phenytoin and Benign Neoplasms, Brain studies

Research Excerpts

Excerpt	Relevance	Reference
"Seizures are common in patients with gliomas, and phenytoin (PHT) is frequently used to control tumor-related seizures."	9.14	Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. ( Barbaro, N; Burt, M; Chakalian, L; Chang, E; Chang, S; Lamborn, KR; Lim, DA; McDermott, MW; Tarapore, P, 2009)
" Approximately 30-40% of brain tumors patients who present with status epilepticus (SE) will not respond to typical therapy consisting of benzodiazepines and phenytoin (PHT), resulting in patients with refractory status epilepticus (RSE)."	7.78	Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors. ( Doreswamy, M; Gingrich, KJ; Kolls, BJ; Swisher, CB; Vredenburgh, JJ, 2012)
"A 46 year old male patient with metastatic prostate cancer developed Stevens-Johnson syndrome (SJS), initially in three well-demarcated areas on his scalp, chest and back, corresponding to ports of radiation therapy while on phenytoin."	7.76	Multifocal Stevens-Johnson syndrome after concurrent phenytoin and cranial and thoracic radiation treatment, a case report. ( Dvorak, T; Kandil, AO; Mignano, J; Wu, JK; Zhu, JJ, 2010)
"A case of erythema multiforme associated with prophylactic use of phenytoin during cranial radiation therapy is reported."	7.74	Erythema multiforme associated with prophylactic use of phenytoin during cranial radiation therapy. ( Barbosa, LA; Teixeira, CR, 2008)
"A 30-year-old man was given high doses of phenytoin together with 4 antituberculous drugs for a seizure associated with a probable brain tuberculoma."	7.70	[Residual cerebellar ataxia following acute phenytoin intoxication]. ( al Beladi, K; al Jumah, M; Amene, P; Awada, A, 1999)
"The action of the anticonvulsant drug phenytoin on K+ channels was investigated in neuroblastoma cells (N2A) by using the single-channel patch-clamp technique."	7.70	A discriminant block among K+ channel types by phenytoin in neuroblastoma cells. ( Lagostena, L; Nobile, M, 1998)
"Agranulocytosis is a rare side effect of phenytoin treatment."	7.68	Phenytoin-induced agranulocytosis: a nonimmunologic idiosyncratic reaction? ( McClune, GL; Sharafuddin, MJ; Spanheimer, RG, 1991)
" Eighteen patients had pharmacokinetic assays of Paclitaxel levels."	6.73	Fractionated stereotactic radiotherapy boost and weekly paclitaxel in malignant gliomas clinical and pharmacokinetics results. ( Ashamalla, H; Colella, F; Dosik, D; Guriguis, A; Krishnamurthy, M; Lavaf, A; Lewis, L; Mokhtar, B; Nasr, H; Saad, N; Zaki, B, 2007)
"Celecoxib (400) mg was administered orally twice a day until tumor progression or dose-limiting toxicity."	6.73	Effect of phenytoin on celecoxib pharmacokinetics in patients with glioblastoma. ( Batchelor, T; Desideri, S; Grossman, SA; Hammour, T; Lesser, G; Olson, J; Peereboom, D; Supko, JG; Ye, X, 2008)
" The radiation dosage in each group was equal to 1702 ret."	6.65	The Cambridge glioma trial of misonidazole and radiation therapy with associated pharmacokinetic studies. ( Bleehen, NM, 1980)
"Severe thrombocytopenia was managed first by transfusion of 17 units of platelets and by cessation of intravenous phenytoin plus the starting of 500 mg levetiracetam orally twice daily."	5.56	Phenytoin Seizure Prophylaxis Therapy Resulting in Severe Thrombocytopenia After Brain Tumor Debulking Surgery. ( Al Ghamdi, RM; Ben Ali, H; Turkistani, AN, 2020)
"To compare the incidence of seizures in patients receiving either prophylactic PHT or LEV perioperatively, 971 patients undergoing a craniotomy were analysed retrospectively during a 2-year period."	5.38	Levetiracetam compared to phenytoin for the prevention of postoperative seizures after craniotomy for intracranial tumours in patients without epilepsy. ( Brawanski, AT; Feigl, GC; Hansen, E; Kern, K; Lange, M; Schebesch, KM; Schlaier, J, 2012)
" The pooled data were analyzed using population pharmacokinetic (POP-PK) methods."	5.33	Population pharmacokinetics of motexafin gadolinium in adults with brain metastases or glioblastoma multiforme. ( Boswell, GW; Ford, JM; Hutcheson, SJ; Miles, DR; Phan, SC; Renschler, MF; Smith, JA, 2005)
"The population pharmacokinetic model reported here was developed using data from 2 phase 2 trials of irinotecan for treatment of malignant glioma to quantify the impact of concomitant therapy with enzyme-inducing antiepileptic drugs (EIAEDs) on irinotecan pharmacokinetics."	5.20	Quantification of the impact of enzyme-inducing antiepileptic drugs on irinotecan pharmacokinetics and SN-38 exposure. ( Ames, MM; Berg, AK; Buckner, JC; Galanis, E; Jaeckle, KA; Reid, JM, 2015)
" Therefore, the authors conducted a prospective, randomized trial examining the use of phenytoin for postoperative seizure prophylaxis in patients undergoing resection for supratentorial brain metastases or gliomas."	5.17	A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors. ( Forman, A; Graham, S; Heimberger, AB; Hess, K; Lang, FF; McCutcheon, IE; Prabhu, SS; Qiao, W; Sawaya, R; Suki, D; Trinh, VT; Wang, X; Weinberg, JS; Wu, AS, 2013)
"Seizures are common in patients with gliomas, and phenytoin (PHT) is frequently used to control tumor-related seizures."	5.14	Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. ( Barbaro, N; Burt, M; Chakalian, L; Chang, E; Chang, S; Lamborn, KR; Lim, DA; McDermott, MW; Tarapore, P, 2009)
"No evidence supports AED prophylaxis with phenobarbital, phenytoin, or valproic acid in patients with brain tumors and no history of seizures, regardless of neoplastic type."	4.82	Seizure prophylaxis in patients with brain tumors: a meta-analysis. ( Drazkowski, JF; Lyons, MK; Sirven, JI; Wingerchuk, DM; Zimmerman, RS, 2004)
"Erythema multiforme major (EMM; Stevens-Johnson syndrome) is a cutaneous disorder associated with a wide variety of factors including ingestion of drugs such as phenytoin and exposure to intracranial radiation therapy."	4.80	Increased risk of erythema multiforme major with combination anticonvulsant and radiation therapies. ( Han, N; Linthicum, K; Micali, G; West, DP, 1999)
"A 29-year-old white man with brain metastases secondary to malignant melanoma consistently had suboptimal phenytoin concentrations while receiving chemotherapy consisting of cisplatin, carmustine, dacarbazine, and tamoxifen."	4.79	Possible interaction involving phenytoin, dexamethasone, and antineoplastic agents: a case report and review. ( Gattis, WA; May, DB, 1996)
"Three recent publications have reported the development of erythema multiforme and Stevens-Johnson syndrome in patients receiving cranial irradiation and sodium phenytoin."	4.79	Is phenytoin contraindicated in patients receiving cranial irradiation? ( Borg, MF; Probert, JC; Zwi, LJ, 1995)
" Phenytoin is normally used to control intraoperative seizures."	4.02	Utility of monitoring the serum levetiracetam concentration for intraoperative seizure control during awake craniotomy. ( Kawaguchi, K; Kikuchi, M; Kushihara, Y; Otani, R; Shinoura, N; Yamada, R, 2021)
"We report the cases of 2 breast cancer patients who received capecitabine(CAP)and concomitant anticonvulsant therapy with either phenytoin(PHT)or valproate(VPA)for brain metastasis."	3.80	[Effect of capecitabine therapy on the blood levels of antiepileptic drugs - report of two cases]. ( Ibayashi, Y; Jotoku, H; Takahashi, M; Takasaki, M; Tanaka, H; Watanabe, K, 2014)
" Approximately 30-40% of brain tumors patients who present with status epilepticus (SE) will not respond to typical therapy consisting of benzodiazepines and phenytoin (PHT), resulting in patients with refractory status epilepticus (RSE)."	3.78	Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors. ( Doreswamy, M; Gingrich, KJ; Kolls, BJ; Swisher, CB; Vredenburgh, JJ, 2012)
