phenytoin has been researched along with Cleft Palate in 80 studies
Cleft Palate: Congenital fissure of the soft and/or hard palate, due to faulty fusion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The production of cleft palate by glucocorticoids and phenytoin is a complicated interference in a complex developmental program involving many genetic and biochemical processes." | 8.76 | Biochemical mechanism of glucocorticoid-and phenytoin-induced cleft palate. ( Goldman, AS, 1984) |
| "Our previous genome-wide Quantitative Trait Locus (QTL) mapping study using mouse A/J by C57BL/6J recombinant inbred (RI) lines suggested several chromosomal regions contain genes influencing susceptibility to phenytoin (PT)-induced cleft lip with or without cleft palate [CL(P)] and 6-aminonicotinamide (6-AN)-induced isolated cleft palate (CP)." | 7.73 | Correlation of susceptibility to 6-aminonicotinamide and hydrocortisone-induced cleft palate. ( Diehl, SR; Erickson, RP; Karolyi, IJ, 2005) |
| "There are many reports that the teratogenic effects of phenytoin, especially cleft palate can be decreased by stimulation of maternal immune system." | 7.73 | A comparison study of effects of Echinacea extract and levamisole on phenytoin-induced cleft palate in mice. ( Arzi, A; Khaksary Mahabady, M; Najafzadeh, H; Papahn, AA; Ranjbar, R, 2006) |
| "Both phenytoin (PHT) and glucocorticoid (GC) have been reported to be an effective teratogen for the production of cleft palate." | 7.67 | The relation between phenytoin-receptor and glucocorticoid in the induction of cleft palate with phenytoin in mice. ( Inayoshi, K; Kurisu, K; Nagata, K; Ohsaki, Y, 1989) |
| "Pregnant female mice of various congenic strains were injected on days 11 through 14 of gestation with phenytoin, and the fetuses were examined for the occurrence of cleft palate." | 7.66 | Susceptibility to phenytoin-induced cleft palate in mice is influenced by genes linked to H-2 and H-3. ( Baker, MK; Gasser, DL; Goldman, AS, 1983) |
| "Phenytoin administered to pregnant mice during the critical embryonic period of palatal differentiation produced 50% cleft palates in the Ajax (A/J) strain compared to 1." | 7.66 | Susceptibility of mice to phenytoin-induced cleft palate correlated with inhibition of fetal palatal RNA and protein synthesis (41255). ( Goldman, AS; Sonawane, BR, 1981) |
| "High incidences of cleft lip and palate (CLP) produced by maternal intraperitoneal administration of 75 mg/kg phenytoin on gestational day 10 to A/J mice are associated with a severe size reduction in the lateral nasal process." | 7.66 | Phenytoin (dilantin)-induced cleft lip and palate in A/J mice: a scanning and transmission electron microscopic study. ( Ambrose, LJ; Dorgan, D; Johnston, MC; Sulik, KK, 1979) |
| "Malignant mesenchymoma developed in an 18-year-old patient with phenytoin-associated cleft lip and palate." | 7.65 | Malignant mesenchymoma and birth defects. Prenatal exposure to phenytoin. ( Blattner, WA; Fraumeni, JF; Henson, DE; Young, RC, 1977) |
| " Embryonic heart rate was also recorded on individual days after dosing days 9-16." | 5.31 | Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage. ( Azarbayjani, F; Danielsson, BR, 2001) |
| "The production of cleft palate by glucocorticoids and phenytoin is a complicated interference of a complex developmental program involving many genetic and biochemical processes." | 4.77 | Palatal development and the arachidonic acid cascade. ( Goldman, AS; Piddington, RL, 1985) |
