phenytoin and Body Weight studies

Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Research Excerpts

Excerpt	Relevance	Reference
"The Established Status Epilepticus Treatment Trial was a blinded, comparative-effectiveness study of fosphenytoin, levetiracetam, and valproic acid in benzodiazepine-refractory status epilepticus."	9.34	The association of patient weight and dose of fosphenytoin, levetiracetam, and valproic acid with treatment success in status epilepticus. ( Bleck, TP; Chamberlain, JM; Cloyd, JC; Cock, HR; Coles, LD; Conwit, RA; Elm, JJ; Fountain, NB; Kapur, J; Lowenstein, DH; Sathe, AG; Shinnar, S; Silbergleit, R, 2020)
"Changes in body weight were evaluated in 349 patients from a study comparing efficacy of add-on therapy with tiagabine (TGB), carbamazepine (CBZ) or phenytoin (PHT)."	9.09	Total percentage body weight changes during add-on therapy with tiagabine, carbamazepine and phenytoin. ( Bertrand, ME; Deaton, RL; Hogan, RE; Sommerville, KW, 2000)
"The appropriate loading dose strategy for phenytoin/fosphenytoin in overweight patients is unknown."	8.12	Evaluation of phenytoin loading doses in overweight patients using actual versus adjusted body weight. ( Coppiano, LS; Keats, K; Powell, R; Rocker, J; Waller, J, 2022)
"The PPK model, using the power scaling of body weight, effectively elucidated the topiramate serum concentration profile ranging from pediatric to adult patients."	7.85	Population Pharmacokinetics of Topiramate in Japanese Pediatric and Adult Patients With Epilepsy Using Routinely Monitored Data. ( Ikeda, A; Ito, S; Matsubara, K; Sugimoto, M; Takeuchi, M; Yamamoto, S; Yano, I; Yonezawa, A, 2017)
"There are many reports that the teratogenic effects of phenytoin, especially cleft palate can be decreased by stimulation of maternal immune system."	7.73	A comparison study of effects of Echinacea extract and levamisole on phenytoin-induced cleft palate in mice. ( Arzi, A; Khaksary Mahabady, M; Najafzadeh, H; Papahn, AA; Ranjbar, R, 2006)
" Chronic hypoxia was induced pharmacologically by the administration of the anticonvulsant phenytoin (PHT) during the entire period of pregnancy."	7.72	Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration. ( Brucknerová, I; Dubovický, M; Juránek, I; Mach, M; Navarová, J; Soltés, L; Ujházy, E; Zeman, M, 2004)
"Serum phenytoin concentrations were investigated in 109 serum samples from 21 patients with the acquired immunodeficiency syndrome (AIDS) and in 1,231 serum samples from 557 control subjects during phenytoin therapy."	7.69	Therapeutic drug monitoring of phenytoin in patients with the acquired immunodeficiency syndrome. ( Beijnen, JH; Bult, A; Burger, DM; Koks, CH; Kraaijeveld, CL; Meenhorst, PL; Mulder, JW, 1994)
"This study was undertaken to determine the incidence of endotracheal intubation after the use of diazepam compared with phenobarbital or phenytoin in emergency treatment of seizures in children."	7.68	Diazepam and intubation in emergency treatment of seizures in children. ( Dimand, RJ; Karr, VA; Kennedy, KJ; Orr, RA; Venkataraman, ST, 1991)
"Heavy male Sprague-Dawley rats die of ventricular fibrillation within 2 to 3 h after isoproterenol administration."	7.67	Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death. ( Balazs, T; Ehrreich, SJ; el-Hage, AN; Johnson, GL, 1986)
"Analysis of plasma phenytoin in a group of patients treated for epilepsy showed that only 36% had values in the therapeutic range."	7.66	Prediction of phenytoin dosage in epilepsy using multiple linear regression. ( Gray, SP, 1982)
"A survey was carried out into the degree of gingival hyperplasia in 68 patients receiving phenytoin in a hospital for the mentally handicapped."	7.66	Risk factors in phenytoin-induced gingival hyperplasia. ( Addy, V; Campbell, N; D'Arcy, PF; Eyre, DG; McElnay, JC, 1983)
" Simulation results showed that the dosing interval should be reduced to achieve optimal dosing in neonates and infants, and the optimal dose required increases with weight."	5.51	Optimal Dosing Regimen of Phenytoin for Korean Epilepsy Patients: From Premature Babies to the Elderly. ( Chae, D; Guk, J; Kim, JH; Lee, SG; Park, K, 2019)
"The Established Status Epilepticus Treatment Trial was a blinded, comparative-effectiveness study of fosphenytoin, levetiracetam, and valproic acid in benzodiazepine-refractory status epilepticus."	5.34	The association of patient weight and dose of fosphenytoin, levetiracetam, and valproic acid with treatment success in status epilepticus. ( Bleck, TP; Chamberlain, JM; Cloyd, JC; Cock, HR; Coles, LD; Conwit, RA; Elm, JJ; Fountain, NB; Kapur, J; Lowenstein, DH; Sathe, AG; Shinnar, S; Silbergleit, R, 2020)
" BSA would serve as a practical alternative to LW for scaling adult dosage of metabolically eliminated drugs to children."	5.31	Developmental changes in the liver weight- and body weight-normalized clearance of theophylline, phenytoin and cyclosporine in children. ( Echizen, H; Kanamori, M; Takahashi, H, 2002)
" When clinically indicated the daily dosage rate was adjusted by 50 mg steps until a serum concentration of 10--20 mg/l was produced."	5.26	Individual variation in daily dosage requirements for phenytoin sodium in patients with epilepsy. ( Barot, MH; Grant, RH; Maheendran, KK; Mawer, GE; Woodcock, BG, 1978)
"Carbamazepine clearance was not associated with body weight or any parameterization of body size nor was age or race or any marker of hepatic or renal function in community dwelling elderly patients."	5.16	Population pharmacokinetics of carbamazepine in elderly patients. ( Birnbaum, AK; Brundage, RC; Collins, JF; Macias, FM; Punyawudho, B; Ramsay, ER, 2012)
"Changes in body weight were evaluated in 349 patients from a study comparing efficacy of add-on therapy with tiagabine (TGB), carbamazepine (CBZ) or phenytoin (PHT)."	5.09	Total percentage body weight changes during add-on therapy with tiagabine, carbamazepine and phenytoin. ( Bertrand, ME; Deaton, RL; Hogan, RE; Sommerville, KW, 2000)
"The PPK model, using the power scaling of body weight, effectively elucidated the topiramate serum concentration profile ranging from pediatric to adult patients."	3.85	Population Pharmacokinetics of Topiramate in Japanese Pediatric and Adult Patients With Epilepsy Using Routinely Monitored Data. ( Ikeda, A; Ito, S; Matsubara, K; Sugimoto, M; Takeuchi, M; Yamamoto, S; Yano, I; Yonezawa, A, 2017)
"Preliminary clinical trials have recently shown that phenytoin, an antiepileptic drug, may also be beneficial for treatment of bipolar disorder."	3.76	Effect of prolonged phenytoin administration on rat brain gene expression assessed by DNA microarrays. ( Agam, G; Amar, S; Belmaker, RH; Conte, A; Mariotti, V; Melissari, E; Pellegrini, S, 2010)
"There are many reports that the teratogenic effects of phenytoin, especially cleft palate can be decreased by stimulation of maternal immune system."	3.73	A comparison study of effects of Echinacea extract and levamisole on phenytoin-induced cleft palate in mice. ( Arzi, A; Khaksary Mahabady, M; Najafzadeh, H; Papahn, AA; Ranjbar, R, 2006)
" Chronic hypoxia was induced pharmacologically by the administration of the anticonvulsant phenytoin (PHT) during the entire period of pregnancy."	3.72	Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration. ( Brucknerová, I; Dubovický, M; Juránek, I; Mach, M; Navarová, J; Soltés, L; Ujházy, E; Zeman, M, 2004)
"Serum phenytoin concentrations were investigated in 109 serum samples from 21 patients with the acquired immunodeficiency syndrome (AIDS) and in 1,231 serum samples from 557 control subjects during phenytoin therapy."	3.69	Therapeutic drug monitoring of phenytoin in patients with the acquired immunodeficiency syndrome. ( Beijnen, JH; Bult, A; Burger, DM; Koks, CH; Kraaijeveld, CL; Meenhorst, PL; Mulder, JW, 1994)
" The stress-induced CA3 apical dendritic atrophy in subordinates was prevented by administering daily oral doses of the antiepileptic drug phenytoin (Dilantin, Sigma, St."	3.69	Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. ( Flügge, G; Fuchs, E; Magariños, AM; McEwen, BS, 1996)
"This study was undertaken to determine the incidence of endotracheal intubation after the use of diazepam compared with phenobarbital or phenytoin in emergency treatment of seizures in children."	3.68	Diazepam and intubation in emergency treatment of seizures in children. ( Dimand, RJ; Karr, VA; Kennedy, KJ; Orr, RA; Venkataraman, ST, 1991)
"Heavy male Sprague-Dawley rats die of ventricular fibrillation within 2 to 3 h after isoproterenol administration."	3.67	Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death. ( Balazs, T; Ehrreich, SJ; el-Hage, AN; Johnson, GL, 1986)
