Page last updated: 2024-10-21

phenytoin and Chronic Illness

phenytoin has been researched along with Chronic Illness in 81 studies

Research Excerpts

ExcerptRelevanceReference
"To compare topical diphenylhydantoin (phenytoin) with Edinburgh University solution of lime (EUSOL) in terms of rate of ulcer healing, analgesic and antibacterial properties in non-malignant chronic leg ulcers."9.10Topical phenytoin versus EUSOL in the treatment of non-malignant chronic leg ulcers. ( Carneiro, PM; Nyawawa, ET, 2003)
"In view of the reports that phenytoin and honey are useful in the healing of wounds, a comparison of their topical use in the treatment of chronic leg ulcers was carried out."9.09A comparison of topical honey and phenytoin in the treatment of chronic leg ulcers. ( Olabanji, JK; Oluwatosin, OA; Oluwatosin, OM; Onyechi, HU; Tijani, LA, 2000)
"Women with a singleton pregnancy in vertex presentation between 32 and 42 weeks' gestation who required induction of labor for either preeclampsia, preeclampsia superimposed on chronic hypertension, or transient hypertension were randomized to receive either magnesium sulfate or phenytoin (Dilantin) for seizure prophylaxis."9.08Does magnesium sulfate affect the length of labor induction in women with pregnancy-associated hypertension? ( Atkinson, MW; Guinn, D; Hauth, JC; Owen, J, 1995)
"The wound healing effects of topical phenytoin powder were compared with those of normal saline in a controlled in-patient study of 100 patients with 110 trophic leprosy ulcers of varying chronicity, over a 4-week study period."9.07Comparison of topical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy. ( Bansal, NK, 1993)
"The purpose of this study was to assess the possible role of the (R)- and (S)- enantiomers of the phenytoin metabolite p-HPPH in the pathogenesis of gingival hyperplasia (GH)."7.69Effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic-gingival hyperplasia: in vivo and in vitro study. ( Goto, W; Higuchi, S; Hirata, K; Ieiri, I; Imayama, S; Ohtsubo, K; Ohyama, Y; Toshitani, A; Yamada, H, 1995)
" The anti-convulsant drug phenytoin predisposes to gingival hyperplasia in certain patients who take this medication for epilepsy and who also have poor oral hygiene."7.68Langerhans cells in human chronic gingivitis and phenytoin-induced gingival hyperplasia. ( Chisholm, DM; Drummond, JR; Kinane, DF, 1990)
"Reversible chronic cerebellar ataxia followed phenytoin treatment in two epileptic women."7.67Reversible chronic cerebellar ataxia after phenytoin intoxication: possible role of cerebellum in cognitive thought. ( Attig, E; Botez, MI; Gravel, J; Vézina, JL, 1985)
"Phenobarbital and MK-801 were superior to phenytoin in suppressing SE and in preventing chronic epilepsy."5.31Phenobarbital and MK-801, but not phenytoin, improve the long-term outcome of status epilepticus. ( Bertram, EH; Prasad, A; Williamson, JM, 2002)
"AVO cream significantly accelerates biological healing of chronic wounds and helps to reduce pain severity with a higher efficacy compared with phenytoin cream."5.20Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds. ( Beiraghdar, F; Izadi, M; Jonaidi-Jafari, N; Panahi, Y; Rezaee, R; Sahebkar, A; Sayyadi, N; Zamani, A, 2015)
"To compare topical diphenylhydantoin (phenytoin) with Edinburgh University solution of lime (EUSOL) in terms of rate of ulcer healing, analgesic and antibacterial properties in non-malignant chronic leg ulcers."5.10Topical phenytoin versus EUSOL in the treatment of non-malignant chronic leg ulcers. ( Carneiro, PM; Nyawawa, ET, 2003)
"In view of the reports that phenytoin and honey are useful in the healing of wounds, a comparison of their topical use in the treatment of chronic leg ulcers was carried out."5.09A comparison of topical honey and phenytoin in the treatment of chronic leg ulcers. ( Olabanji, JK; Oluwatosin, OA; Oluwatosin, OM; Onyechi, HU; Tijani, LA, 2000)
"Women with a singleton pregnancy in vertex presentation between 32 and 42 weeks' gestation who required induction of labor for either preeclampsia, preeclampsia superimposed on chronic hypertension, or transient hypertension were randomized to receive either magnesium sulfate or phenytoin (Dilantin) for seizure prophylaxis."5.08Does magnesium sulfate affect the length of labor induction in women with pregnancy-associated hypertension? ( Atkinson, MW; Guinn, D; Hauth, JC; Owen, J, 1995)
"The wound healing effects of topical phenytoin powder were compared with those of normal saline in a controlled in-patient study of 100 patients with 110 trophic leprosy ulcers of varying chronicity, over a 4-week study period."5.07Comparison of topical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy. ( Bansal, NK, 1993)
"Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action."3.70Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain. ( Alves, ND; de Carvalho, AM; de Castro-Costa, CM; Santos, FJ; Silveira, DG, 1999)
