phenytoin has been researched along with Drug Refractory Epilepsy in 21 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenytoin is the current standard of care for second-line treatment of paediatric convulsive status epilepticus after failure of first-line benzodiazepines, but is only effective in 60% of cases and is associated with considerable adverse effects." | 9.30 | Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial. ( Babl, FE; Bonisch, M; Borland, ML; Brabyn, C; Cheng, N; Craig, S; Dalziel, SR; Davidson, A; Donath, S; Francis, KL; Furyk, J; George, S; Harvey, AS; Kochar, A; Neutze, J; Oakley, E; Phillips, N; Rao, A; Sharpe, C; Zhang, M, 2019) |
| "Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative." | 9.30 | Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. ( Appleton, RE; Evans, V; Gamble, C; Hickey, H; Humphreys, A; Iyer, A; Lee, ED; Lyttle, MD; Messahel, S; Noblet, J; Potter, S; Rainford, NEA; Roper, L; Tate, P; Woolfall, K, 2019) |
| " This model consists in inducing daily generalized seizures for 23 consecutive days by administration of 3-mercaptopropionic acid (MP)." | 7.85 | New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice. ( Bruno Blanch, L; Castaño, R; Enrique, A; Girardi, E; Goicoechea, S; Orozco, S; Rocha, L; Taborda, F, 2017) |
| "Phenytoin is the current standard of care for second-line treatment of paediatric convulsive status epilepticus after failure of first-line benzodiazepines, but is only effective in 60% of cases and is associated with considerable adverse effects." | 5.30 | Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial. ( Babl, FE; Bonisch, M; Borland, ML; Brabyn, C; Cheng, N; Craig, S; Dalziel, SR; Davidson, A; Donath, S; Francis, KL; Furyk, J; George, S; Harvey, AS; Kochar, A; Neutze, J; Oakley, E; Phillips, N; Rao, A; Sharpe, C; Zhang, M, 2019) |
| "Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative." | 5.30 | Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. ( Appleton, RE; Evans, V; Gamble, C; Hickey, H; Humphreys, A; Iyer, A; Lee, ED; Lyttle, MD; Messahel, S; Noblet, J; Potter, S; Rainford, NEA; Roper, L; Tate, P; Woolfall, K, 2019) |
| "We studied the effect of fosphenytoin (FOS) pre-medication on the incidence and thresholds of after-discharges (ADs), seizures, and functional responses during electrical stimulation mapping (ESM)." | 3.88 | Fosphenytoin pre-medication for pediatric extra-operative electrical stimulation brain mapping. ( Arya, R; Aungaroon, G; Byars, AW; Greiner, HM; Holland, KD; Horn, PS; Mangano, FT; Zea Vera, A, 2018) |
| " This model consists in inducing daily generalized seizures for 23 consecutive days by administration of 3-mercaptopropionic acid (MP)." | 3.85 | New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice. ( Bruno Blanch, L; Castaño, R; Enrique, A; Girardi, E; Goicoechea, S; Orozco, S; Rocha, L; Taborda, F, 2017) |
