phenytoin has been researched along with Diathesis in 23 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The production of cleft palate by glucocorticoids and phenytoin is a complicated interference in a complex developmental program involving many genetic and biochemical processes." | 8.76 | Biochemical mechanism of glucocorticoid-and phenytoin-induced cleft palate. ( Goldman, AS, 1984) |
| "The present study was focused to characterize the effects of intrahippocampal application of R-verapamil, a P-glycoprotein blocker, and High Frequency Electrical Stimulation (HFS) at 130 Hz, on seizure susceptibility and extracellular concentrations of glutamate and γ-aminobutyric acid (GABA) in hippocampus of kindled rats with drug-resistant seizures." | 7.77 | Effects of high frequency electrical stimulation and R-verapamil on seizure susceptibility and glutamate and GABA release in a model of phenytoin-resistant seizures. ( Luna-Munguia, H; Orozco-Suarez, S; Rocha, L, 2011) |
| "Our previous genome-wide Quantitative Trait Locus (QTL) mapping study using mouse A/J by C57BL/6J recombinant inbred (RI) lines suggested several chromosomal regions contain genes influencing susceptibility to phenytoin (PT)-induced cleft lip with or without cleft palate [CL(P)] and 6-aminonicotinamide (6-AN)-induced isolated cleft palate (CP)." | 7.73 | Correlation of susceptibility to 6-aminonicotinamide and hydrocortisone-induced cleft palate. ( Diehl, SR; Erickson, RP; Karolyi, IJ, 2005) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 7.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| " Embryonic heart rate was also recorded on individual days after dosing days 9-16." | 5.31 | Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage. ( Azarbayjani, F; Danielsson, BR, 2001) |
| "The production of cleft palate by glucocorticoids and phenytoin is a complicated interference of a complex developmental program involving many genetic and biochemical processes." | 4.77 | Palatal development and the arachidonic acid cascade. ( Goldman, AS; Piddington, RL, 1985) |
| "The production of cleft palate by glucocorticoids and phenytoin is a complicated interference in a complex developmental program involving many genetic and biochemical processes." | 4.76 | Biochemical mechanism of glucocorticoid-and phenytoin-induced cleft palate. ( Goldman, AS, 1984) |
| "Evidence has been presented that there is a quantitative variation of fetal palatal glucocorticoid receptor levels which correlates with susceptibility to cortisone-induced cleft palate in a variety of inbred strains of mice." | 4.76 | Quantitative variation in hormonal receptors and clefting in the mouse. ( Goldman, AS; Katsumata, M, 1980) |
| " All had dermatological manifestations, eosinophilia and systemic (haematological and hepatic) manifestations that could be attributed to treatment with aromatic AEDs (carbamazepine, 2 patients; lamotrigine, 3 patients; phenytoin, 3 patients)." | 3.77 | Risk factors associated with DRESS syndrome produced by aromatic and non-aromatic antipiletic drugs. ( Kochen, S; Pereira de Silva, N; Piquioni, P; Saidon, P, 2011) |
| "The present study was focused to characterize the effects of intrahippocampal application of R-verapamil, a P-glycoprotein blocker, and High Frequency Electrical Stimulation (HFS) at 130 Hz, on seizure susceptibility and extracellular concentrations of glutamate and γ-aminobutyric acid (GABA) in hippocampus of kindled rats with drug-resistant seizures." | 3.77 | Effects of high frequency electrical stimulation and R-verapamil on seizure susceptibility and glutamate and GABA release in a model of phenytoin-resistant seizures. ( Luna-Munguia, H; Orozco-Suarez, S; Rocha, L, 2011) |