"Steady-state serum concentrations of phenytoin and phenobarbital were obtained in 70 epileptic patients in Taiwan and evaluated with respect to age, sex, and body weight."	3.67	Steady-state serum levels of anticonvulsant drugs in Chinese epileptic patients living in Taiwan. ( Lai, ML, 1985)
"Phenytoin has a beneficial effect on wound healing and on the healing of bone fractures, while beta-aminopropionitrile (BAPN) has an adverse effect on both."	3.67	Effect of phenytoin and/or beta-aminoproprionitrile on a surgically induced periosteal wound. ( Kuebel, MA; Taylor, JJ; Yeager, VL, 1985)
"Chronic treatment of female rats with buformin (k mg/day per rat) is shown to decrease the body weight, to increase the average life span by 9% and to reduce the incidence of spontaneous tumors."	3.66	[Effect of buformin and diphenylhydantoin on the life span, estrous function and spontaneous tumor incidence in rats]. ( Anisimov, VN, 1980)
"Analysis of plasma phenytoin in a group of patients treated for epilepsy showed that only 36% had values in the therapeutic range."	3.66	Prediction of phenytoin dosage in epilepsy using multiple linear regression. ( Gray, SP, 1982)
"A survey was carried out into the degree of gingival hyperplasia in 68 patients receiving phenytoin in a hospital for the mentally handicapped."	3.66	Risk factors in phenytoin-induced gingival hyperplasia. ( Addy, V; Campbell, N; D'Arcy, PF; Eyre, DG; McElnay, JC, 1983)
" Pretreatment with the nonembryotoxic dosage of 10 mg FCZ/kg potentiated PHT-induced teratogenesis, as indicated by a twofold (from 6."	2.69	Teratological interaction between the bis-triazole antifungal agent fluconazole and the anticonvulsant drug phenytoin. ( Bellati, U; Di Ilio, C; Giampietro, F; Iammarrone, E; Lamonaca, D; Tiboni, GM, 1999)
"Lamotrigine (LTG) is a new antiepileptic drug (AED), chemically unrelated to the drugs in current use."	2.68	Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication. ( Jürgens, U; May, TW; Rambeck, B, 1996)
"Peak phenytoin serum levels were detected six hours post-dosing at 2."	2.67	Some characteristics of serum phenytoin concentration, in black Zimbabwean volunteers. ( Mwaluko, GM; Nhachi, CF, 1992)
" Its use would enable practitioners to generate their patients' own parameters for use in individual dosage adjustments."	2.67	Pharmacokinetics of phenytoin in routine clinic patients in Malaysia. ( Chand, P; Ismail, R; Rahman, AF, 1994)
" Simulation results showed that the dosing interval should be reduced to achieve optimal dosing in neonates and infants, and the optimal dose required increases with weight."	1.51	Optimal Dosing Regimen of Phenytoin for Korean Epilepsy Patients: From Premature Babies to the Elderly. ( Chae, D; Guk, J; Kim, JH; Lee, SG; Park, K, 2019)
"Despite the widespread use of diphenylhydantoin (DPH), there is a lack of reliable information on the teratogenic effects, correlation with maternal and developmental toxicity, and dose-response relationship of DPH."	1.38	Dose-response effects of diphenylhydantoin on pregnant dams and embryo-fetal development in rats. ( Baek, HS; Kim, JC; Kim, SH; Lee, IC; Lim, JH; Moon, C; Park, SC; Shin, DH, 2012)
"To develop a population pharmacokinetic model to evaluate the effects of variety of covariates on clearance of carbamazepine (CBZ) and its main metabolite carbamazepine-10,11-epoxide (CBZE) in Chinese population."	1.32	Population pharmacokinetic modeling of steady state clearance of carbamazepine and its epoxide metabolite from sparse routine clinical data. ( Jiao, Z; Shi, XJ; Zhao, ZG; Zhong, MK, 2004)
"The aims of the present study were (1) to investigate and quantify the pharmacokinetics, including inter-occasion variability and covariate relationships, of busulphan in BMT patients and (2) to develop a user-friendly initial dosing and therapeutic drug monitoring (TDM) strategy for the treatment of those patients with busulphan."	1.31	Population pharmacokinetic analysis resulting in a tool for dose individualization of busulphan in bone marrow transplantation recipients. ( Bekassy, A; Hassan, M; Hassan, Z; Jonsson, EN; Karlsson, MO; Ljungman, P; Nilsson, C; Oberg, G; Ringden, O; Sandström, M, 2001)
"The influence of various covariates (including weight, race, smoking, gender, age, mild-to-moderate alcohol intake, and body surface area) on the population pharmacokinetic parameters of phenytoin in adult epileptic patients in South Africa was investigated."	1.30	Factors influencing the population pharmacokinetic parameters of phenytoin in adult epileptic patients in South Africa. ( Folb, PI; McFadyen, ML; Miller, R; Seymour, MA; Valodia, P, 1999)
" This finding indicates the need for further investigation into the effects of phenytoin on brain regions other than the cerebellum, as intellectual deterioration may be related to chronic use of this drug."	1.28	Lipopigment in rat hippocampal and Purkinje neurones after chronic phenytoin administration. ( Dowson, JH; James, NT; Wilton-Cox, H, 1992)
"Routine clinical pharmacokinetic data collected from patients receiving phenytoin have been analysed to propose a new and simple equation to aid the dosage adjustment of this drug."	1.28	One-point feedback control method for phenytoin dosage adjustment. ( Aoyama, T; Higuchi, S; Yukawa, E, 1991)
"We reviewed our data from 122 records of patients taking phenytoin for the treatment of various types of epilepsy and selected 15 (age range 10-43 years old) who were on phenytoin alone to calculate Michaelis-Menten pharmacokinetic parameters."	1.28	Michaelis-Menten pharmacokinetics of phenytoin in adult Malaysian patients. ( Ismail, R; Rahman, AF, 1990)
" Pharmacokinetic sampling in oral and i."	1.28	Developmental toxicity and pharmacokinetics of oral and intravenous phenytoin in the rat. ( Binkerd, PE; Hendrickx, AG; Rowland, JR, 1990)
" These findings should therefore be considered when defining dosage regimens or interpreting serum drug concentrations."	1.28	Analysis of the factors influencing anti-epileptic drug concentrations--valproic acid. ( Aoyama, T; Higuchi, S; Hirata, K; Ieiri, I; Yamada, H, 1990)
" A dose-response study was followed by a detailed teratological study using a single dose of 3 mg."	1.28	Teratogenic effects of phenytoin on chick embryos. ( Shah, GL; Singh, M, 1989)
"The Michaelis-Menten pharmacokinetic parameters Vmax and Km were calculated for 17 epileptic Saudi patients receiving phenytoin."	1.28	Phenytoin Michaelis-Menten pharmacokinetics in Saudi patients. ( el-Sayed, YM; Islam, SI, 1989)
"Phenytoin, 55 mg/kg, was administered intraperitoneally (ip) to pregnant CD-1 mice at 0900 hr on gestational days 12 and 13."	1.28	Enhancement of murine phenytoin teratogenicity by the gamma-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine and by the glutathione depletor diethyl maleate. ( Helston, LM; Wells, PG; Wong, M, 1989)
"1."	1.27	Phenytoin effects on tissues of Mongolian gerbils (Meriones unguiculatus). ( Bastidas-Ramírez, BE; Garzón, P; López-Ortega, G; Mora-Galindo, J; Navarro-Ruiz, A; Sandoval-Rojas, S, 1983)
"Terbutaline has also been reported to raise HDL cholesterol."	1.27	Nonpharmacologic and pharmacologic alteration of high-density lipoprotein cholesterol: therapeutic approaches to prevention of atherosclerosis. ( Glueck, CJ, 1985)
"Phenytoin was mixed with powdered basal diet at levels of 0 (control), 0."	1.27	Long-term in vivo carcinogenicity study of phenytoin (5,5-diphenylhydantoin) in F344 rats. ( Furukawa, F; Hasegawa, R; Hayashi, Y; Jang, JJ; Sato, H; Takahashi, M; Toyoda, K, 1987)
"Zonisamide (CI-912) is an experimental antiepileptic drug."	1.27	Comparative pharmacokinetics of zonisamide (CI-912) in epileptic patients on carbamazepine or phenytoin monotherapy. ( Buchanan, RA; Friel, PN; Levy, RH; McLean, JR; Ojemann, LM; Shastri, RA; Wilensky, AJ, 1986)
" After a minimum of 10 half-lives of maintenance dosing on a fixed regimen, the accumulation of propylene glycol differed significantly among individuals because of variability in apparent clearance."	1.27	Pharmacokinetics of propylene glycol in humans during multiple dosing regimens. ( Elmquist, WF; Sawchuk, RJ; Yu, DK, 1985)
"Phenytoin treatment resulted in higher liver ascorbic acid tissue levels than in controls."	1.27	Alterations in tissue trace element and ascorbic acid metabolism in phenytoin-fed rats and mice. ( Dubick, MA; Keen, CL, 1985)
"In these tests latency to convulsions and lethality associated with electroshock were more sensitive to THC."	1.26	Comparative activity of delta9-tetrahydrocannabinol, diphenylhydantoin, phenobarbital and chlordiazepoxide on electroshcok seizure threshold in mice. ( Barry, H; Sofia, RD, 1977)
" The long half-life in adults makes single daily dosing realistic in terms of blood levels and anticonvulsant effectiveness."	1.26	Phenytoin kinetics in children. ( Carter, DE; Curless, RG; Walson, PD, 1976)
