phenytoin has been researched along with Bone Loss, Osteoclastic in 22 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Levetiracetam treatment did not affect bone strength, bone mass, and bone turnover." | 1.46 | Effects of the Antiepileptic Drugs Phenytoin, Gabapentin, and Levetiracetam on Bone Strength, Bone Mass, and Bone Turnover in Rats. ( Izumo, N; Kanda, J; Kobayashi, Y; Onodera, K; Shimakura, T; Takahashi, HE; Wakabayashi, H; Yamamoto, N, 2017) |
| "DPH concealed LPS-induced bone resorption in mouse calvarial organ cultures and inhibited the pit-forming activity of mouse osteoclasts cultured on dentine slices." | 1.35 | Diphenylhydantoin inhibits osteoclast differentiation and function through suppression of NFATc1 signaling. ( Kinugawa, S; Kobayashi, Y; Koide, M; Maeda, K; Mizoguchi, T; Nakamura, H; Ninomiya, T; Takahashi, N; Udagawa, N; Yamashita, T; Yasuda, H, 2009) |
| "Markers of bone formation and bone resorption were determined in serum and urine." | 1.31 | Long-term anticonvulsant therapy leads to low bone mineral density--evidence for direct drug effects of phenytoin and carbamazepine on human osteoblast-like cells. ( Becker, A; Feldkamp, J; Scharff, D; Scherbaum, WA; Witte, OW, 2000) |
| "The effect of heparin on osteoclastic bone resorption was studied in vitro using the disaggregated osteoclast resorption assay." | 1.28 | Effects of heparin on osteoclast activity. ( Chowdhury, MH; Dempster, DW; Hamada, C, 1992) |
| "The % of gingival hyperplasia was significantly higher (P less than 0." | 1.27 | The effects of phenytoin and sodium valproate on the periodontal health of adult epileptic patients. ( Seymour, RA; Smith, DG; Turnbull, DN, 1985) |
| "When bone resorption was stimulated by prostaglandin E2, DPH (50 micrograms/ml) also reduced the mobilization of bone mineral and the release of beta-glucuronidase without influencing the release of lactate dehydrogenase." | 1.26 | Influence of diphenylhydantoin on lysosomal enzyme release during bone resorption in vitro. ( Hänström, L; Lerner, U, 1980) |
| "A depressive effect on bone resorption was found involving radioactive calcium as well as tritiated proline." | 1.26 | Influence of diphenylhydantoin on isotope release and bone enzymes in vitro. ( Lund, B; Pedersen, JG; Reimann, I, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (68.18) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 3 (13.64) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kanda, J | 1 |
| Izumo, N | 1 |
| Kobayashi, Y | 2 |
| Onodera, K | 2 |
| Shimakura, T | 1 |
| Yamamoto, N | 1 |
| Takahashi, HE | 1 |
| Wakabayashi, H | 1 |
| Koide, M | 1 |
| Kinugawa, S | 1 |
| Ninomiya, T | 1 |
| Mizoguchi, T | 1 |
| Yamashita, T | 1 |
| Maeda, K | 1 |
| Yasuda, H | 1 |
| Nakamura, H | 1 |
| Takahashi, N | 1 |
| Udagawa, N | 1 |
| Staple, PH | 1 |
| Houck, JC | 1 |
| Nutter, DJ | 1 |
| Hahn, TJ | 2 |
| DeBartolo, TF | 1 |
| Halstead, LR | 2 |
| Lerner, U | 2 |
| Hänström, L | 2 |
| Pedersen, JG | 1 |
| Lund, B | 1 |
| Reimann, I | 1 |
| Rifkin, BR | 2 |
| Baker, RL | 1 |
| Somerman, MJ | 2 |
| Pointon, SE | 1 |
| Coleman, SJ | 1 |
| Au, WY | 2 |
| Välimäki, MJ | 1 |
| Tiihonen, M | 1 |
| Laitinen, K | 1 |
| Tähtelä, R | 1 |
| Kärkkäinen, M | 1 |
| Lamberg-Allardt, C | 1 |
| Mäkelä, P | 1 |
| Tunninen, R | 1 |
| Ciancio, SG | 1 |
| Feldkamp, J | 1 |
| Becker, A | 1 |
| Witte, OW | 1 |
| Scharff, D | 1 |
| Scherbaum, WA | 1 |
| Takahashi, A | 1 |
| Shinoda, H | 1 |
| Mayanagi, H | 1 |
| Johnell, O | 1 |
| Nilsson, BE | 1 |
| Wallöe, A | 1 |
| Wiklund, PE | 1 |
| Scharp, CR | 1 |
| Richardson, CA | 1 |
| Kahn, AJ | 1 |
| Teitelbaum, SL | 1 |
| Fehlinger, R | 1 |
| Seidel, K | 1 |
| Chowdhury, MH | 1 |
| Hamada, C | 1 |
| Dempster, DW | 1 |
| Fredholm, BB | 1 |
| Pointon-Miska, S | 1 |
| Seymour, RA | 1 |
| Smith, DG | 1 |
| Turnbull, DN | 1 |
| Jenkins, MV | 2 |
| Harris, M | 3 |
| Wills, MR | 2 |
| Goldhaber, P | 1 |
| Glickman, I | 1 |
3 reviews available for phenytoin and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Medications as risk factors for periodontal disease.