"The purpose of this study was to assess the possible role of the (R)- and (S)- enantiomers of the phenytoin metabolite p-HPPH in the pathogenesis of gingival hyperplasia (GH)."3.69Effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic-gingival hyperplasia: in vivo and in vitro study. ( Goto, W; Higuchi, S; Hirata, K; Ieiri, I; Imayama, S; Ohtsubo, K; Ohyama, Y; Toshitani, A; Yamada, H, 1995)
"We report the case of a young man suffering from epilepsy who developed chronic calcified pancreatitis after ten years of therapy with the anticonvulsant drugs carbamazepine and phenytoin."3.68Anticonvulsant-induced chronic pancreatitis. A case report. ( Billi, P; Broccoli, PL; Fontana, G; Melandri, R; Pezzilli, R, 1992)
" The anti-convulsant drug phenytoin predisposes to gingival hyperplasia in certain patients who take this medication for epilepsy and who also have poor oral hygiene."3.68Langerhans cells in human chronic gingivitis and phenytoin-induced gingival hyperplasia. ( Chisholm, DM; Drummond, JR; Kinane, DF, 1990)
"Reversible chronic cerebellar ataxia followed phenytoin treatment in two epileptic women."3.67Reversible chronic cerebellar ataxia after phenytoin intoxication: possible role of cerebellum in cognitive thought. ( Attig, E; Botez, MI; Gravel, J; Vézina, JL, 1985)
"Focal electrographic seizures in this model are resistant to several major antiepileptic drugs."1.42The AMPA receptor antagonist NBQX exerts anti-seizure but not antiepileptogenic effects in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy. ( Bankstahl, M; Klein, S; Löscher, W; Römermann, K; Twele, F, 2015)
"Zinc oxide paste per se was not effective, but its role as a vehicle was an asset."1.40Trophic skin ulceration in leprosy: evaluation of the efficacy of topical phenytoin sodium zinc oxide paste. ( Kaviarasan, PK; Prasad, PV; Rajan, D; Sehgal, VN, 2014)
"Carbamazepine was the most common prescribed drug (76."1.38Trigeminal neuralgia: a retrospective study of 188 Thai cases. ( Aneksuk, V; Jainkittivong, A; Langlais, RP, 2012)
"Epileptic seizures drive expression of the blood-brain barrier efflux transporter P-glycoprotein via a glutamate/cyclooxygenase-2 mediated signalling pathway."1.36COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats. ( Aronica, E; Edelbroek, PM; Gorter, JA; Holtman, L; Pekcec, A; Potschka, H; Schlichtiger, J; van Vliet, EA; Zibell, G, 2010)
"We have observed acute dystonias in the absence of antipsychotic treatment and in the context of seizure activity (or paroxysmal dyskinetic activity)."1.33High vulnerability to acute dystonic reactions: a case of antipsychotic exposure and uncontrolled seizure activity. ( Botts, SR; Coffey, GL; de Leon, J, 2005)
"Phenobarbital and MK-801 were superior to phenytoin in suppressing SE and in preventing chronic epilepsy."1.31Phenobarbital and MK-801, but not phenytoin, improve the long-term outcome of status epilepticus. ( Bertram, EH; Prasad, A; Williamson, JM, 2002)
"Primary trigeminal neuralgia (tic douloureux) is characterized by severe paroxysms of pain often initiated by stimuli applied to trigger zones."1.27Benign chronic orofacial pain. Clinical criteria and therapeutic approaches. ( Dworkin, SF, 1983)
"Fifty-nine patients with chronic generalized tonic-clonic or partial seizures refractory to the maximally tolerated daily dosage of single-drug therapy with carbamazepine, phenytoin, phenobarbital, or primidone subsequently received single-drug therapy with another one of these primary anticonvulsant drugs."1.27Alternative single anticonvulsant drug therapy for refractory epilepsy. ( Richter, K; Schmidt, D, 1986)
"The effect of chronic administration of diphenylhydantoin on the fine structures of the rat cerebellum was ultrastructurally investigated."1.26Neurobiological studies of experimental diphenylhydantoin intoxication. - I. Electron microscopic investigations of the rat cerebellum with chronic diphenylhydantoin intoxication. ( Takeichi, M, 1981)
"Phenytoin dosage was increased to study the effect on the frequency of seizures and the serum concentrations of phenytoin and phenobarbitone."1.26Therapeutic and pharmacokinetic effects of increasing phenytoin in chronic epileptics on multiple drug therapy. ( Johnson, RH; Lambie, DG; Nanda, RN; Shakir, RA, 1976)
" (3) Use of well-standardized, yet simplified, mental performance tests in combination with changes in the dosage of medication can help in reaching a compromise between acceptable seizure control and avoidance of excessive slowing of mental activity."1.25Effects of different dosages of anticonvulsant drugs on mental performance in patients with chronic epilepsy. ( Dekaban, AS; Lehman, EJ, 1975)
" Unit dose packaging is used because the oral solid dosage forms (including placebos) are made to look alike."1.25Drug use and distribution in a pain rehabilitation center. ( Beckner, TF; Idsvoog, P, 1975)

