phenytoin has been researched along with Chronic Kidney Failure in 52 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with chronic renal failure had low plasma total, but disproportionately high plasma free, drug concentrations indicating impaired protein binding." | 5.26 | Salivary phenytoin concentrations in epilepsy and in chronic renal failure. ( Jones, NF; Reynolds, F; Smith, SE; Ziroyanis, PN, 1976) |
| "In an exploratory study the 24-h urinary excretion pattern of caffeine and 14 of its major metabolites was studied in 32 volunteers (adults, adolescents and children), 14 patients either with end stage renal disease or liver cirrhosis, 7 heavy smokers and 27 patients on therapy with cimetidine, allopurinol, theophylline or phenytoin." | 3.68 | Urinary caffeine metabolites in man. Age-dependent changes and pattern in various clinical situations. ( Bircher, J; Brandes, A; Compagnone, D; Hille, H; Münch, B; Ullrich, D, 1992) |
| "The effect of chronic renal disease on the serum free fraction of phenytoin, diazepam and propranolol was examined in vitro among 60 conservatively treated patients with renal insufficiency of varying degree and different etiology, and in 10 patients with a nephrotic syndrome." | 3.67 | Serum protein binding of phenytoin, diazepam and propranolol in chronic renal diseases. ( Neuvonen, PJ; Tallgren, LG; Tiula, E, 1987) |
| "The pharmacokinetic behavior of fosphenytoin (FOS), the water-soluble prodrug of phenytoin (PHT), has been characterized in normal subjects." | 2.69 | Pharmacokinetics of fosphenytoin in patients with hepatic or renal disease. ( Alldredge, BK; Aweeka, FT; Boyer, TD; Eldon, MA; Gambertoglio, JG; Gottwald, MD; Kugler, AR; Pollock, AS; Wright, TL, 1999) |
| "Although an ESRD WT equation was historically proposed for this population, there is a lack of data evaluating its accuracy." | 1.46 | Characterization of Free Phenytoin Concentrations in End-Stage Renal Disease Using the Winter-Tozer Equation. ( Kane, SP; Soriano, VV; Tesoro, EP, 2017) |
| "Porphyria cutanea tarda is a disorder of heme biosynthesis resulting from a defect or deficiency in the enzyme uroporphyrinogen decarboxylase." | 1.29 | Porphyria cutanea tarda in a patient on chronic ambulatory peritoneal dialysis. ( Demento, FJ; Fishbane, S; Frei, GL; Maesaka, JK; Ruggian, JC, 1996) |
| "In 43 ICU patients undergoing continuous volume constant hemofiltration (CVHF), the pharmacokinetics of 12 drugs were investigated to ensure correct dosage adjustments." | 1.28 | [Dosage adjustment of drugs during continuous hemofiltration. Results and practical consequences of a prospective clinical study]. ( Dehne, M; el Abed, K; Hofmann, W; Kroh, U; Lennartz, H, 1989) |
| "When phenytoin was added in vitro to plasma from nonepileptic oliguric azotemic patients, the measured phenytoin values were close to and not higher than the target values by either methodology." | 1.26 | A comparison of plasma phenytoin level determinations by EMIT and gas-liquid chromatography in patients with renal insufficiency. ( Fairclough, GF; Kutt, H; Nandedkar, AK; Williamson, R, 1980) |