"A 46 year old male patient with metastatic prostate cancer developed Stevens-Johnson syndrome (SJS), initially in three well-demarcated areas on his scalp, chest and back, corresponding to ports of radiation therapy while on phenytoin."	3.76	Multifocal Stevens-Johnson syndrome after concurrent phenytoin and cranial and thoracic radiation treatment, a case report. ( Dvorak, T; Kandil, AO; Mignano, J; Wu, JK; Zhu, JJ, 2010)
" Differentiated human neuroblastoma SH-SY5Y cells were exposed to acrylamide, lindane, parathion, paraoxon, phenytoin, diazepam or caffeine for 72 hours."	3.74	Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity. ( Blaauboer, B; Forsby, A, 2007)
"Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been associated with some drugs, particularly anticonvulsants such as phenytoin."	3.74	[Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy]. ( Fernández, FA; Garcés, FJ; Pintor, E; Quesada, R, 2007)
"A case of erythema multiforme associated with prophylactic use of phenytoin during cranial radiation therapy is reported."	3.74	Erythema multiforme associated with prophylactic use of phenytoin during cranial radiation therapy. ( Barbosa, LA; Teixeira, CR, 2008)
"Phenytoin is an anti-convulsant drug commonly used to prevent seizures in patients with cerebral metastases."	3.73	A case of phenytoin toxicity in a patient with advanced lung cancer. ( Jenkins, A, 2006)
"There are few reports about Stevens-Johnson syndrome, a bullous form of erythema multiforme, that can develop in patients treated with cranial irradiation and antiepileptic drugs, especially with phenytoin."	3.72	Toxic epidermal necrolysis after cranial radiotherapy and phenytoin treatment. ( Demirkesen, C; Koca, S; Oner Dincbas, F; Uzel, O; Yörük, S, 2004)
" The extensive involvement of the oral mucosa with conjunctivitis and synechiae of the eyelids, facial swelling, and extension of the rash over the trunk and shoulders with bullous detachment of less than 10% of the total body surface strongly suggested Stevens-Johnson syndrome caused by phenytoin treatment in our patient."	3.71	Stevens-Johnson syndrome in a patient receiving anticonvulsant therapy during cranial irradiation. ( Aydiner, A; Eralp, Y; Saip, P; Taş, F; Topuz, E, 2001)
"A 30-year-old man was given high doses of phenytoin together with 4 antituberculous drugs for a seizure associated with a probable brain tuberculoma."	3.70	[Residual cerebellar ataxia following acute phenytoin intoxication]. ( al Beladi, K; al Jumah, M; Amene, P; Awada, A, 1999)
"The action of the anticonvulsant drug phenytoin on K+ channels was investigated in neuroblastoma cells (N2A) by using the single-channel patch-clamp technique."	3.70	A discriminant block among K+ channel types by phenytoin in neuroblastoma cells. ( Lagostena, L; Nobile, M, 1998)
" High-dose tamoxifen was recently reported as a novel treatment for patients with malignant gliomas who have failed standard therapies."	3.69	High-dose tamoxifen in treatment of brain tumors: interaction with antiepileptic drugs. ( Couldwell, WT; Dyck, P; Hinton, DR; Rabinowicz, AL, 1995)
"Agranulocytosis is a rare side effect of phenytoin treatment."	3.68	Phenytoin-induced agranulocytosis: a nonimmunologic idiosyncratic reaction? ( McClune, GL; Sharafuddin, MJ; Spanheimer, RG, 1991)
"A 56-year-old man with a small glioblastoma multiforme in the right parasagittal region developed orofacial dyskinesia and slight writhing movement of his hands during treatment with phenytoin and phenobarbitone."	3.67	Phenytoin-induced orofacial dyskinesia. A case report. ( Nakanishi, T; Ozaki, Y; Yamada, S; Yoshida, M, 1985)
"Phenytoin (PHT) is routinely used for seizure prophylaxis in patients with brain tumours during and after craniotomy, despite incomplete evidence."	2.80	Levetiracetam versus phenytoin for seizure prophylaxis during and early after craniotomy for brain tumours: a phase II prospective, randomised study. ( Hasegawa, Y; Iuchi, T; Kawasaki, K; Kuwabara, K; Matsumoto, M; Sakaida, T, 2015)
" Eighteen patients had pharmacokinetic assays of Paclitaxel levels."	2.73	Fractionated stereotactic radiotherapy boost and weekly paclitaxel in malignant gliomas clinical and pharmacokinetics results. ( Ashamalla, H; Colella, F; Dosik, D; Guriguis, A; Krishnamurthy, M; Lavaf, A; Lewis, L; Mokhtar, B; Nasr, H; Saad, N; Zaki, B, 2007)
"Celecoxib (400) mg was administered orally twice a day until tumor progression or dose-limiting toxicity."	2.73	Effect of phenytoin on celecoxib pharmacokinetics in patients with glioblastoma. ( Batchelor, T; Desideri, S; Grossman, SA; Hammour, T; Lesser, G; Olson, J; Peereboom, D; Supko, JG; Ye, X, 2008)
"Seventy patients died (unrelated to seizures) and survival rates were equivalent in both groups (median survival = 6."	2.71	Prophylactic anticonvulsants in patients with brain tumour. ( Barnes, P; Brasher, PM; Cairncross, JG; DeAngelis, LM; Forsyth, PA; Fulton, D; Hagen, NA; Stewart, D; Sutherland, G; Weaver, S, 2003)
" Newly diagnosed patients with high-grade glioma received IFN-alpha2a at a dosage of 3 to 6 million IU s."	2.70	Interferon-alpha2a and 13-cis-retinoic acid with radiation treatment for high-grade glioma. ( Barth, NM; Church, CK; DePriest, C; Dillman, RO; Kharkar, BR; Mahdavi, K; Poor, MM; Shea, WM; Tai, DF, 2001)
" The radiation dosage in each group was equal to 1702 ret."	2.65	The Cambridge glioma trial of misonidazole and radiation therapy with associated pharmacokinetic studies. ( Bleehen, NM, 1980)
"The lifetime risk of having epileptic seizures is profoundly increased in patients with cancer: about 20% of all patients with systemic cancer may develop brain metastases."	2.48	Epilepsy meets cancer: when, why, and what to do about it? ( Stupp, R; Weller, M; Wick, W, 2012)
"The mainstay of treatment for seizures is medical therapy with antiepileptic drugs."	2.47	Antiepileptic drugs for treating seizures in adults with brain tumours. ( Grant, R; Kerrigan, S, 2011)
"The authors believe that diencephalic seizures can present with a spectrum of autonomic features, and treatment should be tailored with the appropriate pharmacologic blockade."	2.40	Sympathetic storms in a child with a midbrain glioma: a variant of diencephalic seizures. ( Conway, EJ; DaRosso, RC; Epstein, FJ; Goh, KY; Muszynski, CA, 1999)
" Serious consequences can be avoided by expecting changes in phenytoin dosage requirements after the administration of chemotherapy, monitoring serum levels frequently, and making appropriate adjustments in phenytoin dosages."	2.38	Decreased phenytoin levels in patients receiving chemotherapy. ( Gilbert, MR; Grossman, SA; Sheidler, VR, 1989)
"In this study brain tumors developing with tuberous sclerosis were biologically benign; total transcortical tumor removal permanently relieved the attending cerebral hypertension and achieved prolonged survival without notable functional impairment."	2.35	Brain tumors in hereditary multiple system hamartomatosis (tuberous sclerosis). ( Cooper, JR, 1971)
"Severe thrombocytopenia was managed first by transfusion of 17 units of platelets and by cessation of intravenous phenytoin plus the starting of 500 mg levetiracetam orally twice daily."	1.56	Phenytoin Seizure Prophylaxis Therapy Resulting in Severe Thrombocytopenia After Brain Tumor Debulking Surgery. ( Al Ghamdi, RM; Ben Ali, H; Turkistani, AN, 2020)
"Use of seizure prophylaxis following intracranial biopsies and supratentorial resections is highly variable, consistent with a lack of guidelines or consensus."	1.56	Patterns of seizure prophylaxis after oncologic neurosurgery. ( Bruce, JN; Hershman, DL; Joiner, EF; McKhann, GM; Neugut, AI; Wang, X; Welch, MR; Wright, JD; Yang, J; Youngerman, BE, 2020)
