phenytoin has been researched along with Encephalopathy, Traumatic in 19 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "There was a small but clinically insignificant difference in the incidence of hyponatremia in traumatic ICH patients receiving levetiracetam vs." | 7.96 | Incidence of hyponatremia in patients given levetiracetam vs. phenytoin for early posttraumatic seizure prophylaxis. ( Bilello, JF; Davis, JW; Dirks, RC; Edmonds, NS; McCullough, KA, 2020) |
| "In this propensity score-matched cohort analysis, levetiracetam prophylaxis was ineffective in preventing seizures as the rate of seizures was similar whether patients did or did not receive the drug." | 7.83 | Levetiracetam Prophylaxis for Post-traumatic Brain Injury Seizures is Ineffective: A Propensity Score Analysis. ( Friese, R; Gruessner, A; Joseph, B; Khalil, M; Kulvatunyou, N; Latifi, R; O'Keeffe, T; Rhee, P; Wynne, J; Zangbar, B, 2016) |
| " On the basis of currently available Level III evidence, patients treated with either levetiracetam or phenytoin have similar incidences of early seizures after TBI." | 4.93 | Should Levetiracetam or Phenytoin Be Used for Posttraumatic Seizure Prophylaxis? A Systematic Review of the Literature and Meta-analysis. ( Barker, F; Evans, LT; Fierst, TM; Hoes, K; Hymel, C; Khan, NR; Klimo, P; Mayer, R; VanLandingham, MA, 2016) |
| "Patients may experience a reduced incidence of clinical and electroencephalographic seizures with levetiracetam dosing >1000-mg TDD." | 4.31 | Levetiracetam dosing for seizure prophylaxis in neurocritical care patients. ( Ansari, S; Davis, GE; Findlay, MC; Hawryluk, GWJ; Hedges, A; Menacho, ST; Wolfe, BM, 2023) |
| " We compared length of hospital stay (and reported dizziness) in TBI patients receiving the commonest AEDs used in our TBI patients, Phenytoin (which may cause imbalance), and Levetiracetam (which does not affect balance)." | 3.96 | Impact of anti-epileptic drug choice on discharge in acute traumatic brain injury patients. ( Harris, L; Hateley, S; Seemungal, BM; Tsang, KT; Wilson, M, 2020) |
| "There was a small but clinically insignificant difference in the incidence of hyponatremia in traumatic ICH patients receiving levetiracetam vs." | 3.96 | Incidence of hyponatremia in patients given levetiracetam vs. phenytoin for early posttraumatic seizure prophylaxis. ( Bilello, JF; Davis, JW; Dirks, RC; Edmonds, NS; McCullough, KA, 2020) |
| "The primary objective of this study was to determine the effectiveness of a lower dose of levetiracetam (500 mg every 12 hours) to prevent early seizures after traumatic brain injury (TBI)." | 3.83 | Low-dose levetiracetam for seizure prophylaxis after traumatic brain injury. ( Kurita, A; Patanwala, AE; Truong, E, 2016) |
| "In this propensity score-matched cohort analysis, levetiracetam prophylaxis was ineffective in preventing seizures as the rate of seizures was similar whether patients did or did not receive the drug." | 3.83 | Levetiracetam Prophylaxis for Post-traumatic Brain Injury Seizures is Ineffective: A Propensity Score Analysis. ( Friese, R; Gruessner, A; Joseph, B; Khalil, M; Kulvatunyou, N; Latifi, R; O'Keeffe, T; Rhee, P; Wynne, J; Zangbar, B, 2016) |
