phenytoin has been researched along with Conjugate Nystagmus in 71 studies
Excerpt | Relevance | Reference |
---|---|---|
"Two patients with intractable epilepsy who had been treated with various combinations of anticonvulsant drugs developed phenytoin encephalopathy." | 3.65 | Choreo-athetosis and encephalopathy induced by phenytoin. ( McLellan, DL; Swash, M, 1974) |
"Phenytoin is known to cause conduction slowing." | 1.39 | Fosphenytoin induced transient pendular nystagmus. ( Shaikh, AG, 2013) |
"Rhythmic horizontal nystagmus occurred in 7 patients, and only at extreme (40 degrees, 50 degrees) later gaze in 6 of these." | 1.26 | Conjugate lateral gaze nystagmus and free phenytoin concentrations in plasma: lack of correlation. ( Downes, H; Olsen, GD; Riker, WK; Smith, B, 1978) |
" The nystagmus disappeared when phenytoin dosage was reduced." | 1.26 | Downbeat nystagmus due to anticonvulsant toxicity. ( Alpert, JN, 1978) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 65 (91.55) | 18.7374 |
1990's | 3 (4.23) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 3 (4.23) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Shaikh, AG | 1 |
Praveen-kumar, S | 1 |
Desai, M | 1 |
Skinner, CG | 1 |
Chang, AS | 1 |
Matthews, AS | 1 |
Reedy, SJ | 1 |
Morgan, BW | 1 |
MEHRA, YN | 1 |
KUTT, H | 8 |
WINTERS, W | 3 |
KOKENGE, R | 2 |
MCDOWELL, F | 5 |
SCHERMAN, R | 1 |
KISHI, Y | 1 |
MANMARU, S | 1 |
FUKUI, S | 1 |
AOKI, Y | 1 |
Sutsui, J | 1 |
Watanabe, S | 1 |
Nobuto, F | 1 |
Harcourt, RB | 1 |
Frantzen, E | 1 |
Hansen, JM | 1 |
Hansen, OE | 1 |
Kristensen, M | 1 |
Berger, JR | 1 |
Kovacs, AG | 1 |
Mack, RB | 1 |
Esser, J | 1 |
Brandt, T | 1 |
Campbell, WW | 1 |
Herishanu, Y | 1 |
Osimani, A | 1 |
Louzoun, Z | 1 |
Wessely, P | 1 |
Mayr, N | 1 |
Binder, H | 1 |
Klingler, D | 1 |
Albertson, TE | 1 |
Fisher, CJ | 1 |
Shragg, TA | 1 |
Baselt, RC | 1 |
Vincent, FM | 1 |
Abe, K | 1 |
Okano, M | 1 |
Sasaki, H | 1 |
Kaplan, PW | 1 |
Tusa, RJ | 1 |
Katz, AA | 1 |
Hoffman, RS | 1 |
Silverman, RA | 1 |
Fleishaker, JC | 1 |
Pearson, LK | 1 |
Peters, GR | 1 |
Boldyrev, AI | 1 |
Fleĭs, EP | 1 |
Vaĭntrub, MIa | 1 |
Riker, WK | 1 |
Downes, H | 1 |
Olsen, GD | 1 |
Smith, B | 1 |
Beier, R | 1 |
Zschiesche, M | 1 |
Cammann, R | 1 |
Wolny, H | 1 |
Rościszewska, D | 1 |
Guz, I | 1 |
Krüger, H | 1 |
Alpert, JN | 1 |
Chadwick, D | 1 |
Reynolds, EH | 1 |
Marsden, CD | 1 |
Meran, A | 1 |
Pfaltz, CR | 1 |
Herberg, KP | 1 |
Livingston, S | 1 |
Berman, W | 1 |
Pauli, LL | 1 |
Howitt, KM | 1 |
Oziemski, MA | 1 |
Dehaene, I | 1 |
Van Vleymen, B | 1 |
Vessell, ES | 1 |
Passananti, GT | 1 |
Gauchel, FD | 1 |
Lehr, HJ | 1 |
Gauchel, G | 1 |
von Harnack, GA | 1 |
McLellan, DL | 1 |
Swash, M | 1 |
Green, JR | 1 |
Troupin, AS | 1 |
Halperm, LM | 1 |
Friel, P | 1 |
Kanarek, P | 1 |
