phenytoin has been researched along with Down Syndrome in 6 studies
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hyperthyroidism was found in 3/402 (0." | 1.26 | The prevalence of thyroid dysfunction in mentally handicapped in-patients. ( Cameron, J; Goonetilleke, AS; Hughes, VC, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsiouris, JA | 1 |
| Patti, PJ | 1 |
| Tipu, O | 1 |
| Raguthu, S | 1 |
| Hughes, VC | 1 |
| Cameron, J | 1 |
| Goonetilleke, AS | 1 |
| Pavone, L | 1 |
| Mazzone, D | 1 |
| Grasso, S | 1 |
| Prato, F | 1 |
| Raiti, S | 1 |
| Yoshida, M | 1 |
| Kuroda, Y | 1 |
| Yoshida, T | 1 |
| Horiguchi, T | 1 |
| Butterworth, T | 1 |
6 other studies available for phenytoin and Down Syndrome
| Article | Year |
|---|---|
Adverse effects of phenytoin given for late-onset seizures in adults with Down syndrome.
Topics: Adult; Age of Onset; Aged; Anticonvulsants; Down Syndrome; Epilepsy; Female; Humans; Male; Middle Ag | 2002 |
The prevalence of thyroid dysfunction in mentally handicapped in-patients.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cross-Sectional Studies; Down Syndrome; Female; Hu | 1982 |
Diabetes mellitus in a mongoloid child with chronic diphenylhydantoin therapy.
Topics: Child; Diabetes Mellitus, Type 1; Down Syndrome; Epilepsy; Female; Humans; Phenytoin; Risk | 1982 |
Epileptic falling spells after epidural haematoma in adult Down's syndrome.
Topics: Adult; Anticonvulsants; Down Syndrome; Electroencephalography; Epilepsy, Generalized; Functional Lat | 1999 |
[Clinical study on determination of blood thyroid hormone levels using the protein binding test--free thyroxine index in young children].
Topics: Age Factors; Androgens; Antithyroid Agents; Child; Child, Preschool; Down Syndrome; Dwarfism, Pituit | 1971 |
Dermatologic disorders in institutionalized mental defectives.
Topics: Adenoma; Angiomatosis; Antipsychotic Agents; Cheilitis; Dermatitis, Seborrheic; Down Syndrome; Drug | 1971 |