phenytoin has been researched along with Delayed Effects, Prenatal Exposure in 69 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our objective was to evaluate the patterns of malformations in children exposed in utero to phenytoin (DPH) and carbamazepine (CBZ) monotherapy, and to compare them prospectively with matched mother-child pairs exposed to nonteratogens, and to separate the effects of antiepileptic drugs (AEDs) from those of epilepsy by collecting groups of untreated epileptics and those treated with DPH and CBZ for conditions other than epilepsy." | 9.08 | Findings in children exposed in utero to phenytoin and carbamazepine monotherapy: independent effects of epilepsy and medications. ( Chitayat, D; Farkas, LD; Koren, G; Nulman, I; Scolnik, D, 1997) |
| "We evaluated the causality of the association between intrauterine exposure to phenytoin and postnatal neuroblastoma using an in vitro lymphocyte toxicity assay for phenytoin-induced reactions in an unusual sibship." | 8.77 | Neuroblastoma after prenatal exposure to phenytoin: cause and effect? ( Demitrakoudis, D; Koren, G; Rieder, M; Shandling, B; Shear, NH; Sonely, M; Spielberg, SP; Weksberg, R, 1989) |
| "The aim of the present study was to test the hypothesis that the natural antioxidant melatonin (MEL) and the synthetic antioxidant stobadine (STO) could reduce the incidence of maternal and embryofoetal toxicity in rats due to intrauterine hypoxia." | 7.72 | Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration. ( Brucknerová, I; Dubovický, M; Juránek, I; Mach, M; Navarová, J; Soltés, L; Ujházy, E; Zeman, M, 2004) |
| "PHT dose-dependently increased the hypoxia staining (6- and 11-fold after maternal dosing of 100 and 150 mg/kg, respectively) during the period I(Kr) is expressed and functional (GD 10)." | 5.33 | Phenytoin teratogenicity: hypoxia marker and effects on embryonic heart rhythm suggest an hERG-related mechanism. ( Azarbayjani, F; Blomgren, B; Danielsson, BR; Danielsson, C; Johansson, A; Sköld, AC, 2005) |
| "In this prospective, observational, assessor-masked, multicentre study, we enrolled pregnant women with epilepsy on antiepileptic drug monotherapy (carbamazepine, lamotrigine, phenytoin, or valproate) between October, 1999, and February, 2004, at 25 epilepsy centres in the UK and the USA." | 5.17 | Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study. ( Baker, GA; Bromley, RL; Browning, N; Clayton-Smith, J; Cohen, MJ; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2013) |
| "Our objective was to evaluate the patterns of malformations in children exposed in utero to phenytoin (DPH) and carbamazepine (CBZ) monotherapy, and to compare them prospectively with matched mother-child pairs exposed to nonteratogens, and to separate the effects of antiepileptic drugs (AEDs) from those of epilepsy by collecting groups of untreated epileptics and those treated with DPH and CBZ for conditions other than epilepsy." | 5.08 | Findings in children exposed in utero to phenytoin and carbamazepine monotherapy: independent effects of epilepsy and medications. ( Chitayat, D; Farkas, LD; Koren, G; Nulman, I; Scolnik, D, 1997) |
