Page last updated: 2024-10-21

phenytoin and Aura

phenytoin has been researched along with Aura in 2565 studies

Research Excerpts

ExcerptRelevanceReference
"We sought to determine the effect of changing phenytoin therapy on bone mineral density (BMD) and 25-hydroxyvitamin D in patients with epilepsy."9.17Effect of switching hepatic enzyme-inducer antiepileptic drug to levetiracetam on bone mineral density, 25 hydroxyvitamin D, and parathyroid hormone in young adult patients with epilepsy. ( Geater, A; Leelawattana, R; Limapichat, K; Phabphal, K; Sathirapanya, P; Setthawatcharawanich, S, 2013)
"To evaluate the safety and tolerability of treatment with levetiracetam and determine the trough levels of levetiracetam in patients with traumatic brain injury (TBI) who are at high risk for posttraumatic epilepsy (PTE)."9.16Results of phase 2 safety and feasibility study of treatment with levetiracetam for prevention of posttraumatic epilepsy. ( Atabaki, SM; He, J; Herr, D; Klein, P; Levine, Z; McCarter, R; Natale, J; Nogay, C; Pearl, PL; Sandoval, F; Soldin, SJ; Trzcinski, S; Tsuchida, T; van den Anker, J, 2012)
"To evaluate topiramate (TPM) and phenytoin (PHT) monotherapy following rapid oral initiation in new-onset epilepsy."9.14Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new-onset epilepsy: a randomized double-blind clinical trial. ( Faught, E; Hulihan, J; Krumholz, A; Mao, L; Naritoku, D; Privitera, M; Ramsay, E; Schwarzman, L; Wiegand, F, 2010)
"To evaluate the efficacy and tolerability of the treatment with valproic acid (VPA) in patients with status epilepticus (SE) or acute repetitive seizures (ARS) comparing it with phenytoin (PHT) treatment."9.13Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin. ( Dabby, R; Gilad, R; Izkovitz, N; Lampl, Y; Rapoport, A; Sadeh, M; Weller, B, 2008)
"To evaluate the response to albendazole treatment in patients who had SSECTL and new onset seizures treated with antiepileptic drugs (AED) in a prospective clinical trial."9.13Albendazole therapy for single small enhancing CT lesions (SSECTL) in the brain in epilepsy. ( Chattopadhyay, A; Khandelwal, N; Sawhney, IM; Thussu, A, 2008)
" This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy."9.12Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021)
"The role of folic acid (5mg/day) in combination with oral hygiene measures (group II) vis-a-vis oral hygiene measures alone (group I) in prevention of phenytoin-induced gingival overgrowth was investigated in a one-year follow-up study on sixty, 8-13-year-old epileptic children receiving phenytoin."9.11Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect. ( Chawla, HS; Gauba, K; Goyal, A; Prasad, VN; Singhi, P, 2004)
"This study was designed to measure the effect of the addition of zonisamide on phenytoin pharmacokinetics under steady-state conditions in patients with epilepsy."9.11Lack of a clinically significant effect of zonisamide on phenytoin steady-state pharmacokinetics in patients with epilepsy. ( Garnett, WR; Levy, RH; Pan, WJ; Ragueneau-Majlessi, I; Rosenfeld, W; Schmerler, M; Shah, J, 2004)
"Remacemide hydrochloride is a low-affinity, non-competitive NMDA receptor channel blocker under investigation for the treatment of epilepsy."9.10Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 800 mg/day) in a B.I.D. regimen. ( Blume, WT; Guberman, A; Holdich, TA; Jones, MW; Lee, MA; Pillay, N; Veloso, F; Weaver, DF, 2002)
"Remacemide hydrochloride is a low-affinity, non-competitive N-methyl-D-aspartic acid (NMDA) receptor channel blocker, under investigation in epilepsy."9.10Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 1200 mg/day) in a Q.I.D. regimen. ( Betts, TA; Boddie, HG; Chadwick, DW; Crawford, PM; Holdich, TA; Lindstrom, P; Newman, PK; Soryal, I; Wroe, S, 2002)
"The authors assessed the effect of concomitant antiepileptic therapy on steady-state plasma concentrations of the new antiepileptic drug (AED) topiramate and the potential relation between topiramate plasma levels and side effects in a cohort of 116 patients with epilepsy."9.10Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs. ( Albani, F; Avoni, P; Baruzzi, A; Contin, M; Riva, R, 2002)