Afifi, AK | 1 |
Van Allen, MW | 1 |
Lund, L | 1 |
Landy, PJ | 1 |
Sharpe, JA | 1 |
Murphy, MJ | 1 |
Goldstein, MN | 1 |
Geering, JM | 1 |
Ruch, W | 1 |
Dettli, L | 1 |
Shuttleworth, E | 1 |
Wise, G | 1 |
Paulson, G | 1 |
Riley, CG | 1 |
Booker, HE | 1 |
Darcey, B | 1 |
Lehtovaara, R | 1 |
Simpson, JF | 1 |
Gallagher, BB | 1 |
Baumel, IP | 1 |
Mattson, RH | 1 |
Woodbury, SG | 1 |
Juul-Jensen, P | 1 |
Schou, M | 1 |
Skrotskiĭ, IuA | 1 |
Vallarta, JM | 1 |
Bell, DB | 1 |
Reichert, A | 1 |
Kooiker, JC | 1 |
Sumi, SM | 1 |
Haerer, AF | 1 |
Grace, JB | 1 |
Ang, MK | 1 |
Guiang, R | 1 |
Berger, AR | 1 |
Holcomb, R | 1 |
Lynn, R | 1 |
Harvey, B | 1 |
Sweetman, BJ | 1 |
Gerber, N | 1 |
Davis, DG | 1 |
Smith, JL | 1 |
White, JC | 1 |
Coats, AC | 1 |
Behrman, S | 1 |
Brennan, RW | 1 |
Dehejia, H | 1 |
Verebely, K | 1 |
Iivanainen, M | 1 |
Viukari, M | 1 |
Kalensky, J | 1 |
Herzka, HS | 1 |
La Rosa, JC | 1 |
Brown, WV | 1 |
Frommer, PL | 1 |
Levy, RI | 1 |
McDowell, FH | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Prospective Randomized Study of Multidose Activated Charcoal in Supratherapeutic Phenytoin Serum Levels[NCT00823264] | 17 participants (Actual) | Interventional | 2008-08-31 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
We enrolled patients with elevated phenytoin levels into the study with greater than 30 ug/cc. The treatment arm received multiple doses of activated charcoal and the control arm received no activated charcoal. We obtained serum phenytoin levels every 6 hours for 24 hours then once every 24 hours. The time to reach a subtoxic level was determined in each arm by looking at serum phenytoin levels and documenting when it was below 25 ug/cc. (NCT00823264)
Timeframe: Serum phenytoin levels were obtained every 6 hours for 24 hours then once every 24 hours
Intervention | hours (Median) |
---|---|
Control | 41.1 |
Multiple Doses of Activated Charcoal | 19.3 |
3 reviews available for phenytoin and Conjugate Nystagmus
Article | Year |
---|---|
Biochemical and genetic factors regulating dilantin metabolism in man.
Topics: Aminosalicylic Acids; Animals; Ataxia; Cats; Chlordan; Cycloserine; DDT; Dicumarol; Disulfiram; Enzy | 1971 |
Utility of clinical chemical determinations of drug concentrations in biological fluids.
Topics: Adult; Allopurinol; Antipyrine; Ataxia; Chemistry, Clinical; Chromatography, Gas; Coffee; Desipramin | 1971 |
The use of blood levels of antiepileptic drugs in clinical practice.
Topics: Administration, Oral; Adult; Anticonvulsants; Biopharmaceutics; Carbamazepine; Child; Drug Tolerance | 1974 |
3 trials available for phenytoin and Conjugate Nystagmus
Article | Year |
---|---|
Randomized controlled study on the use of multiple-dose activated charcoal in patients with supratherapeutic phenytoin levels.