| " In order to name some, the administration of once-daily dosing of phenytoin or the coadministration of carnitine with valproic acid would be preferable to avoid iatrogenic refractoriness." | 2.82 | The role of efflux transporters and metabolizing enzymes in brain and peripheral organs to explain drug-resistant epilepsy. ( Fagiolino, P; Vázquez, M, 2022) |
| "To identify factors associated with low benzodiazepine (BZD) dosing in patients with refractory status epilepticus (RSE) and to assess the impact of BZD treatment variability on seizure cessation." | 1.56 | First-line medication dosing in pediatric refractory status epilepticus. ( Abend, NS; Amengual-Gual, M; Anderson, A; Arya, R; Brenton, JN; Carpenter, JL; Chapman, K; Clark, J; Farias-Moeller, R; Gaillard, WD; Gaínza-Lein, M; Glauser, T; Goldstein, JL; Goodkin, HP; Guerriero, RM; Kapur, K; Lai, YC; Loddenkemper, T; McDonough, TL; Mikati, MA; Morgan, LA; Novotny, EJ; Ostendorf, AP; Payne, ET; Peariso, K; Piantino, J; Riviello, JJ; Sannagowdara, K; Tasker, RC; Tchapyjnikov, D; Topjian, A; Vasquez, A; Wainwright, MS; Wilfong, A; Williams, K, 2020) |
| "Perampanel (PER) is a new antiepileptic drug (AED) with a novel mechanism of action." | 1.51 | Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy. ( Ishikawa, N; Kobayashi, M; Kobayashi, Y; Tani, H; Tateishi, Y, 2019) |
| " We sought to determine whether there were regions in the dosage range of commonly used AEDs that were associated with superior efficacy in patients with refractory epilepsy." | 1.46 | Association between antiepileptic drug dose and long-term response in patients with refractory epilepsy. ( Castagna, CE; Miller, AB; Poolos, NP; Story, TJ; Williams, S, 2017) |
| "The number of seizure events, severity of seizures, and seizure duration were then compared between the two treatment groups." | 1.42 | Injectable phenytoin loaded polymeric microspheres for the control of temporal lobe epilepsy in rats. ( Bauquier, SH; Chen, Y; Cook, MJ; Halliday, AJ; Jiang, JL; Lai, A; McLean, KJ; Moulton, S; Sui, Y; Wallace, GG; Yue, Z, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (52.38) | 24.3611 |
| 2020's | 10 (47.62) | 2.80 |
| Authors | Studies |
|---|---|
| Vázquez, M | 1 |
| Fagiolino, P | 1 |
| Kesavan, S | 1 |
| Kumar, S | 1 |
| Periyakaruppan, M | 1 |
| Kandasamy, S | 1 |
| Murugesan, G | 1 |
| Liu, Q | 1 |
| Wang, Y | 3 |
| Tan, D | 1 |
| Liu, Y | 2 |
| Zhang, P | 1 |
| Ma, L | 1 |
| Liang, M | 1 |
| Chen, Y | 2 |
| Dang, LT | 1 |
| Quinonez, SC | 1 |
| Becka, BR | 1 |
| Isom, LL | 1 |
| Joshi, SM | 1 |
| Kamate, M | 1 |
| Patil, S | 1 |
| Hossain, M | 1 |
| Williams, S | 2 |
| Ferguson, L | 1 |
| Bingaman, W | 1 |
| Ghosh, A | 1 |
| Najm, IM | 1 |
| Ghosh, C | 1 |
| Vasquez, A | 1 |
| Gaínza-Lein, M | 1 |
| Abend, NS | 1 |
| Amengual-Gual, M | 1 |
| Anderson, A | 1 |
| Arya, R | 2 |
| Brenton, JN | 1 |
| Carpenter, JL | 1 |
| Chapman, K | 1 |
| Clark, J | 1 |
| Farias-Moeller, R | 1 |
| Gaillard, WD | 1 |
| Glauser, T | 1 |
