phenytoin has been researched along with Genetic Predisposition in 21 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are fatal adverse cutaneous drug reactions which may be induced by phenytoin (PHT) or lamotrigine (LTG)." | 8.91 | HLA-B*1502 increases the risk of phenytoin or lamotrigine induced Stevens-Johnson Syndrome/toxic epidermal necrolysis: evidence from a meta-analysis of nine case-control studies. ( Huo, J; Li, X; Mei, S; Wang, J; Yu, K; Zhao, Z; Zhu, Y, 2015) |
| "Valproic acid, which is widely used to treat various types of epilepsy, may cause severe hyperammonemia." | 7.80 | 4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. ( Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Miyakawa, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R, 2014) |
| "Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) in Han Chinese, but not in Caucasian populations." | 7.74 | Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. ( Desudchit, T; Hirankarn, N; Kangwanshiratada, O; Korkij, W; Limotai, C; Locharernkul, C; Loplumlert, J; Shotelersuk, V; Suphapeetiporn, K; Tongkobpetch, S, 2008) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are fatal adverse cutaneous drug reactions which may be induced by phenytoin (PHT) or lamotrigine (LTG)." | 4.91 | HLA-B*1502 increases the risk of phenytoin or lamotrigine induced Stevens-Johnson Syndrome/toxic epidermal necrolysis: evidence from a meta-analysis of nine case-control studies. ( Huo, J; Li, X; Mei, S; Wang, J; Yu, K; Zhao, Z; Zhu, Y, 2015) |
| "Phenytoin (PHT) is a common cause of severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS)." | 3.85 | Association of HLA-B*15:13 and HLA-B*15:02 with phenytoin-induced severe cutaneous adverse reactions in a Malay population. ( Chang, CC; Choon, SE; Chung, WH; Hussein, SH; Lee, CK; Lim, KS; Murad, S; Ng, CC; Too, CL, 2017) |
| "Phenytoin is one of the most common causative drugs of several types of severe cutaneous adverse reactions (SCAR) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms (DRESS)." | 3.83 | Associations between HLA class I and cytochrome P450 2C9 genetic polymorphisms and phenytoin-related severe cutaneous adverse reactions in a Thai population. ( Chumworathayi, P; Khunarkornsiri, U; Kongpan, T; Konyoung, P; Kulkantrakorn, K; Mahasirimongkol, S; Nakkam, N; Prabmeechai, N; Rerkpattanapipat, T; Saksit, N; Sangviroon, A; Satapornpong, P; Sukasem, C; Tassaneeyakul, W; Tiamkao, S; Vannaprasaht, S; Wichukchinda, N, 2016) |
| "Valproic acid, which is widely used to treat various types of epilepsy, may cause severe hyperammonemia." | 3.80 | 4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. ( Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Miyakawa, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R, 2014) |
| "Asians who carry the HLA-B*1502 allele have an elevated risk of developing Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) when treated with the antiepileptic drugs (AEDs) carbamazepine (CBZ) and phenytoin (PHT)." | 3.78 | Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore. ( Dong, D; Finkelstein, EA; Sung, C, 2012) |