" Concomitant use of erlotinib and the antiepileptic drug phenytoin, an inducer of CYP3A4, may result in a drug-drug interaction accompanied by changes in the blood concentrations of both drugs."	1.43	Drug interaction between erlotinib and phenytoin for brain metastases in a patient with nonsmall cell lung cancer. ( Homma, M; Kaburagi, T; Kurosawa, A; Ohgami, M, 2016)
"Levetiracetam was very well tolerated."	1.42	Epilepsy in patients with gliomas: incidence and control of seizures. ( Hasegawa, Y; Iuchi, T; Kawasaki, K; Sakaida, T, 2015)
"Phenytoin was most commonly implicated (93 %) in rash formation compared with other AEDs (P < 0."	1.40	EMPACT syndrome: limited evidence despite a high-risk cohort. ( Barker, CA; Bishop, AJ; Chang, M; Lacouture, ME, 2014)
"53."	1.39	Considerations in prophylaxis for tumor-associated epilepsy: prevention of status epilepticus and tolerability of newer generation AEDs. ( Buniak, L; Henry, JC; Mohile, N; Wang, H; Wychowski, T, 2013)
"To compare the incidence of seizures in patients receiving either prophylactic PHT or LEV perioperatively, 971 patients undergoing a craniotomy were analysed retrospectively during a 2-year period."	1.38	Levetiracetam compared to phenytoin for the prevention of postoperative seizures after craniotomy for intracranial tumours in patients without epilepsy. ( Brawanski, AT; Feigl, GC; Hansen, E; Kern, K; Lange, M; Schebesch, KM; Schlaier, J, 2012)
"Phenytoin was the most common AED used (n = 4)."	1.38	A review of the use of antiepileptic drugs in high-grade central nervous system tumors. ( O'Reilly, M; Twomey, M; Wallace, EM, 2012)
"Cranial MRI revealed a right frontal cavernous hemangioma."	1.35	Refractory status epilepticus during pregnancy secondary to cavernous angioma. ( Aladdin, Y; Gross, DW, 2008)
"Levetiracetam was more likely to be used in children who received chemotherapy or radiation therapy (8/14, or 57%) than in those who did not receive adjuvant therapies (3/18, or 17%) (P = 0."	1.35	The use of antiepileptic drugs in pediatric brain tumor patients. ( Kan, L; Levy, AS; Maytal, J; Shinnar, S; Sogawa, Y, 2009)
"Brain metastases are a frequent finding in patients with advanced non-small cell lung cancer and concomitant administration of antiepileptic and chemotherapeutic drugs or epidermal growth factor receptor (EGFR) inhibitor is necessary in many cases."	1.34	Significant drug interaction: phenytoin toxicity due to erlotinib. ( Gabizon, A; Gipps, M; Grenader, T; Shavit, L, 2007)
"Therapeutic measures included seizure prophylaxis with phenytoin and total brain radiation therapy of brain metastases from bronchial carcinoma."	1.33	EMPACT syndrome. ( Loewe, R; Pickl, WF; Stingl, G; Wagner, SN; Wöhrl, S, 2005)
" The pooled data were analyzed using population pharmacokinetic (POP-PK) methods."	1.33	Population pharmacokinetics of motexafin gadolinium in adults with brain metastases or glioblastoma multiforme. ( Boswell, GW; Ford, JM; Hutcheson, SJ; Miles, DR; Phan, SC; Renschler, MF; Smith, JA, 2005)
"Oxazepam was stopped and a second series of dexamethasone pulse therapy was given."	1.31	Successful dexamethasone pulse therapy in a toxic epidermal necrolysis (TEN) patient featuring recurrent TEN to oxazepam. ( Beerthuizen, G; de Jong, MC; Jonkman, MF; Kardaun, SH; Nieuwenhuis, P; Schuttelaar, ML; Toth, GG; van der Meer, JB, 2001)
" Further detailed pharmacokinetic studies of irinotecan in patients receiving concomitant therapy with enzyme-inducing anticonvulsants are required so that rational dosing recommendations can be provided for this patient population."	1.31	Influence of phenytoin on the disposition of irinotecan: a case report. ( Berg, S; Bernstein, M; Blaney, SM; Cherrick, I; Kuttesch, N; Murry, DJ; Salama, V, 2002)
"A 35-year-old man presented with partial seizures 10 years after resection of a left-sided glioblastoma multiforme."	1.30	Transient MRI enhancement in a patient with seizures and previously resected glioma: use of MRS. ( Cecil, KM; Hackney, DB; Lenkinski, RE; Pruitt, AA; Quan, D, 1999)
"Carbamazepine was given to 15 patients, phenytoin to 12, and barbiturate to 7, respectively; 42 patients also received corticosteroids."	1.30	Late radiation toxicity after whole brain radiotherapy: the influence of antiepileptic drugs. ( Leicht, A; Motaref, B; Nestle, U; Nieder, C; Niewald, M; Schnabel, K, 1999)
"004), the elimination half-life was 35% shorter (12."	1.30	Cytochrome P450-inducing antiepileptics increase the clearance of vincristine in patients with brain tumors. ( Joensuu, H; Kivistö, KT; Mäenpää, H; Neuvonen, PJ; Villikka, K, 1999)
" In addition, there was a significant dose-response association between the development of procarbazine hypersensitivity and the presence of therapeutic anticonvulsant serum levels (p = 0."	1.30	Anticonvulsant usage is associated with an increased risk of procarbazine hypersensitivity reactions in patients with brain tumors. ( Coyle, TE; Hurteau, TE; Lehmann, DF; Newman, N, 1997)
"Cerebral cavernous angioma (cavernoma) has previously been treated by resection for all presentations when surgically resectable."	1.28	Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases. ( Churchyard, A; Grainger, K; Khangure, M, 1992)
"The excess numbers of brain cancer were concentrated within 10 years of hospitalization (RR = 20."	1.28	Cancer among epileptic patients exposed to anticonvulsant drugs. ( Boice, JD; Fraumeni, JF; Jensen, JP; Olsen, JH, 1989)
" Apparent volume of distribution was similar in the two groups, but the group treated with phenytoin had an almost statistically significantly shorter dexamethasone mean terminal half-life, an approximately trebled mean plasma clearance, and a mean oral bioavailability of the steroid of only 33%, compared with a mean 84% oral bioavailability in those not receiving phenytoin."	1.27	Phenytoin impairs the bioavailability of dexamethasone in neurological and neurosurgical patients. ( Brophy, T; Chalk, JB; Eadie, MJ; Ridgeway, K; Yelland, JD, 1984)
"During this period, partial seizures occurred."	1.27	Decreased phenytoin level during antineoplastic therapy: a case report. ( Albani, F; Baruzzi, A; Bollini, C; Bollini, P; Cacciari, L; Ida, N; Riva, R, 1983)
" Very rarely, the toxic neurological manifestations of this drug are of cerebral origin."	1.26	Transient hemiparesis: a rare manifestation of diphenylhydantoin toxicity. Report of two cases. ( Findler, G; Lavy, S, 1979)
"Pretreatment with phenytoin, sodium methylprednisolone succinate and dexamethasone had little or no effect."	1.26	The effect of phenobarbital pretreatment on the antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl-1-nitrosourea (PCNU), and on the plasma p ( Byrd, A; Finn, A; Levin, VA; Stearns, J; Weinkam, RJ, 1979)
"Patients without a history of seizures preoperatively had a similar incidence of seizures postoperatively, whether anticonvulsant medications were prescribed prophylactically or not."	1.26	The role of anticonvulsant medications in the management of patients with anaplastic gliomas. ( Dudka, L; Mahaley, MS, 1981)
" In patients with predisposing factors to postoperative seizures, anticonvulsant drugs should be administered before or immediately following craniotomy in adequate dosage to rapidly achieve and maintain effective plasma levels."	1.26	Seizures following intracranial surgery: incidence in the first post-operative week. ( Matthew, E; Odusote, K; Sherwin, AL; Stratford, JG; Welner, SA, 1980)
"dog was presented because of a convulsion."	1.25	Astrocytoma in a dog causing convulsions. ( Berryman, FC; de Lahunta, A, 1975)

