phenytoin and Benign Supratentorial Neoplasms studies

Research Excerpts

Excerpt	Relevance	Reference
" Therefore, the authors conducted a prospective, randomized trial examining the use of phenytoin for postoperative seizure prophylaxis in patients undergoing resection for supratentorial brain metastases or gliomas."	5.17	A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors. ( Forman, A; Graham, S; Heimberger, AB; Hess, K; Lang, FF; McCutcheon, IE; Prabhu, SS; Qiao, W; Sawaya, R; Suki, D; Trinh, VT; Wang, X; Weinberg, JS; Wu, AS, 2013)
" The lack of consensus on prophylaxis of early postoperative seizures with phenytoin (PHT) may be due to the different dosages used in several studies, owing to inadequate therapeutic plasma level."	5.08	Peri-operative prophylaxis with phenytoin: dosage and therapeutic plasma levels. ( Boselli, L; Levati, A; Savoia, G; Tommasino, C; Zoppi, F, 1996)
"Both levetiracetam (LEV) and phenytoin (PHT) were associated with a low risk of early postoperative seizures and a moderate risk of later epilepsy."	3.74	Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery. ( Bromfield, EB; Hurwitz, S; Milligan, TA, 2008)
"Gabapentin is an anticonvulsant drug that has analgesic properties for acute postoperative pain."	2.74	The analgesic effect of gabapentin as a prophylactic anticonvulsant drug on postcraniotomy pain: a prospective randomized study. ( Aykac, B; Bingol, CA; Karlikaya, G; Sayin, M; Türe, H; Türe, U, 2009)
"Use of seizure prophylaxis following intracranial biopsies and supratentorial resections is highly variable, consistent with a lack of guidelines or consensus."	1.56	Patterns of seizure prophylaxis after oncologic neurosurgery. ( Bruce, JN; Hershman, DL; Joiner, EF; McKhann, GM; Neugut, AI; Wang, X; Welch, MR; Wright, JD; Yang, J; Youngerman, BE, 2020)
"Perioperative seizure prophylaxis with antiepileptic drugs (AED) has been advocated in patients undergoing supratentorial craniotomy."	1.48	The risk of hypotension and seizures in patients receiving prophylactic anti-epileptic drugs for supratentorial craniotomy. ( Brawanski, A; Höhne, J; Lange, M; Ott, C; Schebesch, KM, 2018)
"Bilirubin levels were normal."	1.35	The effects of propofol infusion on hepatic and pancreatic function and acid-base status in children undergoing craniotomy and receiving phenytoin. ( Aykac, B; Koner, O; Mercan, A; Türe, H; Türe, U, 2009)
"Levetiracetam was more likely to be used in children who received chemotherapy or radiation therapy (8/14, or 57%) than in those who did not receive adjuvant therapies (3/18, or 17%) (P = 0."	1.35	The use of antiepileptic drugs in pediatric brain tumor patients. ( Kan, L; Levy, AS; Maytal, J; Shinnar, S; Sogawa, Y, 2009)
" Pharmacokinetic and pharmacodynamic modeling was used to characterize the disposition of vecuronium and patient responses to it in the two groups."	1.32	Influence of chronic phenytoin administration on the pharmacokinetics and pharmacodynamics of vecuronium. ( Caldwell, JE; McCarthy, G; Sharma, ML; Szenohradszky, J; Wright, PM, 2004)

Research

Studies (13)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

"VAS Score 1: How Much Pain do You Feel in Your Operative Site When Resting?"

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (7.69)	18.2507
2000's	7 (53.85)	29.6817
2010's	4 (30.77)	24.3611
2020's	1 (7.69)	2.80

Authors	Studies
Youngerman, BE	1
Joiner, EF	1
Wang, X	2
Yang, J	1
Welch, MR	1
McKhann, GM	1
Wright, JD	1
Hershman, DL	1
Neugut, AI	1
Bruce, JN	1
Pourzitaki, C	1
Tsaousi, G	1
Apostolidou, E	1
Karakoulas, K	1
Kouvelas, D	1
Amaniti, E	1
Liang, S	1
Zhang, J	1
Zhang, S	1
Fu, X	1
Höhne, J	1
Schebesch, KM	1
Ott, C	1
Brawanski, A	1
Lange, M	1
Milligan, TA	1
Hurwitz, S	1
Bromfield, EB	1
Türe, H	2
Mercan, A	1
Koner, O	1
Aykac, B	2
Türe, U	2
Sogawa, Y	1
Kan, L	1
Levy, AS	1
Maytal, J	1
Shinnar, S	1
Sayin, M	1
Karlikaya, G	1
Bingol, CA	1
Gottschalk, A	1
Wu, AS	1
Trinh, VT	1
Suki, D	1
Graham, S	1
Forman, A	1
Weinberg, JS	1
McCutcheon, IE	1
Prabhu, SS	1
Heimberger, AB	1
Sawaya, R	1
Qiao, W	1
Hess, K	1
Lang, FF	1
Wright, PM	1
McCarthy, G	1
Szenohradszky, J	1
Sharma, ML	1
Caldwell, JE	1
Radhakrishnan, M	1
Devaraj, ND	1
Umamaheswara Rao, GS	1
Subhash, MN	1
Levati, A	1
Savoia, G	1
Zoppi, F	1
Boselli, L	1
Tommasino, C	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903]	Phase 4	77 participants (Actual)	Interventional	2018-05-15	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)

