Compounds > phenytoin
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phenytoin and Cerebellar Diseases

phenytoin has been researched along with Cerebellar Diseases in 43 studies

Cerebellar Diseases: Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, GAIT ATAXIA, and MUSCLE HYPOTONIA.

Research Excerpts

ExcerptRelevanceReference
"Phenytoin is known to be able to induce cerebellar atrophy in patients with epilepsy."7.79The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy. ( Borgio, JG; De Paola, L; Scola, RH; Silvado, C; Twardowschy, CA; Werneck, LC, 2013)
"There is some evidence that long-term phenytoin (PHT) use may occasionally give rise to irreversible cerebellar atrophy, but it is unclear whether such changes can occur after acute PHT intoxication."7.69Cerebellar atrophy after acute phenytoin intoxication. ( Bharucha, NE; Kuruvilla, T, 1997)
"A patient developed marked cerebellar atrophy after a single suicidal intoxication with 7 grams phenytoin."7.67Cerebellar atrophy following acute intoxication with phenytoin. ( Elger, CE; Galanski, M; Ludolph, AC; Masur, H, 1989)
"Phenytoin is known to be able to induce cerebellar atrophy in patients with epilepsy."3.79The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy. ( Borgio, JG; De Paola, L; Scola, RH; Silvado, C; Twardowschy, CA; Werneck, LC, 2013)
"There is some evidence that long-term phenytoin (PHT) use may occasionally give rise to irreversible cerebellar atrophy, but it is unclear whether such changes can occur after acute PHT intoxication."3.69Cerebellar atrophy after acute phenytoin intoxication. ( Bharucha, NE; Kuruvilla, T, 1997)
"A patient developed marked cerebellar atrophy after a single suicidal intoxication with 7 grams phenytoin."3.67Cerebellar atrophy following acute intoxication with phenytoin. ( Elger, CE; Galanski, M; Ludolph, AC; Masur, H, 1989)
"Phenytoin sodium intoxication of subacute onset may occur in cases of nonepileptic patients who receive phenytoin for suppression of cardiac arrhythmias."3.66Subacute phenytoin intoxication syndrome. ( Tindall, RS; Willerson, J, 1978)
"Clinical signs of ataxia can persist without radiological evidence of cerebellar atrophy, and cerebellar atrophy is seen without any clinical evidence of cerebellar dysfunction."2.82Phenytoin and damage to the cerebellum - a systematic review of published cases. ( Bradberry, SM; Day, R; Ferner, R, 2022)
"Marked cerebellar dysfunction and persistent vomiting were observed, with an initial serum phenytoin concentration of 181 micromol/L."1.32Phenytoin overdose complicated by prolonged intoxication and residual neurological deficits. ( Craig, S, 2004)
"Phenytoin has been shown to cause choreiform movements, peripheral neuropathy, and cognitive decline in some patients, but the pathological basis for these changes has not been elucidated."1.29Neuronal loss from the subthalamic nuclei in a patient with progressive chorea. ( Hedreen, JC; Sinard, JH, 1995)
"Reversible cerebellar dysfunction is a common manifestation of acute phenytoin toxicity."1.26[Diphenylhydantoin, epilepsy, cerebellar atrophy--histological and electron microscope examinations (author's transl)]. ( Breiden-Arends, C; Gullotta, F, 1981)
" In the absence of other demonstrable cause, the selective morphologic changes in the cerebellum are attributed to long-term administration of phenytoin."1.26Cerebellar degeneration following long-term phenytoin therapy. ( Ghatak, NR; McKinney, WM; Santoso, RA, 1976)
"During this treatment a severe mainly motor polyneuropathy occurred acutely which was more pronounced in the distal parts of the legs, and cerebellar symptoms were noted at the same time."1.25[Acute polyneuropathy caused by diphenylhydantoin intoxication (author's transl)]. ( Bajc, O; Meienberg, O, 1975)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-199031 (72.09)18.7374
1990's4 (9.30)18.2507
2000's5 (11.63)29.6817
2010's2 (4.65)24.3611
2020's1 (2.33)2.80

