phenytoin has been researched along with Critical Illness in 25 studies
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "How aggressively these seizures should be treated is unclear." | 6.52 | Lacosamide in status epilepticus: Update on the TRENdS study. ( Husain, AM, 2015) |
| "Sixty critically ill pediatric patients receiving phenytoin for treatment of seizures in a large multidisciplinary intensive care unit." | 3.73 | Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children. ( Dodson, B; McClain, CD; McManus, ML; Wolf, GK; Zurakowski, D, 2006) |
| "Because hypoalbuminemia is common in the ICU setting, inappropriate ordering of serum albumin levels may lead to unnecessary albumin administration or excessive macronutrient administration in nutritional regimens, leading to possible adverse effects and added costs." | 2.72 | Serum Albumin Levels: Who Needs Them? ( Erstad, BL, 2021) |
| " Modifying dosing according to SIRS will improve the prediction accuracy of drug concentration based on TDM." | 2.55 | [Evaluation of Pharmacotherapy on Emergency and Intensive Care Medicine: The Influence of Intensity and Duration of Invasion]. ( Imai, T, 2017) |
| "The aim of this review was to evaluate current literature for dosing recommendations for the use of antiepileptic medications in patients receiving renal replacement therapy (RRT)." | 2.53 | Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. ( Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS, 2016) |
| "How aggressively these seizures should be treated is unclear." | 2.52 | Lacosamide in status epilepticus: Update on the TRENdS study. ( Husain, AM, 2015) |
| " Case reports describe phenytoin toxicity secondary to inappropriate dosage adjustments based solely on total serum concentrations in patients with hypoalbuminemia." | 2.44 | Therapeutic drug monitoring of phenytoin in critically ill patients. ( Spriet, I; von Winckelmann, SL; Willems, L, 2008) |
| " The objectives of this study are to develop an ex-vivo in-vivo correlation (EVIVC) model to predict drug clearance for commonly used antiepileptics and to evaluate similarity in drug extraction across different CRRT modalities to extrapolate dosing recommendations." | 1.72 | Development and Use of an Ex-Vivo In-Vivo Correlation to Predict Antiepileptic Drug Clearance in Patients Undergoing Continuous Renal Replacement Therapy. ( Armahizer, M; Badjatia, N; Gobburu, JV; Gopalakrishnan, M; Kalaria, SN; McCarthy, P, 2022) |
| "Phenytoin has a narrow therapeutic index and the potential of under-treatment or toxicity." | 1.56 | A Novel Correction Equation Avoids High-Magnitude Errors in Interpreting Therapeutic Drug Monitoring of Phenytoin Among Critically Ill Patients. ( Barra, ME; Chung, DY; Phillips, KM; Rosenthal, ES, 2020) |
| "Phenytoin is a common medication for seizure treatment and prophylaxis in the intensive care unit (ICU)." | 1.43 | Correlation of Free and Total Phenytoin Serum Concentrations in Critically Ill Patients. ( Barletta, JF; Bikin, DS; Buckley, MS; Reeves, BA, 2016) |
| " A population pharmacokinetic approach was used to analyze paired protein-unbound and total phenytoin plasma concentrations (n = 146 each) from 32 critically ill children (0." | 1.42 | Population pharmacokinetics of phenytoin in critically ill children. ( Charles, B; Foster, K; Hennig, S; Lister, B; Norris, R; Riney, K; Tu, Q; van Breda, K, 2015) |
| " Future studies are needed to look at the dosing and monitoring of phenytoin and/or alternative anti-seizure prophylaxis in patients with traumatic brain injury." | 1.42 | Anti-seizure prophylaxis in critically ill patients with traumatic brain injury in an intensive care unit. ( Chapman, MJ; Edwards, S; Milne, D; Shakib, S; Sundararajan, K, 2015) |