| "Our previous genome-wide Quantitative Trait Locus (QTL) mapping study using mouse A/J by C57BL/6J recombinant inbred (RI) lines suggested several chromosomal regions contain genes influencing susceptibility to phenytoin (PT)-induced cleft lip with or without cleft palate [CL(P)] and 6-aminonicotinamide (6-AN)-induced isolated cleft palate (CP)." | 3.73 | Correlation of susceptibility to 6-aminonicotinamide and hydrocortisone-induced cleft palate. ( Diehl, SR; Erickson, RP; Karolyi, IJ, 2005) |
| " We compare results obtained using phenytoin (which induces cleft lip) and 6-aminonicotinamide (which induces cleft palate)." | 3.69 | Genome scan for teratogen-induced clefting susceptibility loci in the mouse: evidence of both allelic and locus heterogeneity distinguishing cleft lip and cleft palate. ( Diehl, SR; Erickson, RP, 1997) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 3.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| "Inbred and congenic strains of mice have been studied for susceptibility to phenytoin-induced cleft lip with or without cleft palate (CLP) and isolated cleft palate (CP)." | 3.66 | Phenytoin teratogenicity in the primary and secondary mouse embryonic palate is influenced by the H-2 histocompatibility locus. ( Baker, MK; Fishman, CL; Goldman, AS, 1983) |
| " Embryonic heart rate was also recorded on individual days after dosing days 9-16." | 1.31 | Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage. ( Azarbayjani, F; Danielsson, BR, 2001) |
| "In rats aged 18 days or less ataxia of hindlimbs was also marked." | 1.27 | Convulsant action of diphenylhydantoin overdose in young rats. ( Lisková-Bernásková, K; Mares, P; Mudrochová, M, 1987) |
| "Phenytoin alone was not toxic to cells." | 1.26 | Predisposition to phenytoin hepatotoxicity assessed in vitro. ( Blake, DA; Goldstein, DA; Gordon, GB; Herlong, HF; Spielberg, SP, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (47.83) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Gando, I | 1 |
| Campana, C | 1 |
| Tan, RB | 1 |
| Cecchin, F | 1 |
| Sobie, EA | 1 |
| Coetzee, WA | 1 |
| Pereira de Silva, N | 1 |
| Piquioni, P | 1 |
| Kochen, S | 1 |
| Saidon, P | 1 |
| Luna-Munguia, H | 1 |
| Orozco-Suarez, S | 1 |
| Rocha, L | 1 |
| HOLLEY, HL | 1 |
| Erickson, RP | 3 |
| Karolyi, IJ | 2 |
| Diehl, SR | 2 |
| Goldman, AS | 4 |
| Spielberg, SP | 1 |
| Gordon, GB | 1 |
| Blake, DA | 1 |
| Goldstein, DA | 1 |
| Herlong, HF | 1 |
| Fishman, CL | 1 |
| Baker, MK | 1 |
| Katsumata, M | 1 |
| Jund, R | 1 |
| Kastenbauer, E | 1 |
| Azarbayjani, F | 1 |
| Danielsson, BR | 1 |
| Turski, W | 1 |
| Dziki, M | 1 |
| Parada, J | 1 |
| Kleinrok, Z | 1 |
| Cavalheiro, EA | 1 |
| Lindhout, D | 1 |
| Durner, M | 1 |
| Greenberg, DA | 1 |
| Delgado-Escueta, AV | 1 |
| Van Dyke, DC | 1 |
| Berg, MJ | 1 |
| Olson, CH | 1 |
| Hassell, TM | 1 |
| Crabbe, JC | 1 |
| Young, ER | 1 |
| Tam, B | 1 |
| Kosobud, A | 1 |
| Belknap, JK | 1 |
| Laursen, SE | 1 |
| Liu, S | 1 |
| Mares, P | 1 |
| Lisková-Bernásková, K | 1 |
| Mudrochová, M | 1 |
| Ebersole, JS | 1 |
| Chatt, AB | 1 |
| Piddington, RL | 1 |
| Farrell, G | 1 |
| Prendergast, D | 1 |
| Murray, M | 1 |
5 reviews available for phenytoin and Diathesis
| Article | Year |
|---|---|
Biochemical mechanism of glucocorticoid-and phenytoin-induced cleft palate.
Topics: Animals; Arachidonic Acids; Cell Survival; Chromosomes; Cleft Palate; Disease Susceptibility; Female | 1984 |
Quantitative variation in hormonal receptors and clefting in the mouse.
Topics: Animals; Cleft Palate; Cortisone; Dexamethasone; Disease Models, Animal; Disease Susceptibility; HLA | 1980 |
Is there a genetic relationship between epilepsy and birth defects?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Congenital Abnormalities; Dis | 1992 |
Differences in phenytoin biotransformation and susceptibility to congenital malformations: a review.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Disease Sus | 1991 |
Palatal development and the arachidonic acid cascade.
