phenytoin has been researched along with Breast Cancer in 23 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case of erythema multiforme associated with prophylactic use of phenytoin during cranial radiation therapy is reported." | 7.74 | Erythema multiforme associated with prophylactic use of phenytoin during cranial radiation therapy. ( Barbosa, LA; Teixeira, CR, 2008) |
| "Phenytoin has been explored in over 100 different disorders; the last two promising indications tested in the clinic are breast cancer and optic neuritis." | 6.55 | Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action. ( Keppel Hesselink, JM; Kopsky, DJ, 2017) |
| "Doxorubicin (DOX) is an effective anticancer agent, but adverse cardiotoxic effects limit its use." | 5.43 | Cardioprotective Effect of Phenytoin on Doxorubicin-induced Cardiac Toxicity in a Rat Model. ( Asadnasab, G; Ashrafi Helan, J; Azarmi, Y; Babaei, H; Mohajjel Nayebi, A; Razmaraii, N, 2016) |
| "Tamoxifen is a prodrug, requiring cytochrome P450 enzyme-mediated metabolism to form the active metabolite endoxifen." | 5.40 | Profound reduction in the tamoxifen active metabolite endoxifen in a patient on phenytoin for epilepsy compared with a CYP2D6 genotype matched cohort. ( Gryn, SE; Kim, RB; Teft, WA, 2014) |
| "Three recent publications have reported the development of erythema multiforme and Stevens-Johnson syndrome in patients receiving cranial irradiation and sodium phenytoin." | 4.79 | Is phenytoin contraindicated in patients receiving cranial irradiation? ( Borg, MF; Probert, JC; Zwi, LJ, 1995) |
| "We report the cases of 2 breast cancer patients who received capecitabine(CAP)and concomitant anticonvulsant therapy with either phenytoin(PHT)or valproate(VPA)for brain metastasis." | 3.80 | [Effect of capecitabine therapy on the blood levels of antiepileptic drugs - report of two cases]. ( Ibayashi, Y; Jotoku, H; Takahashi, M; Takasaki, M; Tanaka, H; Watanabe, K, 2014) |
| "Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been associated with some drugs, particularly anticonvulsants such as phenytoin." | 3.74 | [Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy]. ( Fernández, FA; Garcés, FJ; Pintor, E; Quesada, R, 2007) |
| "A case of erythema multiforme associated with prophylactic use of phenytoin during cranial radiation therapy is reported." | 3.74 | Erythema multiforme associated with prophylactic use of phenytoin during cranial radiation therapy. ( Barbosa, LA; Teixeira, CR, 2008) |
| " The aim of the study was to investigate the influence of the antiepileptic drugs PHT, PB, VPA and lamotrigine (LTG) on estrogen-stimulated cell growth of human breast cancer cells (MCF-7), and to evaluate whether this effect could be related to a direct estrogen receptor (ER) binding." | 3.72 | Antiepileptic drugs inhibit cell growth in the human breast cancer cell line MCF7. ( Meussen-Elholm, ET; Olsen, CM; Røste, LS; Taubøll, E, 2004) |
| " The extensive involvement of the oral mucosa with conjunctivitis and synechiae of the eyelids, facial swelling, and extension of the rash over the trunk and shoulders with bullous detachment of less than 10% of the total body surface strongly suggested Stevens-Johnson syndrome caused by phenytoin treatment in our patient." | 3.71 | Stevens-Johnson syndrome in a patient receiving anticonvulsant therapy during cranial irradiation. ( Aydiner, A; Eralp, Y; Saip, P; Taş, F; Topuz, E, 2001) |
| "Phenytoin has been explored in over 100 different disorders; the last two promising indications tested in the clinic are breast cancer and optic neuritis." | 2.55 | Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action. ( Keppel Hesselink, JM; Kopsky, DJ, 2017) |
