phenytoin has been researched along with Disease Models, Animal in 292 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i." | 8.02 | Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021) |
| " Since reepithelization of the cornea is a critical problem, we envisioned that the anticonvulsant phenytoin sodium can promote reepithelization of corneal ulcers as it was repurposed for skin wound healing." | 7.96 | Crown Ether Nanovesicles (Crownsomes) Repositioned Phenytoin for Healing of Corneal Ulcers. ( Afifi, SA; El Sayed, NS; Mahmoud, DB, 2020) |
| " This model consists in inducing daily generalized seizures for 23 consecutive days by administration of 3-mercaptopropionic acid (MP)." | 7.85 | New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice. ( Bruno Blanch, L; Castaño, R; Enrique, A; Girardi, E; Goicoechea, S; Orozco, S; Rocha, L; Taborda, F, 2017) |
| "To identify the possible biological roles of keratinocyte growth factor (KGF), connective tissue growth factor (CTGF) and transforming growth factor-β (TGF-β) in cyclosporine-A (CsA) and phenytoin (PNT)-induced gingival overgrowth (GO) and to correlate them with each other." | 7.83 | Biological roles of KGF, CTGF and TGF-β in cyclosporine-A- and phenytoin- induced gingival overgrowth: A comparative experimental animal study. ( Abdul-Rahman, M; Al-Hamilly, NS; Grawish, ME; Mourad, MI; Radwan, LR, 2016) |
| "Thirty healthy rats were divided into 3 groups, 1) Sham group; 2) Tendon rupture; 3) Tendon rupture+phenytoin (100 mg/kg intraperitoneally) for 21 days." | 7.83 | Phenytoin accelerates tendon healing in a rat model of Achilles tendon rupture. ( Akbari, MG; Ghabili, M; Hajipour, B; Kermani, TA; Laleh, FM; Miyandoab, TM; Mohammad, SA; Mousavi, G; Navali, AM; Roshangar, L; Saleh, BM, 2016) |
| "The present study was focused to evaluate the anticonvulsant effects of phenytoin (PHT) loaded in the silica core of iron oxide nanoparticles (NPs) in an animal model with pharmacoresistant seizures." | 7.81 | Phenytoin carried by silica core iron oxide nanoparticles reduces the expression of pharmacoresistant seizures in rats. ( Garcia Casillas, PE; Luna-Bárcenas, G; Orozco-Suárez, S; Rocha, L; Rosillo-de la Torre, A; Salgado-Ceballos, H; Zurita-Olvera, L, 2015) |
| " Pentylenetetrazole (PTZ)-kindled and spontaneous model of epilepsy (EL) mice were used as models of chemically induced and spontaneous epilepsy, respectively." | 7.80 | Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models. ( Ohtsuki, S; Terasaki, T; Uchida, Y, 2014) |
| "The present study was focused to characterize the effects of intrahippocampal application of R-verapamil, a P-glycoprotein blocker, and High Frequency Electrical Stimulation (HFS) at 130 Hz, on seizure susceptibility and extracellular concentrations of glutamate and γ-aminobutyric acid (GABA) in hippocampus of kindled rats with drug-resistant seizures." | 7.77 | Effects of high frequency electrical stimulation and R-verapamil on seizure susceptibility and glutamate and GABA release in a model of phenytoin-resistant seizures. ( Luna-Munguia, H; Orozco-Suarez, S; Rocha, L, 2011) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 7.76 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " This study tested the hypothesis that sodium channel blockade with phenytoin would result in neuroprotection of retinal ganglion cells (RGCs) and optic nerve axons in an experimental model of glaucoma." | 7.73 | Neuroprotection by sodium channel blockade with phenytoin in an experimental model of glaucoma. ( Hains, BC; Waxman, SG, 2005) |
| "We investigated the effects of valproate (VPA) on an in vivo model of status epilepticus (SE) induced by intrahippocampal application of 4-aminopyridine (4-AP)." | 7.72 | Valproate suppresses status epilepticus induced by 4-aminopyridine in CA1 hippocampus region. ( Martín, ED; Pozo, MA, 2003) |
| "This study evaluated the effectiveness of fosphenytoin as a single or adjunctive anticonvulsant treatment for nerve agent-induced status epilepticus." | 7.72 | Effects of fosphenytoin on nerve agent-induced status epilepticus. ( Benjamin, A; McDonough, JH; McMonagle, JD; Rowland, T; Shih, TM, 2004) |
| "The effects of phenytoin (PHT) and phenobarbital (PHB) on EEG activity and behavior was studied in the model of epilepsy induced by intracerebroventricular (i." | 7.72 | The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats. ( Stanojlovic, O; Stojanovic, J; Susic, V; Zivanovic, D, 2004) |
| "Status epilepticus is usually initially treated with a benzodiazepine such as diazepam." | 7.71 | Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. ( Esmaeil, N; Jones, DM; Macdonald, RL; Maren, S, 2002) |
| " To determine whether phenytoin has a protective effect on axons in a neuroinflammatory model, we studied the effect of phenytoin on axonal degeneration in the optic nerve in MOG-induced experimental allergic encephalomyelitis (EAE)." | 7.71 | Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis. ( Black, JA; Lo, AC; Waxman, SG, 2002) |
| "A potential model for bipolar disorder, quinpirole-induced biphasic locomotion, was used for a preliminary evaluation of behavioral effects of oral anticonvulsant treatment." | 7.71 | Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder. ( Belmaker, RH; Einat, H; Shaldubina, A; Shimon, H; Szechtman, H, 2002) |
| "The efficacy of Flunarizine (FLU), a calcium channel blocker, in combination with conventional antiepileptic drugs, phenytoin (PHT), carbamazepine (CBZ), sodium valproate (VPA), and ethosuximide (ESM), at ED50 doses, were examined for protective effects against maximal electroshock seizures (MES) and pentylenetetrazol (PTZ) induced seizures in mice." | 7.70 | Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice. ( David, J; Joseph, S; Joseph, T, 1998) |
| "To examine the putative seizure-protective properties of felbamate in an animal model of self-sustaining status epilepticus (SSSE)." | 7.70 | Felbamate in experimental model of status epilepticus. ( Baldwin, RA; Mazarati, AM; Sofia, RD; Wasterain, CG, 2000) |
| "The effect of nimodipine alone and in combination with diazepam or phenytoin was tested in the electroshock-induced mouse model of status epilepticus." | 7.70 | Anticonvulsant effect of nimodipine alone and in combination with diazepam and phenytoin in a mouse model of status epilepticus. ( Khosla, P; Pandhi, P, 2000) |
| "These results suggest that magnesium sulfate is a significantly more effective prophylactic agent than phenytoin for N-methyl-D-aspartate-induced seizures." | 7.69 | Magnesium is more efficacious than phenytoin in reducing N-methyl-D-aspartate seizures in rats. ( Bardicef, M; Cotton, DB; Irtenkauf, SM; Mason, BA; Standley, CA, 1994) |
| "We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy." | 7.69 | BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. ( Morimoto, K; Sato, H; Sato, K; Sato, S; Yamada, N, 1997) |
| "Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline." | 7.68 | Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993) |
| " The present experiments compared the noncompetitive N-methyl-D-aspartate antagonists phencyclidine and MK-801 with the anticonvulsant phenytoin in a model of focal brain ischemia." | 7.68 | Comparison of phenytoin with noncompetitive N-methyl-D-aspartate antagonists in a model of focal brain ischemia in rat. ( Boxer, PA; Cordon, JJ; Mann, ME; Marcoux, FW; Rock, DM; Rodolosi, LC; Taylor, CP; Vartanian, MG, 1990) |
| "Heavy male Sprague-Dawley rats die of ventricular fibrillation within 2 to 3 h after isoproterenol administration." | 7.67 | Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death. ( Balazs, T; Ehrreich, SJ; el-Hage, AN; Johnson, GL, 1986) |
| "Doxorubicin (DOX) is an effective anticancer agent, but adverse cardiotoxic effects limit its use." | 5.43 | Cardioprotective Effect of Phenytoin on Doxorubicin-induced Cardiac Toxicity in a Rat Model. ( Asadnasab, G; Ashrafi Helan, J; Azarmi, Y; Babaei, H; Mohajjel Nayebi, A; Razmaraii, N, 2016) |
| "When fully kindled seizures were achieved by daily electrical stimulation of the amygdala, rats were randomly divided into three groups: control, phenytoin, and phenytoin (PHT)+5'-N-ethylcarboxamidoadenosine (NECA) groups." | 5.42 | Activation of adenosine receptor potentiates the anticonvulsant effect of phenytoin against amygdala kindled seizures. ( Sun, Z; Tan, L; Wu, ZC; Yu, JT; Zhang, Q; Zhong, XL; Zong, Y, 2015) |
| "The present study was aimed to characterize the anticonvulsant effects of piperine in combination with well established antiepileptic drug (AED) phenytoin, in the mouse maximal electroshock (MES)-induced seizure model by using the type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs)." | 5.39 | Combination therapy of piperine and phenytoin in maximal electroshock induced seizures in mice: isobolographic and biochemical analysis. ( Khanam, R; Pillai, KK; Saraogi, P; Vohora, D, 2013) |
| "Curcumin was co-administered with sub-therapeutic dose of valproate 60min before PTZ injection." | 5.37 | Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. ( Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH, 2011) |
| "ADD and seizure severity were also measured in response to both threshold and suprathreshold kindling stimulation." | 5.31 | Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of acute phenytoin. ( Bharadia, V; Gilbert, TH; Teskey, GC, 2001) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 5.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| "Evidence has been presented that there is a quantitative variation of fetal palatal glucocorticoid receptor levels which correlates with susceptibility to cortisone-induced cleft palate in a variety of inbred strains of mice." | 4.76 | Quantitative variation in hormonal receptors and clefting in the mouse. ( Goldman, AS; Katsumata, M, 1980) |
| " This study was aimed at determining the influence of isopimpinellin (ISOP-a coumarin) when administered either separately or in combination with borneol (BOR-a monoterpenoid), on the antiseizure potencies of four classic ASMs (carbamazepine (CBZ), phenytoin (PHT), phenobarbital (PB), and valproate (VPA)) in the mouse model of maximal electroshock-induced (MES) tonic-clonic seizures." | 4.31 | Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic-clonic seizure model: an isobolographic transformation. ( Bojar, H; Chmielewski, J; Florek-Łuszczki, M; Jankiewicz, K; Skalicka-Woźniak, K; Łuszczki, JJ, 2023) |
| " In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i." | 4.02 | Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021) |
| " In this study, we examined the effect of both acute and chronic treatment with moclobemide on seizures and the action of first-generation antiepileptic drugs: valproate, carbamazepine, phenobarbital and phenytoin." | 4.02 | Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice. ( Banach, M; Borowicz-Reutt, KK, 2021) |
| " Since reepithelization of the cornea is a critical problem, we envisioned that the anticonvulsant phenytoin sodium can promote reepithelization of corneal ulcers as it was repurposed for skin wound healing." | 3.96 | Crown Ether Nanovesicles (Crownsomes) Repositioned Phenytoin for Healing of Corneal Ulcers. ( Afifi, SA; El Sayed, NS; Mahmoud, DB, 2020) |
| " Pentylenetetrazole- (PTZ) and pilocarpine-induced seizures are well-established models of human epilepsy." | 3.91 | The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure. ( Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Rezaeian-Varmaziar, H; Shafaat, O, 2019) |
| " The aim of the present study was to explore the effect of a selective CB2 receptor agonist β-caryophyllene (BCP) in models of seizures and cognition in mice." | 3.88 | Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice. ( da Conceição Machado, K; de Carvalho Melo Cavalcante, AA; Gomes Júnior, AL; Momchilova, A; Tchekalarova, J; Tzoneva, R, 2018) |
| ", phenobarbital [PB], phenytoin [PHT] and pregabalin [PGB]) at the fixed-ratio of 1:1:1, we used a model of tonic-clonic seizures in male albino Swiss mice." | 3.88 | Combination of phenobarbital with phenytoin and pregabalin produces synergy in the mouse tonic-clonic seizure model: An isobolographic analysis. ( Florek-Luszczki, M; Luszczki, JJ; Mazurkiewicz, LP; Ossowska, G; Szpringer, M; Wlaz, A; Wroblewska-Luczka, P; Zolkowska, D, 2018) |
| "Sotalol as a drug blocking β-receptors and potassium KCNH2 channels may interact with different substances that affect seizures." | 3.85 | Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model. ( Banach, M; Borowicz-Reutt, KK; Popławska, M, 2017) |
| " This model consists in inducing daily generalized seizures for 23 consecutive days by administration of 3-mercaptopropionic acid (MP)." | 3.85 | New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice. ( Bruno Blanch, L; Castaño, R; Enrique, A; Girardi, E; Goicoechea, S; Orozco, S; Rocha, L; Taborda, F, 2017) |
| "To identify the possible biological roles of keratinocyte growth factor (KGF), connective tissue growth factor (CTGF) and transforming growth factor-β (TGF-β) in cyclosporine-A (CsA) and phenytoin (PNT)-induced gingival overgrowth (GO) and to correlate them with each other." | 3.83 | Biological roles of KGF, CTGF and TGF-β in cyclosporine-A- and phenytoin- induced gingival overgrowth: A comparative experimental animal study. ( Abdul-Rahman, M; Al-Hamilly, NS; Grawish, ME; Mourad, MI; Radwan, LR, 2016) |