| "The mean incidence of posttraumatic seizures with AED prophylaxis was 8% for early seizures and 7." | 3.01 | Use of antiepileptic drugs as prophylaxis against posttraumatic seizures in the pediatric population: a systematic review and meta-analysis. ( Al Jayyousi, O; Hazaimeh, E; Ifraitekh, AS; Jbarah, OF; Samara, QA; Sawan, S, 2023) |
| "This review discusses seizures associated with traumatic brain injury in children, including seizure incidence, relationship to severity of injury, potential detrimental effects of seizures, potential benefits of AED, adverse effects of AED, new developments in preventing epileptogenesis, and suggested recommendations for patient management." | 2.53 | Anti-epileptic drugs in pediatric traumatic brain injury. ( Litofsky, NS; Tanaka, T, 2016) |
| "Levetiracetam (LEV) has been proposed as an alternative to PHT." | 2.53 | The safety and efficacy of levetiracetam versus phenytoin for seizure prophylaxis after traumatic brain injury: A systematic review and meta-analysis. ( Li, J; Qi, L; Shao, WZ; Shen, J; Sun, YZ; Tang, LJ; Xu, JC; Zhai, XF; Zheng, JY, 2016) |
| "Phenytoin has been the only recommended antiepileptic drug (AED) for seizure prophylaxis; however, several shortcomings have affected its use." | 2.53 | Levetiracetam Versus Phenytoin for Seizure Prophylaxis Following Traumatic Brain Injury: A Systematic Review and Meta-Analysis. ( Wang, X; Xu, X; Yang, Y; Zheng, F, 2016) |
| "Traumatic brain injury is a major health and socioeconomic problem and the first cause of young death worldwide." | 1.62 | The effect of antiepileptic drugs on re-myelinization of axons: Phenytoin, levetiracetam, carbamazepine, and valproic acid, used following traumatic brain injury. ( Demirci, H; Emmez, H; Gülbahar, Ö; Kuzucu, P; Özişik, P; Seymen, CM, 2021) |
| " Our aim was to translate a recently published comprehensive CNS physiologically-based pharmacokinetic (PBPK) model from rat to human, and to predict drug concentration-time profiles in multiple CNS compartments on available human data of four drugs (acetaminophen, oxycodone, morphine and phenytoin)." | 1.48 | Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach. ( Beukers, MW; Danhof, M; de Lange, ECM; Huntjens, DR; Kokki, H; Kokki, M; Krauwinkel, W; Proost, JH; Välitalo, PA; van Hasselt, JGC; Vermeulen, A; Wong, YC; Yamamoto, Y, 2018) |
| "OBJECTIVE Posttraumatic seizure is a major complication following traumatic brain injury (TBI)." | 1.43 | Variation in seizure prophylaxis in severe pediatric traumatic brain injury. ( Bell, MJ; Boyle, LN; Ellenbogen, RG; Giza, CC; Groner, JI; Kannan, N; Mink, RB; Mitchell, PH; Ostahowski, PJ; Qiu, Q; Vavilala, MS; Wainwright, MS; Zatzick, DF, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 8 (42.11) | 2.80 |
| Authors | Studies |
|---|---|
| Demirci, H | 1 |
| Kuzucu, P | 1 |
| Seymen, CM | 1 |
| Gülbahar, Ö | 1 |
| Özişik, P | 1 |
| Emmez, H | 1 |
| Wang, BC | 1 |
| Chiu, HY | 1 |
| Luh, HT | 1 |
| Lin, CJ | 1 |
| Hsieh, SH | 1 |
| Chen, TJ | 1 |
| Wu, CR | 1 |
| Chen, PY | 1 |
| Vasudevan, V | 1 |
| Amatya, B | 1 |
| Khan, F | 1 |
| Samara, QA | 1 |
| Ifraitekh, AS | 1 |