| "Patients with chronic renal failure had low plasma total, but disproportionately high plasma free, drug concentrations indicating impaired protein binding." | 1.26 | Salivary phenytoin concentrations in epilepsy and in chronic renal failure. ( Jones, NF; Reynolds, F; Smith, SE; Ziroyanis, PN, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (61.54) | 18.7374 |
| 1990's | 11 (21.15) | 18.2507 |
| 2000's | 4 (7.69) | 29.6817 |
| 2010's | 5 (9.62) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Soriano, VV | 1 |
| Tesoro, EP | 1 |
| Kane, SP | 1 |
| Khan, AM | 1 |
| Marvanova, M | 1 |
| Bezzaoucha, S | 1 |
| Merghoub, A | 1 |
| Lamarche, C | 1 |
| Pichette, V | 1 |
| Lafrance, JP | 1 |
| Laurin, LP | 2 |
| Vallée, M | 1 |
| Robitaille, R | 1 |
| Leblanc, M | 1 |
| Bell, R | 1 |
| Zappia, CP | 1 |
| Piccirillo, B | 1 |
| Lévesque, R | 1 |
| Roy, L | 1 |
| Sen, S | 1 |
| Ratnaraj, N | 1 |
| Davies, NA | 1 |
| Mookerjee, RP | 1 |
| Cooper, CE | 1 |
| Patsalos, PN | 1 |
| Williams, R | 1 |
| Jalan, R | 1 |
| Roberts, WL | 2 |
| Rainey, PM | 1 |
| McBryde, KD | 1 |
| Wilcox, J | 1 |
| Kher, KK | 1 |
| Liponi, DF | 1 |
| Winter, ME | 1 |
| Tozer, TN | 1 |
| Hirai, M | 1 |
| Yoshioka, K | 1 |
| Imada, A | 1 |
| McDonald, DM | 1 |
| Kabra, PM | 1 |
| Nandedkar, AK | 1 |
| Williamson, R | 1 |
| Kutt, H | 2 |
| Fairclough, GF | 1 |
| Depner, TA | 1 |
| Stanfel, LA | 1 |
| Jarrard, EA | 1 |
| Gulyassy, PF | 1 |
| Kinniburgh, DW | 1 |
| Boyd, ND | 1 |
| Profeta, LM | 1 |
| Bradbury, K | 1 |
| Mehl, B | 1 |
| Szenohradszky, J | 1 |
| Caldwell, JE | 1 |
| Sharma, ML | 1 |
| Gruenke, LD | 1 |
| Miller, RD | 1 |
| Ruggian, JC | 1 |
| Fishbane, S | 1 |
| Demento, FJ | 1 |
| Maesaka, JK | 1 |
| Frei, GL | 1 |
| Bissoli, F | 1 |
| Gini, G | 1 |
| Bosio, M | 1 |
| Ceriani, R | 1 |
| Fung, SM | 1 |
| Ferrill, MJ | 1 |
| Norton, LL | 1 |
| Frenchie, D | 1 |
| Bastani, B | 1 |
| De, BK | 1 |
| Coleman, JP | 1 |
| Annesley, TM | 1 |
| Aweeka, FT | 1 |
| Gottwald, MD | 1 |
| Gambertoglio, JG | 1 |
| Wright, TL | 1 |
| Boyer, TD | 1 |
| Pollock, AS | 1 |
| Eldon, MA | 1 |
| Kugler, AR | 1 |
| Alldredge, BK | 1 |
| Hodges, CB | 1 |
| Maxwell, H | 1 |
| Beattie, TJ | 1 |
| Murphy, AV | 1 |
| Jindal, RM | 1 |
| Kaspar, U | 1 |
| Rullière, R | 1 |
| Vial, F | 1 |
| Chastre, J | 1 |
| Schmitt, H | 1 |
| Reynolds, F | 1 |
| Ziroyanis, PN | 1 |
| Jones, NF | 1 |
| Smith, SE | 1 |
| Poser, W | 1 |
| Poser, S | 1 |
| Ritter, G | 1 |
| Steele, WH | 1 |
| Lawrence, JR | 1 |
| Elliott, HL | 1 |
| Whiting, B | 1 |
| Trebbin, WM | 1 |
| Borgå, O | 2 |
| Hoppel, C | 1 |
| Odar-Cederlöf, I | 2 |
| Garle, M | 1 |
| van Peer, AP | 1 |
| Belpaire, FM | 1 |
| Bogaert, MG | 1 |
| Kremer, GJ | 1 |
| Atzpodien, W | 1 |
| Gibaldi, M | 1 |
| Olsen, GD | 1 |
| Bennett, WM | 1 |
| Porter, GA | 1 |
| Sungur, C | 1 |
| Sungur, A | 1 |
| Akpolat, T | 1 |
| Yasavul, U | 1 |
| Turgan, C | 1 |
| Caglar, S | 1 |
| Ullrich, D | 1 |
| Compagnone, D | 1 |
| Münch, B | 1 |
| Brandes, A | 1 |
| Hille, H | 1 |
| Bircher, J | 1 |
| Kaplan, B | 1 |
| Krumlovsky, FA | 1 |
| Kroh, U | 1 |
| Hofmann, W | 1 |
| Dehne, M | 1 |
| el Abed, K | 1 |
| Lennartz, H | 1 |
| Mauro, LS | 1 |
| Mauro, VF | 1 |
| Bachmann, KA | 1 |
| Higgins, JT | 1 |
| Doherty, JE | 1 |
| Sedman, AJ | 1 |
| Molitoris, BA | 1 |
| Nakata, LM | 1 |
| Gal, J | 1 |
| Vanholder, R | 1 |
| Van Landschoot, N | 1 |
| De Smet, R | 1 |
| Schoots, A | 1 |
