Page last updated: 2024-10-21

phenytoin and Coma

phenytoin has been researched along with Coma in 36 studies

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

Excerpt	Relevance	Reference
"We conducted a double-blind trial to determine whether a single intramuscular injection of fosphenytoin prevents seizures and neurologic sequelae in children with acute coma."	9.17	Fosphenytoin for seizure prevention in childhood coma in Africa: a randomized clinical trial. ( Chengo, EM; Crawley, J; Fegan, G; Gwer, SA; Idro, RI; Kihara, MN; Kirkham, FJ; Kivaya, E; Mpoya, A; Muchohi, SN; Newton, CR; Ogutu, BR, 2013)
"Valproic acid induced coma is presented in an adult patient without a history of metabolic disease."	7.68	Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. ( Colombo, JP; Straver, JS; van der Vijver, JC; van Woerkom, TC; Verbiest, HB, 1992)
"He also had visual hallucinations and temporary high blood pressure."	5.37	Pharmacoresistant convulsions and visual hallucinations around two weeks after selegiline overdose: a case report. ( Kato, S; Kobayashi, T; Saito, N; Shioda, K; Suda, S, 2011)
"Status epilepticus is one of the most frequent neurological emergencies in the intensive care unit."	5.29	Propofol in the management of refractory status epilepticus: a case report. ( Borgeat, A; Jallon, P; Suter, PM; Wilder-Smith, OH, 1994)
"We conducted a double-blind trial to determine whether a single intramuscular injection of fosphenytoin prevents seizures and neurologic sequelae in children with acute coma."	5.17	Fosphenytoin for seizure prevention in childhood coma in Africa: a randomized clinical trial. ( Chengo, EM; Crawley, J; Fegan, G; Gwer, SA; Idro, RI; Kihara, MN; Kirkham, FJ; Kivaya, E; Mpoya, A; Muchohi, SN; Newton, CR; Ogutu, BR, 2013)
"To report a case of hyperammonemia without hepatic dysfunction as a possible cause of lethargy, stupor, and coma in a woman after valproic acid (VPA) administration, and discuss the possible different mechanisms of ammonia elevation and coma."	4.78	Valproate-induced coma: case report and literature review. ( Clavería, LE; Coria, F; Duarte, J; Fernandez, E; Macias, S, 1993)
"Valproic acid induced coma is presented in an adult patient without a history of metabolic disease."	3.68	Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. ( Colombo, JP; Straver, JS; van der Vijver, JC; van Woerkom, TC; Verbiest, HB, 1992)
"Total (bound + unbound) and unbound phenytoin serum concentrations were measured in ten male comatose head trauma patients and ten male epileptic patients."	3.66	Importance of unbound phenytoin serum levels in head trauma patients. ( Bauer, LA; Brennan, C; Dellinger, EP; Edwards, WA; Raisys, VA, 1983)
"Total external ophthalmoplegia was observed in five patients consequent to the oral or intravenous administration of phenytoin."	3.65	Phenytoin-induced ophthalmoplegia. ( Davidoff, RA; Schwartzman, RJ; Spector, RH, 1976)
"ECTR is suggested if prolonged coma is present or expected (graded 2D) and it would be reasonable if prolonged incapacitating ataxia is present or expected (graded 3D)."	2.53	Extracorporeal Treatment in Phenytoin Poisoning: Systematic Review and Recommendations from the EXTRIP (Extracorporeal Treatments in Poisoning) Workgroup. ( Anseeuw, K; Burdmann, EA; Ghannoum, M; Gosselin, S; Hoffman, RS; Lavergne, V; Mowry, JB; Nolin, TD, 2016)
"Seizures are commonly encountered in patients who do not have epilepsy."	2.40	Medical causes of seizures. ( Delanty, N; French, JA; Vaughan, CJ, 1998)
"He also had visual hallucinations and temporary high blood pressure."	1.37	Pharmacoresistant convulsions and visual hallucinations around two weeks after selegiline overdose: a case report. ( Kato, S; Kobayashi, T; Saito, N; Shioda, K; Suda, S, 2011)
"A 75-year-old man suffered a cardiac arrest and severe anoxic encephalopathy."	1.30	Periodic complexes, absence-like status and suppression-burst pattern in coma following cardiorespiratory arrest. ( Chemmale, J; Devrajan, VN; Ganji, SS; McDonald, L; Palliyath, S, 1997)
"Status epilepticus is one of the most frequent neurological emergencies in the intensive care unit."	1.29	Propofol in the management of refractory status epilepticus: a case report. ( Borgeat, A; Jallon, P; Suter, PM; Wilder-Smith, OH, 1994)