| Goldstein, JL | 1 |
| Goodkin, HP | 1 |
| Guerriero, RM | 1 |
| Kapur, K | 1 |
| Lai, YC | 1 |
| McDonough, TL | 1 |
| Mikati, MA | 1 |
| Morgan, LA | 1 |
| Novotny, EJ | 1 |
| Ostendorf, AP | 1 |
| Payne, ET | 1 |
| Peariso, K | 1 |
| Piantino, J | 1 |
| Riviello, JJ | 1 |
| Sannagowdara, K | 1 |
| Tasker, RC | 1 |
| Tchapyjnikov, D | 1 |
| Topjian, A | 1 |
| Wainwright, MS | 1 |
| Wilfong, A | 1 |
| Williams, K | 1 |
| Loddenkemper, T | 1 |
| Quon, RJ | 1 |
| Meisenhelter, S | 1 |
| Adamovich-Zeitlin, RH | 1 |
| Song, Y | 1 |
| Steimel, SA | 1 |
| Camp, EJ | 1 |
| Testorf, ME | 1 |
| MacKenzie, TA | 1 |
| Gross, RE | 1 |
| Lega, BC | 1 |
| Sperling, MR | 1 |
| Kahana, MJ | 1 |
| Jobst, BC | 1 |
| Wabl, R | 1 |
| Terman, SW | 1 |
| Kwok, M | 1 |
| Elm, J | 1 |
| Chamberlain, J | 1 |
| Silbergleit, R | 1 |
| Hill, CE | 1 |
| Cho, SJ | 1 |
| Park, E | 1 |
| Baker, A | 1 |
| Reid, AY | 1 |
| Ortiz-Madinaveitia, S | 1 |
| Serrano-Madrid, ML | 1 |
| Conejo-Moreno, D | 1 |
| Sagarra-Mur, D | 1 |
| Jimenez-Corral, C | 1 |
| Gutierrez-Alvarez, AM | 1 |
| Aungaroon, G | 1 |
| Zea Vera, A | 1 |
| Horn, PS | 1 |
| Byars, AW | 1 |
| Greiner, HM | 1 |
| Mangano, FT | 1 |
| Holland, KD | 1 |
| Gao, F | 1 |
| Gao, Y | 1 |
| Meng, F | 1 |
| Yang, C | 1 |
| Fu, J | 1 |
| Li, Y | 1 |
| Ishikawa, N | 1 |
| Tateishi, Y | 1 |
| Tani, H | 1 |
| Kobayashi, Y | 1 |
| Kobayashi, M | 1 |
| Dalziel, SR | 1 |
| Borland, ML | 1 |
| Furyk, J | 1 |
| Bonisch, M | 1 |
| Neutze, J | 1 |
| Donath, S | 1 |
| Francis, KL | 1 |
| Sharpe, C | 1 |
| Harvey, AS | 1 |
| Davidson, A | 1 |
| Craig, S | 1 |
| Phillips, N | 1 |
| George, S | 1 |
| Rao, A | 1 |
| Cheng, N | 1 |
| Zhang, M | 1 |
| Kochar, A | 1 |
| Brabyn, C | 1 |
| Oakley, E | 1 |
| Babl, FE | 1 |
| Lyttle, MD | 1 |
| Rainford, NEA | 1 |
| Gamble, C | 1 |
| Messahel, S | 1 |
| Humphreys, A | 1 |
| Hickey, H | 1 |
| Woolfall, K | 1 |
| Roper, L | 1 |
| Noblet, J | 1 |
| Lee, ED | 1 |
| Potter, S | 1 |
| Tate, P | 1 |
| Iyer, A | 1 |
| Evans, V | 1 |
| Appleton, RE | 1 |
| Xu, C | 1 |
| Zhang, S | 1 |
| Nao, J | 1 |
| Ding, F | 1 |
| Zhong, K | 1 |
| Chen, L | 1 |
| Ying, X | 1 |
| Wang, S | 1 |
| Zhou, Y | 1 |
| Duan, S | 1 |
| Chen, Z | 1 |
| Jiang, JL | 1 |
| Yue, Z | 1 |
| Bauquier, SH | 1 |
| Lai, A | 1 |
| McLean, KJ | 1 |
| Halliday, AJ | 1 |
| Sui, Y | 1 |
| Moulton, S | 1 |
| Wallace, GG | 1 |
| Cook, MJ | 1 |
| Enrique, A | 1 |
| Goicoechea, S | 1 |
| Castaño, R | 1 |
| Taborda, F | 1 |
| Rocha, L | 1 |
| Orozco, S | 1 |
| Girardi, E | 1 |
| Bruno Blanch, L | 1 |
| Chi, X | 1 |
| Huang, C | 1 |
| Li, R | 1 |
| Wang, W | 1 |
| Wu, M | 1 |
| Li, J | 1 |
| Zhou, D | 1 |
| Poolos, NP | 1 |
| Castagna, CE | 1 |
| Miller, AB | 1 |
| Story, TJ | 1 |
1 review available for phenytoin and Drug Refractory Epilepsy
| Article | Year |
|---|---|
The role of efflux transporters and metabolizing enzymes in brain and peripheral organs to explain drug-resistant epilepsy.
