phenytoin has been researched along with Cognition Disorders in 46 studies
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This case report provides the first potential evidence that a low dose of phenytoin, a widely used and well tolerated anti-epileptic medication, may be capable of modifying the core social cognitive deficits associated with autism spectrum disorders." | 8.91 | The treatment of autism with low-dose phenytoin: a case report. ( Bird, PD, 2015) |
| "Cognitive impairment implicates many factors beyond phenytoin monotherapy in patients with epilepsy." | 7.79 | Association of apolipoprotein E ε4 allele with cognitive impairment in patients with epilepsy and interaction with phenytoin monotherapy. ( Ganesvaran, RA; Narmadha, MP; Palanisamy, A; Rajendran, NN, 2013) |
| "Phenytoin (PHT) is routinely used for seizure prophylaxis after subarachnoid hemorrhage (SAH), but may adversely affect neurologic and cognitive recovery." | 7.73 | Phenytoin exposure is associated with functional and cognitive disability after subarachnoid hemorrhage. ( Commichau, C; Connolly, ES; Fitzsimmons, BF; Janjua, N; Kreiter, KT; Mayer, SA; Naidech, AM; Ostapkovich, N; Parra, A, 2005) |
| "Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin." | 6.47 | Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011) |
| "This case report provides the first potential evidence that a low dose of phenytoin, a widely used and well tolerated anti-epileptic medication, may be capable of modifying the core social cognitive deficits associated with autism spectrum disorders." | 4.91 | The treatment of autism with low-dose phenytoin: a case report. ( Bird, PD, 2015) |
| "Cognitive impairment implicates many factors beyond phenytoin monotherapy in patients with epilepsy." | 3.79 | Association of apolipoprotein E ε4 allele with cognitive impairment in patients with epilepsy and interaction with phenytoin monotherapy. ( Ganesvaran, RA; Narmadha, MP; Palanisamy, A; Rajendran, NN, 2013) |
| "Despite similarities in hemorrhage type and severity at onset, patients receiving levetiracetam had better cognition at discharge and fewer seizures than patients receiving phenytoin." | 3.77 | Levetiracetam is associated with improved cognitive outcome for patients with intracranial hemorrhage. ( Ehtisham, A; Heinrichs, RJ; Janzen, JM; Taylor, S, 2011) |
| "On the basis of epileptic model induced by pentylenetetrazol (PTZ), cognitive impairment model was induced by kindling epilepsy with PTZ everyday, which were then di-vided into the model-1 group, the CZD-1 group, the nimodipine-1 group, and those by injecting large dosage phenytoin sodium were divided into the model-2 group, the CZD-2 group and the nimodipine-2 group." | 3.74 | [Influence of repeated seizures and large dosage anti-epileptic drug on phosphorylated cAMP response element binding protein in rat's hippocampus and effect of Caoguo Zhimu Decoction]. ( He, J; Ma, SL, 2007) |
| "Children exposed during pregnancy to the anticonvulsant drugs phenytoin, phenobarbital, and carbamazepine as monotherapy and polytherapy have an increased frequency of midface and digit hypoplasia." | 3.73 | The correlation of deficits in IQ with midface and digit hypoplasia in children exposed in utero to anticonvulsant drugs. ( Coull, BA; Dorfman, J; Holmes, LB; Rosenberger, PB, 2005) |
