phenytoin has been researched along with Exanthem in 34 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Over last fifty years, intravenous (iv) phenytoin (PHT) loading dose has been the treatment of choice for patients with benzodiazepine-resistant convulsive status epilepticus and several guidelines recommended this treatment regimen with simultaneous iv diazepam." | 8.98 | Why we prefer levetiracetam over phenytoin for treatment of status epilepticus. ( Amantini, A; Campostrini, R; Giannasi, G; Giorgi, FS; Giovannelli, F; Nazerian, P; Paganini, M; Zaccara, G, 2018) |
| " Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) is a very serious but rare adverse effect of anticonvulsants such as carbamazepine and phenytoin; however, the reported incidence on zonisamide is scant." | 8.12 | Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a paediatric patient taking zonisamide. ( Govindan, R; Sharma, S; Trivedi, A, 2022) |
| "We report one case of phenytoin-induced DRESS syndrome in a 34-year-old man, previously on phenytoin for seizure prophylaxis, who presented to the ED with 5 days of worsening symptoms including generalized rash, fever, tongue swelling, and dysphagia." | 7.79 | Phenytoin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a case report from the emergency department. ( Oelze, LL; Pillow, MT, 2013) |
| "Phenytoin, one of the most common antiepileptic drugs, is a major cause of antiepileptic drug hypersensitivity syndrome (AHS), which is a rare but potentially fatal complication." | 7.75 | Agranulocytosis following phenytoin-induced hypersensitivity syndrome. ( Imai, K; Ito, S; Oguni, H; Osawa, M; Sasaki, K; Shioda, M, 2009) |
| "Levetiracetam was stopped and she improved after treatment with norepinephrine, antihistamines and corticosteroids." | 5.38 | Levetiracetam induced angioedema in a patient with previous anticonvulsant hypersensitivity reaction to phenytoin and lamotrigine. ( Alkhotani, A; McLachlan, RS, 2012) |
| "Over last fifty years, intravenous (iv) phenytoin (PHT) loading dose has been the treatment of choice for patients with benzodiazepine-resistant convulsive status epilepticus and several guidelines recommended this treatment regimen with simultaneous iv diazepam." | 4.98 | Why we prefer levetiracetam over phenytoin for treatment of status epilepticus. ( Amantini, A; Campostrini, R; Giannasi, G; Giorgi, FS; Giovannelli, F; Nazerian, P; Paganini, M; Zaccara, G, 2018) |
| "The antiepileptic drug hypersensitivity syndrome (AHS) is an adverse drug reaction associated with the aromatic antiepileptic drugs (AEDs) phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), and primidone." | 4.80 | Antiepileptic drug hypersensitivity syndrome. ( Schlienger, RG; Shear, NH, 1998) |
| " Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) is a very serious but rare adverse effect of anticonvulsants such as carbamazepine and phenytoin; however, the reported incidence on zonisamide is scant." | 4.12 | Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a paediatric patient taking zonisamide. ( Govindan, R; Sharma, S; Trivedi, A, 2022) |
| "We report one case of phenytoin-induced DRESS syndrome in a 34-year-old man, previously on phenytoin for seizure prophylaxis, who presented to the ED with 5 days of worsening symptoms including generalized rash, fever, tongue swelling, and dysphagia." | 3.79 | Phenytoin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a case report from the emergency department. ( Oelze, LL; Pillow, MT, 2013) |
| " All had dermatological manifestations, eosinophilia and systemic (haematological and hepatic) manifestations that could be attributed to treatment with aromatic AEDs (carbamazepine, 2 patients; lamotrigine, 3 patients; phenytoin, 3 patients)." | 3.77 | Risk factors associated with DRESS syndrome produced by aromatic and non-aromatic antipiletic drugs. ( Kochen, S; Pereira de Silva, N; Piquioni, P; Saidon, P, 2011) |
