phenytoin has been researched along with Craniocerebral Injuries in 49 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to determine potential negative neurobehavioral effects of phenytoin given to prevent the development of posttraumatic seizures, 244 subjects were randomized to phenytoin or placebo." | 9.07 | Neurobehavioral effects of phenytoin prophylaxis of posttraumatic seizures. ( Dikmen, SS; Machamer, J; Miller, B; Temkin, NR; Winn, HR, 1991) |
| "The causes of chronic, recurrent headaches, the electroencephalographic findings and the response to phenytoin (Dilantin) and other medications have been evaluated in 100 children." | 7.66 | Recurrent headaches in 100 children. Electroencephalographic abnormalities and response to phenytoin (Dilantin). ( Millichap, JG, 1978) |
| "Elderly nursing home patients (n = 46) taking chronic phenytoin therapy and patients enrolled in a double-blind, placebo-controlled study (n = 58) evaluating the use of phenytoin to prevent posttraumatic seizures." | 5.08 | Revised Winter-Tozer equation for normalized phenytoin concentrations in trauma and elderly patients with hypoalbuminemia. ( Anderson, GD; Doane, KW; Griffy, KG; Pak, C; Temkin, NR; Wilensky, AJ; Winn, HR, 1997) |
| "In order to determine potential negative neurobehavioral effects of phenytoin given to prevent the development of posttraumatic seizures, 244 subjects were randomized to phenytoin or placebo." | 5.07 | Neurobehavioral effects of phenytoin prophylaxis of posttraumatic seizures. ( Dikmen, SS; Machamer, J; Miller, B; Temkin, NR; Winn, HR, 1991) |
| " Antiepileptic drugs (AED) such as phenytoin are often used in clinical practice with the hopes of preventing post-traumatic epilepsy." | 4.91 | Pharmacological treatments for preventing epilepsy following traumatic head injury. ( Abel, H; Campbell, LA; Pohlmann-Eden, B; Thompson, K, 2015) |
| "In this systematic review we present information relating to the effectiveness and safety of the following interventions: antibiotics, anticonvulsants, corticosteroids, hyperventilation, hypothermia, and mannitol." | 4.84 | Head injury (moderate to severe). ( Maconochie, I; Ross, M, 2007) |
| " Tetanus prophylaxis and intravenous antibiotics were administered to all patients, and phenytoin was required in 16 (40%) cases." | 3.77 | Complicated head trauma from machete wounds: the experience from a tertiary referral hospital in Jamaica. ( Cawich, SO; Crandon, IW; Harding, HE; Webster, D, 2011) |
| "A 31-year-old woman who had a severe head injury was treated with oral phenytoin (100 mg 3 times a day) to prevent posttraumatic seizures." | 3.71 | Severe phenytoin intoxication in a subject homozygous for CYP2C9*3. ( Brandolese, R; Gusella, M; Padrini, R; Scordo, MG; Spina, E, 2001) |
| "Phenytoin is the most commonly administered antiepileptic agent for the prevention of early (< or = 7 days) posttraumatic seizures." | 3.71 | Pharmacist impact on posttraumatic seizure prophylaxis in patients with head injury. ( Brophy, GM; Garnett, WR; Schrote, GL; Tesoro, EP, 2002) |
| "Total (bound + unbound) and unbound phenytoin serum concentrations were measured in ten male comatose head trauma patients and ten male epileptic patients." | 3.66 | Importance of unbound phenytoin serum levels in head trauma patients. ( Bauer, LA; Brennan, C; Dellinger, EP; Edwards, WA; Raisys, VA, 1983) |
| "The causes of chronic, recurrent headaches, the electroencephalographic findings and the response to phenytoin (Dilantin) and other medications have been evaluated in 100 children." | 3.66 | Recurrent headaches in 100 children. Electroencephalographic abnormalities and response to phenytoin (Dilantin). ( Millichap, JG, 1978) |