" Dose-response curves revealed that plasma, adipose, kidney and liver had levels which were, respectively, 1."	1.26	Toxicity and tissue residues from diphenylhydantoin fed to chickens. ( Polin, D; Ringer, RK, 1976)
" Subtherapeutic levels appear to be due to inadequate dosage adjustment."	1.26	The necessity of drug level monitoring in anticonvulsant drug therapy. ( Bailey, DG; Davis, HL; Johnson, GE; Wilson, TW, 1976)
" However, the apparent elimination half-life (t 1/2) for MIS was reduced by 20-67%, and the area under the curve (AUC) was decreased by 23-49% in plasma, brain and tumour."	1.26	Effects of pretreatment with phenobarbitone and phenytoin on the pharmacokinetics and toxicity of phenytoin on the pharmacokinetics and toxicity of misonidazole in mice. ( Workman, P, 1979)
"Syncopal episodes were due to ventricular tachycardia and fibrillation, which were not responsive to conventional antiarrhythmic agents used in two patients."	1.26	Liquid protein diets and torsade de pointes. ( Gaarder, TD; Goldstein, M; Kanegae, T; Mills, H; Montgomerie, JZ; Singh, BN, 1978)
" When clinically indicated the daily dosage rate was adjusted by 50 mg steps until a serum concentration of 10--20 mg/l was produced."	1.26	Individual variation in daily dosage requirements for phenytoin sodium in patients with epilepsy. ( Barot, MH; Grant, RH; Maheendran, KK; Mawer, GE; Woodcock, BG, 1978)
" No significant differences were seen in the pharmacokinetic parameters observed for antipyrine, a drug which is less than 10% bound to plasms proteins."	1.25	Pharmacokinetics of drugs in patients with the nephrotic syndrome. ( Azarnoff, DL; Cohlmia, JB; Gugler, R; Huffman, DH; Shoeman, DW, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	111 (67.27)	18.7374
1990's	31 (18.79)	18.2507
2000's	13 (7.88)	29.6817
2010's	8 (4.85)	24.3611
2020's	2 (1.21)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Study Aimed at Determining the Relation Between the Administered Dose and Exposure to Immunosuppressive Medication in Children After Solid Organ Transplantation[NCT01767350]				60 participants (Actual)	Observational	2013-02-28	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Effects of intraperitoneal administration of the phenytoin on the skeletal system of rat fetus. Seizure, 2011, Volume: 20, Issue:3 Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Body Weight; Bone and Bones; Embryo, Mammalia	2011
Bulimia: the emergence of a syndrome. The Australian and New Zealand journal of psychiatry, 1984, Volume: 18, Issue:2 Topics: Adolescent; Adult; Anorexia Nervosa; Attitude; Behavior Therapy; Body Weight; Electroencephalography	1984
Toxic effects of anticonvulsants: general principles. Pediatrics, 1974, Volume: 53, Issue:4 Topics: Adrenocorticotropic Hormone; Adult; Anticonvulsants; Benzodiazepinones; Body Surface Area; Body Weig	1974
Individualization of anticonvulsant therapy. The Medical clinics of North America, 1974, Volume: 58, Issue:5 Topics: Adolescent; Adult; Animals; Anticonvulsants; Body Weight; Dose-Response Relationship, Drug; Drug Int	1974

Article	Year
The association of patient weight and dose of fosphenytoin, levetiracetam, and valproic acid with treatment success in status epilepticus. Epilepsia, 2020, Volume: 61, Issue:6 Topics: Adolescent; Adult; Anticonvulsants; Body Weight; Dose-Response Relationship, Drug; Female; Humans; L	2020
Population pharmacokinetics of carbamazepine in elderly patients. Therapeutic drug monitoring, 2012, Volume: 34, Issue:2 Topics: Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Body Weight; Carbamazepine; Dose-Response Rel	2012
Pharmacokinetics of phenytoin in routine clinic patients in Malaysia. Journal of clinical pharmacy and therapeutics, 1994, Volume: 19, Issue:4 Topics: Adolescent; Adult; Asian People; Body Weight; Child; Epilepsy; Female; Humans; Linear Models; Malays	1994
Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication. Therapeutic drug monitoring, 1996, Volume: 18, Issue:5 Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; D	1996
Teratological interaction between the bis-triazole antifungal agent fluconazole and the anticonvulsant drug phenytoin. Teratology, 1999, Volume: 59, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Antifungal Agents; Body Weight; Cleft Palate;	1999
Total percentage body weight changes during add-on therapy with tiagabine, carbamazepine and phenytoin. Epilepsy research, 2000, Volume: 41, Issue:1 Topics: Anticonvulsants; Body Weight; Carbamazepine; Double-Blind Method; Drug Therapy, Combination; Epileps	2000
Phenytoin treatment of the binge-eating syndrome. The American journal of psychiatry, 1977, Volume: 134, Issue:11 Topics: Adolescent; Adult; Body Weight; Brain; Clinical Trials as Topic; Compulsive Behavior; Double-Blind M	1977
Some characteristics of serum phenytoin concentration, in black Zimbabwean volunteers. East African medical journal, 1992, Volume: 69, Issue:12 Topics: Administration, Oral; Adult; Black People; Body Weight; Drug Monitoring; Female; Humans; Liver Funct	1992
Which drug for the adult epileptic patient: phenytoin or valproate? British medical journal (Clinical research ed.), 1985, Mar-16, Volume: 290, Issue:6471 Topics: Adolescent; Adult; Aged; Body Weight; Clinical Trials as Topic; Epilepsies, Partial; Epilepsy; Femal	1985
Bioavailability of diphenylhydantoin. Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:4 Topics: Administration, Oral; Adult; Analysis of Variance; Biological Availability; Blood Proteins; Body Wei	1974

Article	Year
Synthesis and evaluation of N-(phenylacetyl)trifluoromethanesulfonamides as anticonvulsant agents. Journal of medicinal chemistry, 1996, Mar-29, Volume: 39, Issue:7 Topics: Animals; Anticonvulsants; Body Weight; Cytochrome P-450 Enzyme System; Epilepsy; Mesylates; Mice; NA	1996
Evaluation of phenytoin loading doses in overweight patients using actual versus adjusted body weight. Epilepsy & behavior : E&B, 2022, Volume: 134 Topics: Body Mass Index; Body Weight; Humans; Overweight; Phenytoin; Retrospective Studies	2022
Optimal Dosing Regimen of Phenytoin for Korean Epilepsy Patients: From Premature Babies to the Elderly. Journal of pharmaceutical sciences, 2019, Volume: 108, Issue:8 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Body Weight; Child; Child, Preschool; D	2019
Characterization of unbound phenytoin concentrations in neurointensive care unit patients using a revised Winter-Tozer equation. The Annals of pharmacotherapy, 2013, Volume: 47, Issue:5 Topics: Adult; Age Factors; Aged; Algorithms; Anticonvulsants; Body Weight; Creatinine; Critical Illness; Hu	2013
Population Pharmacokinetics of Topiramate in Japanese Pediatric and Adult Patients With Epilepsy Using Routinely Monitored Data. Therapeutic drug monitoring, 2017, Volume: 39, Issue:2 Topics: Adolescent; Adult; Aged; Anticonvulsants; Asian People; Body Weight; Carbamazepine; Child; Child, Pr	2017
Dose adjustment of phenytoin for comedication in Japanese patients with epilepsy. Therapeutic drug monitoring, 2009, Volume: 31, Issue:1 Topics: Adult; Aged; Aging; Algorithms; Anticonvulsants; Body Surface Area; Body Water; Body Weight; Drug In	2009
Reduction of hippocampal CA 1 neurons in Wistar rats following the administration of phenytoin for seven days. African journal of medicine and medical sciences, 2007, Volume: 36, Issue:2 Topics: Animals; Anticonvulsants; Body Weight; Hippocampus; Injections, Intraperitoneal; Neurons; Phenytoin;	2007
Effect of prolonged phenytoin administration on rat brain gene expression assessed by DNA microarrays. Experimental biology and medicine (Maywood, N.J.), 2010, Volume: 235, Issue:3 Topics: Animals; Antimanic Agents; Bipolar Disorder; Body Weight; Brain; Disease Models, Animal; Frontal Lob	2010
Concentrations of stiripentol in children and adults with epilepsy: the influence of dose, age, and comedication. Therapeutic drug monitoring, 2012, Volume: 34, Issue:4 Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Child; Child, Preschool; Dioxolanes; Dose-Response	2012
Dose-response effects of diphenylhydantoin on pregnant dams and embryo-fetal development in rats. Birth defects research. Part B, Developmental and reproductive toxicology, 2012, Volume: 95, Issue:5 Topics: Animals; Body Weight; Bone and Bones; Cesarean Section; Dose-Response Relationship, Drug; Embryonic	2012
Neurotoxic damage of granule cells in the dentate gyrus and the cerebellum and cognitive deficit following neonatal administration of phenytoin in mice. Journal of neuropathology and experimental neurology, 2002, Volume: 61, Issue:11 Topics: Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Body Weight; Cerebellum; Cognition Disorders;	2002
