phenytoin and Central Hypothyroidism studies

Research Excerpts

Excerpt	Relevance	Reference
" He had been administered phenytoin and gabapentin for the treatment of symptomatic traumatic epilepsy 8 years before."	7.88	Hypothyroidism induced by phenytoin and gabapentin: A Case Report. ( Ishii, K; Miyake, Z; Tamaoka, A, 2018)
"A 42-year-old woman who presented phenytoin intoxication induced by acute hypothyroidism was reported."	7.68	[A case of phenytoin intoxication induced by hypothyroidism]. ( Fujitake, J; Horii, K; Ishikawa, K; Shimbo, S; Tatsuoka, Y, 1991)
" He had been administered phenytoin and gabapentin for the treatment of symptomatic traumatic epilepsy 8 years before."	3.88	Hypothyroidism induced by phenytoin and gabapentin: A Case Report. ( Ishii, K; Miyake, Z; Tamaoka, A, 2018)
"The results indicated an increased risk of hypothyroidism among patients using AEDs, especially phenytoin, valproate, phenobarbital, carbamazepine, and oxcarbazepine."	3.79	Use of antiepileptic drugs and risk of hypothyroidism. ( Hsieh, CY; Lai, EC; Lin, SJ; Yang, YH, 2013)
"A 42-year-old woman who presented phenytoin intoxication induced by acute hypothyroidism was reported."	3.68	[A case of phenytoin intoxication induced by hypothyroidism]. ( Fujitake, J; Horii, K; Ishikawa, K; Shimbo, S; Tatsuoka, Y, 1991)
" We measured FT4 in a total of 325 serum samples from euthyroid patients; patients receiving replacement thyroxin; patients receiving estrogens or who were pregnant; hyperthyroid, hypothyroid, and non- thyroidally ill patients; and patients receiving salicylates, phenytoin, or heparin."	3.67	Estimation of free thyroxin with a new thyroxin analog and a porous-glass solid phase. ( Gilbert, SS; Shuler, SE; Witherspoon, LR, 1984)
"Quantitative histomorphometric analyses of iliac crest biopsy specimens were performed after tetracycline double-labeling in 41 normal individuals, 20 hyper- and 10 hypothyroid patients, 18 patients with primary hyperparathyroidism, 20 epileptic patients receiving long-term anticonvulsant therapy, and 17 patients after jejunoileal bypass for morbid obesity."	3.66	Trabecular bone mineralization lag time determined by tetracycline double-labeling in normal and certain pathological conditions. ( Melsen, F; Mosekilde, L, 1980)
"Two patients on long-term anti-epileptic treatment, one with both phenytoin and carbamazepine, the other with carbamazepine, developed clinical hypothyroidism."	3.66	Hypothyroidism induced by anti-epileptic therapy. ( Aanderud, S; Strandjord, RE, 1980)
"The metabolism of phenytoin was studied in 9 hyperthyroid and 7 hypothyroid patients before and after treatment with either antithyroid drugs or 1-thyroxine."	3.66	Unaltered metabolism of phenytoin in thyroid disorders. ( Kampmann, JP; Lumholtz, BI; Mølholm Hansen, J; Siersbaek-Nielsen, K; Skovsted, L, 1978)
"The prevalence of unrecognized primary hypothyroidism and hyperthyroidism was 5·2% and 2·8%, respectively."	1.37	Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study. ( de Rijke, YB; van Toor, H; Visser, TJ; Visser, WE, 2011)
"Phenytoin levels were measured and found to be grossly elevated at 170 mmol/L."	1.35	Phenytoin toxicity and thyroid dysfunction. ( Betteridge, T; Fink, J, 2009)
"Phenytoin is a widely used anticonvulsant which has a relatively narrow therapeutic range of serum concentrations, 40-80 mmol/l (10-20 mg/l)."	1.29	Hypothyroxinemia and phenytoin toxicity: a vicious circle. ( Sarich, TC; Wright, JM, 1996)
"Hyperthyroidism was found in 3/402 (0."	1.26	The prevalence of thyroid dysfunction in mentally handicapped in-patients. ( Cameron, J; Goonetilleke, AS; Hughes, VC, 1982)