| "Doxorubicin (DOX) is an effective anticancer agent, but adverse cardiotoxic effects limit its use." | 1.43 | Cardioprotective Effect of Phenytoin on Doxorubicin-induced Cardiac Toxicity in a Rat Model. ( Asadnasab, G; Ashrafi Helan, J; Azarmi, Y; Babaei, H; Mohajjel Nayebi, A; Razmaraii, N, 2016) |
| "Treatment with phenytoin, at a dose equivalent to that used to treat epilepsy (60 mg/kg; daily), significantly reduced tumour growth, without affecting animal weight." | 1.42 | The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. ( Brackenbury, WJ; Dowle, AA; Nelson, M; Thomas, JR; Yang, M, 2015) |
| "Tamoxifen is a prodrug, requiring cytochrome P450 enzyme-mediated metabolism to form the active metabolite endoxifen." | 1.40 | Profound reduction in the tamoxifen active metabolite endoxifen in a patient on phenytoin for epilepsy compared with a CYP2D6 genotype matched cohort. ( Gryn, SE; Kim, RB; Teft, WA, 2014) |
| "Phenytoin levels were subjected to analysis of variance and the dose effect was approached using a multiple comparison test." | 1.37 | Capecitabine-phenytoin interaction is dose dependent with an unexpected time course. ( de Los Ríos la Rosa, F; Privitera, M, 2011) |
| " The plasma cyclophosphamide disposition data of these patients were fit by a one-compartment pharmacokinetic model, in which the decline of plasma cyclophosphamide concentration after reaching the initial steady state was modeled as being due to an increase in the clearance rate of cyclophosphamide." | 1.29 | Nonlinear pharmacokinetics of cyclophosphamide in patients with metastatic breast cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation. ( Black, KC; Chen, TL; Colvin, OM; Grochow, LB; Kennedy, MJ; Noe, DA; Passos-Coelho, JL, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.70) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 10 (43.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tanaka, H | 1 |
| Jotoku, H | 1 |
| Takasaki, M | 1 |
| Ibayashi, Y | 1 |
| Watanabe, K | 1 |
| Takahashi, M | 1 |
| Gryn, SE | 1 |
| Teft, WA | 1 |
| Kim, RB | 1 |
| Nelson, M | 1 |
| Yang, M | 3 |
| Dowle, AA | 1 |
| Thomas, JR | 1 |
| Brackenbury, WJ | 3 |
| Aktas, CC | 1 |
| Zeybek, ND | 1 |
| Piskin, AK | 1 |
| Razmaraii, N | 1 |
| Babaei, H | 1 |
| Mohajjel Nayebi, A | 1 |
| Asadnasab, G | 1 |
| Ashrafi Helan, J | 1 |
| Azarmi, Y | 1 |
| Mohammed, FH | 1 |
| Khajah, MA | 1 |
| Luqmani, YA | 1 |
| Keppel Hesselink, JM | 1 |
| Kopsky, DJ | 1 |
| Goyal, S | 1 |
| Biswas, A | 1 |
| Puri, T | 1 |
| Mohanti, BK | 1 |
| Privitera, M | 1 |
| de Los Ríos la Rosa, F | 1 |
| Kozminski, DJ | 1 |
| Wold, LA | 1 |
| Modak, R | 1 |
| Calhoun, JD | 1 |
| Isom, LL | 1 |
| Brickell, K | 1 |
| Porter, D | 1 |
| Thompson, P | 1 |
| Naik, AM | 1 |
| Joseph, K | 1 |
| Harris, M | 1 |
| Davis, C | 1 |
| Shapiro, R | 1 |
| Hiotis, KL | 1 |
| Olsen, CM | 1 |
| Meussen-Elholm, ET | 1 |
| Røste, LS | 1 |
| Taubøll, E | 1 |
| Curigliano, G | 1 |
| Formica, V | 1 |
| De Pas, T | 1 |
| Spitaleri, G | 1 |
| Pietri, E | 1 |
| Fazio, N | 1 |
| de Braud, F | 1 |
| Goldhirsch, A | 1 |
| Bajwah, S | 1 |
| Fernández, FA | 1 |
| Pintor, E | 1 |
| Quesada, R | 1 |
| Garcés, FJ | 1 |
| Barbosa, LA | 1 |
| Teixeira, CR | 1 |
| Borg, MF | 1 |
| Probert, JC | 1 |
| Zwi, LJ | 1 |
| Chen, TL | 1 |
| Passos-Coelho, JL | 1 |
| Noe, DA | 1 |
| Kennedy, MJ | 1 |
| Black, KC | 1 |
| Colvin, OM | 1 |
| Grochow, LB | 1 |
| Mishriki, YY | 1 |
| Eralp, Y | 1 |
| Aydiner, A | 1 |
| Taş, F | 1 |
| Saip, P | 1 |
| Topuz, E | 1 |
| Dil'man, VM | 2 |
| Bershteĭn, LM | 1 |
| Tsyrlina, EV | 2 |
| Bobrov, IuF | 1 |
| Kovaleva, IG | 1 |
| Eliubaeva, GO | 1 |
| Vishnevskiĭ, AS | 1 |
| Bulovskaia, LN | 1 |
2 reviews available for phenytoin and Breast Cancer
| Article | Year |
|---|---|
Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action.