| "Phenytoin, one of the most common antiepileptic drugs, is a major cause of antiepileptic drug hypersensitivity syndrome (AHS), which is a rare but potentially fatal complication." | 3.75 | Agranulocytosis following phenytoin-induced hypersensitivity syndrome. ( Imai, K; Ito, S; Oguni, H; Osawa, M; Sasaki, K; Shioda, M, 2009) |
| "Seven patients who presented with phenytoin-induced maculopapular exanthema with and without fever were included in this study." | 3.74 | Allergen-specific T-cell response in patients with phenytoin hypersensitivity; simultaneous analysis of proliferation and cytokine production by carboxyfluorescein succinimidyl ester (CFSE) dilution assay. ( Itomi, S; Kakami, M; Kawamura, M; Komatsubara, R; Kondo, Y; Nakajima, Y; Okumura, A; Tsuge, I; Urisu, A, 2007) |
| " The aim of this study was to study the frequency and nature of cutaneous reactions in a cohort of patients being treated with phenytoin sodium for seizures, who were divided into those with a solitary cysticercus granuloma (SCG) and those with a condition other than SCG, to determine if the presence of SCG increases the risk of cutaneous adverse reaction to phenytoin." | 3.72 | Cutaneous reactions in patients with solitary cysticercus granuloma on phenytoin sodium. ( Chander Chopra, S; Gupta, M; Kaushal, S; Singh, G, 2004) |
| "Carbamazepine or phenytoin was withdrawn over the next 4 weeks; then patients entered a 12-week monotherapy period." | 2.69 | An active-control trial of lamotrigine monotherapy for partial seizures. ( Chang, GY; Gilliam, F; Messenheimer, J; Nyberg, J; Risner, ME; Rudd, GD; Sackellares, JC; Vazquez, B, 1998) |
| "DRESS Syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) is an uncommon disease caused by drugs." | 1.42 | [DRESS syndrome: Report of nine cases]. ( Barbosa-Moreno, LE; Guerrero-González, GA; Martínez-Villarreal, JD; Ocampo-Candiani, J; Ocampo-Garza, J; Ocampo-Garza, SS, 2015) |
| "Levetiracetam was stopped and she improved after treatment with norepinephrine, antihistamines and corticosteroids." | 1.38 | Levetiracetam induced angioedema in a patient with previous anticonvulsant hypersensitivity reaction to phenytoin and lamotrigine. ( Alkhotani, A; McLachlan, RS, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (32.35) | 18.7374 |
| 1990's | 4 (11.76) | 18.2507 |
| 2000's | 6 (17.65) | 29.6817 |
| 2010's | 11 (32.35) | 24.3611 |
| 2020's | 2 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Trivedi, A | 1 |
| Sharma, S | 1 |
| Govindan, R | 1 |
| Guerrini, R | 1 |
| Perucca, E | 1 |
| Zaccara, G | 1 |
| Giorgi, FS | 1 |
| Amantini, A | 1 |
| Giannasi, G | 1 |
| Campostrini, R | 1 |
| Giovannelli, F | 1 |
| Paganini, M | 1 |
| Nazerian, P | 1 |
| Stega, J | 1 |
| Noel, MS | 1 |
| Vandell, AG | 1 |
| Stega, D | 1 |
| Del Priore, G | 1 |
| Hoffman, S | 1 |
| Keel, BR | 1 |
| Payne, CL | 1 |
| Ocampo-Garza, J | 1 |
| Ocampo-Garza, SS | 1 |
| Martínez-Villarreal, JD | 1 |
| Barbosa-Moreno, LE | 1 |
| Guerrero-González, GA | 1 |
| Ocampo-Candiani, J | 1 |
| Gleeson, TP | 1 |
| Griswold, MK | 1 |
| Broach, J | 1 |
| Babu, KM | 1 |
| Ito, S | 1 |
| Shioda, M | 1 |
| Sasaki, K | 1 |
| Imai, K | 1 |
| Oguni, H | 1 |
| Osawa, M | 1 |
| Wang, XQ | 1 |
| Lang, SY | 1 |
| Shi, XB | 1 |
| Tian, HJ | 1 |
| Wang, RF | 1 |
| Yang, F | 1 |
| Pereira de Silva, N | 1 |
| Piquioni, P | 1 |
| Kochen, S | 1 |
| Saidon, P | 1 |
| Oelze, LL | 1 |
| Pillow, MT | 1 |
| Yang, CY | 1 |
| Dao, RL | 1 |
| Lee, TJ | 1 |
| Lu, CW | 1 |
| Yang, CH | 1 |
| Hung, SI | 1 |
| Chung, WH | 1 |
| Lonati, D | 1 |
| Zancan, A | 1 |
| Giampreti, A | 1 |
| Sparpaglione, D | 1 |
| Locatelli, CA | 1 |
| Manzo, L | 1 |
| Alkhotani, A | 1 |
| McLachlan, RS | 1 |
