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phenytoin and Coma

phenytoin has been researched along with Coma in 36 studies

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

ExcerptRelevanceReference
"We conducted a double-blind trial to determine whether a single intramuscular injection of fosphenytoin prevents seizures and neurologic sequelae in children with acute coma."9.17Fosphenytoin for seizure prevention in childhood coma in Africa: a randomized clinical trial. ( Chengo, EM; Crawley, J; Fegan, G; Gwer, SA; Idro, RI; Kihara, MN; Kirkham, FJ; Kivaya, E; Mpoya, A; Muchohi, SN; Newton, CR; Ogutu, BR, 2013)
"Valproic acid induced coma is presented in an adult patient without a history of metabolic disease."7.68Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. ( Colombo, JP; Straver, JS; van der Vijver, JC; van Woerkom, TC; Verbiest, HB, 1992)
"He also had visual hallucinations and temporary high blood pressure."5.37Pharmacoresistant convulsions and visual hallucinations around two weeks after selegiline overdose: a case report. ( Kato, S; Kobayashi, T; Saito, N; Shioda, K; Suda, S, 2011)
"Status epilepticus is one of the most frequent neurological emergencies in the intensive care unit."5.29Propofol in the management of refractory status epilepticus: a case report. ( Borgeat, A; Jallon, P; Suter, PM; Wilder-Smith, OH, 1994)
"We conducted a double-blind trial to determine whether a single intramuscular injection of fosphenytoin prevents seizures and neurologic sequelae in children with acute coma."5.17Fosphenytoin for seizure prevention in childhood coma in Africa: a randomized clinical trial. ( Chengo, EM; Crawley, J; Fegan, G; Gwer, SA; Idro, RI; Kihara, MN; Kirkham, FJ; Kivaya, E; Mpoya, A; Muchohi, SN; Newton, CR; Ogutu, BR, 2013)
"To report a case of hyperammonemia without hepatic dysfunction as a possible cause of lethargy, stupor, and coma in a woman after valproic acid (VPA) administration, and discuss the possible different mechanisms of ammonia elevation and coma."4.78Valproate-induced coma: case report and literature review. ( Clavería, LE; Coria, F; Duarte, J; Fernandez, E; Macias, S, 1993)
"Valproic acid induced coma is presented in an adult patient without a history of metabolic disease."3.68Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. ( Colombo, JP; Straver, JS; van der Vijver, JC; van Woerkom, TC; Verbiest, HB, 1992)
"Total (bound + unbound) and unbound phenytoin serum concentrations were measured in ten male comatose head trauma patients and ten male epileptic patients."3.66Importance of unbound phenytoin serum levels in head trauma patients. ( Bauer, LA; Brennan, C; Dellinger, EP; Edwards, WA; Raisys, VA, 1983)
"Total external ophthalmoplegia was observed in five patients consequent to the oral or intravenous administration of phenytoin."3.65Phenytoin-induced ophthalmoplegia. ( Davidoff, RA; Schwartzman, RJ; Spector, RH, 1976)
"ECTR is suggested if prolonged coma is present or expected (graded 2D) and it would be reasonable if prolonged incapacitating ataxia is present or expected (graded 3D)."2.53Extracorporeal Treatment in Phenytoin Poisoning: Systematic Review and Recommendations from the EXTRIP (Extracorporeal Treatments in Poisoning) Workgroup. ( Anseeuw, K; Burdmann, EA; Ghannoum, M; Gosselin, S; Hoffman, RS; Lavergne, V; Mowry, JB; Nolin, TD, 2016)
"Seizures are commonly encountered in patients who do not have epilepsy."2.40Medical causes of seizures. ( Delanty, N; French, JA; Vaughan, CJ, 1998)
"He also had visual hallucinations and temporary high blood pressure."1.37Pharmacoresistant convulsions and visual hallucinations around two weeks after selegiline overdose: a case report. ( Kato, S; Kobayashi, T; Saito, N; Shioda, K; Suda, S, 2011)
"A 75-year-old man suffered a cardiac arrest and severe anoxic encephalopathy."1.30Periodic complexes, absence-like status and suppression-burst pattern in coma following cardiorespiratory arrest. ( Chemmale, J; Devrajan, VN; Ganji, SS; McDonald, L; Palliyath, S, 1997)
"Status epilepticus is one of the most frequent neurological emergencies in the intensive care unit."1.29Propofol in the management of refractory status epilepticus: a case report. ( Borgeat, A; Jallon, P; Suter, PM; Wilder-Smith, OH, 1994)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199024 (66.67)18.7374
1990's5 (13.89)18.2507
2000's0 (0.00)29.6817
2010's7 (19.44)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gwer, SA1
Idro, RI1
Fegan, G1
Chengo, EM1
Mpoya, A1
Kivaya, E1
Crawley, J1
Muchohi, SN1
Kihara, MN1
Ogutu, BR1
Kirkham, FJ1
Newton, CR1
Anseeuw, K1
Mowry, JB1
Burdmann, EA1
Ghannoum, M1
Hoffman, RS1
Gosselin, S1
Lavergne, V1
Nolin, TD1
Nelsen, JL1
Lapoint, J1
Hodgman, MJ1
Aldous, KM1
Suresh Chandran, CJ1
Saddiq, MH1
Joji, P1
Unni, M1
Maconochie, I1
Ross, M1
Bischoff, K1
Jaeger, R1
Ebel, JG1
Kobayashi, T1
Saito, N1
Suda, S1
Shioda, K1
Kato, S1
FROMMEL, E1
RADOUCO-THOMAS, C1
CELESIA, GG1
ANDERMANN, F1
LIEBERMAN, A1
RIZZUTO, VJ1
INGLESBY, TV1
GRACE, WJ1
Perez del Cerro, M1
Snider, RS1
Levy, RS1
Jankovic, J1
Sabato, AF1
Pala, F1
Sammartino, M1
Barbi, S1
Beccia, F1
Lüscher, TF1
Siegenthaler-Zuber, G1
Kuhlmann, U1
Bauer, LA1
Edwards, WA1
Dellinger, EP1
Raisys, VA1
Brennan, C1
Albertson, TE1
Fisher, CJ1
Shragg, TA1
Baselt, RC1
Borgeat, A1
Wilder-Smith, OH1
Jallon, P1
Suter, PM1
Duarte, J1
Macias, S1
Coria, F1
Fernandez, E1
Clavería, LE1
Ganji, SS1
Palliyath, S1
Chemmale, J1
Devrajan, VN1
McDonald, L1
Delanty, N1
Vaughan, CJ1
French, JA1
Besser, R1
Schuster, CJ1
Spector, RH1
Davidoff, RA1
Schwartzman, RJ1
Verbiest, HB1
Straver, JS1
Colombo, JP1
van der Vijver, JC1
van Woerkom, TC1
Fahn, S1
Goto, K1
Suekawa, M1
Aburada, M1
Hosoya, E1
Aitkenhead, A1
Lehtovaara, R1
Karch, SB1
Moss-Herjanic, B1
Madden, JS1
Jones, D1
Frisch, EP1
Viukari, NM1
Aho, K1
Riddell, D1
Leonard, BE1
Sampson, D1
Harasymiv, I1
Hensley, WJ1
Tenckhoff, H1
Sherrard, DJ1
Hickman, RO1
Ladda, RL1
Goldberg, EM1
Sanbar, SS1

