phenytoin has been researched along with Bipolar Disorder in 31 studies
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A potential model for bipolar disorder, quinpirole-induced biphasic locomotion, was used for a preliminary evaluation of behavioral effects of oral anticonvulsant treatment." | 7.71 | Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder. ( Belmaker, RH; Einat, H; Shaldubina, A; Shimon, H; Szechtman, H, 2002) |
| "Phenytoin is an effective anticonvulsant that has not previously been studied prophylactically in bipolar (BP) patients." | 6.71 | Prophylactic effect of phenytoin in bipolar disorder: a controlled study. ( Bersudsky, Y; Mishory, A; Winokur, M, 2003) |
| "He also had visual hallucinations and temporary high blood pressure." | 5.37 | Pharmacoresistant convulsions and visual hallucinations around two weeks after selegiline overdose: a case report. ( Kato, S; Kobayashi, T; Saito, N; Shioda, K; Suda, S, 2011) |
| " Three groups of patients were studied: (A) epileptic under phenytoin monotherapy (n = 31); (B) with bipolar disorder under valproic acid treatment (n = 28); (C) elderly (n = 41)." | 5.22 | Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia. ( Fagiolino, P; González, R; Guevara, N; Maldonado, C; Queijo, C; Vázquez, M, 2016) |
| "Phenytoin, a classical anticonvulsant has been little studied in bipolar disorder." | 5.12 | Phenytoin: an anti-bipolar anticonvulsant? ( Bersudsky, Y, 2006) |
| " This study demonstrated that the potent cytochrome P450 enzyme-inducer phenytoin did indeed have a marked effect on the metabolism of quetiapine, resulting in a 5-fold increase in clearance when administered concomitantly to patients with DSM-IV-diagnosed schizophrenia, schizoaffective disorder, or bipolar disorder." | 5.09 | The effects of concomitant phenytoin administration on the steady-state pharmacokinetics of quetiapine. ( Thyrum, PT; Wong, YW; Yeh, C, 2001) |
| "Starting with carbamazepine and valproate in the eighties, several anticonvulsant have been established as a treatment option in bipolar disorder." | 4.84 | [Anticonvulsants in the treatment of bipolar disorder]. ( Grunze, H, 2007) |
| "Preliminary clinical trials have recently shown that phenytoin, an antiepileptic drug, may also be beneficial for treatment of bipolar disorder." | 3.76 | Effect of prolonged phenytoin administration on rat brain gene expression assessed by DNA microarrays. ( Agam, G; Amar, S; Belmaker, RH; Conte, A; Mariotti, V; Melissari, E; Pellegrini, S, 2010) |
| "A potential model for bipolar disorder, quinpirole-induced biphasic locomotion, was used for a preliminary evaluation of behavioral effects of oral anticonvulsant treatment." | 3.71 | Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder. ( Belmaker, RH; Einat, H; Shaldubina, A; Shimon, H; Szechtman, H, 2002) |
| "Phenytoin is an effective anticonvulsant that has not previously been studied prophylactically in bipolar (BP) patients." | 2.71 | Prophylactic effect of phenytoin in bipolar disorder: a controlled study. ( Bersudsky, Y; Mishory, A; Winokur, M, 2003) |
| "Agents introduced for the treatment of epilepsy have also been usedsimultaneously for psychiatric indications." | 2.43 | [Anticonvulsants treatment of psychiatric disorder in elderly patients]. ( Bidzan, L, 2006) |
| "Carbamazepine was used as a positive control." | 1.39 | The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels. ( Andreatini, R; Biojone, C; Casarotto, PC; Correia, D; Guimarães, FS; Joca, SL; Martynhak, BJ; Pereira, M; Siba, IP; Tonelli, DA, 2013) |
| "He also had visual hallucinations and temporary high blood pressure." | 1.37 | Pharmacoresistant convulsions and visual hallucinations around two weeks after selegiline overdose: a case report. ( Kato, S; Kobayashi, T; Saito, N; Shioda, K; Suda, S, 2011) |