| "Phenytoin (PHT) is routinely used for seizure prophylaxis after subarachnoid hemorrhage (SAH), but may adversely affect neurologic and cognitive recovery." | 3.73 | Phenytoin exposure is associated with functional and cognitive disability after subarachnoid hemorrhage. ( Commichau, C; Connolly, ES; Fitzsimmons, BF; Janjua, N; Kreiter, KT; Mayer, SA; Naidech, AM; Ostapkovich, N; Parra, A, 2005) |
| " Statistical analyses showed that group 2 had a longer history of epilepsy with a consequently longer duration of phenytoin (PHT) consumption." | 3.67 | Role of the cerebellum in complex human behavior. ( Attig, E; Botez, MI; Botez, T; Elie, R, 1989) |
| "Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin." | 2.47 | Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011) |
| "Treatment with phenytoin per se and along with the flavonoid rich fraction showed significant reduction in seizure severity score as compared to vehicle control." | 1.43 | Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: A repertoire of Glycyrrhiza glabra flavonoid antioxidants. ( Goel, RK; Singh, D; Singh, P, 2016) |
| " Our findings strongly suggest that CoQ10 can be considered a safe and effective adjuvant to phenytoin therapy in epilepsy both to ameliorate seizure severity and to protect against seizure-induced oxidative damage by reducing the cognitive impairment and oxidative stress associated with chronic use of phenytoin." | 1.37 | Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress. ( Tawfik, MK, 2011) |
| " Chronic administration of phenytoin also produced significant elevations in brain MDA and reduction of brain GSH levels." | 1.35 | Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats. ( Gupta, YK; Mehla, J; Reeta, KH, 2009) |
| "In particular, memory deficits, attentional problems, psychomotor slowing and reading and writing difficulties are highlighted, and the impact of the seizures, brain damage, and anticonvulsant drugs on cognitive function noted." | 1.27 | [Cognitive effects of antiepileptic drugs]. ( Trimble, R, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (34.78) | 18.7374 |
| 1990's | 10 (21.74) | 18.2507 |
| 2000's | 11 (23.91) | 29.6817 |
| 2010's | 9 (19.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Verrotti, A | 1 |
| Scaparrotta, A | 1 |
| Cofini, M | 1 |
| Chiarelli, F | 1 |
| Tiboni, GM | 1 |
| Singh, P | 2 |
| Singh, D | 2 |
| Goel, RK | 2 |
| Bird, PD | 1 |
| Reeta, KH | 2 |
| Mehla, J | 1 |
| Gupta, YK | 2 |
| Taylor, S | 1 |
| Heinrichs, RJ | 1 |
| Janzen, JM | 1 |
| Ehtisham, A | 1 |
| Zhang, LL | 1 |
| Zeng, LN | 1 |
| Li, YP | 1 |
| Tawfik, MK | 1 |
| Pahuja, M | 1 |
| Kleekal, T | 1 |
| Tripathi, M | 1 |
| Palanisamy, A | 1 |
| Rajendran, NN | 1 |
| Narmadha, MP | 1 |
| Ganesvaran, RA | 1 |
| Ogura, H | 1 |
| Yasuda, M | 1 |
| Nakamura, S | 1 |
| Yamashita, H | 1 |
| Mikoshiba, K | 1 |
| Ohmori, H | 1 |
| Holmes, LB | 1 |
| Coull, BA | 1 |
| Dorfman, J | 1 |
| Rosenberger, PB | 1 |
| Naidech, AM | 1 |
| Kreiter, KT | 1 |
| Janjua, N | 1 |
| Ostapkovich, N | 1 |
| Parra, A | 1 |
| Commichau, C | 1 |
| Connolly, ES | 1 |
| Mayer, SA | 1 |
| Fitzsimmons, BF | 1 |
| Metlay, JP | 1 |
| Cohen, A | 1 |
| Polsky, D | 1 |
| Kimmel, SE | 1 |
| Koppel, R | 1 |
| Hennessy, S | 1 |
| Koch, S | 1 |
| Gidal, BE | 1 |
| Wong, GK | 1 |
| Poon, WS | 1 |
| He, J | 1 |
| Ma, SL | 1 |
| Thomas, P | 1 |
| Somerville, ER | 1 |
| Bruni, J | 1 |
| Dam, M | 1 |
| Andrewes, DG | 1 |
| Tomlinson, L | 1 |
| Elwes, RD | 1 |
| Reynolds, EH | 1 |
| Marescaux, C | 1 |
| Warter, JM | 1 |