| Ringoir, S | 1 |
| Tiula, E | 1 |
| Tallgren, LG | 1 |
| Neuvonen, PJ | 1 |
| Brown-Molnar, CS | 1 |
| Bauer, LA | 1 |
| Horn, JR | 1 |
| Fabre, J | 1 |
| Balant, L | 1 |
| Chavaz, A | 1 |
| Verma, IC | 1 |
| Khanna, AR | 1 |
| Rahn, KH | 1 |
| Cohen, H | 1 |
| Langendorf, R | 1 |
| Pick, A | 1 |
| Djonlagić, H | 1 |
| von Kurnatowski, HA | 1 |
| Diederich, KW | 1 |
| Desjacques, P | 1 |
| Letteri, JM | 1 |
| Mellk, H | 1 |
| Louis, S | 1 |
| Durante, P | 1 |
| Glazko, A | 1 |
6 reviews available for phenytoin and Chronic Kidney Failure
| Article | Year |
|---|---|
Fish oil therapy in IgA nephropathy.
Topics: Anticonvulsants; Clinical Trials as Topic; Fish Oils; Glomerulonephritis, IGA; Humans; Kidney Failur | 1997 |
[Diphenylhydantoin. Metabolism, pharmacokinetics, interactions and side effects].
Topics: Anti-Anxiety Agents; Benzodiazepines; Bone and Bones; Bone Marrow; Carbamazepine; Cerebellar Disease | 1976 |
[Digitalis poisoning and the risk of associated treatment].
Topics: Acid-Base Imbalance; Aged; Atropine; Cardiac Complexes, Premature; Digitalis Glycosides; Digitoxin; | 1976 |
Clinical use of digitalis glycosides. An update.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Age Factors; Anti-Arrhythmia Agents; Antihyperten | 1985 |
Vitamin D and rickets.
Topics: Acidosis, Renal Tubular; Animals; Bone and Bones; Bone Neoplasms; Calcification, Physiologic; Dihydr | 1973 |
[Pharmacotherapy in chronic kidney failure].
Topics: Anti-Bacterial Agents; Antihypertensive Agents; Cardiac Glycosides; Clofibrate; Digitoxin; Digoxin; | 1974 |
1 trial available for phenytoin and Chronic Kidney Failure
| Article | Year |
|---|---|
Pharmacokinetics of fosphenytoin in patients with hepatic or renal disease.
Topics: Adult; Anticonvulsants; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Kidney | 1999 |
45 other studies available for phenytoin and Chronic Kidney Failure
| Article | Year |
|---|---|
Characterization of Free Phenytoin Concentrations in End-Stage Renal Disease Using the Winter-Tozer Equation.
Topics: Adult; Albumins; Anticonvulsants; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Models | 2017 |
Prediction Accuracy of Winter-Tozer Equations to Estimate Free Phenytoin Concentrations in Non-Critically Ill Hospitalized Patients.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Black or African American; Female; Hospitalization; | 2017 |
Hemodialysis effects on phenytoin pharmacokinetics.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Kidney Failure, Chronic; Male; Phenytoin; Renal Dialysis | 2014 |
Ataxia and dizziness in a patient on hemodialysis.
Topics: Anticonvulsants; Ataxia; Dizziness; Humans; Kidney Failure, Chronic; Male; Middle Aged; Phenytoin; R | 2014 |
Hemodiafiltration does not improve drug protein binding compared to conventional hemodialysis: an in vitro study.
Topics: Anticonvulsants; Antimalarials; Hemodiafiltration; Humans; Kidney Failure, Chronic; Phenytoin; Prote | 2012 |
Treatment of phenytoin toxicity by the molecular adsorbents recirculating system (MARS).
Topics: Anticonvulsants; Drug Overdose; Equipment Design; Hemofiltration; Humans; Kidney Failure, Chronic; L | 2003 |
Phenytoin overview--metabolite interference in some immunoassays could be clinically important.
