phenytoin has been researched along with Fetal Death in 22 studies
Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The toxic interaction of caffeine and phenytoin during pregnancy was investigated in mice of the ICR strain on E10 of gestation." | 7.67 | The toxicology of chemical interactions during pregnancy in the mouse: caffeine and phenytoin. ( Kwasigroch, TE; Poche, PD; Skalko, RG, 1984) |
| "Mice of the A/J and C57BL/6J (C57) strains were dosed with phenytoin (PHT) every 48 hr throughout pregnancy by gastric intubation to test the hypothesis that maternal plasma PHT concentration may be the significant factor in determining PHT reproductive and developmental toxicity." | 3.68 | Phenytoin teratogenicity and midgestational pharmacokinetics in mice. ( Laborde, JB; Roberts, LG; Slikker, W, 1991) |
| "The toxic interaction of caffeine and phenytoin during pregnancy was investigated in mice of the ICR strain on E10 of gestation." | 3.67 | The toxicology of chemical interactions during pregnancy in the mouse: caffeine and phenytoin. ( Kwasigroch, TE; Poche, PD; Skalko, RG, 1984) |
| "Fluconazole (FCZ) is an antifungal bis-triazole with potent inhibitory effect on the principal CYP-dependent metabolic pathway of PHT." | 2.69 | Teratological interaction between the bis-triazole antifungal agent fluconazole and the anticonvulsant drug phenytoin. ( Bellati, U; Di Ilio, C; Giampietro, F; Iammarrone, E; Lamonaca, D; Tiboni, GM, 1999) |
| " Pharmacokinetic data correlated well with pregnancy outcome data." | 1.31 | Pharmacokinetic data support pharmacologically induced embryonic dysrhythmia as explanation to Fetal Hydantoin Syndrome in rats. ( Azarbayjani, F; Danielsson, B; Ohman, I; Sköld, AC; Webster, W, 2000) |
| " A dose-response study was followed by a detailed teratological study using a single dose of 3 mg." | 1.28 | Teratogenic effects of phenytoin on chick embryos. ( Shah, GL; Singh, M, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (68.18) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 3 (13.64) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meador, KJ | 1 |
| Baker, GA | 1 |
| Finnell, RH | 1 |
| Kalayjian, LA | 1 |
| Liporace, JD | 1 |
| Loring, DW | 1 |
| Mawer, G | 1 |
| Pennell, PB | 1 |
| Smith, JC | 1 |
| Wolff, MC | 1 |
| Rodriguez, G | 1 |
| Trent, JT | 1 |
| Mirzabeigi, M | 1 |
| Zaulyanov, L | 1 |
| Bruce, J | 1 |
| Vincek, V | 1 |
| Hiilesmaa, VK | 1 |
| Teramo, K | 1 |
| Granström, ML | 1 |
| Bardy, AH | 1 |
| Skalko, RG | 1 |
| Poche, PD | 1 |
| Kwasigroch, TE | 1 |
| Chhabra, RS | 1 |
| Bucher, JR | 1 |
| Haseman, JK | 1 |
| Elwell, MR | 1 |
| Kurtz, PJ | 1 |
| Carlton, BD | 1 |
| Tiboni, GM | 1 |
| Iammarrone, E | 1 |
| Giampietro, F | 1 |
| Lamonaca, D | 1 |
| Bellati, U | 1 |
| Di Ilio, C | 1 |
| Danielsson, B | 1 |
| Sköld, AC | 1 |
| Azarbayjani, F | 1 |
| Ohman, I | 1 |
| Webster, W | 1 |
| Fritz, H | 1 |
| Miller, RP | 1 |
| Becker, BA | 3 |
| Biale, Y | 1 |
| Lewenthal, H | 1 |
| Aderet, NB | 1 |
| Roberts, LG | 1 |
| Laborde, JB | 1 |
| Slikker, W | 1 |
| Collins, MD | 1 |
| Fradkin, R | 1 |
| Scott, WJ | 1 |
| Wells, PG | 1 |
| Vo, HP | 1 |
| Singh, M | 1 |
| Shah, GL | 1 |
| Barcellona, PS | 1 |
| Barale, R | 1 |
| Campana, A | 1 |
| Zucconi, D | 1 |
| Rossi, V | 1 |
| Caranti, S | 1 |
| Stumpf, DA | 1 |
| Schardein, JL | 1 |
| Dresner, AJ | 1 |
| Hentz, DL | 1 |
| Petrere, JA | 1 |
| Fitzgerald, JE | 1 |
| Kurtz, SM | 1 |
| Fedrick, J | 1 |
| Harbison, RD | 2 |
| Gabler, WL | 1 |
| Sinclair, JG | 1 |
| Abreu, BE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neurodevelopmental Effects of Antiepileptic Drugs II: the NEAD Study[NCT00021866] | 331 participants (Actual) | Observational | 2000-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for phenytoin and Fetal Death
| Article | Year |
|---|---|
In utero antiepileptic drug exposure: fetal death and malformations.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Cognition; Female; Fetal Death; | 2006 |
Teratological interaction between the bis-triazole antifungal agent fluconazole and the anticonvulsant drug phenytoin.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Antifungal Agents; Body Weight; Cleft Palate; | 1999 |
20 other studies available for phenytoin and Fetal Death
| Article | Year |
|---|---|
Toxic epidermal necrolysis in a mother and fetus.