| Monks, G | 1 |
| Crowson, AN | 1 |
| Cornelison, R | 1 |
| Naylor, M | 1 |
| EISSNER, H | 1 |
| MELCHIOR, JC | 1 |
| SVENSMARK, O | 1 |
| Singh, G | 1 |
| Kaushal, S | 1 |
| Gupta, M | 1 |
| Chander Chopra, S | 1 |
| SWEET, RD | 1 |
| Ajith, C | 1 |
| Dogra, S | 1 |
| Handa, S | 1 |
| Tsuge, I | 1 |
| Okumura, A | 1 |
| Kondo, Y | 1 |
| Itomi, S | 1 |
| Kakami, M | 1 |
| Kawamura, M | 1 |
| Nakajima, Y | 1 |
| Komatsubara, R | 1 |
| Urisu, A | 1 |
| Gupta, R | 1 |
| Gupta, S | 1 |
| Vandvik, IH | 1 |
| DeSwarte, RD | 1 |
| Bamberg, M | 1 |
| Tamulevicius, P | 1 |
| Streffer, C | 1 |
| Scherer, E | 1 |
| Vellucci, A | 1 |
| Galanti, G | 1 |
| Pezzella, B | 1 |
| De Longis, P | 1 |
| Colacecchi, C | 1 |
| Tugendhaft, P | 1 |
| Simonart, T | 1 |
| Gilliam, F | 1 |
| Vazquez, B | 1 |
| Sackellares, JC | 1 |
| Chang, GY | 1 |
| Messenheimer, J | 1 |
| Nyberg, J | 1 |
| Risner, ME | 1 |
| Rudd, GD | 1 |
| Schlienger, RG | 1 |
| Shear, NH | 1 |
| Basak, P | 1 |
| Kanwar, AJ | 1 |
| Mistri, G | 1 |
| Robinson, HM | 1 |
| Stone, JH | 1 |
| Schulz, KH | 1 |
| Lalla, M | 1 |
| Virolainen, M | 1 |
| From, E | 1 |
| Simonsen, EE | 1 |
2 reviews available for phenytoin and Exanthem
| Article | Year |
|---|---|
Why we prefer levetiracetam over phenytoin for treatment of status epilepticus.
Topics: Administration, Cutaneous; Administration, Intravenous; Anticonvulsants; Exanthema; Humans; Infusion | 2018 |
Antiepileptic drug hypersensitivity syndrome.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross Reactions; Diagnosis, Differential; D | 1998 |
2 trials available for phenytoin and Exanthem
| Article | Year |
|---|---|
A first-in-human study of the novel metabolism-based anti-cancer agent SM-88 in subjects with advanced metastatic cancer.
Topics: Aged; alpha-Methyltyrosine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; E | 2020 |
An active-control trial of lamotrigine monotherapy for partial seizures.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Double-Blind Method; Epilepsies, Partial; E | 1998 |
30 other studies available for phenytoin and Exanthem
| Article | Year |
|---|---|
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a paediatric patient taking zonisamide.
Topics: Child; Drug Hypersensitivity Syndrome; Eosinophilia; Exanthema; Humans; Male; Phenytoin; Zonisamide | 2022 |
Genetic testing to prevent adverse reactions to antiepileptic drugs: Primum non nocere.
Topics: Anticonvulsants; Exanthema; Genetic Testing; Genetic Variation; Humans; Phenytoin | 2018 |
Anticonvulsant hypersensitivity syndrome (AHS): a case report.
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Exanthema; Fe | 2013 |
[DRESS syndrome: Report of nine cases].
Topics: Adolescent; Adult; Aged; Carbamazepine; Dexamethasone; Drug Hypersensitivity Syndrome; Eosinophilia; | 2015 |
What is This Rash?
Topics: Adrenal Cortex Hormones; Adult; Anticonvulsants; Drug Hypersensitivity Syndrome; Drug Substitution; | 2016 |
Agranulocytosis following phenytoin-induced hypersensitivity syndrome.
Topics: Agranulocytosis; Anti-Bacterial Agents; Anticonvulsants; Cefepime; Cephalosporins; Chemical and Drug | 2009 |
Cross-reactivity of skin rashes with current antiepileptic drugs in Chinese population.
Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Child; Chi | 2010 |
Risk factors associated with DRESS syndrome produced by aromatic and non-aromatic antipiletic drugs.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anticonvulsants; Carbamazepine; Disease Susceptibility; | 2011 |
Phenytoin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a case report from the emergency department.
Topics: Adult; Angioedema; Anticonvulsants; Drug Eruptions; Emergency Service, Hospital; Eosinophilia; Exant | 2013 |
Severe cutaneous adverse reactions to antiepileptic drugs in Asians.