| Al Jayyousi, O | 1 |
| Sawan, S | 1 |
| Hazaimeh, E | 1 |
| Jbarah, OF | 1 |
| Hedges, A | 1 |
| Findlay, MC | 1 |
| Davis, GE | 1 |
| Wolfe, BM | 1 |
| Hawryluk, GWJ | 1 |
| Menacho, ST | 1 |
| Ansari, S | 1 |
| Harris, L | 1 |
| Hateley, S | 1 |
| Tsang, KT | 1 |
| Wilson, M | 1 |
| Seemungal, BM | 1 |
| Bilello, JF | 1 |
| McCullough, KA | 1 |
| Dirks, RC | 1 |
| Davis, JW | 1 |
| Edmonds, NS | 1 |
| Nguyen, JV | 1 |
| Yaw, T | 1 |
| Gratton, H | 1 |
| Yamamoto, Y | 1 |
| Välitalo, PA | 1 |
| Wong, YC | 1 |
| Huntjens, DR | 1 |
| Proost, JH | 1 |
| Vermeulen, A | 1 |
| Krauwinkel, W | 1 |
| Beukers, MW | 1 |
| Kokki, H | 1 |
| Kokki, M | 1 |
| Danhof, M | 1 |
| van Hasselt, JGC | 1 |
| de Lange, ECM | 1 |
| Wilson, CD | 1 |
| Burks, JD | 1 |
| Rodgers, RB | 1 |
| Evans, RM | 1 |
| Bakare, AA | 1 |
| Safavi-Abbasi, S | 1 |
| Bakr, A | 1 |
| Belli, A | 1 |
| Kwon, SJ | 1 |
| Barletta, JF | 1 |
| Hall, ST | 1 |
| Mangram, AJ | 1 |
| Dzandu, JK | 1 |
| Abdulhamid, M | 1 |
| Zach, V | 1 |
| Patanwala, AE | 1 |
| Kurita, A | 1 |
| Truong, E | 1 |
| Ostahowski, PJ | 1 |
| Kannan, N | 1 |
| Wainwright, MS | 1 |
| Qiu, Q | 1 |
| Mink, RB | 1 |
| Groner, JI | 1 |
| Bell, MJ | 1 |
| Giza, CC | 1 |
| Zatzick, DF | 1 |
| Ellenbogen, RG | 1 |
| Boyle, LN | 1 |
| Mitchell, PH | 1 |
| Vavilala, MS | 1 |
| Tanaka, T | 1 |
| Litofsky, NS | 1 |
| Xu, JC | 1 |
| Shen, J | 1 |
| Shao, WZ | 1 |
| Tang, LJ | 1 |
| Sun, YZ | 1 |
| Zhai, XF | 1 |
| Qi, L | 1 |
| Li, J | 1 |
| Zheng, JY | 1 |
| Zangbar, B | 1 |
| Khalil, M | 1 |
| Gruessner, A | 1 |
| Joseph, B | 1 |
| Friese, R | 1 |
| Kulvatunyou, N | 1 |
| Wynne, J | 1 |
| Latifi, R | 1 |
| Rhee, P | 1 |
| O'Keeffe, T | 1 |
| Yang, Y | 1 |
| Zheng, F | 1 |
| Xu, X | 1 |
| Wang, X | 1 |
| Khan, NR | 1 |
| VanLandingham, MA | 1 |
| Fierst, TM | 1 |
| Hymel, C | 1 |
| Hoes, K | 1 |
| Evans, LT | 1 |
| Mayer, R | 1 |
| Barker, F | 1 |
| Klimo, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pharmacokinetic Analysis of Levetiracetam Prophylaxis in Critically Ill Patients With Severe Traumatic Brain Injury[NCT04836481] | 20 participants (Anticipated) | Observational | 2021-01-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for phenytoin and Encephalopathy, Traumatic
| Article | Year |
|---|---|
Comparative efficacy of prophylactic anticonvulsant drugs following traumatic brain injury: A systematic review and network meta-analysis of randomized controlled trials.
Topics: Anticonvulsants; Brain Injuries, Traumatic; Carbamazepine; Child; Humans; Levetiracetam; Network Met | 2022 |
Overview of systematic reviews: Management of common Traumatic Brain Injury-related complications.
Topics: Brain Injuries, Traumatic; Fatigue; Humans; Levetiracetam; Phenytoin; Seizures; Systematic Reviews a | 2022 |
Use of antiepileptic drugs as prophylaxis against posttraumatic seizures in the pediatric population: a systematic review and meta-analysis.
Topics: Adult; Anticonvulsants; Brain Injuries, Traumatic; Child; Humans; Levetiracetam; Phenytoin; Piraceta | 2023 |
Early and Late Posttraumatic Epilepsy in the Setting of Traumatic Brain Injury: A Meta-analysis and Review of Antiepileptic Management.