Timeframe	Studies, this research(%)	All Research%
pre-1990	41 (83.67)	18.7374
1990's	4 (8.16)	18.2507
2000's	1 (2.04)	29.6817
2010's	3 (6.12)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Miyake, Z	1
Ishii, K	1
Tamaoka, A	1
Lai, EC	1
Yang, YH	1
Lin, SJ	1
Hsieh, CY	1
Betteridge, T	1
Fink, J	1
Visser, WE	1
de Rijke, YB	1
van Toor, H	1
Visser, TJ	1
MURPHY, BE	2
PATTEE, CJ	2
Hughes, VC	1
Cameron, J	1
Goonetilleke, AS	1
Postellon, DC	1
Witherspoon, LR	1
Shuler, SE	1
Gilbert, SS	1
Blackshear, JL	1
Schultz, AL	1
Napier, JS	1
Stuart, DD	1
Gambert, SR	1
Garthwaite, TL	1
Melsen, F	1
Mosekilde, L	1
Aanderud, S	1
Strandjord, RE	1
Schwarz, U	1
Lämmle, B	1
Six, P	1
Haas, HG	1
Tiihonen, M	1
Liewendahl, K	2
Waltimo, O	1
Ojala, M	1
Välimäki, M	1
Gonzalez, IG	1
Martin Luquero, M	1
Marcos Martinez, L	1
Gargallo Fernandez, MA	1
Sarich, TC	1
Wright, JM	1
Mølholm Hansen, J	1
Skovsted, L	1
Kampmann, JP	1
Lumholtz, BI	1
Siersbaek-Nielsen, K	3
Rabl, W	1
Windorfer, A	1
Rosengård, S	1
Lamberg, BA	1
Sollberg, G	1
Klein, HD	1
Sollberg, S	1
Jiang, NS	1
Tue, KA	1
Nicholson, G	1
Liebling, LI	1
Hall, RA	1
Hauteville, A	1
Horii, K	1
Fujitake, J	1
Tatsuoka, Y	1
Ishikawa, K	1
Shimbo, S	1
Gilsanz Peral, A	1
Costa Talens, P	1
Gómez Balaguer, M	1
Finnerty, JP	1
Kushnir, M	1
Weinstein, R	1
Landau, B	1
Shavit, G	1
Bechar, M	1
Gadoth, N	1
Surks, MI	1
Faber, J	1
Lumholtz, IB	1
Kirkegaard, C	1
Poulsen, S	1
Jørgensen, PH	1
Friis, T	2
Hamburger, JI	1
Meier, DA	1
Horiguchi, T	1
Nusynowitz, ML	1
Strader, WJ	1
Chan, V	1
Williams, EM	1
Gold, A	1
Kolendorf, K	1
Hansen, MJ	1
Reynolds, EH	1
Parker, WA	1
Gumnit, RJ	1
Gharib, H	1
Ryan, RJ	1
Mayberry, WE	1
Sakurada, T	2
Yamaguchi, T	2
Yamamoto, M	2
Tayama, S	1
Demura, H	1
Giménez-Roldán, S	1
Esteban, A	1
Brookeman, VA	1
Saito, S	1
Demura, R	1
Wu, NF	1
Kushnick, T	1
Sparagana, M	1
Phillips, G	1
Kucera, L	1
Zaninovich, AA	1
Farach, H	1
Ezrin, C	1
Volpé, R	1
Jubiz, W	2
Meikle, AW	1
Tyler, FH	1
West, CD	2
Bigler, AH	1
Kumagai, LF	1
Fulop, M	1
Widrow, DR	1
Colmers, RA	1
Epstein, EJ	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
The Effects of Thyroid Hormone on Cytochrome P450 and P-Glycoprotein Activity in Thyroid Cancer Patients[NCT00080574]			Phase 2	20 participants	Interventional	2004-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Diagnosis and treatment of congenital hypothyroidism. Comprehensive therapy, 1983, Volume: 9, Issue:2 Topics: Cholestyramine Resin; Congenital Hypothyroidism; Drug Interactions; Female; Humans; Hypothyroidism;	1983
Triiodothyronine (T3) radioimmunoassay. A critical evaluation. Mayo Clinic proceedings, 1972, Volume: 47, Issue:12 Topics: Benzoates; Binding Sites; Cross Reactions; Diet; Ethylmercury Compounds; Evaluation Studies as Topic	1972

Article	Year
Thyroid status of patients receiving long-term anticonvulsant therapy assessed by peripheral parameters: a placebo-controlled thyroxine therapy trial. Epilepsia, 1995, Volume: 36, Issue:11 Topics: Adult; Age Distribution; Anticonvulsants; Carbamazepine; Comorbidity; Cross-Over Studies; Double-Bli	1995
Serum thyroxine by competitive protein binding analysis: clinical, statistical and comparative evaluation. The Journal of clinical endocrinology and metabolism, 1969, Volume: 29, Issue:2 Topics: Blood Chemical Analysis; Blood Proteins; Chemistry, Clinical; Chromatography, Ion Exchange; Clinical	1969

phenytoin and Central Hypothyroidism

Research Excerpts

Research

Studies (49)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Hypothyroidism induced by phenytoin and gabapentin: A Case Report. Medicine, 2018, Volume: 97, Issue:43 Topics: Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobutyric	2018