Research

Studies (81)

TimeframeStudies, this research(%)All Research%
pre-199049 (60.49)18.7374
1990's12 (14.81)18.2507
2000's12 (14.81)29.6817
2010's8 (9.88)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sehgal, VN1
Prasad, PV1
Kaviarasan, PK1
Rajan, D1
Twele, F1
Bankstahl, M1
Klein, S1
Römermann, K1
Löscher, W1
Panahi, Y1
Izadi, M1
Sayyadi, N1
Rezaee, R1
Jonaidi-Jafari, N1
Beiraghdar, F1
Zamani, A1
Sahebkar, A1
Fang, Z1
Chen, S1
Qin, J1
Chen, B1
Ni, G1
Chen, Z1
Zhou, J1
Li, Z1
Ning, Y1
Wu, C1
Zhou, L1
van Vliet, EA3
Zibell, G1
Pekcec, A1
Schlichtiger, J1
Edelbroek, PM3
Holtman, L1
Aronica, E2
Gorter, JA3
Potschka, H1
Hokkam, E1
El-Labban, G1
Shams, M1
Rifaat, S1
El-Mezaien, M1
Jainkittivong, A1
Aneksuk, V1
Langlais, RP1
Blanco-Vidal, MJ1
Catalan-Urribarrena, G1
Lopez, JI1
del Aguila, C1
Magnet, A1
Pomposo-Gaztelu, I1
Montejo, M1
Carneiro, PM1
Nyawawa, ET1
Amin, A1
Casey, AT1
Etherington, G1
Coffey, GL1
Botts, SR1
de Leon, J1
Hui, Z1
Guang-Yu, M1
Chong-Tao, X1
Quan, Y1
Xiao-Hu, X1
Walker, M1
Redeker, S1
Studen-Pavlovich, D1
Ranalli, DN1
Black, JA1
Liu, S1
Hains, BC1
Saab, CY1
Waxman, SG1
Schaub, C1
Uebachs, M1
Beck, H1
van Schaik, R1
da Silva, FH1
Wadman, WJ1
Zipes, DP1
Orgain, ES1
Ferlic, RM1
Sellers, RD1
Lillehei, CW1
Eliot, RS1
Dostert, P1
Benedetti, MS1
Garson, A1
Gillette, PC1
Johnson, JP1
Swerdlow, M1
Cundill, JG1
Dworkin, SF1
Tashiro, N1
Takeichi, M2
Matsushima, M1
Kono, R1
Ando, S1
Mizushima, S1
Baraczka, K1
Molnár, G1
Atkinson, MW1
Guinn, D1
Owen, J1
Hauth, JC1
Guerreiro, CA1
Ramos, MC1
Annes, M1
Bansal, NK1
Pendse, AK1
Sharma, A1
Sodani, A1
Hada, S1
Ieiri, I2
Goto, W2
Hirata, K2
Toshitani, A2
Imayama, S2
Ohyama, Y2
Yamada, H2
Ohtsubo, K2
Higuchi, S2
Holt, P1
Alves, ND1
de Castro-Costa, CM1
de Carvalho, AM1
Santos, FJ1
Silveira, DG1
Oluwatosin, OM1
Olabanji, JK1
Oluwatosin, OA1
Tijani, LA1
Onyechi, HU1
Prasad, A1
Williamson, JM1
Bertram, EH1
Lambie, DG2
Johnson, RH2
Nanda, RN2
Shakir, RA2
Penin, H1
Jones, JH1
Meistrup-Larsen, KI1
Hermann, S1
Permin, H1
Weisman, Y1
Fattal, A1
Eisenberg, Z1
Harel, S1
Spirer, Z1
Harell, A1
Dekaban, AS1
Lehman, EJ1
Levine, MI1
Beckner, TF1
Idsvoog, P1
Fong, GR1
Vajda, FJ1
Merory, J1
Bladin, PF1
Affrime, M1
Reidenberg, MM1
Pezzilli, R1
Billi, P1
Melandri, R1
Broccoli, PL1
Fontana, G1
Berrocal, A1
Barón, JM1
Artal, A1
Feliu, J1
Ricart, C1
Higes, F1
Mallada, J1
Kinane, DF1
Drummond, JR1
Chisholm, DM1
Fredericks, CA1
Giannotta, SL1
Sadun, AA1
Beech, J1
Fletcher, JE1
Lizzo, F1
Johnston, J1
Miller, WI1
Schmidt, D1
Richter, K1
Botez, MI1
Gravel, J1
Attig, E1
Vézina, JL1
Glötzner, FL1
Friedman, AP1
Robins, AH1
Sharpe, JA1
Kones, RJ1
Phillips, JH1
Hersh, J1
Simopoulos, AM1
Pinto, A1
Uhlenhuth, EH1
McGee, JJ1
DeRosa, ER1
Haghshenass, M1
Rao, DB1
Sharp, HL1
Mirkin, BL1
Love, DW1
Salter, FJ1
Porciello, PI1
Zanini, S1
Poppi, A1
Matsuyama, Y1
Nakagawa, M1
Leary, PM1
Francis, J1
Stone, N1
Klein, MD1
Lown, B1
Booker, HE1
Tormey, A1
Toussaint, J1
Floris, N1
Dam, M1
Dimich, I1
Steinfeld, L1
Richman, R1
Lasser, R1
Gillen, HW1
Pippinger, CE1
Kaufmann, G1
Hauser, K1
Höglmeier, H1
Wenzel, U1
Kobayashi, K1
Takamizawa, M1
Kobayashi, T1
Otaka, T1
Fukuzawa, H1