Authors

AuthorsStudies
Ferner, R1
Day, R1
Bradberry, SM1
Verma, R1
Tiwari, N1
Twardowschy, CA1
Werneck, LC1
Scola, RH1
Borgio, JG1
De Paola, L1
Silvado, C1
HANSEN, HA1
NORDQVIST, P1
SOURANDER, P1
Craig, S1
Chow, KM1
Szeto, CC1
Brostoff, JM1
Birns, J1
McCrea, D1
Hansen, OE1
Lund, MA1
Procházková, V1
Urban, P1
Moskowitz, H1
Milikow, E1
Takeichi, M1
Esser, J1
Brandt, T1
Koller, WC2
Glatt, SL2
Perlik, S1
Huckman, MS1
Fox, JH2
Breiden-Arends, C1
Gullotta, F1
McCrea, ES1
Rao, CV1
Diaconis, JN1
McLain, LW1
Martin, JT1
Allen, JH1
Sinard, JH1
Hedreen, JC1
Luef, G1
Chemelli, A1
Birbamer, G1
Aichner, F1
Bauer, G1
Jibiki, I1
Kido, H1
Matsuda, H1
Yamaguchi, N1
Hisada, K1
Kuruvilla, T1
Bharucha, NE1
Hironishi, M1
Tan, EK1
Chan, LL1
Auchus, AP1
Kaspar, U1
Ziegler, DK1
Meienberg, O1
Bajc, O1
Tindall, RS1
Willerson, J1
Sanders, JE1
Yeary, RA1
Fenner, WR1
Powers, JD1
Heim, M1
Morgner, J1
Ghatak, NR1
Santoso, RA1
McKinney, WM1
Chadwick, D1
Reynolds, EH2
Marsden, CD1
Masur, H1
Elger, CE1
Ludolph, AC1
Galanski, M1
Ueki, A1
Noguchi, T1
Sekitani, T1
Selhorst, JB1
Kaufman, B1
Horwitz, SJ1
Sharpe, JA1
Horne, PD1
Haring, RD1
Simmons, FB1
Julien, RM1
Coats, AC1
Viukari, NM1
Aho, K1
Iivanainen, M1
Viukari, M1
Höglmeier, H1
Wenzel, U1

Reviews

4 reviews available for phenytoin and Cerebellar Diseases

ArticleYear
Phenytoin and damage to the cerebellum - a systematic review of published cases.
    Expert opinion on drug safety, 2022, Volume: 21, Issue:7

    Topics: Adult; Ataxia; Atrophy; Cerebellar Ataxia; Cerebellar Diseases; Cerebellum; Humans; Phenytoin

2022
Probable cerebellar abnormality on 123I-IMP SPECT scans in epileptic patients with long-term high-dose phenytoin therapy. Based on observation of multiple cases.
    Acta neurologica, 1993, Volume: 15, Issue:1

    Topics: Adult; Amphetamines; Cerebellar Diseases; Cerebellum; Epilepsies, Partial; Female; Frontal Lobe; Fun

1993
[Diphenylhydantoin. Metabolism, pharmacokinetics, interactions and side effects].
    Schweizerische medizinische Wochenschrift, 1976, Jun-05, Volume: 106, Issue:23

    Topics: Anti-Anxiety Agents; Benzodiazepines; Bone and Bones; Bone Marrow; Carbamazepine; Cerebellar Disease

1976
Toxicity to the nervous system of diphenylhydantoin: a review.
    International journal of neurology, 1978, Volume: 11, Issue:4

    Topics: Adrenal Cortex Hormones; Animals; Cardiovascular Diseases; Cerebellar Ataxia; Cerebellar Diseases; C

1978

Other Studies

39 other studies available for phenytoin and Cerebellar Diseases

ArticleYear
Phenytoin intoxication induced by Mandrax (methaqualone).
    Epilepsy research, 2012, Volume: 98, Issue:2-3