Variability of total phenytoin serum concentrations within elderly nursing home residents. Neurology, 2003, Feb-25, Volume: 60, Issue:4 Topics: Age Distribution; Aged; Aged, 80 and over; Body Weight; Dosage Forms; Drug Administration Routes; Ep	2003
Developmental changes in the liver weight- and body weight-normalized clearance of theophylline, phenytoin and cyclosporine in children. International journal of clinical pharmacology and therapeutics, 2002, Volume: 40, Issue:11 Topics: Administration, Oral; Adolescent; Age Factors; Aryl Hydrocarbon Hydroxylases; Body Surface Area; Bod	2002
Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration. Central European journal of public health, 2004, Volume: 12 Suppl Topics: Abnormalities, Drug-Induced; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Body	2004
Population pharmacokinetic modeling of steady state clearance of carbamazepine and its epoxide metabolite from sparse routine clinical data. Journal of clinical pharmacy and therapeutics, 2004, Volume: 29, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Asian People; Body Weight; Carbamazepine;	2004
Maternal antioxidant supplementation does not reduce the incidence of phenytoin-induced cleft lip and related malformations in rats. Birth defects research. Part B, Developmental and reproductive toxicology, 2005, Volume: 74, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Antioxidants; Ascorbic Acid; Body Weight; Cle	2005
A comparison study of effects of Echinacea extract and levamisole on phenytoin-induced cleft palate in mice. Regulatory toxicology and pharmacology : RTP, 2006, Volume: 46, Issue:3 Topics: Animals; Biometry; Body Weight; Cleft Palate; Echinacea; Female; Fetus; Levamisole; Male; Maternal E	2006
Absence of characteristic reactions in the periodontium and other peripheral tissues of hamsters showing neurophysiologic response to chronic administration of 5,5-diphenylhydantoin (dilantin). Journal of oral therapeutics and pharmacology, 1967, Volume: 3, Issue:4 Topics: Adrenal Glands; Alveolar Process; Animals; Body Weight; Bone Resorption; Cricetinae; Female; Gingiva	1967
Phenytoin effects on tissues of Mongolian gerbils (Meriones unguiculatus). General pharmacology, 1983, Volume: 14, Issue:3 Topics: Animals; Body Weight; Brain Chemistry; DNA; Female; Gerbillinae; Liver; Macromolecular Substances; M	1983
Influence of vitamin D3 status, phenobarbital, and diphenylhydantoin treatment on the plasma 25-hydroxyvitamin D3 concentrations in the rat. Canadian journal of physiology and pharmacology, 1981, Volume: 59, Issue:10 Topics: Alanine Transaminase; Aniline Hydroxylase; Animals; Body Weight; Calcifediol; Cholecalciferol; Cytoc	1981
The bone inductive capacity of decalcified bone matrix modified by diphenylhydantoin. Acta orthopaedica Scandinavica, 1981, Volume: 52, Issue:5 Topics: Animals; Body Weight; Bone Development; Bone Matrix; Calcium; Cartilage; Cholecalciferol; Hypertroph	1981
Low protein-high carbohydrate diet induces alterations in the serum thyronine-binding proteins in the rat. Endocrinology, 1982, Volume: 110, Issue:5 Topics: Animals; Body Weight; Dietary Carbohydrates; Male; Phenytoin; Protein-Energy Malnutrition; Rats; Rat	1982
Risk factors in phenytoin-induced gingival hyperplasia. Journal of periodontology, 1983, Volume: 54, Issue:6 Topics: Adolescent; Adult; Age Factors; Aged; Body Weight; Child; Female; Gingival Hyperplasia; Humans; Male	1983
Behavioral outcome after prenatal exposure to phenytoin in rats. Teratology, 1983, Volume: 27, Issue:2 Topics: Aging; Animals; Behavior, Animal; Body Weight; Female; Learning; Motor Activity; Phenytoin; Pregnanc	1983
Influence of liver enzyme induction caused by diphenylhydantoin and diazepam on bone mass of rats. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1980, Volume: 4 Topics: Animals; Body Weight; Bone and Bones; Bone Development; Calcium; Diazepam; Enzyme Induction; Glucari	1980
Anticonvulsant therapy and vitamin D metabolism: evidence for different mechanisms for phenytoin and phenobarbital. Pediatric pharmacology (New York, N.Y.), 1980, Volume: 1, Issue:2 Topics: 25-Hydroxyvitamin D 2; Animals; Body Weight; Diet; Ergocalciferols; Male; Parathyroid Hormone; Pheno	1980
Prediction of phenytoin dosage in epilepsy using multiple linear regression. Annals of clinical biochemistry, 1982, Volume: 19, Issue:3 Topics: Body Weight; Dose-Response Relationship, Drug; Epilepsy; Humans; Phenytoin	1982
Phenytoin effects on liver cellularity and function of adult rats. General pharmacology, 1982, Volume: 13, Issue:3 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; DNA; Female; Liver; Male; P	1982
Hemodialysis reduces the unbound phenytoin in plasma. The Journal of pediatrics, 1982, Volume: 101, Issue:3 Topics: Adolescent; Adult; Blood Proteins; Body Weight; Child; Humans; Phenytoin; Protein Binding; Renal Dia	1982
Phenytoin--allopurinol interaction: Michaelis--Menten kinetic parameters of phenytoin with and without allopurinol in a child with Lesch--Nyhan syndrome. Therapeutic drug monitoring, 1982, Volume: 4, Issue:4 Topics: Adolescent; Allopurinol; Body Weight; Child; Child, Preschool; Drug Interactions; Humans; Kinetics;	1982
[Effect of buformin and diphenylhydantoin on the life span, estrous function and spontaneous tumor incidence in rats]. Voprosy onkologii, 1980, Volume: 26, Issue:6 Topics: Animals; Biguanides; Body Weight; Buformin; Estrus; Female; Longevity; Neoplasms, Experimental; Phen	1980
Phenytoin, methysergide, and penicillamine in hereditary muscular dystrophy of the chicken. Experimental neurology, 1981, Volume: 72, Issue:1 Topics: Acetylcholinesterase; Animals; Body Weight; Chickens; Creatine Kinase; Drug Evaluation, Preclinical;	1981
Comparative teratogenicity of cortisone and phenytoin in mice. Journal of pharmaceutical sciences, 1981, Volume: 70, Issue:6 Topics: Animals; Body Weight; Cleft Palate; Cortisone; Dose-Response Relationship, Drug; Female; Fetal Resor	1981
Pharmacokinetics of phenytoin in children. British journal of clinical pharmacology, 1981, Volume: 12, Issue:5 Topics: Body Weight; Child, Preschool; Female; Humans; Infant; Kinetics; Liver; Male; Organ Size; Phenytoin	1981
Antagonism of frusemide diuresis by diphenylhydantoin sodium. The Indian journal of medical research, 1981, Volume: 74 Topics: Animals; Body Weight; Diuresis; Furosemide; Male; Phenytoin; Rats; Rats, Inbred Strains	1981
[Problems of therapeutic service in carbamazepine therapy]. Zeitschrift fur arztliche Fortbildung, 1980, Aug-01, Volume: 74, Issue:15 Topics: Adult; Biotransformation; Body Weight; Carbamazepine; Child; Drug Interactions; Humans; Phenytoin	1980
n-3 fatty acids inhibit defects and fatty acid changes caused by phenytoin in early gestation in mice. Lipids, 1994, Volume: 29, Issue:11 Topics: Abnormalities, Drug-Induced; Animal Feed; Animals; Body Weight; Fatty Acids, Omega-3; Fatty Acids, U	1994
Therapeutic drug monitoring of phenytoin in patients with the acquired immunodeficiency syndrome. Therapeutic drug monitoring, 1994, Volume: 16, Issue:6 Topics: Acquired Immunodeficiency Syndrome; Adult; Age Factors; Body Weight; Drug Interactions; Drug Monitor	1994
Long-term treatment with 5,5-diphenylhydantoin reduces lymphadenopathy and anti-ssDNA autoantibodies in C57BL/6-lpr/lpr mice. International journal of immunopharmacology, 1994, Volume: 16, Issue:3 Topics: Animals; Antibodies, Antinuclear; Autoimmune Diseases; Biopterins; Body Weight; Drug Administration	1994
Tumor promotion by an anticonvulsant agent, phenytoin, in mouse liver: correlation with CYP2B induction. Carcinogenesis, 1993, Volume: 14, Issue:11 Topics: Adenoma; Animals; Body Weight; Carcinogens; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System;	1993
Effects of phenytoin on the in vivo kinetics of thiamine and its phosphoesters in rat nervous tissues. Brain research, 1993, Nov-19, Volume: 628, Issue:1-2 Topics: Animals; Behavior, Animal; Body Weight; Brain; Male; Phenytoin; Phosphorylation; Rats; Rats, Wistar;	1993
Comparative carcinogenicity of 5,5-diphenylhydantoin with or without perinatal exposure in rats and mice. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1993, Volume: 21, Issue:2 Topics: Adenoma, Liver Cell; Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Female; Fetal Dea	1993
Anti-convulsant drugs, smoking, and body weights in psychiatric in-patients. New York state journal of medicine, 1993, Volume: 93, Issue:1 Topics: Adult; Aged; Anticonvulsants; Body Weight; Cross-Sectional Studies; Female; Humans; Male; Middle Age	1993
Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, May-15, Volume: 16, Issue:10 Topics: Animals; Atrophy; Body Weight; Dendrites; Hippocampus; Hydrocortisone; Male; Phenytoin; Pyramidal Ce	1996