| "Evidence has been presented that there is a quantitative variation of fetal palatal glucocorticoid receptor levels which correlates with susceptibility to cortisone-induced cleft palate in a variety of inbred strains of mice." | 4.76 | Quantitative variation in hormonal receptors and clefting in the mouse. ( Goldman, AS; Katsumata, M, 1980) |
| "The production of cleft palate by glucocorticoids and phenytoin is a complicated interference in a complex developmental program involving many genetic and biochemical processes." | 4.76 | Biochemical mechanism of glucocorticoid-and phenytoin-induced cleft palate. ( Goldman, AS, 1984) |
| "An increased risk for isolated CL/P was found in cases born to mothers treated with amoxicillin, phenytoin, oxprenolol, and thiethylperazine during the second and third month of pregnancy, i." | 3.74 | Drug treatment during pregnancy and isolated orofacial clefts in hungary. ( Czeizel, AE; Métneki, J; Puhó, EH; Szunyogh, M, 2007) |
| "Our previous genome-wide Quantitative Trait Locus (QTL) mapping study using mouse A/J by C57BL/6J recombinant inbred (RI) lines suggested several chromosomal regions contain genes influencing susceptibility to phenytoin (PT)-induced cleft lip with or without cleft palate [CL(P)] and 6-aminonicotinamide (6-AN)-induced isolated cleft palate (CP)." | 3.73 | Correlation of susceptibility to 6-aminonicotinamide and hydrocortisone-induced cleft palate. ( Diehl, SR; Erickson, RP; Karolyi, IJ, 2005) |
| "There are many reports that the teratogenic effects of phenytoin, especially cleft palate can be decreased by stimulation of maternal immune system." | 3.73 | A comparison study of effects of Echinacea extract and levamisole on phenytoin-induced cleft palate in mice. ( Arzi, A; Khaksary Mahabady, M; Najafzadeh, H; Papahn, AA; Ranjbar, R, 2006) |
| " In an animal model of phenytoin-induced cleft palate, we report that Hoxa-2 mRNA and protein expression were significantly decreased, implicating a possible functional role of the Hoxa-2 gene in the development of phenytoin-induced cleft palate." | 3.70 | Temporal and spatial expression of Hoxa-2 during murine palatogenesis. ( Hao, Z; Leung, V; Nazarali, A; Puthucode, R; Wolf, L; Yeung, J, 2000) |
| " We compare results obtained using phenytoin (which induces cleft lip) and 6-aminonicotinamide (which induces cleft palate)." | 3.69 | Genome scan for teratogen-induced clefting susceptibility loci in the mouse: evidence of both allelic and locus heterogeneity distinguishing cleft lip and cleft palate. ( Diehl, SR; Erickson, RP, 1997) |
| " 6-Aminonicotinamide-induced cleft palate and phenytoin-induced cleft lip with or without cleft palate are also influenced by this genetic region but not as strongly." | 3.68 | Major effects on teratogen-induced facial clefting in mice determined by a single genetic region. ( Erickson, RP; Karolyi, J; Killewald, L; Liu, S, 1990) |
| "Both phenytoin (PHT) and glucocorticoid (GC) have been reported to be an effective teratogen for the production of cleft palate." | 3.67 | The relation between phenytoin-receptor and glucocorticoid in the induction of cleft palate with phenytoin in mice. ( Inayoshi, K; Kurisu, K; Nagata, K; Ohsaki, Y, 1989) |
| "Pregnant female mice of various congenic strains were injected on days 11 through 14 of gestation with phenytoin, and the fetuses were examined for the occurrence of cleft palate." | 3.66 | Susceptibility to phenytoin-induced cleft palate in mice is influenced by genes linked to H-2 and H-3. ( Baker, MK; Gasser, DL; Goldman, AS, 1983) |
| "Inbred and congenic strains of mice have been studied for susceptibility to phenytoin-induced cleft lip with or without cleft palate (CLP) and isolated cleft palate (CP)." | 3.66 | Phenytoin teratogenicity in the primary and secondary mouse embryonic palate is influenced by the H-2 histocompatibility locus. ( Baker, MK; Fishman, CL; Goldman, AS, 1983) |