    Topics: Anticonvulsants; Cerebellar Diseases; Diphenhydramine; Drug Combinations; Epilepsy; Humans; Male; Me

2012
The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy.
    Seizure, 2013, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Aged; Alleles; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Atrophy; Cerebella

2013
MEGALOBLASTIC ANEMIA AND NEUROLOGIC DISTURBANCES COMBINED WITH FOLIC ACID DEFICIENCY. OBSERVATIONS ON AN EPILEPTIC PATIENT TREATED WITH ANTICONVULSANTS.
    Acta medica Scandinavica, 1964, Volume: 176

    Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Avitaminosis; Barbiturates; Brai

1964
Phenytoin overdose complicated by prolonged intoxication and residual neurological deficits.
    Emergency medicine Australasia : EMA, 2004, Volume: 16, Issue:4

    Topics: Adult; Cerebellar Diseases; Charcoal; Critical Care; Drug Overdose; Emergency Medicine; Hemoperfusio

2004
Cerebral atrophy and skull thickening due to chronic phenytoin therapy.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2007, Jan-30, Volume: 176, Issue:3

    Topics: Adult; Anticonvulsants; Atrophy; Cerebellar Diseases; Diagnosis, Differential; Epilepsy; Female; Hum

2007
Phenytoin toxicity: an easily missed cause of cerebellar syndrome.
    Journal of clinical pharmacy and therapeutics, 2008, Volume: 33, Issue:2

    Topics: Aged; Anticonvulsants; Cerebellar Diseases; Epilepsy; Humans; Male; Middle Aged; Phenytoin

2008
[Acute cerebellar ataxia associated with infectious mononucleosis].
    Nordisk medicin, 1967, Feb-02, Volume: 77, Issue:5

    Topics: Adolescent; Adult; Ataxia; Blood Cell Count; Cerebellar Diseases; Child, Preschool; Encephalitis; Hu

1967
[Hydantoin atrophy (degeneration) of the cerebellum].
    Ceskoslovenska neurologie a neurochirurgie, 1984, Volume: 47, Issue:4

    Topics: Adolescent; Adult; Atrophy; Cerebellar Diseases; Female; Humans; Male; Phenytoin

1984
Case report 285. Diagnosis: osteomalacia (rickets) and cerebellar atrophy secondary to the effects of diphenylhydantoin (dilantin).
    Skeletal radiology, 1984, Volume: 12, Issue:4

    Topics: Cerebellar Diseases; Child; Female; Femoral Fractures; Humans; Osteomalacia; Phenytoin; Rickets; Tom

1984
Neurobiological studies of experimental diphenylhydantoin intoxication--III. Electron microscopic studies on development and disintegration mechanism of altered axon terminals and synaptic endings in rat cerebellum with chronic diphenylhydantoin intoxicat
    Folia psychiatrica et neurologica japonica, 1983, Volume: 37, Issue:4

    Topics: Animals; Axons; Cerebellar Diseases; Cerebellum; Female; Intracellular Membranes; Microscopy, Electr

1983
[Pharmacologically-caused eye movement disorders--differential diagnosis and mechanisms of action].
    Fortschritte der Neurologie-Psychiatrie, 1983, Volume: 51, Issue:2

    Topics: Alcoholism; Barbiturates; Cerebellar Diseases; Diagnosis, Differential; Eye Movements; Fixation, Ocu

1983
Cerebellar atrophy demonstrated by computed tomography.
    Neurology, 1981, Volume: 31, Issue:4

    Topics: Adult; Alcoholism; Atrophy; Carcinoma; Cerebellar Diseases; Cerebellar Neoplasms; Cerebral Ventricul

1981
[Diphenylhydantoin, epilepsy, cerebellar atrophy--histological and electron microscope examinations (author's transl)].
    Fortschritte der Neurologie-Psychiatrie, 1981, Volume: 49, Issue:11