| "The developmental neurotoxicity of phenytoin, isotretinoin, and methamphetamine has been reviewed to illustrate effects from both therapeutic and illicit drugs to which people are exposed and which either induce or show the potential for inducing learning disabilities following in utero exposure." | 4.79 | Developmental neurotoxicity induced by therapeutic and illicit drugs. ( Vorhees, CV, 1994) |
| "We evaluated the causality of the association between intrauterine exposure to phenytoin and postnatal neuroblastoma using an in vitro lymphocyte toxicity assay for phenytoin-induced reactions in an unusual sibship." | 4.77 | Neuroblastoma after prenatal exposure to phenytoin: cause and effect? ( Demitrakoudis, D; Koren, G; Rieder, M; Shandling, B; Shear, NH; Sonely, M; Spielberg, SP; Weksberg, R, 1989) |
| "The "anticonvulsant face," with a short nose, broad nasal bridge, epicanthal folds, and wide mouth, was described in the 1970s in children who had been exposed during pregnancy to the anticonvulsant drugs phenytoin and phenobarbital." | 3.80 | Laser light scan analysis of the "anticonvulsant face". ( Deutsch, CK; Holmes, LB; Orup, HI, 2014) |
| "Between 1999 and 2004, we enrolled pregnant women with epilepsy who were taking a single antiepileptic agent (carbamazepine, lamotrigine, phenytoin, or valproate) in a prospective, observational, multicenter study in the United States and the United Kingdom." | 3.75 | Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. ( Baker, GA; Browning, N; Clayton-Smith, J; Cohen, M; Combs-Cantrell, DT; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2009) |
| "(1) Numerous follow-up studies of pregnancies in women with epilepsy show that valproic acid is more teratogenic than other antiepileptics." | 3.75 | Valproic acid: long-term effects on children exposed in utero. ( , 2009) |
| "Children exposed during pregnancy to the anticonvulsant drugs phenytoin, phenobarbital, and carbamazepine as monotherapy and polytherapy have an increased frequency of midface and digit hypoplasia." | 3.73 | The correlation of deficits in IQ with midface and digit hypoplasia in children exposed in utero to anticonvulsant drugs. ( Coull, BA; Dorfman, J; Holmes, LB; Rosenberger, PB, 2005) |
| " The AEDs received by the mothers with epilepsy were Phenytoin, Carbamazepine, and Sodium valproate." | 3.73 | Physical growth and psychomotor development of infants exposed to antiepileptic drugs in utero. ( Arulmozhi, T; Dhanaraj, M; Rangaraj, R; Vengatesan, A, 2006) |
| "The aim of the present study was to test the hypothesis that the natural antioxidant melatonin (MEL) and the synthetic antioxidant stobadine (STO) could reduce the incidence of maternal and embryofoetal toxicity in rats due to intrauterine hypoxia." | 3.72 | Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration. ( Brucknerová, I; Dubovický, M; Juránek, I; Mach, M; Navarová, J; Soltés, L; Ujházy, E; Zeman, M, 2004) |
| "To compare pregnancy outcome prospectively after phenytoin and carbamazepine monotherapy with outcome in matched mother-child pairs exposed to nonteratogens to evaluate the relative fetal safety of these drugs." | 3.69 | Neurodevelopment of children exposed in utero to phenytoin and carbamazepine monotherapy. ( Ashby, P; Czuchta, D; Einarson, T; Gardner, HA; Gladstone, D; Gladstone, R; Nulman, I; Rovet, J; Scolnik, D; Weksberg, R, 1994) |