Topics: Adolescent; Anticonvulsants; Biopsy; Epilepsy; Female; Fetal Death; Fetus; Humans; Infectious Diseas | 2006 |
Serum folate concentrations during pregnancy in women with epilepsy: relation to antiepileptic drug concentrations, number of seizures, and fetal outcome.
Topics: Carbamazepine; Congenital Abnormalities; Epilepsy; Female; Fetal Death; Folic Acid; Humans; Phenobar | 1983 |
The toxicology of chemical interactions during pregnancy in the mouse: caffeine and phenytoin.
Topics: Animals; Caffeine; Drug Interactions; Female; Fetal Death; Fetal Resorption; Mice; Mice, Inbred ICR; | 1984 |
Comparative carcinogenicity of 5,5-diphenylhydantoin with or without perinatal exposure in rats and mice.
Topics: Adenoma, Liver Cell; Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Female; Fetal Dea | 1993 |
Pharmacokinetic data support pharmacologically induced embryonic dysrhythmia as explanation to Fetal Hydantoin Syndrome in rats.
Topics: Abnormalities, Drug-Induced; Animals; Arrhythmias, Cardiac; Culture Techniques; Dose-Response Relati | 2000 |
The effect of cortisone on the teratogenic action of acetylsalicylic acid and diphenylhydantoin in the mouse.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cleft Palate; Cortisone; Drug Administration Schedule | 1976 |
Teratogenicity of oral diazepam and diphenylhydantoin in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Diazepam; Female; Fetal Death; Fetu | 1975 |
Congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord | 1975 |
Phenytoin teratogenicity and midgestational pharmacokinetics in mice.
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Fetal Death; Gestati | 1991 |
Induction of postaxial forelimb ectrodactyly with anticonvulsant agents in A/J mice.
Topics: Abnormalities, Drug-Induced; Animals; Birth Weight; Dimethadione; Female; Fetal Death; Fetal Resorpt | 1990 |
Effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on phenytoin-induced embryopathy in mice.
Topics: Animals; Dose-Response Relationship, Drug; Female; Fetal Death; Fetal Resorption; Fetus; Mice; Pheny | 1989 |
Teratogenic effects of phenytoin on chick embryos.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Chick Embryo; Dose-Response Relationship, Drug; E | 1989 |
Correlations between embryotoxic and genotoxic effects of phenytoin in mice.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Cell Nucleus; Cytochrome P-450 CYP1A2; Cyto | 1987 |
Anticonvulsant use during pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Death; Humans; Phenobarbital; | 1985 |
The modifying effect of folinic acid on diphenylhydantoin-induced teratogenicity in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fetal Death; Fetus; Leucovorin; Mice; Or | 1973 |
Epilepsy and pregnancy: a report from the Oxford Record Linkage Study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Child; Congenital Abnormalities; Drug S | 1973 |
Diphenylhydantoin teratogenicity in rats.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Cleft Palate; Female; Fetal Death | 1972 |
Relation of dosage and time of administration of diphenylhydantoin to its teratogenic effect in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Lip; Cleft Palate; Embryonic and Fetal Deve | 1969 |
The effect of 5,5-diphenylhydantoin on the rat uterus and its fetuses.
Topics: Animals; Body Weight; Collagen; Female; Fetal Death; Fetus; Hydroxyproline; Nitrogen; Organ Size; Ph | 1968 |
Transplacental effects of drugs in mice.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Male; Maternal-Fetal Exchange; Methylcell | 1965 |