| "Eating disorders are commonly associated with depressive symptoms." | 1.35 | Treatment emergent mania responding to valproate in a Chinese female adolescent population with eating disorders: a case series. ( Lee, EL; Tor, PC, 2008) |
| "Thus it is necessary to rule out ictal catatonia by electroencephalography in patients with catatonic stupor." | 1.33 | Epileptic seizures superimposed on catatonic stupor. ( Awata, S; Ebina, Y; Honda, T; Matsuoka, H; Miura, N; Shindo, T; Suzuki, K; Takano, T, 2006) |
| "One of the leading causes of hypersomnia is sleep apnea." | 1.31 | Influence of chronic barbiturate administration on sleep apnea after hypersomnia presentation: case study. ( Bishop, J; Takhar, J, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (22.58) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 14 (45.16) | 29.6817 |
| 2010's | 6 (19.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Keppel Hesselink, JM | 1 |
| Tonelli, DA | 1 |
| Pereira, M | 1 |
| Siba, IP | 1 |
| Martynhak, BJ | 1 |
| Correia, D | 1 |
| Casarotto, PC | 1 |
| Biojone, C | 1 |
| Guimarães, FS | 1 |
| Joca, SL | 1 |
| Andreatini, R | 1 |
| Maldonado, C | 1 |
| Guevara, N | 1 |
| Queijo, C | 1 |
| González, R | 1 |
| Fagiolino, P | 1 |
| Vázquez, M | 1 |
| Tor, PC | 1 |
| Lee, EL | 1 |
| Bourin, M | 1 |
| Chenu, F | 1 |
| Hascoët, M | 1 |
| Mariotti, V | 1 |
| Melissari, E | 1 |
| Amar, S | 1 |
| Conte, A | 1 |
| Belmaker, RH | 4 |
| Agam, G | 1 |
| Pellegrini, S | 1 |
| Kobayashi, T | 1 |
| Saito, N | 1 |
| Suda, S | 1 |
| Shioda, K | 1 |
| Kato, S | 1 |
| Applebaum, J | 1 |
| Levine, J | 1 |
| Mishory, A | 2 |
| Winokur, M | 1 |
| Bersudsky, Y | 3 |
| Yatham, LN | 1 |
| Gallagher, P | 1 |
| Reid, KS | 1 |
| Watson, S | 1 |
| Suzuki, K | 1 |
| Miura, N | 1 |
| Awata, S | 1 |
| Ebina, Y | 1 |
| Takano, T | 1 |
| Honda, T | 1 |
| Shindo, T | 1 |
| Matsuoka, H | 1 |
| Bidzan, L | 1 |
| Grunze, H | 1 |
| Post, RM | 2 |
| Uhde, TW | 2 |
| Berrettini, W | 1 |
| Kellner, C | 1 |
| Aron, DC | 1 |
| Tyrrell, JB | 1 |
| Fitzgerald, PA | 1 |
| Findling, JW | 1 |
| Forsham, PH | 1 |
| Campbell, M | 1 |
| Cueva, JE | 1 |
| Yaroslavsky, Y | 1 |
| Takhar, J | 1 |
| Bishop, J | 1 |
| Janowsky, DS | 1 |
| Wong, YW | 1 |
| Yeh, C | 1 |
| Thyrum, PT | 1 |
| Shaldubina, A | 1 |
| Einat, H | 1 |
| Szechtman, H | 1 |
| Shimon, H | 1 |
| Hellekson, C | 1 |
| Buckland, R | 1 |
| Price, T | 1 |
| Diukov, VA | 1 |
| Dickson, LR | 1 |
| Miller, WH | 1 |
| Hyatt, MC | 1 |
| Dommisse, J | 1 |
| Patten, SB | 1 |
| Klein, GM | 1 |
| Lussier, C | 1 |
| Sawa, R | 1 |
| Keitner, GI | 1 |
| Fruzzetti, AE | 1 |
| Miller, IW | 1 |
| Norman, WH | 1 |
| Brown, WA | 1 |
8 reviews available for phenytoin and Bipolar Disorder
| Article | Year |
|---|---|
Phenytoin repositioned in wound healing: clinical experience spanning 60 years.
Topics: Administration, Topical; Bipolar Disorder; Chemistry, Pharmaceutical; Drug Repositioning; Humans; Ne | 2018 |
Newer anticonvulsants in the treatment of bipolar disorder.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Dep | 2004 |
[Anticonvulsants treatment of psychiatric disorder in elderly patients].
Topics: Aged; Anticonvulsants; Anxiety Disorders; Bipolar Disorder; Carbamazepine; Epilepsy; Humans; Mental | 2006 |
[Anticonvulsants in the treatment of bipolar disorder].
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Drug T | 2007 |
Treatment of mood disorders with antiepileptic medications: clinical and theoretical implications.
Topics: Anticonvulsants; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Clonazepam; Depressive D | 1983 |
Psychopharmacology in child and adolescent psychiatry: a review of the past seven years. Part II.
Topics: Adolescent; Alprazolam; Anticonvulsants; Antipsychotic Agents; Anxiety, Separation; Bipolar Disorder | 1995 |
New treatments of bipolar disorder.
Topics: Acetates; Amines; Anticonvulsants; Antimanic Agents; Benzodiazepines; Bipolar Disorder; Clinical Tri | 1999 |
[Pharmacogenetic research in clinical psychiatry].