Topics: Brain; Drug Resistant Epilepsy; Humans; Membrane Transport Proteins; Phenytoin; Valproic Acid | 2022 |
3 trials available for phenytoin and Drug Refractory Epilepsy
| Article | Year |
|---|---|
Efficacy of Home Anticonvulsant Administration for Second-Line Status Epilepticus Treatment.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Comparative Effectiveness Research; Doub | 2021 |
Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial.
Topics: Adolescent; Aged; Anticonvulsants; Australia; Child; Child, Preschool; Drug Administration Schedule; | 2019 |
Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Drug Resistant E | 2019 |
17 other studies available for phenytoin and Drug Refractory Epilepsy
| Article | Year |
|---|---|
Supratherapeutic Phenytoin Therapy in Drug-Refractory Genetic Sodium Channel Epilepsies.
Topics: Anticonvulsants; Drug Resistant Epilepsy; Humans; Phenytoin; Sodium Channels | 2022 |
The Prevention and Reversal of a Phenytoin-Resistant Model by N-acetylcysteine Therapy Involves the Nrf2/P-Glycoprotein Pathway at the Blood-Brain Barrier.
Topics: Acetylcysteine; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; B | 2022 |
Dramatic Improvement in Seizures With Phenytoin Treatment in an Individual With Refractory Epilepsy and a SCN1B Variant.
Topics: Anticonvulsants; Child, Preschool; Drug Resistant Epilepsy; Electroencephalography; Epilepsy, Genera | 2020 |
CAD Deficiency-Another Treatable Early Infantile Epileptic Encephalopathy.
Topics: Anticonvulsants; Aspartate Carbamoyltransferase; Brain Diseases, Metabolic, Inborn; Carbamoyl-Phosph | 2020 |
Heat Shock Proteins Accelerate the Maturation of Brain Endothelial Cell Glucocorticoid Receptor in Focal Human Drug-Resistant Epilepsy.
Topics: Adenosine Triphosphatases; Adolescent; Adult; Aged; ATP Binding Cassette Transporter, Subfamily B; B | 2020 |
First-line medication dosing in pediatric refractory status epilepticus.
Topics: Adolescent; Age Factors; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Dose-Response Re | 2020 |
Factors correlated with intracranial interictal epileptiform discharges in refractory epilepsy.
Topics: Adult; Anticonvulsants; Attention; Carbamazepine; Drug Resistant Epilepsy; Electrocorticography; Fem | 2021 |
Post-Traumatic Epilepsy in Zebrafish Is Drug-Resistant and Impairs Cognitive Function.
Topics: Animals; Anticonvulsants; Carbamazepine; Cognitive Dysfunction; Disease Models, Animal; Drug Resista | 2021 |
[Early onset epileptic encephalopathy in a patient with mutation in
Topics: Age of Onset; Amino Acid Substitution; Anticonvulsants; Child, Preschool; Drug Resistant Epilepsy; D | 2017 |
Fosphenytoin pre-medication for pediatric extra-operative electrical stimulation brain mapping.
Topics: Administration, Intravenous; Brain Mapping; Child; Drug Resistant Epilepsy; Electric Stimulation; El | 2018 |
The Sphingosine 1-Phosphate Analogue FTY720 Alleviates Seizure-induced Overexpression of P-Glycoprotein in Rat Hippocampus.
Topics: Anilides; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cycloox | 2018 |
Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dizziness; Drug Resistant Epile | 2019 |
Subicular pyramidal neurons gate drug resistance in temporal lobe epilepsy.
Topics: Animals; Atrophy; Clozapine; Drug Resistant Epilepsy; Electric Stimulation; Epilepsy, Temporal Lobe; | 2019 |
Injectable phenytoin loaded polymeric microspheres for the control of temporal lobe epilepsy in rats.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Delayed-Action Preparations; Disease Models, Animal; Drug | 2015 |
New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, M | 2017 |
Inhibition of mTOR Pathway by Rapamycin Decreases P-glycoprotein Expression and Spontaneous Seizures in Pharmacoresistant Epilepsy.
Topics: Adult; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Case-Contr | 2017 |
Association between antiepileptic drug dose and long-term response in patients with refractory epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Administration Schedul | 2017 |