Reviews

3 reviews available for phenytoin and Chronic Illness

ArticleYear
Status epilepticus: an evidence based guide.
    BMJ (Clinical research ed.), 2005, Sep-24, Volume: 331, Issue:7518

    Topics: Anticonvulsants; Chronic Disease; Critical Care; Drug Administration Routes; Emergency Treatment; Ev

2005
[Biochemical mechanisms of the hepatotoxicity of psychotropic drugs].
    L'Encephale, 1984, Volume: 10, Issue:5

    Topics: Acute Disease; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents, Tricyclic; Antipsychotic

1984
[Long-term anticonvulsant therapy (author's transl)].
    Der Nervenarzt, 1978, Volume: 49, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Clonazepam; Epilepsy; Ethosuximide; Humans; Long-Te

1978

Trials

10 trials available for phenytoin and Chronic Illness

ArticleYear
Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds.
    Journal of wound care, 2015, Volume: 24, Issue:10

    Topics: Aloe; Anti-Infective Agents; Chronic Disease; Double-Blind Method; Drug Therapy, Combination; Humans

2015
The use of topical phenytoin for healing of chronic venous ulcerations.
    International journal of surgery (London, England), 2011, Volume: 9, Issue:4

    Topics: Administration, Cutaneous; Adult; Chronic Disease; Dermatologic Agents; Drug Administration Schedule

2011
Topical phenytoin versus EUSOL in the treatment of non-malignant chronic leg ulcers.
    East African medical journal, 2003, Volume: 80, Issue:3

    Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Borates; Chronic Disease; Colony Count, Micro

2003
Does magnesium sulfate affect the length of labor induction in women with pregnancy-associated hypertension?
    American journal of obstetrics and gynecology, 1995, Volume: 173, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Cesarean Section; Chi-Square Distribution; Chronic Disease; Fema

1995
Comparison of topical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy.
    International journal of dermatology, 1993, Volume: 32, Issue:3

    Topics: Administration, Topical; Adult; Chronic Disease; Female; Humans; Leprosy; Male; Middle Aged; Phenyto

1993
Topical phenytoin in wound healing.
    International journal of dermatology, 1993, Volume: 32, Issue:3

    Topics: Administration, Topical; Adult; Chronic Disease; Female; Humans; Male; Phenytoin; Skin Ulcer; Wound

1993
The effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic side effects: in vivo and in vitro studies.
    Psychiatry and clinical neurosciences, 1995, Volume: 49, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Cell Division; Chronic Disease; DNA; Female; Fibroblasts;

1995
A comparison of topical honey and phenytoin in the treatment of chronic leg ulcers.
    African journal of medicine and medical sciences, 2000, Volume: 29, Issue:1

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Child; Chronic Disease; Drug

2000
Diphenylhydantoin effectiveness in the treatment of chronic schizophrenics. A double-blind controlled study with a placebo.
    Archives of general psychiatry, 1974, Volume: 30, Issue:1

    Topics: Administration, Oral; Adult; Chronic Disease; Clinical Trials as Topic; Dose-Response Relationship,

1974
Effect of phenobarbital on hyperbilirubinemia, bile acid metabolism, and microsomal enzyme activity in chronic intrahepatic cholestasis of childhood.
    The Journal of pediatrics, 1972, Volume: 81, Issue:1

    Topics: Bile; Bile Acids and Salts; Bilirubin; Biopsy; Child; Child, Preschool; Cholestasis; Chronic Disease

1972

Other Studies

68 other studies available for phenytoin and Chronic Illness

ArticleYear
Trophic skin ulceration in leprosy: evaluation of the efficacy of topical phenytoin sodium zinc oxide paste.
    International journal of dermatology, 2014, Volume: 53, Issue:7