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	24 (66.67)	18.7374
1990's	5 (13.89)	18.2507
2000's	0 (0.00)	29.6817
2010's	7 (19.44)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Gwer, SA	1
Idro, RI	1
Fegan, G	1
Chengo, EM	1
Mpoya, A	1
Kivaya, E	1
Crawley, J	1
Muchohi, SN	1
Kihara, MN	1
Ogutu, BR	1
Kirkham, FJ	1
Newton, CR	1
Anseeuw, K	1
Mowry, JB	1
Burdmann, EA	1
Ghannoum, M	1
Hoffman, RS	1
Gosselin, S	1
Lavergne, V	1
Nolin, TD	1
Nelsen, JL	1
Lapoint, J	1
Hodgman, MJ	1
Aldous, KM	1
Suresh Chandran, CJ	1
Saddiq, MH	1
Joji, P	1
Unni, M	1
Maconochie, I	1
Ross, M	1
Bischoff, K	1
Jaeger, R	1
Ebel, JG	1
Kobayashi, T	1
Saito, N	1
Suda, S	1
Shioda, K	1
Kato, S	1
FROMMEL, E	1
RADOUCO-THOMAS, C	1
CELESIA, GG	1
ANDERMANN, F	1
LIEBERMAN, A	1
RIZZUTO, VJ	1
INGLESBY, TV	1
GRACE, WJ	1
Perez del Cerro, M	1
Snider, RS	1
Levy, RS	1
Jankovic, J	1
Sabato, AF	1
Pala, F	1
Sammartino, M	1
Barbi, S	1
Beccia, F	1
Lüscher, TF	1
Siegenthaler-Zuber, G	1
Kuhlmann, U	1
Bauer, LA	1
Edwards, WA	1
Dellinger, EP	1
Raisys, VA	1
Brennan, C	1
Albertson, TE	1
Fisher, CJ	1
Shragg, TA	1
Baselt, RC	1
Borgeat, A	1
Wilder-Smith, OH	1
Jallon, P	1
Suter, PM	1
Duarte, J	1
Macias, S	1
Coria, F	1
Fernandez, E	1
Clavería, LE	1
Ganji, SS	1
Palliyath, S	1
Chemmale, J	1
Devrajan, VN	1
McDonald, L	1
Delanty, N	1
Vaughan, CJ	1
French, JA	1
Besser, R	1
Schuster, CJ	1
Spector, RH	1
Davidoff, RA	1
Schwartzman, RJ	1
Verbiest, HB	1
Straver, JS	1
Colombo, JP	1
van der Vijver, JC	1
van Woerkom, TC	1
Fahn, S	1
Goto, K	1
Suekawa, M	1
Aburada, M	1
Hosoya, E	1
Aitkenhead, A	1
Lehtovaara, R	1
Karch, SB	1
Moss-Herjanic, B	1
Madden, JS	1
Jones, D	1
Frisch, EP	1
Viukari, NM	1
Aho, K	1
Riddell, D	1
Leonard, BE	1
Sampson, D	1
Harasymiv, I	1
Hensley, WJ	1
Tenckhoff, H	1
Sherrard, DJ	1
Hickman, RO	1
Ladda, RL	1
Goldberg, EM	1
Sanbar, SS	1

Reviews

5 reviews available for phenytoin and Coma

Article	Year
Extracorporeal Treatment in Phenytoin Poisoning: Systematic Review and Recommendations from the EXTRIP (Extracorporeal Treatments in Poisoning) Workgroup. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2016, Volume: 67, Issue:2 Topics: Coma; Education; Humans; Phenytoin; Practice Guidelines as Topic; Renal Dialysis; Treatment Outcome	2016
Head injury (moderate to severe). BMJ clinical evidence, 2010, Jun-10, Volume: 2010 Topics: Acute Disease; Anticonvulsants; Brain Injuries; Brain Ischemia; Coma; Craniocerebral Trauma; Glasgow	2010
Valproate-induced coma: case report and literature review. The Annals of pharmacotherapy, 1993, Volume: 27, Issue:5 Topics: Ammonia; Coma; Epilepsy, Complex Partial; Female; Humans; Middle Aged; Phenobarbital; Phenytoin; Val	1993
Medical causes of seizures. Lancet (London, England), 1998, Aug-01, Volume: 352, Issue:9125 Topics: Acute Kidney Injury; Anticonvulsants; Antitubercular Agents; Blood Pressure; Brain Diseases; Broncho	1998
Posthypoxic action myoclonus: literature review update. Advances in neurology, 1986, Volume: 43 Topics: Adult; Clonazepam; Coma; Electroencephalography; Female; Functional Laterality; Heart Arrest; Humans	1986