| "Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) in Han Chinese, but not in Caucasian populations." | 3.74 | Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. ( Desudchit, T; Hirankarn, N; Kangwanshiratada, O; Korkij, W; Limotai, C; Locharernkul, C; Loplumlert, J; Shotelersuk, V; Suphapeetiporn, K; Tongkobpetch, S, 2008) |
| "A previous study conducted in Taiwan found a 100% association between HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine-tolerant subjects (odds ratio = 2,504)." | 3.74 | Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese. ( Baum, L; Cheng, AS; Kwan, P; Lau, KM; Man, CB; Ng, MH; Yu, E, 2007) |
| "We have chosen to study the role of genetic susceptibility to teratogen-induced orofacial clefting, using 2 drugs (dilantin and corticosteroid) and 1 nondrug teratogen (6-aminonicotinamide)." | 2.46 | Genes, environment, and orofacial clefting: N-acetyltransferase and folic acid. ( Erickson, RP, 2010) |
| " In this model in Wistar rats, animals which do not respond to repeated or chronic administration of anti-epileptic drugs (non-responders) can be separated from animals in whom anti-epileptics are effective (responders)." | 2.41 | Animal models of drug-resistant epilepsy. ( Löscher, W, 2002) |
| "Phenytoin (PHT) is a common causative drug for severe cutaneous adverse drug reactions (SCARs) in children." | 1.56 | Association of HLA genotypes with phenytoin induced severe cutaneous adverse drug reactions in Thai children. ( Benjaponpitak, S; Inunchot, W; Kamchaisatian, W; Khongkhatithuml, C; Likkasittipan, P; Mahasirimongkol, S; Manuyakorn, W; Suvichapanich, S; Thampratankul, L; Wattanapokayakit, S; Wichukchinda, N, 2020) |
| "Phenytoin drug reaction with eosinophilia and systemic symptoms (DRESS) in 3 Aboriginal Australians positive for HLA-B*56:02 has been previously reported." | 1.51 | High and variable population prevalence of HLA-B*56:02 in indigenous Australians and relation to phenytoin-associated drug reaction with eosinophilia and systemic symptoms. ( Barratt, DT; Gabb, GM; Ilyas, F; Moore, K; Phillips, EJ; Somogyi, AA, 2019) |
| " We identified significant associations of CYP2C9 variant alleles with presence of phenytoin (PHT) adverse drug reactions (ADRs) and of GSTM1 copy number variation with the presence of carbamazepine ADRs." | 1.37 | A candidate gene study of antiepileptic drug tolerability and efficacy identifies an association of CYP2C9 variants with phenytoin toxicity. ( Da Cruz, AL; Depondt, C; Espel, RS; Godard, P; Lienard, P; Pandolfo, M, 2011) |
| "That increased I(Nap) may contribute to seizure-like activity is indicated by the observation that feeding sda larvae the antiepileptic drug phenytoin, which was sufficient to reduce I(Nap), rescued both seizure-like episode duration and synaptic excitation of motoneurons." | 1.37 | Increased persistent Na+ current contributes to seizure in the slamdance bang-sensitive Drosophila mutant. ( Baines, RA; Marley, R, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 12 (57.14) | 24.3611 |
| 2020's | 3 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Sukasem, C | 2 |
| Sririttha, S | 1 |
| Tempark, T | 1 |
| Klaewsongkram, J | 1 |
| Rerkpattanapipat, T | 2 |
| Puangpetch, A | 1 |