Research

Studies (154)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Effects of Hepatic Enzyme Inducing Drugs Such as Anticonvulsants, on the PK of Celecoxib

Timeframe	Studies, this research(%)	All Research%
pre-1990	51 (33.12)	18.7374
1990's	35 (22.73)	18.2507
2000's	38 (24.68)	29.6817
2010's	27 (17.53)	24.3611
2020's	3 (1.95)	2.80

Authors	Studies
Youngerman, BE	1
Joiner, EF	1
Wang, X	2
Yang, J	1
Welch, MR	1
McKhann, GM	1
Wright, JD	1
Hershman, DL	1
Neugut, AI	1
Bruce, JN	1
Al Ghamdi, RM	1
Turkistani, AN	1
Ben Ali, H	1
Otani, R	1
Yamada, R	1
Kawaguchi, K	1
Kikuchi, M	1
Kushihara, Y	1
Shinoura, N	1
Khandelwal, A	1
Sokhal, N	1
Kumar, N	1
Singh, S	1
Sokhal, S	1
Narasimha, VL	1
Basavaraju, R	1
Mangalore, S	1
Mehta, UM	1
Laghari, AA	1
Ahmed, SI	1
Qadeer, N	1
Shamim, MS	1
Wychowski, T	1
Wang, H	1
Buniak, L	1
Henry, JC	1
Mohile, N	1
Tanaka, H	1
Jotoku, H	1
Takasaki, M	1
Ibayashi, Y	1
Watanabe, K	1
Takahashi, M	1
Bishop, AJ	1
Chang, M	1
Lacouture, ME	1
Barker, CA	1
Iuchi, T	2
Hasegawa, Y	2
Kawasaki, K	2
Sakaida, T	2
Ahmed, I	2
Biswas, A	2
Krishnamurthy, S	1
Julka, PK	1
Kuwabara, K	1
Matsumoto, M	1
Taguchi, Y	1
Takashima, S	1
Tanaka, K	1
Berg, AK	1
Buckner, JC	1
Galanis, E	1
Jaeckle, KA	1
Ames, MM	1
Reid, JM	1
Sonis, J	1
Borczuk, P	1
Ptak, T	1
Miller, ES	1
Ohgami, M	1
Kaburagi, T	1
Kurosawa, A	1
Homma, M	1
Lim, DA	1
Tarapore, P	1
Chang, E	1
Burt, M	1
Chakalian, L	1
Barbaro, N	1
Chang, S	1
Lamborn, KR	1
McDermott, MW	1
Strohkirch, J	1
Platts-Mills, T	1
Sogawa, Y	1
Kan, L	1
Levy, AS	1
Maytal, J	1
Shinnar, S	1
Crespo Pérez, L	1
Moreira Vicente, V	1
Cano Ruiz, A	1
Gobernado Serrano, JM	1
Cobo Ibañez, N	1
Milicua Salamero, JM	1
Goyal, S	1
Puri, T	1
Mohanti, BK	1
Kandil, AO	1
Dvorak, T	1
Mignano, J	1
Wu, JK	1
Zhu, JJ	1
Miranda, M	1
Kuester, G	1
Ríos, L	1
Basaez, E	1
Hazard, S	1
Aydoğan, K	1
Vatansever, S	1
Adim, SB	1
Saricaoglu, H	1
Fidan, E	1
Fidan, M	1
Ozdemir, F	1
Kavgaci, H	1
Aydin, F	2
Bilgili, SG	1
Calka, O	1
Karadag, AS	1
Burakgazi, AZ	1
Kerrigan, S	1
Grant, R	1
Swisher, CB	1
Doreswamy, M	1
Gingrich, KJ	1
Vredenburgh, JJ	1
Kolls, BJ	1
Kern, K	1
Schebesch, KM	1
Schlaier, J	1
Hansen, E	1
Feigl, GC	1
Brawanski, AT	1
Lange, M	1
Wallace, EM	1
O'Reilly, M	1
Twomey, M	1
Weller, M	1
Stupp, R	1
Wick, W	1
Guthrie, GD	1
Eljamel, S	1
Wu, AS	1
Trinh, VT	1
Suki, D	1
Graham, S	1
Forman, A	1
Weinberg, JS	1
McCutcheon, IE	2
Prabhu, SS	1
Heimberger, AB	1
Sawaya, R	1
Qiao, W	1
Hess, K	1
Lang, FF	1
Kuhn, JG	1
Cutts, J	1
Lee, G	1
Berarducci, M	1
Thomas, C	1
Dempsey, PK	1
Kadish, SP	1
Rüegg, S	1
Camartin, C	1
Reinhart, WH	1
Kuhn, M	1
Citerio, G	1
Nobili, A	1
Airoldi, L	1
Pastorelli, R	1
Patruno, A	1
Forsyth, PA	1
Weaver, S	1
Fulton, D	1
Brasher, PM	1
Sutherland, G	1
Stewart, D	1
Hagen, NA	1
Barnes, P	1
Cairncross, JG	1
DeAngelis, LM	1
Paueksakon, P	1
Shaya, M	1
Harper, R	1
Hicks, J	1
Truong, L	1
Goodman, JC	1
Powell, SZ	1
ATKINSON, M	1
ROSENBLUM, I	1
STEIN, AA	1
JANZ, D	1
KAUTZ, G	1
MARX, GF	1
SCHEINBERG, L	1
ROMNEY, SL	1
Reichenberg, J	1
Lucas, A	1
Shehan, JM	1
Cooper, JR	1
Aguiar, D	1
Pazo, R	1
Durán, I	1
Terrasa, J	1
Arrivi, A	1
Manzano, H	1
Martín, J	1
Rifá, J	1
Oner Dincbas, F	1
Yörük, S	1
Demirkesen, C	1
Uzel, O	1
Koca, S	1
Sirven, JI	1
Wingerchuk, DM	1
Drazkowski, JF	1
Lyons, MK	1
Zimmerman, RS	1
Lian, J	1
Dundas, G	1
Tron, V	1
Lauzon, G	1
Roa, W	1
Miles, DR	1
Smith, JA	1
Phan, SC	1
Hutcheson, SJ	1
Renschler, MF	1
Ford, JM	1
Boswell, GW	1
Puri, V	1
Chaudhry, N	1
Gulati, P	1
Tatke, M	1
Singh, D	1
Lee, KC	1
Garcia, PA	1
Alldredge, BK	1
Wöhrl, S	1
Loewe, R	1
Pickl, WF	1
Stingl, G	1
Wagner, SN	1
Cokluk, C	1
Senturk, N	1
Aydin, K	1
Canturk, MT	1
Turanli, AY	1
García Sánchez, I	1
Chavarria Mur, E	1
Avilés Izquierdo, J	1
Molina Sánchez-Cabezudo, F	1
Vera López, E	1
Gilsanz Fernández, C	1
Jenkins, A	1
Grenader, T	1
Gipps, M	1
Shavit, L	1
Gabizon, A	1
Ashamalla, H	1
Zaki, B	1
Mokhtar, B	1
Lewis, L	1
Lavaf, A	1
Nasr, H	1
Colella, F	1
Dosik, D	1
Krishnamurthy, M	1
Saad, N	1
Guriguis, A	1
Forsby, A	1
Blaauboer, B	1
Fernández, FA	1
Pintor, E	1
Quesada, R	1
Garcés, FJ	1
Grossman, SA	2
Olson, J	1
Batchelor, T	1
Peereboom, D	1
Lesser, G	1
Desideri, S	1
Ye, X	1
Hammour, T	1
Supko, JG	1
Aladdin, Y	1
Gross, DW	1
Barbosa, LA	1
Teixeira, CR	1
Walker, MD	1
Strike, TA	1
Sayk, J	1
Kmietzyk, HJ	1
Nelson, DF	1
Gillespie, BW	1
Diener, MD	1
Davis, DR	1
Wasserman, T	1
Phillips, TL	1
Stetz, J	1
Vizi, ES	1
Pásztor, E	1
Allen, RW	1
Jung, AL	1
Chalk, JB	1
Ridgeway, K	1
Brophy, T	1
Yelland, JD	1
Eadie, MJ	1
Karbowski, K	1
Scherber, A	1
Richter, K	1
Bollini, P	1
Riva, R	1
Albani, F	1
Ida, N	1
Cacciari, L	1
Bollini, C	1
Baruzzi, A	1
Bleehen, NM	2
Matthew, E	1
Sherwin, AL	1
Welner, SA	1
Odusote, K	1
Stratford, JG	1
Bamberg, M	1
Tamulevicius, P	1
Streffer, C	1
Scherer, E	1
Dunn, JH	1
Reynolds, AF	1
Mahaley, MS	1
Dudka, L	1
Workman, P	1
Wiltshire, CR	1
Rabinowicz, AL	2
Hinton, DR	1
Dyck, P	1
Couldwell, WT	1
Borg, MF	1
Probert, JC	1
Zwi, LJ	1
Landolt, H	1
Langemann, H	1
Probst, A	1
Gratzl, O	1
Janinis, J	1
Panagos, G	1
Panousaki, A	1
Skarlos, D	1
Athanasiou, E	1
Karpasitis, N	1
Pirounaki, M	1
Cockey, GH	1
Amann, ST	1
Reents, SB	1
Lynch, JW	1
Gattis, WA	1
May, DB	1
Frangogiannis, NG	1
Boridy, I	1
Mazhar, M	1
Mathews, R	1
Gangopadhyay, S	1
Cate, T	1
Lukovits, TG	1
Fadul, CE	1
Pipas, JM	1
Williamson, PD	1
Fuller, GN	1
Kaba, SE	1
Ginsberg, LE	1
Langford, LA	1
Koukkari, MW	1
Vanefsky, MA	1
Steinberg, GK	1
Hahn, JS	1
Lehmann, DF	1
Hurteau, TE	1
Newman, N	1
Coyle, TE	1
Salvat, JM	1
Leiguarda, RC	1
Demonty, F	1
Salvat, F	1
Cervio, A	1
Manes, F	1
Lazarowski, A	1
Mishriki, YY	1
Acostamadiedo, JM	1
Perniciaro, C	1
Rogers, RS	1
Nobile, M	1
Lagostena, L	1
Choy, M	1
Winter, ME	1
Arroyo, S	1
Rumiá, J	1
Martínez, I	1
Ribalta, T	1
Micali, G	1
Linthicum, K	1
Han, N	1
West, DP	1
Mamon, HJ	1
Wen, PY	1
Burns, AC	1
Loeffler, JS	1
Awada, A	1
Amene, P	1
al Jumah, M	1
al Beladi, K	1
Quan, D	1
Hackney, DB	1
Pruitt, AA	1
Lenkinski, RE	1
Cecil, KM	1
Goh, KY	1
Conway, EJ	1
DaRosso, RC	1
Muszynski, CA	1
Epstein, FJ	1
Nieder, C	1
Leicht, A	1
Motaref, B	1
Nestle, U	1
Niewald, M	1
Schnabel, K	1
Villikka, K	1
Kivistö, KT	1
Mäenpää, H	1
Joensuu, H	1
Neuvonen, PJ	1
Tucha, O	1
Smely, C	1
Preier, M	1
Lange, KW	1
Yamada, M	1
Ohkawa, M	1
Tamura, K	1
Mabuchi, E	1
Kishima, H	1
Tamura, M	1
Shimizu, K	1
Dillman, RO	1
Shea, WM	1
Tai, DF	1
Mahdavi, K	1
Barth, NM	1
Kharkar, BR	1
Poor, MM	1
Church, CK	1
DePriest, C	1
Tobias, JD	1
Johnson, JO	1
Eralp, Y	1
Aydiner, A	1
Taş, F	1
Saip, P	1
Topuz, E	1
van der Meer, JB	1
Schuttelaar, ML	1
Toth, GG	1
Kardaun, SH	1
Beerthuizen, G	1
de Jong, MC	1
Jonkman, MF	1
Nieuwenhuis, P	1
Mathijssen, RH	1
Sparreboom, A	1
Dumez, H	1
van Oosterom, AT	1
de Bruijn, EA	1
Konishi, H	1
Morita, K	1
Minouchi, T	1
Nakajima, M	1
Matsuda, M	1
Yamaji, A	1
Murry, DJ	1
Cherrick, I	1
Salama, V	1
Berg, S	1
Bernstein, M	1
Kuttesch, N	1
Blaney, SM	1
Vincent, FM	1
White, SJ	1
McLean, AE	1
Howland, C	1
Glötzner, FL	2
Tilbury, RS	1
Findler, G	1
Lavy, S	1
Kornblith, PL	1
Hartnett, LC	1
Anderson, LP	1
Quindlen, EA	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Prospective Trial for Validation of the Role of Levetiracetam as a Sensitizer of Temozolomide in the Treatment of Newly Diagnosed Glioblastoma Patients[NCT02815410]	Phase 2	73 participants (Anticipated)	Interventional	2016-07-31	Not yet recruiting
A Pharmacokinetic Study of the Interaction Between Celecoxib and Anticonvulsant Drugs in Patients With Newly Diagnosed Glioblastoma Multiforme Undergoing Radiation Therapy[NCT00068770]	Phase 2	35 participants (Actual)	Interventional	2003-10-31	Terminated (stopped due to EORTC trail showed TMZ & RT conferred significant survivial in this population)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

subjects will take one dose of celecoxib and will then have 6 hours of blood draws, day 2 subject will take 2 doses of celecoxib 8 hours apart with 2 additional blood samples, one hour apart. Subject, will continue to take 2 doses of celecoxib for 6 weeks, with a sample (PK) drawn every week prior to the first dose of the week. Comparison of Cmax of Celecoxib is reported (NCT00068770)
Timeframe: First dose of celecoxib through completion of radiation, 6 weeks.