| "There is evidence that vitamin K-deficiency during human pregnancy can be caused by the therapeutic use of warfarin or phenytoin." | 3.68 | Binder's syndrome due to prenatal vitamin K deficiency: a theory of pathogenesis. ( Halliday, JL; Howe, AM; Lipson, AH; Sheffield, LJ; Webster, WS, 1992) |
| " Fifty-two children had been exposed to phenytoin monotherapy, 19 to carbamazepine monotherapy, 27 to drug combinations including barbiturates, 29 to other drug combinations, and 17 children had not been exposed to antiepileptic drugs (AEDs) during pregnancy." | 3.68 | Head circumference in children of epileptic mothers: contributions of drug exposure and genetic background. ( Bardy, AH; Gaily, EK; Granström, ML; Hiilesmaa, VK, 1990) |
| " However, mothers who had one affected child appeared to be at much higher risk for having subsequent affected children (9 of 10) if phenytoin use was continued through future pregnancies than were mothers whose first-born child was unaffected despite being exposed to phenytoin during the pregnancy (5 of 52 among all families, or 1 of 48 when only children exposed throughout the entire pregnancy were included)." | 3.67 | Family studies in fetal phenytoin exposure. ( Heide, F; Hill, LR; Hodge, SE; Van Dyke, DC, 1988) |
| "Epilepsy affects fetal brain development during gestation in pregnant rats, therefore anti-epileptic therapy should be continued during pregnancy." | 2.53 | Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats. ( Doğan, Z; Kamışlı, Ö; Soysal, H, 2016) |
| "PHT dose-dependently increased the hypoxia staining (6- and 11-fold after maternal dosing of 100 and 150 mg/kg, respectively) during the period I(Kr) is expressed and functional (GD 10)." | 1.33 | Phenytoin teratogenicity: hypoxia marker and effects on embryonic heart rhythm suggest an hERG-related mechanism. ( Azarbayjani, F; Blomgren, B; Danielsson, BR; Danielsson, C; Johansson, A; Sköld, AC, 2005) |
| "The aim of this study was to test the effect of supranutritional dosage of the natural antioxidant vitamin E (VitE) on phenytoin (PHT) induced developmental toxicity and possible long-term effects in rat offspring." | 1.33 | Vitamin E supplementation in phenytoin induced developmental toxicity in rats: postnatal study. ( Dubovický, M; Kovacovský, P; Mach, M; Navarová, J; Ujházy, E, 2006) |
| "Fluconazole (FCZ) is a potent inhibitor of the cytochrome P450 (CYP)-mediated metabolism of the anti-epileptic agent phenytoin (PHT), a well-known human and animal teratogen." | 1.32 | Additional investigation on the potentiation of phenytoin teratogenicity by fluconazole. ( Angelucci, S; Bellati, U; Di Ilio, C; Giampietro, F; Moio, P; Tiboni, GM, 2003) |
| "Phenytoin (PHT) is an antiepileptic drug known to have teratogenic effects." | 1.32 | Effect of prenatal phenytoin administration on the fine structure of rat myocardium and aorta. ( Dubovický, M; Guller, L; Mach, M; Okruhlicová, L; Sotníková, R; Tribulová, N; Ujházy, E, 2003) |
| "Cerebral palsy was not diagnosed in any infant of a hypertensive mother compared with five of the controls." | 1.30 | Maternal hypertension and neurodevelopmental outcome in very preterm infants. ( Burns, YR; Gray, PH; King, JF; Mohay, HA; O'Callaghan, MJ, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (34.78) | 18.7374 |
| 1990's | 16 (23.19) | 18.2507 |
| 2000's | 19 (27.54) | 29.6817 |
| 2010's | 8 (11.59) | 24.3611 |
| 2020's | 2 (2.90) | 2.80 |