Topics: Aging; Alveolar Process; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvuls | 1996 |
[Critical remarks on the concept of "osteopathia antiepileptica"].
Topics: Anticonvulsants; Bone Resorption; Calcium; Epilepsy; Humans; Osteomalacia; Phenytoin; Tetany; Vitami | 1976 |
Periodontal disease.
Topics: Adult; Ascorbic Acid Deficiency; Bone Resorption; Child; Dental Deposits; Dental Plaque; Endotoxins; | 1971 |
19 other studies available for phenytoin and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Effects of the Antiepileptic Drugs Phenytoin, Gabapentin, and Levetiracetam on Bone Strength, Bone Mass, and Bone Turnover in Rats.
Topics: Administration, Oral; Amines; Animals; Anticonvulsants; Bone Density; Bone Remodeling; Bone Resorpti | 2017 |
Diphenylhydantoin inhibits osteoclast differentiation and function through suppression of NFATc1 signaling.
Topics: Animals; Animals, Newborn; Base Sequence; Bone Resorption; Cell Differentiation; Cells, Cultured; DN | 2009 |
Absence of characteristic reactions in the periodontium and other peripheral tissues of hamsters showing neurophysiologic response to chronic administration of 5,5-diphenylhydantoin (dilantin).
Topics: Adrenal Glands; Alveolar Process; Animals; Body Weight; Bone Resorption; Cricetinae; Female; Gingiva | 1967 |
Ouabain effects on hormonally-stimulated bone resorption and cyclic AMP content in cultured fetal rat bones.
Topics: Animals; Bone Resorption; Calcimycin; Calcitriol; Calcium; Cells, Cultured; Cyclic AMP; Dihydroxycho | 1980 |
Influence of diphenylhydantoin on lysosomal enzyme release during bone resorption in vitro.
Topics: Animals; beta-Galactosidase; Bone and Bones; Bone Resorption; Calcium; Galactosidases; Glucuronidase | 1980 |
Influence of diphenylhydantoin on isotope release and bone enzymes in vitro.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Bone and Bones; Bone Resorption; Calcium; Calcium R | 1982 |
Osteoid resorption by mononuclear cells in vitro.
Topics: Animals; Bone Matrix; Bone Resorption; Calcitonin; Dihydroxycholecalciferols; Macrophages; Organ Cul | 1980 |
Bone mineral density measured by dual-energy x-ray absorptiometry and novel markers of bone formation and resorption in patients on antiepileptic drugs.
Topics: Absorptiometry, Photon; Adult; Alkaline Phosphatase; Bone Density; Bone Development; Bone Resorption | 1994 |
Long-term anticonvulsant therapy leads to low bone mineral density--evidence for direct drug effects of phenytoin and carbamazepine on human osteoblast-like cells.
Topics: Absorptiometry, Photon; Adult; Amino Acids; Anticonvulsants; Bone Density; Bone Resorption; Carbamaz | 2000 |
Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria.
Topics: Animals; Bone Resorption; Mice; Organ Culture Techniques; Phenytoin; Skull | 2000 |
Bone morphology in epileptics.
Topics: Adult; Aged; Bone and Bones; Bone Diseases; Bone Resorption; Epilepsy; Female; Humans; Male; Middle | 1979 |
Interaction of diphenylhydantoin (phenytoin) and phenobarbital with hormonal mediation of fetal rat bone resorption in vitro.
Topics: Animals; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Cyclic AMP; Dihydroxycholecalciferols | 1978 |
Effects of heparin on osteoclast activity.
Topics: Animals; Bone Resorption; Cells, Cultured; Chickens; Chondroitin Sulfates; Culture Media; Cyclospori | 1992 |
Diphenylhydantoin inhibits parathyroid hormone and prostaglandin E2-stimulated bone resorption in mouse calvaria without affecting cyclic AMP formation.
Topics: Animals; Bone Resorption; Calcium; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Glyco | 1985 |
Effect of phenytoin on rat bone resorption in vitro.
Topics: Animals; Bone Resorption; Calcitriol; Organ Culture Techniques; Parathyroid Hormone; Phenytoin; Rats | 1986 |
The effects of phenytoin and sodium valproate on the periodontal health of adult epileptic patients.
Topics: Adolescent; Adult; Aged; Alveolar Process; Bone Resorption; Cross-Sectional Studies; Dental Plaque I | 1985 |
The effect of phenytoin on parathyroid extract and 25-hydroxycholecalciferol-induced bone resorption: adenosine 3, 5 cyclic monophosphate production.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium; Calcium Radioisotopes; Cells, Cultured; Cyclic AM | 1974 |
Root abnormalities in epileptics and the inhibition of parathyroid hormone induced bone resorption by diphenyl hydantoin in tissue culture.
Topics: Adult; Animals; Bone Resorption; Culture Techniques; Epilepsy; Humans; Mice; Parathyroid Hormone; Pe | 1974 |
Phenytoin inhibition of parathyroid hormone induced bone resorption in vitro.
Topics: Animals; Bone Resorption; Calcium; Calcium Radioisotopes; Culture Media; Culture Techniques; Hypocal | 1974 |