Use of antiepileptic drugs and risk of hypothyroidism. Pharmacoepidemiology and drug safety, 2013, Volume: 22, Issue:10 Topics: Anticonvulsants; Databases, Factual; Epilepsy; Humans; Hypothyroidism; Phenytoin; Risk Factors; Taiw	2013
Phenytoin toxicity and thyroid dysfunction. The New Zealand medical journal, 2009, Sep-25, Volume: 122, Issue:1303 Topics: Anticonvulsants; Epilepsy; Female; Follow-Up Studies; Humans; Hypothyroidism; Middle Aged; Phenytoin	2009
Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study. Clinical endocrinology, 2011, Volume: 75, Issue:3 Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cohort Studies; Cross-Sectional Studies; Drug Therapy,	2011
DETERMINATION OF THYROXINE UTILIZING THE PROPERTY OF PROTEIN-BINDING. The Journal of clinical endocrinology and metabolism, 1964, Volume: 24 Topics: Aspirin; Bilirubin; Blood Chemical Analysis; Blood Proteins; Cholesterol; Glucose; Heparin; Hyperthy	1964
The prevalence of thyroid dysfunction in mentally handicapped in-patients. Journal of mental deficiency research, 1982, Volume: 26 (Pt 2) Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cross-Sectional Studies; Down Syndrome; Female; Hu	1982
Estimation of free thyroxin with a new thyroxin analog and a porous-glass solid phase. Clinical chemistry, 1984, Volume: 30, Issue:5 Topics: Female; Glass; Heparin; Humans; Hyperthyroidism; Hypothyroidism; Male; Methods; Phenytoin; Pregnancy	1984
Thyroxine replacement requirements in hypothyroid patients receiving phenytoin. Annals of internal medicine, 1983, Volume: 99, Issue:3 Topics: Adult; Drug Administration Schedule; Female; Humans; Hypothyroidism; Phenytoin; Recurrence; Thyrotro	1983
The effect of diphenylhydantoin on basal and stimulated thyroid stimulating hormone (TSH) and prolactin secretion in euthyroid and hypothyroid rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1980, Volume: 12, Issue:11 Topics: Animals; Hypothyroidism; Male; Phenytoin; Prolactin; Rats; Thyrotropin; Thyrotropin-Releasing Hormon	1980
Trabecular bone mineralization lag time determined by tetracycline double-labeling in normal and certain pathological conditions. Acta pathologica et microbiologica Scandinavica. Section A, Pathology, 1980, Volume: 88, Issue:2 Topics: Adult; Aged; Biopsy; Bone and Bones; Bone Diseases; Female; Humans; Hyperparathyroidism; Hyperthyroi	1980
Hypothyroidism induced by anti-epileptic therapy. Acta neurologica Scandinavica, 1980, Volume: 61, Issue:5 Topics: Aged; Carbamazepine; Female; Humans; Hypothyroidism; Middle Aged; Phenytoin	1980
Polyendocrine deficiency syndrome. Occurrence in a patient with depressed IgA titers receiving phenytoin. Archives of internal medicine, 1980, Volume: 140, Issue:9 Topics: Addison Disease; Adult; Amenorrhea; Autoimmune Diseases; Endocrine System Diseases; Female; Humans;	1980
[Study of the influence of anticonvulsant treatment on thyroid function]. Anales de medicina interna (Madrid, Spain : 1984), 1995, Volume: 12, Issue:12 Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Enzyme-Linked Immunosorbent Assay; E	1995
Hypothyroxinemia and phenytoin toxicity: a vicious circle. Drug metabolism and drug interactions, 1996, Volume: 13, Issue:2 Topics: Anticonvulsants; Enzyme Induction; Female; Humans; Hypothyroidism; Liver; Middle Aged; Phenytoin; Th	1996
Unaltered metabolism of phenytoin in thyroid disorders. Acta pharmacologica et toxicologica, 1978, Volume: 42, Issue:5 Topics: Adult; Aged; Antipyrine; Female; Half-Life; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Ag	1978