Overall Survival

Intervention	(ng/ml) (Geometric Mean)
nonp450	1752
p450	1813

duration of survival when celecoxib is administered concurrently with radiation in pts with newly diagnosed glioblastoma multiforme (NCT00068770)
Timeframe: date pt started treatment to date pt last known alive

Intervention	months (Mean)
p450 ( +EIASD)	11.5
nonp450 (-EIASD)	16

Article	Year
Choice of therapeutic anti-seizure medication in patients with brain tumour. JPMA. The Journal of the Pakistan Medical Association, 2019, Volume: 69, Issue:3 Topics: Anticonvulsants; Brain Neoplasms; Drug Therapy, Combination; Epilepsy; Gabapentin; Glioma; Humans; L	2019
[A case of phenytoin intoxication caused by interaction between phenytoin and capecitabine]. Brain and nerve = Shinkei kenkyu no shinpo, 2015, Volume: 67, Issue:2 Topics: Adult; Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Capecitabine; Deoxycytidine; Drug In	2015
[Anticonvulsant hypersensitivity syndrome: an entity to be remembered]. Gastroenterologia y hepatologia, 2009, Volume: 32, Issue:10 Topics: Adolescent; Amines; Anemia, Hemolytic; Anticonvulsants; Astrocytoma; Brain Neoplasms; Carbamazepine;	2009
Empact syndrome: a case report and review of the literature. International journal of dermatology, 2010, Volume: 49, Issue:8 Topics: Anticonvulsants; Brain Neoplasms; Drug Eruptions; Epilepsy; Humans; Lung Neoplasms; Male; Middle Age	2010
Antiepileptic drugs for treating seizures in adults with brain tumours. The Cochrane database of systematic reviews, 2011, Aug-10, Issue:8 Topics: Adult; Anticonvulsants; Brain Neoplasms; Drug Substitution; Humans; Levetiracetam; Phenytoin; Pirace	2011
Epilepsy meets cancer: when, why, and what to do about it? The Lancet. Oncology, 2012, Volume: 13, Issue:9 Topics: Animals; Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Causality; Comorbidity; Drug Inter	2012
Impact of particular antiepileptic drugs on the survival of patients with glioblastoma multiforme. Journal of neurosurgery, 2013, Volume: 118, Issue:4 Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain Neoplasms; Carbamazepine; Cohort Studies; Female; Gl	2013
Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of the literature. International journal of dermatology, 2004, Volume: 43, Issue:1 Topics: Anticonvulsants; Brain Neoplasms; Drug Eruptions; Erythema Multiforme; Humans; Male; Middle Aged; Ph	2004
Brain tumors in hereditary multiple system hamartomatosis (tuberous sclerosis). Journal of neurosurgery, 1971, Volume: 34, Issue:2 Pt 1 Topics: Anticonvulsants; Astrocytoma; Brain Neoplasms; Cerebral Ventricles; Child; Diagnosis, Differential;	1971
Seizure prophylaxis in patients with brain tumors: a meta-analysis. Mayo Clinic proceedings, 2004, Volume: 79, Issue:12 Topics: Anticonvulsants; Brain Neoplasms; Comorbidity; Confidence Intervals; Dose-Response Relationship, Dru	2004
[The post-traumatic epilepsy (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1981, Sep-01, Volume: 70, Issue:36 Topics: Brain Concussion; Brain Injuries; Brain Neoplasms; Carbamazepine; Diagnostic Errors; Electroencephal	1981
Is phenytoin contraindicated in patients receiving cranial irradiation? Australasian radiology, 1995, Volume: 39, Issue:1 Topics: Biopsy; Bone Neoplasms; Brain Neoplasms; Breast Neoplasms; Carcinoma; Combined Modality Therapy; Con	1995
Possible interaction involving phenytoin, dexamethasone, and antineoplastic agents: a case report and review. The Annals of pharmacotherapy, 1996, Volume: 30, Issue:5 Topics: Adult; Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Dexamethasone; Drug Interactions; Hu	1996
Phenytoin-induced linear IgA bullous disease. Journal of the American Academy of Dermatology, 1998, Volume: 38, Issue:2 Pt 2 Topics: Aged; Anticonvulsants; Astrocytoma; Autoimmune Diseases; Biopsy; Brain Neoplasms; Combined Modality	1998
Increased risk of erythema multiforme major with combination anticonvulsant and radiation therapies. Pharmacotherapy, 1999, Volume: 19, Issue:2 Topics: Adult; Aged; Anticonvulsants; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Femal	1999
Sympathetic storms in a child with a midbrain glioma: a variant of diencephalic seizures. Pediatric neurology, 1999, Volume: 21, Issue:4 Topics: Anticonvulsants; Astrocytoma; Autonomic Nervous System Diseases; Brain Neoplasms; Child; Clonidine;	1999
Decreased phenytoin levels in patients receiving chemotherapy. The American journal of medicine, 1989, Volume: 87, Issue:5 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cisplatin;	1989
Epilepsy. Progress in neurology and psychiatry, 1967, Volume: 22 Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Amphetamine; Anesthetics, Local; Anticonvulsants; Ba	1967
Recent progress in epilepsy. Diagnostic procedures and treatment. California medicine, 1973, Volume: 119, Issue:1 Topics: Anticonvulsants; Brain Neoplasms; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Temporal Lob	1973

Article	Year
Levetiracetam versus phenytoin for seizure prophylaxis during and early after craniotomy for brain tumours: a phase II prospective, randomised study. Journal of neurology, neurosurgery, and psychiatry, 2015, Volume: 86, Issue:10 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Neoplasms; Cohort Studies; Cranio	2015
Quantification of the impact of enzyme-inducing antiepileptic drugs on irinotecan pharmacokinetics and SN-38 exposure. Journal of clinical pharmacology, 2015, Volume: 55, Issue:11 Topics: Adult; Aged; Anticonvulsants; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Carb	2015
Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. Journal of neuro-oncology, 2009, Volume: 93, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Neoplasms; Craniotomy; Female; Glioma; Humans	2009
A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors. Journal of neurosurgery, 2013, Volume: 118, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Bayes Theorem; Brain Neoplasms; Craniot	2013
Influence of anticonvulsants on the metabolism and elimination of irinotecan. A North American Brain Tumor Consortium preliminary report. Oncology (Williston Park, N.Y.), 2002, Volume: 16, Issue:8 Suppl 7 Topics: Anticonvulsants; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Carbamazepine; Do	2002
Prophylactic anticonvulsants in patients with brain tumour. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2003, Volume: 30, Issue:2 Topics: Anticonvulsants; Brain Neoplasms; Disease Progression; Female; Humans; Incidence; Male; Middle Aged;	2003
Fractionated stereotactic radiotherapy boost and weekly paclitaxel in malignant gliomas clinical and pharmacokinetics results. Technology in cancer research & treatment, 2007, Volume: 6, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Antineoplastic Agents, Phytogenic; Brain Neoplasms;	2007
Effect of phenytoin on celecoxib pharmacokinetics in patients with glioblastoma. Neuro-oncology, 2008, Volume: 10, Issue:2 Topics: Aged; Aged, 80 and over; Anticonvulsants; Antineoplastic Agents; Area Under Curve; Brain Neoplasms;	2008
Is misonidazole neurotoxicity altered by the use of phenytoin and/or dexamethasone in RTOG 79-18 and RTOG 79-16? International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Brain Neoplasms; Clinical Trials as Topic; Dexamethasone; Female; Glioma; Humans; Male; Middle Aged;	1984
The Cambridge glioma trial of misonidazole and radiation therapy with associated pharmacokinetic studies. Cancer clinical trials, 1980,Fall, Volume: 3, Issue:3 Topics: Brain Neoplasms; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Glioma; Head an	1980
Use of antiepileptic drugs in nontraumatic neurosurgical procedures. Is there any best route and time of administration? Clinical neuropharmacology, 1997, Volume: 20, Issue:5 Topics: Administration, Oral; Adult; Aged; Aneurysm; Anticonvulsants; Arteriovenous Malformations; Brain Neo	1997
Interferon-alpha2a and 13-cis-retinoic acid with radiation treatment for high-grade glioma. Neuro-oncology, 2001, Volume: 3, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Adjuvant; Comb	2001
Fluctuation of serum phenytoin concentrations during autologous bone marrow transplant for primary central nervous system tumors. Journal of neuro-oncology, 1992, Volume: 12, Issue:1 Topics: Adult; Anticonvulsants; Astrocytoma; Bone Marrow Transplantation; Brain Neoplasms; Carbamazepine; Fe	1992
Post-operative epilepsy and the efficacy of anticonvulsant therapy. Acta neurochirurgica. Supplementum, 1990, Volume: 50 Topics: Anticonvulsants; Brain Neoplasms; Carbamazepine; Epilepsies, Partial; Follow-Up Studies; Glioma; Hum	1990