| "Odds for epilepsy were higher among people who had positive family history (O." | 2.69 | A case control study and one year follow-up of registered epilepsy cases in a resettlement colony of North India, a developing tropical country. ( Chopra, JS; Kaur, P; Sawhney, IM; Singh, A; Suri, G, 1999) |
| " Drug levels were monitored throughout with appropriate dosage adjustment; however only 48% of the phenytoin group had plasma levels greater than 40 mumol/l." | 2.65 | Low risk of late post-traumatic seizures following severe head injury: implications for clinical trials of prophylaxis. ( Blackwood, DH; Harris, P; Johnson, AL; Kalbag, RM; McQueen, JK, 1983) |
| " Additional pharmacokinetic investigations are recommended to optimise pharmacological outcomes in patients with severe head injury." | 2.40 | Pharmacokinetic alterations after severe head injury. Clinical relevance. ( Boucher, BA; Hanes, SD, 1998) |
| "Gum hypertrophy is a well-known and important adverse effect of phenytoin therapy in a neurosurgical patient." | 1.42 | A well known and important adverse effect of phenytoin in a neurosurgical patient. ( Goyal, K; Kumar, N; Saxena, A; Tomar, GS, 2015) |
| "Assaults with a machete cause compound skull fractures which present as a neurosurgical emergency." | 1.40 | Cranial injuries secondary to assault with a machete. ( Enicker, B; Madiba, TE, 2014) |
| "Hyponatremia developed after head trauma in four patients and cerebral infarction in two patients." | 1.30 | Osmoregulation of vasopressin secretion in patients with the syndrome of inappropriate antidiuresis associated with central nervous system disorders. ( Kamoi, K; Koizumi, T; Muto, T; Niishiyama, K; Sasaki, H; Takagi, M; Takahashi, K; Toyama, M, 1999) |
| "Phenytoin is a medication administered for the treatment or prophylaxis of seizures in head-injured patients." | 1.29 | Case study of two methods for enteral phenytoin administration. ( Bader, MK, 1993) |
| "In the pediatric head trauma patient, a GCS score of 3 to 8 appears to be predictive of post-traumatic seizures." | 1.29 | Clinical predictors of post-traumatic seizures in children with head trauma. ( Gilmore, D; Inkelis, SH; Lewis, RJ; Yee, L, 1993) |
| "Treatment with phenytoin caused a dramatic clinical improvement." | 1.29 | Subclinical status epilepticus in a child after closed head injury. ( Beni, L; Constantini, S; Matoth, I; Pomeranz, S, 1996) |
| "Special treatment for hyponatremia was not given in 30 of the 58 cases (control group)." | 1.28 | [Mechanism and therapy of hyponatremia with central origin]. ( Morinaga, K; Ohkawara, S; Tabuse, H, 1989) |
| "A parenteral dosing regimen was designed for the immediate attainment and maintenance of therapeutic plasma levels of phenytoin in patients requiring anticonvulsant therapy, but not able to tolerate oral medication." | 1.26 | Maintenance of therapeutic phenytoin plasma levels via intramuscular administration. ( Cady, W; Hackman, J; Kostenbauder, H; Pancorbo, S; Perrier, D; Rapp, R; Young, B, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (42.86) | 18.7374 |
| 1990's | 18 (36.73) | 18.2507 |
| 2000's | 4 (8.16) | 29.6817 |
| 2010's | 6 (12.24) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Enicker, B | 1 |
| Madiba, TE | 1 |
| Thompson, K | 1 |
| Pohlmann-Eden, B | 1 |
| Campbell, LA | 1 |
| Abel, H | 1 |
| Tomar, GS | 1 |
| Saxena, A | 1 |
| Kumar, N | 1 |
| Goyal, K | 1 |
| Maconochie, I | 2 |
| Ross, M | 2 |
| Crandon, IW | 1 |
| Harding, HE | 1 |
| Cawich, SO | 1 |
| Webster, D | 1 |