"To assess the extent to which adults with epilepsy were optimized and individualized on phenytoin monotherapy in the Western Cape, South Africa and to estimate the average optimized dose and serum phenytoin concentration, and the therapeutic range for this patient group."9.09Optimization of phenytoin therapy in adults with epilepsy in the Western Cape, South Africa. ( Folb, PI; Kies, BM; Seymour, MA; Valodia, PN, 1999)
"Changes in body weight were evaluated in 349 patients from a study comparing efficacy of add-on therapy with tiagabine (TGB), carbamazepine (CBZ) or phenytoin (PHT)."9.09Total percentage body weight changes during add-on therapy with tiagabine, carbamazepine and phenytoin. ( Bertrand, ME; Deaton, RL; Hogan, RE; Sommerville, KW, 2000)
"This prospective observational study explored the efficacy and tolerability of topiramate (TPM) in patients with refractory epilepsy attending a single outpatient clinic."9.09Topiramate in refractory epilepsy: a prospective observational study. ( Brodie, MJ; Sills, GJ; Stephen, LJ, 2000)
"The effects of temperature on binding characteristics of phenytoin (PHT) to serum proteins were determined in adult patients with epilepsy."9.09Effect of temperature on binding characteristics of phenytoin to serum proteins in monotherapy adult patients with epilepsy. ( Kanemaru, R; Kodama, H; Kodama, Y; Mitsuyama, Y; Shinozawa, S; Todaka, K, 2000)
"Fifty-four out-patients with epilepsy who had been taking phenytoin for more than one year were examined for gingival hyperplasia."9.08Phenytoin as a risk factor in gingival hyperplasia. ( Kolínová, M; Patzelová, V; Perlík, F; Zvárová, J, 1995)
"Our objective was to evaluate the patterns of malformations in children exposed in utero to phenytoin (DPH) and carbamazepine (CBZ) monotherapy, and to compare them prospectively with matched mother-child pairs exposed to nonteratogens, and to separate the effects of antiepileptic drugs (AEDs) from those of epilepsy by collecting groups of untreated epileptics and those treated with DPH and CBZ for conditions other than epilepsy."9.08Findings in children exposed in utero to phenytoin and carbamazepine monotherapy: independent effects of epilepsy and medications. ( Chitayat, D; Farkas, LD; Koren, G; Nulman, I; Scolnik, D, 1997)
"To examine the genetic polymorphism of CYP2C9 and CYP2C19 and its effect on the pharmacokinetics of phenytoin among 44 Japanese patients with epilepsy."9.08Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy. ( Furusho, K; Hashimoto, Y; Hattori, H; Inui, K; Odani, A; Otsuki, Y; Uwai, Y, 1997)
"To compare the effectiveness of monotherapy clobazam (CLB) to carbamazepine (CBZ) and phenytoin (PHT) in children with epilepsy."9.08Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy. ( , 1998)
"We measured the levels of estradiol (E2), total testosterone (TT) and free testosterone (FT) in 24 male patients with epilepsy receiving phenytoin (DPH), 21 male patients with epilepsy receiving cabamazepine (CBZ), 23 male epileptics receiving no treatment, and in 10 healthy age-matched male controls."9.07[Effects of phenytoin and cabamazepine on sex hormones in male patients with epilepsy: a controlled study]. ( Ma, S; Zhou, S, 1994)
"Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with behavioural measures before medication and after one and six months of treatment."9.07Psychiatric aspects of epilepsy in childhood treated with carbamazepine, phenytoin or sodium valproate: a random trial. ( Berg, I; Butler, A; Ellis, M; Foster, J, 1993)
"Twenty severely retarded institutionalized epileptic adults with phenytoin-induced gingival hyperplasia were divided into two groups and received a daily 3 mg capsule of either folic acid or lactose for 16 weeks in a randomized, double-blind, parallel study."9.07The administration of folic acid to institutionalized epileptic adults with phenytoin-induced gingival hyperplasia. A double-blind, randomized, placebo-controlled, parallel study. ( Beaver, WT; Bottomley, WK; Brown, RS; Di Stanislao, PT, 1991)
"Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with cognitive tests before medication and three subsequent times over a year."9.07Cognitive impairment in new cases of epilepsy randomly assigned to carbamazepine, phenytoin and sodium valproate. ( Berg, I; Butler, R; Forsythe, I; McGuire, R, 1991)
"Progabide, an experimental GABA-ergic antiepileptic drug, was given in a placebo-controlled double-blind cross-over trial to 19 adult patients with chronic partial epilepsy refractory to previous high-dose antiepileptic drug therapy."9.06Progabide for refractory partial epilepsy: a controlled add-on trial. ( Schmidt, D; Utech, K, 1986)
"In a double-blind trial of phenytoin for the prevention of postoperative epilepsy in craniotomy patients, epilepsy was observed in 7."9.05Postoperative epilepsy: a double-blind trial of phenytoin after craniotomy. ( Challen, RG; Frewin, DB; Hanieh, A; Hann, CS; North, JB; Penhall, RK, 1980)
"A double-blind trial of phenytoin therapy following craniotomy was performed to test the hypothesis that phenytoin is effective in reducing postoperative epilepsy."9.05Phenytoin and postoperative epilepsy. A double-blind study. ( Frewin, DB; Hanieh, A; North, JB; Penhall, RK; Taylor, WB, 1983)
"A double-blind cross-over trial between pheneturide and phenytoin in ninety-four outpatients with epilepsy is described."9.05A comparison of phenytoin and pheneturide in patients with epilepsy: a double-blind cross-over trial. ( Engler, C; English, JR; Fry, DE; Gawel, MJ; Gibberd, FB; Page, NG; Park, DM; Rose, FC; Scott, G, 1982)
"Despite the widespread use of phenytoin in the treatment of epilepsy, few studies have examined its effects on cognitive functioning."9.05Phenytoin and cognitive function: effects on normal volunteers and implications for epilepsy. ( Huppert, FA; Thompson, P; Trimble, M, 1981)
"To determine the influence of phenytoin (PHT) monotherapy on the serum levels of homocysteine (Hcy), folate and vitamin B12 in patients with epilepsy."9.01Effects of phenytoin on serum levels of homocysteine, vitamin B12, folate in patients with epilepsy: A systematic review and meta-analysis (PRISMA-compliant article). ( Chen, S; Xia, Z; Xu, H; Xu, S; Xu, Y; Zhang, N, 2019)
"To review the time to treatment failure, remission and first seizure with carbamazepine compared with phenytoin when used as monotherapy in people with focal onset seizures (simple or complex focal and secondarily generalised), or generalised onset tonic-clonic seizures (with or without other generalised seizure types)."9.01Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review. ( Marson, AG; Nevitt, SJ; Tudur Smith, C, 2019)
"Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are fatal adverse cutaneous drug reactions which may be induced by phenytoin (PHT) or lamotrigine (LTG)."8.91HLA-B*1502 increases the risk of phenytoin or lamotrigine induced Stevens-Johnson Syndrome/toxic epidermal necrolysis: evidence from a meta-analysis of nine case-control studies. ( Huo, J; Li, X; Mei, S; Wang, J; Yu, K; Zhao, Z; Zhu, Y, 2015)
"Small sample size, poor methodological quality and lack of data on important outcome measures prevent any meaningful conclusions regarding the efficacy and safety of sulthiame as monotherapy in epilepsy."8.90Sulthiame monotherapy for epilepsy. ( Marson, AG; Milburn-McNulty, P; Powell, G; Sills, GJ, 2014)
"To review the best evidence comparing oxcarbazepine and phenytoin when used as monotherapy in patients with epilepsy."8.83Oxcarbazepine versus phenytoin monotherapy for epilepsy. ( Marson, AG; Muller, M; Williamson, PR, 2006)
"Side effects of certain drugs such as cyclosporin A (CsA) and phenytoin may induce gingival overgrowth which in some instances become unacceptable to the patient because esthetic, functional, and other effects."8.80Reduction of severe gingival overgrowth in a kidney transplant patient by replacing cyclosporin A with tacrolimus. ( Arriba, L; de Andrés, A; Hernández, G; Lucas, M, 2000)