| Authors | Studies |
|---|---|
| Bromley, R | 1 |
| Adab, N | 1 |
| Bluett-Duncan, M | 1 |
| Clayton-Smith, J | 4 |
| Christensen, J | 1 |
| Edwards, K | 1 |
| Greenhalgh, J | 1 |
| Hill, RA | 1 |
| Jackson, CF | 1 |
| Khanom, S | 1 |
| McGinty, RN | 1 |
| Tudur Smith, C | 1 |
| Pulman, J | 1 |
| Marson, AG | 1 |
| Kakumoto, M | 1 |
| Shimokawa, K | 1 |
| Ueshima, S | 1 |
| Hira, D | 1 |
| Okano, T | 1 |
| Cohen, MJ | 2 |
| Meador, KJ | 4 |
| May, R | 1 |
| Loblein, H | 1 |
| Conrad, T | 1 |
| Baker, GA | 3 |
| Bromley, RL | 2 |
| Kalayjian, LA | 3 |
| Kanner, A | 3 |
| Liporace, JD | 3 |
| Pennell, PB | 3 |
| Privitera, M | 3 |
| Loring, DW | 4 |
| Babu, S | 1 |
| Agarwal, N | 1 |
| Verrotti, A | 1 |
| Scaparrotta, A | 1 |
| Cofini, M | 1 |
| Chiarelli, F | 1 |
| Tiboni, GM | 2 |
| Orup, HI | 2 |
| Deutsch, CK | 1 |
| Holmes, LB | 4 |
| Soysal, H | 2 |
| Doğan, Z | 1 |
| Kamışlı, Ö | 1 |
| Hirashima, R | 1 |
| Michimae, H | 1 |
| Takemoto, H | 1 |
| Sasaki, A | 1 |
| Kobayashi, Y | 1 |
| Itoh, T | 1 |
| Tukey, RH | 1 |
| Fujiwara, R | 1 |
| Browning, N | 2 |
| Combs-Cantrell, DT | 1 |
| Cohen, M | 1 |
| Unur, E | 1 |
| Düzler, A | 1 |
| Karaca, O | 1 |
| Ekinci, N | 1 |
| Bokhari, A | 1 |
| Coull, BA | 3 |
| Ogura, H | 1 |
| Yasuda, M | 1 |
| Nakamura, S | 1 |
| Yamashita, H | 1 |
| Mikoshiba, K | 1 |
| Ohmori, H | 1 |
| Keith, DA | 3 |
| Giampietro, F | 1 |
| Angelucci, S | 1 |
| Moio, P | 1 |
| Bellati, U | 1 |
| Di Ilio, C | 1 |
| Okruhlicová, L | 1 |
| Ujházy, E | 4 |
| Mach, M | 3 |
| Sotníková, R | 1 |
| Tribulová, N | 1 |
| Guller, L | 1 |
| Dubovický, M | 4 |
| Kovacovský, P | 2 |
| Navarová, J | 3 |
| Juráni, M | 1 |
| Soltés, L | 2 |
| Juránek, I | 1 |
| Brucknerová, I | 1 |
| Zeman, M | 1 |
| Shorvon, SD | 1 |
| Dorfman, J | 1 |
| Rosenberger, PB | 1 |
| Danielsson, BR | 1 |
| Johansson, A | 1 |
| Danielsson, C | 1 |
| Azarbayjani, F | 1 |
| Blomgren, B | 1 |
| Sköld, AC | 1 |
| Webster, WS | 3 |
| Howe, AM | 3 |
| Abela, D | 1 |
| Oakes, DJ | 1 |
| Arulmozhi, T | 1 |
| Dhanaraj, M | 1 |
| Rangaraj, R | 1 |
| Vengatesan, A | 1 |
| Mowery, TM | 1 |
| McDowell, AL | 1 |
| Garraghty, PE | 1 |
| Koch, S | 2 |
| Göpfert-Geyer, I | 1 |
| Jäger-Roman, E | 2 |
| Jakob, S | 1 |
| Huth, H | 1 |
| Hartmann, A | 1 |
| Rating, D | 2 |
| Helge, H | 2 |
| Sonawane, BR | 1 |
| Yaffe, SJ | 1 |
| Guzmán Toledano, R | 1 |
| Coeto Anaya, H | 1 |
| Bostrom, B | 1 |
| Nesbit, ME | 1 |
| Patsalos, PN | 1 |
| Wiggins, RC | 1 |
| Skalko, RG | 1 |
| Kwasigroch, TE | 1 |
| Mullenix, P | 1 |
| Tassinari, MS | 2 |
| Ikeda, H | 1 |
| Scolnik, D | 2 |
| Nulman, I | 2 |
| Rovet, J | 1 |
| Gladstone, D | 1 |
| Czuchta, D | 1 |
| Gardner, HA | 1 |
| Gladstone, R | 1 |
| Ashby, P | 1 |
| Weksberg, R | 2 |
| Einarson, T | 1 |
| Jeret, JS | 1 |
| Thompson, WO | 1 |
| Yu, WK | 1 |
| Wells, PG | 1 |
| Vorhees, CV | 3 |
| Chhabra, RS | 1 |
| Bucher, JR | 1 |
| Haseman, JK | 1 |
| Elwell, MR | 1 |
| Kurtz, PJ | 1 |
| Carlton, BD | 1 |
| Lipson, AH | 2 |
| Sheffield, LJ | 2 |
| Haan, EA | 1 |
| Halliday, JL | 2 |
| Jenson, F | 1 |
| David, DJ | 1 |
| Lösche, G | 1 |
| Nau, H | 1 |
| Phillips, NK | 1 |
| Lockard, JS | 1 |
| Murray, JC | 1 |
| Hill, RM | 1 |
| Hegemier, S | 1 |
| Hurwitz, RL | 1 |
| Chitayat, D | 1 |
| Farkas, LD | 1 |
| Koren, G | 2 |
| Gray, PH | 1 |
| O'Callaghan, MJ | 1 |