| Boongird, A | 1 |
| Chulavatnatol, S | 1 |
| Fohner, AE | 1 |
| Rettie, AE | 1 |
| Thai, KK | 1 |
| Ranatunga, DK | 1 |
| Lawson, BL | 1 |
| Liu, VX | 1 |
| Schaefer, CA | 1 |
| Manuyakorn, W | 2 |
| Likkasittipan, P | 1 |
| Wattanapokayakit, S | 1 |
| Suvichapanich, S | 2 |
| Inunchot, W | 1 |
| Wichukchinda, N | 3 |
| Khongkhatithuml, C | 1 |
| Thampratankul, L | 1 |
| Kamchaisatian, W | 2 |
| Benjaponpitak, S | 1 |
| Mahasirimongkol, S | 3 |
| Manoharan, A | 1 |
| Kumar, AS | 1 |
| Sreedevi, A | 1 |
| Sathishkannan, AD | 1 |
| Gaddam, BK | 1 |
| Somogyi, AA | 1 |
| Barratt, DT | 1 |
| Phillips, EJ | 1 |
| Moore, K | 1 |
| Ilyas, F | 1 |
| Gabb, GM | 1 |
| Paprocka, J | 1 |
| Jezela-Stanek, A | 1 |
| Koppolu, A | 1 |
| Rydzanicz, M | 1 |
| Kosińska, J | 1 |
| Stawiński, P | 1 |
| Płoski, R | 1 |
| Li, X | 1 |
| Yu, K | 1 |
| Mei, S | 1 |
| Huo, J | 1 |
| Wang, J | 1 |
| Zhu, Y | 1 |
| Zhao, Z | 1 |
| Inoue, K | 1 |
| Suzuki, E | 1 |
| Takahashi, T | 1 |
| Yamamoto, Y | 1 |
| Yazawa, R | 1 |
| Takahashi, Y | 1 |
| Imai, K | 1 |
| Miyakawa, K | 1 |
| Inoue, Y | 1 |
| Tsuji, D | 1 |
| Hayashi, H | 1 |
| Itoh, K | 1 |
| Jittikoon, J | 1 |
| Visudtibhan, A | 1 |
| Benjapopitak, S | 1 |
| Nakornchai, S | 1 |
| Chang, CC | 1 |
| Ng, CC | 1 |
| Too, CL | 1 |
| Choon, SE | 1 |
| Lee, CK | 1 |
| Chung, WH | 1 |
| Hussein, SH | 1 |
| Lim, KS | 1 |
| Murad, S | 1 |
| Tassaneeyakul, W | 2 |
| Prabmeechai, N | 1 |
| Kongpan, T | 1 |
| Konyoung, P | 1 |
| Chumworathayi, P | 1 |
| Tiamkao, S | 1 |
| Khunarkornsiri, U | 1 |
| Kulkantrakorn, K | 1 |
| Saksit, N | 1 |
| Nakkam, N | 1 |
| Satapornpong, P | 1 |
| Vannaprasaht, S | 1 |
| Sangviroon, A | 1 |
| Locharernkul, C | 1 |
| Loplumlert, J | 1 |
| Limotai, C | 1 |
| Korkij, W | 1 |
| Desudchit, T | 1 |
| Tongkobpetch, S | 1 |
| Kangwanshiratada, O | 1 |
| Hirankarn, N | 1 |
| Suphapeetiporn, K | 1 |
| Shotelersuk, V | 1 |
| Erickson, RP | 1 |
| Depondt, C | 1 |
| Godard, P | 1 |
| Espel, RS | 1 |
| Da Cruz, AL | 1 |
| Lienard, P | 1 |
| Pandolfo, M | 1 |
| Marley, R | 1 |
| Baines, RA | 1 |
| Dong, D | 1 |
| Sung, C | 1 |
| Finkelstein, EA | 1 |
| Citerio, G | 1 |
| Nobili, A | 1 |
| Airoldi, L | 1 |
| Pastorelli, R | 1 |
| Patruno, A | 1 |
| Soga, Y | 1 |
| Nishimura, F | 1 |
| Ohtsuka, Y | 1 |
| Araki, H | 1 |
| Iwamoto, Y | 1 |
| Naruishi, H | 1 |
| Shiomi, N | 1 |
| Kobayashi, Y | 1 |
| Takashiba, S | 1 |
| Shimizu, K | 1 |
| Gomita, Y | 1 |
| Oka, E | 1 |
| Soranzo, N | 1 |
| Kelly, L | 1 |
| Martinian, L | 1 |
| Burley, MW | 1 |
| Thom, M | 1 |
| Sali, A | 1 |
| Kroetz, DL | 1 |
| Goldstein, DB | 1 |
| Sisodiya, SM | 1 |
| Man, CB | 1 |
| Kwan, P | 1 |
| Baum, L | 1 |
| Yu, E | 1 |
| Lau, KM | 1 |
| Cheng, AS | 1 |
| Ng, MH | 1 |
| Löscher, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency[NCT01379469] | Phase 2 | 20 participants (Actual) | Interventional | 2012-01-31 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for phenytoin and Genetic Predisposition
| Article | Year |
|---|---|
HLA-B*1502 increases the risk of phenytoin or lamotrigine induced Stevens-Johnson Syndrome/toxic epidermal necrolysis: evidence from a meta-analysis of nine case-control studies.