| "The new N-Mannich bases were effective in maximal electroshock or pentylenetetrazole seizures screens; and the most interesting compound 4 (1-{[4-(1-phenyethyl)-piperazin-1-yl]methyl}-3',4'-dihydro-1'H,2H,5H-spiro[imidazolidine-4,2'-naphthalene]-2,5-dione) displayed anticonvulsant activity in both the aforementioned tests." | 3.83 | Design, synthesis, anticonvulsant, and antiarrhythmic properties of novel N-Mannich base and amide derivatives of β-tetralinohydantoin. ( Bednarski, M; Byrtus, H; Czopek, A; Kazek, G; Pawłowski, M; Sapa, J; Siwek, A; Zagórska, A, 2016) |
| "Thirty healthy rats were divided into 3 groups, 1) Sham group; 2) Tendon rupture; 3) Tendon rupture+phenytoin (100 mg/kg intraperitoneally) for 21 days." | 3.83 | Phenytoin accelerates tendon healing in a rat model of Achilles tendon rupture. ( Akbari, MG; Ghabili, M; Hajipour, B; Kermani, TA; Laleh, FM; Miyandoab, TM; Mohammad, SA; Mousavi, G; Navali, AM; Roshangar, L; Saleh, BM, 2016) |
| "The role of zinc in seizure models and with antiepileptic drugs sodium valproate (SV) and phenytoin (PHT) was studied using experimental models of seizures in rats." | 3.81 | Low dose zinc supplementation beneficially affects seizure development in experimental seizure models in rats. ( Gupta, YK; Katyal, J; Kumar, H, 2015) |
| " We evaluated influence of DHA on anticonvulsant activity of AEDs phenytoin, valproate, and lamotrigine in maximal electroshock (MES), pentylenetetrazole (PTZ), and kindling models of epilepsy." | 3.81 | Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. ( Babapour, V; Gavzan, H; Sardari, S; Sayyah, M, 2015) |
| " Diazepam produced a dose-dependent protection against 6-Hz seizures in control and pilocarpine mice, both at 2 weeks and 8 weeks after SE, but with a more pronounced increase in potency in post-SE animals at 2 weeks." | 3.81 | Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model. ( Kaminski, RM; Leclercq, K, 2015) |
| " Thirty mice that developed seizures were randomly divided into three groups and administered PHT as well as the following treatments: saline (negative control); verapamil (20 mg/kg, positive control); and G." | 3.81 | Reversal of P-glycoprotein overexpression by Ginkgo biloba extract in the brains of pentylenetetrazole-kindled and phenytoin-treated mice. ( Chen, SL; Fan, Q; Ma, H; Zhang, C, 2015) |
| "The present study was focused to evaluate the anticonvulsant effects of phenytoin (PHT) loaded in the silica core of iron oxide nanoparticles (NPs) in an animal model with pharmacoresistant seizures." | 3.81 | Phenytoin carried by silica core iron oxide nanoparticles reduces the expression of pharmacoresistant seizures in rats. ( Garcia Casillas, PE; Luna-Bárcenas, G; Orozco-Suárez, S; Rocha, L; Rosillo-de la Torre, A; Salgado-Ceballos, H; Zurita-Olvera, L, 2015) |
| " Pentylenetetrazole (PTZ)-kindled and spontaneous model of epilepsy (EL) mice were used as models of chemically induced and spontaneous epilepsy, respectively." | 3.80 | Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models. ( Ohtsuki, S; Terasaki, T; Uchida, Y, 2014) |
| " We tested the hypothesis that status epilepticus (SE) or exposure to phenytoin or phenobarbital affects brain expression of the metabolic enzyme CYP2E1." | 3.80 | Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression. ( Boussadia, B; de Bock, F; Ghosh, C; Janigro, D; Marchi, N; Pascussi, JM; Plaud, C; Rousset, MC, 2014) |
| " Initial anticonvulsant screening was performed in mice (ip) using the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) seizures tests." | 3.79 | Design, synthesis and anticonvulsant properties of new N-Mannich bases derived from 3-phenylpyrrolidine-2,5-diones. ( Chlebek, I; Kamiński, K; Obniska, J; Rzepka, S; Wiklik, B, 2013) |
| "Single intraperitoneal (ip) administration of CYT in a subthreshold dose of 2 mg/kg antagonized the protective activity of ip phenytoin and lamotrigine against MES-induced seizures in mice." | 3.79 | Cytisine inhibits the anticonvulsant activity of phenytoin and lamotrigine in mice. ( Bednarski, J; Mosiewicz, J; Mróz, T; Ognik, J; Styk, A; Tutka, P; Łuszczki, J, 2013) |
| " Our data have demonstrated that pentylenetetrazole (PTZ)-induced seizures did not alter ATP, ADP, and AMP hydrolysis in brain membrane fractions." | 3.79 | Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish. ( Bogo, MR; Bonan, CD; Nery, LR; Piato, AL; Schaefer, IC; Siebel, AM, 2013) |
| "The number of animals with seizures was lower in the etomidate (60%), phenytoin (40%), and phenytoin/midazolam (40%) groups (P<0." | 3.78 | Effects of pretreatment with etomidate, ketamine, phenytoin, and phenytoin/midazolam on acute, lethal cocaine toxicity. ( Degirmenci, E; Erdur, B; Ergin, A; Kortunay, S; Seyit, M; Yuksel, A, 2012) |
| "The present study was focused to characterize the effects of intrahippocampal application of R-verapamil, a P-glycoprotein blocker, and High Frequency Electrical Stimulation (HFS) at 130 Hz, on seizure susceptibility and extracellular concentrations of glutamate and γ-aminobutyric acid (GABA) in hippocampus of kindled rats with drug-resistant seizures." | 3.77 | Effects of high frequency electrical stimulation and R-verapamil on seizure susceptibility and glutamate and GABA release in a model of phenytoin-resistant seizures. ( Luna-Munguia, H; Orozco-Suarez, S; Rocha, L, 2011) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 3.76 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| "Preliminary clinical trials have recently shown that phenytoin, an antiepileptic drug, may also be beneficial for treatment of bipolar disorder." | 3.76 | Effect of prolonged phenytoin administration on rat brain gene expression assessed by DNA microarrays. ( Agam, G; Amar, S; Belmaker, RH; Conte, A; Mariotti, V; Melissari, E; Pellegrini, S, 2010) |
| "2 s, while chemical seizures were induced by intraperitoneal injection of pentylenetetrazole at its CD97 dose (97% convulsive dose for the clonic phase)." | 3.76 | Influence of etoricoxib on anticonvulsant activity of phenytoin and diazepam in experimental seizure models in mice. ( Anitha, T; Gajera, K; Jayaraman, R; Joshi, VD; Ladani, K; Manisenthil, KT; Palei, NN, 2010) |
| " Some selected compounds were assayed against seizures induced by pentylenetetrazole (PTZ) and strychnine in mice." | 3.74 | Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents. ( Al-Eryani, YA; Amin, KM; Rahman, DE, 2008) |
| "The present work was undertaken to examine the central pharmacokinetics of phenytoin (PHT) in an experimental model of epilepsy, induced by administration of 3-mercaptopropionic acid (MP), and possible participation of P-glycoprotein in this model of epilepsy." | 3.74 | Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model. ( Auzmendi, J; Bramuglia, GF; Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Opezzo, JA; Taira, CA, 2007) |
| "In the present study we examined if rats with PB-resistant seizures are also resistant to phenytoin (PHT), using continuous EEG/video recording of spontaneous seizures." | 3.74 | Resistance to phenobarbital extends to phenytoin in a rat model of temporal lobe epilepsy. ( Bethmann, K; Brandt, C; Löscher, W, 2007) |
| "Using the mouse maximal electroshock-induced seizure model, indicative of tonic-clonic seizures in humans, the present study was aimed at characterizing the interaction between remacemide and valproate, carbamazepine, phenytoin, and phenobarbital." | 3.74 | Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ; Malek, R; Patsalos, PN; Ratnaraj, N, 2007) |
| "Oral rufinamide suppressed pentylenetetrazol-induced seizures in mice (ED(50) 45." | 3.74 | The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. ( Franklin, MR; Kupferberg, HJ; Schmutz, M; Stables, JP; White, HS; Wolf, HH, 2008) |
| " In this study the anticonvulsant actions of norfluoxetine and fluoxetine were studied and compared to those of phenytoin and clonazepam in pentylenetetrazol-induced mouse epilepsy models." | 3.73 | Norfluoxetine and fluoxetine have similar anticonvulsant and Ca2+ channel blocking potencies. ( Harasztosi, C; Kecskeméti, V; Nánási, PP; Pál, B; Riba, P; Rusznák, Z; Szûcs, G; Wagner, R, 2005) |
| " This study tested the hypothesis that sodium channel blockade with phenytoin would result in neuroprotection of retinal ganglion cells (RGCs) and optic nerve axons in an experimental model of glaucoma." | 3.73 | Neuroprotection by sodium channel blockade with phenytoin in an experimental model of glaucoma. ( Hains, BC; Waxman, SG, 2005) |
| "0 mg/kg) as well as increasing the threshold to electrically- and pentylenetetrazole-induced seizures (TID(10)s 7." | 3.73 | In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant. ( Anderson, NJ; Slough, S; Watson, WP, 2006) |
| " In this study, we asked whether phenytoin, which is known to block sodium channels, can protect spinal cord axons from degeneration in mice with experimental allergic encephalomyelitis (EAE), which display substantial axonal degeneration and clinical paralysis." | 3.72 | Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivo. ( Black, JA; Lo, AC; Saab, CY; Waxman, SG, 2003) |
| "We investigated the effects of valproate (VPA) on an in vivo model of status epilepticus (SE) induced by intrahippocampal application of 4-aminopyridine (4-AP)." | 3.72 | Valproate suppresses status epilepticus induced by 4-aminopyridine in CA1 hippocampus region. ( Martín, ED; Pozo, MA, 2003) |
| "This study evaluated the effectiveness of fosphenytoin as a single or adjunctive anticonvulsant treatment for nerve agent-induced status epilepticus." | 3.72 | Effects of fosphenytoin on nerve agent-induced status epilepticus. ( Benjamin, A; McDonough, JH; McMonagle, JD; Rowland, T; Shih, TM, 2004) |
| "The effects of phenytoin (PHT) and phenobarbital (PHB) on EEG activity and behavior was studied in the model of epilepsy induced by intracerebroventricular (i." | 3.72 | The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats. ( Stanojlovic, O; Stojanovic, J; Susic, V; Zivanovic, D, 2004) |
| "The nootropic drug piracetam was investigated in various experimental models of epilepsy." | 3.72 | Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models. ( De Sarro, G; Fischer, W; Kittner, H; Regenthal, R; Russo, E, 2004) |
| "Status epilepticus is usually initially treated with a benzodiazepine such as diazepam." | 3.71 | Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. ( Esmaeil, N; Jones, DM; Macdonald, RL; Maren, S, 2002) |
| " To determine whether phenytoin has a protective effect on axons in a neuroinflammatory model, we studied the effect of phenytoin on axonal degeneration in the optic nerve in MOG-induced experimental allergic encephalomyelitis (EAE)." | 3.71 | Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis. ( Black, JA; Lo, AC; Waxman, SG, 2002) |
| "A potential model for bipolar disorder, quinpirole-induced biphasic locomotion, was used for a preliminary evaluation of behavioral effects of oral anticonvulsant treatment." | 3.71 | Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder. ( Belmaker, RH; Einat, H; Shaldubina, A; Shimon, H; Szechtman, H, 2002) |
| "The efficacy of Flunarizine (FLU), a calcium channel blocker, in combination with conventional antiepileptic drugs, phenytoin (PHT), carbamazepine (CBZ), sodium valproate (VPA), and ethosuximide (ESM), at ED50 doses, were examined for protective effects against maximal electroshock seizures (MES) and pentylenetetrazol (PTZ) induced seizures in mice." | 3.70 | Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice. ( David, J; Joseph, S; Joseph, T, 1998) |
| " In a thromboplastin-induced thromboembolism model, administration of 30 mg/kg YM-75466 or 3 mg/kg warfarin significantly improved the lethality ratio." | 3.70 | Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice. ( Hirayama, F; Iizumi, Y; Kawasaki, T; Koshio, H; Matsumoto, Y; Sato, K; Taniuchi, Y, 1998) |
| "To examine the putative seizure-protective properties of felbamate in an animal model of self-sustaining status epilepticus (SSSE)." | 3.70 | Felbamate in experimental model of status epilepticus. ( Baldwin, RA; Mazarati, AM; Sofia, RD; Wasterain, CG, 2000) |
| " In PHT nonresponders, TPM significantly increased ADT, which is in line with its proven efficacy in patients with refractory partial epilepsy in whom phenytoin has failed." | 3.70 | Anticonvulsant efficacy of topiramate in phenytoin-resistant kindled rats. ( Ebert, U; Löscher, W; Reissmüller, E, 2000) |
| "The effect of nimodipine alone and in combination with diazepam or phenytoin was tested in the electroshock-induced mouse model of status epilepticus." | 3.70 | Anticonvulsant effect of nimodipine alone and in combination with diazepam and phenytoin in a mouse model of status epilepticus. ( Khosla, P; Pandhi, P, 2000) |
| "These results suggest that magnesium sulfate is a significantly more effective prophylactic agent than phenytoin for N-methyl-D-aspartate-induced seizures." | 3.69 | Magnesium is more efficacious than phenytoin in reducing N-methyl-D-aspartate seizures in rats. ( Bardicef, M; Cotton, DB; Irtenkauf, SM; Mason, BA; Standley, CA, 1994) |
| "We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures." | 3.69 | Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1997) |