Article	Year
Patterns of seizure prophylaxis after oncologic neurosurgery. Journal of neuro-oncology, 2020, Volume: 146, Issue:1 Topics: Adolescent; Adult; Anticonvulsants; Brain Neoplasms; Craniotomy; Female; Follow-Up Studies; Humans;	2020
Phenytoin Seizure Prophylaxis Therapy Resulting in Severe Thrombocytopenia After Brain Tumor Debulking Surgery. The American journal of case reports, 2020, Jan-30, Volume: 21 Topics: Adult; Anticonvulsants; Brain Neoplasms; Cytoreduction Surgical Procedures; Humans; Immunoglobulins,	2020
Utility of monitoring the serum levetiracetam concentration for intraoperative seizure control during awake craniotomy. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2021, Volume: 89 Topics: Adult; Anticonvulsants; Brain Neoplasms; Craniotomy; Humans; Levetiracetam; Middle Aged; Phenytoin;	2021
Phenytoin-induced Excessive Sedation During Awake Craniotomy: An Unusual Observation. Journal of neurosurgical anesthesiology, 2019, Volume: 31, Issue:1 Topics: Adult; Brain Neoplasms; Conscious Sedation; Consciousness Monitors; Craniotomy; Glioma; Humans; Male	2019
Precuneus and psychiatric manifestations: Novel neurobiological formulations through lesion based connectivity mapping of psychopathology. Asian journal of psychiatry, 2019, Volume: 39 Topics: Anticonvulsants; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Brain Mapping; Brai	2019
Considerations in prophylaxis for tumor-associated epilepsy: prevention of status epilepticus and tolerability of newer generation AEDs. Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:11 Topics: Aged; Aged, 80 and over; Anticonvulsants; Brain Neoplasms; Female; Humans; Levetiracetam; Male; Midd	2013
[Effect of capecitabine therapy on the blood levels of antiepileptic drugs - report of two cases]. Gan to kagaku ryoho. Cancer & chemotherapy, 2014, Volume: 41, Issue:4 Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Brain Neoplasms; Breast Neoplasms; Capecitabine; D	2014
EMPACT syndrome: limited evidence despite a high-risk cohort. Journal of neuro-oncology, 2014, Volume: 119, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Neoplasms; Child; Cranial Irradia	2014
Epilepsy in patients with gliomas: incidence and control of seizures. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2015, Volume: 22, Issue:1 Topics: Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Carbamazepine; Female; Glioma; Humans; Inci	2015
Toxic epidermal necrolysis in a patient receiving concurrent phenytoin and whole brain and thoracic radiotherapy. Saudi medical journal, 2014, Volume: 35, Issue:11 Topics: Anticonvulsants; Brain Neoplasms; Carcinoma, Squamous Cell; Humans; Lung Neoplasms; Male; Middle Age	2014
Seizure and Fever. The Journal of emergency medicine, 2016, Volume: 50, Issue:5 Topics: Acyclovir; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antiviral Agents; Brain Neoplasms; Ceftri	2016
Drug interaction between erlotinib and phenytoin for brain metastases in a patient with nonsmall cell lung cancer. Lung cancer (Amsterdam, Netherlands), 2016, Volume: 101 Topics: Brain; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cytochrome P-450 CYP1A2 Inducers; Cytochrome	2016
Video recording devices as a diagnostic aid. The Journal of emergency medicine, 2011, Volume: 40, Issue:4 Topics: Adult; Anticonvulsants; Brain Neoplasms; Hemangioma, Cavernous, Central Nervous System; Humans; Magn	2011
The use of antiepileptic drugs in pediatric brain tumor patients. Pediatric neurology, 2009, Volume: 41, Issue:3 Topics: Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Carbamazepine; Child; Drug Interactions; Fo	2009
Stevens-Johnson syndrome following concurrent phenytoin and holocranial radiotherapy. Acta oncologica (Stockholm, Sweden), 2010, Volume: 49, Issue:2 Topics: Anti-Inflammatory Agents; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Brain Neo	2010
Multifocal Stevens-Johnson syndrome after concurrent phenytoin and cranial and thoracic radiation treatment, a case report. Radiation oncology (London, England), 2010, Jun-04, Volume: 5 Topics: Anticonvulsants; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Humans; Male; Midd	2010
Refractory nonconvulsive status epilepticus responsive to music as an add-on therapy: a second case. Epilepsy & behavior : E&B, 2010, Volume: 19, Issue:3 Topics: Aged; Anticonvulsants; Brain Neoplasms; Humans; Lung Neoplasms; Male; Music Therapy; Phenytoin; Stat	2010
Phenytoin- and cranial radiotherapy-induced toxic epidermal necrolysis treated with combination therapy: systemic steroid and intravenous immunoglobulin. Medical oncology (Northwood, London, England), 2012, Volume: 29, Issue:2 Topics: Adenocarcinoma; Anti-Inflammatory Agents; Anticonvulsants; Brain Neoplasms; Combined Modality Therap	2012
EMPACT syndrome. Cutaneous and ocular toxicology, 2011, Volume: 30, Issue:4 Topics: Adult; Anticonvulsants; Brain Neoplasms; Cranial Irradiation; Erythema Multiforme; Fatal Outcome; Fe	2011
Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors. Neurocritical care, 2012, Volume: 16, Issue:1 Topics: Acute Disease; Aged; Anticonvulsants; Brain Neoplasms; Drug Therapy, Combination; Female; gamma-Amin	2012
Levetiracetam compared to phenytoin for the prevention of postoperative seizures after craniotomy for intracranial tumours in patients without epilepsy. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2012, Volume: 19, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Neoplasms; Child; Contraindications; Craniotomy; F	2012
A review of the use of antiepileptic drugs in high-grade central nervous system tumors. The American journal of hospice & palliative care, 2012, Volume: 29, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Automobile Driving; Brain Neoplasms; Female; Humans	2012
Goosebumps. Lancet (London, England), 2002, Aug-31, Volume: 360, Issue:9334 Topics: Astrocytoma; Brain Neoplasms; Carmustine; Dexamethasone; Diagnosis, Differential; Frontal Lobe; Huma	2002
Dexamethasone/phenytoin interactions: neurooncological concerns. Swiss medical weekly, 2002, Jul-27, Volume: 132, Issue:29-30 Topics: Anti-Inflammatory Agents; Anticonvulsants; Brain Neoplasms; Dexamethasone; Drug Interactions; Humans	2002
[Brain irradiation and phenytoin: a dangerous liaison?]. Praxis, 2003, Feb-26, Volume: 92, Issue:9 Topics: Adenocarcinoma; Adult; Aged; Anticonvulsants; Brain Neoplasms; Drug Eruptions; Female; Glioblastoma;	2003
Severe intoxication after phenytoin infusion: a preventable pharmacogenetic adverse reaction. Neurology, 2003, Apr-22, Volume: 60, Issue:8 Topics: Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Brain Neoplasms; Chemical and Drug Induced Li	2003
Local cryoglobulin deposition in primary central nervous system lymphoma. Human pathology, 2003, Volume: 34, Issue:7 Topics: Adult; Anticonvulsants; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Brain Neoplasms; Cell Nu	2003
Positional vertigo. Three instructive cases. Archives of otolaryngology (Chicago, Ill. : 1960), 1963, Volume: 77 Topics: Brain Neoplasms; Carcinoma, Bronchogenic; Cerebellar Neoplasms; Cerebral Ventricle Neoplasms; Ependy	1963
PREFERENTIAL DISTRIBUTION OF DIPHENYLHYDANTOIN IN PRIMARY HUMAN BRAIN TUMORS. Biochemical pharmacology, 1963, Volume: 12 Topics: Adenocarcinoma; Animals; Astrocytoma; Brain Neoplasms; Ependymoma; Humans; Mammary Neoplasms, Animal	1963
[ETIOLOGY AND THERAPY OF STATUS EPILEPTICUS]. Deutsche medizinische Wochenschrift (1946), 1963, Nov-08, Volume: 88 Topics: Abortion, Septic; Anticonvulsants; Birth Injuries; Brain Injuries; Brain Neoplasms; Chloral Hydrate;	1963
ANESTHETIC MANAGEMENT OF THE PARTURIENT WITH INTRACRANIAL TUMOR. Obstetrics and gynecology, 1964, Volume: 24 Topics: Anesthesia; Anesthesia, Endotracheal; Anesthesia, Spinal; Anesthetics; Angiography; Brain Neoplasms;	1964
Toxic epidermal necrolysis in patients receiving anticonvulsants and cranial irradiation: a risk to consider. Journal of neuro-oncology, 2004, Volume: 66, Issue:3 Topics: Anticonvulsants; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cranial Irradiation; Humans; Lung	2004
Toxic epidermal necrolysis after cranial radiotherapy and phenytoin treatment. Onkologie, 2004, Volume: 27, Issue:4 Topics: Aged; Anticonvulsants; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; C	2004
radiotherapy-induced ID reaction. American journal of clinical oncology, 2005, Volume: 28, Issue:1 Topics: Anti-Inflammatory Agents; Anticonvulsants; Brain Neoplasms; Dexamethasone; Diagnosis, Differential;	2005
Population pharmacokinetics of motexafin gadolinium in adults with brain metastases or glioblastoma multiforme. Journal of clinical pharmacology, 2005, Volume: 45, Issue:3 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alkaline Phosphatase; Anticonvulsants; Antineoplastic A	2005
Recurrent tumefactive demyelination in a child. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2005, Volume: 12, Issue:4 Topics: Adolescent; Anticonvulsants; Astrocytes; Brain Neoplasms; Corpus Callosum; Demyelinating Diseases; D	2005
Clinical features of status epilepticus in patients with HIV infection. Neurology, 2005, Jul-26, Volume: 65, Issue:2 Topics: Adult; Anti-Retroviral Agents; Anticonvulsants; Benzodiazepines; Brain Neoplasms; Central Nervous Sy	2005
EMPACT syndrome. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2005, Volume: 3, Issue:1 Topics: Adrenal Cortex Hormones; Anticonvulsants; Brain Neoplasms; Bronchial Neoplasms; Drug Eruptions; Eryt	2005
Stevens-Johnson syndrome in two patients treated with cranial irradiation and phenytoin. Journal of the European Academy of Dermatology and Venereology : JEADV, 2006, Volume: 20, Issue:5 Topics: Anticonvulsants; Brain Neoplasms; Cranial Irradiation; Humans; Male; Middle Aged; Phenytoin; Stevens	2006