    Topics: Adult; Atrophy; Cerebellar Diseases; Cerebellum; Endoplasmic Reticulum; Epilepsy; Female; Humans; Ma

1981
Roentgenographic changes during long-term diphenylhydantoin therapy.
    Southern medical journal, 1980, Volume: 73, Issue:3

    Topics: Abnormalities, Drug-Induced; Bone and Bones; Bone Diseases; Cerebellar Diseases; Humans; Lung; Lymph

1980
Cerebellar degeneration due to chronic phenytoin therapy.
    Annals of neurology, 1980, Volume: 7, Issue:1

    Topics: Adult; Atrophy; Cerebellar Diseases; Female; Humans; Male; Middle Aged; Phenytoin; Seizures; Tomogra

1980
Phenytoin-induced cerebellar degeneration.
    Annals of neurology, 1980, Volume: 8, Issue:2

    Topics: Cerebellar Diseases; Humans; Nerve Degeneration; Phenytoin

1980
Neuronal loss from the subthalamic nuclei in a patient with progressive chorea.
    Movement disorders : official journal of the Movement Disorder Society, 1995, Volume: 10, Issue:3

    Topics: Aged; Aged, 80 and over; Astrocytes; Brain; Cell Count; Cerebellar Diseases; Chorea; Epilepsy, Post-

1995
Phenytoin overdosage and cerebellar atrophy in epileptic patients: clinical and MRI findings.
    European neurology, 1994, Volume: 34 Suppl 1

    Topics: Adult; Atrophy; Cerebellar Diseases; Cerebellum; Drug Overdose; Epilepsy; Female; Humans; Magnetic R

1994
Cerebellar atrophy after acute phenytoin intoxication.
    Epilepsia, 1997, Volume: 38, Issue:4

    Topics: Acute Disease; Adult; Atrophy; Cerebellar Diseases; Cerebellum; Drug Overdose; Humans; Magnetic Reso

1997
[Cerebellar atrophy associated with phenytoin intoxication].
    No to shinkei = Brain and nerve, 2000, Volume: 52, Issue:3

    Topics: Adult; Atrophy; Cerebellar Diseases; Humans; Male; Phenytoin; Poisoning

2000
Phenytoin cerebellopathy without epilepsy.
    Acta neurologica Scandinavica, 2001, Volume: 104, Issue:1

    Topics: Anticonvulsants; Atrophy; Cerebellar Diseases; Female; Humans; Middle Aged; Motor Skills Disorders;

2001
[Acute polyneuropathy caused by diphenylhydantoin intoxication (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1975, Jul-18, Volume: 100, Issue:29

    Topics: Acute Disease; Adult; Cerebellar Diseases; Epilepsy, Tonic-Clonic; Humans; Male; Peripheral Nervous

1975
Subacute phenytoin intoxication syndrome.
    Archives of internal medicine, 1978, Volume: 138, Issue:7

    Topics: Arrhythmias, Cardiac; Cerebellar Diseases; Humans; Male; Mental Disorders; Middle Aged; Peripheral N

1978
Interaction of phenytoin with chloramphenicol or pentobarbital in the dog.
    Journal of the American Veterinary Medical Association, 1979, Jul-15, Volume: 175, Issue:2

    Topics: Administration, Oral; Animals; Cerebellar Diseases; Chloramphenicol; Dog Diseases; Dogs; Drug Intera

1979
[Toxic "atrophie cerebelleuse". (problems associated with permanent cerebellar damage due to chronic diphenylhydantion intoxication)].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1978, Volume: 30, Issue:3

    Topics: Adult; Atrophy; Brain Damage, Chronic; Cerebellar Diseases; Epilepsy; Female; Humans; Phenytoin; Rad

1978
Cerebellar degeneration following long-term phenytoin therapy.
    Neurology, 1976, Volume: 26, Issue:9

    Topics: Aged; Cerebellar Cortex; Cerebellar Diseases; Epilepsy, Tonic-Clonic; Female; Humans; Long-Term Care

