phenytoin has been researched along with Bone Fractures in 13 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenytoin has a beneficial effect on wound healing and on the healing of bone fractures, while beta-aminopropionitrile (BAPN) has an adverse effect on both." | 3.67 | Effect of phenytoin and/or beta-aminoproprionitrile on a surgically induced periosteal wound. ( Kuebel, MA; Taylor, JJ; Yeager, VL, 1985) |
| "Four cases of osteomalacia associated with the long term consumption of phenytoin (Dilantin) were admitted to a geriatric unit in a two-month period." | 3.65 | Anticonvulsant-induced osteomalacia. ( Palmer, KT; Smith, AE; Taylor, BB, 1977) |
| "Before epilepsy was diagnosed there was no difference in overall fracture rate between patients and controls (RR = 1." | 2.69 | Fracture risk is increased in epilepsy. ( Dam, M; Mosekilde, L; Rejnmark, L; Tigaran, C; Tigaran, S; Vestergaard, P, 1999) |
| "Levetiracetam treatment did not affect bone strength, bone mass, and bone turnover." | 1.46 | Effects of the Antiepileptic Drugs Phenytoin, Gabapentin, and Levetiracetam on Bone Strength, Bone Mass, and Bone Turnover in Rats. ( Izumo, N; Kanda, J; Kobayashi, Y; Onodera, K; Shimakura, T; Takahashi, HE; Wakabayashi, H; Yamamoto, N, 2017) |
| "Phenytoin use was associated with a statistically significant increased risk of fractures OR=1." | 1.37 | Association of antiepileptic drugs, vitamin D, and calcium supplementation with bone fracture occurrence in epilepsy patients. ( Abner, E; Espinosa, PS; Perez, DL; Ryan, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (61.54) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kanda, J | 1 |
| Izumo, N | 1 |
| Kobayashi, Y | 1 |
| Onodera, K | 1 |
| Shimakura, T | 1 |
| Yamamoto, N | 1 |
| Takahashi, HE | 1 |
| Wakabayashi, H | 1 |
| Espinosa, PS | 1 |
| Perez, DL | 1 |
| Abner, E | 1 |
| Ryan, M | 1 |
| Mathew, M | 1 |
| Dhillon, MS | 1 |
| Nagi, ON | 1 |
| Sen, RK | 1 |
| Nada, R | 1 |
| Vestergaard, P | 1 |
| Tigaran, S | 1 |
| Rejnmark, L | 1 |
| Tigaran, C | 1 |
| Dam, M | 1 |
| Mosekilde, L | 1 |
| Palmer, KT | 1 |
| Smith, AE | 1 |
| Taylor, BB | 1 |
| Lidgren, L | 1 |
| Wallöe, A | 1 |
| Frymoyer, JW | 1 |
| Altschuler, EM | 1 |
| Segal, R | 1 |
| Mirza, RA | 1 |
| Rath, S | 1 |
| Bal, V | 1 |
| Bhide, MB | 1 |
| Kuebel, MA | 1 |
| Yeager, VL | 1 |
| Taylor, JJ | 1 |
| Sotaniemi, EA | 1 |
| Hakkarainen, HK | 1 |
| Puranen, JA | 1 |
| Lahti, RO | 1 |
| Birch, AA | 1 |
| Mitchell, GD | 1 |
| Playford, GA | 1 |
| Lang, CA | 1 |
2 trials available for phenytoin and Bone Fractures
| Article | Year |
|---|---|
Fracture risk is increased in epilepsy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Biomechanical Phenomena; Epilepsy; Fema | 1999 |
Changes in serum potassium response to succinylcholine following trauma.
Topics: Burns; Carbon Dioxide; Fractures, Bone; Heart Arrest; Humans; Hyperkalemia; Injections, Intravenous; | 1969 |
11 other studies available for phenytoin and Bone Fractures
| Article | Year |
|---|---|
Effects of the Antiepileptic Drugs Phenytoin, Gabapentin, and Levetiracetam on Bone Strength, Bone Mass, and Bone Turnover in Rats.
Topics: Administration, Oral; Amines; Animals; Anticonvulsants; Bone Density; Bone Remodeling; Bone Resorpti | 2017 |
Association of antiepileptic drugs, vitamin D, and calcium supplementation with bone fracture occurrence in epilepsy patients.
Topics: Age Factors; Anticonvulsants; Calcium; Cohort Studies; Dietary Supplements; Epilepsy; Female; Fractu | 2011 |
The effect of local administration of phenytoin on fracture healing: an experimental study.
Topics: Animals; Bony Callus; Female; Fracture Healing; Fractures, Bone; Male; Phenytoin; Prospective Studie | 2006 |
Anticonvulsant-induced osteomalacia.
Topics: Animals; Chick Embryo; Dose-Response Relationship, Drug; Female; Fractures, Bone; Humans; Osteomalac | 1977 |
Incidence of fracture in epileptics.
Topics: Adult; Age Factors; Aged; Epilepsy; Female; Fractures, Bone; Humans; Male; Middle Aged; Osteomalacia | 1977 |
Fracture healing in rats treated with diphenylhydantoin (Dilantin).
Topics: Animals; Disease Models, Animal; Fibula; Fractures, Bone; Male; Phenytoin; Rats; Wound Healing | 1976 |
Generalized seizures following myelography with iohexol (Omnipaque).
Topics: Electromyography; Epilepsy, Generalized; Fractures, Bone; Humans; Humerus; Iohexol; Male; Middle Age | 1990 |
Accelerated callous formation with phenytoin sodium.
Topics: Adolescent; Adult; Bony Callus; Child; Child, Preschool; Fractures, Bone; Humans; Middle Aged; Pheny | 1987 |
Mineralisation in experimental fracture repair estimated by tetracycline deposition.
Topics: Animals; Bony Callus; Calcium; Fractures, Bone; Male; Phenytoin; Rats; Tetracycline; Wound Healing | 1986 |
Effect of phenytoin and/or beta-aminoproprionitrile on a surgically induced periosteal wound.
Topics: Administration, Oral; Aminopropionitrile; Animals; Body Weight; Cartilage; Fractures, Bone; Male; Pe | 1985 |
Radiologic bone changes and hypocalcemia with anticonvulsant therapy in epilepsy.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Back Pain; Calcium; Carbamazepine; D | 1972 |