| "High incidences of cleft lip and palate (CLP) produced by maternal intraperitoneal administration of 75 mg/kg phenytoin on gestational day 10 to A/J mice are associated with a severe size reduction in the lateral nasal process." | 3.66 | Phenytoin (dilantin)-induced cleft lip and palate in A/J mice: a scanning and transmission electron microscopic study. ( Ambrose, LJ; Dorgan, D; Johnston, MC; Sulik, KK, 1979) |
| "Phenytoin administered to pregnant mice during the critical embryonic period of palatal differentiation produced 50% cleft palates in the Ajax (A/J) strain compared to 1." | 3.66 | Susceptibility of mice to phenytoin-induced cleft palate correlated with inhibition of fetal palatal RNA and protein synthesis (41255). ( Goldman, AS; Sonawane, BR, 1981) |
| "Malignant mesenchymoma developed in an 18-year-old patient with phenytoin-associated cleft lip and palate." | 3.65 | Malignant mesenchymoma and birth defects. Prenatal exposure to phenytoin. ( Blattner, WA; Fraumeni, JF; Henson, DE; Young, RC, 1977) |
| " In the Hungarian Congenital Malformation Register use of the anticonvulsants diazepam and phenobarbiturates during pregnancy was determined in infants delivered with cleft lip with or without cleft palate, posterior cleft palate and, as a control, anencephaly and spina bifida." | 3.65 | A teratological evaluation of anticonvulsant drugs. ( Czeizel, E; Lakos, P, 1977) |
| "Fluconazole (FCZ) is an antifungal bis-triazole with potent inhibitory effect on the principal CYP-dependent metabolic pathway of PHT." | 2.69 | Teratological interaction between the bis-triazole antifungal agent fluconazole and the anticonvulsant drug phenytoin. ( Bellati, U; Di Ilio, C; Giampietro, F; Iammarrone, E; Lamonaca, D; Tiboni, GM, 1999) |
| "We have chosen to study the role of genetic susceptibility to teratogen-induced orofacial clefting, using 2 drugs (dilantin and corticosteroid) and 1 nondrug teratogen (6-aminonicotinamide)." | 2.46 | Genes, environment, and orofacial clefting: N-acetyltransferase and folic acid. ( Erickson, RP, 2010) |
| "Valproic acid is an anticonvulsant that has been associated with open neural tube defects." | 2.38 | Valproic acid prenatal exposure. Association with lipomyelomeningocele. ( Carter, BS; Stewart, JM, 1989) |
| "Cleft palate is among the most frequent congenital defects in humans." | 1.62 | ( Habu, M; Kataoka, S; Matsuyama, K; Nakatomi, M; Park, J; Peters, H; Sasaguri, M; Seta, Y; Takahashi, O; Tominaga, K; Toyono, T; Yoshiga, D, 2021) |
| "Cleft palate is one of the most common birth defects." | 1.37 | Effects of phenytoin and Echinacea purpurea extract on proliferation and apoptosis of mouse embryonic palatal mesenchymal cells. ( Chen, Z; Hu, X; Mao, X; Tang, S, 2011) |
| "Phenytoin (PHT) is a risk factor of cleft palate formation; however, the molecular mechanisms by which phenytoin exerts its teratogenic effects resulting in cleft palate remain unknown." | 1.36 | Effects of phenytoin on Satb2 and Hoxa2 gene expressions in mouse embryonic craniofacial tissue. ( Mao, XY; Tang, SJ, 2010) |
| "Fluconazole (FCZ) is a potent inhibitor of the cytochrome P450 (CYP)-mediated metabolism of the anti-epileptic agent phenytoin (PHT), a well-known human and animal teratogen." | 1.32 | Additional investigation on the potentiation of phenytoin teratogenicity by fluconazole. ( Angelucci, S; Bellati, U; Di Ilio, C; Giampietro, F; Moio, P; Tiboni, GM, 2003) |
| " Embryonic heart rate was also recorded on individual days after dosing days 9-16." | 1.31 | Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage. ( Azarbayjani, F; Danielsson, BR, 2001) |