| Atabey, C | 1 |
| Asir, A | 1 |
| Ersoy, T | 1 |
| Larney, V | 1 |
| Dwyer, R | 1 |
| McQueen, JK | 1 |
| Blackwood, DH | 1 |
| Harris, P | 1 |
| Kalbag, RM | 1 |
| Johnson, AL | 1 |
| Bauer, LA | 1 |
| Edwards, WA | 1 |
| Dellinger, EP | 1 |
| Raisys, VA | 1 |
| Brennan, C | 1 |
| O'Mara, NB | 1 |
| Jones, PR | 1 |
| Anglin, DL | 1 |
| Cox, S | 1 |
| Nahata, MC | 1 |
| Zielmann, S | 1 |
| Mielck, F | 1 |
| Kahl, R | 1 |
| Kazmaier, S | 1 |
| Sydow, M | 1 |
| Kolk, J | 1 |
| Burchardi, H | 1 |
| Bader, MK | 2 |
| Lewis, RJ | 1 |
| Yee, L | 1 |
| Inkelis, SH | 1 |
| Gilmore, D | 1 |
| Beni, L | 1 |
| Constantini, S | 1 |
| Matoth, I | 1 |
| Pomeranz, S | 1 |
| McKindley, DS | 1 |
| Boucher, BA | 2 |
| Hess, MM | 1 |
| Rodman, JH | 1 |
| Feler, C | 1 |
| Fabian, TC | 1 |
| Anderson, GD | 1 |
| Pak, C | 1 |
| Doane, KW | 1 |
| Griffy, KG | 1 |
| Temkin, NR | 2 |
| Wilensky, AJ | 1 |
| Winn, HR | 2 |
| Hanes, SD | 1 |
| Sawhney, IM | 1 |
| Singh, A | 1 |
| Kaur, P | 1 |
| Suri, G | 1 |
| Chopra, JS | 1 |
| Kamoi, K | 1 |
| Toyama, M | 1 |
| Takagi, M | 1 |
| Koizumi, T | 1 |
| Niishiyama, K | 1 |
| Takahashi, K | 1 |
| Sasaki, H | 1 |
| Muto, T | 1 |
| Lucke, JF | 1 |
| Brandolese, R | 1 |
| Scordo, MG | 1 |
| Spina, E | 1 |
| Gusella, M | 1 |
| Padrini, R | 1 |
| Brophy, GM | 1 |
| Tesoro, EP | 1 |
| Schrote, GL | 1 |
| Garnett, WR | 1 |
| Wohns, RN | 1 |
| Wyler, AR | 1 |
| Feldman, RG | 1 |
| Millichap, JG | 1 |
| Young, B | 2 |
| Rapp, RP | 1 |
| Perrier, D | 2 |
| Kostenbauder, H | 2 |
| Hackman, J | 2 |
| Blacker, HM | 1 |
| Caveness, WF | 1 |
| Rapp, R | 1 |
| Cady, W | 1 |
| Pancorbo, S | 1 |
| Mohan, KJ | 1 |
| Salo, MW | 1 |
| Nagaswami, S | 1 |
| Griebel, ML | 1 |
| Kearns, GL | 1 |
| Fiser, DH | 1 |
| Woody, RC | 1 |
| Turley, CP | 1 |
| Dikmen, SS | 1 |
| Miller, B | 1 |
| Machamer, J | 1 |
| Trimble, MR | 1 |
| Ziegler, MG | 1 |
| Morrissey, EC | 1 |
| Marshall, LF | 1 |
| Eldridge, PR | 1 |
| Punt, JA | 1 |
| Robbins, L | 1 |
| Morinaga, K | 1 |
| Tabuse, H | 1 |
| Ohkawara, S | 1 |
| Aitkenhead, A | 1 |
| Smith, JL | 1 |
| Sacks, E | 1 |
| Parkin, JL | 1 |
| Rapport, RL | 1 |
| Penry, JK | 1 |
| Alexander, E | 2 |
| Moss, G | 1 |
| Moss-Herjanic, B | 1 |
| Bouzarth, WF | 1 |
| Stowell, A | 1 |
5 reviews available for phenytoin and Craniocerebral Injuries
| Article | Year |
|---|---|
Pharmacological treatments for preventing epilepsy following traumatic head injury.
Topics: Adult; Anticonvulsants; Carbamazepine; Cause of Death; Child; Craniocerebral Trauma; Epilepsy; Human | 2015 |
Head injury (moderate to severe).
Topics: Acute Disease; Anticonvulsants; Brain Injuries; Craniocerebral Trauma; Glasgow Coma Scale; Humans; H | 2007 |
Head injury (moderate to severe).
Topics: Acute Disease; Anticonvulsants; Brain Injuries; Brain Ischemia; Coma; Craniocerebral Trauma; Glasgow | 2010 |
The role of antiseizure prophylaxis following head injury. Brain Trauma Foundation.
Topics: Anticonvulsants; Craniocerebral Trauma; Glasgow Coma Scale; Humans; MEDLINE; Phenytoin; Retrospectiv | 1996 |
Pharmacokinetic alterations after severe head injury. Clinical relevance.
Topics: Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Blood-Brain Barrier; Cranioce | 1998 |
5 trials available for phenytoin and Craniocerebral Injuries
| Article | Year |
|---|---|
Low risk of late post-traumatic seizures following severe head injury: implications for clinical trials of prophylaxis.
Topics: Adolescent; Adult; Aged; Brain Injuries; Child; Child, Preschool; Clinical Trials as Topic; Cranioce | 1983 |
Effect of acute phase response on phenytoin metabolism in neurotrauma patients.