[Odinophagia and cutaneous lesions in patient with cerebral metastases]. Revista clinica espanola, 2006, Volume: 206, Issue:5 Topics: Aged; Anticonvulsants; Back; Brain Neoplasms; Cyclosporine; Dermis; Epilepsy; Fatal Outcome; Humans;	2006
A case of phenytoin toxicity in a patient with advanced lung cancer. Palliative medicine, 2006, Volume: 20, Issue:4 Topics: Anticonvulsants; Brain Neoplasms; Confusion; Fatal Outcome; Humans; Lung Neoplasms; Male; Middle Age	2006
Significant drug interaction: phenytoin toxicity due to erlotinib. Lung cancer (Amsterdam, Netherlands), 2007, Volume: 57, Issue:3 Topics: Anticonvulsants; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Drug Interactions; Erlotinib Hydro	2007
Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity. Human & experimental toxicology, 2007, Volume: 26, Issue:4 Topics: Acrylamide; Animals; Anticonvulsants; Brain Neoplasms; Caffeine; Calcium Channels; Central Nervous S	2007
[Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy]. Actas dermo-sifiliograficas, 2007, Volume: 98, Issue:7 Topics: Adenocarcinoma; Aged; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Combined Modality Therapy;	2007
Refractory status epilepticus during pregnancy secondary to cavernous angioma. Epilepsia, 2008, Volume: 49, Issue:9 Topics: Abortion, Induced; Abortion, Therapeutic; Anticonvulsants; Brain Neoplasms; Female; Hemangioma, Cave	2008
Erythema multiforme associated with prophylactic use of phenytoin during cranial radiation therapy. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2008, Jun-01, Volume: 65, Issue:11 Topics: Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cranial	2008
Misonidazole peripheral neuropathy: its relationship to plasma concentration and other drugs. Cancer clinical trials, 1980,Summer, Volume: 3, Issue:2 Topics: Adrenal Cortex Hormones; Barbiturates; Brain Neoplasms; Drug Interactions; Female; Glioma; Half-Life	1980
[Survival period of patients with gliomata or glioblastomata under anti-convulsive therapy (author's transl)]. Der Nervenarzt, 1981, Volume: 52, Issue:10 Topics: Adult; Brain Neoplasms; Epilepsy; Female; Glioblastoma; Glioma; Humans; Male; Phenytoin; Prognosis	1981
Release of acetylcholine from isolated human cortical slices: inhibitory effect of norepinephrine and phenytoin. Experimental neurology, 1981, Volume: 73, Issue:1 Topics: Acetylcholine; Adenosine Triphosphatases; Brain Neoplasms; Cell Membrane; Cerebral Cortex; Humans; I	1981
Fetal hydantoin syndrome and malignancy. The Journal of pediatrics, 1984, Volume: 105, Issue:4 Topics: Brain Neoplasms; Female; Fetal Alcohol Spectrum Disorders; Humans; Hydantoins; Infant, Newborn; Neur	1984
Phenytoin impairs the bioavailability of dexamethasone in neurological and neurosurgical patients. Journal of neurology, neurosurgery, and psychiatry, 1984, Volume: 47, Issue:10 Topics: Adult; Aged; Biological Availability; Brain Diseases; Brain Neoplasms; Dexamethasone; Drug Interacti	1984
[The distribution of drugs between plasma, brain and cerebrospinal fluid in the human]. Sammlung zwangloser Abhandlungen aus dem Gebiete der Psychiatrie und Neurologie, 1982, Volume: 50 Topics: Blood-Brain Barrier; Brain; Brain Neoplasms; Carbamazepine; Diazepam; Humans; Lithium; Nordazepam; P	1982
Decreased phenytoin level during antineoplastic therapy: a case report. Epilepsia, 1983, Volume: 24, Issue:1 Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Drug Interactions; Drug Therapy, Combination; Hu	1983
Seizures following intracranial surgery: incidence in the first post-operative week. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1980, Volume: 7, Issue:4 Topics: Adult; Brain Neoplasms; Cerebrovascular Disorders; Craniotomy; Female; Humans; Male; Middle Aged; Ph	1980
[Clinical experiences with the radiosensitizer Misonidazol (author's transl)]. Strahlentherapie, 1981, Volume: 157, Issue:8 Topics: Adolescent; Adult; Aged; Brain Neoplasms; Dexamethasone; Drug Interactions; Esophageal Neoplasms; Ex	1981
Management of primary brain tumors in adults. Arizona medicine, 1981, Volume: 38, Issue:1 Topics: Adult; Astrocytoma; Brain Neoplasms; Humans; Nitrosourea Compounds; Phenytoin	1981
The role of anticonvulsant medications in the management of patients with anaplastic gliomas. Surgical neurology, 1981, Volume: 16, Issue:6 Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain Neoplasms; Double-Blind Method; Frontal Lobe; Glioma	1981
Phenytoin shortens the half-life of the hypoxic cell radiosensitizer misonidazole in man: implications for possible reduced toxicity. British journal of cancer, 1980, Volume: 41, Issue:2 Topics: Brain Neoplasms; Half-Life; Humans; Kinetics; Misonidazole; Nitroimidazoles; Phenytoin	1980
High-dose tamoxifen in treatment of brain tumors: interaction with antiepileptic drugs. Epilepsia, 1995, Volume: 36, Issue:5 Topics: Adult; Brain Neoplasms; Cell Division; Drug Interactions; Glioma; Humans; Magnetic Resonance Imaging	1995
Levels of water-soluble antioxidants in astrocytoma and in adjacent tumor-free tissue. Journal of neuro-oncology, 1994, Volume: 21, Issue:2 Topics: Adult; Aged; Antioxidants; Artifacts; Ascorbic Acid; Astrocytoma; Biopsy; Brain Chemistry; Brain Ede	1994
Stevens-Johnson syndrome and epidermal necrolysis after administration of sodium phenytoin with cranial irradiation. European journal of cancer (Oxford, England : 1990), 1993, Volume: 29A, Issue:3 Topics: Adult; Brain Neoplasms; Cranial Irradiation; Glioblastoma; Humans; Male; Middle Aged; Phenytoin; Ste	1993
Stevens-Johnson syndrome resulting from whole-brain radiation and phenytoin. American journal of clinical oncology, 1996, Volume: 19, Issue:1 Topics: Anticonvulsants; Brain Neoplasms; Carcinoma, Squamous Cell; Chemoprevention; Cranial Irradiation; De	1996
Cyclophosphamide in the treatment of toxic epidermal necrolysis. Southern medical journal, 1996, Volume: 89, Issue:10 Topics: Adult; Anticonvulsants; Body Surface Area; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cyclopho	1996
Nonconvulsive status epilepticus after intravenous contrast medium administration. Epilepsia, 1996, Volume: 37, Issue:11 Topics: Brain Neoplasms; Contrast Media; Diatrizoate Meglumine; Electroencephalography; Glioblastoma; Humans	1996
Late sequelae of treated pleomorphic xanthoastrocytoma: malignant brain stem astrocytoma occurring 15 years after radiation therapy. Journal of neuro-oncology, 1997, Volume: 32, Issue:1 Topics: Adolescent; Anticonvulsants; Astrocytoma; Brain Neoplasms; Brain Stem; Humans; Male; Neurologic Exam	1997
Phenytoin-related chorea in children with deep hemispheric vascular malformations. Journal of child neurology, 1996, Volume: 11, Issue:6 Topics: Adolescent; Anticonvulsants; Brain Neoplasms; Child; Chorea; Diagnostic Imaging; Female; Hemangioma,	1996
Anticonvulsant usage is associated with an increased risk of procarbazine hypersensitivity reactions in patients with brain tumors. Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:2 Topics: Adult; Anticonvulsants; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain	1997
The case of the dire desquamation. Stevens-Johnson syndrome. Postgraduate medicine, 1998, Volume: 103, Issue:1 Topics: Aged; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Cranial Irradiation; Fatal Outcome; Female	1998
A discriminant block among K+ channel types by phenytoin in neuroblastoma cells. British journal of pharmacology, 1998, Volume: 124, Issue:8 Topics: Animals; Anticonvulsants; Brain Neoplasms; Membrane Potentials; Neuroblastoma; Patch-Clamp Technique	1998
Comparing a mass-balance algorithm with a Bayesian regression analysis computer program for predicting serum phenytoin concentrations. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1998, Nov-15, Volume: 55, Issue:22 Topics: Algorithms; Anticonvulsants; Bayes Theorem; Brain Neoplasms; Female; Humans; Intracranial Arterioven	1998
[Drug-resistant epilepsy]. Revista de neurologia, 1998, Volume: 27, Issue:159 Topics: Adult; Anticonvulsants; Brain Neoplasms; Calcinosis; Carbamazepine; Diagnosis, Differential; Drug Re	1998
Allergic skin reactions to anticonvulsant medications in patients receiving cranial radiation therapy. Epilepsia, 1999, Volume: 40, Issue:3 Topics: Adolescent; Adult; Aged; Anticonvulsants; Astrocytoma; Brain Neoplasms; Drug Eruptions; Drug Therapy	1999
[Residual cerebellar ataxia following acute phenytoin intoxication]. Revue neurologique, 1999, Volume: 155, Issue:4 Topics: Adult; Anticonvulsants; Atrophy; Brain; Brain Neoplasms; Cerebellar Ataxia; Cerebellum; Epilepsy; Hu	1999
Transient MRI enhancement in a patient with seizures and previously resected glioma: use of MRS. Neurology, 1999, Jul-13, Volume: 53, Issue:1 Topics: Adult; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Carmustine; Combi	1999
Late radiation toxicity after whole brain radiotherapy: the influence of antiepileptic drugs. American journal of clinical oncology, 1999, Volume: 22, Issue:6 Topics: Actuarial Analysis; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anticonvulsants; Atrophy;	1999
Cytochrome P450-inducing antiepileptics increase the clearance of vincristine in patients with brain tumors. Clinical pharmacology and therapeutics, 1999, Volume: 66, Issue:6 Topics: Adult; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carbamazepi	1999
Cognitive deficits before treatment among patients with brain tumors. Neurosurgery, 2000, Volume: 47, Issue:2 Topics: Adult; Aged; Aging; Anticonvulsants; Brain Edema; Brain Neoplasms; Cognition; Cognition Disorders; D	2000
Anticonvulsant-induced suppression of IFN-gamma production by lymphocytes obtained from cervical lymph nodes in glioma-bearing mice. Journal of neuro-oncology, 2000, Volume: 47, Issue:2 Topics: Animals; Anticonvulsants; Brain; Brain Neoplasms; Disease Models, Animal; Glioma; Humans; Immunohist	2000