| " Previous work had demonstrated that PHT treatment significantly increased endogenous maternal corticosterone concentrations for approximately 48 hr after dosing in A/J mice." | 1.28 | Embryotoxicity of phenytoin in adrenalectomized CD-1 mice. ( Branham, WS; Hansen, DK; Holson, RR; Sheehan, DM, 1992) |
| "Dimethadione was given similarly on Days 11 and 12, or 12 and 13, in a dose (900 mg/kg ip) that was equimolar to 1000 mg/kg of trimethadione." | 1.28 | Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds. ( Greco, GS; Nagai, MK; Wells, PG, 1989) |
| "Phenytoin, 55 mg/kg, was administered intraperitoneally (ip) to pregnant CD-1 mice at 0900 hr on gestational days 12 and 13." | 1.28 | Enhancement of murine phenytoin teratogenicity by the gamma-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine and by the glutathione depletor diethyl maleate. ( Helston, LM; Wells, PG; Wong, M, 1989) |
| "Acetaminophen pretreatment caused a threefold increase in phenytoin-induced fetal cleft palates without increasing resorptions." | 1.27 | Pharmacological studies on the potentiation of phenytoin teratogenicity by acetaminophen. ( Lum, JT; Wells, PG, 1986) |
| "The incidence of malformations in fetal mice exposed to phenytoin depends on drug dosage and the strain of mice." | 1.26 | Teratogenic effects of anticonvulsants. ( Paulson, GW; Paulson, RB, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 59 (73.75) | 18.7374 |
| 1990's | 7 (8.75) | 18.2507 |
| 2000's | 8 (10.00) | 29.6817 |
| 2010's | 4 (5.00) | 24.3611 |
| 2020's | 2 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Tsukiboshi, Y | 1 |
| Ogata, A | 1 |
| Noguchi, A | 1 |
| Mikami, Y | 1 |
| Yokota, S | 1 |
| Ogata, K | 1 |
| Yoshioka, H | 1 |
| Abdollahi Fakhim, S | 1 |
| Nouri-Vaskeh, M | 1 |
| Fakhriniya, MA | 1 |
| Park, J | 1 |
| Nakatomi, M | 1 |
| Sasaguri, M | 1 |
| Habu, M | 1 |
| Takahashi, O | 1 |
| Yoshiga, D | 1 |
| Matsuyama, K | 1 |
| Kataoka, S | 1 |
| Toyono, T | 1 |
| Seta, Y | 1 |
| Peters, H | 1 |
| Tominaga, K | 1 |
| Mao, XY | 1 |
| Tang, SJ | 1 |
| Erickson, RP | 6 |
| Hu, X | 1 |
| Chen, Z | 1 |
| Mao, X | 1 |
| Tang, S | 1 |
| Tiboni, GM | 3 |
| Giampietro, F | 2 |
| Angelucci, S | 1 |
| Moio, P | 1 |
| Bellati, U | 2 |
| Di Ilio, C | 3 |
| Karolyi, IJ | 2 |
| Diehl, SR | 2 |
| Khaksary Mahabady, M | 1 |
| Ranjbar, R | 1 |
| Arzi, A | 1 |
| Papahn, AA | 1 |
| Najafzadeh, H | 1 |
| Puhó, EH | 1 |
| Szunyogh, M | 1 |
| Métneki, J | 1 |
| Czeizel, AE | 1 |
| Cao, W | 1 |
| Acuña, DK | 1 |
| Strnatka, DW | 1 |
| Hunter, RJ | 1 |
| Chau, BT | 1 |
| Wakefield, LV | 1 |
| Sim, E | 1 |
| McQueen, CA | 1 |
| Sonawane, BR | 1 |
| Goldman, AS | 9 |
| Hansen, DK | 3 |
| Hodes, ME | 1 |
| Wells, PG | 5 |
| Paulson, GW | 2 |
| Paulson, RB | 2 |
| Fishman, CL | 1 |
| Baker, MK | 4 |
| Gasser, DL | 1 |
| Katsumata, M | 2 |
| Gupta, C | 1 |
| Sussdorf, CE | 1 |
| Maeda, K | 1 |
| Shimizu, H | 1 |
| Satomi, N | 1 |
| Endo, K | 1 |
| Hashiba, M | 1 |
| Shimoji, K | 1 |
| Tomassini, N | 1 |
| Hummeler, K | 1 |
| Nakane, Y | 1 |
| Millicovsky, G | 1 |
| Johnston, MC | 2 |
| McDevitt, JM | 1 |
| Gautieri, RF | 1 |
| Mann, DE | 1 |
| Marks, P | 1 |
| Mills, B | 1 |
| West, L | 1 |
| Bosi, G | 1 |
| Evangelisti, R | 1 |
| Valeno, V | 1 |
| Carinci, F | 1 |
| Pezzetti, F | 1 |
| Calastrini, C | 1 |
| Bodo, M | 1 |
| Carinci, P | 1 |
| Iammarrone, E | 2 |
| Lamonaca, D | 1 |
| Nazarali, A | 1 |
| Puthucode, R | 1 |
| Leung, V | 1 |
| Wolf, L | 1 |
| Hao, Z | 1 |
| Yeung, J | 1 |
| Amicarelli, F | 1 |
| Colafarina, S | 1 |
| Bonfigli, A | 1 |
| Miranda, M | 1 |