Topics: Acute-Phase Reaction; Adolescent; Adult; Albumins; Anticonvulsants; Biological Availability; Cranioc | 1997 |
Revised Winter-Tozer equation for normalized phenytoin concentrations in trauma and elderly patients with hypoalbuminemia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Craniocerebral Trauma; Evaluation Studi | 1997 |
A case control study and one year follow-up of registered epilepsy cases in a resettlement colony of North India, a developing tropical country.
Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Child; Craniocerebral Trauma; Developmenta | 1999 |
Neurobehavioral effects of phenytoin prophylaxis of posttraumatic seizures.
Topics: Adult; Behavior; Cognition; Craniocerebral Trauma; Double-Blind Method; Female; Follow-Up Studies; H | 1991 |
39 other studies available for phenytoin and Craniocerebral Injuries
| Article | Year |
|---|---|
Cranial injuries secondary to assault with a machete.
Topics: Adolescent; Adult; Age Distribution; Anticonvulsants; Cerebrospinal Fluid Leak; Cerebrospinal Fluid | 2014 |
A well known and important adverse effect of phenytoin in a neurosurgical patient.
Topics: Accidents, Traffic; Anticonvulsants; Craniocerebral Trauma; Gingival Hypertrophy; Humans; Male; Phen | 2015 |
Complicated head trauma from machete wounds: the experience from a tertiary referral hospital in Jamaica.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Anticonvulsants; Cerebrospinal Fluid Leak; Cerebrosp | 2011 |
Management of head trauma due to landmine explosions: from battle field to operation room.
Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Blast Injuries; Cefazolin; Craniocerebral Trauma; For | 2012 |
Hyponatraemic convulsions and fatal head injury secondary to desmopressin treatment for enuresis.
Topics: Adult; Anticonvulsants; Antidiuretic Agents; Brain; Brain Edema; Craniocerebral Trauma; Craniotomy; | 2006 |
Importance of unbound phenytoin serum levels in head trauma patients.
Topics: Adult; Coma; Craniocerebral Trauma; Epilepsy, Post-Traumatic; Humans; Immunoenzyme Techniques; Male; | 1983 |
Pharmacokinetics of phenytoin in children with acute neurotrauma.
Topics: Acute Disease; Adolescent; Age Factors; Child; Child, Preschool; Craniocerebral Trauma; Drug Monitor | 1995 |
A rational basis for the measurement of free phenytoin concentration in critically ill trauma patients.
Topics: Adolescent; Adult; Aged; Craniocerebral Trauma; Critical Illness; Female; Humans; Kidney; Liver; Mal | 1994 |
Case study of two methods for enteral phenytoin administration.
Topics: Administration, Oral; Clinical Nursing Research; Clinical Protocols; Craniocerebral Trauma; Drug Mon | 1993 |
A case study of two methods of administering phenytoin enterally and the subsequent serum phenytoin levels in head-injured patients.
Topics: Administration, Oral; Clinical Nursing Research; Craniocerebral Trauma; Drug Monitoring; Enteral Nut | 1993 |
Clinical predictors of post-traumatic seizures in children with head trauma.
Topics: Adolescent; Child; Child, Preschool; Craniocerebral Trauma; Female; Glasgow Coma Scale; Head; Humans | 1993 |
Subclinical status epilepticus in a child after closed head injury.
Topics: Adolescent; Anticonvulsants; Craniocerebral Trauma; Electroencephalography; Female; Humans; Phenytoi | 1996 |
Osmoregulation of vasopressin secretion in patients with the syndrome of inappropriate antidiuresis associated with central nervous system disorders.
Topics: Aged; Arginine Vasopressin; Cerebral Infarction; Craniocerebral Trauma; Demeclocycline; Female; Foll | 1999 |
An introduction to the odds ratio.
Topics: Craniocerebral Trauma; Dose-Response Relationship, Drug; Enteral Nutrition; Gastrostomy; Humans; Odd | 1999 |
Severe phenytoin intoxication in a subject homozygous for CYP2C9*3.
Topics: Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Craniocerebral Trauma; Cytochrome P-450 CYP2C | 2001 |
Pharmacist impact on posttraumatic seizure prophylaxis in patients with head injury.
Topics: Adult; Anticonvulsants; Craniocerebral Trauma; Education, Pharmacy; Female; Humans; Male; Middle Age | 2002 |
Prophylactic phenytoin in severe head injuries.
Topics: Adult; Brain Injuries; Craniocerebral Trauma; Epilepsy, Post-Traumatic; Female; Humans; Male; Phenyt | 1979 |
Patients with epilepsy.