Trials

1 trial available for phenytoin and Coma

Article	Year
Fosphenytoin for seizure prevention in childhood coma in Africa: a randomized clinical trial. Journal of critical care, 2013, Volume: 28, Issue:6 Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Coma; Double-Blind Method; Electroencephalogra	2013

Other Studies

30 other studies available for phenytoin and Coma

Article	Year
Seizure and coma following Kratom (Mitragynina speciosa Korth) exposure. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2010, Volume: 6, Issue:4 Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Coma; Glasgow Coma Scale; Humans; Intubation,	2010
Hemi brain demyelination--a variant of acute disseminated encephalomyelitis. Indian journal of medical sciences, 2010, Volume: 64, Issue:12 Topics: Acyclovir; Anti-Inflammatory Agents; Anticonvulsants; Antiviral Agents; Brain; Child; Coma; Encephal	2010
An unusual case of relay pentobarbital toxicosis in a dog. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2011, Volume: 7, Issue:3 Topics: Adipose Tissue; Animals; Anticonvulsants; Coma; Dog Diseases; Dogs; Female; Gas Chromatography-Mass	2011
Pharmacoresistant convulsions and visual hallucinations around two weeks after selegiline overdose: a case report. Pharmacopsychiatry, 2011, Volume: 44, Issue:7 Topics: Anticonvulsants; Bipolar Disorder; Coma; Diazepam; Drug Overdose; Drug Resistance; Hallucinations; H	2011
[Effects of phenobarbital, acylureas and diphenylhydantoin on coma during electric epileptic crisis in guinea pig. II..]. Helvetica physiologica et pharmacologica acta, 1953, Volume: 11, Issue:3 Topics: Anticonvulsants; Barbiturates; Coma; Electricity; Epilepsy; Guinea Pigs; Phenobarbital; Phenytoin; S	1953
SOME OBSERVATIONS ON THE ELECTROGRAPHIC CORRELATES OF THE DECEREBRATE ATTACK. Electroencephalography and clinical neurophysiology, 1964, Volume: 16 Topics: Child; Coma; Decerebrate State; Electroencephalography; Epilepsy; Humans; Hypoxia, Brain; Infusions,	1964
INTERMITTENT CEREBRAL INSUFFICIENCY. REPORT OF CASE WITH COMPLETE CLINICAL RECOVERY BETWEEN EPISODES OF COMA. Geriatrics, 1965, Volume: 20 Topics: Arteriosclerosis; Autonomic Nerve Block; Carotid Artery Thrombosis; Cerebral Angiography; Cerebral I	1965
PROBENECID (BENEMID) INTOXICATION WITH STATUS EPILEPTICUS. The American journal of medicine, 1965, Volume: 38 Topics: Coma; Drug Therapy; Epilepsy; Gout; Phenobarbital; Phenytoin; Poisoning; Probenecid; Status Epilepti	1965
Studies on Dilantin intoxication. I. Ultrastructural analogies with the lipoidoses. Neurology, 1967, Volume: 17, Issue:5 Topics: Animals; Ataxia; Cerebellar Cortex; Coma; Cytoplasmic Granules; Lipidoses; Male; Microscopy, Electro	1967
Placebo-induced conversion reaction: a neurobehavioral and EEG study of hysterical aphasia, seizure, and coma. Journal of abnormal psychology, 1983, Volume: 92, Issue:2 Topics: Adult; Aphasia; Coma; Conversion Disorder; Female; Humans; Phenytoin; Seizures; Set, Psychology	1983
The brain amino acid pattern in experimental coma due to phenytoin in guinea pigs. Resuscitation, 1984, Volume: 11, Issue:1-2 Topics: Amino Acids; Animals; Brain; Chromatography, Ion Exchange; Coma; Guinea Pigs; Phenytoin	1984
Severe hypernatremic coma due to diphenylhydantoin intoxication. Clinical nephrology, 1983, Volume: 20, Issue:5 Topics: Adult; Coma; Epilepsy, Tonic-Clonic; Female; Humans; Hypernatremia; Phenytoin	1983
Importance of unbound phenytoin serum levels in head trauma patients. The Journal of trauma, 1983, Volume: 23, Issue:12 Topics: Adult; Coma; Craniocerebral Trauma; Epilepsy, Post-Traumatic; Humans; Immunoenzyme Techniques; Male;	1983
A prolonged severe intoxication after ingestion of phenytoin and phenobarbital. The Western journal of medicine, 1981, Volume: 135, Issue:5 Topics: Adult; Coma; Confusion; Female; Gastric Lavage; Humans; Nystagmus, Pathologic; Phenobarbital; Phenyt	1981