| "We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy." | 3.69 | BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. ( Morimoto, K; Sato, H; Sato, K; Sato, S; Yamada, N, 1997) |
| "Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline." | 3.68 | Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993) |
| " The present experiments compared the noncompetitive N-methyl-D-aspartate antagonists phencyclidine and MK-801 with the anticonvulsant phenytoin in a model of focal brain ischemia." | 3.68 | Comparison of phenytoin with noncompetitive N-methyl-D-aspartate antagonists in a model of focal brain ischemia in rat. ( Boxer, PA; Cordon, JJ; Mann, ME; Marcoux, FW; Rock, DM; Rodolosi, LC; Taylor, CP; Vartanian, MG, 1990) |
| " The compounds were screened in mice for their ability to antagonize maximal electroshock- and bicuculline-induced seizures; neurotoxicity was evaluated in the rotorod test." | 3.67 | Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy. ( Biziere, K; Brochard, J; Brodin, R; Chambon, JP; Hallot, A; Merlier, J, 1986) |
| "The anticonvulsant effect of either phenobarbital or dilantin was potentiated by exogenous glycine in DBA/2 audiogenic seizure mice and in 3-mercaptopropionic acid-induced seizures." | 3.67 | Glycine potentiates the action of some anticonvulsant drugs in some seizure models. ( Lajtha, A; Toth, E, 1984) |
| " The anticonvulsant effect was seizure-specific; thus, U50,488 protected against supramaximal electroshock seizures but failed to raise the threshold of flurothyl-induced convulsions." | 3.67 | U50,488, a highly selective kappa opioid: anticonvulsant profile in rats. ( Holaday, JW; Robles, L; Tortella, FC, 1986) |
| "Heavy male Sprague-Dawley rats die of ventricular fibrillation within 2 to 3 h after isoproterenol administration." | 3.67 | Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death. ( Balazs, T; Ehrreich, SJ; el-Hage, AN; Johnson, GL, 1986) |
| "Senegalese baboons (Papio papio), with a natural syndrome of photosensitive epilepsy, consistently show generalized myoclonic jerks if stimulated stroboscopically at hourly intervals, two to eight hours after the intravenous administration of allylglycine, 200 mg/kg." | 3.65 | A primate model for testing anticonvulsant drugs. ( Horton, RW; Meldrum, BS; Toseland, PA, 1975) |
| " To test the validity of this primate model, the effects of diphenylhydantoin (DPH), phenobarbital, and primidone on spontaneous seizures evaluated for 8 months with a Latin-Squar experimental design." | 3.65 | Efficacy of standard anticonvulsants in monkey model with spontaneous motor seizures. ( DuCharme, LL; Farquhar, JA; Huntsman, BJ; Lockard, JS; Uhlir, V, 1975) |
| "Current treatment of human status epilepticus (SE) relies on drugs developed for chronic treatment of epilepsy." | 2.76 | Canine status epilepticus: a translational platform for human therapeutic trials. ( Cloyd, JC; Coles, LD; Craft, EM; Leppik, IE; Patterson, EN, 2011) |
| "Epilepsy affects fetal brain development during gestation in pregnant rats, therefore anti-epileptic therapy should be continued during pregnancy." | 2.53 | Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats. ( Doğan, Z; Kamışlı, Ö; Soysal, H, 2016) |
| "We have chosen to study the role of genetic susceptibility to teratogen-induced orofacial clefting, using 2 drugs (dilantin and corticosteroid) and 1 nondrug teratogen (6-aminonicotinamide)." | 2.46 | Genes, environment, and orofacial clefting: N-acetyltransferase and folic acid. ( Erickson, RP, 2010) |
| "Oxcarbazepine (OXC) was developed to provide a compound chemically similar enough to CBZ to mimic its efficacy and overall safety while improving its side-effect profile." | 2.40 | Oxcarbazepine. ( Tecoma, ES, 1999) |
| "Since arrhythmia often accompanies seizures, patients suffering from epilepsy are frequently co-treated with antiepileptic and antiarrhythmic drugs." | 1.72 | Ranolazine Interacts Antagonistically with Some Classical Antiepileptic Drugs-An Isobolographic Analysis. ( Banach, M; Borowicz-Reutt, K, 2022) |
| " Similar dose-related responses were seen following the week-long dosing protocol for carbamazepine, phenobarbital, and phenytoin, and these responses were associated with drug levels that were in the human therapeutic range." | 1.62 | Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency. ( Bertram, EH; Edelbroek, P, 2021) |
| "Propofol was effective, exhibiting high efficacy and potency for terminating seizure activity quickly in pediatric and adult animals, suggesting it may be an effective anticonvulsant for NA-induced seizures in pediatric populations." | 1.56 | Evaluation of fosphenytoin, levetiracetam, and propofol as treatments for nerve agent-induced seizures in pediatric and adult rats. ( Ardinger, CE; Berger, KE; Dunn, EN; Haines, KM; Jackson Piercy, CE; Lee-Stubbs, RB; Matson, LM; McCarren, HS; McDonough, JH; Miller-Smith, SM; Whitten, KA, 2020) |
| "Electrically-induced tonic-clonic seizures were experimentally evoked in adult male albino Swiss mice." | 1.51 | New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure model. ( Gut-Lepiech, A; Karwan, S; Kondrat-Wróbel, MW; Marzeda, P; Plech, T; Wróblewska-Łuczka, P; Łuszczki, JJ, 2019) |
| "Phenytoin 1% ointment was used as a standard control." | 1.48 | Wound healing property of milk in full thickness wound model of rabbit. ( Hemmati, AA; Housmand, G; Jalali, A; Larki-Harchegani, A; Rezaei, A; Shabib, S, 2018) |
| "Cunaniol-induced seizures displayed a cyclic development of electrocorticographic seizures, presenting interictal-like spike and ictal period, which correlates to the behavioral observations and is in line with acute seizures induced by pentylenetetrazole." | 1.48 | Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses. ( Barbas, LAL; de Mello, VJ; do Nascimento, JLM; Dos Santos Batista, L; Dos Santos Batista, P; Farias, RAF; Gomes-Leal, W; Hamoy, M; Hutchison, WD; Marcondes, HC; Taylor, JG; Torres, MF, 2018) |
| "Treatment with phenytoin per se and along with the flavonoid rich fraction showed significant reduction in seizure severity score as compared to vehicle control." | 1.43 | Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: A repertoire of Glycyrrhiza glabra flavonoid antioxidants. ( Goel, RK; Singh, D; Singh, P, 2016) |
| " Therefore, H3Rs may have implications for the treatment of degenerative disorders associated with impaired memory function and may represent a novel therapeutic pharmacological target to tackle cognitive problems associated with the chronic use of antiepileptic drugs." | 1.43 | Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats. ( Kieć-Kononowiczc, K; Saad, A; Sadek, B; Shafiullah, M; Subramanian, D; Łażewska, D, 2016) |
| "Doxorubicin (DOX) is an effective anticancer agent, but adverse cardiotoxic effects limit its use." | 1.43 | Cardioprotective Effect of Phenytoin on Doxorubicin-induced Cardiac Toxicity in a Rat Model. ( Asadnasab, G; Ashrafi Helan, J; Azarmi, Y; Babaei, H; Mohajjel Nayebi, A; Razmaraii, N, 2016) |
| "When fully kindled seizures were achieved by daily electrical stimulation of the amygdala, rats were randomly divided into three groups: control, phenytoin, and phenytoin (PHT)+5'-N-ethylcarboxamidoadenosine (NECA) groups." | 1.42 | Activation of adenosine receptor potentiates the anticonvulsant effect of phenytoin against amygdala kindled seizures. ( Sun, Z; Tan, L; Wu, ZC; Yu, JT; Zhang, Q; Zhong, XL; Zong, Y, 2015) |
| "Pre-clinical trial of abbreviated LEV dosing in an experimental model of TBI Methods: After either controlled cortical impact (CCI) injury or sham surgery, rats received three 50 mg kg(-1) doses over 24 hours or vehicle." | 1.42 | Abbreviated levetiracetam treatment effects on behavioural and histological outcomes after experimental TBI. ( Fowler, L; Hurwitz, M; Wagner, AK; Zou, H, 2015) |
| "In a first step, we examined anti-seizure effects of 6 AEDs on spontaneous recurrent focal electrographic seizures and secondarily generalized convulsive seizures in epileptic mice, showing that the focal nonconvulsive seizures were resistant to carbamazepine and phenytoin, whereas valproate and levetiracetam exerted moderate and phenobarbital and diazepam marked anti-seizure effects." | 1.42 | Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice. ( Bankstahl, M; Klein, S; Löscher, W, 2015) |
| " Dose-response curves for phenytoin and levetiracetam were generated in the three strains at 32 and 44 mA current intensities using both devices." | 1.42 | Genetic background of mice strongly influences treatment resistance in the 6 Hz seizure model. ( Kaminski, RM; Leclercq, K, 2015) |
| "Treatment with phenytoin, at a dose equivalent to that used to treat epilepsy (60 mg/kg; daily), significantly reduced tumour growth, without affecting animal weight." | 1.42 | The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. ( Brackenbury, WJ; Dowle, AA; Nelson, M; Thomas, JR; Yang, M, 2015) |
| " Chronic dosing of propranolol may be required for efficacy; therefore, we tested the efficacy of chronic treatment with either propranolol or phenytoin on RTT mice." | 1.42 | Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs. ( Glaze, DG; Herrera, JA; Kaufmann, WE; Neul, JL; Percy, AK; Pitcher, MR; Skinner, S; Ward, CS; Wehrens, XH, 2015) |
| "Focal electrographic seizures in this model are resistant to several major antiepileptic drugs." | 1.42 | The AMPA receptor antagonist NBQX exerts anti-seizure but not antiepileptogenic effects in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy. ( Bankstahl, M; Klein, S; Löscher, W; Römermann, K; Twele, F, 2015) |
| "Treatment-resistant seizures affect about a third of patients suffering from epilepsy." | 1.42 | Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish. ( Afrikanova, T; Buenafe, OE; Crawford, AD; De Prins, A; de Witte, PA; Esguerra, CV; Kaminski, RM; Langlois, M; Leclercq, K; Rospo, CC; Smolders, I; Van Eeckhaut, A, 2015) |
| "We utilized a middle cerebral artery occlusion model and examined seizure activity and brain injury using combined behavioral and electroencephalographic monitoring and histological assessments." | 1.42 | Modeling early-onset post-ischemic seizures in aging mice. ( Aljarallah, S; Eubanks, JH; Gao, X; Huang, Y; McDonald, R; Patel, N; Peng, J; Wang, J; Wu, C; Zhang, L, 2015) |
| "Seizures were induced by single application of a current intensity of 49 mA to i." | 1.42 | Validation of the 6 Hz refractory seizure mouse model for intracerebroventricularly administered compounds. ( Bentea, E; Coppens, J; Maes, K; Massie, A; Smolders, I; Van Eeckhaut, A; Van Liefferinge, J; Walrave, L, 2015) |
| "The number of seizure events, severity of seizures, and seizure duration were then compared between the two treatment groups." | 1.42 | Injectable phenytoin loaded polymeric microspheres for the control of temporal lobe epilepsy in rats. ( Bauquier, SH; Chen, Y; Cook, MJ; Halliday, AJ; Jiang, JL; Lai, A; McLean, KJ; Moulton, S; Sui, Y; Wallace, GG; Yue, Z, 2015) |
| "With either etiology, seizures are a poor prognostic factor." | 1.42 | Early-Onset Convulsive Seizures Induced by Brain Hypoxia-Ischemia in Aging Mice: Effects of Anticonvulsive Treatments. ( Aljarallah, S; Eubanks, JH; Gao, X; Huang, Y; McDonald, R; Patel, N; Peng, J; Wang, J; Wu, C; Zhang, L, 2015) |
| "In the maximal electroshock seizure screen, compounds 5c and 5d showed moderate levels of anticonvulsant activity and protected 100% of the animals at a dose of 100 mg/kg." | 1.40 | Design, synthesis and evaluation of the antidepressant and anticonvulsant activities of triazole-containing quinolinones. ( Deng, XQ; Quan, ZS; Song, MX; Zheng, Y, 2014) |
| "Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32mA, 6Hz, 3s stimulus duration) delivered via ocular electrodes; type II isobolographic analysis was used to characterize the consequent anticonvulsant interactions between the various drug combinations for fixed-ratios of 1:1, 1:2, 1:5 and 1:10." | 1.40 | Interactions of levetiracetam with carbamazepine, phenytoin, topiramate and vigabatrin in the mouse 6Hz psychomotor seizure model - a type II isobolographic analysis. ( Florek-Luszczki, M; Luszczki, JJ; Wlaz, A, 2014) |
| "Pregabalin reduced the percentage of seizures and increased the latency to seizure in the MES model in two parental mouse strains used to construct the mutants." | 1.40 | Anticonvulsant activity of pregabalin in the maximal electroshock-induced seizure assay in α2δ1 (R217A) and α2δ2 (R279A) mouse mutants. ( Donevan, S; Galvin, S; Hain, H; Lotarski, S; Offord, J; Peterson, J; Strenkowski, B, 2014) |
| "Carbamazepine was used as a positive control." | 1.39 | The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels. ( Andreatini, R; Biojone, C; Casarotto, PC; Correia, D; Guimarães, FS; Joca, SL; Martynhak, BJ; Pereira, M; Siba, IP; Tonelli, DA, 2013) |
| "The present study was aimed to characterize the anticonvulsant effects of piperine in combination with well established antiepileptic drug (AED) phenytoin, in the mouse maximal electroshock (MES)-induced seizure model by using the type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs)." | 1.39 | Combination therapy of piperine and phenytoin in maximal electroshock induced seizures in mice: isobolographic and biochemical analysis. ( Khanam, R; Pillai, KK; Saraogi, P; Vohora, D, 2013) |