| Mohay, HA | 1 |
| Burns, YR | 1 |
| King, JF | 1 |
| Dessens, AB | 2 |
| Cohen-Kettenis, PT | 2 |
| Mellenbergh, GJ | 2 |
| vd Poll, N | 1 |
| Koppe, JG | 2 |
| Boer, K | 2 |
| van De Poll, NE | 1 |
| Laskowska, M | 1 |
| Leszczyńska-Gorzelak, B | 1 |
| Oleszczuk, J | 1 |
| Wide, K | 1 |
| Henning, E | 1 |
| Tomson, T | 1 |
| Winbladh, B | 1 |
| Rindler, JM | 1 |
| Minck, DR | 1 |
| Gaily, EK | 1 |
| Granström, ML | 2 |
| Hiilesmaa, VK | 1 |
| Bardy, AH | 1 |
| Gaily, E | 1 |
| Kantola-Sorsa, E | 1 |
| Nanda, A | 1 |
| Kaur, S | 1 |
| Bhakoo, ON | 1 |
| Kapoor, MM | 1 |
| Kanwar, AJ | 1 |
| Demitrakoudis, D | 1 |
| Rieder, M | 1 |
| Shear, NH | 1 |
| Sonely, M | 1 |
| Shandling, B | 1 |
| Spielberg, SP | 1 |
| Mullenix, PJ | 1 |
| Kernan, WJ | 1 |
| Zengel, AE | 1 |
| Durá, T | 1 |
| Moya, M | 1 |
| Muñoz, M | 1 |
| Juste, M | 1 |
| Castaño, C | 1 |
| Van Dyke, DC | 2 |
| Hodge, SE | 1 |
| Heide, F | 1 |
| Hill, LR | 1 |
| Goldman, AS | 1 |
| Gupta, C | 1 |
| Katsumata, M | 1 |
| Shapiro, BH | 3 |
| Babalola, GO | 1 |
| Lech, GM | 2 |
| Bardales, RM | 2 |
| Takagi, S | 1 |
| Alleva, FR | 1 |
| Seth, PK | 1 |
| Balazs, T | 1 |
| Sholler, GF | 1 |
| Hawker, RE | 1 |
| Nunn, GR | 1 |
| Bale, P | 1 |
| Bergin, M | 1 |
| Niebyl, JR | 1 |
| Blake, DA | 1 |
| Rocco, LE | 1 |
| Baumgardner, R | 1 |
| Mellits, ED | 1 |
| Royer, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neurodevelopmental Effects of Antiepileptic Drugs II: the NEAD Study[NCT00021866] | 331 participants (Actual) | Observational | 2000-09-30 | Completed | |||
| Effects and Consequences for Mother and Child From Treatment for Depression, A Prospective Randomized, Placebo- Controlled, Trial With Internet-based Cognitive Behavior Therapy and Sertraline or Placebo for Moderate Depression in Pregnancy[NCT02185547] | Phase 4 | 17 participants (Actual) | Interventional | 2016-02-21 | Terminated (stopped due to Difficulties in recruiting participants.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for phenytoin and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child.
Topics: Child; Cohort Studies; Epilepsy; Female; Humans; Lamotrigine; Male; Phenytoin; Pregnancy; Prenatal E | 2023 |
Developmental neurotoxicity and anticonvulsant drugs: a possible link.
Topics: Animals; Anticonvulsants; Breast Feeding; Carbamazepine; Cognition Disorders; Developmental Disabili | 2014 |
Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Disease Models, Animal; Electroencephal | 2016 |
Effects of intraperitoneal administration of the phenytoin on the skeletal system of rat fetus.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Body Weight; Bone and Bones; Embryo, Mammalia | 2011 |
The relationship between cleft lip, maxillary hypoplasia, hypoxia and phenytoin.
Topics: Animals; Anticonvulsants; Cleft Lip; Female; Fetal Hypoxia; Humans; Maxilla; Organogenesis; Phenytoi | 2006 |
Developmental neurotoxicity induced by therapeutic and illicit drugs.
Topics: Animals; Brain Diseases; Female; Humans; Illicit Drugs; Isotretinoin; Learning Disabilities; Methamp | 1994 |
Prenatal exposure to phenytoin, facial development, and a possible role for vitamin K.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Child; Chondrodysplasia Punctata; Face; Female; | 1995 |
Lymphoblastic lymphoma following prenatal exposure to phenytoin.