Phenytoin embryopathy: effect of epoxide hydrolase inhibitor on phenytoin exposure in utero in C57BL/6J mice. Biochemical and molecular medicine, 1995, Volume: 56, Issue:2 Topics: Animals; Anticonvulsants; Body Weight; Drug Interactions; Enzyme Inhibitors; Epoxide Hydrolases; Fem	1995
Factors influencing the population pharmacokinetic parameters of phenytoin in adult epileptic patients in South Africa. Therapeutic drug monitoring, 1999, Volume: 21, Issue:1 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alcohol Drinking; Amino Acid Sequence; Anti	1999
Population pharmacokinetics of tirilazad: effects of weight, gender, concomitant phenytoin, and subarachnoid hemorrhage. Pharmaceutical research, 1999, Volume: 16, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Antioxidants; Body Weight; Drug Interac	1999
Hepatic drug metabolizing enzyme induction and serum triacylglycerol elevation in rats treated with chlordiazepoxide, griseofulvin, rifampicin and phenytoin. Clinica chimica acta; international journal of clinical chemistry, 1999, Volume: 289, Issue:1-2 Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Body Weight; Chlordiazepoxide; Cytosol; Enz	1999
Phenytoin, midazolam, and naloxone protect against fentanyl-induced brain damage in rats. Anesthesia and analgesia, 2000, Volume: 91, Issue:6 Topics: Analgesics, Opioid; Animals; Anticonvulsants; Blood Gas Analysis; Body Weight; Brain Diseases; Elect	2000
Phenytoin-induced bone loss and its prevention with alfacalcidol or calcitriol in growing rats. Calcified tissue international, 2001, Volume: 69, Issue:2 Topics: Animals; Body Weight; Bone Density; Bone Diseases, Metabolic; Calcitriol; Hydroxycholecalciferols; M	2001
Population pharmacokinetic analysis resulting in a tool for dose individualization of busulphan in bone marrow transplantation recipients. Bone marrow transplantation, 2001, Volume: 28, Issue:7 Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Antineoplastic Agents, Alkylating; Area Un	2001
Letter: Serum-phenytoin and body-weight. Lancet (London, England), 1976, Apr-10, Volume: 1, Issue:7963 Topics: Adult; Body Weight; Dose-Response Relationship, Drug; Epilepsy; Humans; Male; Phenytoin	1976
Effects of phenobarbital and diphenylhydantoin on acute vitamin D3 toxicity in the rat. Toxicology and applied pharmacology, 1978, Volume: 43, Issue:1 Topics: Animals; Body Weight; Cholecalciferol; Lethal Dose 50; Liver; Male; Phenobarbital; Phenytoin; Rats	1978
Effect of diphenylhydantoin on the apposition of dentin. An experimental study in the rat. Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran toimituksia, 1977, Volume: 73, Issue:4-6 Suppl Topics: Alkaline Phosphatase; Animals; Body Weight; Calcium; Cholecalciferol; Connective Tissue; Dentinogene	1977
Bone changes induced by diphenylhydantoin in chicks on a controlled vitamin D intake. The Journal of bone and joint surgery. American volume, 1978, Volume: 60, Issue:7 Topics: Animals; Body Weight; Bone and Bones; Cholecalciferol; Male; Microradiography; Nutritional Requireme	1978
The effect of selected drugs on first-stage radioemesis in beagle dogs. Radiation research, 1979, Volume: 78, Issue:2 Topics: Amifostine; Amphetamine; Animals; Antiemetics; Body Weight; Chlorpromazine; Dimenhydrinate; Diphenhy	1979
The effects of diphenylhydantoin and vitamin D deficiency on developing teeth in the rat. Archives of oral biology, 1978, Volume: 23, Issue:3 Topics: Animals; Body Weight; Odontometry; Phenytoin; Rats; Time Factors; Tooth; Vitamin D Deficiency	1978
[Calcium metabolism and anticonvulsants drugs. Experimental study]. AMB : revista da Associacao Medica Brasileira, 1979, Volume: 25, Issue:1 Topics: Alkaline Phosphatase; Animals; Body Weight; Calcium; Hydroxyproline; Liver; Male; Phenobarbital; Phe	1979
Electroencephalographic correlates of compulsive eating. Clinical EEG (electroencephalography), 1979, Volume: 10, Issue:4 Topics: Adult; Body Weight; Brain; Compulsive Behavior; Eating; Electroencephalography; Feeding Behavior; Fe	1979
Effects of pretreatment with phenobarbitone and phenytoin on the pharmacokinetics and toxicity of phenytoin on the pharmacokinetics and toxicity of misonidazole in mice. British journal of cancer, 1979, Volume: 40, Issue:3 Topics: Animals; Body Temperature; Body Weight; Brain; Drug Interactions; Half-Life; Lethal Dose 50; Liver;	1979
Influence of cobalt (dietary), cobalamins, and inorganic cobalt salts on phenytoin- and cortisone-induced teratogenesis in mice. Journal of pharmaceutical sciences, 1978, Volume: 67, Issue:3 Topics: Animals; Body Weight; Cobalt; Cortisone; Female; Fetus; Male; Maternal-Fetal Exchange; Mice; Organ S	1978
Liquid protein diets and torsade de pointes. JAMA, 1978, Jul-14, Volume: 240, Issue:2 Topics: Adult; Arrhythmias, Cardiac; Body Weight; Death, Sudden; Diet, Reducing; Dietary Proteins; Electroca	1978
Individual variation in daily dosage requirements for phenytoin sodium in patients with epilepsy. British journal of clinical pharmacology, 1978, Volume: 6, Issue:3 Topics: Adult; Age Factors; Body Weight; Drug Administration Schedule; Epilepsy; Female; Glucaric Acid; Huma	1978
Sodium valproate in the treatment of resistant epilepsy. Acta neurologica Scandinavica, 1976, Volume: 54, Issue:3 Topics: Adolescent; Adult; Alopecia; Anticonvulsants; Body Weight; Diarrhea; Drug Interactions; Epilepsies,	1976
Comparative activity of delta9-tetrahydrocannabinol, diphenylhydantoin, phenobarbital and chlordiazepoxide on electroshcok seizure threshold in mice. Archives internationales de pharmacodynamie et de therapie, 1977, Volume: 228, Issue:1 Topics: Animals; Body Weight; Chlordiazepoxide; Dronabinol; Electroshock; Glucose; Male; Mice; Phenobarbital	1977
Phenytoin kinetics in children. Neurology, 1976, Volume: 26, Issue:8 Topics: Age Factors; Body Weight; Child; Child, Preschool; Female; Half-Life; Humans; Infant; Kinetics; Male	1976
Epileptic seizures in women related to plasma estrogen and progesterone during the menstrual cycle. Acta neurologica Scandinavica, 1976, Volume: 54, Issue:4 Topics: Adolescent; Adult; Body Weight; Estrogens; Female; Humans; Menstruation; Middle Aged; Ovulation; Phe	1976
Toxicity and tissue residues from diphenylhydantoin fed to chickens. Poultry science, 1976, Volume: 55, Issue:5 Topics: Adipose Tissue; Animal Feed; Animals; Body Weight; Chickens; Female; Hemorrhage; Liver; Male; Muscle	1976
The necessity of drug level monitoring in anticonvulsant drug therapy. Canadian journal of physiology and pharmacology, 1976, Volume: 54, Issue:6 Topics: Body Weight; Dose-Response Relationship, Drug; Epilepsy; Humans; Patient Compliance; Phenobarbital;	1976
Iatrogenic diphenylhydantoin (dilantin) intoxication. Texas medicine, 1975, Volume: 71, Issue:2 Topics: Age Factors; Body Weight; Child; Child, Preschool; Epilepsy, Temporal Lobe; Female; Humans; Iatrogen	1975
Pharmacokinetics of drugs in patients with the nephrotic syndrome. The Journal of clinical investigation, 1975, Volume: 55, Issue:6 Topics: Adult; Antipyrine; Blood Proteins; Body Weight; Clofibrate; Dose-Response Relationship, Drug; Female	1975
Teratogenicity of oral diazepam and diphenylhydantoin in mice. Toxicology and applied pharmacology, 1975, Volume: 32, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Diazepam; Female; Fetal Death; Fetu	1975
Effects and complications of high efficiency dialysis. Nephron, 1975, Volume: 15, Issue:2 Topics: Barbiturates; Blood Urea Nitrogen; Body Weight; Calcium; Creatinine; Edema; Headache; Humans; Hypote	1975
[Anti epileptic therapy with diphenylhydantoin with serum controls in childhood. Clinical experiences]. Bibliotheca psychiatrica, 1975, Issue:151 Topics: Adolescent; Body Weight; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Phenytoin	1975
Variability of creatinine excretion of normal, phenylketonuric and galactosemic children, and children treated with anticonvulsant drugs. The American journal of clinical nutrition, 1975, Volume: 28, Issue:4 Topics: Body Height; Body Weight; Child; Child, Preschool; Circadian Rhythm; Creatinine; Female; Galactosemi	1975
Effects of chronic administration of sodium diphenylhydantoin ('Dilantin') on bones and teeth of the rat and hamster: a preliminary study. Calcified tissue research, 1975, Jun-02, Volume: 17, Issue:3 Topics: Animals; Body Weight; Bone and Bones; Bone Development; Cartilage; Cricetinae; Mesocricetus; Organ S	1975
Bone mineral in mentally retarded patients receiving long-term anticonvulsive therapy. Growth, 1975, Volume: 39, Issue:3 Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Body Weight; Bone and Bones; Child; Female; Humans;	1975
Diphenylhydantoin effects on hexobarbital and aniline biotransformation in male rats: differences between in vitro and in vivo observations. Toxicology and applied pharmacology, 1975, Volume: 34, Issue:2 Topics: Aniline Compounds; Animals; Biotransformation; Body Weight; Hexobarbital; In Vitro Techniques; Liver	1975