[Myopathia and hypothyroidism caused by diphenylhydantoin]. Deutsche medizinische Wochenschrift (1946), 1977, Dec-23, Volume: 102, Issue:51 Topics: Humans; Hypothyroidism; Muscular Diseases; Phenytoin	1977
Nuclear binding of triiodothyronine and thyroxine in lymphocytes from subjects with hyperthyroidism, hypothyroidism and resistance to thyroid hormones. Clinica chimica acta; international journal of clinical chemistry, 1978, Feb-01, Volume: 83, Issue:1-2 Topics: Adult; Binding, Competitive; Cell Nucleus; Cells, Cultured; Female; Humans; Hyperthyroidism; Hypothy	1978
[Myopathy and hypothyreosis caused by diphenylhydantoin]. Deutsche medizinische Wochenschrift (1946), 1977, Apr-22, Volume: 102, Issue:16 Topics: Adult; Humans; Hypothyroidism; Male; Muscular Diseases; Phenytoin; Time Factors	1977
Determination of free thyroxine in serum by radioimmunoassay. Clinical chemistry, 1977, Volume: 23, Issue:9 Topics: Cross Reactions; Humans; Hyperthyroidism; Hypothyroidism; Microchemistry; Phenytoin; Radioimmunoassa	1977
Thyroid dysfunction in female psychiatric patients. The British journal of psychiatry : the journal of mental science, 1976, Volume: 129 Topics: Adult; Age Factors; Aged; Aspirin; Female; Humans; Hypothyroidism; Lithium; Mental Disorders; Middle	1976
[Hydantoin induced gingival hyperplasia]. Annales medico-psychologiques, 1975, Volume: 1, Issue:1 Topics: Cholesterol; Gingiva; Gingival Hyperplasia; Humans; Hypothyroidism; Lipids; Phenytoin; Thyroid Funct	1975
[A case of phenytoin intoxication induced by hypothyroidism]. Rinsho shinkeigaku = Clinical neurology, 1991, Volume: 31, Issue:5 Topics: Acute Disease; Adult; Cerebellar Ataxia; Female; Humans; Hypothyroidism; Phenytoin; Thyroid Gland; T	1991
[Diphenylhydantoin and primary hypothyroidism]. Revista clinica espanola, 1986, Volume: 179, Issue:8 Topics: Epilepsy; Female; Humans; Hypothyroidism; Middle Aged; Phenytoin	1986
Hypothyroidism and phenytoin intoxication. Annals of internal medicine, 1985, Volume: 103, Issue:4 Topics: Aged; Humans; Hypothyroidism; Phenytoin; Thyrotropin-Releasing Hormone	1985
Hypothyroidism and phenytoin intoxication. Annals of internal medicine, 1985, Volume: 102, Issue:3 Topics: Aged; Epilepsy; Female; Humans; Hypothyroidism; Phenytoin; Thyrotropin; Thyroxine	1985
Hypothyroidism and phenytoin. Annals of internal medicine, 1985, Volume: 102, Issue:6 Topics: Humans; Hypothyroidism; Phenytoin; Thyroid Hormones	1985
The effects of phenytoin (diphenylhydantoin) on the extrathyroidal turnover of thyroxine, 3,5,3'-triiodothyronine, 3,3',5'-triiodothyronine, and 3',5'-diiodothyronine in man. The Journal of clinical endocrinology and metabolism, 1985, Volume: 61, Issue:6 Topics: Aged; Animals; Biotransformation; Diiodothyronines; Female; Humans; Hypothyroidism; In Vitro Techniq	1985
How to use modern thyroid function tests. American family physician, 1971, Volume: 3, Issue:5 Topics: Androgens; Antithyroid Agents; Drug Therapy; Estrogens; Humans; Hyperthyroidism; Hypothyroidism; Iod	1971
[Clinical study on determination of blood thyroid hormone levels using the protein binding test--free thyroxine index in young children]. Nihon Shonika Gakkai zasshi. Acta paediatrica Japonica, 1971, Volume: 75, Issue:9 Topics: Age Factors; Androgens; Antithyroid Agents; Child; Child, Preschool; Down Syndrome; Dwarfism, Pituit	1971
A new estimate of the thyroxine binding globulin capacity. American journal of clinical pathology, 1972, Volume: 58, Issue:6 Topics: Binding, Competitive; Chromatography; Contraceptives, Oral; Female; Humans; Hyperthyroidism; Hypothy	1972