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Bacterial Lo

2014
The AMPA receptor antagonist NBQX exerts anti-seizure but not antiepileptogenic effects in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy.
    Neuropharmacology, 2015, Volume: 95

    Topics: Animals; Anticonvulsants; Chronic Disease; Disease Models, Animal; Electroencephalography; Epilepsy,

2015
Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy.
    Biomaterials, 2016, Volume: 97

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chronic Disease; Disease Models, A

2016
COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats.
    Neuropharmacology, 2010, Volume: 58, Issue:2

    Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri

2010
Trigeminal neuralgia: a retrospective study of 188 Thai cases.
    Gerodontology, 2012, Volume: 29, Issue:2

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Carbamazepine; Chronic Diseas

2012
[Left-sided hemiparesis in a diabetic patient: chronic granulomatous encephalitis due to Acanthamoeba].
    Revista de neurologia, 2013, Feb-01, Volume: 56, Issue:3

    Topics: Acanthamoeba; Aged; Alcoholism; Amebiasis; Anti-Infective Agents; Atrial Fibrillation; Biopsy; Brain

2013
Is there a role for surgery in the management of dropped head syndrome?
    British journal of neurosurgery, 2004, Volume: 18, Issue:3

    Topics: Anticonvulsants; Cervical Vertebrae; Chronic Disease; Epilepsy, Frontal Lobe; Humans; Kyphosis; Magn

2004
High vulnerability to acute dystonic reactions: a case of antipsychotic exposure and uncontrolled seizure activity.
    Progress in neuro-psychopharmacology & biological psychiatry, 2005, Volume: 29, Issue:5

    Topics: Anticonvulsants; Antipsychotic Agents; Chronic Disease; Cytochrome P-450 CYP2D6; Dibenzothiazepines;

2005
Phenytoin reverses the chronic stress-induced impairment of memory consolidation for water maze training and depression of LTP in rat hippocampal CA1 region, but does not affect motor activity.
    Brain research. Cognitive brain research, 2005, Volume: 24, Issue:3

    Topics: Animals; Anticonvulsants; Chronic Disease; Data Interpretation, Statistical; Electrophysiology; Evok

2005
Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats.
    Epilepsia, 2005, Volume: 46, Issue:10

    Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Casse

2005
Periodontal and soft tissue prevention strategies for the adolescent dental patient.
    Dental clinics of North America, 2006, Volume: 50, Issue:1

    Topics: Adolescent; Amphetamines; Anticonvulsants; Central Nervous System Stimulants; Chronic Disease; Cyclo

2006
Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE.
    Brain : a journal of neurology, 2006, Volume: 129, Issue:Pt 12

    Topics: Action Potentials; Administration, Oral; Animals; Axons; Cell Count; Cervical Vertebrae; Chronic Dis

2006
Diminished response of CA1 neurons to antiepileptic drugs in chronic epilepsy.
    Epilepsia, 2007, Volume: 48, Issue:7

    Topics: Action Potentials; Animals; Anticonvulsants; Carbamazepine; Chronic Disease; Dentate Gyrus; Disease

2007
Development of tolerance to levetiracetam in rats with chronic epilepsy.
    Epilepsia, 2008, Volume: 49, Issue:7

    Topics: Animals; Anticonvulsants; Chromatography, Gas; Chronic Disease; Disease Models, Animal; Dose-Respons

2008
Refractory paroxysmal ventricular tachycardia.
    Annals of internal medicine, 1967, Volume: 67, Issue:6

    Topics: Atrial Fibrillation; Chronic Disease; Digoxin; Electrocardiography; Heart Ventricles; Humans; Hydroc

1967
Cardioversion as an adjunct to cardiac surgery.
    Vascular surgery, 1967, Volume: 1, Issue:1

    Topics: Adult; Anticoagulants; Atrial Fibrillation; Atrial Flutter; Cardiac Surgical Procedures; Chronic Dis

1967
Treatment of chronic ventricular dysrhythmias in the young.
    Pacing and clinical electrophysiology : PACE, 1981, Volume: 4, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Child; Child,

1981
Acquired craniofacial features associated with chronic phenytoin therapy.
    Clinical pediatrics, 1984, Volume: 23, Issue:12

    Topics: Adult; Chronic Disease; Epilepsy; Face; Female; Humans; Male; Maxillofacial Development; Phenytoin;

1984
Anticonvulsant drugs used in the treatment of lancinating pain. A comparison.
    Anaesthesia, 1981, Volume: 36, Issue:12

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Chronic Disease; Clonazepam; Female; Humans

1981
Benign chronic orofacial pain. Clinical criteria and therapeutic approaches.
    Postgraduate medicine, 1983, Volume: 74, Issue:3