| Azarbayjani, F | 1 |
| Danielsson, BR | 1 |
| Czeizel, A | 1 |
| Walker, BE | 1 |
| Friis, ML | 1 |
| Sulik, KK | 1 |
| Ambrose, LJ | 1 |
| Dorgan, D | 1 |
| Jreissaty, S | 1 |
| Blattner, WA | 1 |
| Henson, DE | 1 |
| Young, RC | 1 |
| Fraumeni, JF | 1 |
| Lakos, P | 1 |
| Czeizel, E | 1 |
| Anderson, RC | 1 |
| Fritz, H | 1 |
| Sullivan, FM | 1 |
| McElhatton, PR | 1 |
| Miller, RP | 1 |
| Becker, BA | 4 |
| Husquinet, H | 1 |
| Biale, Y | 1 |
| Lewenthal, H | 1 |
| Aderet, NB | 1 |
| Annegers, JF | 2 |
| Elveback, LR | 2 |
| Hauser, WA | 2 |
| Kurland, LT | 2 |
| Branham, WS | 1 |
| Sheehan, DM | 1 |
| Holson, RR | 1 |
| Durner, M | 1 |
| Greenberg, DA | 1 |
| Delgado-Escueta, AV | 1 |
| Karolyi, J | 1 |
| Liu, S | 2 |
| Killewald, L | 1 |
| Carter, BS | 1 |
| Stewart, JM | 1 |
| Inayoshi, K | 1 |
| Ohsaki, Y | 1 |
| Nagata, K | 1 |
| Kurisu, K | 1 |
| Lambotte-Vandepaer, M | 1 |
| Brams, A | 1 |
| Crutzen-Fayt, MC | 1 |
| Duverger-Van Bogaert, M | 1 |
| Dumont, P | 1 |
| Léonard, A | 1 |
| Nagai, MK | 1 |
| Greco, GS | 1 |
| Wong, M | 2 |
| Helston, LM | 1 |
| Herold, R | 1 |
| Piddington, R | 1 |
| Billings, RE | 1 |
| Lum, JT | 1 |
| Niebyl, JR | 1 |
| Blake, DA | 1 |
| Rocco, LE | 1 |
| Baumgardner, R | 1 |
| Mellits, ED | 1 |
| Brown, KS | 1 |
| Evans, MI | 1 |
| Harne, LC | 1 |
| Piddington, RL | 1 |
| McClain, RM | 1 |
| Rohrs, JM | 1 |
| Lowe, CR | 1 |
| Elshove, J | 3 |
| Poswillo, D | 1 |
| Fraser, FC | 1 |
| Baratieri, A | 1 |
| Gagliardi, V | 1 |
| Simonetti, E | 1 |
| Schardein, JL | 1 |
| Dresner, AJ | 1 |
| Hentz, DL | 1 |
| Petrere, JA | 1 |
| Fitzgerald, JE | 1 |
| Kurtz, SM | 1 |
| Hill, RM | 1 |
| Meyer, JG | 1 |
| Mirkin, BL | 1 |
| Harbison, RD | 2 |
| Fahey, WJ | 1 |
| van Eck, JH | 1 |
| Gibson, JE | 1 |
| Massey, KM | 1 |
6 reviews available for phenytoin and Cleft Palate
| Article | Year |
|---|---|
Genes, environment, and orofacial clefting: N-acetyltransferase and folic acid.
Topics: 6-Aminonicotinamide; Animals; Arylamine N-Acetyltransferase; Cleft Lip; Cleft Palate; Disease Models | 2010 |
Biochemical mechanism of glucocorticoid-and phenytoin-induced cleft palate.
Topics: Animals; Arachidonic Acids; Cell Survival; Chromosomes; Cleft Palate; Disease Susceptibility; Female | 1984 |
Quantitative variation in hormonal receptors and clefting in the mouse.
Topics: Animals; Cleft Palate; Cortisone; Dexamethasone; Disease Models, Animal; Disease Susceptibility; HLA | 1980 |
Is there a genetic relationship between epilepsy and birth defects?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Congenital Abnormalities; Dis | 1992 |
Valproic acid prenatal exposure. Association with lipomyelomeningocele.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Cleft Palate; Female; | 1989 |
Palatal development and the arachidonic acid cascade.
Topics: Animals; Arachidonic Acids; Cell Survival; Cleft Palate; Disease Susceptibility; Glucocorticoids; Mi | 1985 |
2 trials available for phenytoin and Cleft Palate
| Article | Year |
|---|---|
Effects of phenytoin spray in prevention of fistula formation following cleft palate repair.
Topics: Cleft Palate; Female; Humans; Infant; Male; Oral Fistula; Phenytoin; Postoperative Complications; Tr | 2019 |
Teratological interaction between the bis-triazole antifungal agent fluconazole and the anticonvulsant drug phenytoin.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Antifungal Agents; Body Weight; Cleft Palate; | 1999 |
72 other studies available for phenytoin and Cleft Palate
| Article | Year |
|---|---|
Sasa veitchii extracts protect phenytoin-induced cell proliferation inhibition in human lip mesenchymal cells through modulation of miR-27b-5p.