Topics: Animals; Arachidonic Acids; Cell Survival; Cleft Palate; Disease Susceptibility; Glucocorticoids; Mi | 1985 |
18 other studies available for phenytoin and Diathesis
| Article | Year |
|---|---|
A distinct molecular mechanism by which phenytoin rescues a novel long QT 3 variant.
Topics: Action Potentials; Amino Acid Substitution; Anti-Arrhythmia Agents; Cardiac Conduction System Diseas | 2020 |
Risk factors associated with DRESS syndrome produced by aromatic and non-aromatic antipiletic drugs.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anticonvulsants; Carbamazepine; Disease Susceptibility; | 2011 |
Effects of high frequency electrical stimulation and R-verapamil on seizure susceptibility and glutamate and GABA release in a model of phenytoin-resistant seizures.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Drug Resistance; Electric Stimulation; Extr | 2011 |
EVIDENCE FOR A PREDISPOSITION TO RHEUMATIC DISEASES IN FAMILIES OF PATIENTS DEVELOPING DRUG-INDUCED SYSTEMIC LUPUS ERYTHEMATOSUS.
Topics: Adolescent; Anticonvulsants; Child; Disease Susceptibility; Drug Therapy; Genetics, Medical; Humans; | 1964 |
Correlation of susceptibility to 6-aminonicotinamide and hydrocortisone-induced cleft palate.
Topics: 6-Aminonicotinamide; Animals; Cleft Palate; Disease Susceptibility; Female; Fetus; Hydrocortisone; M | 2005 |
Predisposition to phenytoin hepatotoxicity assessed in vitro.
Topics: Adult; Chemical and Drug Induced Liver Injury; Disease Susceptibility; Drug Hypersensitivity; Epoxid | 1981 |
Phenytoin teratogenicity in the primary and secondary mouse embryonic palate is influenced by the H-2 histocompatibility locus.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Disease Susceptibility; Female; H-2 A | 1983 |
Susceptibility of isolated rat facial nerve to anaerobic stress.
Topics: Action Potentials; Anaerobiosis; Anesthetics, Local; Animals; Anticonvulsants; Cyanides; Disease Mod | 1997 |
Genome scan for teratogen-induced clefting susceptibility loci in the mouse: evidence of both allelic and locus heterogeneity distinguishing cleft lip and cleft palate.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Alleles; Animals; Chromosome Mapping; Cleft Lip; C | 1997 |
Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bradycardia; Cleft Palate; Delayed Rectifier | 2001 |
Age dependency of the susceptibility of rats to aminooxyacetic acid seizures.
Topics: Aging; Aminooxyacetic Acid; Animals; Anticonvulsants; Body Temperature; Brain; Carbamazepine; Clonaz | 1992 |
Pharmacogenetics and drug interactions: role in antiepileptic-drug-induced teratogenesis.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Disease Susceptibility; Epilepsy; Epoxide Hydrolases; | 1992 |
Gingival overgrowth: hereditary considerations.
Topics: Disease Susceptibility; Family; Fibroblasts; Gingival Hyperplasia; Humans; Phenytoin; Twins | 1990 |
Genetic differences in anticonvulsant sensitivity in mouse lines selectively bred for ethanol withdrawal severity.
Topics: Alcohol Withdrawal Delirium; Alcohols; Animals; Anticonvulsants; Diazepam; Disease Susceptibility; E | 1986 |
Susceptibility to phenytoin-induced cleft lip with or without cleft palate: many genes are involved.
Topics: Animals; Cleft Lip; Cleft Palate; Disease Susceptibility; Mice; Mice, Inbred Strains; Phenytoin; Rec | 1987 |
Convulsant action of diphenylhydantoin overdose in young rats.
Topics: Animals; Animals, Newborn; Ataxia; Disease Susceptibility; Dose-Response Relationship, Drug; Male; P | 1987 |
Spread and arrest of seizures: the importance of layer 4 in laminar interactions during neocortical epileptogenesis.
Topics: Action Potentials; Animals; Anticonvulsants; Bicuculline; Biomechanical Phenomena; Cats; Cerebral Co | 1986 |
Halothane hepatitis. Detection of a constitutional susceptibility factor.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Disease Susceptibility; Drug Evaluation, Precli | 1985 |