Propofol in the management of refractory status epilepticus: a case report. Intensive care medicine, 1994, Volume: 20, Issue:2 Topics: Clonazepam; Coma; Drug Therapy, Combination; Electroencephalography; Glasgow Coma Scale; Humans; Inf	1994
Periodic complexes, absence-like status and suppression-burst pattern in coma following cardiorespiratory arrest. Clinical EEG (electroencephalography), 1997, Volume: 28, Issue:2 Topics: Aged; Anticonvulsants; Brain; Coma; Diazepam; Electroencephalography; Epilepsy, Absence; Heart Arres	1997
[Influence of diphenylhydantoine on delta sharp-waves in coma. A clinical contribution (author's transl)]. EEG-EMG Zeitschrift fur Elektroenzephalographie, Elektromyographie und verwandte Gebiete, 1979, Volume: 10, Issue:3 Topics: Coma; Delta Rhythm; Humans; Male; Middle Aged; Narcotics; Phenytoin; Poisoning	1979
Phenytoin-induced ophthalmoplegia. Neurology, 1976, Volume: 26, Issue:11 Topics: Adolescent; Adult; Coma; Epilepsy, Tonic-Clonic; Humans; Male; Middle Aged; Ophthalmoplegia; Phenyto	1976
Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. Acta neurologica Scandinavica, 1992, Volume: 86, Issue:3 Topics: Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Atrophy; Carbamoyl-Phosphate Synthase (Ammonia	1992
[Pharmacological study of TJ-8007 (Tsumura-Zokumeito) (I): Protective effects of TJ-8007 against anoxic brain damage]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1987, Volume: 89, Issue:6 Topics: Animals; Brain Damage, Chronic; Coma; Drugs, Chinese Herbal; Hypoxia, Brain; Male; Medicine, Chinese	1987
Cerebral protection. British journal of hospital medicine, 1986, Volume: 35, Issue:5 Topics: Adrenal Cortex Hormones; Barbiturates; Blood Glucose; Brain Edema; Brain Ischemia; Calcium Channel B	1986
[Therapy in traumatic epilepsy]. Duodecim; laaketieteellinen aikakauskirja, 1971, Volume: 87, Issue:16 Topics: Adult; Barbiturates; Bromides; Carbamazepine; Coma; Disabled Persons; Drug Resistance; Epilepsy, Pos	1971
Methsuximide overdose. Delayed onset of profound coma. JAMA, 1973, Mar-26, Volume: 223, Issue:13 Topics: Administration, Oral; Adolescent; Anticonvulsants; Central Nervous System; Coma; Drug Synergism; Ele	1973
Prolonged unconsciousness following electroconvulsive therapy. The American journal of psychiatry, 1967, Volume: 124, Issue:1 Topics: Adult; Aged; Coma; Craniocerebral Trauma; Depression; Electroconvulsive Therapy; Epilepsies, Partial	1967
Chlormethiazole and trifluoperazine in alcohol withdrawal. The British journal of psychiatry : the journal of mental science, 1969, Volume: 115, Issue:527 Topics: Alcoholism; Chlormethiazole; Coma; Depression; Feeding and Eating Disorders; Female; Headache; Human	1969
Digoxin-phenytoin interaction. British medical journal, 1970, Apr-04, Volume: 2, Issue:5700 Topics: Ataxia; Cerebellar Diseases; Coma; Digoxin; Humans; Male; Middle Aged; Phenytoin	1970
Some properties of a coma producing material obtained from mammalian brain. Neuropharmacology, 1970, Volume: 9, Issue:3 Topics: Amylases; Animals; Blood Pressure; Brain Chemistry; Carbamazepine; Cats; Cerebral Cortex; Chromatogr	1970
Gas chromatographic assay of underivatized 5,5-diphenylhydantoin (dilantin) in plasma extracts. Clinical chemistry, 1971, Volume: 17, Issue:5 Topics: Carbamazepine; Chloroform; Chromatography, Gas; Coma; Epilepsy; Humans; Hydrogen-Ion Concentration;	1971
Acute diphenylhydantoin intoxication. American journal of diseases of children (1960), 1968, Volume: 116, Issue:4 Topics: Child, Preschool; Coma; Decerebrate State; Humans; Male; Peritoneal Dialysis; Phenytoin	1968
Hyperglycemic, nonketotic coma following administration of Dilantin (Diphenylhydantoin). Diabetes, 1969, Volume: 18, Issue:2 Topics: Animals; Blood Glucose; Blood Pressure; Coma; Dogs; Fatty Acids, Nonesterified; Humans; Hyperglycemi	1969

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