Topics: Cell Proliferation; Child; Cleft Lip; Cleft Palate; Female; Humans; MicroRNAs; Phenytoin; Pregnancy; | 2023 |
Topics: Animals; Cleft Palate; Mice; MSX1 Transcription Factor; Oxidative Stress; Palate; Phenytoin; Signal | 2021 |
Effects of phenytoin on Satb2 and Hoxa2 gene expressions in mouse embryonic craniofacial tissue.
Topics: Animals; Anticonvulsants; Cleft Lip; Cleft Palate; Embryo, Mammalian; Face; Female; Fetus; Gene Expr | 2010 |
Effects of phenytoin and Echinacea purpurea extract on proliferation and apoptosis of mouse embryonic palatal mesenchymal cells.
Topics: Animals; Anticonvulsants; Apoptosis; Cell Cycle; Cell Proliferation; Cleft Palate; Cytoprotection; E | 2011 |
Additional investigation on the potentiation of phenytoin teratogenicity by fluconazole.
Topics: Animals; Chromatography, High Pressure Liquid; Cleft Palate; Dose-Response Relationship, Drug; Drug | 2003 |
Correlation of susceptibility to 6-aminonicotinamide and hydrocortisone-induced cleft palate.
Topics: 6-Aminonicotinamide; Animals; Cleft Palate; Disease Susceptibility; Female; Fetus; Hydrocortisone; M | 2005 |
A comparison study of effects of Echinacea extract and levamisole on phenytoin-induced cleft palate in mice.
Topics: Animals; Biometry; Body Weight; Cleft Palate; Echinacea; Female; Fetus; Levamisole; Male; Maternal E | 2006 |
Drug treatment during pregnancy and isolated orofacial clefts in hungary.
Topics: Abnormalities, Drug-Induced; Adrenergic beta-Antagonists; Amoxicillin; Anti-Bacterial Agents; Antico | 2007 |
Confirmation of the role of N-acetyltransferase 2 in teratogen-induced cleft palate using transgenics and knockouts.
Topics: 6-Aminonicotinamide; Animals; Arylamine N-Acetyltransferase; Base Sequence; Cleft Lip; Cleft Palate; | 2008 |
Susceptibility of mice to phenytoin-induced cleft palate correlated with inhibition of fetal palatal RNA and protein synthesis (41255).
Topics: Animals; Cleft Palate; Female; Fetus; Mice; Mice, Inbred Strains; Palate; Phenytoin; Pregnancy; Prot | 1981 |
Comparative teratogenicity of phenytoin among several inbred strains of mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Dose-Response Relationship, Drug; Fem | 1983 |
Physiological and environmental determinants of phenytoin teratogenicity: relation to glutathione homeostasis, and potentiation by acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Cleft Palate; Drug Synergism; Female; Fetal Resorption; Glut | 1983 |
Teratogenic effects of anticonvulsants.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Cleft Palate; Eyelid Diseases; | 1981 |
Phenytoin teratogenicity in the primary and secondary mouse embryonic palate is influenced by the H-2 histocompatibility locus.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Disease Susceptibility; Female; H-2 A | 1983 |
Susceptibility to phenytoin-induced cleft palate in mice is influenced by genes linked to H-2 and H-3.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fetal Resorption; Genotype; H-2 Antigens | 1983 |
Diphenylhydantoin: an alternative ligand of a glucocorticoid receptor affecting prostaglandin generation in A/J mice.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Binding, Competitive; Cleft Palate; Dexamethasone; Liver; Lun | 1982 |
[Anesthesia in an infant with fetal hydantoin syndrome].
Topics: Abnormalities, Drug-Induced; Anesthesia, Endotracheal; Cleft Lip; Cleft Palate; Humans; Infant; Male | 1982 |
Occurrence of cleft palate, micrognathia, and agnathia in selected strains of cortisone- and phenytoin-treated mice.
Topics: Animals; Cleft Palate; Cortisone; Female; Genes; H-2 Antigens; Jaw Abnormalities; Male; Mandible; Mi | 1982 |
The teratological problem of antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Adult; Animals; Anticonvulsants; Chromosome Aberrations; Cleft Lip; Cle | 1980 |
Maternal hyperoxia greatly reduces the incidence of phenytoin-induced cleft lip and palate in A/J mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Female; Mice; Mice, Inbred A; Oxygen; | 1981 |
Comparative teratogenicity of cortisone and phenytoin in mice.
Topics: Animals; Body Weight; Cleft Palate; Cortisone; Dose-Response Relationship, Drug; Female; Fetal Resor | 1981 |
Basilar invagination and mid-line skeletal abnormalities due to in utero exposure to phenytoin.