Reviews

5 reviews available for phenytoin and Coma

ArticleYear
Extracorporeal Treatment in Phenytoin Poisoning: Systematic Review and Recommendations from the EXTRIP (Extracorporeal Treatments in Poisoning) Workgroup.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2016, Volume: 67, Issue:2

    Topics: Coma; Education; Humans; Phenytoin; Practice Guidelines as Topic; Renal Dialysis; Treatment Outcome

2016
Head injury (moderate to severe).
    BMJ clinical evidence, 2010, Jun-10, Volume: 2010

    Topics: Acute Disease; Anticonvulsants; Brain Injuries; Brain Ischemia; Coma; Craniocerebral Trauma; Glasgow

2010
Valproate-induced coma: case report and literature review.
    The Annals of pharmacotherapy, 1993, Volume: 27, Issue:5

    Topics: Ammonia; Coma; Epilepsy, Complex Partial; Female; Humans; Middle Aged; Phenobarbital; Phenytoin; Val

1993
Medical causes of seizures.
    Lancet (London, England), 1998, Aug-01, Volume: 352, Issue:9125

    Topics: Acute Kidney Injury; Anticonvulsants; Antitubercular Agents; Blood Pressure; Brain Diseases; Broncho

1998
Posthypoxic action myoclonus: literature review update.
    Advances in neurology, 1986, Volume: 43

    Topics: Adult; Clonazepam; Coma; Electroencephalography; Female; Functional Laterality; Heart Arrest; Humans

1986

Trials

1 trial available for phenytoin and Coma

ArticleYear
Fosphenytoin for seizure prevention in childhood coma in Africa: a randomized clinical trial.
    Journal of critical care, 2013, Volume: 28, Issue:6

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Coma; Double-Blind Method; Electroencephalogra