Topics: Cross Reactions; Humans; Immunoassay; Kidney Failure, Chronic; Phenytoin | 2004 |
Hyperphosphatemia due to fosphenytoin in a pediatric ESRD patient.
Topics: Adolescent; Anticonvulsants; Epilepsy, Complex Partial; Humans; Kidney Failure, Chronic; Male; Pheny | 2005 |
Renal function and therapeutic concentrations of phenytoin.
Topics: Adult; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Phenytoin; Serum Albumin | 1984 |
[Blood levels of anticonvulsants during hemodialysis].
Topics: Anticonvulsants; Child; Child, Preschool; Female; Humans; Kidney Failure, Chronic; Male; Phenobarbit | 1983 |
Renal disease may increase apparent phenytoin in serum as measured by enzyme-multiplied immunoassay.
Topics: Adult; Female; Humans; Immunoenzyme Techniques; Kidney Failure, Chronic; Phenytoin | 1980 |
A comparison of plasma phenytoin level determinations by EMIT and gas-liquid chromatography in patients with renal insufficiency.
Topics: Chromatography, Gas; Cross Reactions; Humans; Immunoenzyme Techniques; Kidney Failure, Chronic; Phen | 1980 |
Impaired plasma phenytoin binding in uremia. Effect of in vitro acidification and anion-exchange resin.
Topics: Albumins; Anion Exchange Resins; Binding, Competitive; Humans; Hydrogen-Ion Concentration; Kidney Fa | 1980 |
Phenytoin binding to partially purified albumin in renal disease.
Topics: Humans; Kidney Failure, Chronic; Kinetics; Phenytoin; Protein Binding; Serum Albumin | 1981 |
Pharmacokinetic considerations in phenytoin pharmacotherapy: preventing overdoses and underdoses.
Topics: Acute Kidney Injury; Anticonvulsants; Humans; Kidney Failure, Chronic; Monitoring, Physiologic; Phen | 1995 |
Interaction of rocuronium (ORG 9426) and phenytoin in a patient undergoing cadaver renal transplantation: a possible pharmacokinetic mechanism?
Topics: Adult; Androstanols; Cadaver; Drug Interactions; Epilepsy, Tonic-Clonic; Humans; Kidney Failure, Chr | 1994 |
Porphyria cutanea tarda in a patient on chronic ambulatory peritoneal dialysis.
Topics: Adult; Anticonvulsants; Carbamazepine; Humans; Kidney Failure, Chronic; Male; Peritoneal Dialysis, C | 1996 |
Concurrent use of phenytoin and furosemide: problems in a patient with congestive cardiac failure, chronic renal failure, liver cirrhosis and fluid overload.
Topics: Anticonvulsants; Diuretics; Drug Interactions; Drug Therapy, Combination; Furosemide; Heart Failure; | 1996 |
Significant removal of phenytoin during high flux dialysis with cellulose triacetate dialyzer.
Topics: Anticonvulsants; Cellulose; Humans; Kidney Failure, Chronic; Phenytoin; Renal Dialysis | 1998 |
Falsely increased immunoassay measurements of total and unbound phenytoin in critically ill uremic patients receiving fosphenytoin.
Topics: Acute Kidney Injury; Anticonvulsants; Chromatography, High Pressure Liquid; Critical Illness; Cross | 1999 |
Use of rapamycin in a transplant patient who developed cyclosporin neurotoxicity.
Topics: Anticonvulsants; Child; Cyclosporine; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Graf | 2001 |
Salivary phenytoin concentrations in epilepsy and in chronic renal failure.
Topics: Adolescent; Adult; Biological Availability; Child; Child, Preschool; Epilepsy; Female; Humans; Kidne | 1976 |
[Drug therapy of epilepsy].
Topics: Age Factors; Anticonvulsants; Barbiturates; Benzodiazepines; Bromides; Carbamazepine; Chlormethiazol | 1977 |
Alterations of phenytoin protein binding with in vivo haemodialysis in dialysis encephalopathy.
Topics: Adult; Binding Sites; Blood Proteins; Brain Diseases; Humans; Kidney Failure, Chronic; Kinetics; Mal | 1979 |
Hemodialysis and pregnancy.
Topics: Acute Kidney Injury; Adolescent; Adult; Chloral Hydrate; Female; Glutethimide; Humans; Infant, Newbo | 1979 |
Plasma levels and renal excretion of phenytoin and its metabolites in patients with renal failure.