Topics: Animals; Anticonvulsants; Antineoplastic Agents; Breast Neoplasms; Drug Discovery; Epilepsy; History | 2017 |
Is phenytoin contraindicated in patients receiving cranial irradiation?
Topics: Biopsy; Bone Neoplasms; Brain Neoplasms; Breast Neoplasms; Carcinoma; Combined Modality Therapy; Con | 1995 |
21 other studies available for phenytoin and Breast Cancer
| Article | Year |
|---|---|
[Effect of capecitabine therapy on the blood levels of antiepileptic drugs - report of two cases].
Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Brain Neoplasms; Breast Neoplasms; Capecitabine; D | 2014 |
Profound reduction in the tamoxifen active metabolite endoxifen in a patient on phenytoin for epilepsy compared with a CYP2D6 genotype matched cohort.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Cohort Studies; Cytochrome P-450 CYP2D6; Drug Inte | 2014 |
The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis.
Topics: Animals; Anticonvulsants; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell | 2015 |
In vitro effects of phenytoin and DAPT on MDA-MB-231 breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dipeptides; Drug Interactions; Female; Human | 2015 |
Cardioprotective Effect of Phenytoin on Doxorubicin-induced Cardiac Toxicity in a Rat Model.
Topics: Animals; Breast Neoplasms; Cardiomyopathies; Cardiotoxicity; Cytoprotection; Disease Models, Animal; | 2016 |
Blockade of voltage-gated sodium channels inhibits invasion of endocrine-resistant breast cancer cells.
Topics: Breast Neoplasms; Cell Movement; Cell Proliferation; Estrogen Receptor alpha; Female; Gene Expressio | 2016 |
Stevens-Johnson syndrome following concurrent phenytoin and holocranial radiotherapy.
Topics: Anti-Inflammatory Agents; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Brain Neo | 2010 |
Capecitabine-phenytoin interaction is dose dependent with an unexpected time course.
Topics: Aged; Anticonvulsants; Antineoplastic Agents; Breast Neoplasms; Capecitabine; Deoxycytidine; Dose-Re | 2011 |
Therapeutic potential for phenytoin: targeting Na(v)1.5 sodium channels to reduce migration and invasion in metastatic breast cancer.
Topics: Antineoplastic Agents; Area Under Curve; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line, Tum | 2012 |
Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports.
Topics: Adenocarcinoma; Administration, Oral; Aged; Anticonvulsants; Antimetabolites, Antineoplastic; Breast | 2003 |
Indigent breast cancer patients among all racial and ethnic groups present with more advanced disease compared with nationally reported data.
Topics: Breast Neoplasms; Ethnicity; Female; Humans; Insurance, Health; Medical Indigency; New York City; Ph | 2003 |
Antiepileptic drugs inhibit cell growth in the human breast cancer cell line MCF7.
Topics: Anticonvulsants; Breast Neoplasms; Cell Division; Cell Line, Tumor; Drug Screening Assays, Antitumor | 2004 |
Life-threatening toxic epidermal necrolysis during voriconazole therapy for invasive aspergillosis after chemotherapy.
Topics: Adult; Anticonvulsants; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Aspergill | 2006 |
Management of phenytoin toxicity in palliative care.
Topics: Anticonvulsants; Bone Neoplasms; Breast Neoplasms; Female; Humans; Palliative Care; Phenytoin; Seizu | 2007 |
[Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy].
Topics: Adenocarcinoma; Aged; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Combined Modality Therapy; | 2007 |
Erythema multiforme associated with prophylactic use of phenytoin during cranial radiation therapy.
Topics: Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cranial | 2008 |
Nonlinear pharmacokinetics of cyclophosphamide in patients with metastatic breast cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms | 1995 |
The case of the dire desquamation. Stevens-Johnson syndrome.
Topics: Aged; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Cranial Irradiation; Fatal Outcome; Female | 1998 |
Stevens-Johnson syndrome in a patient receiving anticonvulsant therapy during cranial irradiation.
Topics: Adult; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Carcinoma, Ductal, Breast; Cranial Irradi | 2001 |
[Correction of endocrine-metabolic disorders in oncologic patients. The effect of biguanides (phenformin and adebita), miskleron and diphenin].
Topics: Adrenal Cortex Hormones; Aged; Biguanides; Blood Glucose; Body Weight; Breast Neoplasms; Buformin; C | 1975 |
[Justification of the use of diphenine (diphenylhydantoin) in oncologic practice].
Topics: Adult; Breast Neoplasms; Female; Fibroma; Genital Neoplasms, Female; Humans; Middle Aged; Ovarian Cy | 1971 |