Topics: Anticonvulsants; Case-Control Studies; Epilepsy; Genetic Predisposition to Disease; HLA-B15 Antigen; | 2015 |
Genes, environment, and orofacial clefting: N-acetyltransferase and folic acid.
Topics: 6-Aminonicotinamide; Animals; Arylamine N-Acetyltransferase; Cleft Lip; Cleft Palate; Disease Models | 2010 |
Animal models of drug-resistant epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; | 2002 |
18 other studies available for phenytoin and Genetic Predisposition
| Article | Year |
|---|---|
Genetic and clinical risk factors associated with phenytoin-induced cutaneous adverse drug reactions in Thai population.
Topics: Anticonvulsants; Case-Control Studies; Female; Genetic Predisposition to Disease; Humans; Male; Midd | 2020 |
Associations of CYP2C9 and CYP2C19 Pharmacogenetic Variation with Phenytoin-Induced Cutaneous Adverse Drug Reactions.
Topics: Aged; Aged, 80 and over; Alleles; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Eruptions; | 2020 |
Association of HLA genotypes with phenytoin induced severe cutaneous adverse drug reactions in Thai children.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Hypersensitivity Syndrome; Female; Geneti | 2020 |
HLA-B*5701 and HLA-B*5801 in an Indian patient with anti-epileptics induced cutaneous adverse drug reactions.
Topics: Acute Generalized Exanthematous Pustulosis; Alleles; Anticonvulsants; Carbamazepine; Epilepsy; Genet | 2019 |
High and variable population prevalence of HLA-B*56:02 in indigenous Australians and relation to phenytoin-associated drug reaction with eosinophilia and systemic symptoms.
Topics: Adolescent; Adult; Aged; Australia; Biological Variation, Population; Cohort Studies; Cytochrome P-4 | 2019 |
FGF12p.Gly112Ser variant as a cause of phenytoin/phenobarbital responsive epilepsy.
Topics: Alleles; Amino Acid Substitution; Anticonvulsants; Child, Preschool; Electroencephalography; Epileps | 2019 |
4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy.
Topics: Alleles; Amino-Acid N-Acetyltransferase; Ammonia; Anticonvulsants; Asian People; Biomarkers, Pharmac | 2014 |
Association analysis of CYP2C9*3 and phenytoin-induced severe cutaneous adverse reactions (SCARs) in Thai epilepsy children.
Topics: Anticonvulsants; Child; Child, Preschool; Cytochrome P-450 CYP2C9; Drug Eruptions; Epilepsy; Female; | 2015 |
Association of HLA-B*15:13 and HLA-B*15:02 with phenytoin-induced severe cutaneous adverse reactions in a Malay population.
Topics: Anticonvulsants; Case-Control Studies; Drug Hypersensitivity Syndrome; Female; Gene Frequency; Genet | 2017 |
Associations between HLA class I and cytochrome P450 2C9 genetic polymorphisms and phenytoin-related severe cutaneous adverse reactions in a Thai population.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asian People; Cytochrome P-450 CYP2C9; Female; Genetic A | 2016 |
Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Genetic Predisposition t | 2008 |
A candidate gene study of antiepileptic drug tolerability and efficacy identifies an association of CYP2C9 variants with phenytoin toxicity.
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Epilepsy; Female; Genetic A | 2011 |
Increased persistent Na+ current contributes to seizure in the slamdance bang-sensitive Drosophila mutant.
Topics: Action Potentials; Animals; Anticonvulsants; Calcium Channels; Cnidarian Venoms; Disease Models, Ani | 2011 |
Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore.
Topics: Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Cost-Benefit Analysis; Decision Making | 2012 |
Severe intoxication after phenytoin infusion: a preventable pharmacogenetic adverse reaction.
Topics: Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Brain Neoplasms; Chemical and Drug Induced Li | 2003 |
CYP2C polymorphisms, phenytoin metabolism and gingival overgrowth in epileptic subjects.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; C | 2004 |
Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy.
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Trans | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |