phenytoin has been researched along with Encephalopathy, Toxic in 21 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 44-year-old man with treated neurosyphilis presented with subclinical status epilepticus (SE) refractory to intravenous high-dose lorazepam, phenytoin, and valproic acid over 4 days." | 7.72 | Ketamine for refractory status epilepticus: a case of possible ketamine-induced neurotoxicity. ( Lerner, AJ; Maddux, BN; Sagar, SM; Suarez, JI; Ubogu, EE; Werz, MA, 2003) |
| "We present a case of a 29-year-old female with a history of epilepsy who was admitted for convulsive status epilepticus (CSE), which was controlled by intravenous VPA, as well as oral VPA and phenytoin." | 4.31 | Valproate-related hyperammonemic encephalopathy with generalized suppression EEG: a case report. ( Liu, X; Peng, X, 2023) |
| "The new N-Mannich bases were effective in maximal electroshock or pentylenetetrazole seizures screens; and the most interesting compound 4 (1-{[4-(1-phenyethyl)-piperazin-1-yl]methyl}-3',4'-dihydro-1'H,2H,5H-spiro[imidazolidine-4,2'-naphthalene]-2,5-dione) displayed anticonvulsant activity in both the aforementioned tests." | 3.83 | Design, synthesis, anticonvulsant, and antiarrhythmic properties of novel N-Mannich base and amide derivatives of β-tetralinohydantoin. ( Bednarski, M; Byrtus, H; Czopek, A; Kazek, G; Pawłowski, M; Sapa, J; Siwek, A; Zagórska, A, 2016) |
| " Differentiated human neuroblastoma SH-SY5Y cells were exposed to acrylamide, lindane, parathion, paraoxon, phenytoin, diazepam or caffeine for 72 hours." | 3.74 | Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity. ( Blaauboer, B; Forsby, A, 2007) |
| "A 44-year-old man with treated neurosyphilis presented with subclinical status epilepticus (SE) refractory to intravenous high-dose lorazepam, phenytoin, and valproic acid over 4 days." | 3.72 | Ketamine for refractory status epilepticus: a case of possible ketamine-induced neurotoxicity. ( Lerner, AJ; Maddux, BN; Sagar, SM; Suarez, JI; Ubogu, EE; Werz, MA, 2003) |
| "A 21-year-old white man, with propionic acidemia and seizures treated with phenytoin and carbamazepine, was started on isradipine for essential hypertension." | 3.71 | Phenytoin/isradipine interaction causing severe neurologic toxicity. ( Cachat, F; Tufro, A, 2002) |
| "Phenytoin is an 80-year young molecule and new indications are still emerging." | 2.55 | Phenytoin: neuroprotection or neurotoxicity? ( Keppel Hesselink, JM; Kopsky, DJ, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (66.67) | 29.6817 |
| 2010's | 6 (28.57) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, ZF | 1 |
| Chai, KY | 1 |
| Piao, HR | 1 |
| Kwak, KC | 1 |
| Quan, ZS | 1 |
| Obniska, J | 1 |
| Kaminski, K | 1 |
| Skrzynska, D | 1 |
| Pichor, J | 1 |
| Saravanan, G | 1 |
| Alagarsamy, V | 1 |
| Prakash, CR | 1 |
| Liu, X | 1 |
| Peng, X | 1 |
| Keppel Hesselink, JM | 1 |
| Kopsky, DJ | 1 |
| Czopek, A | 1 |
| Byrtus, H | 1 |
| Zagórska, A | 1 |
| Siwek, A | 1 |
| Kazek, G | 1 |
| Bednarski, M | 1 |
| Sapa, J | 1 |
| Pawłowski, M | 1 |
| Siddiqui, N | 1 |
| Rana, A | 1 |
| Khan, SA | 1 |
| Haque, SE | 1 |
| Alam, MS | 1 |
| Ahsan, W | 1 |
| Ahmed, S | 1 |
| Pasternak, JJ | 1 |
| Lanier, WL | 1 |
| Kesavan, R | 1 |
| Narayan, SK | 1 |
| Adithan, C | 1 |
| Pepe, C | 1 |
| Marchionni, C | 1 |
| Cachat, F | 1 |
| Tufro, A | 1 |
| Hauben, M | 1 |
| Ubogu, EE | 1 |
| Sagar, SM | 1 |
| Lerner, AJ | 1 |
| Maddux, BN | 1 |
| Suarez, JI | 1 |
| Werz, MA | 1 |
| Angehagen, M | 1 |
| Ben-Menachem, E | 1 |
| Rönnbäck, L | 1 |
| Hansson, E | 1 |
| Jessen, K | 1 |
| Kwan, P | 1 |
| Brodie, MJ | 1 |
| Elkiran, ET | 1 |
| Altundag, K | 1 |
| Beyazit, Y | 1 |
| Guler, N | 1 |
| Kars, A | 1 |
| Luszczki, JJ | 1 |
| Antkiewicz-Michaluk, L | 1 |
| Czuczwar, SJ | 1 |
| Llinares-Tello, F | 1 |
| Hernández-Prats, C | 1 |
| Pastor-Climente, I | 1 |
| Escrivá-Moscardó, S | 1 |
| Forsby, A | 1 |
| Blaauboer, B | 1 |
| Rodríguez Gaspar, MA | 1 |
| Martínez Riera, A | 1 |
| González Reimers, E | 1 |
| Santolaria Fernández, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study to Assess the Efficacy of Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy[NCT05019885] | Phase 2 | 6 participants (Anticipated) | Interventional | 2022-08-26 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for phenytoin and Encephalopathy, Toxic
| Article | Year |
|---|---|
Phenytoin: neuroprotection or neurotoxicity?