| "Phenytoin (DPH) is an anticonvulsant drug that is widely used for the treatment of epilepsy." | 1.39 | A novel mouse model for phenytoin-induced liver injury: involvement of immune-related factors and P450-mediated metabolism. ( Fukami, T; Iida, A; Matsuo, K; Nakajima, M; Sasaki, E; Tsuneyama, K; Yokoi, T, 2013) |
| "In the animal seizure models tested, the anticonvulsant profile of indazole most resembled that of gabapentin and somewhat resembled those of the AMPA/kainate antagonist NBQX and the sodium channel inhibitor phenytoin, but differed from that of benzodiazepine." | 1.39 | Anticonvulsant action of indazole. ( Aoyama, K; Kikuchi-Utsumi, K; Matsumura, N; Nakaki, T; Sakamaki, K; Watabe, M, 2013) |
| "Phenytoin has two important properties that are advantageous for assessing the validity of the theta suppression model: 1) it is a standard antiepileptic drug with no known anxiolytic effects, and 2) its primary mechanism of action is through suppression of the persistent sodium current, an effect that should also suppress hippocampal theta." | 1.38 | A critical test of the hippocampal theta model of anxiolytic drug action. ( Dickson, CT; Treit, D; Yeung, M, 2012) |
| " Additionally, the effects of acute and chronic administration of both statins on the adverse effect potential of three antiepileptic drugs were assessed in the chimney test (motor performance) and passive avoidance task (long-term memory)." | 1.38 | The interactions of atorvastatin and fluvastatin with carbamazepine, phenytoin and valproate in the mouse maximal electroshock seizure model. ( Czuczwar, SJ; Luszczki, JJ; Stepien, KM; Tomaszewski, M, 2012) |
| " As such, we assessed the effect of daily chronic administration (75 mg/kg day 0 followed by 50 mg/kg daily i." | 1.37 | Dilantin therapy in an experimental model of traumatic brain injury: effects of limited versus daily treatment on neurological and behavioral recovery. ( Burnett, T; Chen, X; Chuang, J; Cummings, EE; Darrah, SD; Darrah, SH; Galang, GN; Mohler, LM; Reyes-Littaua, MC; Wagner, AK, 2011) |
| "That increased I(Nap) may contribute to seizure-like activity is indicated by the observation that feeding sda larvae the antiepileptic drug phenytoin, which was sufficient to reduce I(Nap), rescued both seizure-like episode duration and synaptic excitation of motoneurons." | 1.37 | Increased persistent Na+ current contributes to seizure in the slamdance bang-sensitive Drosophila mutant. ( Baines, RA; Marley, R, 2011) |
| "Curcumin was co-administered with sub-therapeutic dose of valproate 60min before PTZ injection." | 1.37 | Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. ( Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH, 2011) |
| "Infantile spasms are the signature seizures of West syndrome." | 1.37 | Carisbamate acutely suppresses spasms in a rat model of symptomatic infantile spasms. ( Galanopoulou, AS; Moshé, SL; Ono, T, 2011) |
| " Our findings strongly suggest that CoQ10 can be considered a safe and effective adjuvant to phenytoin therapy in epilepsy both to ameliorate seizure severity and to protect against seizure-induced oxidative damage by reducing the cognitive impairment and oxidative stress associated with chronic use of phenytoin." | 1.37 | Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress. ( Tawfik, MK, 2011) |
| "Epileptic seizures drive expression of the blood-brain barrier efflux transporter P-glycoprotein via a glutamate/cyclooxygenase-2 mediated signalling pathway." | 1.36 | COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats. ( Aronica, E; Edelbroek, PM; Gorter, JA; Holtman, L; Pekcec, A; Potschka, H; Schlichtiger, J; van Vliet, EA; Zibell, G, 2010) |
| "Diazepam and phenytoin were administered intraperitoneally at doses of 2 and 30 mg/kg, respectively, and brain and plasma concentrations were determined 60 min after administration using liquid chromatography-mass spectrometry." | 1.36 | Brain uptake of diazepam and phenytoin in a genetic animal model of absence epilepsy. ( Charman, SA; Davies, PJ; Nicolazzo, JA; Petrou, S; Steuten, JA; Taylor, N, 2010) |
| "Pretreatment with phenytoin (5 mg/kg) in combination with SMF had significantly greater effects on seizure latency and severity than either pretreatment alone." | 1.35 | Effects of a static magnetic field on audiogenic seizures in black Swiss mice. ( Engström, S; McLean, MJ; Polley, D; Polley, DB; Qinkun, Z; Spankovich, C, 2008) |
| "Treatment with phenobarbital or phenytoin caused a reduction in seizure frequency, but did not improve EEG background or prevent death." | 1.34 | The natural history and treatment of epilepsy in a murine model of tuberous sclerosis. ( Erbayat-Altay, E; Gutmann, DH; Wong, M; Xu, L; Zeng, LH, 2007) |
| "Chronic focal epilepsy was induced by injecting 25-50 ng of tetanus toxin or vehicle alone (controls) into the motor neocortex of rats." | 1.33 | Characterization of the tetanus toxin model of refractory focal neocortical epilepsy in the rat. ( Cock, HR; Nilsen, KE; Walker, MC, 2005) |
| "Although sound-induced (audiogenic) seizures in the genetically epilepsy-prone rat (GEPR) initially occur independent of the forebrain, repeated audiogenic seizures recruit forebrain seizure circuits in a process referred to as audiogenic kindling." | 1.33 | Brainstem seizure severity regulates forebrain seizure expression in the audiogenic kindling model. ( Browning, RA; Clough, RW; Jobe, PC; Merrill, MA, 2005) |
| "Phenytoin was effective in GAERS 2 mm more posteriorly." | 1.33 | Effect of systemic and intracortical administration of phenytoin in two genetic models of absence epilepsy. ( Aker, R; Berkman, K; Gurbanova, AA; Onat, FY; van Luijtelaar, G; van Rijn, CM, 2006) |
| "At subthreshold doses for seizure induction, picrotoxin produced an increased frequency of motor neuron action potential bursting, indicating that CNS GABAergic transmission regulates patterned activity." | 1.33 | Development of a Drosophila seizure model for in vivo high-throughput drug screening. ( Chouinard, SW; Littleton, JT; Saraswati, S; Stilwell, GE, 2006) |
| "ADD and seizure severity were also measured in response to both threshold and suprathreshold kindling stimulation." | 1.31 | Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of acute phenytoin. ( Bharadia, V; Gilbert, TH; Teskey, GC, 2001) |
| " The purpose of our study was to evaluate the effects of chronic administration of valproate (VPA), phenytoin (PHT), and MK-801 on the change in seizure phenotype observed in our model system." | 1.30 | Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis. ( Applegate, CD; Ozduman, K; Samoriski, GM, 1997) |
| " AWD 140-190 thus presents an orally active and safe anticonvulsant agent, which is structurally unrelated to anticonvulsants currently used." | 1.30 | AWD 140-190: a new anticonvulsant with a very good margin of safety. ( Bartsch, R; Engel, J; Rostock, A; Rundfeldt, C; Tober, C; Unverferth, K; White, HS; Wolf, HH, 1997) |
| " PHT pharmacokinetics was described by a pharmacokinetic model with Michaelis-Menten elimination." | 1.30 | Modelling of the pharmacodynamic interaction between phenytoin and sodium valproate. ( Danhof, M; Della Paschoa, OE; Voskuyl, RA, 1998) |
| "With fosphenytoin treatment 5 min after ischemia, hippocampal CA1 pyramidal neurons remained at near control level (13." | 1.30 | Fosphenytoin reduces hippocampal neuronal damage in rat following transient global ischemia. ( Chan, SA; Iyer, V; Miller, JJ; Reid, KH; Schurr, A; Tseng, MT, 1998) |
| "Treatment of phenytoin responders and nonresponders with other primary antiepileptic drugs showed that valproate and phenobarbital induced much smaller increases in focal seizure threshold in phenytoin nonresponders than in responders, whereas carbamazepine induced about the same threshold increase in both groups." | 1.29 | Pharmacological characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy. ( Hönack, D; Löscher, W; Rundfeldt, C, 1993) |
| " In contrast to the anticonvulsant effect, tolerance developed to the adverse effects, i." | 1.29 | Anticonvulsant efficacy and adverse effects of phenytoin during chronic treatment in amygdala-kindled rats. ( Löscher, W; Rundfeldt, C, 1993) |
| "Lifarizine was an effective neuroprotective agent in this model of focal ischaemia in the mouse." | 1.29 | Neuroprotective properties of lifarizine compared with those of other agents in a mouse model of focal cerebral ischaemia. ( Brown, CM; Calder, C; Kenny, BA; Linton, C; Patmore, L; Small, C; Spedding, M, 1995) |
| "Two protocols were used: assessment of seizures immediately after the completion of the kindling procedure and after the 2-week postkindling PTX-free period, as compared with acute PTX seizures." | 1.29 | Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models. ( Godlevsky, LS; Mazarati, AM; Shandra, AA; Vastyanov, RS, 1996) |
| "D-Cycloserine (DCS) is a high-efficacy partial agonist at the strychnine-insensitive glycine modulatory site within the N-methyl-D-aspartate (NMDA)-receptor/ionophore complex." | 1.29 | Influence of D-cycloserine on the anticonvulsant activity of phenytoin and carbamazepine against electroconvulsions in mice. ( Czuczwar, SJ; Roliński, Z; Wlaź, P, 1996) |
| "The seizures were predominantly clonic jerks accompanied by large spikes and slow waves lasting for 30-60s." | 1.29 | Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy. ( Satishchandra, P; Shankar, SK; Ullal, GR, 1996) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 1.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| "Carbamazepine and phenytoin were ineffective or aggravated the seizures." | 1.27 | Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat. ( Depaulis, A; Marescaux, C; Micheletti, G; Reis, J; Rumbach, L; Vergnes, M; Warter, JM, 1985) |
| "According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony." | 1.27 | Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985) |
| "An animal model of central distal axonopathy following chronic administration of phenytoin is described." | 1.27 | Damage of Purkinje cell axons following chronic phenytoin administration: an animal model of distal axonopathy. ( Kirchgässner, N; Volk, B, 1985) |
| "This situation may be similar to that in malignant hyperpyrexia (MH) occurring in mammals." | 1.26 | The chick as a model for malignant hyperpyrexia. ( Korczyn, AD; Shavit, S; Shlosberg, I, 1980) |
| "Gamma hydroxybutyrate (GHB) was administered intravenously to monkeys that had been pretreated orally for 2 weeks with various anticonvulsant drugs or with L-DOPA at different dosage levels." | 1.26 | Gamma hydroxybutyrate in the monkey. II. Effect of chronic oral anticonvulsant drugs. ( Snead, OC, 1978) |
| "Chlorpromazine that depresses decerebrate rigidity in a dose-related fashion requires 1." | 1.26 | Suppression of decerebrate rigidity by phenytoin and chlorpromazine. ( Anderson, RJ; Raines, A, 1976) |
| "3 Glycerol-induced acute renal failure produced a significant increase in the unbound fractions of o-methyl red, methyl orange, bromocresol green (BCG), 2-(4'-hydroxybenzeneazo) benzoic acid (HABA), phenytoin and salicylic acid." | 1.26 | Decreased binding of drugs and dyes to plasma proteins from rats with acute renal failure: effects of ureter ligation and intramuscular injection of glycerol. ( Bowmer, CJ; Lindup, WE, 1979) |
| "We conclude that phenytoin induced hyperkinesias reflect a specific effect of phenytoin on an abnormal neural substrate and suggest the presence of an otherwise silent pathological alteration of the corpus striatum." | 1.26 | Clinical and experimental studies of phenytoin-induced hyperkinesias. ( Klawans, HL; Koller, WC; Nausieda, PA; Weiner, WJ, 1979) |
| "Phenytoin and diazepam were maximally effective at concentrations of 20 microgram/ml and 3-4 microgram/ml, respectively, in good agreement with their effective concentrations in clinical practice." | 1.26 | The hippocampal slice: a system for studying the pharmacology of seizures and for screening anticonvulsant drugs. ( Hoffer, BJ; Oliver, AP; Wyatt, RJ, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 66 (22.60) | 18.7374 |
| 1990's | 40 (13.70) | 18.2507 |
| 2000's | 63 (21.58) | 29.6817 |
| 2010's | 107 (36.64) | 24.3611 |
| 2020's | 16 (5.48) | 2.80 |
| Authors | Studies |
|---|---|
| Hallot, A | 1 |
| Brodin, R | 1 |
| Merlier, J | 1 |
| Brochard, J | 1 |
| Chambon, JP | 1 |
| Biziere, K | 1 |
| Xie, ZF | 1 |
| Chai, KY | 1 |
| Piao, HR | 1 |
| Kwak, KC | 1 |
| Quan, ZS | 2 |
| Ragavendran, JV | 3 |
| Sriram, D | 3 |
| Patel, SK | 1 |
| Reddy, IV | 1 |
| Bharathwajan, N | 1 |
| Stables, J | 3 |
| Yogeeswari, P | 3 |
| Nageswari, Y | 1 |
| Kavya, R | 1 |
| Sreevatsan, N | 1 |
| Vanitha, K | 1 |
| Kotapati, S | 1 |
| Amin, KM | 1 |
| Rahman, DE | 1 |
| Al-Eryani, YA | 1 |
| Salomé, C | 2 |
| Salomé-Grosjean, E | 1 |
| Park, KD | 1 |
| Morieux, P | 1 |
| Swendiman, R | 1 |
| DeMarco, E | 1 |
| Stables, JP | 3 |
| Kohn, H | 2 |
| Zuliani, V | 1 |
| Fantini, M | 1 |
| Nigam, A | 1 |
| Patel, MK | 3 |
| Rivara, M | 1 |
| Baruah, PK | 1 |
| Dinsmore, J | 1 |
| King, AM | 1 |
| De Ryck, M | 1 |
| Kaminski, R | 1 |
| Provins, L | 1 |
| Walls, TH | 1 |
| Grindrod, SC | 1 |
| Beraud, D | 1 |
| Zhang, L | 3 |
| Baheti, AR | 1 |
| Dakshanamurthy, S | 1 |
| Brown, ML | 1 |
| MacArthur, LH | 1 |
| Rajak, H | 1 |
| Singh Thakur, B | 1 |
| Singh, A | 1 |
| Raghuvanshi, K | 1 |
| Sah, AK | 1 |
| Veerasamy, R | 1 |
| Sharma, PC | 1 |