1976
Anticonvulsant-induced dyskinesias: a comparison with dyskinesias induced by neuroleptics.
    Journal of neurology, neurosurgery, and psychiatry, 1976, Volume: 39, Issue:12

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cerebellar Diseases; Chorea; Dyskinesia, Dr

1976
Cerebellar atrophy following acute intoxication with phenytoin.
    Neurology, 1989, Volume: 39, Issue:3

    Topics: Adult; Atrophy; Cerebellar Diseases; Cerebellum; Humans; Male; Phenytoin; Tomography, X-Ray Computed

1989
[Neuro-otological findings in acute diphenylhydantoin (DPH) intoxication].
    Nihon Jibiinkoka Gakkai kaiho, 1985, Volume: 88, Issue:7

    Topics: Acute Disease; Adult; Brain Stem; Cerebellar Diseases; Female; Humans; Phenytoin

1985
Diphenylhydantoin-induced cerebellar degeneration.
    Archives of neurology, 1972, Volume: 27, Issue:5

    Topics: Adolescent; Cerebellar Ataxia; Cerebellar Diseases; Child; Electroencephalography; Epilepsy; Female;

1972
Iatrogenic disorders in epilepsy.
    Modern trends in neurology, 1970, Volume: 5, Issue:0

    Topics: Adrenal Insufficiency; Anemia, Macrocytic; Animals; Anticonvulsants; Cats; Cerebellar Diseases; Drug

1970
Editoral: Rebound nystagmus--a cerebellar sign?
    JAMA, 1974, Feb-11, Volume: 227, Issue:6

    Topics: Brain Diseases; Brain Stem; Cerebellar Diseases; Cerebellar Neoplasms; Chronic Disease; Cranial Foss

1974
Long term anticonvulsant therapy and cerebellar atrophy.
    Journal of the Irish Medical Association, 1973, Mar-24, Volume: 66, Issue:6

    Topics: Adult; Avitaminosis; Cerebellar Diseases; Cranial Fossa, Posterior; Epilepsy, Tonic-Clonic; Female;

1973
Cerebellar defects detectable by electronystagmography calibration.
    Archives of otolaryngology (Chicago, Ill. : 1960), 1973, Volume: 98, Issue:1

    Topics: Adolescent; Adult; Aged; Astrocytoma; Blindness; Brain Diseases; Cerebellar Ataxia; Cerebellar Disea

1973
Anticonvulsant action of diphenylhydantoin in mice with genetic cerebellar degeneration.
    The Journal of pharmacology and experimental therapeutics, 1972, Volume: 180, Issue:2

    Topics: Animals; Anticonvulsants; Cerebellar Diseases; Electroshock; Hindlimb; Mice; Mice, Inbred Strains; M

1972
Central electronystagmographic abnormalities.
    Archives of otolaryngology (Chicago, Ill. : 1960), 1970, Volume: 92, Issue:1

    Topics: Adult; Barbiturates; Brain Neoplasms; Brain Stem; Central Nervous System; Central Nervous System Dis

1970
Digoxin-phenytoin interaction.
    British medical journal, 1970, Apr-04, Volume: 2, Issue:5700

    Topics: Ataxia; Cerebellar Diseases; Coma; Digoxin; Humans; Male; Middle Aged; Phenytoin

1970
[Phenytoin intoxication--an insidous complication in the treatment of epilepsy].
    Duodecim; laaketieteellinen aikakauskirja, 1970, Volume: 86, Issue:17

    Topics: Adult; Body Weight; Cerebellar Diseases; Child; Epilepsy; Female; Humans; Male; Movement Disorders;

1970
[Permanent cerebellar damage through temporary overdase of hydantoin].
    Deutsche medizinische Wochenschrift (1946), 1969, Jun-20, Volume: 94, Issue:25

    Topics: Adult; Cerebellar Diseases; Chronic Disease; Electroencephalography; Epilepsy; Female; Humans; Pheny

1969