Topics: Adult; Aged; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Phenytoin | 1979 |
In vitro hepatic oxidative metabolism of antipyrine, phenytoin and phenylbutazone in rabbits with experimental renal failure.
Topics: Animals; Antipyrine; In Vitro Techniques; Kidney Failure, Chronic; Kinetics; Liver; Oxidation-Reduct | 1978 |
[Fabry's diffuse angiokeratoma corporis].
Topics: Age Factors; Carbamazepine; Fabry Disease; Galactosidases; Glycolipids; Heterozygote; Humans; Kidney | 1975 |
Drug distribution in renal failure.
Topics: Antipyrine; Clofibrate; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Kidney Failure, Ch | 1977 |
Lack of relationship between serum free fatty acids and impaired plasma protein binding of diphenylhydantoin in chronic renal failure.
Topics: Adult; Aged; Blood Proteins; Cholesterol; Creatinine; Fatty Acids, Nonesterified; Female; Humans; Ki | 1976 |
Morphine and phenytoin binding to plasma proteins in renal and hepatic failure.
Topics: Bilirubin; Blood Proteins; Creatinine; Humans; Jaundice; Kidney Failure, Chronic; Kidney Transplanta | 1975 |
Unresponsiveness to human recombinant erythropoietin in an epileptic dialysis patient secondary to valproic acid toxicity.
Topics: Adult; Electrocardiography; Epilepsy, Tonic-Clonic; Erythropoietin; Female; Humans; Kidney Failure, | 1992 |
Urinary caffeine metabolites in man. Age-dependent changes and pattern in various clinical situations.
Topics: Adolescent; Adult; Age Factors; Allopurinol; Caffeine; Child; Cimetidine; Drug Interactions; Female; | 1992 |
Phenytoin in end-stage renal disease.
Topics: Humans; Kidney Failure, Chronic; Phenytoin; Protein Binding | 1992 |
[Dosage adjustment of drugs during continuous hemofiltration. Results and practical consequences of a prospective clinical study].
Topics: Adult; Aged; Cefotaxime; Ceftazidime; Digitoxin; Digoxin; Hemofiltration; Humans; Imipenem; Kidney F | 1989 |
Accuracy of two equations in determining normalized phenytoin concentrations.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Hypoproteinemia; Kidney Failure, Chronic; Male; Math | 1989 |
Therapeutic drug monitoring in patients with chronic renal failure: evaluation of the Abbott TDx drug assay system.
Topics: Carbamazepine; Cross Reactions; Digoxin; Gentamicins; Humans; Immunoassay; Kidney Failure, Chronic; | 1986 |
Drug protein binding in chronic renal failure: evaluation of nine drugs.
Topics: Blood Proteins; Chromatography, High Pressure Liquid; Humans; Kidney Failure, Chronic; Pharmaceutica | 1988 |
Serum protein binding of phenytoin, diazepam and propranolol in chronic renal diseases.
Topics: Creatinine; Diazepam; Humans; Kidney Failure, Chronic; Nephrotic Syndrome; Orosomucoid; Phenytoin; P | 1987 |
Phenytoin removal by plasmapheresis in renal insufficiency.
Topics: Adult; Female; Humans; Kidney Failure, Chronic; Kinetics; Lupus Erythematosus, Systemic; Phenytoin; | 1986 |
Recent drug management advances in renal insufficiency.
Topics: Body Fluids; Carrier Proteins; Glomerular Filtration Rate; Humans; Hypoproteinemia; Kidney; Kidney F | 1974 |
Intermittent parasystole--mechanism of protection.
Topics: Aged; Aminosalicylic Acids; Arrhythmias, Cardiac; Arteriosclerosis; Cerebrovascular Disorders; Coron | 1973 |
[Bidirectional tachycardia caused by digitalis (author's transl)].
Topics: Administration, Oral; Coronary Disease; Digoxin; Electrocardiography; Female; Heart Failure; Humans; | 1974 |
[The diffusion of diphenylhydantoin across the cellophane membrane of the artificial kidney in a patient with uremia and epilepsy].
Topics: Cellophane; Diffusion; Epilepsy; Humans; Kidney Diseases, Cystic; Kidney Failure, Chronic; Kidneys, | 1972 |
Diphenylhydantoin metabolism in uremia.
Topics: Administration, Oral; Adult; Female; Humans; Injections, Intravenous; Kidney Failure, Chronic; Male; | 1971 |