| " A loading dose of intravenous phenytoin 2700 mg was administered, followed by maintenance dosing of intravenous phenytoin 150 mg every 8 hours." | 1.39 | Phenytoin removal by continuous venovenous hemofiltration. ( Herrmann, DJ; Oltrogge, KM; Peppard, WJ; Regner, KR; Saleh, M, 2013) |
| " Plasma concentrations of total phenytoin, unbound phenytoin, and the major metabolite of phenytoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin, were measured, and pharmacokinetic variables obtained before and after barbiturate therapy were compared." | 1.29 | Effect of barbiturate therapy on phenytoin pharmacokinetics. ( Abe, J; Asada, A; Fujimori, M; Kaji, A; Nishi, S; Oda, Y; Yoshida, N, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 13 (52.00) | 24.3611 |
| 2020's | 4 (16.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kalaria, SN | 1 |
| Armahizer, M | 1 |
| McCarthy, P | 1 |
| Badjatia, N | 1 |
| Gobburu, JV | 1 |
| Gopalakrishnan, M | 1 |
| Wiebe, AZ | 1 |
| Terry, K | 1 |
| Skaggs, J | 1 |
| Barra, ME | 1 |
| Phillips, KM | 1 |
| Chung, DY | 1 |
| Rosenthal, ES | 1 |
| Erstad, BL | 1 |
| Imai, T | 1 |
| Bolt, J | 1 |
| Gorman, SK | 1 |
| Kane, SP | 3 |
| Bress, AP | 2 |
| Tesoro, EP | 2 |
| Brown, AL | 1 |
| Sangha, KS | 1 |
| Mueller, EW | 1 |
| Kaur, D | 1 |
| Keegan, SP | 1 |
| Oltrogge, KM | 1 |
| Peppard, WJ | 1 |
| Saleh, M | 1 |
| Regner, KR | 1 |
| Herrmann, DJ | 1 |
| Hennig, S | 1 |
| Norris, R | 1 |
| Tu, Q | 1 |
| van Breda, K | 1 |
| Riney, K | 1 |
| Foster, K | 1 |
| Lister, B | 1 |
| Charles, B | 1 |
| Husain, AM | 1 |
| Sundararajan, K | 1 |
| Milne, D | 1 |
| Edwards, S | 1 |
| Chapman, MJ | 1 |
| Shakib, S | 1 |
| Buckley, MS | 2 |
| Reeves, BA | 1 |
| Barletta, JF | 2 |
| Bikin, DS | 2 |
| Kaufman, BA | 1 |
| Smetana, KS | 1 |
| Cook, AM | 1 |
| Bastin, ML | 1 |
| Oyler, DR | 1 |
| von Winckelmann, SL | 1 |
| Spriet, I | 1 |
| Willems, L | 1 |
| Wolf, GK | 1 |
| McClain, CD | 1 |
| Zurakowski, D | 1 |
| Dodson, B | 1 |
| McManus, ML | 1 |
| Zielmann, S | 1 |
| Mielck, F | 1 |
| Kahl, R | 1 |
| Kazmaier, S | 1 |
| Sydow, M | 1 |
| Kolk, J | 1 |
| Burchardi, H | 1 |
| Lindow, J | 1 |
| Wijdicks, EF | 1 |
| Yoshida, N | 1 |
| Oda, Y | 1 |
| Nishi, S | 1 |
| Abe, J | 1 |
| Kaji, A | 1 |
| Asada, A | 1 |
| Fujimori, M | 1 |
| Mlynarek, ME | 1 |
| Peterson, EL | 1 |
| Zarowitz, BJ | 1 |
| Williams, PJ | 1 |
| Roberts, WL | 1 |
| De, BK | 1 |
| Coleman, JP | 1 |
| Annesley, TM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Study of Pharmacokinetics of Levetiracetam in Patients Undergoing Intermittent Hemodialysis[NCT04511676] | 12 participants (Actual) | Observational | 2018-11-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for phenytoin and Critical Illness
| Article | Year |
|---|---|
Serum Albumin Levels: Who Needs Them?
Topics: Adult; Critical Illness; Humans; Hypoalbuminemia; Intensive Care Units; Phenytoin; Serum Albumin | 2021 |
[Evaluation of Pharmacotherapy on Emergency and Intensive Care Medicine: The Influence of Intensity and Duration of Invasion].
Topics: Critical Care; Critical Illness; Drug Monitoring; Drug Therapy; Emergency Medical Services; Humans; | 2017 |
Precision, bias, and clinical utility of the Sheiner-Tozer equation to guide phenytoin dosing in critically ill adults.
Topics: Adult; Algorithms; Anticonvulsants; Critical Illness; Dose-Response Relationship, Drug; Humans; Phen | 2013 |
Lacosamide in status epilepticus: Update on the TRENdS study.
Topics: Acetamides; Anticonvulsants; Critical Illness; Humans; Lacosamide; Phenytoin; Recurrence; Seizures; | 2015 |
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanec | 2016 |
Therapeutic drug monitoring of phenytoin in critically ill patients.