Topics: Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Phenytoin; | 1996 |
Neuroblastoma after prenatal exposure to phenytoin: cause and effect?
Topics: Bone and Bones; Female; Humans; Lymphocytes; Male; Neuroblastoma; Phenytoin; Pregnancy; Prenatal Exp | 1989 |
5 trials available for phenytoin and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study.
Topics: Adult; Anticonvulsants; Child; Child Development; Child, Preschool; Cognition; Epilepsy; Female; Hum | 2013 |
[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and child development].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Akathisia, Drug-Induced; Anencephaly; Ant | 1983 |
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System | 1996 |
Findings in children exposed in utero to phenytoin and carbamazepine monotherapy: independent effects of epilepsy and medications.
Topics: Adult; Carbamazepine; Cohort Studies; Craniofacial Abnormalities; Epilepsy; Female; Fingers; Humans; | 1997 |
[Evaluation of antiepileptic therapy during pregnancy].
Topics: Adult; Anticonvulsants; Apgar Score; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenobarbi | 2002 |
55 other studies available for phenytoin and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Effects of antiepileptic drugs' administration during pregnancy on the nerve cell proliferation and axonal outgrowth of human neuroblastoma SH-SY5Y nerve cells.
Topics: Anticonvulsants; Carbamazepine; Cell Line, Tumor; Cell Proliferation; Child; Epilepsy; Female; Human | 2021 |
Fetal antiepileptic drug exposure and learning and memory functioning at 6 years of age: The NEAD prospective observational study.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Lamotrigine; Learning; Memor | 2019 |
Anonychia due to prenatal phenytoin exposure.
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Nails, Malformed; Phenytoin; Pregnancy; Pregnancy | 2012 |
Laser light scan analysis of the "anticonvulsant face".
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Case-Control Studies; Child; Cohort Studie | 2014 |
Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity.
Topics: Animals; Animals, Newborn; Brain; Carbamazepine; Cell Movement; Enzyme Induction; Female; Gene Expre | 2016 |
Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Child, Preschool; Cognition; Developmental Disabilities; Dose | 2009 |
Valproic acid: long-term effects on children exposed in utero.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Contraindications; Dose | 2009 |
Effect of prenatal exposure to anticonvulsant drugs on dermal ridge patterns of fingers.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Dermatogly | 2002 |
Neurotoxic damage of granule cells in the dentate gyrus and the cerebellum and cognitive deficit following neonatal administration of phenytoin in mice.
Topics: Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Body Weight; Cerebellum; Cognition Disorders; | 2002 |
Craniofacial skeletal deviations following in utero exposure to the anticonvulsant phenytoin: monotherapy and polytherapy.
Topics: Abnormalities, Drug-Induced; Adolescent; Age Determination by Skeleton; Age Determination by Teeth; | 2003 |
Additional investigation on the potentiation of phenytoin teratogenicity by fluconazole.
Topics: Animals; Chromatography, High Pressure Liquid; Cleft Palate; Dose-Response Relationship, Drug; Drug | 2003 |
Effect of prenatal phenytoin administration on the fine structure of rat myocardium and aorta.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anticonvulsants; Aorta, Thoracic; Female | 2003 |
Effect of melatonin on neurobehavioral dysfunctions induced by intrauterine hypoxia in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Female; Hypoxia; Melatonin; Oxidative Stress; Pheny | 2004 |
Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration.
Topics: Abnormalities, Drug-Induced; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Body | 2004 |
Longer term outcome of children born to mothers with epilepsy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Fema | 2004 |
The correlation of deficits in IQ with midface and digit hypoplasia in children exposed in utero to anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Face; Facie | 2005 |
Phenytoin teratogenicity: hypoxia marker and effects on embryonic heart rhythm suggest an hERG-related mechanism.
Topics: Animals; Anticonvulsants; Cation Transport Proteins; Ether-A-Go-Go Potassium Channels; Female; Heart | 2005 |
Physical growth and psychomotor development of infants exposed to antiepileptic drugs in utero.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Growth; Humans; Infant; Maternal Age; Motor Activity; Pari | 2006 |
Vitamin E supplementation in phenytoin induced developmental toxicity in rats: postnatal study.