[Correction of endocrine-metabolic disorders in oncologic patients. The effect of biguanides (phenformin and adebita), miskleron and diphenin]. Voprosy onkologii, 1975, Volume: 21, Issue:11 Topics: Adrenal Cortex Hormones; Aged; Biguanides; Blood Glucose; Body Weight; Breast Neoplasms; Buformin; C	1975
Effect of age, height, weight and sex on serum phenytoin concentration in epileptic patients. British journal of clinical pharmacology, 1975, Volume: 2, Issue:3 Topics: Adult; Age Factors; Aged; Body Height; Body Weight; Epilepsy; Female; Humans; Male; Middle Aged; Phe	1975
[Determination of serum diphenylhydantoin during antiepileptic therapy]. Der Nervenarzt, 1976, Volume: 47, Issue:4 Topics: Adolescent; Adult; Aged; Body Weight; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Ma	1976
Phenytoin prevents stress- and corticosterone-induced atrophy of CA3 pyramidal neurons. Hippocampus, 1992, Volume: 2, Issue:4 Topics: Adrenal Glands; Animals; Atrophy; Body Weight; Corticosterone; Dendrites; Hippocampus; Male; Neurons	1992
Diphenylhydantoin inhibits calcification of bovine pericardial implants and myocardium: a preliminary study. The Journal of surgical research, 1992, Volume: 53, Issue:4 Topics: Animals; Bioprosthesis; Body Weight; Calcification, Physiologic; Calcinosis; Cardiomyopathies; Cattl	1992
Clinical and experimental studies linking oxidative metabolism to phenytoin-induced teratogenesis. Neurology, 1992, Volume: 42, Issue:4 Suppl 5 Topics: Abnormalities, Drug-Induced; Amnion; Animals; Anticonvulsants; Body Weight; Dioxolanes; Epoxide Hydr	1992
Lipopigment in rat hippocampal and Purkinje neurones after chronic phenytoin administration. Journal of the neurological sciences, 1992, Volume: 107, Issue:1 Topics: Aging; Animals; Body Weight; Hippocampus; Lipids; Male; Phenytoin; Pigments, Biological; Purkinje Ce	1992
One-point feedback control method for phenytoin dosage adjustment. The Journal of pharmacy and pharmacology, 1991, Volume: 43, Issue:7 Topics: Adolescent; Adult; Aged; Bayes Theorem; Body Weight; Child; Child, Preschool; Female; Humans; Infant	1991
Urinary biopterin levels in mice during graft-versus-host reactions and during exposure to 5,5-diphenylhydantoin. International journal of immunopharmacology, 1991, Volume: 13, Issue:5 Topics: Animals; Biopterins; Body Weight; Circadian Rhythm; Creatine; Female; Graft vs Host Disease; Lymphoc	1991
Diazepam and intubation in emergency treatment of seizures in children. Annals of emergency medicine, 1991, Volume: 20, Issue:9 Topics: Adolescent; Body Weight; Case-Control Studies; Child; Child, Preschool; Diazepam; Drug Therapy, Comb	1991
Comparison of the effects of propylthiouracil, amiodarone, diphenylhydantoin, phenobarbital, and 3-methylcholanthrene on hepatic and renal T4 metabolism and thyroid gland function in rats. Toxicology and applied pharmacology, 1991, Volume: 111, Issue:2 Topics: Amiodarone; Animals; Body Weight; Cytochrome P-450 Enzyme System; Cytochromes b5; Glucuronosyltransf	1991
Permanent alterations in the hypothalamic-pituitary-thyroid axis in the rat following phenytoin exposure in utero. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1990, Volume: 22, Issue:10 Topics: Animals; Body Weight; Female; Hypothalamo-Hypophyseal System; Maternal-Fetal Exchange; Phenytoin; Pr	1990
Michaelis-Menten pharmacokinetics of phenytoin in adult Malaysian patients. Journal of clinical pharmacy and therapeutics, 1990, Volume: 15, Issue:6 Topics: Adolescent; Adult; Aging; Body Weight; Child; Female; Humans; Malaysia; Male; Phenytoin; Regression	1990
Developmental toxicity and pharmacokinetics of oral and intravenous phenytoin in the rat. Reproductive toxicology (Elmsford, N.Y.), 1990, Volume: 4, Issue:3 Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Body Weight; Female; Fetal Resorption; H	1990
Population pharmacokinetics of phenytoin in Singapore Chinese. European journal of clinical pharmacology, 1990, Volume: 39, Issue:2 Topics: Adolescent; Adult; Aged; Aging; Bayes Theorem; Body Weight; Child; Child, Preschool; China; Female;	1990
Analysis of the factors influencing anti-epileptic drug concentrations--carbamazepine. Journal of clinical pharmacy and therapeutics, 1990, Volume: 15, Issue:5 Topics: Aging; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Female; Huma	1990
Analysis of the factors influencing anti-epileptic drug concentrations--valproic acid. Journal of clinical pharmacy and therapeutics, 1990, Volume: 15, Issue:5 Topics: Adolescent; Adult; Aging; Aspartate Aminotransferases; Body Weight; Carbamazepine; Dose-Response Rel	1990
The fetal hydantoin syndrome: answers from a mouse model. Reproductive toxicology (Elmsford, N.Y.), 1989, Volume: 3, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Disease Models, Animal; Embryo Implantation; Fema	1989
Teratogenic effects of phenytoin on chick embryos. Teratology, 1989, Volume: 40, Issue:5 Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Chick Embryo; Dose-Response Relationship, Drug; E	1989
Phenytoin Michaelis-Menten pharmacokinetics in Saudi patients. International journal of clinical pharmacology, therapy, and toxicology, 1989, Volume: 27, Issue:4 Topics: Adolescent; Adult; Aging; Body Weight; Child; Child, Preschool; Female; Fluorescence Polarization; H	1989
Enhancement of murine phenytoin teratogenicity by the gamma-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine and by the glutathione depletor diethyl maleate. Teratology, 1989, Volume: 40, Issue:2 Topics: Administration, Oral; Analysis of Variance; Animals; Body Weight; Buthionine Sulfoximine; Cleft Pala	1989
Prenatal exposure to phenytoin and its effect on postnatal growth and craniofacial proportion in the rat. Journal of craniofacial genetics and developmental biology, 1989, Volume: 9, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone Development; Eye Abnormalities; Face; Female	1989
Nonpharmacologic and pharmacologic alteration of high-density lipoprotein cholesterol: therapeutic approaches to prevention of atherosclerosis. American heart journal, 1985, Volume: 110, Issue:5 Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Arteriosclerosis; Body Weight; Cholesterol, H	1985
Relationship between ossification and body weight of the CD-1 mouse fetus exposed in utero to anticonvulsant drugs. Teratogenesis, carcinogenesis, and mutagenesis, 1986, Volume: 6, Issue:6 Topics: Animals; Anticonvulsants; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; Female; Fetu	1986
Fasting induces the generation of serum thyronine-binding globulin in Zucker rats. Endocrinology, 1985, Volume: 116, Issue:4 Topics: Animals; Body Weight; Fasting; Iodine Radioisotopes; Male; Obesity; Phenytoin; Rats; Rats, Mutant St	1985
Effects of dietary xenobiotics on the metabolism of copper, alpha-tocopherol and cholesterol in rats. Journal of nutritional science and vitaminology, 1987, Volume: 33, Issue:4 Topics: Animals; Body Weight; Butylated Hydroxyanisole; Caffeine; Ceruloplasmin; Chlorobutanol; Cholesterol;	1987
Lack of carcinogenicity of phenytoin in (C57BL/6 x C3H)F1 mice. Journal of toxicology and environmental health, 1988, Volume: 24, Issue:1 Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Female; Liver Neoplasms; Male; Mice; Phenyt	1988
Long-term in vivo carcinogenicity study of phenytoin (5,5-diphenylhydantoin) in F344 rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1987, Volume: 25, Issue:9 Topics: Animals; Body Weight; Eating; Female; Kidney; Liver; Male; Neoplasms, Experimental; Organ Size; Phen	1987
Developmental profile of serum androgens and estrous cyclicity of male and female rats exposed, perinatally, to maternally administered phenytoin. Toxicology letters, 1987, Volume: 39, Issue:2-3 Topics: Androgens; Animals; Body Weight; Dose-Response Relationship, Drug; Estrus; Female; Fetus; Male; Phen	1987
Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death. Research communications in chemical pathology and pharmacology, 1986, Volume: 51, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Body Weight; Bretylium Tosylate; Death, Sudden; Disease Models, Ani	1986
Persistent defects in the hepatic monooxygenase system of adult rats exposed, perinatally, to maternally administered phenytoin. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:1 Topics: Aminopyrine N-Demethylase; Animals; Body Weight; Female; Kinetics; Liver; Male; Microsomes, Liver; M	1986
Comparative pharmacokinetics of zonisamide (CI-912) in epileptic patients on carbamazepine or phenytoin monotherapy. Therapeutic drug monitoring, 1986, Volume: 8, Issue:3 Topics: Adolescent; Adult; Anticonvulsants; Body Weight; Carbamazepine; Drug Therapy, Combination; Epilepsy;	1986