Topics: Animals; Anticonvulsants; Critical Illness; Drug Monitoring; Humans; Phenytoin | 2008 |
19 other studies available for phenytoin and Critical Illness
| Article | Year |
|---|---|
Development and Use of an Ex-Vivo In-Vivo Correlation to Predict Antiepileptic Drug Clearance in Patients Undergoing Continuous Renal Replacement Therapy.
Topics: Albumins; Anticonvulsants; Continuous Renal Replacement Therapy; Critical Illness; Drug Elimination | 2022 |
Phenytoin Serum Concentrations in Patients With Left Ventricular Support Devices: A Case Series.
Topics: Critical Illness; Extracorporeal Membrane Oxygenation; Heart-Assist Devices; Humans; Phenytoin; Retr | 2021 |
A Novel Correction Equation Avoids High-Magnitude Errors in Interpreting Therapeutic Drug Monitoring of Phenytoin Among Critically Ill Patients.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Critical Care; Critical Illness; Drug Monitoring; F | 2020 |
Characterization of unbound phenytoin concentrations in neurointensive care unit patients using a revised Winter-Tozer equation.
Topics: Adult; Age Factors; Aged; Algorithms; Anticonvulsants; Body Weight; Creatinine; Critical Illness; Hu | 2013 |
Response to "Characterization of unbound phenytoin concentrations in neurointensive care unit patients using a revised Winter-Tozer equation" by Sean P. Kane, Adam P. Bress, and Eljim P. Tesoro.
Topics: Algorithms; Anticonvulsants; Critical Illness; Humans; Intensive Care Units; Phenytoin | 2013 |
Phenytoin removal by continuous venovenous hemofiltration.
Topics: Acute Kidney Injury; Anticonvulsants; Critical Illness; Female; Hemofiltration; Humans; Liver Diseas | 2013 |
Author response to Brown et al characterization of free phenytoin concentrations in neurointensive care unit patients using a revised Winter-Tozer equation.
Topics: Algorithms; Anticonvulsants; Critical Illness; Humans; Intensive Care Units; Phenytoin | 2013 |
Population pharmacokinetics of phenytoin in critically ill children.
Topics: Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Critical Illness; Female; Hospita | 2015 |
Anti-seizure prophylaxis in critically ill patients with traumatic brain injury in an intensive care unit.
Topics: Adult; Aged; Anticonvulsants; Brain Injuries; Critical Illness; Female; Humans; Intensive Care Units | 2015 |
Correlation of Free and Total Phenytoin Serum Concentrations in Critically Ill Patients.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Critical Illness; Decision Making; Female; Humans; | 2016 |
Reply: Correlation of Free and Total Phenytoin Serum Concentrations in Critically Ill Patients.
Topics: Anticonvulsants; Critical Illness; Humans; Phenytoin; Protein Binding; Seizures | 2016 |
Comment: Correlation of Free and Total Phenytoin Serum Concentrations in Critically Ill Patients.
Topics: Anticonvulsants; Critical Illness; Humans; Phenytoin | 2016 |
Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Anticonvulsants; Blood Chemical Analysis; Cefazolin; Child | 2006 |
A rational basis for the measurement of free phenytoin concentration in critically ill trauma patients.
Topics: Adolescent; Adult; Aged; Craniocerebral Trauma; Critical Illness; Female; Humans; Kidney; Liver; Mal | 1994 |
Phenytoin toxicity associated with hypoalbuminemia in critically ill patients.
Topics: Adult; Aged; Aged, 80 and over; Critical Illness; Epilepsy, Tonic-Clonic; Female; Humans; Male; Midd | 1994 |
Effect of barbiturate therapy on phenytoin pharmacokinetics.
Topics: Adult; Aged; Aged, 80 and over; Critical Illness; Epilepsy; Female; Humans; Intracranial Pressure; M | 1993 |
Predicting unbound phenytoin concentrations in the critically ill neurosurgical patient.
Topics: Adult; Aged; Aged, 80 and over; Critical Illness; Female; Humans; Intensive Care Units; Male; Mathem | 1996 |
Comment: predicting unbound phenytoin concentrations in the critically ill neurosurgical patient.
Topics: Critical Illness; Humans; Neurosurgical Procedures; Phenytoin; Regression Analysis | 1996 |
Falsely increased immunoassay measurements of total and unbound phenytoin in critically ill uremic patients receiving fosphenytoin.
Topics: Acute Kidney Injury; Anticonvulsants; Chromatography, High Pressure Liquid; Critical Illness; Cross | 1999 |