phenytoin has been researched along with Fetal Resorption in 18 studies
Fetal Resorption: The disintegration and assimilation of the dead FETUS in the UTERUS at any stage after the completion of organogenesis which, in humans, is after the 9th week of GESTATION. It does not include embryo resorption (see EMBRYO LOSS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The toxic interaction of caffeine and phenytoin during pregnancy was investigated in mice of the ICR strain on E10 of gestation." | 7.67 | The toxicology of chemical interactions during pregnancy in the mouse: caffeine and phenytoin. ( Kwasigroch, TE; Poche, PD; Skalko, RG, 1984) |
| "Pregnant female mice of various congenic strains were injected on days 11 through 14 of gestation with phenytoin, and the fetuses were examined for the occurrence of cleft palate." | 7.66 | Susceptibility to phenytoin-induced cleft palate in mice is influenced by genes linked to H-2 and H-3. ( Baker, MK; Gasser, DL; Goldman, AS, 1983) |
| "The toxic interaction of caffeine and phenytoin during pregnancy was investigated in mice of the ICR strain on E10 of gestation." | 3.67 | The toxicology of chemical interactions during pregnancy in the mouse: caffeine and phenytoin. ( Kwasigroch, TE; Poche, PD; Skalko, RG, 1984) |
| "Pregnant female mice of various congenic strains were injected on days 11 through 14 of gestation with phenytoin, and the fetuses were examined for the occurrence of cleft palate." | 3.66 | Susceptibility to phenytoin-induced cleft palate in mice is influenced by genes linked to H-2 and H-3. ( Baker, MK; Gasser, DL; Goldman, AS, 1983) |
| " Previous work had demonstrated that PHT treatment significantly increased endogenous maternal corticosterone concentrations for approximately 48 hr after dosing in A/J mice." | 1.28 | Embryotoxicity of phenytoin in adrenalectomized CD-1 mice. ( Branham, WS; Hansen, DK; Holson, RR; Sheehan, DM, 1992) |
| " Pharmacokinetic sampling in oral and i." | 1.28 | Developmental toxicity and pharmacokinetics of oral and intravenous phenytoin in the rat. ( Binkerd, PE; Hendrickx, AG; Rowland, JR, 1990) |
| "Phenytoin, 55 mg/kg, was administered intraperitoneally (ip) to pregnant CD-1 mice at 0900 hr on gestational days 12 and 13." | 1.28 | Enhancement of murine phenytoin teratogenicity by the gamma-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine and by the glutathione depletor diethyl maleate. ( Helston, LM; Wells, PG; Wong, M, 1989) |
| "Phenytoin is a drug of considerable medical use, but very little is known about the various possible intermediate steps involved in its action." | 1.26 | Phenytoin administration to pregnant mice: a mutagenic action? ( Ehrensperger, M; Lombard, MN; Petter, C, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (83.33) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hansen, DK | 3 |
| Hodes, ME | 1 |
| Wells, PG | 5 |
| Skalko, RG | 1 |
| Poche, PD | 1 |
| Kwasigroch, TE | 1 |
| Goldman, AS | 1 |
| Baker, MK | 1 |
| Gasser, DL | 1 |
| McDevitt, JM | 1 |
| Gautieri, RF | 1 |
| Mann, DE | 1 |
| Petter, C | 1 |
| Lombard, MN | 1 |
| Ehrensperger, M | 1 |
| Witkowski, CE | 1 |
| Sucheston, ME | 1 |
| Netzloff, ML | 1 |
| Streiff, RR | 1 |
| Frias, JL | 1 |
| Rennert, OM | 1 |
| Branham, WS | 1 |
| Sheehan, DM | 1 |
| Holson, RR | 1 |
| Collins, MD | 1 |
| Fradkin, R | 1 |
| Scott, WJ | 1 |
| Rowland, JR | 1 |
| Binkerd, PE | 1 |
| Hendrickx, AG | 1 |
| Zubovits, JT | 1 |
| Wong, ST | 1 |
| Molinari, LM | 1 |
| Ali, S | 1 |
| Finnell, RH | 1 |
| Abbott, LC | 1 |
| Taylor, SM | 1 |
| Vo, HP | 1 |
| Wong, M | 2 |
| Helston, LM | 1 |
| Barcellona, PS | 1 |
| Barale, R | 1 |
| Campana, A | 1 |
| Zucconi, D | 1 |
| Rossi, V | 1 |
| Caranti, S | 1 |
| Billings, RE | 1 |
18 other studies available for phenytoin and Fetal Resorption
| Article | Year |
|---|---|
Comparative teratogenicity of phenytoin among several inbred strains of mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Dose-Response Relationship, Drug; Fem | 1983 |
Physiological and environmental determinants of phenytoin teratogenicity: relation to glutathione homeostasis, and potentiation by acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Cleft Palate; Drug Synergism; Female; Fetal Resorption; Glut | 1983 |
The toxicology of chemical interactions during pregnancy in the mouse: caffeine and phenytoin.