Topics: Animals; Humans; Neuroprotective Agents; Neurotoxicity Syndromes; Phenytoin | 2017 |
Neuroanesthesiology update.
Topics: Anesthesia; Anesthesiology; Animals; Anticonvulsants; Brain; Calcium Channel Blockers; Electroenceph | 2010 |
Phenobarbital for the treatment of epilepsy in the 21st century: a critical review.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Cost-Benefit Analysis; Developing Countries; Drug Costs; E | 2004 |
18 other studies available for phenytoin and Encephalopathy, Toxic
| Article | Year |
|---|---|
Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Mice; Neurotoxicity Syndromes; Quinolines; Seizure | 2005 |
Synthesis and anticonvulsant activity of new N-[(4-arylpiperazin-1-yl)-alkyl] derivatives of 3-phenyl-pyrrolidine-2,5-dione.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electrosho | 2009 |
Design, synthesis and anticonvulsant activities of novel 1-(substituted/unsubstituted benzylidene)-4-(4-(6,8-dibromo-2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl)phenyl) semicarbazide derivatives.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Design; Neurotoxicity Syndromes; Qu | 2012 |
Valproate-related hyperammonemic encephalopathy with generalized suppression EEG: a case report.
Topics: Adult; Anticonvulsants; Brain Diseases; Electroencephalography; Epilepsy; Female; Humans; Hyperammon | 2023 |
Design, synthesis, anticonvulsant, and antiarrhythmic properties of novel N-Mannich base and amide derivatives of β-tetralinohydantoin.
Topics: Amides; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Disease Models, Animal; Drug Design; Elect | 2016 |
Synthesis of 8-substituted-4-(2/4-substituted phenyl)-2H-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2-thiones and their anticonvulsant, anti-nociceptive, and toxicity evaluation in mice.
Topics: Analgesics; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Liver; Magnetic Resonance Spectr | 2009 |
Influence of CYP2C9 and CYP2C19 genetic polymorphisms on phenytoin-induced neurological toxicity in Indian epileptic patients.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Epilepsy; F | 2010 |
A case of phenytoin-induced encephalopathy in a mathematician with Stage IV NSCLC.
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Neurotoxicity Syndromes; Pheny | 2011 |
Phenytoin/isradipine interaction causing severe neurologic toxicity.
Topics: Acidosis; Adult; Anticonvulsants; Antihypertensive Agents; Calcium Channel Blockers; Drug Interactio | 2002 |
Comment: phenytoin/isradipine interaction causing severe neurologic toxicity.
Topics: Anticonvulsants; Antihypertensive Agents; Drug Interactions; Humans; Isradipine; Neurotoxicity Syndr | 2002 |
Ketamine for refractory status epilepticus: a case of possible ketamine-induced neurotoxicity.
Topics: Adult; Anticonvulsants; Atrophy; Brain; Electroencephalography; Excitatory Amino Acid Antagonists; H | 2003 |
Topiramate protects against glutamate- and kainate-induced neurotoxicity in primary neuronal-astroglial cultures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Astrocytes; Calcium; Calcium Signaling; Cell Membrane; C | 2003 |
Recreational use of phenytoin, marijuana, and alcohol: a case report.
Topics: Adult; Alcoholism; Anticonvulsants; Drug Interactions; Humans; Illicit Drugs; Male; Marijuana Abuse; | 2004 |
Fluorouracil-induced neurotoxicity presenting with generalized tonic-clonic seizure.
Topics: Adenocarcinoma; Anticonvulsants; Antimetabolites, Antineoplastic; Fluorouracil; Humans; Male; Middle | 2004 |
1-Methyl-1,2,3,4-tetrahydroisoquinoline enhances the anticonvulsant action of carbamazepine and valproate in the mouse maximal electroshock seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Dopamine Antagonists; Dyskinesia, Drug-Induced; Electroshoc | 2006 |
[Pharmacokinetic interaction between phenitoin and dexibuprofen resulting in acute neurologic toxicity].
Topics: Aged; Analgesics, Non-Narcotic; Anticonvulsants; Drug Interactions; Female; Humans; Ibuprofen; Neuro | 2007 |
Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity.
Topics: Acrylamide; Animals; Anticonvulsants; Brain Neoplasms; Caffeine; Calcium Channels; Central Nervous S | 2007 |
[Phenytoin neurotoxicity].
Topics: Adolescent; Anticonvulsants; Humans; Male; Middle Aged; Neurotoxicity Syndromes; Phenytoin | 2000 |