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phenytoin and Cardiovascular Diseases

phenytoin has been researched along with Cardiovascular Diseases in 18 studies

Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Research Excerpts

ExcerptRelevanceReference
"Twenty-nine complications were burning pain at the IV site, and 36 were related to excessive total dose of phenytoin and resultant drug intoxication."5.27Complications of intravenous phenytoin for acute treatment of seizures. Recommendations for usage. ( Drury, LR; Earnest, MP; Marx, JA, 1983)
"After excluding patients in the monotherapy group with vascular etiology or previous cardiovascular events, in the remaining 400 patients, enzyme-inducer AEDs (EIAEDs), especially phenytoin (PHT), were associated with higher prevalence of dyslipidemia (PRa 1."3.85Prevalence of cardiovascular risk factors in people with epilepsy. ( Díez, L; Elosua, R; Gomez, A; Moreira, A; Roquer, J; Vivanco-Hidalgo, RM, 2017)
"From April 8, 1982, through June 1984, 11 patients in a single hospital experienced 17 episodes of limb edema and discoloration after the intravenous (IV) administration of phenytoin sodium (Dilantin)."3.67Severe soft-tissue injury following intravenous infusion of phenytoin. Patient and drug administration risk factors. ( Arrowsmith, JB; Buchanan, C; Graham, DR; Kilarski, DJ; Spengler, RF; Von Behren, L, 1988)
"To determine the adequacy of seizure control and the adverse effects of administering an IV loading dose of phenytoin by constant infusion pump."2.67Phenytoin administration by constant intravenous infusion: selective rates of administration. ( Cline, D; Donovan, PJ, 1991)
"Phenytoin is an established drug in the treatment of acute repetitive seizures and status epilepticus."2.53Cardiovascular adverse effects of phenytoin. ( Guldiken, B; Noachtar, S; Rémi, J, 2016)
"Harmine is a β-carboline alkaloid that displays antidepressant, antitumor and other pharmacological effects."1.62Central inhibition prevents the in vivo acute toxicity of harmine in mice. ( Gao, S; Li, J; Li, X; Liang, H; Lv, Y; Tang, X; Wang, M; Xiao, L; Zhang, J; Zou, H, 2021)
"Twenty-nine complications were burning pain at the IV site, and 36 were related to excessive total dose of phenytoin and resultant drug intoxication."1.27Complications of intravenous phenytoin for acute treatment of seizures. Recommendations for usage. ( Drury, LR; Earnest, MP; Marx, JA, 1983)
"Phenytoin plasma levels were measured by gas chromatography for up to 48 hours after dosing."1.26Phenytoin toxicity and blood levels after a large oral dose. ( Evens, RP; Fraser, DG; Ludden, TM; Sutherland, EW, 1980)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199012 (66.67)18.7374
1990's3 (16.67)18.2507
2000's0 (0.00)29.6817
2010's2 (11.11)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Lv, Y1
Liang, H1
Li, J1
Li, X1
Tang, X1
Gao, S1
Zou, H1
Zhang, J1
Wang, M1
Xiao, L1
Guldiken, B1
Rémi, J1
Noachtar, S1
Vivanco-Hidalgo, RM1
Gomez, A1
Moreira, A1
Díez, L1
Elosua, R1
Roquer, J1
Harned, HS1
Mack, RB1
Earnest, MP1
Marx, JA1
Drury, LR1
Drake, CE1
Evens, RP1
Fraser, DG1
Ludden, TM1
Sutherland, EW1
Quinn, MJ1
Fitzgerald, DJ1
Deglin, SM1
Deglin, JM1
Chung, EK1
Ziegler, DK1
Meran, A1
Pfaltz, CR1
Donovan, PJ1
Cline, D1
Wyte, CD1
Berk, WA1
Spengler, RF1
Arrowsmith, JB1
Kilarski, DJ1
Buchanan, C1
Von Behren, L1
Graham, DR1
Muuronen, A1
Kaste, M1
Nikkilä, EA1
Tolppanen, EM1
Raisfeld, IH1

Reviews

6 reviews available for phenytoin and Cardiovascular Diseases

ArticleYear
Cardiovascular adverse effects of phenytoin.
    Journal of neurology, 2016, Volume: 263, Issue:5

    Topics: Anticonvulsants; Cardiovascular Diseases; Cardiovascular System; Humans; Phenytoin

2016
Cardiovascular problems of the newborn and their etiologies.
    Progress in clinical and biological research, 1983, Volume: 140

    Topics: Amphetamines; Animals; Cardiovascular Diseases; Estrogens; Ethanol; Female; Fetal Hypoxia; Heart Def