| Micheletti, G | 1 |
| Rumbach, L | 1 |
| Coquillat, G | 1 |
| Kurtz, D | 1 |
| Vieweg, V | 1 |
| Pandurangi, A | 1 |
| Levenson, J | 1 |
| Silverman, J | 1 |
| Aldenkamp, AP | 2 |
| Alpherts, WC | 2 |
| Diepman, L | 1 |
| van 't Slot, B | 1 |
| Overweg, J | 1 |
| Vermeulen, J | 1 |
| Branford, D | 1 |
| Collacott, RA | 1 |
| Pulliainen, V | 1 |
| Jokelainen, M | 1 |
| Blennow, G | 1 |
| Elmqvist, D | 1 |
| Heijbel, J | 1 |
| Nilsson, HL | 1 |
| Sandstedt, P | 1 |
| Tonnby, B | 1 |
| Wåhlander, L | 1 |
| Wosse, E | 1 |
| Read, CL | 1 |
| Stephen, LJ | 1 |
| Stolarek, IH | 1 |
| Paul, A | 1 |
| Sills, GJ | 1 |
| Brodie, MJ | 1 |
| Pandhi, P | 1 |
| Balakrishnan, S | 1 |
| Vohora, D | 1 |
| Pal, SN | 1 |
| Pillai, KK | 1 |
| Tucha, O | 1 |
| Smely, C | 1 |
| Preier, M | 1 |
| Lange, KW | 1 |
| Kugoh, T | 1 |
| Hosokawa, K | 1 |
| Efabumuyi, OI | 1 |
| Jefries, JJ | 1 |
| Fisher, D | 1 |
| DiMino, JM | 1 |
| Gallassi, R | 1 |
| Morreale, A | 1 |
| Di Sarro, R | 1 |
| Marra, M | 1 |
| Lugaresi, E | 1 |
| Baruzzi, A | 1 |
| Teta, D | 1 |
| Uldry, PA | 1 |
| Regli, F | 1 |
| Trimble, MR | 2 |
| Botez, MI | 1 |
| Botez, T | 1 |
| Elie, R | 1 |
| Attig, E | 1 |
| Ramsay, RE | 1 |
| Trimble, R | 1 |
| Geering, JM | 1 |
| Ruch, W | 1 |
| Dettli, L | 1 |
| Riley, CG | 1 |
| Boelhouwer, C | 1 |
| Henry, CE | 1 |
| Glueck, BC | 1 |
| Douglas, EF | 1 |
| White, PT | 1 |
| Nelson, JW | 1 |
| Zlotlow, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness and Utility of a Virtual Custom Tool to Reduce the Medication Errors of Patients Older Than 65 Years Pluripatologic With Complex Therapeutic Regimens[NCT02071498] | 99 participants (Actual) | Interventional | 2012-06-30 | Completed | |||
| The Diagnosis and Management of Patients With Epilepsy: Nationwide, Multicenter Study of Recordings for the Diagnosis and Management of Patients With Epilepsy and Treatment With Levetiracetam in Daily Clinical Practice in Greece[NCT02356731] | 450 participants (Actual) | Observational | 2015-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for phenytoin and Cognition Disorders
| Article | Year |
|---|---|
Developmental neurotoxicity and anticonvulsant drugs: a possible link.
Topics: Animals; Anticonvulsants; Breast Feeding; Carbamazepine; Cognition Disorders; Developmental Disabili | 2014 |
The treatment of autism with low-dose phenytoin: a case report.
Topics: Adult; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Cognition | 2015 |
Side effects of phenobarbital in epilepsy: a systematic review.
Topics: Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Cohort Studies; Cross-Over Studies; Data | 2011 |
How urgent is the treatment of nonconvulsive status epilepticus?
Topics: Adult; Animals; Anticonvulsants; Benzodiazepines; Child; Cognition Disorders; Disease Models, Animal | 2007 |
The consulting psychiatrist and the polydipsia-hyponatremia syndrome in schizophrenia.
Topics: Angiotensin II; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Carbamazepine; Cognit | 1994 |
Antiepileptic drugs, cognitive function, and behavior in children: evidence from recent studies.
Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Cognition; Cognition Disorders; Epilepsy; | 1990 |
Use of phenytoin and carbamazepine in treatment of epilepsy.
Topics: Anemia, Aplastic; Carbamazepine; Cerebellar Ataxia; Chemical and Drug Induced Liver Injury; Cognitio | 1986 |
Anticonvulsant drugs and cognitive function: a review of the literature.
