phenytoin has been researched along with Exanthema in 34 studies
Exanthema: Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Over last fifty years, intravenous (iv) phenytoin (PHT) loading dose has been the treatment of choice for patients with benzodiazepine-resistant convulsive status epilepticus and several guidelines recommended this treatment regimen with simultaneous iv diazepam." | 8.98 | Why we prefer levetiracetam over phenytoin for treatment of status epilepticus. ( Amantini, A; Campostrini, R; Giannasi, G; Giorgi, FS; Giovannelli, F; Nazerian, P; Paganini, M; Zaccara, G, 2018) |
| " Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) is a very serious but rare adverse effect of anticonvulsants such as carbamazepine and phenytoin; however, the reported incidence on zonisamide is scant." | 8.12 | Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a paediatric patient taking zonisamide. ( Govindan, R; Sharma, S; Trivedi, A, 2022) |
| "We report one case of phenytoin-induced DRESS syndrome in a 34-year-old man, previously on phenytoin for seizure prophylaxis, who presented to the ED with 5 days of worsening symptoms including generalized rash, fever, tongue swelling, and dysphagia." | 7.79 | Phenytoin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a case report from the emergency department. ( Oelze, LL; Pillow, MT, 2013) |
| "Phenytoin, one of the most common antiepileptic drugs, is a major cause of antiepileptic drug hypersensitivity syndrome (AHS), which is a rare but potentially fatal complication." | 7.75 | Agranulocytosis following phenytoin-induced hypersensitivity syndrome. ( Imai, K; Ito, S; Oguni, H; Osawa, M; Sasaki, K; Shioda, M, 2009) |
| "Levetiracetam was stopped and she improved after treatment with norepinephrine, antihistamines and corticosteroids." | 5.38 | Levetiracetam induced angioedema in a patient with previous anticonvulsant hypersensitivity reaction to phenytoin and lamotrigine. ( Alkhotani, A; McLachlan, RS, 2012) |
| "Over last fifty years, intravenous (iv) phenytoin (PHT) loading dose has been the treatment of choice for patients with benzodiazepine-resistant convulsive status epilepticus and several guidelines recommended this treatment regimen with simultaneous iv diazepam." | 4.98 | Why we prefer levetiracetam over phenytoin for treatment of status epilepticus. ( Amantini, A; Campostrini, R; Giannasi, G; Giorgi, FS; Giovannelli, F; Nazerian, P; Paganini, M; Zaccara, G, 2018) |
| "The antiepileptic drug hypersensitivity syndrome (AHS) is an adverse drug reaction associated with the aromatic antiepileptic drugs (AEDs) phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), and primidone." | 4.80 | Antiepileptic drug hypersensitivity syndrome. ( Schlienger, RG; Shear, NH, 1998) |
| " Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) is a very serious but rare adverse effect of anticonvulsants such as carbamazepine and phenytoin; however, the reported incidence on zonisamide is scant." | 4.12 | Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a paediatric patient taking zonisamide. ( Govindan, R; Sharma, S; Trivedi, A, 2022) |
| "We report one case of phenytoin-induced DRESS syndrome in a 34-year-old man, previously on phenytoin for seizure prophylaxis, who presented to the ED with 5 days of worsening symptoms including generalized rash, fever, tongue swelling, and dysphagia." | 3.79 | Phenytoin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a case report from the emergency department. ( Oelze, LL; Pillow, MT, 2013) |
| " All had dermatological manifestations, eosinophilia and systemic (haematological and hepatic) manifestations that could be attributed to treatment with aromatic AEDs (carbamazepine, 2 patients; lamotrigine, 3 patients; phenytoin, 3 patients)." | 3.77 | Risk factors associated with DRESS syndrome produced by aromatic and non-aromatic antipiletic drugs. ( Kochen, S; Pereira de Silva, N; Piquioni, P; Saidon, P, 2011) |