1983
Ticlopidine and clopidogrel.
    Circulation, 1999, Oct-12, Volume: 100, Issue:15

    Topics: Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Angina, Unstable; Aspirin; Bo

1999
Drug-induced cardiovascular diseases.
    Drugs, 1977, Volume: 14, Issue:1

    Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antidepressive Agents, Tricyclic; Antihypertensive A

1977
Toxicity to the nervous system of diphenylhydantoin: a review.
    International journal of neurology, 1978, Volume: 11, Issue:4

    Topics: Adrenal Cortex Hormones; Animals; Cardiovascular Diseases; Cerebellar Ataxia; Cerebellar Diseases; C

1978
Clinical pharmacology of drug interactions.
    Annual review of medicine, 1973, Volume: 24

    Topics: Antihypertensive Agents; Blood Coagulation Disorders; Cardiovascular Diseases; Coumarins; Drug Inter

1973

Trials

1 trial available for phenytoin and Cardiovascular Diseases

ArticleYear
Phenytoin administration by constant intravenous infusion: selective rates of administration.
    Annals of emergency medicine, 1991, Volume: 20, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Arteriosclerosis; Blood Pressure; Cardiovascular Diseases; Female; H

1991

Other Studies

11 other studies available for phenytoin and Cardiovascular Diseases

ArticleYear
Central inhibition prevents the in vivo acute toxicity of harmine in mice.
    The Journal of toxicological sciences, 2021, Volume: 46, Issue:6

    Topics: Acetylcholinesterase; Anesthetics; Animals; Cardiovascular Diseases; Central Nervous System Diseases

2021
Prevalence of cardiovascular risk factors in people with epilepsy.
    Brain and behavior, 2017, Volume: 7, Issue:2

    Topics: Adult; Aged; Anticonvulsants; Cardiovascular Diseases; Comorbidity; Dyslipidemias; Epilepsy; Female;

2017
Medical exorcism--acute dilantin intoxication.
    North Carolina medical journal, 1984, Volume: 45, Issue:2

    Topics: Cardiovascular Diseases; Epilepsy; Humans; Kinetics; Nystagmus, Pathologic; Phenytoin

1984
Cardiovascular complications of TCA overdose.
    The Journal of emergency medicine, 1984, Volume: 1, Issue:5

    Topics: Antidepressive Agents, Tricyclic; Bretylium Tosylate; Cardiovascular Diseases; Dobutamine; Humans; P

1984
Complications of intravenous phenytoin for acute treatment of seizures. Recommendations for usage.
    JAMA, 1983, Feb-11, Volume: 249, Issue:6

    Topics: Adolescent; Adult; Aged; Cardiovascular Diseases; Crystallization; Female; Humans; Infusions, Parent

1983
Cardiac drug overdose.
    American family physician, 1982, Volume: 25, Issue:1

    Topics: Arrhythmias, Cardiac; Bretylium Compounds; Cardiovascular Agents; Cardiovascular Diseases; Digoxin;

1982
Phenytoin toxicity and blood levels after a large oral dose.
    American journal of hospital pharmacy, 1980, Volume: 37, Issue:2

    Topics: Adult; Blood Proteins; Cardiovascular Diseases; Gastrointestinal Diseases; Humans; Kinetics; Male; N

1980
[The acute vestibular paralysis (author's transl)].
    Archives of oto-rhino-laryngology, 1975, Jul-08, Volume: 209, Issue:3

    Topics: Adolescent; Adult; Aged; Amphetamines; Audiometry; Bacterial Infections; Cardiovascular Diseases; Ch

1975
Severe oral phenytoin overdose does not cause cardiovascular morbidity.
    Annals of emergency medicine, 1991, Volume: 20, Issue:5

    Topics: Administration, Oral; Adult; Cardiovascular Diseases; Drug Overdose; Electrocardiography; Female; He

1991
Severe soft-tissue injury following intravenous infusion of phenytoin. Patient and drug administration risk factors.
    Archives of internal medicine, 1988, Volume: 148, Issue:6

    Topics: Age Factors; Aged; Cardiovascular Diseases; Catheterization; Connective Tissue Diseases; Edema; Fema

1988
Mortality from ischaemic heart disease among patients using anticonvulsive drugs: a case-control study.
    British medical journal (Clinical research ed.), 1985, Nov-23, Volume: 291, Issue:6507

    Topics: Aged; Anticonvulsants; Barbiturates; Carbamazepine; Cardiovascular Diseases; Cerebrovascular Disorde

1985