Topics: Adult; Aged; Anticonvulsants; Antidotes; Charcoal; Drug Overdose; Gait Ataxia; Hospitals, Teaching; | 2012 |
Induction of tirilazad clearance by phenytoin.
Topics: Adult; Anticonvulsants; Antioxidants; Ataxia; Cross-Over Studies; Dizziness; Dose-Response Relations | 1998 |
Sulthiame: evaluation as an anticonvulsant.
Topics: Anticonvulsants; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Evaluation; Electr | 1974 |
65 other studies available for phenytoin and Conjugate Nystagmus
Article | Year |
---|---|
Fosphenytoin induced transient pendular nystagmus.
Topics: Anticonvulsants; Brain; Epilepsy; Humans; Infusions, Intravenous; Magnetic Resonance Imaging; Male; | 2013 |
Ocular motor abnormalities in a patient with phenytoin toxicity--case report and minireview.
Topics: Anticonvulsants; Epilepsy, Tonic-Clonic; Humans; Male; Middle Aged; Nystagmus, Pathologic; Ocular Mo | 2014 |
EFFECTS OF ANTICONVULSIVE MEDICATION ON VESTIBULAR FUNCTION. AN ELECTRONYSTAGMOGRAPHIC STUDY.
Topics: Electronystagmography; Epilepsy; Humans; Nystagmus, Pathologic; Pharmacology; Phenobarbital; Phenyto | 1964 |
DIPHENYLHYDANTOIN METABOLISM, BLOOD LEVELS, AND TOXICITY.
Topics: Ataxia; Blood Chemical Analysis; Drug Tolerance; Humans; Mental Disorders; Metabolism; Nystagmus, Pa | 1964 |
DIPHENYLHYDANTOIN AND PHENOBARBITAL TOXICITY. THE ROLE OF LIVER DISEASE.
Topics: Ataxia; Barbiturates; Blood Chemical Analysis; Chromatography; Drug Tolerance; Hepatitis; Hepatitis | 1964 |
[TREATMENT OF EPILEPSY WITH 3-ETHOXYCARBO-5,5-DIPHENYLHYDANTOIN (P-6127), A NEW ANTICONVULSANT].
Topics: Anticonvulsants; Ataxia; Blood Chemical Analysis; Drug Therapy; Electroencephalography; Epilepsy; Ep | 1964 |
NEUROLOGICAL SEQUELAE FOLLOWING DILANTIN OVERDOSE IN A PATIENT AND IN EXPERIMENTAL ANIMALS.
Topics: Adolescent; Ataxia; Biomedical Research; Cats; Chlordiazepoxide; Drug Therapy; Epilepsy; Humans; Neu | 1965 |
[Treatment and etiological analysis of nystagmus amblyopia with neuro-psychotropic drugs].
Topics: Amblyopia; Amobarbital; Electroencephalography; Humans; Nystagmus, Pathologic; Phenytoin; Tranquiliz | 1966 |
Oral disorders associated with ocular disease. 3. Disorders affecting the alveoli and gums.
Topics: Alveolar Process; Blindness; Eye Diseases; Gingival Hyperplasia; Humans; Lacrimal Apparatus; Lead Po | 1967 |
Phenytoin (Dilantin) intoxication.
Topics: Adolescent; Adult; Aged; Anorexia Nervosa; Ataxia; Child; Epilepsy; Female; Humans; Male; Mental Dis | 1967 |
Downbeat nystagmus with phenytoin.
Topics: Adult; Ataxia; Central Nervous System Diseases; Female; Humans; Male; Middle Aged; Nystagmus, Pathol | 1982 |
Medical exorcism--acute dilantin intoxication.
Topics: Cardiovascular Diseases; Epilepsy; Humans; Kinetics; Nystagmus, Pathologic; Phenytoin | 1984 |
[Pharmacologically-caused eye movement disorders--differential diagnosis and mechanisms of action].