| Singh Pawar, R | 1 |
| Kharya, MD | 1 |
| Harish, KP | 1 |
| Mohana, KN | 1 |
| Mallesha, L | 1 |
| Prasanna Kumar, BN | 1 |
| Malik, S | 1 |
| Bahare, RS | 1 |
| Khan, SA | 1 |
| Kamiński, K | 3 |
| Obniska, J | 4 |
| Chlebek, I | 1 |
| Wiklik, B | 1 |
| Rzepka, S | 1 |
| Ulloora, S | 1 |
| Shabaraya, R | 1 |
| Ranganathan, R | 1 |
| Adhikari, AV | 1 |
| Deng, XQ | 1 |
| Song, MX | 1 |
| Zheng, Y | 1 |
| Dawidowski, M | 1 |
| Chońska, J | 1 |
| Mika, W | 1 |
| Turło, J | 1 |
| Nikalje, APG | 1 |
| Shaikh, AN | 1 |
| Shaikh, SI | 1 |
| Kalam Khan, FA | 1 |
| Sangshetti, JN | 1 |
| Shinde, DB | 1 |
| Rapacz, A | 3 |
| Rybka, S | 2 |
| Powroźnik, B | 1 |
| Pękala, E | 1 |
| Filipek, B | 1 |
| Żmudzki, P | 2 |
| Tanaka, T | 1 |
| Yajima, N | 1 |
| Tanitame, A | 1 |
| Kiyoshi, T | 1 |
| Miura, Y | 1 |
| Edayadulla, N | 1 |
| Ramesh, P | 1 |
| Góra, M | 2 |
| Sałat, K | 2 |
| Czopek, A | 2 |
| Byrtus, H | 2 |
| Zagórska, A | 2 |
| Rychtyk, J | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Lamie, PF | 1 |
| El-Kalaawy, AM | 1 |
| Abdel Latif, NS | 1 |
| Rashed, LA | 1 |
| Philoppes, JN | 1 |
| Borowicz-Reutt, K | 2 |
| Banach, M | 6 |
| Alaraj, M | 3 |
| Saadh, MJ | 3 |
| Alafnan, A | 3 |
| Bernat, P | 1 |
| Kołodziejczyk, P | 1 |
| Łuszczki, JJ | 4 |
| Zagaja, M | 1 |
| Tutka, P | 2 |
| Bojar, H | 1 |
| Jankiewicz, K | 1 |
| Florek-Łuszczki, M | 2 |
| Chmielewski, J | 2 |
| Skalicka-Woźniak, K | 1 |
| Wang, L | 1 |
| Shi, H | 1 |
| Kang, Y | 1 |
| Guofeng, W | 1 |
| Dunn, EN | 1 |
| Matson, LM | 1 |
| Haines, KM | 1 |
| Whitten, KA | 1 |
| Lee-Stubbs, RB | 1 |
| Berger, KE | 1 |
| McCarren, HS | 1 |
| Ardinger, CE | 1 |
| Jackson Piercy, CE | 1 |
| Miller-Smith, SM | 1 |
| McDonough, JH | 2 |
| Mahmoud, DB | 1 |
| Afifi, SA | 1 |
| El Sayed, NS | 1 |
| Łukawski, K | 1 |
| Czuczwar, SJ | 9 |
| Kumar, R | 1 |
| Arora, R | 1 |
| Sarangi, SC | 1 |
| Ganeshan N, S | 1 |
| Agarwal, A | 1 |
| Kaleekal, T | 1 |
| Gupta, YK | 5 |
| Borowicz-Reutt, KK | 3 |
| Yoshioka, H | 1 |
| Ramakrishnan, SS | 1 |
| Suzuki, A | 1 |
| Iwata, J | 1 |
| Bertram, EH | 1 |
| Edelbroek, P | 1 |
| Cho, SJ | 1 |
| Park, E | 1 |
| Baker, A | 1 |
| Reid, AY | 1 |
| Niquet, J | 1 |
| Baldwin, R | 1 |
| Norman, K | 1 |
| Suchomelova, L | 1 |
| Lumley, L | 1 |
| Wasterlain, CG | 2 |
| Popławska, M | 1 |
| Gao, F | 1 |
| Gao, Y | 1 |
| Meng, F | 1 |
| Yang, C | 2 |
| Fu, J | 1 |
| Li, Y | 2 |
| von Mässenhausen, A | 1 |
| Tonnus, W | 1 |
| Himmerkus, N | 1 |
| Parmentier, S | 1 |
| Saleh, D | 1 |
| Rodriguez, D | 1 |
| Ousingsawat, J | 1 |
| Ang, RL | 1 |
| Weinberg, JM | 1 |
| Sanz, AB | 1 |
| Ortiz, A | 1 |
| Zierleyn, A | 1 |
| Becker, JU | 1 |
| Baratte, B | 1 |
| Desban, N | 1 |
| Bach, S | 1 |
| Schiessl, IM | 1 |
| Nogusa, S | 1 |
| Balachandran, S | 1 |
| Anders, HJ | 1 |
| Ting, AT | 1 |
| Bleich, M | 1 |
| Degterev, A | 1 |
| Kunzelmann, K | 1 |
| Bornstein, SR | 1 |
| Green, DR | 1 |
| Hugo, C | 1 |
| Linkermann, A | 1 |
| Tchekalarova, J | 1 |
| da Conceição Machado, K | 1 |
| Gomes Júnior, AL | 1 |
| de Carvalho Melo Cavalcante, AA | 1 |
| Momchilova, A | 1 |
| Tzoneva, R | 1 |
| Hemmati, AA | 1 |
| Larki-Harchegani, A | 1 |
| Shabib, S | 1 |
| Jalali, A | 1 |
| Rezaei, A | 1 |
| Housmand, G | 1 |
| Baker, EM | 1 |
| Thompson, CH | 1 |
| Hawkins, NA | 1 |
| Wagnon, JL | 1 |
| Wengert, ER | 1 |
| George, AL | 1 |
| Meisler, MH | 2 |
| Kearney, JA | 1 |
| Luszczki, JJ | 7 |
| Mazurkiewicz, LP | 1 |
| Wroblewska-Luczka, P | 1 |
| Wlaz, A | 2 |
| Ossowska, G | 1 |
| Szpringer, M | 1 |
| Zolkowska, D | 2 |
| Florek-Luszczki, M | 2 |
| Mirnezami, M | 1 |
| Rahimi, H | 1 |
| Fakhar, HE | 1 |
| Rezaei, K | 1 |
| Hamoy, M | 1 |
| Dos Santos Batista, L | 1 |
| de Mello, VJ | 1 |
| Gomes-Leal, W | 1 |
| Farias, RAF | 1 |
| Dos Santos Batista, P | 1 |
| do Nascimento, JLM | 1 |
| Marcondes, HC | 1 |
| Taylor, JG | 1 |
| Hutchison, WD | 1 |
| Torres, MF | 1 |
| Barbas, LAL | 1 |
| Sawicka, KM | 1 |
| Wawryniuk, A | 1 |
| Daniluk, J | 1 |
| Karwan, S | 2 |
| Marzeda, P | 1 |
| Gut-Lepiech, A | 1 |
| Kondrat-Wróbel, MW | 1 |
| Wróblewska-Łuczka, P | 1 |
| Plech, T | 1 |
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| Shafaat, O | 1 |
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| Bednarski, J | 1 |
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| Ognik, J | 1 |
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| Sun, Z | 1 |
| Zhong, XL | 1 |
| Zong, Y | 1 |
| Wu, ZC | 1 |
| Zhang, Q | 2 |
| Yu, JT | 1 |
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| Waxman, SG | 8 |
| Lotarski, S | 1 |
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| Wasowski, C | 1 |
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| Mangialavori, IC | 1 |
| Bruno-Blanch, LE | 1 |
| Marder, M | 1 |
| Borowicz, KK | 6 |
| Zarczuk, R | 2 |
| Latalski, M | 1 |
| Borowicz, KM | 1 |
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| Löscher, W | 11 |
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| Rosillo-de la Torre, A | 1 |
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| Orozco-Suárez, S | 2 |
| Garcia Casillas, PE | 1 |
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| Ying, X | 1 |
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| Taborda, F | 1 |
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| Bruno Blanch, L | 1 |
| Ai, XY | 1 |
| Liu, HJ | 1 |
| Lu, C | 1 |
| Liang, CL | 1 |
| Sun, Y | 1 |
| Sun, B | 1 |
| Liu, YR | 1 |
| Liu, XQ | 1 |
| Xiao, T | 1 |
| Jing, XS | 1 |
| Sun, T | 1 |
| Zhou, HG | 1 |
| McLean, MJ | 1 |
| Engström, S | 1 |
| Qinkun, Z | 1 |
| Spankovich, C | 1 |
| Polley, DB | 1 |
| Polley, D | 1 |
| Bankstahl, JP | 1 |
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| Yaro, AH | 1 |
| Abubakar, MS | 1 |
| Anuka, JA | 1 |
| Hussaini, IM | 1 |
| Bernášková, K | 1 |
| Mareš, P | 4 |
| Bourin, M | 1 |
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| Hascoët, M | 1 |
| van Vliet, EA | 3 |
| Zibell, G | 1 |
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| Edelbroek, PM | 3 |
| Holtman, L | 1 |
| Aronica, E | 2 |
| Gorter, JA | 3 |
| Potschka, H | 2 |
| Cuellar-Herrera, M | 1 |
| Peña, F | 1 |
| Alcantara-Gonzalez, D | 1 |
| Neri-Bazan, L | 1 |
| Wang, X | 2 |
| Chen, J | 1 |
| Wang, M | 1 |
| Gu, Y | 1 |
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| Wadman, WJ | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Cohort Study of Association Between Steady State Phenytoin Treatment and Better Clinical Parameters of Glaucoma[NCT00739154] | 200 participants (Anticipated) | Observational | 2008-11-30 | Not yet recruiting | |||
| Effect of the Treatment of Vitamin D Deficiency in Drug-resistant Epilepsy[NCT03475225] | Phase 3 | 400 participants (Anticipated) | Interventional | 2018-04-30 | Not yet recruiting | ||
| OxCarbazepine as a Neuroprotective Agent in MS: A Phase 2a Trial[NCT02104661] | Phase 2 | 30 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 reviews available for phenytoin and Disease Models, Animal
| Article | Year |
|---|---|
Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Disease Models, Animal; Electroencephal | 2016 |
Genes, environment, and orofacial clefting: N-acetyltransferase and folic acid.
Topics: 6-Aminonicotinamide; Animals; Arylamine N-Acetyltransferase; Cleft Lip; Cleft Palate; Disease Models | 2010 |
[Treatment of status epilepticus].
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electric Stimulation Therapy; Humans; Ma | 2001 |
How urgent is the treatment of nonconvulsive status epilepticus?
Topics: Adult; Animals; Anticonvulsants; Benzodiazepines; Child; Cognition Disorders; Disease Models, Animal | 2007 |
Phenytoin protects central axons in experimental autoimmune encephalomyelitis.
Topics: Animals; Axons; Central Nervous System; Disease Models, Animal; Encephalomyelitis, Autoimmune, Exper | 2008 |
Quantitative variation in hormonal receptors and clefting in the mouse.
Topics: Animals; Cleft Palate; Cortisone; Dexamethasone; Disease Models, Animal; Disease Susceptibility; HLA | 1980 |
Biochemical and molecular teratology of fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Disease Models, Animal; Epilepsy; Face; Female; Fet | 1994 |
Pathogenesis of drug-induced gingival overgrowth. A review of studies in the rat model.
Topics: Age Factors; Animals; Anticonvulsants; Calcium Channel Blockers; Cyclosporine; Dental Plaque; Diseas | 1996 |
Oxcarbazepine.
Topics: Adult; Animals; Anticonvulsants; Biological Availability; Biotransformation; Carbamazepine; Controll | 1999 |
Conceptual issues in the use of drugs for the treatment of aggression in man.
Topics: Adolescent; Adult; Aggression; Alcoholic Intoxication; Animals; Anti-Anxiety Agents; Anticonvulsants | 1975 |
Drugs and chemicals associated with intrauterine growth deficiency.
Topics: Abnormalities, Drug-Induced; Adult; Aminopterin; Animals; Disease Models, Animal; Ethanol; Female; F | 1978 |
Pharmacological and biochemical studies in epileptic fowl.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Chickens; Disease Models, Animal; Ethosuximide; | 1979 |
Pharmacological prophylaxis in the kindling model of epilepsy.
Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carba | 1977 |
Effects of different classes of antiepileptic drugs on brain-stem pathways.
Topics: Animals; Anticonvulsants; Baclofen; Brain Stem; Carbamazepine; Disease Models, Animal; Electroshock; | 1985 |
Febrile convulsions. A reappraisal.
Topics: Age Factors; Animals; Animals, Newborn; Body Temperature; Brain; Brain Damage, Chronic; Child, Presc | 1973 |
Epileptic therapy and gingival considerations.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Disease Models, Animal; Epilepsy; Female; Gingi | 1974 |
2 trials available for phenytoin and Disease Models, Animal
| Article | Year |
|---|---|
Canine status epilepticus: a translational platform for human therapeutic trials.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Double-Bli | 2011 |
Interaction profile of Zizyphus jujuba with phenytoin, phenobarbitone, and carbamazepine in maximal electroshock-induced seizures in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Chi-Square Distribution; Chromat | 2012 |
274 other studies available for phenytoin and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Ele | 1986 |
Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Mice; Neurotoxicity Syndromes; Quinolines; Seizure | 2005 |
Design and synthesis of anticonvulsants from a combined phthalimide-GABA-anilide and hydrazone pharmacophore.
Topics: Anilides; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hydrazones; Mal | 2007 |
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; | 2007 |
Newer GABA derivatives for the treatment of epilepsy including febrile seizures: a bioisosteric approach.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Dru | 2008 |
Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Male; | 2008 |
Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides.
Topics: Acetamides; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Hippocampus | 2010 |
Anticonvulsant activity of 2,4(1H)-diarylimidazoles in mice and rats acute seizure models.
Topics: Administration, Oral; Animals; Anticonvulsants; Cell Line; Disease Models, Animal; Humans; Imidazole | 2010 |
Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides.
Topics: Acetamides; Amino Acids; Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclini | 2012 |
Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent.
Topics: Animals; Disease Models, Animal; Drug Design; Female; Fluorescence; Fluorescent Dyes; Models, Molecu | 2012 |
Novel limonene and citral based 2,5-disubstituted-1,3,4-oxadiazoles: a natural product coupled approach to semicarbazones for antiepileptic activity.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Binding Sites; Cyclohexenes; Disease Models, Animal; | 2013 |
Synthesis of novel 1-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-piperazine derivatives and evaluation of their in vivo anticonvulsant activity.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Male; Mice; Molecular Structure; Mot | 2013 |
Design, synthesis and anticonvulsant evaluation of N-(benzo[d]thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)-carbothioamide derivatives: a hybrid pharmacophore approach.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Disease Models, | 2013 |
Design, synthesis and anticonvulsant properties of new N-Mannich bases derived from 3-phenylpyrrolidine-2,5-diones.
Topics: Administration, Oral; Animals; Anticonvulsants; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhib | 2013 |
Synthesis, anticonvulsant and anti-inflammatory studies of new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Carrageenan; Disease Models, Anim | 2013 |
Design, synthesis and evaluation of the antidepressant and anticonvulsant activities of triazole-containing quinolinones.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Disease Models, Animal; Dose-Resp | 2014 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ep | 2014 |
Microwave assisted synthesis and docking study of N-(2-oxo-2-(4-oxo-2-substituted thiazolidin-3ylamino)ethyl)benzamide derivatives as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Benzamides; Binding Sites; Disease Models, Animal; Half-Life; Liver; Mice; | 2014 |
Design, synthesis and biological activity of new amides derived from 3-methyl-3-phenyl-2,5-dioxo-pyrrolidin-1-yl-acetic acid.