The assay of urinary thyroid hormones for assessing thyroid function. Annals of clinical biochemistry, 1974, Volume: 11, Issue:4 Topics: Adult; Circadian Rhythm; Diagnosis, Differential; Estrogens; Female; Humans; Hyperthyroidism; Hypoth	1974
Cellular basis of cardiac dysrhythmias. Advances in cardiology, 1974, Volume: 12, Issue:0 Topics: Action Potentials; Arrhythmias, Cardiac; Benzofurans; Bretylium Compounds; Cell Membrane Permeabilit	1974
Clinical evaluation of a new method for the determination of serum thyroxine. The Journal of clinical endocrinology and metabolism, 1966, Volume: 26, Issue:3 Topics: Adult; Blood; Cholesterol; Estrogens; Female; Humans; Hyperthyroidism; Hypoproteinemia; Hypothyroidi	1966
Evaluation of thyroid status with "effective thyroxine ratio" (E.T.R.). Acta endocrinologica, 1974, Volume: 77, Issue:2 Topics: Adolescent; Adult; Aged; Aspirin; Depression, Chemical; Estrogens; Evaluation Studies as Topic; Fema	1974
Iatrogenic disorders in epilepsy. Modern trends in neurology, 1970, Volume: 5, Issue:0 Topics: Adrenal Insufficiency; Anemia, Macrocytic; Animals; Anticonvulsants; Cats; Cerebellar Diseases; Drug	1970
Diphenylhydantoin toxicity: dose-dependent blood dyscrasia. Neurology, 1974, Volume: 24, Issue:12 Topics: Adult; Amenorrhea; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Hypothermia; Hypothyr	1974
[Radioimmunoassay of triiodothyronine]. Nihon Naibunpi Gakkai zasshi, 1972, Nov-20, Volume: 48, Issue:8 Topics: Congenital Hypothyroidism; Dinitrophenols; Humans; Hyperthyroidism; Hypothyroidism; Iodine Isotopes;	1972
Orbicularis oculi "myotonia" in hypothyroid myopathy. European neurology, 1973, Volume: 9, Issue:1 Topics: Cold Temperature; Diazepam; Electromyography; Humans; Hypothyroidism; Male; Middle Aged; Muscle Cont	1973
Non-Gaussian distribution of serum thyroxine levels for euthyroid population. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1973, Volume: 14, Issue:9 Topics: Adolescent; Adult; Aged; Androgens; Binding, Competitive; Child; Child, Preschool; Estrogens; Female	1973
Radioimmunoassay of triiodothyronine. The Tohoku journal of experimental medicine, 1973, Volume: 110, Issue:4 Topics: Animals; Cross Reactions; Dinitrophenols; Humans; Hyperthyroidism; Hypothyroidism; Imidazoles; Immun	1973
The Beckwith-Wiedemann syndrome. The exomphalos-macroglossia-gigantism syndrome. Clinical pediatrics, 1974, Volume: 13, Issue:5 Topics: Abnormalities, Multiple; Blood Glucose; Brain Damage, Chronic; Congenital Hypothyroidism; Diagnosis,	1974
Lack of significant binding of L-triiodothyronine by thyroxine-binding globulin in vivo as demonstrated by acute disappearance of 131-I-labeled triiodothyronine. The Journal of clinical investigation, 1966, Volume: 45, Issue:8 Topics: Adolescent; Adult; Aged; Epilepsy; Estrogens; Female; Hepatitis; Humans; Hyperthyroidism; Hypothyroi	1966
Serum thyroxine specific activity (T4SA) in the diagnosis of thyroid dysfunction. The American journal of medicine, 1969, Volume: 47, Issue:5 Topics: Blood Protein Disorders; Chromatography, Paper; Estrogens; Humans; Hyperthyroidism; Hypothyroidism;	1969
Estimation of thyroxine production rates in non-steady states. The Journal of clinical endocrinology and metabolism, 1972, Volume: 34, Issue:6 Topics: Contraceptives, Oral; Female; Humans; Hyperthyroidism; Hypothyroidism; Injections, Intravenous; Iodi	1972
Possible diphenylhydantoin-induced arrhythmia in hypothyroidism. JAMA, 1966, May-02, Volume: 196, Issue:5 Topics: Hypothyroidism; Phenytoin; Rheumatic Heart Disease; Tachycardia	1966