Topics: Antidepressive Agents, Tricyclic; Biotransformation; Bipolar Disorder; Chlorpromazine; Cholinesteras | 1976 |
7 trials available for phenytoin and Bipolar Disorder
| Article | Year |
|---|---|
Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia.
Topics: Acetylcarnitine; Adolescent; Adult; Aged; Aged, 80 and over; Ammonia; Bipolar Disorder; Carnitine; E | 2016 |
Prophylactic effect of phenytoin in bipolar disorder: a controlled study.
Topics: Anticonvulsants; Bipolar Disorder; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Mi | 2003 |
Phenytoin: an anti-bipolar anticonvulsant?
Topics: Anticonvulsants; Bipolar Disorder; Double-Blind Method; Humans; Phenytoin | 2006 |
Treatment of mood disorders with antiepileptic medications: clinical and theoretical implications.
Topics: Anticonvulsants; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Clonazepam; Depressive D | 1983 |
Selective response to the anticonvulsant carbamazepine in manic-depressive illness: a case study.
Topics: Bipolar Disorder; Carbamazepine; Dose-Response Relationship, Drug; Female; Humans; Lithium; Middle A | 1984 |
Phenytoin as an antimanic anticonvulsant: a controlled study.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Brief Psychiatric Rating Scale; Double-Blind Me | 2000 |
The effects of concomitant phenytoin administration on the steady-state pharmacokinetics of quetiapine.
Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Di | 2001 |
17 other studies available for phenytoin and Bipolar Disorder
| Article | Year |
|---|---|
The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Carbamazepine; Disease Models, Animal; Dose-Response Re | 2013 |
Treatment emergent mania responding to valproate in a Chinese female adolescent population with eating disorders: a case series.
Topics: Adolescent; Anorexia Nervosa; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Bulimia Nervosa; | 2008 |
Topiramate and phenytoin anti-immobility effect in the mice forced swimming test is reversed by veratrine: Implication for bipolar depression treatment.
Topics: Animals; Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Disease Models, Animal; Dose- | 2009 |
Effect of prolonged phenytoin administration on rat brain gene expression assessed by DNA microarrays.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Body Weight; Brain; Disease Models, Animal; Frontal Lob | 2010 |
From the clinics to the bench and back - phenytoin as a mood stabilizer?
Topics: Affect; Animals; Antimanic Agents; Bipolar Disorder; Drug Design; Drug Evaluation, Preclinical; Fron | 2010 |
Pharmacoresistant convulsions and visual hallucinations around two weeks after selegiline overdose: a case report.
Topics: Anticonvulsants; Bipolar Disorder; Coma; Diazepam; Drug Overdose; Drug Resistance; Hallucinations; H | 2011 |
Intravenous fosphenytoin in acute mania.
Topics: Acute Disease; Adult; Bipolar Disorder; Drug Administration Schedule; Female; Humans; Infusions, Int | 2003 |
Phenytoin, an anti-bipolar anticonvulsant: a potential anti-glucocorticoid mechanism?
Topics: Anticonvulsants; Bipolar Disorder; Glucocorticoids; Humans; Phenytoin | 2006 |
Epileptic seizures superimposed on catatonic stupor.
Topics: Aged; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Catatonia; Combined Modality Therapy; | 2006 |
Cushing's syndrome: problems in diagnosis.
Topics: ACTH Syndrome, Ectopic; Adenoma; Adrenal Cortex Function Tests; Adrenocortical Hyperfunction; Adult; | 1981 |
Influence of chronic barbiturate administration on sleep apnea after hypersomnia presentation: case study.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Disorders of Excessive Somnolence; Dose-Response Relations | 2000 |
Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder.
Topics: Administration, Oral; Animals; Anticonvulsants; Bipolar Disorder; Brain; Carbamazepine; Disease Mode | 2002 |
Organic personality disturbance: a case of apparent atypical cyclic affective disorder.
Topics: Adult; Bipolar Disorder; Carbamazepine; Electroencephalography; Epilepsy, Temporal Lobe; Female; Hum | 1979 |
Pregnancy complicated by acute mania and preeclampsia.
Topics: Acute Disease; Adult; Bipolar Disorder; Female; Humans; Lithium; Phenytoin; Pre-Eclampsia; Pregnancy | 1992 |
Organic mania induced by phenytoin.
Topics: Bipolar Disorder; Humans; Neurocognitive Disorders; Phenytoin; Vitamin B 12 Deficiency | 1990 |
Organic mania induced by phenytoin: a case report.
Topics: Aged; Bipolar Disorder; Cerebral Infarction; Epilepsies, Partial; Female; Humans; Mental Status Sche | 1989 |
The effect of anticonvulsants on the dexamethasone suppression test.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Carbamazepine; Depressive Disorder; Dexamethasone; Epileps | 1989 |