Topics: Anticonvulsants; Brain Injuries, Traumatic; Epilepsy, Post-Traumatic; Humans; Levetiracetam; Phenyto | 2018 |
A systematic review of levetiracetam versus phenytoin in the prevention of late post-traumatic seizures and survey of UK neurosurgical prescribing practice of antiepileptic medication in acute traumatic brain injury.
Topics: Adult; Anticonvulsants; Brain Injuries, Traumatic; Cohort Studies; Epilepsy, Post-Traumatic; Female; | 2018 |
Anti-epileptic drugs in pediatric traumatic brain injury.
Topics: Anticonvulsants; Brain Injuries, Traumatic; Child; Humans; Levetiracetam; Phenytoin; Piracetam; Seiz | 2016 |
The safety and efficacy of levetiracetam versus phenytoin for seizure prophylaxis after traumatic brain injury: A systematic review and meta-analysis.
Topics: Anticonvulsants; Brain Injuries, Traumatic; Humans; Levetiracetam; Phenytoin; Piracetam; Seizures | 2016 |
Levetiracetam Versus Phenytoin for Seizure Prophylaxis Following Traumatic Brain Injury: A Systematic Review and Meta-Analysis.
Topics: Anticonvulsants; Brain Injuries, Traumatic; Cohort Studies; Humans; Levetiracetam; Observational Stu | 2016 |
Should Levetiracetam or Phenytoin Be Used for Posttraumatic Seizure Prophylaxis? A Systematic Review of the Literature and Meta-analysis.
Topics: Anticonvulsants; Brain Injuries, Traumatic; Humans; Levetiracetam; Phenytoin; Piracetam; Seizures | 2016 |
10 other studies available for phenytoin and Encephalopathy, Traumatic
| Article | Year |
|---|---|
The effect of antiepileptic drugs on re-myelinization of axons: Phenytoin, levetiracetam, carbamazepine, and valproic acid, used following traumatic brain injury.
Topics: Animals; Anticonvulsants; Axons; Brain Injuries, Traumatic; Carbamazepine; Levetiracetam; Phenytoin; | 2021 |
Levetiracetam dosing for seizure prophylaxis in neurocritical care patients.
Topics: Adult; Anticonvulsants; Brain Injuries, Traumatic; Female; Humans; Levetiracetam; Male; Middle Aged; | 2023 |
Impact of anti-epileptic drug choice on discharge in acute traumatic brain injury patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Injuries, Traumatic; Dizziness; F | 2020 |
Incidence of hyponatremia in patients given levetiracetam vs. phenytoin for early posttraumatic seizure prophylaxis.
Topics: Adult; Anticonvulsants; Brain Injuries, Traumatic; Early Medical Intervention; Female; Humans; Hypon | 2020 |
Incidence of neurobehavioral side effects associated with levetiracetam compared to phenytoin in traumatic brain injury patients.
Topics: Anticonvulsants; Brain Injuries, Traumatic; Humans; Incidence; Levetiracetam; Nervous System Disease | 2021 |
Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach.
Topics: Acetaminophen; Animals; Biological Transport; Brain; Brain Injuries, Traumatic; Central Nervous Syst | 2018 |
Lacosamide versus phenytoin for the prevention of early post traumatic seizures.
Topics: Adult; Aged; Anticonvulsants; Brain Injuries, Traumatic; Drug-Related Side Effects and Adverse React | 2019 |
Low-dose levetiracetam for seizure prophylaxis after traumatic brain injury.
Topics: Adult; Aged; Anticonvulsants; Brain Injuries, Traumatic; Cohort Studies; Dose-Response Relationship, | 2016 |
Variation in seizure prophylaxis in severe pediatric traumatic brain injury.
Topics: Age Factors; Anticonvulsants; Brain; Brain Injuries, Traumatic; Child; Electroencephalography; Femal | 2016 |
Levetiracetam Prophylaxis for Post-traumatic Brain Injury Seizures is Ineffective: A Propensity Score Analysis.
Topics: Adolescent; Adult; Anticonvulsants; Brain Injuries, Traumatic; Chemoprevention; Databases, Factual; | 2016 |