Topics: Adult; Arnold-Chiari Malformation; Bone Transplantation; Cleft Lip; Cleft Palate; Diseases in Twins; | 1994 |
Genome scan for teratogen-induced clefting susceptibility loci in the mouse: evidence of both allelic and locus heterogeneity distinguishing cleft lip and cleft palate.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Alleles; Animals; Chromosome Mapping; Cleft Lip; C | 1997 |
Diphenylhydantoin affects glycosaminoglycans and collagen production by human fibroblasts from cleft palate patients.
Topics: Cells, Cultured; Child; Child, Preschool; Chondroitin Sulfates; Cleft Palate; Collagen; Dermatan Sul | 1998 |
Temporal and spatial expression of Hoxa-2 during murine palatogenesis.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Anticonvulsants; Blotting, Northern; Blotting, W | 2000 |
Antioxidant and GSH-related enzyme response to a single teratogenic exposure to the anticonvulsant phenytoin: temporospatial evaluation.
Topics: Abortion, Veterinary; Animals; Anticonvulsants; Antioxidants; Catalase; Cleft Palate; Cytosol; Down- | 2000 |
Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bradycardia; Cleft Palate; Delayed Rectifier | 2001 |
Letter: Diazepam, phenytoin, and aetiology of cleft lip and/or cleft palate.
Topics: Anencephaly; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Infant, Newborn; Phenytoin; Pregnanc | 1976 |
Palate morphology and fetal movements in mice after DPH.
Topics: Animals; Cleft Palate; Fetus; Mice; Movement; Muscles; Palate; Phenytoin; Rotation | 1979 |
Epilepsy among parents of children with facial clefts.
Topics: Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Male; Parents; Phenobarbital; Ph | 1979 |
Phenytoin (dilantin)-induced cleft lip and palate in A/J mice: a scanning and transmission electron microscopic study.
Topics: Animals; Cleft Lip; Cleft Palate; Female; Lip; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; | 1979 |
Phenytoin and carbamazepine in production of cleft palates in mice. Comparison of teratogenic effects.
Topics: Animals; Carbamazepine; Cleft Palate; Dose-Response Relationship, Drug; Female; Mice; Phenytoin; Pre | 1979 |
Malignant mesenchymoma and birth defects. Prenatal exposure to phenytoin.
Topics: Adolescent; Adult; Cleft Lip; Cleft Palate; Epilepsy; Female; Follow-Up Studies; Humans; Male; Mater | 1977 |
A teratological evaluation of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anencephaly; Anticonvulsants; Cleft Lip; Cleft Palate; Diazepam; Epilep | 1977 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio | 1976 |
The effect of cortisone on the teratogenic action of acetylsalicylic acid and diphenylhydantoin in the mouse.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cleft Palate; Cortisone; Drug Administration Schedule | 1976 |
Teratogenic activity of the antiepileptic drugs phenobarbital, phenytoin, and primidone in mice.
Topics: Animals; Cleft Palate; Drug Interactions; Female; Gestational Age; Leucovorin; Maternal-Fetal Exchan | 1975 |
Teratogenicity of oral diazepam and diphenylhydantoin in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Diazepam; Female; Fetal Death; Fetu | 1975 |
[Are anticonvulsant agents teratogenic].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Humans; Infant, Newborn; Male | 1975 |
Congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord | 1975 |
Epilepsy anticonvulsants and malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1975 |
Embryotoxicity of phenytoin in adrenalectomized CD-1 mice.
Topics: Abnormalities, Drug-Induced; Adrenalectomy; Animals; Cleft Palate; Corticosterone; Female; Fetal Res | 1992 |
Major effects on teratogen-induced facial clefting in mice determined by a single genetic region.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Animals; Chromosomes; Cleft Lip; Cleft Palate; Gen | 1990 |
The relation between phenytoin-receptor and glucocorticoid in the induction of cleft palate with phenytoin in mice.
Topics: Abnormalities, Drug-Induced; Animals; Binding, Competitive; Cleft Palate; Cytosol; Female; Lung; Mic | 1989 |
[Comparison of the teratogenic properties manifested in BALB c mice, by diphenylhydantoin and deuterated diphenylhydantoin].
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Deuterium; Female; Mice; Mice, Inbred BALB C; Ph | 1989 |
Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cleft Palate; Dealkylation; Dimethadione; Dose-Respon | 1989 |
Modulation of embryonic glutathione reductase and phenytoin teratogenicity by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
Topics: Animals; Carmustine; Cleft Palate; Drug Interactions; Embryo, Mammalian; Female; Fetal Resorption; G | 1989 |
Enhancement of murine phenytoin teratogenicity by the gamma-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine and by the glutathione depletor diethyl maleate.