    Topics: Biofeedback, Psychology; Carbamazepine; Chronic Disease; Humans; Nerve Block; Orthodontic Appliances

1983
Neurobiological studies of experimental diphenylhydantoin intoxication. II. Electrophysiological and electron microscopic studies of the rat cerebellum with chronic diphenylhydantoin intoxication.
    Folia psychiatrica et neurologica japonica, 1982, Volume: 36, Issue:4

    Topics: Animals; Cerebellum; Chronaxy; Chronic Disease; Evoked Potentials; Female; Microscopy, Electron; Oli

1982
[Five autopsied cases of chronic diphenylhydantoin intoxication -- with special reference to the distribution of cerebellar degeneration and marked degeneration of nucleus fasciculi dorsalis (author's transl)].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1980, Volume: 82, Issue:7

    Topics: Adult; Cerebellum; Chronic Disease; Female; Humans; Male; Phenytoin; Spinal Cord

1980
Possible drug interaction in chronic treatment of epileptic patients: serum level studies.
    Monographs in neural sciences, 1980, Volume: 5

    Topics: Adolescent; Adult; Anticonvulsants; Brain Damage, Chronic; Chronic Disease; Clonazepam; Drug Interac

1980
Neurobiological studies of experimental diphenylhydantoin intoxication. - I. Electron microscopic investigations of the rat cerebellum with chronic diphenylhydantoin intoxication.
    Folia psychiatrica et neurologica japonica, 1981, Volume: 35, Issue:4

    Topics: Animals; Axons; Cerebellar Nuclei; Cerebellum; Chronic Disease; Dendrites; Female; Microscopy, Elect

1981
[Repetitive serum determinations of anticonvulsants in epileptic patients].
    Arquivos de neuro-psiquiatria, 1993, Volume: 51, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Chronic Disease; Epilepsy; Female; Humans; Middle

1993
Effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic-gingival hyperplasia: in vivo and in vitro study.
    European journal of clinical pharmacology, 1995, Volume: 49, Issue:1-2

    Topics: Adult; Aged; Anticonvulsants; Chronic Disease; Female; Gingival Hyperplasia; Humans; In Vitro Techni

1995
Systemic vasculitis associated with long-term phenytoin therapy.
    The New Zealand medical journal, 1999, Mar-26, Volume: 112, Issue:1084

    Topics: Antibodies, Antinuclear; Anticonvulsants; Biopsy; Chronic Disease; Epilepsy; Humans; Male; Middle Ag

1999
Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain.
    Arquivos de neuro-psiquiatria, 1999, Volume: 57, Issue:4

    Topics: Analgesics; Animals; Anticonvulsants; Carbamazepine; Chronic Disease; Neuralgia; Phenytoin; Rats; Ra

1999
Phenobarbital and MK-801, but not phenytoin, improve the long-term outcome of status epilepticus.
    Annals of neurology, 2002, Volume: 51, Issue:2

    Topics: Animals; Anticonvulsants; Behavior, Animal; Chronic Disease; Dizocilpine Maleate; Excitatory Amino A

2002
Therapeutic and pharmacokinetic effects of increasing phenytoin in chronic epileptics on multiple drug therapy.
    Lancet (London, England), 1976, Aug-21, Volume: 2, Issue:7982

    Topics: Adult; Biological Availability; Chronic Disease; Dose-Response Relationship, Drug; Drug Therapy, Com

1976
Healthy and diseased gingiva.
    The Practitioner, 1975, Volume: 214, Issue:1281

    Topics: Adult; Child; Chronic Disease; Dental Plaque; Diabetes Complications; Gingiva; Gingival Diseases; Gi

1975
Comparative trial of valproate sodium and clonazepam in chronic epilepsy.
    Archives of neurology, 1979, Volume: 36, Issue:5

    Topics: Adult; Ataxia; Benzodiazepinones; Chronic Disease; Clonazepam; Drug Therapy, Combination; Epilepsy;

1979
Chronic diphenyl hydantoin encephalopathy in mentally retarded children and adolescent with severe epilepsy.
    Acta neurologica Scandinavica, 1979, Volume: 60, Issue:1

    Topics: Adolescent; Adult; Brain Diseases; Child; Child, Preschool; Chronic Disease; Epilepsy; Female; Human

1979
Decreased serum 24,25-dihydroxy vitamin D concentrations in children receiving chronic anticonvulsant therapy.
    British medical journal, 1979, Sep-01, Volume: 2, Issue:6189

    Topics: Adolescent; Calcium; Child; Child, Preschool; Chronic Disease; Dihydroxycholecalciferols; Humans; Hy

1979
Effects of different dosages of anticonvulsant drugs on mental performance in patients with chronic epilepsy.
    Acta neurologica Scandinavica, 1975, Volume: 52, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Child; Chronic Disease; Dose-Response Relationship, Drug; Epilep