Developmental effects of anticonvulsants. Neurotoxicology, 1986,Summer, Volume: 7, Issue:2 Topics: Animals; Anticonvulsants; Body Weight; Epilepsy; Female; Fetal Diseases; Humans; Motor Activity; Phe	1986
Effect of phenytoin and/or beta-aminoproprionitrile on a surgically induced periosteal wound. Journal of experimental pathology, 1985,Summer, Volume: 2, Issue:2 Topics: Administration, Oral; Aminopropionitrile; Animals; Body Weight; Cartilage; Fractures, Bone; Male; Pe	1985
Serum concentrations of valproic acid: influence of dose and comedication. Therapeutic drug monitoring, 1985, Volume: 7, Issue:4 Topics: Adolescent; Adult; Body Weight; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epileps	1985
Steady-state serum levels of anticonvulsant drugs in Chinese epileptic patients living in Taiwan. Therapeutic drug monitoring, 1985, Volume: 7, Issue:1 Topics: Adolescent; Adult; Age Factors; Asian People; Body Weight; Child; Epilepsy; Female; Humans; Male; Mi	1985
Pharmacokinetics of propylene glycol in humans during multiple dosing regimens. Journal of pharmaceutical sciences, 1985, Volume: 74, Issue:8 Topics: Adolescent; Adult; Aged; Body Weight; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Phenyt	1985
Alterations in tissue trace element and ascorbic acid metabolism in phenytoin-fed rats and mice. The Journal of nutrition, 1985, Volume: 115, Issue:11 Topics: Administration, Oral; Animals; Ascorbic Acid; Body Weight; Kidney; Liver; Male; Mice; Mixed Function	1985
Perinatal induction of hepatic aminopyrine N-demethylase by maternal exposure to phenytoin. Pediatric pharmacology (New York, N.Y.), 1985, Volume: 5, Issue:3 Topics: Aminopyrine N-Demethylase; Animals; Animals, Newborn; Body Weight; Enzyme Induction; Female; Kinetic	1985
[Diphenylhydantoin in children. Clinico-pharmacological studies]. Deutsche medizinische Wochenschrift (1946), 1973, Jul-20, Volume: 98, Issue:29 Topics: Adolescent; Alkaline Phosphatase; Ataxia; Body Weight; Calcium; Child; Child, Preschool; Diplopia; D	1973
[Influence of ascorbic acid and nicotinamide onthe body weight of rats treated with diphenylhydantoin]. Acta vitaminologica et enzymologica, 1969, Volume: 23, Issue:6 Topics: Animals; Ascorbic Acid; Body Weight; Niacinamide; Phenytoin; Rats	1969
The effect of ageing upon collagen metabolism. Symposia of the Society for Experimental Biology, 1967, Volume: 21 Topics: Aging; Animals; Body Weight; Burns; Citrates; Collagen; Cycloheximide; Desoxycorticosterone; Glycine	1967
Biochemical changes in rat liver in response to treatment with drugs and other agents. I. Effects of anticonvulsant, anti-inflammatory, hypocholesterolaemic and adrenergic beta-blocking agents. Biochemical pharmacology, 1969, Volume: 18, Issue:2 Topics: Acetanilides; Aminopyrine; Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Anticonvulsa	1969
Diphenylhydantoin: effects on calcium metabolism in the chick. Science (New York, N.Y.), 1974, Feb-15, Volume: 183, Issue:4125 Topics: Animals; Body Weight; Bone and Bones; Calcium; Calcium Radioisotopes; Chickens; Cholecalciferol; Dos	1974
Retarded growth of rats by anticonvulsant drugs. Epilepsia, 1974, Volume: 15, Issue:1 Topics: Animals; Body Weight; Cholecalciferol; Dwarfism; Female; Growth; Maternal-Fetal Exchange; Pentobarbi	1974
[Anticonvulsants and vitamin D metabolism (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1974, Sep-13, Volume: 116, Issue:37 Topics: Animals; Anticonvulsants; Avitaminosis; Body Weight; Calcium; Calcium Radioisotopes; Cholecalciferol	1974
Oxidative metabolism of skeletal muscle in steroid atrophy. Archives of neurology, 1974, Volume: 31, Issue:6 Topics: Animals; Body Weight; Carbon Radioisotopes; Dexamethasone; Glucose; Hydrocortisone; Hydroxybutyrates	1974
Plasma diphenylhydantoin levels in Australian adults. Australian and New Zealand journal of medicine, 1974, Volume: 4, Issue:5 Topics: Adolescent; Adult; Analysis of Variance; Australia; Body Weight; Chromatography, Gas; Dose-Response	1974
Long-term complete intravenous nutrition in man. Nutrition and metabolism, 1972, Volume: 14 Topics: Adipose Tissue; Adult; Amino Acids; Anemia, Macrocytic; Body Weight; Carbohydrates; Cholesterol; Ele	1972
Prevention by catatoxic steroids of lithocholic acid-induced biliary concrements in the rat. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1972, Volume: 141, Issue:2 Topics: Animals; Bile Acids and Salts; Body Weight; Common Bile Duct; Female; Gallstones; Jaundice; Lithocho	1972
Statistical approach to evaluating effect of physical and chemical factors on fecal excretion of chlorophenothane. Journal of pharmaceutical sciences, 1973, Volume: 62, Issue:9 Topics: Animals; Body Weight; Carbon Isotopes; Cold Temperature; DDT; Fasting; Feces; Male; Norepinephrine;	1973
Interactions of aspirin, indomethacin and other drugs in adjuvant-induced arthritis in the rat. The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:2 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Body Weight; Chlorpromazine; C	1973
Does diphenylhydantoin accelerate healing of fractures in mice? Acta orthopaedica Scandinavica, 1973, Volume: 44, Issue:6 Topics: Animals; Biomechanical Phenomena; Body Weight; Bony Callus; Collagen; Hindlimb; Hydroxyproline; Male	1973
Effects of inositol, diphenylhydantoin and phenobarbital on HEOD storage in rat adipose tissue. Bulletin of environmental contamination and toxicology, 1973, Volume: 9, Issue:6 Topics: Adipose Tissue; Aminopyrine N-Demethylase; Animals; Body Weight; Dieldrin; Inositol; Male; Microsome	1973
Diphenylhydantoin dosage. Proceedings of the Australian Association of Neurologists, 1973, Volume: 10, Issue:0 Topics: Adolescent; Adult; Age Factors; Body Weight; Child; Chromatography, Gas; Drug Interactions; Epilepsy	1973
[Concentration and persistence in the central nervous system. Experimental study on diphenylhydantoin]. Acta neurologica latinoamericana, 1973, Volume: 19, Issue:1-4 Topics: Animals; Body Weight; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Injections, Intramus	1973
Behavioral and physiological studies of a convulsing mutant chicken (Gallus domesticus). The Journal of experimental zoology, 1974, Volume: 187, Issue:1 Topics: Acoustic Stimulation; Age Factors; Animals; Behavior, Animal; Body Temperature; Body Weight; Chicken	1974
Treatment of compulsive eating disturbances with anticonvulsant medication. The American journal of psychiatry, 1974, Volume: 131, Issue:4 Topics: Adolescent; Adult; Amphetamine; Anorexia Nervosa; Body Image; Body Weight; Compulsive Behavior; Depr	1974
Effect of diphenylhydantoin on glucose tolerance in patients with hypoglycemia. Diabetes, 1974, Volume: 23, Issue:8 Topics: Administration, Oral; Adult; Blood Glucose; Body Height; Body Weight; Chromatography, Gas; Female; G	1974
The effect of diphenylhydantoin in vitro on the metabolism of testosterone by rat liver subcellular fractions. Acta endocrinologica, 1968, Volume: 57, Issue:4 Topics: Androsterone; Animals; Body Weight; Carbon Isotopes; Chromatography, Paper; Female; Histological Tec	1968
Diphenylhydantoin teratogenicity in rats. Toxicology and applied pharmacology, 1972, Volume: 22, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Cleft Palate; Female; Fetal Death	1972
Diphenylhydantoin: efficacy, toxicity, and dose-serum level relationships in children. The Journal of pediatrics, 1972, Volume: 81, Issue:5 Topics: Adolescent; Adult; Age Factors; Attitude to Health; Body Weight; Child; Child, Preschool; Dose-Respo	1972
Variations of serum diphenylhydantoin concentrations in epileptic out-patients. European neurology, 1971, Volume: 5, Issue:5 Topics: Adolescent; Adult; Aged; Blood Proteins; Body Weight; Drug Synergism; Epilepsy; Female; Humans; Male	1971
Metabolite(s) of diphenylhydantoin in human plasma inhibit(s) the pentose phosphate pathway of leukocytes. Pharmacology, 1971, Volume: 6, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Aged; Blood Glucose; Body Weight; Child, Preschool; Epileps	1971
Incidence of gingival hyperplasia associated with Dilantin therapy in a hospital population. Journal of the American Dental Association (1939), 1965, Volume: 71, Issue:6 Topics: Adolescent; Adult; Aged; Aging; Black or African American; Body Weight; Child; Child, Preschool; Fem	1965
Relation of dosage and time of administration of diphenylhydantoin to its teratogenic effect in mice. Teratology, 1969, Volume: 2, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Lip; Cleft Palate; Embryonic and Fetal Deve	1969
[Influence of food deprivation on efficacy and toxicity of drugs in mice]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1969, Mar-20, Volume: 65, Issue:2 Topics: Acetates; Aminopyrine; Analgesics; Animals; Anticonvulsants; Blood Glucose; Blood Proteins; Body Wei	1969