Topics: Administration, Oral; Analysis of Variance; Animals; Body Weight; Buthionine Sulfoximine; Cleft Pala | 1989 |
Inhibition of embryonic palatal shelf horizontalization and medial edge epithelial breakdown by cortisol: role of H-2 in the mouse.
Topics: Animals; Cleft Palate; Culture Techniques; Epithelium; H-2 Antigens; Hydrocortisone; Mice; Mice, Inb | 1988 |
Susceptibility to phenytoin-induced cleft lip with or without cleft palate: many genes are involved.
Topics: Animals; Cleft Lip; Cleft Palate; Disease Susceptibility; Mice; Mice, Inbred Strains; Phenytoin; Rec | 1987 |
Effect of route of administration on phenytoin teratogenicity in A/J mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Diet; Female; Fetal Resorption; Injec | 1986 |
Pharmacological studies on the potentiation of phenytoin teratogenicity by acetaminophen.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Brain; Cleft Palate; Drug Synergism; Embryo Los | 1986 |
Lack of maternal metabolic, endocrine, and environmental influences in the etiology of cleft lip with or without cleft palate.
Topics: Adult; Cleft Lip; Cleft Palate; Drug Interactions; Endocrine Glands; Erythrocytes; Female; Folic Aci | 1985 |
Genetic variation in spontaneous and diphenylhydantoin-induced craniofacial malformations in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Crosses, Genetic; Facial Bones; Female; Genetic | 1985 |
Potentiation of the teratogenic effects and altered disposition of diphenylhydantoin in mice fed a purified diet.
Topics: Analysis of Variance; Animals; Cleft Palate; Congenital Abnormalities; Diet; Female; Fetus; Hexobarb | 1985 |
Congenital malformations among infants born to epileptic women.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Congenital Abnormalities; England; Epilepsy; F | 1973 |
Ceft palate in the offspring of female mice treated with phenytoin.
Topics: Animals; Cleft Palate; Female; Mice; Phenytoin; Pregnancy | 1969 |
Do anticonvulsants have a teratogenic effect?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Cleft Palate; Congenital | 1974 |
The pattogenesis of submucous cleft palate.
Topics: Abnormalities, Drug-Induced; Animals; Cell Differentiation; Cleft Palate; Disease Models, Animal; Fe | 1974 |
Updating the genetics of cleft lip and palate.
Topics: Cleft Lip; Cleft Palate; Environmental Exposure; Face; Female; Humans; Male; Maternal Age; Nervous S | 1974 |
Further studies on effect of diphenylhydantoin sodium on oro-facial tissues in offspring of female mice.
Topics: Animals; Animals, Newborn; Cleft Palate; Dose-Response Relationship, Drug; Female; Hypertrophy; Mice | 1972 |
The modifying effect of folinic acid on diphenylhydantoin-induced teratogenicity in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fetal Death; Fetus; Leucovorin; Mice; Or | 1973 |
Editorial: Teratogenesis and antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Congenital Abnormalities; Epi | 1973 |
The teratological effects of anticonvulsants and the effects on pregnancy and birth.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cleft Lip; Cleft Palate; Cyclohe | 1973 |
Placental transfer and neonatal elimination of diphenylhydantoin.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Infant, Newborn; Lon | 1971 |
[Teratogenic effect of phenytoin].
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Infant, Newborn; Phe | 1972 |
Diphenylhydantoin teratogenicity in rats.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Cleft Palate; Female; Fetal Death | 1972 |
Effect of diphenylhydantoin on palatal closure in the rat embryo.
Topics: Abnormalities, Drug-Induced; Cleft Palate; Phenytoin | 1971 |
Relation of dosage and time of administration of diphenylhydantoin to its teratogenic effect in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Lip; Cleft Palate; Embryonic and Fetal Deve | 1969 |
[Congenital abnormalities, cleft lip and cleft palate in particular, in children of epileptic mothers].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Cleft Lip; Cleft Palate; Epilepsy; Fema | 1971 |
Teratogenic effects of diphenylhydantoin in Swiss-Webster and A-J mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Female; Femur; Fetus; Fibula; Humerus | 1968 |
Teratogenic effects of diphenylhydantoin sodium.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Female; Mice; Phenytoin; Pregnancy; P | 1966 |