Topics: Animals; Caffeine; Drug Interactions; Female; Fetal Death; Fetal Resorption; Mice; Mice, Inbred ICR; | 1984 |
Susceptibility to phenytoin-induced cleft palate in mice is influenced by genes linked to H-2 and H-3.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fetal Resorption; Genotype; H-2 Antigens | 1983 |
Comparative teratogenicity of cortisone and phenytoin in mice.
Topics: Animals; Body Weight; Cleft Palate; Cortisone; Dose-Response Relationship, Drug; Female; Fetal Resor | 1981 |
Phenytoin administration to pregnant mice: a mutagenic action?
Topics: Abnormalities, Drug-Induced; Animals; Female; Fertility; Fetal Resorption; Mice; Mutagens; Phenytoin | 1981 |
Teratological effects of diphenylhydantoin (DPH) in A/J mice.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Resorption; Mice; Mice, Inbred Strains; Phenytoi | 1979 |
Folate antagonism following teratogenic exposure to diphenylhydantoin.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Resorption; Fetus; Folic Acid Antagonists; Folic | 1979 |
Embryotoxicity of phenytoin in adrenalectomized CD-1 mice.
Topics: Abnormalities, Drug-Induced; Adrenalectomy; Animals; Cleft Palate; Corticosterone; Female; Fetal Res | 1992 |
Induction of postaxial forelimb ectrodactyly with anticonvulsant agents in A/J mice.
Topics: Abnormalities, Drug-Induced; Animals; Birth Weight; Dimethadione; Female; Fetal Death; Fetal Resorpt | 1990 |
Developmental toxicity and pharmacokinetics of oral and intravenous phenytoin in the rat.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Body Weight; Female; Fetal Resorption; H | 1990 |
Modulation of phenytoin teratogenicity and embryonic covalent binding by acetylsalicylic acid, caffeic acid, and alpha-phenyl-N-t-butylnitrone: implications for bioactivation by prostaglandin synthetase.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Biotransformation; Caffeic Acids; Cinnamates; Cyclic | 1989 |
The fetal hydantoin syndrome: answers from a mouse model.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Disease Models, Animal; Embryo Implantation; Fema | 1989 |
Effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on phenytoin-induced embryopathy in mice.
Topics: Animals; Dose-Response Relationship, Drug; Female; Fetal Death; Fetal Resorption; Fetus; Mice; Pheny | 1989 |
Modulation of embryonic glutathione reductase and phenytoin teratogenicity by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
Topics: Animals; Carmustine; Cleft Palate; Drug Interactions; Embryo, Mammalian; Female; Fetal Resorption; G | 1989 |
Enhancement of murine phenytoin teratogenicity by the gamma-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine and by the glutathione depletor diethyl maleate.
Topics: Administration, Oral; Analysis of Variance; Animals; Body Weight; Buthionine Sulfoximine; Cleft Pala | 1989 |
Correlations between embryotoxic and genotoxic effects of phenytoin in mice.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Cell Nucleus; Cytochrome P-450 CYP1A2; Cyto | 1987 |
Effect of route of administration on phenytoin teratogenicity in A/J mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Diet; Female; Fetal Resorption; Injec | 1986 |