Topics: Acetates; Amides; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug | 2015 |
Discovery of benzothiazine derivatives as novel, orally-active anti-epileptic drug candidates with broad anticonvulsant effect.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, | 2015 |
Synthesis of 2,6-dicarbethoxy-3,5-diaryltetrahydro-1,4-thiazine-1,1-dioxide derivatives as potent anticonvulsant agents.
Topics: Animals; Anticonvulsants; Crystallography, X-Ray; Cyclic S-Oxides; Disease Models, Animal; Dose-Resp | 2015 |
Synthesis, and anticonvulsant activity of new amides derived from 3-methyl- or 3-ethyl-3-methyl-2,5-dioxo-pyrrolidin-1-yl-acetic acids.
Topics: Amides; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electros | 2016 |
Synthesis and pharmacological evaluation of novel N-Mannich bases derived from 5,5-diphenyl and 5,5-di(propan-2-yl)imidazolidine-2,4-dione core.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Imidazolidines; | 2019 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Pyrazolo[3,4-d]pyrimidine-based dual EGFR T790M/HER2 inhibitors: Design, synthesis, structure-activity relationship and biological activity as potential antitumor and anticonvulsant agents.
Topics: Animals; Anticonvulsants; Antineoplastic Agents; Apoptosis; Cell Line; Cell Proliferation; Cell Surv | 2021 |
Trimetazidine, an Anti-Ischemic Drug, Reduces the Antielectroshock Effects of Certain First-Generation Antiepileptic Drugs.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res | 2022 |
Insulin potentiates the anticonvulsive activity of phenytoin against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Diabetes Mellitus, Experimental; Disease Models, Animal; Electroshock; Ins | 2022 |
Insulin potentiates the anticonvulsive activity of phenytoin against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Diabetes Mellitus, Experimental; Disease Models, Animal; Electroshock; Ins | 2022 |
Insulin potentiates the anticonvulsive activity of phenytoin against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Diabetes Mellitus, Experimental; Disease Models, Animal; Electroshock; Ins | 2022 |
Insulin potentiates the anticonvulsive activity of phenytoin against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Diabetes Mellitus, Experimental; Disease Models, Animal; Electroshock; Ins | 2022 |
Ranolazine Interacts Antagonistically with Some Classical Antiepileptic Drugs-An Isobolographic Analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res | 2022 |
Interaction of Varenicline with Classic Antiseizure Medications in the Mouse Maximal Electroshock-Induced Seizure Model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2023 |
Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic-clonic seizure model: an isobolographic transformation.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2023 |
Hippocampal low-frequency stimulation improves cognitive function in pharmacoresistant epileptic rats.
Topics: Animals; Anticonvulsants; Cognition; Disease Models, Animal; Electric Stimulation; Epilepsy; Hippoca | 2020 |
Evaluation of fosphenytoin, levetiracetam, and propofol as treatments for nerve agent-induced seizures in pediatric and adult rats.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Disease Models, Animal; Female; Levetiracetam; Male; O | 2020 |
Crown Ether Nanovesicles (Crownsomes) Repositioned Phenytoin for Healing of Corneal Ulcers.
Topics: Administration, Ophthalmic; Animals; Cornea; Corneal Ulcer; Crown Ethers; Disease Models, Animal; Dr | 2020 |
Developing precision treatments for epilepsy using patient and animal models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Humans; Lamotrigine; Phenytoin | 2021 |
Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats.
Topics: Adjuvants, Pharmaceutic; Animals; Anticonvulsants; Behavior, Animal; Centella; Cognitive Dysfunction | 2021 |
Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2021 |
Phenytoin Inhibits Cell Proliferation through microRNA-196a-5p in Mouse Lip Mesenchymal Cells.
Topics: Animals; Cell Line; Cell Proliferation; Cleft Lip; Disease Models, Animal; Embryo, Mammalian; Female | 2021 |
Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsy; Levetiracetam; Pharmaceut | 2021 |
Post-Traumatic Epilepsy in Zebrafish Is Drug-Resistant and Impairs Cognitive Function.
Topics: Animals; Anticonvulsants; Carbamazepine; Cognitive Dysfunction; Disease Models, Animal; Drug Resista | 2021 |
Simultaneous triple therapy for the treatment of status epilepticus.
Topics: Animals; Anticonvulsants; Brain Waves; Combined Modality Therapy; Disease Models, Animal; Dose-Respo | 2017 |
Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Avoidance Learning; Brain; Disease Models, Animal; | 2017 |
The Sphingosine 1-Phosphate Analogue FTY720 Alleviates Seizure-induced Overexpression of P-Glycoprotein in Rat Hippocampus.
Topics: Anilides; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cycloox | 2018 |
Phenytoin inhibits necroptosis.
Topics: Acute Kidney Injury; Animals; Anticonvulsants; Biopsy; Disease Models, Animal; Gene Knockout Techniq | 2018 |
Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.
Topics: Animals; Anticonvulsants; Cannabinoid Receptor Agonists; Diazepam; Disease Models, Animal; Dose-Resp | 2018 |
Wound healing property of milk in full thickness wound model of rabbit.
Topics: Animals; Cattle; Disease Models, Animal; Hydroxyproline; Male; Milk; Ointments; Phenytoin; Powders; | 2018 |
The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy.
Topics: Action Potentials; Animals; Anticonvulsants; Brain Diseases; Disease Models, Animal; Drug Administra | 2018 |
Combination of phenobarbital with phenytoin and pregabalin produces synergy in the mouse tonic-clonic seizure model: An isobolographic analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Disease Models, Animal; Drug Synergism; Drug Th | 2018 |
The Role of Topical Estrogen, Phenytoin, and Silver Sulfadiazine in Time to Wound Healing in Rats.
Topics: Administration, Topical; Animals; Disease Models, Animal; Estrogens; Iran; Phenytoin; Punctures; Rat | 2018 |
Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Electroencephalography; Pen | 2018 |
Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Mo | 2019 |
New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Synergism; | 2019 |
The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling, | 2019 |
The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Carbamazepine; Disease Models, Animal; Dose-Response Re | 2013 |
Combination therapy of piperine and phenytoin in maximal electroshock induced seizures in mice: isobolographic and biochemical analysis.
Topics: Alkaloids; Animals; Anticonvulsants; Benzodioxoles; Calcium; Disease Models, Animal; Drug Therapy, C | 2013 |
Cytisine inhibits the anticonvulsant activity of phenytoin and lamotrigine in mice.
Topics: Alkaloids; Animals; Anticonvulsants; Azocines; Disease Models, Animal; Dose-Response Relationship, D | 2013 |
Activation of adenosine receptor potentiates the anticonvulsant effect of phenytoin against amygdala kindled seizures.
Topics: Adenosine-5'-(N-ethylcarboxamide); Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Elect | 2015 |
A novel mouse model for phenytoin-induced liver injury: involvement of immune-related factors and P450-mediated metabolism.
Topics: Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inh | 2013 |
Interactions of levetiracetam with carbamazepine, phenytoin, topiramate and vigabatrin in the mouse 6Hz psychomotor seizure model - a type II isobolographic analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Disease Models, Animal; Drug Combinatio | 2014 |
P-glycoprotein alters blood-brain barrier penetration of antiepileptic drugs in rats with medically intractable epilepsy.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri | 2013 |
Efficacy of dexamethasone on penicillin-induced epileptiform activity in rats: an electrophysiological study.
Topics: Animals; Anticonvulsants; Brain; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, | 2014 |
Tapered withdrawal of phenytoin removes protective effect in EAE without inflammatory rebound and mortality.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Encephalomyelitis, Autoimmune, Experi | 2014 |
Anticonvulsant activity of pregabalin in the maximal electroshock-induced seizure assay in α2δ1 (R217A) and α2δ2 (R279A) mouse mutants.
Topics: Animals; Anticonvulsants; Calcium Channels; Disease Models, Animal; Dose-Response Relationship, Drug | 2014 |
A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain Injuries; Disease Models, Animal; Flunitrazep | 2014 |
Reboxetine and its influence on the action of classical antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Drug Interactions; Electrosh | 2014 |
Effects of topical phenytoin on nasal wound healing after mechanical trauma: An experimental study.
Topics: Administration, Topical; Animals; Anticonvulsants; Disease Models, Animal; Male; Nasal Mucosa; Nose; | 2014 |
Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri | 2014 |
Abbreviated levetiracetam treatment effects on behavioural and histological outcomes after experimental TBI.
Topics: Animals; Brain Injuries; Contusions; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2015 |
Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Brain; Carbamazepine; Cells, Cultured; Central Nervous | 2014 |
Low dose zinc supplementation beneficially affects seizure development in experimental seizure models in rats.
Topics: Animals; Anticonvulsants; Dietary Supplements; Disease Models, Animal; Male; Phenytoin; Rats; Rats, | 2015 |
Role of cytochrome P450-mediated metabolism and identification of novel thiol-conjugated metabolites in mice with phenytoin-induced liver injury.
Topics: Acetylcysteine; Activation, Metabolic; Alanine Transaminase; Animals; Anticonvulsants; Bile; Chemica | 2015 |
Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Resistance; Electrod | 2015 |
Genetic background of mice strongly influences treatment resistance in the 6 Hz seizure model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Levetiracetam; Male; Mice; Phenytoin | 2015 |
Pentylenetetrazol-induced seizure-like behavior and neural hyperactivity in the medicinal leech.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Convulsants; Disease Models, Anim | 2015 |
The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis.
Topics: Animals; Anticonvulsants; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell | 2015 |
Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs.
Topics: Adrenergic beta-Antagonists; Animals; Anticonvulsants; Arrhythmias, Cardiac; Disease Models, Animal; | 2015 |
New benzo[d]thiazol-2-yl-aminoacetamides as potential anticonvulsants: synthesis, activity and prediction of molecular properties.
Topics: Acetamides; Animals; Anticonvulsants; Benzothiazoles; Carbamazepine; Computer Simulation; Disease Mo | 2015 |
The AMPA receptor antagonist NBQX exerts anti-seizure but not antiepileptogenic effects in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Disease Models, Animal; Electroencephalography; Epilepsy, | 2015 |
Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish.
Topics: Allylglycine; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Fructose; Levetiracetam; M | 2015 |
Modeling early-onset post-ischemic seizures in aging mice.
Topics: Aging; Analysis of Variance; Animals; Anticonvulsants; Brain; Chi-Square Distribution; Disease Model | 2015 |
Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, | 2015 |
Urate synthesis and oxidative stress in phenytoin hepatotoxicity: the role of antioxidant vitamins.
Topics: Animals; Antioxidants; Ascorbic Acid; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotec | 2014 |
Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Levetiracetam; Male; Mice | 2015 |
Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: A repertoire of Glycyrrhiza glabra flavonoid antioxidants.
Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Brain; Cognition; Cognition Diso | 2016 |
Validation of the 6 Hz refractory seizure mouse model for intracerebroventricularly administered compounds.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Capillary Permeability; Catheters, Indwelling; Cornea | 2015 |
Reversal of P-glycoprotein overexpression by Ginkgo biloba extract in the brains of pentylenetetrazole-kindled and phenytoin-treated mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caspase 3; Disease Models, | 2015 |
Injectable phenytoin loaded polymeric microspheres for the control of temporal lobe epilepsy in rats.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Delayed-Action Preparations; Disease Models, Animal; Drug | 2015 |
Synaptic vesicle protein2A decreases in amygdaloid-kindling pharmcoresistant epileptic rats.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Drug Resistance; Electric Stimulation; E | 2015 |
Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzothiazoles; Disease Models, Animal; Dose-Response | 2016 |
Cardioprotective Effect of Phenytoin on Doxorubicin-induced Cardiac Toxicity in a Rat Model.
Topics: Animals; Breast Neoplasms; Cardiomyopathies; Cardiotoxicity; Cytoprotection; Disease Models, Animal; | 2016 |
Amitriptyline and phenytoin prevents memory deficit in sciatic nerve ligation model of neuropathic pain.
Topics: Amitriptyline; Animals; Disease Models, Animal; Ligation; Male; Memory Disorders; Neuralgia; Pain Me | 2016 |
Early-Onset Convulsive Seizures Induced by Brain Hypoxia-Ischemia in Aging Mice: Effects of Anticonvulsive Treatments.
Topics: Age of Onset; Aging; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Hippocampus; | 2015 |
Phenytoin carried by silica core iron oxide nanoparticles reduces the expression of pharmacoresistant seizures in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Carriers; Drug Resistance; Ferric Compounds; | 2015 |
Modulation of brain glutamate dehydrogenase as a tool for controlling seizures.
Topics: Animals; Anticonvulsants; Brain; Deamination; Diazepam; Disease Models, Animal; Enzyme Inhibitors; G | 2015 |
Biological roles of KGF, CTGF and TGF-β in cyclosporine-A- and phenytoin- induced gingival overgrowth: A comparative experimental animal study.
Topics: Animals; Connective Tissue Growth Factor; Cyclosporine; Disease Models, Animal; Epithelium; Fibrobla | 2016 |
Propafenone enhances the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res | 2016 |
Electroresponsive Nanoparticles Improve Antiseizure Effect of Phenytoin in Generalized Tonic-Clonic Seizures.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Delivery Systems; Epilepsy, Tonic-Clon | 2016 |
Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chronic Disease; Disease Models, A | 2016 |
Design, synthesis, anticonvulsant, and antiarrhythmic properties of novel N-Mannich base and amide derivatives of β-tetralinohydantoin.
Topics: Amides; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Disease Models, Animal; Drug Design; Elect | 2016 |
Phenytoin accelerates tendon healing in a rat model of Achilles tendon rupture.
Topics: Achilles Tendon; Animals; Disease Models, Animal; Injections, Intraperitoneal; Male; Phenytoin; Rats | 2016 |
New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, M | 2017 |
Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action.
Topics: Animals; Anti-Infective Agents, Local; Cytokine Receptor gp130; Disease Models, Animal; Immunologic | 2017 |
Effects of a static magnetic field on audiogenic seizures in black Swiss mice.
Topics: Acoustic Stimulation; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Disease Models, | 2008 |
Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus.