Topics: Alcoholism; Barbiturates; Cerebellar Diseases; Diagnosis, Differential; Eye Movements; Fixation, Ocu | 1983 |
Periodic alternating nystagmus in phenytoin intoxication.
Topics: Alcoholism; Cerebellar Ataxia; Epilepsy, Post-Traumatic; Humans; Male; Middle Aged; Nystagmus, Patho | 1980 |
Unidirectional gaze paretic nystagmus induced by phenytoin intoxication.
Topics: Adult; Electrooculography; Female; Humans; Nystagmus, Pathologic; Phenytoin | 1982 |
[Neurological signs in diphenylhydantoin intoxication (case reports and review) (author's transl)].
Topics: Adult; Biopsy; Cerebellar Ataxia; Electroencephalography; Epilepsy; Evoked Potentials; Female; Human | 1981 |
A prolonged severe intoxication after ingestion of phenytoin and phenobarbital.
Topics: Adult; Coma; Confusion; Female; Gastric Lavage; Humans; Nystagmus, Pathologic; Phenobarbital; Phenyt | 1981 |
Phenothiazine-induced phenytoin intoxication.
Topics: Adult; Aged; Ataxia; Drug Interactions; Dysarthria; Female; Humans; Male; Nystagmus, Pathologic; Phe | 1980 |
Phenytoin elimination kinetics in two children with drug intoxication.
Topics: Ataxia; Child; Female; Humans; Kinetics; Nystagmus, Pathologic; Phenytoin | 1980 |
Neurophysiologic and clinical correlations of epileptic nystagmus.
Topics: Adult; Aged; Child; Consciousness; Diazepam; Electroencephalography; Epilepsy; Eye Movements; Female | 1993 |
Phenytoin toxicity from smoking crack cocaine adulterated with phenytoin.
Topics: Adult; Ataxia; Charcoal; Crack Cocaine; Drug Contamination; Gastric Lavage; Humans; Male; Middle Age | 1993 |
[Neurologic complications following medical treatment of epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Ataxia; Benzodiazepines; Consciousness Disorders; Dysarthria; Ey | 1979 |
Conjugate lateral gaze nystagmus and free phenytoin concentrations in plasma: lack of correlation.
Topics: Adolescent; Adult; Aged; Electrooculography; Epilepsy; Female; Humans; Male; Middle Aged; Nystagmus, | 1978 |
[Phenytoin intoxication and serum level].
Topics: Adolescent; Adult; Aged; Ataxia; Athetosis; Attention; Child; Child, Preschool; Chorea; Dose-Respons | 1978 |
[Change of diphenylhydantoin tolerance at the time of reaching puberty in a 16-year-old girl suffering from epilepsy].
Topics: Adolescent; Drug Tolerance; Epilepsy; Female; Humans; Meniere Disease; Nystagmus, Pathologic; Phenyt | 1978 |
[Severe cerebellar lesions caused by diphenylhydantoin--a contribution to the problem of hydantoin poisoning].
Topics: Adolescent; Ataxia; Dietary Proteins; Dysarthria; Encephalitis; Epilepsy; Female; Humans; Nystagmus, | 1978 |
Downbeat nystagmus due to anticonvulsant toxicity.
Topics: Adult; Anticonvulsants; Carbamazepine; Eye Movements; Female; Humans; Nystagmus, Pathologic; Phenyto | 1978 |
Anticonvulsant-induced dyskinesias: a comparison with dyskinesias induced by neuroleptics.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cerebellar Diseases; Chorea; Dyskinesia, Dr | 1976 |
[The acute vestibular paralysis (author's transl)].
Topics: Adolescent; Adult; Aged; Amphetamines; Audiometry; Bacterial Infections; Cardiovascular Diseases; Ch | 1975 |
Delayed and insidious onset of diphenylhydantoin toxicity.
Topics: Adolescent; Adult; Animals; Cerebellar Ataxia; Drug Interactions; Electroencephalography; Epilepsy; | 1975 |
Anticonvulsant drug blood levels.