Topics: Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Epilepsy; Humans; Phenobarbital; Phe | 1987 |
6 trials available for phenytoin and Cognition Disorders
| Article | Year |
|---|---|
Interaction profile of Zizyphus jujuba with phenytoin, phenobarbitone, and carbamazepine in maximal electroshock-induced seizures in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Chi-Square Distribution; Chromat | 2012 |
Cognitive side-effects of phenytoin compared with carbamazepine in patients with localization-related epilepsy.
Topics: Adolescent; Adult; Attention; Carbamazepine; Cognition Disorders; Epilepsy; Female; Humans; Male; Me | 1994 |
Effects of phenytoin and carbamazepine on cognitive functions in newly diagnosed epileptic patients.
Topics: Adult; Carbamazepine; Cognition Disorders; Epilepsy; Female; Follow-Up Studies; Humans; Learning; Ma | 1994 |
Withdrawal of antiepileptic medication in children--effects on cognitive function: The Multicenter Holmfrid Study.
Topics: Adolescent; Carbamazepine; Child; Cognition; Cognition Disorders; Epilepsy; Female; Follow-Up Studie | 1993 |
Cognitive effects of anticonvulsant monotherapy in elderly patients: a placebo-controlled study.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Cognition Disorders; Dose-Response Relation | 1998 |
Positive spiking: a double-blind control study on its significance in behavior disorders, both diagnostically and therapeutically.
Topics: Adolescent; Adult; Affective Symptoms; Bender-Gestalt Test; Clinical Trials as Topic; Cognition Diso | 1968 |
32 other studies available for phenytoin and Cognition Disorders
| Article | Year |
|---|---|
Ficus religiosa L. figs--a potential herbal adjuvant to phenytoin for improved management of epilepsy and associated behavioral comorbidities.
Topics: Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Cognition Disorders; Comorbidity; Depressi | 2014 |
Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: A repertoire of Glycyrrhiza glabra flavonoid antioxidants.
Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Brain; Cognition; Cognition Diso | 2016 |
Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Avoidance L | 2009 |
Levetiracetam is associated with improved cognitive outcome for patients with intracranial hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Cognition Disorders; Female; Humans; Intracranial H | 2011 |
Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress.
Topics: Analysis of Variance; Animals; Anticonvulsants; Avoidance Learning; Catalase; Cognition Disorders; D | 2011 |
Association of apolipoprotein E ε4 allele with cognitive impairment in patients with epilepsy and interaction with phenytoin monotherapy.
Topics: Adult; Anticonvulsants; Apolipoprotein E4; Case-Control Studies; Cholesterol; Cognition Disorders; E | 2013 |
Neurotoxic damage of granule cells in the dentate gyrus and the cerebellum and cognitive deficit following neonatal administration of phenytoin in mice.
Topics: Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Body Weight; Cerebellum; Cognition Disorders; | 2002 |
The correlation of deficits in IQ with midface and digit hypoplasia in children exposed in utero to anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Face; Facie | 2005 |
Phenytoin exposure is associated with functional and cognitive disability after subarachnoid hemorrhage.
Topics: Cognition Disorders; Female; Follow-Up Studies; Hospitalization; Humans; Length of Stay; Male; Middl | 2005 |
Medication safety in older adults: home-based practice patterns.
Topics: Aged; Aged, 80 and over; Cognition Disorders; Cohort Studies; Digoxin; Female; Health Behavior; Heal | 2005 |
Phenytoin and cognitive decline.
Topics: Anticonvulsants; Area Under Curve; Calcium Channel Blockers; Cognition Disorders; Cytochrome P-450 E | 2005 |
Use of phenytoin and other anticonvulsant prophylaxis in patients with aneurysmal subarachnoid hemorrhage.
Topics: Cognition Disorders; Drug Interactions; Humans; Intracranial Aneurysm; Nimodipine; Phenytoin; Seizur | 2005 |
[Influence of repeated seizures and large dosage anti-epileptic drug on phosphorylated cAMP response element binding protein in rat's hippocampus and effect of Caoguo Zhimu Decoction].