Topics: Animals; Animals, Newborn; Dietary Supplements; Female; Fetal Hypoxia; Fetal Viability; Growth and D | 2006 |
Chronic developmental exposure to phenytoin has long-term behavioral consequences.
Topics: Animals; Animals, Newborn; Anticonvulsants; Appetitive Behavior; Avoidance Learning; Behavior, Anima | 2008 |
Delayed effects of drug exposure during pregnancy: reproductive function.
Topics: Animals; Anticonvulsants; Estrus; Female; Fertility; Luteinizing Hormone; Male; Phenobarbital; Pheny | 1983 |
[Epilepsy, anticonvulsants and pregnancy].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications | 1984 |
Hodgkin disease in a child with fetal alcohol-hydantoin syndrome.
Topics: Child, Preschool; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Hodgkin Disease; Humans; Phenyt | 1983 |
Brain maturation following administration of phenobarbital, phenytoin, and sodium valproate to developing rats or to their dams: effects on synthesis of brain myelin and other subcellular membrane proteins.
Topics: Animals; Anticonvulsants; Brain; Female; Intracellular Membranes; Membrane Proteins; Myelin Proteins | 1982 |
The interaction of chemicals during pregnancy: an update.
Topics: Abnormalities, Drug-Induced; Animals; Bromodeoxyuridine; Caffeine; Drug Interactions; Female; Fetus; | 1983 |
Behavioral outcome after prenatal exposure to phenytoin in rats.
Topics: Aging; Animals; Behavior, Animal; Body Weight; Female; Learning; Motor Activity; Phenytoin; Pregnanc | 1983 |
[Pharmacological studies on the functional development of the central nervous system in first generation rats born to phenytoin-treated mothers (author's transl)].
Topics: Animals; Animals, Newborn; Ataxia; Birth Rate; Brain; Catalepsy; Diazepam; Eye; Feeding Behavior; Fe | 1982 |
Neurodevelopment of children exposed in utero to phenytoin and carbamazepine monotherapy.
Topics: Carbamazepine; Case-Control Studies; Child; Cognition; Developmental Disabilities; Female; Humans; I | 1994 |
Neurodevelopment after in utero exposure to phenytoin and carbamazepine.
Topics: Carbamazepine; Child; Developmental Disabilities; Female; Humans; Phenytoin; Pregnancy; Prenatal Exp | 1994 |
Neurodevelopment after in utero exposure to phenytoin and carbamazepine.
Topics: Carbamazepine; Child; Developmental Disabilities; Female; Humans; Phenytoin; Pregnancy; Prenatal Exp | 1994 |
Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Abnormalities, Drug-Induced; Animals; Biotransformation; Catalysis; | 1995 |
Comparative carcinogenicity of 5,5-diphenylhydantoin with or without perinatal exposure in rats and mice.
Topics: Adenoma, Liver Cell; Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Female; Fetal Dea | 1993 |
Infant monkey hyperexcitability after prenatal exposure to antiepileptic compounds.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Carbamazepine; Dioxolanes; Disease Mod | 1996 |
Maternal hypertension and neurodevelopmental outcome in very preterm infants.
Topics: Adult; Anticonvulsants; Antihypertensive Agents; Case-Control Studies; Cerebral Palsy; Child, Presch | 1998 |
Prenatal exposure to anticonvulsants and psychosexual development.
Topics: Anticonvulsants; Cross-Sectional Studies; Female; Follow-Up Studies; Gender Identity; Humans; Male; | 1999 |
Association of prenatal phenobarbital and phenytoin exposure with small head size at birth and with learning problems.
Topics: Adult; Anticonvulsants; Cephalometry; Cognition; Cross-Sectional Studies; Epilepsy; Female; Follow-U | 2000 |
Psychomotor development in preschool children exposed to antiepileptic drugs in utero.
Topics: Anticonvulsants; Child, Preschool; Female; Humans; Longitudinal Studies; Male; Maternal-Fetal Exchan | 2002 |
Binder's syndrome due to prenatal vitamin K deficiency: a theory of pathogenesis.