Topics: Amygdala; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Diazepam; Disease | 2008 |
Anticonvulsant activity of Carissa edulis (Vahl) (Apocynaceae) root bark extract.
Topics: Administration, Oral; Animals; Anticonvulsants; Apocynaceae; Chickens; Disease Models, Animal; Dose- | 2008 |
Similar effects of lamotrigine and phenytoin against cortical epileptic foci in immature rats.
Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Disease Models, Animal; Dose-Response Relations | 2010 |
Anticonvulsant effect of Ficus religiosa: role of serotonergic pathways.
Topics: Animals; Anticonvulsants; Cyproheptadine; Diazepam; Disease Models, Animal; Dose-Response Relationsh | 2009 |
Topiramate and phenytoin anti-immobility effect in the mice forced swimming test is reversed by veratrine: Implication for bipolar depression treatment.
Topics: Animals; Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Disease Models, Animal; Dose- | 2009 |
COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri | 2010 |
Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Electric Stim | 2010 |
[Influence of scorpion alcoholic extraction on mdr1 mRNA and P-gp expression in brain of phenytoin-resistant convulsive rats].
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Disease Models, Animal; Eth | 2009 |
Brain uptake of diazepam and phenytoin in a genetic animal model of absence epilepsy.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Cerebrovascular Circulation; Chromatography, L | 2010 |
Effect of prolonged phenytoin administration on rat brain gene expression assessed by DNA microarrays.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Body Weight; Brain; Disease Models, Animal; Frontal Lob | 2010 |
Influence of etoricoxib on anticonvulsant activity of phenytoin and diazepam in experimental seizure models in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I | 2010 |
Effects of three N-(carboxyanilinomethyl) derivatives of p-isopropoxyphenylsuccinimide on the anticonvulsant action of carbamazepine, phenobarbital, phenytoin and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Aniline Compounds; Animals; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Models, | 2010 |
Dilantin therapy in an experimental model of traumatic brain injury: effects of limited versus daily treatment on neurological and behavioral recovery.
Topics: Animals; Blotting, Western; Brain; Brain Injuries; Disease Models, Animal; GAP-43 Protein; Male; Maz | 2011 |
Phenytoin at optimum doses ameliorates experimental autoimmune encephalomyelitis via modulation of immunoregulatory cells.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Immun | 2011 |
Increased persistent Na+ current contributes to seizure in the slamdance bang-sensitive Drosophila mutant.
Topics: Action Potentials; Animals; Anticonvulsants; Calcium Channels; Cnidarian Venoms; Disease Models, Ani | 2011 |
Early postnatal exposure of rats to lamotrigine, but not phenytoin, reduces seizure threshold in adulthood.
Topics: Aging; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Female; Lamotrigine; Male; Phenyt | 2011 |
Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Curcumin; Disease Models, Animal; Drug Interactions; Drug T | 2011 |
Effects of high frequency electrical stimulation and R-verapamil on seizure susceptibility and glutamate and GABA release in a model of phenytoin-resistant seizures.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Drug Resistance; Electric Stimulation; Extr | 2011 |
A critical test of the hippocampal theta model of anxiolytic drug action.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Biophysics; Diazepam; Disease Models, A | 2012 |
Carisbamate acutely suppresses spasms in a rat model of symptomatic infantile spasms.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Carbamates; Disease Models, Animal; Do | 2011 |
Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress.
Topics: Analysis of Variance; Animals; Anticonvulsants; Avoidance Learning; Catalase; Cognition Disorders; D | 2011 |
The interactions of atorvastatin and fluvastatin with carbamazepine, phenytoin and valproate in the mouse maximal electroshock seizure model.
Topics: Animals; Anticonvulsants; Atorvastatin; Brain; Carbamazepine; Disease Models, Animal; Drug Interacti | 2012 |
Effects of phenytoin sodium on dura mater healing in a rat model of CSF leakage.
Topics: Animals; Anticonvulsants; Cerebrospinal Fluid Leak; Cerebrospinal Fluid Rhinorrhea; Disease Models, | 2011 |
A rat model for LGI1-related epilepsies.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Brain; Carbamazepine; Cells, Cultured; Chlorocebus ae | 2012 |
Effects of pretreatment with etomidate, ketamine, phenytoin, and phenytoin/midazolam on acute, lethal cocaine toxicity.
Topics: Animals; Cocaine; Disease Models, Animal; Etomidate; Ketamine; Mice; Midazolam; Phenytoin; Random Al | 2012 |
Overexpression of multidrug resistance-associated protein 2 in the brain of pentylenetetrazole-kindled rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Chromatography, Liquid; Coloring Agents; Conv | 2012 |
Anticonvulsant action of indazole.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2013 |
Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish.
Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase; Amines; Animals; Anticonvulsants; Brain; Cycloh | 2013 |
Effects of classical antiepileptics on thresholds for phenomena induced by cortical stimulation in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electric Stimulation; Electroencephalography; Elec | 2002 |
Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Chi-Square Distribution; Diazepam; Disease Models, Animal | 2002 |
Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis.
Topics: Animals; Axons; Cell Death; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Imm | 2002 |
Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivo.
Topics: Animals; Axonal Transport; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Male | 2003 |
Valproate suppresses status epilepticus induced by 4-aminopyridine in CA1 hippocampus region.
Topics: 4-Aminopyridine; Animals; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; E | 2003 |
Motor disturbances in mice with deficiency of the sodium channel gene Scn8a show features of human dystonia.
Topics: Animals; Anti-Dyskinesia Agents; Anticonvulsants; Biperiden; Brain; Diazepam; Disease Models, Animal | 2003 |
Effects of fosphenytoin on nerve agent-induced status epilepticus.
Topics: Animals; Anticonvulsants; Atropine; Chemical Warfare Agents; Diazepam; Disease Models, Animal; Dose- | 2004 |
Modulation of antiepileptic effect of phenytoin and carbamazepine by melatonin in mice.
Topics: Animals; Anticonvulsants; Area Under Curve; Carbamazepine; Chromatography, High Pressure Liquid; Dis | 2004 |
Phenytoin treatment reduces atherosclerosis in mice through mechanisms independent of plasma HDL-cholesterol concentration.
Topics: Analysis of Variance; Animals; Apolipoproteins E; Arteriosclerosis; Cholesterol, HDL; Diet, Atheroge | 2004 |
The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats.
Topics: Animals; Anticonvulsants; Cilastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Elec | 2004 |
Pharmacoresistance and expression of multidrug transporter P-glycoprotein in kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cerebra | 2004 |
Sodium channel blockade with phenytoin protects spinal cord axons, enhances axonal conduction, and improves functional motor recovery after contusion SCI.
Topics: Animals; Anticonvulsants; Axons; Behavior, Animal; Disease Models, Animal; Electrophysiology; Male; | 2004 |
Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models.
Topics: Action Potentials; Animals; Anticonvulsants; Brain; Cobalt; Disease Models, Animal; Drug Combination | 2004 |
Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.
Topics: Animals; Axons; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gliosis | 2005 |
Interactions between riluzole and conventional antiepileptic drugs -- a comparison of results obtained in the subthreshold method and isobolographic analysis.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Electroshock; Ma | 2004 |
Characterization of the tetanus toxin model of refractory focal neocortical epilepsy in the rat.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Diazepam; Disease Models, Animal; Electroencephal | 2005 |
Blockade of sodium channels by phenytoin protects ultrastructure and attenuates lipid peroxidation in experimental spinal cord injury.
Topics: Animals; Disease Models, Animal; Lipid Peroxidation; Male; Malondialdehyde; Methylprednisolone; Neur | 2005 |
Protection with estradiol in developmental models of apoptotic neurodegeneration.
Topics: Animals; Animals, Newborn; Apoptosis; Bicuculline; Blotting, Western; Brain; Caenorhabditis elegans | 2005 |
Norfluoxetine and fluoxetine have similar anticonvulsant and Ca2+ channel blocking potencies.
Topics: Animals; Anticonvulsants; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signa | 2005 |
Brainstem seizure severity regulates forebrain seizure expression in the audiogenic kindling model.
Topics: 5,7-Dihydroxytryptamine; Acoustic Stimulation; Animals; Brain; Brain Chemistry; Brain Stem; Disease | 2005 |
Neuroprotection by sodium channel blockade with phenytoin in an experimental model of glaucoma.
Topics: Administration, Oral; Animals; Axons; Cell Count; Cell Survival; Disease Models, Animal; Glaucoma; I | 2005 |
Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri | 2006 |
[An animal model of antiepileptic-induced osteoporosis in rats].
Topics: Animals; Anticonvulsants; Bone Density; Disease Models, Animal; Isoxazoles; Osteoporosis; Phenytoin; | 2006 |
Effect of systemic and intracortical administration of phenytoin in two genetic models of absence epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Drug Administration Routes; Ele | 2006 |
In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant.
Topics: Animals; Anticonvulsants; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, Drug; | 2006 |
Development of a Drosophila seizure model for in vivo high-throughput drug screening.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Behavior, Animal; Cell Survival; Convulsants; Disease | 2006 |
Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, M | 2007 |
Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of repeated administration.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; | 2007 |
Resistance to phenobarbital extends to phenytoin in a rat model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug R | 2007 |
Diminished response of CA1 neurons to antiepileptic drugs in chronic epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamazepine; Chronic Disease; Dentate Gyrus; Disease | 2007 |
The natural history and treatment of epilepsy in a murine model of tuberous sclerosis.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalograp | 2007 |
Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Lipid Peroxidation; Locomotion; Male; Mexiletine; | 2007 |
Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Acetamides; Algorithms; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease | 2007 |
Cholecalciferol enhances the anticonvulsant effect of conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Cholecalciferol; Disease Models, Animal | 2007 |
Acute and chronic treatment with mianserin differentially affects the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model.
Topics: Analysis of Variance; Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Brain; Car | 2007 |
Exacerbation of experimental autoimmune encephalomyelitis after withdrawal of phenytoin and carbamazepine.
Topics: Animals; Anticonvulsants; Antigens, CD; Axons; Carbamazepine; Cell Count; Disease Models, Animal; En | 2007 |
Preliminary explorations of the role of mitochondrial proteins in refractory epilepsy: some findings from comparative proteomics.
Topics: Animals; Anticonvulsants; Databases, Factual; Disease Models, Animal; Electric Stimulation; Electrop | 2007 |
Topical diphenylhydantoin sodium can improve healing in a diabetic incisional animal wound model.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Evaluation, Preclin | 2007 |
Development of tolerance to levetiracetam in rats with chronic epilepsy.
Topics: Animals; Anticonvulsants; Chromatography, Gas; Chronic Disease; Disease Models, Animal; Dose-Respons | 2008 |
The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Injections, Intraperitoneal; | 2008 |
Febrile seizures in epileptic chicks: the effects of phenobarbital, phenytoin and valproate.
Topics: Animals; Chickens; Disease Models, Animal; Phenobarbital; Phenytoin; Reaction Time; Seizures, Febril | 1983 |
Effects of anticonvulsants on hyperthermia-induced seizures in the rat pup.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Temperature; Differential Threshold; Disease Model | 1984 |
Glycine potentiates the action of some anticonvulsant drugs in some seizure models.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Anticonvulsants; Disease Models, Animal; Dr | 1984 |
Variable patterns of malformation in the mouse fetal hydantoin syndrome.
Topics: Abnormalities, Multiple; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; | 1984 |
Penicillin spikes in rats. Limitations of a simple model for the study of anticonvulsants.
Topics: Action Potentials; Animals; Anticonvulsants; Dimethyl Sulfoxide; Disease Models, Animal; Drug Evalua | 1984 |
Stress ulcer accompanying subarachnoid hemorrhage--a new rat model.
Topics: Animals; Cimetidine; Diazepam; Disease Models, Animal; Gastric Mucosa; Male; Pentobarbital; Phenytoi | 1983 |
EEG quantification of drug level effects in monkey model of partial epilepsy.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Clonazepam; Disease Models, Animal; Electroencephalograp | 1982 |
A study of the action of anticonvulsant drugs on an experimental model of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Electric Stimulation; Epi | 1980 |
Quantitative histopathologic assessment of developing phenytoin-induced gingival overgrowth in the cat.
Topics: Animals; Cats; Connective Tissue; Disease Models, Animal; Female; Fibroblasts; Gingiva; Gingival Hyp | 1982 |
The role of dilantin in the prevention of pulmonary edema associated with cerebral hypoxia.
Topics: Animals; Brain; Disease Models, Animal; Dogs; Female; Hemorrhage; Hypoxia, Brain; Lung; Male; Perfus | 1982 |
Experimental automaticity induced by mechanical lesion in rat isolated right ventricle: the effects of quinidine, phenytoin, and propranolol.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Female; Male; Phenyto | 1982 |
Effect of antiepileptic drugs and an anticonvulsant on epileptiform activity induced by antibodies to ganglioside.
Topics: Action Potentials; Aminooxyacetic Acid; Animals; Anticonvulsants; Cobalt; Diazepam; Disease Models, | 1982 |
The effects of phenytoin on rat development: an animal model system for fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Female; Growth Disorders; Humans; Inte | 1981 |
The chick as a model for malignant hyperpyrexia.
Topics: Animals; Calcium; Chickens; Dantrolene; Disease Models, Animal; Drug Evaluation, Preclinical; Malign | 1980 |
Phenytoin-induced teratogenesis: a mouse model.
Topics: Animals; Disease Models, Animal; Epilepsy; Female; Mice; Mice, Neurologic Mutants; Phenytoin; Terato | 1981 |
Induction of cerebral thrombosis with phenytoin in rats.
Topics: Animals; Cerebral Arteries; Disease Models, Animal; Infusions, Intra-Arterial; Intracranial Embolism | 1995 |
Phenytoin delays ischemic depolarization, but cannot block its long-term consequences, in the rat hippocampal slice.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose; Hippocam | 1995 |
Anticonvulsant activity of Casimiroa edulis in comparison to phenytoin and phenobarbital.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Injections, Su | 1995 |
Anticonvulsant effect of intraventricular antiepileptic drugs. Experimental study.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Injections, Intraventricul | 1995 |
Aspirin and anticonvulsant interaction.