"VAS Score 2: How Much Pain do You Feel in Your Operative Site When Moving?"

Intervention	score on 10-point scale (Mean)
Standard of Care	2.26
Postoperative Gabapentin Regimen	2.46

Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 3: How Well Are You Sleeping?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	3.84
Postoperative Gabapentin Regimen	3.54

Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 4: How Bad is Your Nausea?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	5.73
Postoperative Gabapentin Regimen	6.38

Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 5: How Satisfied Are You With Your Pain Management?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	0.36
Postoperative Gabapentin Regimen	0.17

Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Days Taking Opioids

Intervention	score on a 10-point scale (Mean)
Standard of Care	7.83
Postoperative Gabapentin Regimen	8.48

Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Opioid Consumption

Intervention	days (Mean)
Standard of Care	14.8
Postoperative Gabapentin Regimen	18.7

Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).

Article	Year
The analgesic effect of gabapentin as a prophylactic anticonvulsant drug on postcraniotomy pain: a prospective randomized study. Anesthesia and analgesia, 2009, Volume: 109, Issue:5 Topics: Administration, Oral; Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid;	2009
A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors. Journal of neurosurgery, 2013, Volume: 118, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Bayes Theorem; Brain Neoplasms; Craniot	2013
Peri-operative prophylaxis with phenytoin: dosage and therapeutic plasma levels. Acta neurochirurgica, 1996, Volume: 138, Issue:3 Topics: Adult; Aged; Anticonvulsants; Cefazolin; Dexamethasone; Drug Interactions; Drug Therapy, Combination	1996

Article	Year
Patterns of seizure prophylaxis after oncologic neurosurgery. Journal of neuro-oncology, 2020, Volume: 146, Issue:1 Topics: Adolescent; Adult; Anticonvulsants; Brain Neoplasms; Craniotomy; Female; Follow-Up Studies; Humans;	2020
Epilepsy in Adults with Supratentorial Glioblastoma: Incidence and Influence Factors and Prophylaxis in 184 Patients. PloS one, 2016, Volume: 11, Issue:7 Topics: Adult; Aged; Anticonvulsants; Craniotomy; Epilepsy; Female; Frontal Lobe; Glioblastoma; Humans; Male	2016
The risk of hypotension and seizures in patients receiving prophylactic anti-epileptic drugs for supratentorial craniotomy. Journal of neurosurgical sciences, 2018, Volume: 62, Issue:4 Topics: Acetamides; Adult; Anticonvulsants; Blood Pressure; Craniotomy; Female; Humans; Hypotension; Lacosam	2018
Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery. Neurology, 2008, Aug-26, Volume: 71, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain; Brain Injuries; Drug Tolerance; Drug-Related	2008
The effects of propofol infusion on hepatic and pancreatic function and acid-base status in children undergoing craniotomy and receiving phenytoin. Anesthesia and analgesia, 2009, Volume: 109, Issue:2 Topics: Acid-Base Equilibrium; Analgesics, Opioid; Anesthetics, Intravenous; Anticonvulsants; Bilirubin; Blo	2009
The use of antiepileptic drugs in pediatric brain tumor patients. Pediatric neurology, 2009, Volume: 41, Issue:3 Topics: Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Carbamazepine; Child; Drug Interactions; Fo	2009
Craniotomy pain: trying to do better. Anesthesia and analgesia, 2009, Volume: 109, Issue:5 Topics: Administration, Oral; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anticon	2009
Influence of chronic phenytoin administration on the pharmacokinetics and pharmacodynamics of vecuronium. Anesthesiology, 2004, Volume: 100, Issue:3 Topics: Adult; Anticonvulsants; Biotransformation; Craniotomy; Drug Interactions; Female; Humans; Male; Midd	2004
Additional phenytoin is frequently needed in patients undergoing craniotomy for supratentorial tumour. European journal of anaesthesiology, 2008, Volume: 25, Issue:7 Topics: Adult; Craniotomy; Female; Humans; Male; Middle Aged; Phenytoin; Postoperative Complications; Suprat	2008

phenytoin and Benign Supratentorial Neoplasms