phenytoin and Dizzyness studies

Research Excerpts

Excerpt	Relevance	Reference
" We compared length of hospital stay (and reported dizziness) in TBI patients receiving the commonest AEDs used in our TBI patients, Phenytoin (which may cause imbalance), and Levetiracetam (which does not affect balance)."	3.96	Impact of anti-epileptic drug choice on discharge in acute traumatic brain injury patients. ( Harris, L; Hateley, S; Seemungal, BM; Tsang, KT; Wilson, M, 2020)
"Gabapentin is an anticonvulsant drug that has analgesic properties for acute postoperative pain."	2.74	The analgesic effect of gabapentin as a prophylactic anticonvulsant drug on postcraniotomy pain: a prospective randomized study. ( Aykac, B; Bingol, CA; Karlikaya, G; Sayin, M; Türe, H; Türe, U, 2009)
" The pharmacokinetic assessment was repeated on day 18."	2.69	Lack of pharmacokinetic drug interactions between tiagabine and carbamazepine or phenytoin. ( Boellner, SW; Cao, GX; Cato, A; Guenther, HJ; Gustavson, LE; Qian, JX; Sommerville, KW, 1998)
" Two analyses of adverse events are presented: tolerability and safety."	2.69	Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study. ( Bernstein, P; Faught, RE; Holmes, GL; Magnus-Miller, L; McLean, MJ; Morrell, MJ; Privitera, MD; Rose-Legatt, A; Willmore, LJ, 1999)
"The gabapentin dosage was titrated to effective tolerated dose up to 2400 mg/day."	2.69	Gabapentin as adjunctive therapy for partial seizures. ( Bruni, J, 1999)
"Perampanel (PER) is a new antiepileptic drug (AED) with a novel mechanism of action."	1.51	Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy. ( Ishikawa, N; Kobayashi, M; Kobayashi, Y; Tani, H; Tateishi, Y, 2019)

Research

Studies (12)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

"VAS Score 1: How Much Pain do You Feel in Your Operative Site When Resting?"

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (25.00)	18.7374
1990's	4 (33.33)	18.2507
2000's	2 (16.67)	29.6817
2010's	2 (16.67)	24.3611
2020's	1 (8.33)	2.80

Authors	Studies
Harris, L	1
Hateley, S	1
Tsang, KT	1
Wilson, M	1
Seemungal, BM	1
Ishikawa, N	1
Tateishi, Y	1
Tani, H	1
Kobayashi, Y	1
Kobayashi, M	1
Zappia, CP	1
Piccirillo, B	1
Türe, H	1
Sayin, M	1
Karlikaya, G	1
Bingol, CA	1
Aykac, B	1
Türe, U	1
Soslow, AR	1
Fleishaker, JC	1
Pearson, LK	1
Peters, GR	1
Gustavson, LE	1
Cato, A	1
Boellner, SW	1
Cao, GX	1
Qian, JX	1
Guenther, HJ	1
Sommerville, KW	1
McLean, MJ	1
Morrell, MJ	1
Willmore, LJ	1
Privitera, MD	1
Faught, RE	1
Holmes, GL	1
Magnus-Miller, L	1
Bernstein, P	1
Rose-Legatt, A	1
Bruni, J	1
Pappas, DG	1
Crawford, W	1
Dorn, JM	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903]	Phase 4	77 participants (Actual)	Interventional	2018-05-15	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)

"VAS Score 2: How Much Pain do You Feel in Your Operative Site When Moving?"

Intervention	score on 10-point scale (Mean)
Standard of Care	2.26
Postoperative Gabapentin Regimen	2.46

Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 3: How Well Are You Sleeping?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	3.84
Postoperative Gabapentin Regimen	3.54

Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 4: How Bad is Your Nausea?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	5.73
Postoperative Gabapentin Regimen	6.38

Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 5: How Satisfied Are You With Your Pain Management?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	0.36
Postoperative Gabapentin Regimen	0.17

Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Days Taking Opioids

Intervention	score on a 10-point scale (Mean)
Standard of Care	7.83
Postoperative Gabapentin Regimen	8.48

Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Opioid Consumption

Intervention	days (Mean)
Standard of Care	14.8
Postoperative Gabapentin Regimen	18.7

Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).

Article	Year
The analgesic effect of gabapentin as a prophylactic anticonvulsant drug on postcraniotomy pain: a prospective randomized study. Anesthesia and analgesia, 2009, Volume: 109, Issue:5 Topics: Administration, Oral; Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid;	2009
Induction of tirilazad clearance by phenytoin. Biopharmaceutics & drug disposition, 1998, Volume: 19, Issue:2 Topics: Adult; Anticonvulsants; Antioxidants; Ataxia; Cross-Over Studies; Dizziness; Dose-Response Relations	1998
Lack of pharmacokinetic drug interactions between tiagabine and carbamazepine or phenytoin. American journal of therapeutics, 1998, Volume: 5, Issue:1 Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Dizziness; Drug Interactions; Drug Monitoring; Dr	1998
Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study. Epilepsia, 1999, Volume: 40, Issue:7 Topics: Acetates; Adolescent; Adult; Ambulatory Care; Amines; Anticonvulsants; Asthenia; Carbamazepine; Cycl	1999
Gabapentin as adjunctive therapy for partial seizures. Epilepsia, 1999, Volume: 40 Suppl 6 Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dizziness; Dru	1999

Article	Year
Impact of anti-epileptic drug choice on discharge in acute traumatic brain injury patients. Journal of neurology, 2020, Volume: 267, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Injuries, Traumatic; Dizziness; F	2020
Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy. Epilepsy & behavior : E&B, 2019, Volume: 94 Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dizziness; Drug Resistant Epile	2019
Ataxia and dizziness in a patient on hemodialysis. JAAPA : official journal of the American Academy of Physician Assistants, 2014, Volume: 27, Issue:12 Topics: Anticonvulsants; Ataxia; Dizziness; Humans; Kidney Failure, Chronic; Male; Middle Aged; Phenytoin; R	2014
Psychomotor seizures. Annals of emergency medicine, 1984, Volume: 13, Issue:4 Topics: Abdomen; Adult; Dizziness; Electroencephalography; Epilepsy, Temporal Lobe; Female; Humans; Pain; Ph	1984
Index of suspicion. Pediatrics in review, 2002, Volume: 23, Issue:7 Topics: Adolescent; Anticonvulsants; Ataxia; Cellulitis; Child; Child, Preschool; Creatinine; Diagnosis, Dif	2002
Dizziness due to dysautonomia: response to specific therapy. Southern medical journal, 1988, Volume: 81, Issue:4 Topics: Autonomic Nervous System Diseases; Dizziness; Female; Humans; Middle Aged; Phenytoin	1988
A case of phenytoin toxicity possibly precipitated by trazodone. The Journal of clinical psychiatry, 1986, Volume: 47, Issue:2 Topics: Adult; Dizziness; Drug Interactions; Humans; Male; Phenytoin; Schizophrenia, Paranoid; Seizures; Tra	1986

phenytoin and Dizzyness