Topics: Anticonvulsants; Ataxia; Diplopia; Drug Therapy, Combination; Epilepsy; Humans; Nystagmus, Pathologi | 1975 |
Phenytoin toxicity induced by fluconazole.
Topics: Adult; Drug Interactions; Female; Fluconazole; Humans; Nystagmus, Pathologic; Phenytoin; Reflex, Abn | 1989 |
Opsoclonus induced by phenytoin and diazepam.
Topics: Diazepam; Drug Therapy, Combination; Eye Movements; Female; Humans; Middle Aged; Nystagmus, Patholog | 1987 |
[Diphenylhydantoin in children. Clinico-pharmacological studies].
Topics: Adolescent; Alkaline Phosphatase; Ataxia; Body Weight; Calcium; Child; Child, Preschool; Diplopia; D | 1973 |
Choreo-athetosis and encephalopathy induced by phenytoin.
Topics: Adolescent; Adult; Ataxia; Athetosis; Carbamazepine; Chorea; Diplopia; Electroencephalography; Epile | 1974 |
Cerebellar atrophy in epilepsy. Pneumographic and histological documentation of a case with psychosis.
Topics: Adult; Brain; Cerebellar Ataxia; Cerebral Ventriculography; Chlorpromazine; Diplopia; Electroconvuls | 1968 |
Anticonvulsant effect of diphenylhydantoin relative to plasma levels. A prospective three-year study in ambulant patients with generalized epileptic seizures.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Ataxia; Chromatography, Gas; Epilepsy; Epilepsy, Tonic-Clo | 1974 |
"Dilatin" overdosage.
Topics: Anticonvulsants; Ataxia; Brain Neoplasms; Carbamazepine; Diagnosis, Differential; Dibenzazepines; Ep | 1968 |
Diphenylhydantoin.
Topics: Affective Symptoms; Arrhythmias, Cardiac; Ataxia; Carbamazepine; Central Nervous System Diseases; Ch | 1971 |
Editoral: Rebound nystagmus--a cerebellar sign?
Topics: Brain Diseases; Brain Stem; Cerebellar Diseases; Cerebellar Neoplasms; Chronic Disease; Cranial Foss | 1974 |
Diphenylhydantoin-induced asterixis. A clinical study.
Topics: Ataxia; Electroencephalography; Electromyography; Epilepsy; Female; Humans; Male; Middle Aged; Nysta | 1974 |
[Diphenylhydantoin poisoning due to diphenylhydantoin-isoniazid interaction].
Topics: Adult; Cognition Disorders; Drug Interactions; Epilepsy; Fatigue; Humans; Isoniazid; Male; Middle Ag | 1974 |
Choreoathetosis and diphenylhydantoin intoxication.
Topics: Adolescent; Adult; Ataxia; Athetosis; Chorea; Diplopia; Female; Humans; Male; Nystagmus, Pathologic; | 1974 |
Chronic hydantoin intoxication: case report.
Topics: Adult; Cerebellar Ataxia; Cognition Disorders; Epilepsy; Female; Humans; Nystagmus, Pathologic; Phen | 1972 |
Serum concentrations of free diphenylhydantoin and their relationship to clinical intoxication.
Topics: Ataxia; Blood Proteins; Chromatography, Gas; Humans; Methods; Nystagmus, Pathologic; Phenytoin; Prot | 1973 |
Post-rotational nystagmus. An unreliable sign of diphenylhydantoin toxicity.
Topics: Chromatography, Thin Layer; Epilepsy; Humans; Nystagmus, Pathologic; Phenytoin; Rotation | 1973 |
Use of diphenylhydantoin.
Topics: Epilepsy; Humans; Injections, Intravenous; Nystagmus, Pathologic; Phenytoin | 1973 |
Primidone, diphenylhydantoin and phenobarbital. Aspects of acute and chronic toxicity.
Topics: Ataxia; Chromatography, Gas; Drug Tolerance; Epilepsy; Humans; Nystagmus, Pathologic; Phenobarbital; | 1973 |
Letter: Permanent brain damage after lithium intoxication.