| "Phenytoin, one of the most common antiepileptic drugs, is a major cause of antiepileptic drug hypersensitivity syndrome (AHS), which is a rare but potentially fatal complication." | 3.75 | Agranulocytosis following phenytoin-induced hypersensitivity syndrome. ( Imai, K; Ito, S; Oguni, H; Osawa, M; Sasaki, K; Shioda, M, 2009) |
| "Seven patients who presented with phenytoin-induced maculopapular exanthema with and without fever were included in this study." | 3.74 | Allergen-specific T-cell response in patients with phenytoin hypersensitivity; simultaneous analysis of proliferation and cytokine production by carboxyfluorescein succinimidyl ester (CFSE) dilution assay. ( Itomi, S; Kakami, M; Kawamura, M; Komatsubara, R; Kondo, Y; Nakajima, Y; Okumura, A; Tsuge, I; Urisu, A, 2007) |
| " The aim of this study was to study the frequency and nature of cutaneous reactions in a cohort of patients being treated with phenytoin sodium for seizures, who were divided into those with a solitary cysticercus granuloma (SCG) and those with a condition other than SCG, to determine if the presence of SCG increases the risk of cutaneous adverse reaction to phenytoin." | 3.72 | Cutaneous reactions in patients with solitary cysticercus granuloma on phenytoin sodium. ( Chander Chopra, S; Gupta, M; Kaushal, S; Singh, G, 2004) |
| "Carbamazepine or phenytoin was withdrawn over the next 4 weeks; then patients entered a 12-week monotherapy period." | 2.69 | An active-control trial of lamotrigine monotherapy for partial seizures. ( Chang, GY; Gilliam, F; Messenheimer, J; Nyberg, J; Risner, ME; Rudd, GD; Sackellares, JC; Vazquez, B, 1998) |
| "DRESS Syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) is an uncommon disease caused by drugs." | 1.42 | [DRESS syndrome: Report of nine cases]. ( Barbosa-Moreno, LE; Guerrero-González, GA; Martínez-Villarreal, JD; Ocampo-Candiani, J; Ocampo-Garza, J; Ocampo-Garza, SS, 2015) |
| "Levetiracetam was stopped and she improved after treatment with norepinephrine, antihistamines and corticosteroids." | 1.38 | Levetiracetam induced angioedema in a patient with previous anticonvulsant hypersensitivity reaction to phenytoin and lamotrigine. ( Alkhotani, A; McLachlan, RS, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (32.35) | 18.7374 |
| 1990's | 4 (11.76) | 18.2507 |
| 2000's | 6 (17.65) | 29.6817 |
| 2010's | 11 (32.35) | 24.3611 |
| 2020's | 2 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Trivedi, A | 1 |
| Sharma, S | 1 |
| Govindan, R | 1 |
| Guerrini, R | 1 |
| Perucca, E | 1 |
| Zaccara, G | 1 |
| Giorgi, FS | 1 |
| Amantini, A | 1 |
| Giannasi, G | 1 |
| Campostrini, R | 1 |
| Giovannelli, F | 1 |
| Paganini, M | 1 |
| Nazerian, P | 1 |
| Stega, J | 1 |
| Noel, MS | 1 |
| Vandell, AG | 1 |
| Stega, D | 1 |
| Del Priore, G | 1 |
| Hoffman, S | 1 |
| Keel, BR | 1 |
| Payne, CL | 1 |
| Ocampo-Garza, J | 1 |
| Ocampo-Garza, SS | 1 |
| Martínez-Villarreal, JD | 1 |
| Barbosa-Moreno, LE | 1 |
| Guerrero-González, GA | 1 |
| Ocampo-Candiani, J | 1 |
| Gleeson, TP | 1 |
| Griswold, MK | 1 |
| Broach, J | 1 |
| Babu, KM | 1 |
| Ito, S | 1 |
| Shioda, M | 1 |
| Sasaki, K | 1 |
| Imai, K | 1 |
| Oguni, H | 1 |
| Osawa, M | 1 |
| Wang, XQ | 1 |
| Lang, SY | 1 |
| Shi, XB | 1 |
| Tian, HJ | 1 |
| Wang, RF | 1 |
| Yang, F | 1 |
| Pereira de Silva, N | 1 |
| Piquioni, P | 1 |
| Kochen, S | 1 |
| Saidon, P | 1 |
| Oelze, LL | 1 |
| Pillow, MT | 1 |
| Yang, CY | 1 |
| Dao, RL | 1 |
| Lee, TJ | 1 |
| Lu, CW | 1 |
| Yang, CH | 1 |
| Hung, SI | 1 |
| Chung, WH | 1 |
| Lonati, D | 1 |
| Zancan, A | 1 |
| Giampreti, A | 1 |
| Sparpaglione, D | 1 |
| Locatelli, CA | 1 |
| Manzo, L | 1 |
| Alkhotani, A | 1 |