2013

Other Studies

30 other studies available for phenytoin and Coma

ArticleYear
Seizure and coma following Kratom (Mitragynina speciosa Korth) exposure.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2010, Volume: 6, Issue:4

    Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Coma; Glasgow Coma Scale; Humans; Intubation,

2010
Hemi brain demyelination--a variant of acute disseminated encephalomyelitis.
    Indian journal of medical sciences, 2010, Volume: 64, Issue:12

    Topics: Acyclovir; Anti-Inflammatory Agents; Anticonvulsants; Antiviral Agents; Brain; Child; Coma; Encephal

2010
An unusual case of relay pentobarbital toxicosis in a dog.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2011, Volume: 7, Issue:3

    Topics: Adipose Tissue; Animals; Anticonvulsants; Coma; Dog Diseases; Dogs; Female; Gas Chromatography-Mass

2011
Pharmacoresistant convulsions and visual hallucinations around two weeks after selegiline overdose: a case report.
    Pharmacopsychiatry, 2011, Volume: 44, Issue:7

    Topics: Anticonvulsants; Bipolar Disorder; Coma; Diazepam; Drug Overdose; Drug Resistance; Hallucinations; H

2011
[Effects of phenobarbital, acylureas and diphenylhydantoin on coma during electric epileptic crisis in guinea pig. II..].
    Helvetica physiologica et pharmacologica acta, 1953, Volume: 11, Issue:3

    Topics: Anticonvulsants; Barbiturates; Coma; Electricity; Epilepsy; Guinea Pigs; Phenobarbital; Phenytoin; S

1953
SOME OBSERVATIONS ON THE ELECTROGRAPHIC CORRELATES OF THE DECEREBRATE ATTACK.
    Electroencephalography and clinical neurophysiology, 1964, Volume: 16

    Topics: Child; Coma; Decerebrate State; Electroencephalography; Epilepsy; Humans; Hypoxia, Brain; Infusions,

1964
INTERMITTENT CEREBRAL INSUFFICIENCY. REPORT OF CASE WITH COMPLETE CLINICAL RECOVERY BETWEEN EPISODES OF COMA.
    Geriatrics, 1965, Volume: 20

    Topics: Arteriosclerosis; Autonomic Nerve Block; Carotid Artery Thrombosis; Cerebral Angiography; Cerebral I

1965
PROBENECID (BENEMID) INTOXICATION WITH STATUS EPILEPTICUS.
    The American journal of medicine, 1965, Volume: 38

    Topics: Coma; Drug Therapy; Epilepsy; Gout; Phenobarbital; Phenytoin; Poisoning; Probenecid; Status Epilepti

1965
Studies on Dilantin intoxication. I. Ultrastructural analogies with the lipoidoses.
    Neurology, 1967, Volume: 17, Issue:5

    Topics: Animals; Ataxia; Cerebellar Cortex; Coma; Cytoplasmic Granules; Lipidoses; Male; Microscopy, Electro

1967
Placebo-induced conversion reaction: a neurobehavioral and EEG study of hysterical aphasia, seizure, and coma.
    Journal of abnormal psychology, 1983, Volume: 92, Issue:2

    Topics: Adult; Aphasia; Coma; Conversion Disorder; Female; Humans; Phenytoin; Seizures; Set, Psychology

1983
The brain amino acid pattern in experimental coma due to phenytoin in guinea pigs.
    Resuscitation, 1984, Volume: 11, Issue:1-2

    Topics: Amino Acids; Animals; Brain; Chromatography, Ion Exchange; Coma; Guinea Pigs; Phenytoin

1984
Severe hypernatremic coma due to diphenylhydantoin intoxication.
    Clinical nephrology, 1983, Volume: 20, Issue:5

    Topics: Adult; Coma; Epilepsy, Tonic-Clonic; Female; Humans; Hypernatremia; Phenytoin

1983
Importance of unbound phenytoin serum levels in head trauma patients.
    The Journal of trauma, 1983, Volume: 23, Issue:12

    Topics: Adult; Coma; Craniocerebral Trauma; Epilepsy, Post-Traumatic; Humans; Immunoenzyme Techniques; Male;

1983
A prolonged severe intoxication after ingestion of phenytoin and phenobarbital.
    The Western journal of medicine, 1981, Volume: 135, Issue:5

    Topics: Adult; Coma; Confusion; Female; Gastric Lavage; Humans; Nystagmus, Pathologic; Phenobarbital; Phenyt

1981
Propofol in the management of refractory status epilepticus: a case report.
    Intensive care medicine, 1994, Volume: 20, Issue:2