1975
Chronic urticaria.
    The Journal of allergy and clinical immunology, 1975, Volume: 55, Issue:4

    Topics: Chronic Disease; Cytoplasmic Granules; Ephedrine; Female; Humans; Mast Cells; Middle Aged; Phenothia

1975
Drug use and distribution in a pain rehabilitation center.
    American journal of hospital pharmacy, 1975, Volume: 32, Issue:3

    Topics: Adult; Amitriptyline; Barbiturates; Chronic Disease; Diet; Female; Formularies, Hospital as Topic; H

1975
Letter: Drug use in a pain rehabilitation center.
    American journal of hospital pharmacy, 1975, Volume: 32, Issue:11

    Topics: Amitriptyline; Chronic Disease; Drug Combinations; Humans; Methadone; Pain; Phenytoin; Snake Venoms

1975
Fluctuations of plasma phenytoin levels on single dose and twice daily dose regimes.
    Proceedings of the Australian Association of Neurologists, 1975, Volume: 12

    Topics: Adolescent; Adult; Child; Chronic Disease; Drug Administration Schedule; Epilepsy; Female; Humans; M

1975
The protein binding of some drugs in plasma from patients with alcoholic liver disease.
    European journal of clinical pharmacology, 1975, Apr-04, Volume: 8, Issue:3-4

    Topics: Alcoholism; Blood Proteins; Chronic Disease; Dapsone; Fluoresceins; Humans; Liver Diseases; Pharmace

1975
Anticonvulsant-induced chronic pancreatitis. A case report.
    The Italian journal of gastroenterology, 1992, Volume: 24, Issue:5

    Topics: Adult; Anticonvulsants; Carbamazepine; Chronic Disease; Cytochrome P-450 Enzyme System; Epilepsy; Fr

1992
[A high-grade T-cell non-Hodgkin's lymphoma in a patients with tuberous sclerosis treated with hydantoins].
    Medicina clinica, 1991, Oct-19, Volume: 97, Issue:13

    Topics: Adult; Chronic Disease; Humans; Male; Mediastinal Neoplasms; Phenytoin; Precursor Cell Lymphoblastic

1991
[Chronic encephalopathy induced by phenytoin].
    Medicina clinica, 1991, Nov-09, Volume: 97, Issue:16

    Topics: Aged; Brain Diseases; Chronic Disease; Female; Humans; Phenytoin

1991
Langerhans cells in human chronic gingivitis and phenytoin-induced gingival hyperplasia.
    Archives of oral biology, 1990, Volume: 35, Issue:7

    Topics: Adult; Cell Count; Chronic Disease; Dental Plaque; Gingival Hyperplasia; Gingivitis; Humans; Langerh

1990
Dilantin-induced long-term bilateral total external ophthalmoplegia.
    Journal of clinical neuro-ophthalmology, 1986, Volume: 6, Issue:1

    Topics: Adult; Cerebral Angiography; Chronic Disease; Corpus Callosum; Female; Humans; Intracranial Arteriov

1986
Effect of phenytoin on the clinical signs and in vitro muscle twitch characteristics in horses with chronic intermittent rhabdomyolysis and myotonia.
    American journal of veterinary research, 1988, Volume: 49, Issue:12

    Topics: Administration, Oral; Animals; Chronic Disease; Creatine Kinase; Female; Gait; Horse Diseases; Horse

1988
Phenytoin chronic toxicity and associated psychosis.
    Drug intelligence & clinical pharmacy, 1988, Volume: 22, Issue:12

    Topics: Aged; Chronic Disease; Female; Humans; Phenytoin; Psychoses, Substance-Induced

1988
Alternative single anticonvulsant drug therapy for refractory epilepsy.
    Annals of neurology, 1986, Volume: 19, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Chronic Disease; Epilepsy; Humans; Phenobarbital; Phenytoin;

1986
Reversible chronic cerebellar ataxia after phenytoin intoxication: possible role of cerebellum in cognitive thought.
    Neurology, 1985, Volume: 35, Issue:8

    Topics: Adolescent; Cerebellar Ataxia; Cerebellum; Chronic Disease; Cognition; Electroencephalography; Elect

1985
Intracellular recording of spontaneous local responses in the chronic epileptogenic focus of a rhesus monkey.
    Experimental neurology, 1974, Volume: 42, Issue:1

    Topics: Aluminum Hydroxide; Animals; Cerebral Cortex; Chronic Disease; Electrophysiology; Haplorhini; Macaca

1974
An overview of chronic recurring headache.
    Wisconsin medical journal, 1972, Volume: 71, Issue:3

    Topics: Acute Disease; Analgesics; Antidepressive Agents; Anxiety; Chronic Disease; Cortisone; Diuretics; Er

1972
Skin melanin concentrations in schizophrenia.
    The British journal of psychiatry : the journal of mental science, 1972, Volume: 121, Issue:565