| McLachlan, RS | 1 |
| Monks, G | 1 |
| Crowson, AN | 1 |
| Cornelison, R | 1 |
| Naylor, M | 1 |
| EISSNER, H | 1 |
| MELCHIOR, JC | 1 |
| SVENSMARK, O | 1 |
| Singh, G | 1 |
| Kaushal, S | 1 |
| Gupta, M | 1 |
| Chander Chopra, S | 1 |
| SWEET, RD | 1 |
| Ajith, C | 1 |
| Dogra, S | 1 |
| Handa, S | 1 |
| Tsuge, I | 1 |
| Okumura, A | 1 |
| Kondo, Y | 1 |
| Itomi, S | 1 |
| Kakami, M | 1 |
| Kawamura, M | 1 |
| Nakajima, Y | 1 |
| Komatsubara, R | 1 |
| Urisu, A | 1 |
| Gupta, R | 1 |
| Gupta, S | 1 |
| Vandvik, IH | 1 |
| DeSwarte, RD | 1 |
| Bamberg, M | 1 |
| Tamulevicius, P | 1 |
| Streffer, C | 1 |
| Scherer, E | 1 |
| Vellucci, A | 1 |
| Galanti, G | 1 |
| Pezzella, B | 1 |
| De Longis, P | 1 |
| Colacecchi, C | 1 |
| Tugendhaft, P | 1 |
| Simonart, T | 1 |
| Gilliam, F | 1 |
| Vazquez, B | 1 |
| Sackellares, JC | 1 |
| Chang, GY | 1 |
| Messenheimer, J | 1 |
| Nyberg, J | 1 |
| Risner, ME | 1 |
| Rudd, GD | 1 |
| Schlienger, RG | 1 |
| Shear, NH | 1 |
| Basak, P | 1 |
| Kanwar, AJ | 1 |
| Mistri, G | 1 |
| Robinson, HM | 1 |
| Stone, JH | 1 |
| Schulz, KH | 1 |
| Lalla, M | 1 |
| Virolainen, M | 1 |
| From, E | 1 |
| Simonsen, EE | 1 |
2 reviews available for phenytoin and Exanthema
| Article | Year |
|---|---|
Why we prefer levetiracetam over phenytoin for treatment of status epilepticus.
Topics: Administration, Cutaneous; Administration, Intravenous; Anticonvulsants; Exanthema; Humans; Infusion | 2018 |
Antiepileptic drug hypersensitivity syndrome.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross Reactions; Diagnosis, Differential; D | 1998 |
2 trials available for phenytoin and Exanthema
| Article | Year |
|---|---|
A first-in-human study of the novel metabolism-based anti-cancer agent SM-88 in subjects with advanced metastatic cancer.
Topics: Aged; alpha-Methyltyrosine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; E | 2020 |
An active-control trial of lamotrigine monotherapy for partial seizures.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Double-Blind Method; Epilepsies, Partial; E | 1998 |
30 other studies available for phenytoin and Exanthema
| Article | Year |
|---|---|
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a paediatric patient taking zonisamide.
Topics: Child; Drug Hypersensitivity Syndrome; Eosinophilia; Exanthema; Humans; Male; Phenytoin; Zonisamide | 2022 |
Genetic testing to prevent adverse reactions to antiepileptic drugs: Primum non nocere.
Topics: Anticonvulsants; Exanthema; Genetic Testing; Genetic Variation; Humans; Phenytoin | 2018 |
Anticonvulsant hypersensitivity syndrome (AHS): a case report.
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Exanthema; Fe | 2013 |
[DRESS syndrome: Report of nine cases].
Topics: Adolescent; Adult; Aged; Carbamazepine; Dexamethasone; Drug Hypersensitivity Syndrome; Eosinophilia; | 2015 |
What is This Rash?
Topics: Adrenal Cortex Hormones; Adult; Anticonvulsants; Drug Hypersensitivity Syndrome; Drug Substitution; | 2016 |
Agranulocytosis following phenytoin-induced hypersensitivity syndrome.
Topics: Agranulocytosis; Anti-Bacterial Agents; Anticonvulsants; Cefepime; Cephalosporins; Chemical and Drug | 2009 |
Cross-reactivity of skin rashes with current antiepileptic drugs in Chinese population.
Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Child; Chi | 2010 |
Risk factors associated with DRESS syndrome produced by aromatic and non-aromatic antipiletic drugs.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anticonvulsants; Carbamazepine; Disease Susceptibility; | 2011 |
Phenytoin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a case report from the emergency department.
Topics: Adult; Angioedema; Anticonvulsants; Drug Eruptions; Emergency Service, Hospital; Eosinophilia; Exant | 2013 |
Severe cutaneous adverse reactions to antiepileptic drugs in Asians.
