifen in human gingival fibroblasts.
Topics: Adult; Androstenedione; Anticonvulsants; Cells, Cultured; Dihydrotestosterone; Estradiol; Estrogen A | 2003 |
Phenytoin-induced gingival overgrowth in un-cooperated epilepsy patients.
Topics: Adult; Anticonvulsants; Epilepsy; Gingival Overgrowth; Humans; Male; Oral Hygiene; Patient Complianc | 2004 |
Impaired degradation of matrix collagen in human gingival fibroblasts by the antiepileptic drug phenytoin.
Topics: Anticonvulsants; Cell Proliferation; Collagen; Endocytosis; Fibroblasts; Gingiva; Gingival Overgrowt | 2005 |
Analysis of changes in gingival contour from three-dimensional co-ordinate data in subjects with drug-induced gingival overgrowth.
Topics: Gingiva; Gingival Overgrowth; Gingivectomy; Humans; Image Processing, Computer-Assisted; Models, Den | 2005 |
Periodontal and soft tissue prevention strategies for the adolescent dental patient.
Topics: Adolescent; Amphetamines; Anticonvulsants; Central Nervous System Stimulants; Chronic Disease; Cyclo | 2006 |
Relationship of periodontal bacteria and Porphyromonas gingivalis fimA variations with phenytoin-induced gingival overgrowth.
Topics: Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Anticonvulsants; Bacteroides; Child; Denta | 2006 |
Is oral azithromycin effective for the treatment of phenytoin-induced gingival overgrowth in epileptic patients?
Topics: Administration, Oral; Anti-Bacterial Agents; Anticonvulsants; Azithromycin; Drug Interactions; Epile | 2007 |
Immunohistochemical evaluation of Ki-67 expression and apoptosis in cyclosporin A-induced gingival overgrowth.
Topics: Adult; Analysis of Variance; Apoptosis; Calcium Channel Blockers; Case-Control Studies; Cell Prolife | 2007 |
Apoptosis in gingival overgrowth tissues.
Topics: Anticonvulsants; Apoptosis; Calcium Channel Blockers; Case-Control Studies; Caspase 3; Cell Prolifer | 2007 |
Effects of cyclosporin, phenytoin, and nifedipine on the synthesis and degradation of gingival collagen in tufted capuchin monkeys (Cebus apella): histochemical and MMP-1 and -2 and collagen I gene expression analyses.
Topics: Animals; Anticonvulsants; Azo Compounds; Biopsy; Calcium Channel Blockers; Cebus; Collagen; Collagen | 2008 |
Soft-tissue surgery: use of the Er,Cr:YSGG laser.
Topics: Adolescent; Anticonvulsants; Child; Female; Fibroma; Follow-Up Studies; Gingival Overgrowth; Gingive | 2008 |
Vigabatrin-induced gingival overgrowth.
Topics: Adult; Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Epilepsy, Complex Partial; Female; F | 1997 |
Myofibroblasts in phenytoin-induced hyperplastic connective tissue in the rat and in human gingival overgrowth.
Topics: Actin Cytoskeleton; Adult; Animals; Anticonvulsants; Cell Count; Cell Division; Cell Size; Connectiv | 1997 |
The effects of epidermal growth factor, interleukin-1, and phenytoin, alone and in combination, on C19 steroid conversions in fibroblasts.
Topics: 17-Hydroxysteroid Dehydrogenases; Androstenedione; Bone and Bones; Carbon Radioisotopes; Cells, Cult | 1997 |
Increased bFGF level in the serum of patients with phenytoin-induced gingival overgrowth.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Chromatography, High Pressure Liquid; Enzyme | 1998 |
Phenytoin metabolism to 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) in man, cat and rat in vitro and in vivo, and susceptibility to phenytoin-induced gingival overgrowth.
Topics: Adult; Aged; Animals; Anticonvulsants; Area Under Curve; Biotransformation; Cats; Chlorophyll; Chrom | 1999 |
The effect of multiple anticonvulsant therapy on the expression of phenytoin-induced gingival overgrowth.
Topics: Adult; Anticonvulsants; Chromatography, High Pressure Liquid; Drug Interactions; Drug Therapy, Combi | 1999 |
Regulation of gingival fibroblast interleukin-6 secretion by cyclosporine A.
Topics: Anticonvulsants; Bacteria; Calcium Channel Blockers; Cell Division; Cells, Cultured; Cyclosporine; D | 1999 |
The effects of human mast-cell products and of phenytoin on androgen 5alpha-reductase expression in human gingival fibroblasts.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Androstenedione; Anticonvulsants; Cells, Cultured; Cul | 2001 |
Connective tissue growth factor in drug-induced gingival overgrowth.
Topics: Adult; Antibodies; Anticonvulsants; Calcium Channel Blockers; Carrier Proteins; Coloring Agents; Con | 2001 |
The effects of folic acid application on IL-1beta levels of human gingival fibroblasts stimulated by phenytoin and TNFalpha in vitro: a preliminary study.
Topics: Anticonvulsants; Cell Culture Techniques; Culture Media; Enzyme-Linked Immunosorbent Assay; Fibrobla | 2001 |
Comparative study of calcium-channel blockers on cell proliferation, DNA and collagen syntheses, and EGF receptors of cultured gingival fibroblasts derived from human nifedipine, nicardipine and nisoldipine responders.
Topics: Adult; Aged; Analysis of Variance; Anticonvulsants; Calcium Channel Blockers; Cell Culture Technique | 2001 |