    Topics: Adult; Antipsychotic Agents; Chlorpromazine; Chronic Disease; Female; Humans; Male; Melanins; Phenyt

1972
Editoral: Rebound nystagmus--a cerebellar sign?
    JAMA, 1974, Feb-11, Volume: 227, Issue:6

    Topics: Brain Diseases; Brain Stem; Cerebellar Diseases; Cerebellar Neoplasms; Chronic Disease; Cranial Foss

1974
Mechanism and management of chaotic atrial mechanism.
    Cardiology, 1974, Volume: 59, Issue:2

    Topics: Acute Disease; Chronic Disease; Coronary Disease; Digitalis Glycosides; Drug Therapy, Combination; E

1974
Serum folate levels during anticonvulsant therapy with diphenylhydantoin.
    Journal of the American Geriatrics Society, 1973, Volume: 21, Issue:6

    Topics: Adult; Age Factors; Aged; Binding Sites; Chronic Disease; Erythrocytes, Abnormal; Folic Acid; Hemato

1973
Suspected neurotoxicity from intravenous penicillin: a patient case.
    American journal of hospital pharmacy, 1972, Volume: 29, Issue:5

    Topics: Acute Kidney Injury; Ampicillin; Blood Urea Nitrogen; Chronic Disease; Creatine; Diazepam; Gentamici

1972
[Comparison of 2 modern antiarrhythmic drugs: lidocaine and diphenylhydantoin].
    Giornale italiano di cardiologia, 1972, Volume: 2, Issue:4

    Topics: Arrhythmias, Cardiac; Brain; Chronic Disease; Hemodynamics; Humans; Hypotension; Lidocaine; Necrosis

1972
[Autopsy case of chronic diphenylhydantoin poisoning].
    No to shinkei = Brain and nerve, 1972, Volume: 24, Issue:2

    Topics: Autopsy; Cerebellum; Chronic Disease; Humans; Male; Middle Aged; Phenytoin; Poisoning

1972
Recurrent convulsions in Cape Town children.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1971, Jan-23, Volume: 45, Issue:4

    Topics: Age Factors; Brain Damage, Chronic; Child; Child, Preschool; Chronic Disease; Humans; Phenytoin; Sei

1971
Diphenylhydantoin in the prevention of recurring ventricular tachycardia.
    Circulation, 1971, Volume: 43, Issue:3

    Topics: Adult; Chronic Disease; Coronary Disease; Humans; Phenytoin

1971
Concurrent administration of phenobarbital and diphenylhydantoin: lack of an interference effect.
    Neurology, 1971, Volume: 21, Issue:4

    Topics: Adolescent; Adult; Child; Chronic Disease; Drug Antagonism; Epilepsy; Humans; Phenobarbital; Phenoth

1971
[Ultrastructural data on electron microscopy of barbiturate induced hypertrophic gingivitis. I. Changes in the covering epithelium].
    Schweizerische Monatsschrift fur Zahnheilkunde = Revue mensuelle suisse d'odonto-stomatologie, 1969, Volume: 79, Issue:4

    Topics: Chronic Disease; Gingival Hypertrophy; Gingivitis; Humans; Microscopy, Electron; Phenytoin

1969
Number of Purkinje cells in patients with grand mal epilepsy treated with diphenylhydantoin.
    Epilepsia, 1970, Volume: 11, Issue:3

    Topics: Acute Disease; Autopsy; Cell Count; Cerebellum; Chronic Disease; Phenytoin

1970
Treatment of recurrent paroxysmal ventricular tachycardia.
    American heart journal, 1970, Volume: 79, Issue:6

    Topics: Child; Chronic Disease; Electrocardiography; Humans; Male; Phenytoin; Procainamide; Propranolol; Tac

1970
Low specific gravity syndrome.
    Clinical chemistry, 1968, Volume: 14, Issue:5

    Topics: Adult; Anticonvulsants; Calcium; Chlorides; Chronic Disease; Creatinine; Epilepsy; Female; Humans; I

1968
[Experience with diphenylhydantoin (antisacer) in the management of cardiac arrhythmias].
    Schweizerische medizinische Wochenschrift, 1968, Aug-17, Volume: 98, Issue:33

    Topics: Acute Disease; Arrhythmias, Cardiac; Chronic Disease; Digitalis Glycosides; Drug Tolerance; Humans;

1968
[Permanent cerebellar damage through temporary overdase of hydantoin].
    Deutsche medizinische Wochenschrift (1946), 1969, Jun-20, Volume: 94, Issue:25

    Topics: Adult; Cerebellar Diseases; Chronic Disease; Electroencephalography; Epilepsy; Female; Humans; Pheny

1969
[Study on long-active effect of antiepileptic agents].
    No to shinkei = Brain and nerve, 1969, Volume: 21, Issue:7

    Topics: Adolescent; Adult; Chronic Disease; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Seizures

1969