Topics: Animals; Aspirin; Carbamazepine; Disease Models, Animal; Drug Synergism; Electroshock; Female; Male; | 1995 |
A new, non-pharmacologic model of convulsive status epilepticus induced by electrical stimulation: behavioral/electroencephalographic observations and response to phenytoin and phenobarbital.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epi | 1994 |
Magnesium is more efficacious than phenytoin in reducing N-methyl-D-aspartate seizures in rats.
Topics: Animals; Disease Models, Animal; Female; Magnesium Sulfate; N-Methylaspartate; Phenytoin; Random All | 1994 |
Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Amino Acids, Cyclic; Analysis of Var | 1993 |
Pharmacological characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy.
Topics: Amino Acids; Aminocaproates; Amygdala; Animals; Anticonvulsants; Carbamazepine; Disease Models, Anim | 1993 |
Anticonvulsant efficacy and adverse effects of phenytoin during chronic treatment in amygdala-kindled rats.
Topics: Amygdala; Animals; Disease Models, Animal; Drug Administration Schedule; Female; Kindling, Neurologi | 1993 |
Neuroprotective properties of lifarizine compared with those of other agents in a mouse model of focal cerebral ischaemia.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, D | 1995 |
Effect of phenytoin on smoke inhalation injury in sheep.
Topics: Animals; Disease Models, Animal; Female; Hemodynamics; Myocardial Contraction; Phenytoin; Pulmonary | 1995 |
Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Phenobarbita | 1996 |
Pharmacology of cortical epileptic afterdischarges in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Dimethyl Sulfoxide; Disease Models, Animal | 1996 |
Increasing-current electroshock seizure test: a new method for assessment of anti- and pro-convulsant activities of drugs in mice.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Carbamazepine; Convulsants; Diazepam; Disease Models, | 1996 |
Influence of D-cycloserine on the anticonvulsant activity of phenytoin and carbamazepine against electroconvulsions in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Carbamazepine; Cycloserine; Disease | 1996 |
Infant monkey hyperexcitability after prenatal exposure to antiepileptic compounds.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Carbamazepine; Dioxolanes; Disease Mod | 1996 |
Phenytoin-induced cerebral thrombosis in rats: cerebral ultrastructure, water content and ischaemic volume in the acute phase.
Topics: Acute Disease; Animals; Arteries; Brain Edema; Brain Ischemia; Cerebral Cortex; Disease Models, Anim | 1996 |
Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy.
Topics: Animals; Anticonvulsants; Body Temperature; Calcium Channel Blockers; Disease Models, Animal; Electr | 1996 |
Susceptibility of isolated rat facial nerve to anaerobic stress.
Topics: Action Potentials; Anaerobiosis; Anesthetics, Local; Animals; Anticonvulsants; Cyanides; Disease Mod | 1997 |
Multifocal cerebral infarction induced by phenytoin in rats.
Topics: Animals; Cerebral Cortex; Cerebral Infarction; Disease Models, Animal; Intracranial Embolism and Thr | 1997 |
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain Stem; Disease Models, Animal; Dizocilpine Maleate; | 1997 |
AWD 140-190: a new anticonvulsant with a very good margin of safety.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; E | 1997 |
BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response R | 1997 |
Age-dependent phenytoin effects on cortical stimulation in rats.
Topics: Age Factors; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Electric Stimulation | 1998 |
Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Synergism; | 1998 |
Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Anticoagulants; Anti | 1998 |
Modelling of the pharmacodynamic interaction between phenytoin and sodium valproate.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interaction | 1998 |
Characterization of phenytoin-resistant kindled rats, a new model of drug-resistant partial epilepsy: influence of experimental and environmental factors.
Topics: Animals; Anticonvulsants; Atmospheric Pressure; Differential Threshold; Disease Models, Animal; Drug | 1999 |
Characterization of phenytoin-resistant kindled rats, a new model of drug-resistant partial epilepsy: influence of genetic factors.
Topics: Animals; Anticonvulsants; Differential Threshold; Disease Models, Animal; Drug Resistance; Electroph | 1999 |
Fosphenytoin reduces hippocampal neuronal damage in rat following transient global ischemia.
Topics: Analysis of Variance; Animals; Astrocytes; Cell Survival; Disease Models, Animal; Hippocampus; Ische | 1998 |
NMDA- but not kainate-mediated events reduce efficacy of some antiepileptic drugs against generalized tonic-clonic seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response Relationshi | 1999 |
Anticonvulsant activity of PNU-151774E in the amygdala kindled model of complex partial seizures.
Topics: Acetates; Alanine; Amines; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Benzylamines; Carba | 1999 |
Felbamate in experimental model of status epilepticus.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Dose-Response Relationshi | 2000 |
Phenytoin administration reveals a differential role of pontine reticular formation and periaqueductal gray neurons in generation of the convulsive behaviors of audiogenic seizures.
Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Reflex; Female; Male; | 2000 |
Anticonvulsant efficacy of topiramate in phenytoin-resistant kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Drug Resistance; Electric Stimulation; E | 2000 |
Anticonvulsant-induced suppression of IFN-gamma production by lymphocytes obtained from cervical lymph nodes in glioma-bearing mice.
Topics: Animals; Anticonvulsants; Brain; Brain Neoplasms; Disease Models, Animal; Glioma; Humans; Immunohist | 2000 |
Self-sustaining status epilepticus: a condition maintained by potentiation of glutamate receptors and by plastic changes in substance P and other peptide neuromodulators.
Topics: Age Factors; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electroencephalography; Ele | 2000 |
Effects of combined administration of zonisamide and valproic acid or phenytoin to nitric oxide production, monoamines and zonisamide concentrations in the brain of seizure-susceptible EL mice.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Interactions; Dru | 2000 |
Anticonvulsant effect of nimodipine alone and in combination with diazepam and phenytoin in a mouse model of status epilepticus.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Diazepam; Disease Models, Animal; Drug Therapy, | 2000 |
Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of acute phenytoin.
Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Brain; Disease Models, Animal; Dose-R | 2001 |
Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder.
Topics: Administration, Oral; Animals; Anticonvulsants; Bipolar Disorder; Brain; Carbamazepine; Disease Mode | 2002 |
Gamma hydroxybutyrate in the monkey. II. Effect of chronic oral anticonvulsant drugs.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epil | 1978 |
Suppression of decerebrate rigidity by phenytoin and chlorpromazine.
Topics: Animals; Cats; Chlorpromazine; Decerebrate State; Disease Models, Animal; Dose-Response Relationship | 1976 |
Prophylactic effects of phenytoin, phenobarbital, and carbamazepine examined in kindling cat preparations.
Topics: Animals; Carbamazepine; Cats; Disease Models, Animal; Drug Evaluation, Preclinical; Electric Stimula | 1976 |
A primate model for testing anticonvulsant drugs.
Topics: Allyl Compounds; Animals; Anticonvulsants; Carbamazepine; Chromatography, Gas; Diazepam; Disease Mod | 1975 |
Diphenylhydantoin induced gingival hyperplasia in ferrets: a precautionary note.
Topics: Animals; Disease Models, Animal; Ferrets; Gingival Hyperplasia; Gingivitis; Humans; Male; Phenytoin | 1979 |
Anticonvulsant osteomalacia induced in the rat by diphenylhydantoin.
Topics: Animals; Bone and Bones; Calcium; Disease Models, Animal; Ergocalciferols; Osteomalacia; Phenytoin; | 1978 |
Diphenylhydantoin gingival hyperplasia in Macaca arctoides: a new human model.
Topics: Adult; Animals; Dental Plaque; Disease Models, Animal; Female; Gingiva; Gingival Hyperplasia; Gingiv | 1977 |
Decreased binding of drugs and dyes to plasma proteins from rats with acute renal failure: effects of ureter ligation and intramuscular injection of glycerol.
Topics: Acute Kidney Injury; Animals; Blood Proteins; Coloring Agents; Creatinine; Disease Models, Animal; F | 1979 |
Clinical and experimental studies of phenytoin-induced hyperkinesias.
Topics: Aged; Animals; Apomorphine; Basal Ganglia; Corpus Striatum; Dextroamphetamine; Disease Models, Anima | 1979 |
The hippocampal slice: a system for studying the pharmacology of seizures and for screening anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Electroenc | 1977 |
Preliminary report on the magnesium deficient rat as a model of epilepsy.
Topics: Age Factors; Animals; Disease Models, Animal; Epilepsy; Female; Magnesium Deficiency; Male; Phenobar | 1978 |
Prophylaxis with diphenylhydantoin and phenobarbital and alumina-gel monkey model. I. Twelve months of treatment: seizure, EEG, blood, and behavioral data.
Topics: Aluminum Hydroxide; Animals; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; | 1976 |
Prophylaxis with diphenylhydantoin and phenobarbital in alumina-gel monkey model. II. Fourth-month follow-up period: seizure, EEG, blood and behavioral data.
Topics: Aluminum Hydroxide; Animals; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; | 1976 |
Acute anticonvulsant effects of diphenylhydantoin, phenobarbital, and carbamazepine: a combined electroclinical and serum level study in amygdaloid kindled cats and baboons.
Topics: Amygdala; Animals; Carbamazepine; Cats; Disease Models, Animal; Dose-Response Relationship, Drug; Dr | 1976 |
The photically evoked afterdischarge: a model for the study of drugs useful in the treatment of petit mal epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Absence; Evoked Potentials; Female; Pent | 1976 |
Control of ethanol withdrawal symptoms in mice by phenytoin.
Topics: Animals; Disease Models, Animal; Ethanol; Humans; Male; Mice; Pharmaceutical Vehicles; Phenytoin; Py | 1976 |
Relationship of drug metabolism and inflammation to the gingival response of rats treated with diphenylhydantoin.
Topics: Alveolar Process; Animals; Diet, Cariogenic; Disease Models, Animal; Female; Gingival Hyperplasia; G | 1975 |
The influence of aldosterone and anticonvulsant drugs on electroencephalographic and clinical disturbances induced by the spirolactone derivative, potassium canrenoate.
Topics: Aldosterone; Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Dogs; Electroencepha | 1975 |
Cerebral etiology of the acute respiratory distress syndrome: diphenylhydantoin prophylaxis.
Topics: Animals; Bronchial Diseases; Disease Models, Animal; Dogs; Female; Hypoxia, Brain; Lung; Male; Pheny | 1975 |
Photically induced epilepsy in Papio papio as a model for drug studies.
Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose- | 1975 |
Efficacy of standard anticonvulsants in monkey model with spontaneous motor seizures.
Topics: Aluminum; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Feeding Behavior | 1975 |
Response of generalized penicillin epilepsy in the cat to ethosuximide and diphenylhydantoin.
Topics: Animals; Cats; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinica | 1975 |
Fracture healing in rats treated with diphenylhydantoin (Dilantin).
Topics: Animals; Disease Models, Animal; Fibula; Fractures, Bone; Male; Phenytoin; Rats; Wound Healing | 1976 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Amin | 1991 |
Comparison of phenytoin with noncompetitive N-methyl-D-aspartate antagonists in a model of focal brain ischemia in rat.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Dizocilpine Maleate; Male; N-Methylaspartate; Phenc | 1990 |
Comparison of intraosseous versus intravenous loading of phenytoin in pigs and effect on bone marrow.
Topics: Animals; Bone Marrow; Child; Child, Preschool; Disease Models, Animal; Emergencies; Humans; Infusion | 1990 |
The fetal hydantoin syndrome: answers from a mouse model.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Disease Models, Animal; Embryo Implantation; Fema | 1989 |
[The effect of vanillin on the fully amygdala-kindled seizures in the rat].
Topics: Amygdala; Animals; Anticonvulsants; Benzaldehydes; Disease Models, Animal; Epilepsy; Female; Kindlin | 1989 |
Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Chlorpromazine; Diazepam; Disease Models, | 1986 |
U50,488, a highly selective kappa opioid: anticonvulsant profile in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; A | 1986 |
Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death.
Topics: Animals; Anti-Arrhythmia Agents; Body Weight; Bretylium Tosylate; Death, Sudden; Disease Models, Ani | 1986 |
Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Evaluation, Preclini | 1985 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M | 1985 |
Damage of Purkinje cell axons following chronic phenytoin administration: an animal model of distal axonopathy.
Topics: Animals; Axons; Central Nervous System Diseases; Disease Models, Animal; Epilepsy; Male; Mice; Mice, | 1985 |
Effects of diphenylhydantoin and cholinergic agents on the neuronally isolated cerebral cortex.
Topics: Animals; Atropine; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; | 1971 |
The effects of diphenylhydantoin, phenobarbital, and diazepam on the penicillin-induced epileptogenic focus in the rat.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Diazepam; Disease Models, Animal; Electroence | 1974 |
Brain synapses. An in vitro model for the study of seizures.
Topics: Adenosine Triphosphatases; Animals; Biological Transport; Brain; Disease Models, Animal; Electroence | 1972 |
Centrogenic cardiac arrhythmia induced by aconitine: a new "model" for screening of anti-arrhythmic drugs.
Topics: Adrenergic beta-Antagonists; Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood | 1971 |
The pattogenesis of submucous cleft palate.
Topics: Abnormalities, Drug-Induced; Animals; Cell Differentiation; Cleft Palate; Disease Models, Animal; Fe | 1974 |
Studies of immunoreactive insulin secretion in NZO mice in vivo.
Topics: Aminophylline; Animals; Antigens; Arginine; Diabetes Mellitus; Disease Models, Animal; Fasting; Gluc | 1974 |
Suppressant effects of diphenylhydantoin on the cortical epileptogenic focus.
Topics: Animals; Cats; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Electroencephalography | 1973 |
The anticonvulsant effects of phenobarbital, diphenylhydantoin and two benzodiazepines in the baboon, Papio papio.
Topics: Animals; Anticonvulsants; Benzazepines; Diazepam; Disease Models, Animal; Electrodes; Electroencepha | 1970 |
[Place of audiogenic convulsions among other convulsion models in assessing the anticonvulsive effect of pharmaceuticals].
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Mice; Phenytoi | 1972 |
Modification of experimental seizures and anticonvulsant efficacy by peripheral stimulation.
Topics: Animals; Cats; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Electroencephalography | 1971 |
Observations on models used for the evaluation of antiarrhythmic drugs.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutte | 1971 |