Topics: Adolescent; Alcoholism; Aneurysm, Ruptured; Animals; Cartilage; Child, Preschool; Female; Humans; In | 1992 |
Effects of exposure period and nutrition on the developmental neurotoxicity of anticonvulsants in rats: short and long-term effects.
Topics: Animal Nutritional Physiological Phenomena; Animals; Anticonvulsants; Female; Male; Manganese; Nervo | 1990 |
Head circumference in children of epileptic mothers: contributions of drug exposure and genetic background.
Topics: Adult; Anticonvulsants; Carbamazepine; Child, Preschool; Epilepsy; Female; Humans; Intelligence Test | 1990 |
Intelligence of children of epileptic mothers.
Topics: Child, Preschool; Developmental Disabilities; Epilepsy; Female; Humans; Intelligence; Intelligence T | 1988 |
Fetal hydantoin syndrome: a case report.
Topics: Abnormalities, Drug-Induced; Diagnosis, Differential; Epilepsy, Tonic-Clonic; Face; Female; Fingers; | 1989 |
Extension of the analysis of the time structure of behavioral acts.
Topics: Animals; Behavior, Animal; Female; Male; Nitrous Oxide; Phenytoin; Pregnancy; Prenatal Exposure Dela | 1989 |
Prenatal exposure to phenytoin and its effect on postnatal growth and craniofacial proportion in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone Development; Eye Abnormalities; Face; Female | 1989 |
[Combination of hydantoins and valproate. Evidence of its teratogenic effect in 4 consecutive gestations].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Drug Therapy, Combina | 1986 |
Family studies in fetal phenytoin exposure.
Topics: Abnormalities, Drug-Induced; Child; Embryonic and Fetal Development; Family; Fathers; Female; Humans | 1988 |
Elevated glucocorticoid receptor levels in lymphocytes of children with the fetal hydantoin syndrome (FHS).
Topics: Abnormalities, Drug-Induced; Child; Female; Fetal Diseases; Humans; Hydantoins; Lymphocytes; Phenyto | 1987 |
Fetal anticonvulsant exposure: effects on behavioral and physical development.
Topics: Animals; Anticonvulsants; Female; Humans; Learning; Memory; Motor Activity; Oxazoles; Phenobarbital; | 1986 |
Developmental profile of serum androgens and estrous cyclicity of male and female rats exposed, perinatally, to maternally administered phenytoin.
Topics: Androgens; Animals; Body Weight; Dose-Response Relationship, Drug; Estrus; Female; Fetus; Male; Phen | 1987 |
Persistent defects in the hepatic monooxygenase system of adult rats exposed, perinatally, to maternally administered phenytoin.
Topics: Aminopyrine N-Demethylase; Animals; Body Weight; Female; Kinetics; Liver; Male; Microsomes, Liver; M | 1986 |
Delayed development of reproductive functions and alteration of dopamine receptor binding in hypothalamus of rats exposed prenatally to phenytoin and phenobarbital.
Topics: Animals; Female; Hypothalamus; Male; Phenobarbital; Phenytoin; Pregnancy; Prenatal Exposure Delayed | 1986 |
Primary left ventricular rhabdomyosarcoma in a child: noninvasive assessment and successful resection of a rare tumor.
Topics: Child, Preschool; Echocardiography; Female; Heart Neoplasms; Heart Ventricles; Humans; Phenytoin; Pr | 1987 |
Lack of maternal metabolic, endocrine, and environmental influences in the etiology of cleft lip with or without cleft palate.
Topics: Adult; Cleft Lip; Cleft Palate; Drug Interactions; Endocrine Glands; Erythrocytes; Female; Folic Aci | 1985 |
[Postnatal effects of intrauterine chemical stress].
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Dyskinesia, Drug-Induced; Failure to Thrive; Female; Fet | 1985 |
Perinatal induction of hepatic aminopyrine N-demethylase by maternal exposure to phenytoin.
Topics: Aminopyrine N-Demethylase; Animals; Animals, Newborn; Body Weight; Enzyme Induction; Female; Kinetic | 1985 |