    Topics: Clonazepam; Coma; Drug Therapy, Combination; Electroencephalography; Glasgow Coma Scale; Humans; Inf

1994
Periodic complexes, absence-like status and suppression-burst pattern in coma following cardiorespiratory arrest.
    Clinical EEG (electroencephalography), 1997, Volume: 28, Issue:2

    Topics: Aged; Anticonvulsants; Brain; Coma; Diazepam; Electroencephalography; Epilepsy, Absence; Heart Arres

1997
[Influence of diphenylhydantoine on delta sharp-waves in coma. A clinical contribution (author's transl)].
    EEG-EMG Zeitschrift fur Elektroenzephalographie, Elektromyographie und verwandte Gebiete, 1979, Volume: 10, Issue:3

    Topics: Coma; Delta Rhythm; Humans; Male; Middle Aged; Narcotics; Phenytoin; Poisoning

1979
Phenytoin-induced ophthalmoplegia.
    Neurology, 1976, Volume: 26, Issue:11

    Topics: Adolescent; Adult; Coma; Epilepsy, Tonic-Clonic; Humans; Male; Middle Aged; Ophthalmoplegia; Phenyto

1976
Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.
    Acta neurologica Scandinavica, 1992, Volume: 86, Issue:3

    Topics: Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Atrophy; Carbamoyl-Phosphate Synthase (Ammonia

1992
[Pharmacological study of TJ-8007 (Tsumura-Zokumeito) (I): Protective effects of TJ-8007 against anoxic brain damage].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1987, Volume: 89, Issue:6

    Topics: Animals; Brain Damage, Chronic; Coma; Drugs, Chinese Herbal; Hypoxia, Brain; Male; Medicine, Chinese

1987
Cerebral protection.
    British journal of hospital medicine, 1986, Volume: 35, Issue:5

    Topics: Adrenal Cortex Hormones; Barbiturates; Blood Glucose; Brain Edema; Brain Ischemia; Calcium Channel B

1986
[Therapy in traumatic epilepsy].
    Duodecim; laaketieteellinen aikakauskirja, 1971, Volume: 87, Issue:16

    Topics: Adult; Barbiturates; Bromides; Carbamazepine; Coma; Disabled Persons; Drug Resistance; Epilepsy, Pos

1971
Methsuximide overdose. Delayed onset of profound coma.
    JAMA, 1973, Mar-26, Volume: 223, Issue:13

    Topics: Administration, Oral; Adolescent; Anticonvulsants; Central Nervous System; Coma; Drug Synergism; Ele

1973
Prolonged unconsciousness following electroconvulsive therapy.
    The American journal of psychiatry, 1967, Volume: 124, Issue:1

    Topics: Adult; Aged; Coma; Craniocerebral Trauma; Depression; Electroconvulsive Therapy; Epilepsies, Partial

1967
Chlormethiazole and trifluoperazine in alcohol withdrawal.
    The British journal of psychiatry : the journal of mental science, 1969, Volume: 115, Issue:527

    Topics: Alcoholism; Chlormethiazole; Coma; Depression; Feeding and Eating Disorders; Female; Headache; Human

1969
Digoxin-phenytoin interaction.
    British medical journal, 1970, Apr-04, Volume: 2, Issue:5700

    Topics: Ataxia; Cerebellar Diseases; Coma; Digoxin; Humans; Male; Middle Aged; Phenytoin

1970
Some properties of a coma producing material obtained from mammalian brain.
    Neuropharmacology, 1970, Volume: 9, Issue:3

    Topics: Amylases; Animals; Blood Pressure; Brain Chemistry; Carbamazepine; Cats; Cerebral Cortex; Chromatogr

1970
Gas chromatographic assay of underivatized 5,5-diphenylhydantoin (dilantin) in plasma extracts.
    Clinical chemistry, 1971, Volume: 17, Issue:5

    Topics: Carbamazepine; Chloroform; Chromatography, Gas; Coma; Epilepsy; Humans; Hydrogen-Ion Concentration;

1971
Acute diphenylhydantoin intoxication.
    American journal of diseases of children (1960), 1968, Volume: 116, Issue:4

    Topics: Child, Preschool; Coma; Decerebrate State; Humans; Male; Peritoneal Dialysis; Phenytoin

1968
Hyperglycemic, nonketotic coma following administration of Dilantin (Diphenylhydantoin).
    Diabetes, 1969, Volume: 18, Issue:2

    Topics: Animals; Blood Glucose; Blood Pressure; Coma; Dogs; Fatty Acids, Nonesterified; Humans; Hyperglycemi

1969