Topics: Adult; Ataxia; Brain Damage, Chronic; Diuresis; Female; Humans; Lithium; Middle Aged; Nystagmus, Pat | 1973 |
[Complications of medical therapy for epilepsy in children and adolescents].
Topics: Anticonvulsants; Child; Diplopia; Drug Hypersensitivity; Drug Therapy, Combination; Epilepsy; Headac | 1973 |
Progressive encephalopathy due to chronic hydantoin intoxication.
Topics: Adolescent; Brain Diseases; Cerebellar Ataxia; Cerebellum; Child; Electroencephalography; Face; Fema | 1974 |
Movement disorder as a manifestation of diphenylhydantoin intoxication.
Topics: Adult; Ataxia; Athetosis; Chorea; Epilepsy; Female; Humans; Middle Aged; Nystagmus, Pathologic; Phen | 1974 |
Studies of anticonvulsant levels in epileptics. I. Serum diphenylhydantoin concentrations in a group of medically indigent outpatients.
Topics: Anticonvulsants; Barbiturates; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medical Indigency; Neurolog | 1969 |
Diphenylhydantoin (Dilantin) neurotoxicity--a deceptive syndrome.
Topics: Aged; Ataxia; Capsules; Diagnosis, Differential; Epilepsy, Tonic-Clonic; Humans; Male; Medication Er | 1969 |
Intoxication with 5,5-diphenylhydantoin (Dilantin): clinical features, blood levels, urinary metabolites, and metabolic changes in a child.
Topics: Ataxia; Child, Preschool; Glucuronates; Half-Life; Humans; Hyperglycemia; Insulin; Male; Movement Di | 1972 |
Periodic alternating nystagmus. A report of eight cases.
Topics: Adult; Aged; Albinism; Anemia, Aplastic; Anemia, Sickle Cell; Blindness; Demyelinating Diseases; Dia | 1971 |
Epileptic nystagmus.
Topics: Adult; Chlordiazepoxide; Electroencephalography; Epilepsy; Female; Humans; Neurologic Examination; N | 1971 |
Central electronystagmographic abnormalities.
Topics: Adult; Barbiturates; Brain Neoplasms; Brain Stem; Central Nervous System; Central Nervous System Dis | 1970 |
Delayed phenytoin idiosyncrasy.
Topics: Ataxia; Epilepsy; Humans; Nystagmus, Pathologic; Phenytoin | 1969 |
Diphenylhydantoin intoxication attendant to slow inactivation of isoniazid.
Topics: Animals; Ataxia; Cats; Drug Tolerance; Epilepsy; Genetics, Medical; Humans; Isoniazid; Nystagmus, Pa | 1970 |
[Phenytoin intoxication--an insidous complication in the treatment of epilepsy].
Topics: Adult; Body Weight; Cerebellar Diseases; Child; Epilepsy; Female; Humans; Male; Movement Disorders; | 1970 |
[Therapy of epilepsy in mentally retarded children. Neuropsychiatric disorders caused by diphenylhydantoin].
Topics: Adolescent; Affective Symptoms; Ataxia; Child; Epilepsy; Humans; Intellectual Disability; Male; Musc | 1970 |
Management of epilepsy with diphenylhydantoin sodium. Dosage regulation for problem patients.
Topics: Adult; Antitubercular Agents; Ataxia; Drug Tolerance; Epilepsy; Hospitalization; Humans; Nystagmus, | 1968 |
Clofibrate-induced ventricular arrhythmia.
Topics: Anticholesteremic Agents; Arrhythmias, Cardiac; Catecholamines; Cerebellar Ataxia; Creatine Kinase; | 1969 |
Depression of prahydroxylation of diphenylhydantoin by antituberculosis chemotherapy.
Topics: Adolescent; Adult; Aged; Aminosalicylic Acids; Anticonvulsants; Ataxia; Cycloserine; Drug Incompatib | 1966 |