Topics: Adult; Anticonvulsants; Asian People; Carbamazepine; Exanthema; Female; Follow-Up Studies; Humans; L | 2011 |
An insidious skin rash without itch.
Topics: Aged; Anticonvulsants; Exanthema; Female; Humans; Phenytoin; Pruritus; Stevens-Johnson Syndrome | 2012 |
Levetiracetam induced angioedema in a patient with previous anticonvulsant hypersensitivity reaction to phenytoin and lamotrigine.
Topics: Adult; Angioedema; Anticonvulsants; Exanthema; Female; Humans; Lamotrigine; Levetiracetam; Phenytoin | 2012 |
A case of phenytoin hypersensitivity syndrome.
Topics: Adolescent; Anticonvulsants; Drug Hypersensitivity; Exanthema; Female; Humans; Lymphatic Diseases; P | 2002 |
[Diphenylhydantoin exanthema in the form of an infectious mononucleosis].
Topics: Exanthema; Humans; Hydantoins; Infectious Mononucleosis; Phenytoin | 1960 |
A case of phenytoin hypersensitivity.
Topics: Drug Hypersensitivity; Exanthema; Humans; Phenytoin | 1963 |
Cutaneous reactions in patients with solitary cysticercus granuloma on phenytoin sodium.
Topics: Adult; Anticonvulsants; Drug Hypersensitivity; Exanthema; Female; Granuloma, Foreign-Body; Humans; M | 2004 |
A fixed skin eruption due to phenytoin sodium.
Topics: Exanthema; Humans; Hydantoins; Pharmaceutical Preparations; Phenytoin | 1950 |
Kaposi's varicelliform eruption in a patient with phenytoin-induced drug rash.
Topics: Acyclovir; Anti-Bacterial Agents; Anticonvulsants; Antiviral Agents; Exanthema; Female; Humans; Kapo | 2006 |
Allergen-specific T-cell response in patients with phenytoin hypersensitivity; simultaneous analysis of proliferation and cytokine production by carboxyfluorescein succinimidyl ester (CFSE) dilution assay.
Topics: Adolescent; Allergens; Anticonvulsants; Case-Control Studies; CD4 Antigens; Cell Proliferation; Cell | 2007 |
Exanthematous allergic drug reactions due to four chemically unrelated drugs.
Topics: Adult; Antibiotics, Antitubercular; Anticonvulsants; Antitubercular Agents; Erythema; Ethambutol; Ex | 2008 |
[Toxic epidermal necrolysis. Epidermolysis necroticans combustiforme].
Topics: Child, Preschool; Exanthema; Humans; Male; Phenobarbital; Phenytoin; Stevens-Johnson Syndrome | 1967 |
Drug allergy--problems and strategies.
Topics: Anaphylaxis; Anemia, Hemolytic; Antigen-Antibody Complex; Desensitization, Immunologic; Dose-Respons | 1984 |
[Clinical experiences with the radiosensitizer Misonidazol (author's transl)].
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Dexamethasone; Drug Interactions; Esophageal Neoplasms; Ex | 1981 |
[Case of "exanthematous pseudolymphoma" due to diphenylhydantoin hypersensitivity with a transitory immunologic deficit].
Topics: Adolescent; Drug Hypersensitivity; Exanthema; Humans; Immunologic Deficiency Syndromes; Lymphoma; Ma | 1980 |
Phenytoin-like hypersensitivity associated with lamotrigine.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Eruptions; Exanthema; Humans; Lamotrigine; P | 1998 |
Drug rash in a hemiplegic.
Topics: Adolescent; Exanthema; Hemiplegia; Humans; Male; Phenytoin | 1990 |
Exanthem due to diphenylhydantoin therapy.
Topics: Adolescent; Alkaline Phosphatase; Blood Chemical Analysis; Blood Urea Nitrogen; Drug Eruptions; Edem | 1970 |
[Lymphocyte transformation test in drug hypersensitivity].
Topics: Ampicillin; Drug Hypersensitivity; Exanthema; Humans; Immunologic Techniques; Lymphocyte Activation; | 1972 |
Blood lymphoblast proliferation in vivo in cutaneous drug hypersensitivity reactions.
Topics: Blood Cell Count; Carbamazepine; Chlorpromazine; Drug Hypersensitivity; Exanthema; Humans; Lymphocyt | 1974 |
[Febrile toxic hepatitis with eosinophilia, lymphadenopathy and exanthema during phenytoin therapy].
Topics: Adult; Chemical and Drug Induced Liver Injury; Eosinophilia; Exanthema; Fever; Humans; Liver Functio | 1971 |