Topics: Animals; Cognition Disorders; Cyclic AMP Response Element-Binding Protein; Drugs, Chinese Herbal; Ep | 2007 |
Tonic status epilepticus presenting as confusional state.
Topics: Adolescent; Cognition Disorders; Confusion; Diazepam; Electroencephalography; Humans; Male; Methylph | 1983 |
Summing up of the success so far gained through choice of drugs or combinations of drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Cognition Disorders; Drug Therapy, Combination; Epilepsy; Hum | 1984 |
The influence of carbamazepine and phenytoin on memory and other aspects of cognitive function in new referrals with epilepsy.
Topics: Adolescent; Adult; Aged; Carbamazepine; Cognition Disorders; Decision Making; Epilepsy; Fixation, Oc | 1984 |
Stuporous episodes during treatment with sodium valproate: report of seven cases.
Topics: Anticonvulsants; Cognition Disorders; Consciousness Disorders; Electroencephalography; Epilepsy; Fem | 1982 |
Comparison of community and institutional prescription of antiepileptic drugs for individuals with learning disabilities.
Topics: Adult; Ambulatory Care; Anticonvulsants; Cognition Disorders; Day Care, Medical; Drug Therapy, Combi | 1994 |
Cognitive dysfunction induced by phenytoin and valproate in rats: effect of nitric oxide.
Topics: Animals; Anticonvulsants; Arginine; Cognition Disorders; Enzyme Inhibitors; Female; Male; Memory; Ni | 1999 |
Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant.
Topics: Animals; Anticonvulsants; Avoidance Learning; Cognition Disorders; Electroshock; India; Male; Mice; | 2000 |
Cognitive deficits before treatment among patients with brain tumors.
Topics: Adult; Aged; Aging; Anticonvulsants; Brain Edema; Brain Neoplasms; Cognition; Cognition Disorders; D | 2000 |
Mental dullness associated with left frontal continuous focal discharge.
Topics: Adult; Carbamazepine; Cognition Disorders; Electroencephalography; Epilepsy, Post-Traumatic; Frontal | 1977 |
Treatment of drug-induced psychosis with diphenylhydantoin.
Topics: Adult; Cognition Disorders; Female; Hallucinations; Hallucinogens; Humans; Illusions; Male; Phenytoi | 1976 |
Case presentation of an alternative therapeutic approach for the borderline psychotic heroin addict: diphenylhydantoin.
Topics: Adult; Cognition Disorders; Heroin Dependence; Humans; Male; Phenytoin; Psychotherapy; Psychotic Dis | 1975 |
Cognitive effects of antiepileptic drug discontinuation.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Epilepsy; Humans; | 1992 |
[Reversible ophthalmoplegia, cerebellar syndrome and vigilance disorders following phenytoin poisoning].
Topics: Adult; Cerebellar Ataxia; Charcoal; Cognition Disorders; Humans; Male; Ophthalmoplegia; Phenytoin; P | 1990 |
Role of the cerebellum in complex human behavior.
Topics: Adult; Atrophy; Behavior; Cerebellum; Cognition Disorders; Epilepsy; Humans; Intelligence Tests; Neu | 1989 |
[Cognitive effects of antiepileptic drugs].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cognition Disorders; Epilepsy; | 1987 |
[Diphenylhydantoin poisoning due to diphenylhydantoin-isoniazid interaction].
Topics: Adult; Cognition Disorders; Drug Interactions; Epilepsy; Fatigue; Humans; Isoniazid; Male; Middle Ag | 1974 |
Chronic hydantoin intoxication: case report.
Topics: Adult; Cerebellar Ataxia; Cognition Disorders; Epilepsy; Female; Humans; Nystagmus, Pathologic; Phen | 1972 |
Three per second spike-wave in digitalis toxicity. Report of a case.
Topics: Aged; Brain; Cerebral Cortex; Cognition Disorders; Digitalis Glycosides; Digoxin; Electroencephalogr | 1971 |
Temporal lobe "spike focus" associated with confusion, complete amnesia and fugues in a paranoid schizophrenic.
Topics: Adult; Amnesia; Chlorpromazine; Cognition Disorders; Dissociative Disorders; Electroencephalography; | 1968 |