Rapacuronium administration to patients receiving phenytoin or carbamazepine. Journal of neurosurgical anesthesiology, 2001, Volume: 13, Issue:3 Topics: Adult; Anticonvulsants; Brain Injuries; Brain Neoplasms; Carbamazepine; Craniotomy; Drug Interaction	2001
Stevens-Johnson syndrome in a patient receiving anticonvulsant therapy during cranial irradiation. American journal of clinical oncology, 2001, Volume: 24, Issue:4 Topics: Adult; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Carcinoma, Ductal, Breast; Cranial Irradi	2001
Successful dexamethasone pulse therapy in a toxic epidermal necrolysis (TEN) patient featuring recurrent TEN to oxazepam. Clinical and experimental dermatology, 2001, Volume: 26, Issue:8 Topics: Anticonvulsants; Brain Neoplasms; Dexamethasone; Drug Therapy, Combination; Epidermis; Female; Gluco	2001
Altered irinotecan metabolism in a patient receiving phenytoin. Anti-cancer drugs, 2002, Volume: 13, Issue:2 Topics: Adult; Anticonvulsants; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Drug Inter	2002
Probable metabolic interaction of doxifluridine with phenytoin. The Annals of pharmacotherapy, 2002, Volume: 36, Issue:5 Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic	2002
Influence of phenytoin on the disposition of irinotecan: a case report. Journal of pediatric hematology/oncology, 2002, Volume: 24, Issue:2 Topics: Adolescent; Anticonvulsants; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy	2002
Phenytoin/dexamethasone interaction. Lancet (London, England), 1978, Jun-24, Volume: 1, Issue:8078 Topics: Brain Neoplasms; Dexamethasone; Drug Interactions; Glioblastoma; Humans; Methylprednisolone; Phenyto	1978
Anticonvulsant drugs and cancer. A cohort study in patients with severe epilepsy. Lancet (London, England), 1979, Sep-01, Volume: 2, Issue:8140 Topics: Adolescent; Adult; Brain Neoplasms; Child; England; Epilepsy; Female; Follow-Up Studies; Humans; Mal	1979
[Epilepsy--seizures are preventable]. Schwestern Revue, 1979, Dec-15, Volume: 17, Issue:12 Topics: Adult; Birth Injuries; Brain Damage, Chronic; Brain Injuries; Brain Neoplasms; Child; Epilepsy; Fema	1979
The Memorial Sloan-Kettering biomedical cyclotron facility:radioisotope production and labeled compounds. Progress in nuclear medicine, 1978, Volume: 4 Topics: Animals; Brain Neoplasms; Carbon Radioisotopes; Glioma; Haplorhini; Humans; Isotope Labeling; Macaca	1978
Transient hemiparesis: a rare manifestation of diphenylhydantoin toxicity. Report of two cases. Journal of neurosurgery, 1979, Volume: 50, Issue:5 Topics: Adult; Brain Neoplasms; Diagnosis, Differential; Female; Hemiplegia; Humans; Meningioma; Middle Aged	1979
Growth-inhibitory effect of diphenylhydantoin on murine astrocytomas. Neurosurgery, 1979, Volume: 5, Issue:2 Topics: Animals; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Cell Line; Colony-Forming Units Assay;	1979
The effect of phenobarbital pretreatment on the antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl-1-nitrosourea (PCNU), and on the plasma p The Journal of pharmacology and experimental therapeutics, 1979, Volume: 208, Issue:1 Topics: Alkylating Agents; Animals; Biotransformation; Brain Neoplasms; Carmustine; Dexamethasone; Drug Inte	1979
Effects of phenytoin on the release of 14C-adenine derivatives. Epilepsia, 1977, Volume: 18, Issue:3 Topics: Adenine; Animals; Astrocytoma; Brain Neoplasms; Carbamazepine; Cells, Cultured; Cerebral Cortex; Hyp	1977
[Brain stem seizures with circumscrbed elementary symptoms]. Der Nervenarzt, 1976, Volume: 47, Issue:9 Topics: Adult; Amitriptyline; Ataxia; Brain Neoplasms; Brain Stem; Carbamazepine; Epilepsy; Female; Humans;	1976
The excessively small ventricle on computed axial tomography of the brain. Neuroradiology, 1976, Volume: 12, Issue:3 Topics: Adolescent; Adult; Brain; Brain Concussion; Brain Diseases; Brain Neoplasms; Cerebral Ventriculograp	1976
Surgery of temporal lobe epilepsy. Advances in neurology, 1975, Volume: 8 Topics: Adolescent; Adult; Astrocytes; Brain Neoplasms; Cerebral Cortex; Child; Child, Preschool; Electroenc	1975
Astrocytoma in a dog causing convulsions. The Cornell veterinarian, 1975, Volume: 65, Issue:2 Topics: Animals; Astrocytoma; Brain; Brain Neoplasms; Dexamethasone; Dog Diseases; Dogs; Male; Phenytoin; Se	1975
Temporal-lobe seizures with additional foci treated by resection. Journal of neurosurgery, 1975, Volume: 43, Issue:5 Topics: Adolescent; Adult; Brain Neoplasms; Child; Electrodes, Implanted; Electroencephalography; Epilepsy,	1975
[2 patients with brain metastases who became pregnant during phenytoin administration]. Nederlands tijdschrift voor geneeskunde, 1992, Nov-07, Volume: 136, Issue:45 Topics: Abortion, Therapeutic; Adult; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Choriocarcinoma; Cont	1992
Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases. Journal of neurology, neurosurgery, and psychiatry, 1992, Volume: 55, Issue:11 Topics: Adolescent; Adult; Angiography; Brain Neoplasms; Carbamazepine; Cerebral Hemorrhage; Child; Epilepsy	1992
Phenytoin-induced agranulocytosis: a nonimmunologic idiosyncratic reaction? Acta haematologica, 1991, Volume: 86, Issue:4 Topics: Agranulocytosis; Brain Neoplasms; Carcinoma, Squamous Cell; Chemical and Drug Induced Liver Injury;	1991
Steroid-induced weakness in patients with primary brain tumors. Neurology, 1991, Volume: 41, Issue:8 Topics: Activities of Daily Living; Actuarial Analysis; Brain Neoplasms; Dexamethasone; Electromyography; Hu	1991
Interaction of dexamethasone with phenytoin. Pharmacotherapy, 1991, Volume: 11, Issue:4 Topics: Adenocarcinoma; Brain Edema; Brain Neoplasms; Dexamethasone; Drug Interactions; Humans; Male; Metabo	1991
Phenytoin-induced choreoathetosis. Postgraduate medical journal, 1990, Volume: 66, Issue:782 Topics: Athetosis; Brain Neoplasms; Chorea; Female; Glioma; Humans; Middle Aged; Phenytoin	1990
Acute phenytoin intoxication associated with the antineoplastic agent UFT. Fukuoka igaku zasshi = Hukuoka acta medica, 1990, Volume: 81, Issue:4 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; D	1990
Decreased phenytoin level after carboplatin treatment. The American journal of medicine, 1990, Volume: 89, Issue:2 Topics: Antineoplastic Agents; Brain Neoplasms; Carboplatin; Drug Interactions; Humans; Male; Middle Aged; O	1990
Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours. Acta neurochirurgica, 1990, Volume: 103, Issue:1-2 Topics: Adult; Anticonvulsants; Brain Neoplasms; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged;	1990
Cancer among epileptic patients exposed to anticonvulsant drugs. Journal of the National Cancer Institute, 1989, May-10, Volume: 81, Issue:10 Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Brain Neoplasms; Child; Child, Preschool; Denmark;	1989
Phenytoin induced fatal hepatic injury. Boletin de la Asociacion Medica de Puerto Rico, 1989, Volume: 81, Issue:9 Topics: Brain Neoplasms; Chemical and Drug Induced Liver Injury; Female; Humans; Meningioma; Middle Aged; Ph	1989
Phenytoin-induced orofacial dyskinesia. A case report. Journal of neurology, 1985, Volume: 231, Issue:6 Topics: Brain Neoplasms; Cerebral Cortex; Dyskinesia, Drug-Induced; Electroencephalography; Face; Glioblasto	1985
Phenytoin-induced resistance to pancuronium. Use of atracurium infusion in management of a neurosurgical patient. Anaesthesia, 1988, Volume: 43, Issue:9 Topics: Adolescent; Atracurium; Brain Neoplasms; Drug Interactions; Drug Tolerance; Epilepsy; Humans; Infusi	1988
Erythema multiforme and Stevens-Johnson syndrome in patients receiving cranial irradiation and phenytoin. Neurology, 1988, Volume: 38, Issue:2 Topics: Adult; Brain Neoplasms; Dysgerminoma; Erythema Multiforme; Humans; Male; Phenytoin; Radiation Injuri	1988
[Anticonvulsants in the therapy of glioblastomas]. Der Nervenarzt, 1986, Volume: 57, Issue:11 Topics: Adult; Anticonvulsants; Brain Neoplasms; Carbamazepine; Combined Modality Therapy; Drug Therapy, Com	1986
Ependymoblastoma associated with prenatal exposure to diphenylhydantoin and methylphenobarbitone. Cancer, 1985, May-01, Volume: 55, Issue:9 Topics: Brain Neoplasms; Child, Preschool; Ependymoma; Female; Frontal Lobe; Heterozygote; Humans; Maternal-	1985
Epilepsy in the elderly. Age and ageing, 1974, Volume: 3, Issue:4 Topics: Age Factors; Aged; Angiography; Brain Neoplasms; Cerebrovascular Disorders; Dementia; Electroencepha	1974
"Dilatin" overdosage. The Medical journal of Australia, 1968, Oct-12, Volume: 2, Issue:15 Topics: Anticonvulsants; Ataxia; Brain Neoplasms; Carbamazepine; Diagnosis, Differential; Dibenzazepines; Ep	1968
Tinnitus evaluation. American family physician, 1973, Volume: 8, Issue:3 Topics: Bone Conduction; Brain Neoplasms; Cerebellopontine Angle; Craniocerebral Trauma; Diazepam; Ear Neopl	1973
Diencephalic autonomic epilepsy caused by a neoplasm. The Journal of pediatrics, 1973, Volume: 83, Issue:2 Topics: Astrocytoma; Autonomic Nervous System; Brain Neoplasms; Diencephalon; Epilepsy; Female; Humans; Infa	1973
Epileptic pain. An uncommon manifestation with localizing value. Neurology, 1973, Volume: 23, Issue:5 Topics: Adenocarcinoma; Adult; Brain Neoplasms; Cerebral Angiography; Diazepam; Epilepsy; Female; Humans; Ma	1973
Myokymia and facial contraction in brain stem glioma. An electromyographic study. Archives of neurology, 1974, Volume: 30, Issue:6 Topics: Action Potentials; Adult; Brain Neoplasms; Carbamazepine; Diazepam; Edrophonium; Electromyography; F	1974
Seven-year "cure" of lung cancer with metastasis to the brain. JAMA, 1972, Apr-03, Volume: 220, Issue:1 Topics: Adenocarcinoma; Brain Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Phe	1972
Central electronystagmographic abnormalities. Archives of otolaryngology (Chicago, Ill. : 1960), 1970, Volume: 92, Issue:1 Topics: Adult; Barbiturates; Brain Neoplasms; Brain Stem; Central Nervous System; Central Nervous System Dis	1970

phenytoin and Benign Neoplasms, Brain