Topics: Adult; Anticonvulsants; Asian People; Carbamazepine; Exanthema; Female; Follow-Up Studies; Humans; L | 2011 |
An insidious skin rash without itch.
Topics: Aged; Anticonvulsants; Exanthema; Female; Humans; Phenytoin; Pruritus; Stevens-Johnson Syndrome | 2012 |
Levetiracetam induced angioedema in a patient with previous anticonvulsant hypersensitivity reaction to phenytoin and lamotrigine.
Topics: Adult; Angioedema; Anticonvulsants; Exanthema; Female; Humans; Lamotrigine; Levetiracetam; Phenytoin | 2012 |
A case of phenytoin hypersensitivity syndrome.
Topics: Adolescent; Anticonvulsants; Drug Hypersensitivity; Exanthema; Female; Humans; Lymphatic Diseases; P | 2002 |
[Diphenylhydantoin exanthema in the form of an infectious mononucleosis].
Topics: Exanthema; Humans; Hydantoins; Infectious Mononucleosis; Phenytoin | 1960 |
A case of phenytoin hypersensitivity.
Topics: Drug Hypersensitivity; Exanthema; Humans; Phenytoin | 1963 |
Cutaneous reactions in patients with solitary cysticercus granuloma on phenytoin sodium.
Topics: Adult; Anticonvulsants; Drug Hypersensitivity; Exanthema; Female; Granuloma, Foreign-Body; Humans; M | 2004 |
A fixed skin eruption due to phenytoin sodium.
Topics: Exanthema; Humans; Hydantoins; Pharmaceutical Preparations; Phenytoin | 1950 |
Kaposi's varicelliform eruption in a patient with phenytoin-induced drug rash.
Topics: Acyclovir; Anti-Bacterial Agents; Anticonvulsants; Antiviral Agents; Exanthema; Female; Humans; Kapo | 2006 |
Allergen-specific T-cell response in patients with phenytoin hypersensitivity; simultaneous analysis of proliferation and cytokine production by carboxyfluorescein succinimidyl ester (CFSE) dilution assay.
Topics: Adolescent; Allergens; Anticonvulsants; Case-Control Studies; CD4 Antigens; Cell Proliferation; Cell | 2007 |
Exanthematous allergic drug reactions due to four chemically unrelated drugs.
Topics: Adult; Antibiotics, Antitubercular; Anticonvulsants; Antitubercular Agents; Erythema; Ethambutol; Ex | 2008 |
[Toxic epidermal necrolysis. Epidermolysis necroticans combustiforme].
Topics: Child, Preschool; Exanthema; Humans; Male; Phenobarbital; Phenytoin; Stevens-Johnson Syndrome | 1967 |
Drug allergy--problems and strategies.
Topics: Anaphylaxis; Anemia, Hemolytic; Antigen-Antibody Complex; Desensitization, Immunologic; Dose-Respons | 1984 |
[Clinical experiences with the radiosensitizer Misonidazol (author's transl)].
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Dexamethasone; Drug Interactions; Esophageal Neoplasms; Ex | 1981 |
[Case of "exanthematous pseudolymphoma" due to diphenylhydantoin hypersensitivity with a transitory immunologic deficit].
Topics: Adolescent; Drug Hypersensitivity; Exanthema; Humans; Immunologic Deficiency Syndromes; Lymphoma; Ma | 1980 |
Phenytoin-like hypersensitivity associated with lamotrigine.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Eruptions; Exanthema; Humans; Lamotrigine; P | 1998 |
Drug rash in a hemiplegic.
Topics: Adolescent; Exanthema; Hemiplegia; Humans; Male; Phenytoin | 1990 |
Exanthem due to diphenylhydantoin therapy.
Topics: Adolescent; Alkaline Phosphatase; Blood Chemical Analysis; Blood Urea Nitrogen; Drug Eruptions; Edem | 1970 |
[Lymphocyte transformation test in drug hypersensitivity].
Topics: Ampicillin; Drug Hypersensitivity; Exanthema; Humans; Immunologic Techniques; Lymphocyte Activation; | 1972 |
Blood lymphoblast proliferation in vivo in cutaneous drug hypersensitivity reactions.
Topics: Blood Cell Count; Carbamazepine; Chlorpromazine; Drug Hypersensitivity; Exanthema; Humans; Lymphocyt | 1974 |
[Febrile toxic hepatitis with eosinophilia, lymphadenopathy and exanthema during phenytoin therapy].
Topics: Adult; Chemical and Drug Induced Liver Injury; Eosinophilia; Exanthema; Fever; Humans; Liver Functio | 1971 |