Topics: Affective Symptoms; Age Factors; Alcoholism; Barbiturates; Child; Child, Preschool; Craniocerebral T | 1975 |
Recurrent headaches in 100 children. Electroencephalographic abnormalities and response to phenytoin (Dilantin).
Topics: Adolescent; Child; Child, Preschool; Craniocerebral Trauma; Electroencephalography; Female; Headache | 1978 |
Early post-traumatic epilepsy prophylaxis.
Topics: Craniocerebral Trauma; Epilepsy, Post-Traumatic; Humans; Injections, Intramuscular; Phenytoin | 1975 |
Epilepsy, a product of trauma in our time.
Topics: Adolescent; Adult; Anticonvulsants; Brain Injuries; Craniocerebral Trauma; Environment; Epilepsy, Po | 1976 |
Maintenance of therapeutic phenytoin plasma levels via intramuscular administration.
Topics: Administration, Oral; Adolescent; Adult; Aged; Child; Child, Preschool; Craniocerebral Trauma; Drug | 1976 |
A case of limbic system dysfunction with hypersexualith and fugue state.
Topics: Adult; Brain Diseases; Craniocerebral Trauma; Dissociative Disorders; Female; Humans; Limbic System; | 1975 |
Phenytoin protein binding in pediatric patients with acute traumatic injury.
Topics: Acute Disease; Adolescent; Blood Urea Nitrogen; Child; Craniocerebral Trauma; Epilepsy, Post-Traumat | 1990 |
Neurobehavioral effects of anticonvulsants.
Topics: Anticonvulsants; Behavior; Cognition; Craniocerebral Trauma; Humans; Phenytoin; Seizures | 1991 |
Catecholamine and thyroid hormones in traumatic injury.
Topics: Adolescent; Adult; Brain Injuries; Burns; Catecholamines; Craniocerebral Trauma; Female; Humans; Mal | 1990 |
Risks associated with giving benzodiazepines to patients with acute neurological injuries.
Topics: Adult; Aged; Child; Craniocerebral Trauma; Diazepam; Emergency Medical Services; Female; Humans; Mal | 1990 |
Post-traumatic headache with scintillating scotoma treated with phenytoin (Dilantin).
Topics: Accidents, Traffic; Craniocerebral Trauma; Electroencephalography; Epilepsy, Post-Traumatic; Female; | 1989 |
[Mechanism and therapy of hyponatremia with central origin].
Topics: Aldosterone; Cerebrovascular Disorders; Craniocerebral Trauma; Glucose; Humans; Hydrocortisone; Hypo | 1989 |
Cerebral protection.
Topics: Adrenal Cortex Hormones; Barbiturates; Blood Glucose; Brain Edema; Brain Ischemia; Calcium Channel B | 1986 |
Epilepsy in a community--management and social impact.
Topics: Adolescent; Adult; Aged; Ambulatory Care Facilities; Carbamazepine; Craniocerebral Trauma; Epilepsy; | 1985 |
Tinnitus evaluation.
Topics: Bone Conduction; Brain Neoplasms; Cerebellopontine Angle; Craniocerebral Trauma; Diazepam; Ear Neopl | 1973 |
A survey of attitudes toward the pharmacological prophylaxis of posttraumatic epilepsy.
Topics: Anticonvulsants; Attitude of Health Personnel; Craniocerebral Trauma; Epilepsy, Post-Traumatic; Huma | 1973 |
Medical management of closed head injuries.
Topics: Adolescent; Adult; Aged; Airway Obstruction; Anti-Bacterial Agents; Blood Transfusion; Cerebral Angi | 1972 |
Surgical management of head injuries in children in the acute phase.
Topics: Adolescent; Age Factors; Cerebral Angiography; Child; Child, Preschool; Craniocerebral Trauma; Femal | 1972 |
The role of the central nervous system in shock: the centroneurogenic etiology of the respiratory distress syndrome.
Topics: Animals; Brain; Carbon Dioxide; Cardiac Output; Central Nervous System; Cerebrovascular Circulation; | 1974 |
Prolonged unconsciousness following electroconvulsive therapy.
Topics: Adult; Aged; Coma; Craniocerebral Trauma; Depression; Electroconvulsive Therapy; Epilepsies, Partial | 1967 |
The ABC's of emergency care of serious head injuries industry.
Topics: Cerebral Hemorrhage; Craniocerebral Trauma; First Aid; Neurologic Examination; Occupational Medicine | 1970 |
Physiologic mechanisms and treatment of histaminic or petrosal neuralgia.
Topics: Craniocerebral Trauma; Female; Headache; Histamine; Humans; Male; Meningoencephalitis; Methysergide; | 1970 |