Diphenylhydantoin effect on neonatal and adult rat hepatic drug metabolism. The Journal of pharmacology and experimental therapeutics, 1970, Volume: 171, Issue:1 Topics: Age Factors; Aminopyrine; Aniline Compounds; Animals; Animals, Newborn; Benzoates; Benzopyrenes; Ben	1970
[Phenytoin intoxication--an insidous complication in the treatment of epilepsy]. Duodecim; laaketieteellinen aikakauskirja, 1970, Volume: 86, Issue:17 Topics: Adult; Body Weight; Cerebellar Diseases; Child; Epilepsy; Female; Humans; Male; Movement Disorders;	1970
Effect of phenobarbital and SKF 525A pretreatment on diphenylhydantoin teratogenicity in mice. The Journal of pharmacology and experimental therapeutics, 1970, Volume: 175, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Depression, Chemical; Drug Synergism; Female; Fet	1970
Amino acid composition of the Ammon's horn and the effect of anticonvulsant drugs. Acta physiologica Academiae Scientiarum Hungaricae, 1967, Volume: 32, Issue:4 Topics: Amino Acids; Animals; Anticonvulsants; Body Weight; Brain Chemistry; Chromatography, Paper; DNA; Hip	1967
[The necessary dosis of antiepileptic drugs in epileptic children during their growth period]. Der Nervenarzt, 1968, Volume: 39, Issue:6 Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Body Weight; Child; Child Development; Child, Pres	1968
The effect of 5,5-diphenylhydantoin on the rat uterus and its fetuses. Archives internationales de pharmacodynamie et de therapie, 1968, Volume: 175, Issue:1 Topics: Animals; Body Weight; Collagen; Female; Fetal Death; Fetus; Hydroxyproline; Nitrogen; Organ Size; Ph	1968

phenytoin and Body Weight

Research Excerpts

Research

Studies (165)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Flaherty, PT	1
Greenwood, TD	1
Manheim, AL	1
Wolfe, JF	1
Keats, K	1
Powell, R	1
Rocker, J	1
Waller, J	1
Coppiano, LS	1
Sathe, AG	1
Elm, JJ	1
Cloyd, JC	1
Chamberlain, JM	1
Silbergleit, R	1
Kapur, J	1
Cock, HR	1
Fountain, NB	1
Shinnar, S	1
Lowenstein, DH	1
Conwit, RA	1
Bleck, TP	1
Coles, LD	1
Guk, J	1
Lee, SG	1
Chae, D	1
Kim, JH	1
Park, K	1
Kane, SP	1
Bress, AP	1
Tesoro, EP	1
Takeuchi, M	1
Yano, I	1
Ito, S	1
Sugimoto, M	1
Yamamoto, S	1
Yonezawa, A	1
Ikeda, A	1
Matsubara, K	1
Fukuoka, N	1
Uno, J	1
Tsukamoto, T	1
Houchi, H	1
Kimura, M	1
Morita, S	1
Osuagwu, FC	1
Owoeye, O	1
Avwioro, OG	1
Oluwadara, OO	1
Imosemi, IO	1
Ajani, RS	1
Ogunleye, AA	1
Oladejo, OW	1
Mariotti, V	1
Melissari, E	1
Amar, S	1
Conte, A	1
Belmaker, RH	1
Agam, G	1
Pellegrini, S	1
Soysal, H	1
Unur, E	1
Düzler, A	1
Karaca, O	1
Ekinci, N	1
Punyawudho, B	1
Ramsay, ER	1
Brundage, RC	1
Macias, FM	1
Collins, JF	1
Birnbaum, AK	1
May, TW	2
Boor, R	1
Mayer, T	1
Jürgens, U	2
Rambeck, B	3
Holert, N	1
Korn-Merker, E	1
Brandt, C	1
Kim, SH	2
Lee, IC	1
Baek, HS	1
Lim, JH	1
Moon, C	1
Shin, DH	1
Park, SC	1
Kim, JC	1
Ogura, H	1
Yasuda, M	1
Nakamura, S	1
Yamashita, H	1
Mikoshiba, K	1
Ohmori, H	1
Birnbaum, A	1
Hardie, NA	1
Leppik, IE	1
Conway, JM	1
Bowers, SE	1
Lackner, T	1
Graves, NM	1
Kanamori, M	1
Takahashi, H	1
Echizen, H	1
Ujházy, E	1
Mach, M	1
Dubovický, M	1
Navarová, J	1
Soltés, L	1
Juránek, I	1
Brucknerová, I	1
Zeman, M	1
Jiao, Z	1
Shi, XJ	1
Zhao, ZG	1
Zhong, MK	1
Abela, D	1
Howe, AM	1
Oakes, DA	1
Webster, WS	1
Khaksary Mahabady, M	1
Ranjbar, R	1
Arzi, A	1
Papahn, AA	1
Najafzadeh, H	1
Staple, PH	2
Houck, JC	2
Nutter, DJ	1
Garzón, P	2
López-Ortega, G	2
Sandoval-Rojas, S	2
Mora-Galindo, J	1
Bastidas-Ramírez, BE	1
Navarro-Ruiz, A	1
Gascon-Barré, M	2
Delvin, EE	1
Glorieux, FH	1
Côté, MG	2
Oikarinen, J	1
Young, RA	2
Braverman, LE	2
Rajatanavin, R	2
Huon, GF	1
Brown, LB	1
Addy, V	1
McElnay, JC	1
Eyre, DG	1
Campbell, N	1
D'Arcy, PF	1
Mullenix, P	1
Tassinari, MS	2
Keith, DA	2
Tesseromatis, C	1
Galanopoulou, P	1
Varonos, D	1
Mimaki, T	1
Walson, PD	2
Haussler, MR	1
Gray, SP	1
Navarro, A	1
Dodson, WE	1
Loney, LC	1
Yokochi, K	1
Yokochi, A	1
Chiba, K	1
Ishizaki, T	1
Anisimov, VN	1
Entrikin, RK	1
Patterson, GT	1
Wilson, BW	1
McDevitt, JM	1
Gautieri, RF	2
Mann, DE	2
Blain, PG	1
Mucklow, JC	1
Bacon, CJ	1
Rawlins, MD	2
Tongia, SK	1
Leuschner, U	1
Walther, H	1
High, KA	1
Kubow, S	1
Burger, DM	1
Meenhorst, PL	1
Mulder, JW	1
Kraaijeveld, CL	1
Koks, CH	1
Bult, A	1
Beijnen, JH	1
Ismail, R	2
Rahman, AF	2
Chand, P	1
Bloksma, N	2
de Bakker, JM	1
van Rooijen, HJ	2
Punt, P	1
Seinen, W	2
Kammüller, ME	2
Diwan, BA	1
Henneman, JR	1
Nims, RW	1
Rice, JM	1
Patrini, C	1
Perucca, E	1
Reggiani, C	1
Rindi, G	1
Chhabra, RS	1
Bucher, JR	1
Haseman, JK	1
Elwell, MR	1
Kurtz, PJ	1
Carlton, BD	1
Shah, BS	1
Ratner, H	1
Magariños, AM	1
McEwen, BS	2
Flügge, G	1
Fuchs, E	1
Hartsfield, JK	1
Holmes, LB	1
Morel, JG	1
Valodia, P	1
Seymour, MA	1
Miller, R	1
McFadyen, ML	1
Folb, PI	1
Tiboni, GM	1
Iammarrone, E	1
Giampietro, F	1
Lamonaca, D	1
Bellati, U	1
Di Ilio, C	1
Fleishaker, JC	1
Fiedler-Kelly, J	1
Grasela, TH	1
Farombi, EO	1
Akinloye, O	1
Akinmoladun, CO	1
Emerole, GO	1
Hogan, RE	1
Bertrand, ME	1
Deaton, RL	1
Sommerville, KW	1
Sinz, EH	1
Kofke, WA	1
Garman, RH	1
Onodera, K	1
Takahashi, A	1
Mayanagi, H	1
Wakabayashi, H	1
Kamei, J	1
Shinoda, H	1
Sandström, M	1
Karlsson, MO	1
Ljungman, P	1
Hassan, Z	1
Jonsson, EN	1
Nilsson, C	1
Ringden, O	1
Oberg, G	1
Bekassy, A	1
Hassan, M	1
Ayers, GJ	1
Goudie, JH	1
Burnett, D	1
Sotaniemi, S	1
Villareale, ME	1
Chiroff, RT	2
Bergstrom, WH	2
Gould, LV	2
Wasserman, RH	2
Romano, FA	1
Gralla, EJ	1
Sabo, JP	1
Hayden, DW	1
Yochmowitz, MG	1
Mattsson, JL	1
Robinson, PB	1
Rowe, DJ	1
Harris, M	1
Foss, MC	1
Veríssimo, JM	1
Wermuth, BM	1
Davis, KL	1
Hollister, LE	1
Stunkard, AJ	1
Rau, JH	2
Struve, FA	1
Green, RS	2
Workman, P	1
Mitala, JJ	1
Singh, BN	1
Gaarder, TD	1
Kanegae, T	1
Goldstein, M	1
Montgomerie, JZ	1
Mills, H	1
Barot, MH	1
Grant, RH	1
Maheendran, KK	1
Mawer, GE	1
Woodcock, BG	1
Hassan, MN	1
Laljee, HC	1
Parsonage, MJ	1
Sofia, RD	1
Barry, H	1
Curless, RG	1
Carter, DE	1
Bäckström, T	1
Polin, D	1
Ringer, RK	1
Davis, HL	1
Bailey, DG	1
Johnson, GE	1
Wilson, TW	1
Hughes, FB	1
Simon, JL	1
Gugler, R	1
Shoeman, DW	1
Huffman, DH	1
Cohlmia, JB	1
Azarnoff, DL	1
Miller, RP	1
Becker, BA	6
Bosl, R	1
Shideman, JR	1
Meyer, RM	1
Buselmeier, TJ	1
von Hartitzsch, B	1
Kjellstrand, CM	1
Nolte, R	1
Brügmann, G	1
Besch, W	1
Lewis, JS	1
Bunker, ML	1
Getts, SS	1
Essien, R	1
Miller, WA	1
Barden, HS	1
Smith, E	1
Gut, I	1
Dil'man, VM	1
Bershteĭn, LM	1
Tsyrlina, EV	1
Bobrov, IuF	1
Kovaleva, IG	1
Houghton, GW	1
Richens, A	1
Leighton, M	1
Müller-Stüler, M	1
Nhachi, CF	1
Mwaluko, GM	1
Watanabe, Y	1
Gould, E	1
Cameron, HA	1
Daniels, DC	1
Liao, K	1
Seifter, E	1
Factor, SM	1
Yellin, EL	1
Frater, RW	1
Finnell, RH	2
Buehler, BA	1
Kerr, BM	1
Ager, PL	1
Levy, RH	2
Dowson, JH	1
Wilton-Cox, H	1
James, NT	1
Yukawa, E	1
Higuchi, S	3
Aoyama, T	3
Orr, RA	1
Dimand, RJ	1
Venkataraman, ST	1
Karr, VA	1
Kennedy, KJ	1
De Sandro, V	1
Chevrier, M	1
Boddaert, A	1
Melcion, C	1
Cordier, A	1
Richert, L	1
Theodoropoulos, TJ	1
Pappolla, MA	1
Goussis, OS	1
Zolman, JC	1
Benson, DM	1
Rowland, JR	1
Binkerd, PE	1
Hendrickx, AG	1
Chan, E	1
Ti, TY	1
Lee, HS	1
Ichikou, N	1
Ieiri, I	2
Hirata, K	2
Yamada, H	2
Abbott, LC	1
Taylor, SM	1
Singh, M	1
Shah, GL	1
el-Sayed, YM	1
Islam, SI	1
Wong, M	1
Helston, LM	1
Wells, PG	1
Zengel, AE	1
Glueck, CJ	1
Sucheston, ME	1
Hayes, TG	1
Eluma, FO	1
Moring, AF	1
Ohchi, H	1
Kusuhara, T	1
Katayama, T	1
Ohara, K	1
Kato, N	1
Maeda, T	1
Sano, N	1
Togei, K	1
Shibata, M	1
Izumi, K	1
Otsuka, H	1
Jang, JJ	1
Takahashi, M	1
Furukawa, F	1
Toyoda, K	1
Hasegawa, R	1
Sato, H	1
Hayashi, Y	1
Shapiro, BH	3
Babalola, GO	1
Johnson, GL	1
Ehrreich, SJ	1
el-Hage, AN	1
Balazs, T	1
Lech, GM	2
Bardales, RM	2
Ojemann, LM	1
Shastri, RA	1
Wilensky, AJ	1
Friel, PN	1
McLean, JR	1
Buchanan, RA	1
Vorhees, CV	1
Kuebel, MA	1
Yeager, VL	1
Taylor, JJ	1
Turnbull, DM	1
Howel, D	1
Chadwick, DW	1
May, T	1
Lai, ML	1
Yu, DK	1
Elmquist, WF	1
Sawchuk, RJ	1
Dubick, MA	1
Keen, CL	1
Gauchel, FD	1
Lehr, HJ	1
Gauchel, G	1
von Harnack, GA	1
Bonollo, L	1
De Hesse, C	1
Jacob, R	1
Platt, DS	1
Cockrill, BL	1
Villareale, M	1
Barr, A	1
Kraft, D	2
von Herrath, D	2
Schaefer, K	2
Hooshmand, H	1
Koski, CL	1
Rifenberick, DH	1
Max, SR	1
Hooper, WD	2
Tyrer, JH	2
Eadie, MJ	2
Albert, KS	1
Sakmar, E	1
Hallmark, MR	1
Weidler, DJ	1
Wagner, JG	1
Atkinson, AJ	1
Bergström, K	1
Blomstrand, R	1
Jacobson, S	1
Selye, H	1
Bishara, RH	1
Born, GS	1
Anderson, VL	1
Christian, JE	1
Van Arman, CG	1
Nuss, GW	1
Risley, EA	1
Gudmundson, C	1
Lidgren, L	1
Cook, RM	1
De Negrotto, OV	1
de Oxandabarat, MR	1
Negrotto, A	1
Monti, J	1
Dalmás, JF	1
Balea, E	1
Puppo, A	1
Kuenzel, WJ	1
Rubenstein, JB	1
Stambaugh, JE	1
Tucker, DC	1
Sholiton, LJ	1
Werk, EE	1
MacGee, J	1
Harbison, RD	4
Borofsky, LG	1
Louis, S	1
Kutt, H	1
Roginsky, M	1
Vapaatalo, H	1
Lehtinen, L	1
Markkanen, T	1
Peltola, O	1
Himanen, P	1
Riekkinen, P	1
Babcock, JR	1
Okabe, Y	1
Iizuka, H	1
Asahi, K	1
Yanagida, T	1
Eling, TE	1
Fouts, JR	1
Iivanainen, M	1
Viukari, M	1
Endröczi, E	1
Fekete, T	1
Breuer, U	1
Lempp, R	1
Gabler, WL	1