" In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i."8.02Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021)
"There was higher frequency of breakthrough seizures during immediate-release phenytoin capsule usage than during extended-release phenytoin capsule usage by epilepsy patients."7.96Budget Impact Analysis of Extended-Release Phenytoin Capsules Compared With Immediate-Release Phenytoin Capsules for Patients With Epilepsy in Thailand. ( Suthipinijtham, P; Tiamkao, S, 2020)
"To examine the influence of obesity and sex on phenytoin LDs."7.91Evaluation of Intravenous Phenytoin and Fosphenytoin Loading Doses: Influence of Obesity and Sex. ( Alaniz, C; Burghardt, D; DasGupta, R, 2019)
"Cerebellar ataxia is present in 40% of patients with epilepsy and chronic exposure to phenytoin."7.88Phenytoin-related ataxia in patients with epilepsy: clinical and radiological characteristics. ( Aeschlimann, DP; Aeschlimann, PC; Dennis, GJ; Grünewald, RA; Hadjivassiliou, M; Hoggard, N; Howell, SJ; Reuber, M; Shanmugarajah, PD, 2018)
"The goal of our study was to investigate the incidence of Stevens-Johnson syndrome (SJS), the frequency of SJS diagnosis, and the association between SJS and prior use of allopurinol, carbamazepine or phenytoin."7.88Incidence of Stevens-Johnson syndrome following combination drug use of allopurinol, carbamazepine and phenytoin in Taiwan: A case-control study. ( Cheng, CY; Cheng, FJ; Chuang, PC; Huang, YS; Pan, HY; Syu, FK, 2018)
" Phenytoin induced dystonia."7.88Phenytoin induced dystonia. ( Acar, T; Alkan, G; Çaksen, H; Cander, B; Ergin, M; Ertekin, B; Koçak, S, 2018)
"Phenytoin (PHE) and carbamazepine (CBZ) are first rank causative drugs that can induce drug rash with eosinophilia and systemic symptoms (DRESS) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)."7.88Evaluation of a lymphocyte transformation test and cytokine detection assay to identify phenytoin and carbamazepine provoked DRESS or SJS/TEN in epilepsy patients. ( Kumkamthornkul, P; Srinoulprasert, Y; Tansit, T; Tuchinda, P; Udnaen, S, 2018)
" He had been administered phenytoin and gabapentin for the treatment of symptomatic traumatic epilepsy 8 years before."7.88Hypothyroidism induced by phenytoin and gabapentin: A Case Report. ( Ishii, K; Miyake, Z; Tamaoka, A, 2018)
"We selected and screened for mutations a group of 24 epileptic patients who experienced significant gingival overgrowth following phenytoin therapy."7.85Lack of pathogenic mutations in SOS1 gene in phenytoin-induced gingival overgrowth patients. ( Consoli, F; De Luca, A; Di Bonaventura, C; Giallonardo, AT; Guida, V; Margiotti, K; Pascolini, G; Pizzuti, A, 2017)
"Recent adverse event reports have raised the question of increased angioedema risk associated with exposure to levetiracetam."7.85Risk of angioedema associated with levetiracetam compared with phenytoin: Findings of the observational health data sciences and informatics research network. ( Banda, JM; Duke, JD; Hripcsak, G; Jin, P; Khoma, Y; Reich, C; Ryan, PB; Schuemie, MJ; Schwalm, MS; Shah, NH; Suchard, MA; Wu, Y; Xu, H, 2017)
"The PPK model, using the power scaling of body weight, effectively elucidated the topiramate serum concentration profile ranging from pediatric to adult patients."7.85Population Pharmacokinetics of Topiramate in Japanese Pediatric and Adult Patients With Epilepsy Using Routinely Monitored Data. ( Ikeda, A; Ito, S; Matsubara, K; Sugimoto, M; Takeuchi, M; Yamamoto, S; Yano, I; Yonezawa, A, 2017)
"We aimed to explore the possible influence of CYP2C9 (*2, *3 and IVS8-109 A>T), CYP2C19 (*2, *3 and *17) and ABCB1 (1236C>T, 2677G>A/T and 3435C>T) on phenytoin (PHT) plasma concentrations in 64 Mexican Mestizo (MM) patients with epilepsy currently treated with PHT in mono- (n=25) and polytherapy (n=39)."7.83CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy. ( Dorado, P; Familiar-López, I; Fricke-Galindo, I; Jung-Cook, H; LLerena, A; López-López, M; Martínez-Juárez, IE; Monroy-Jaramillo, N; Ortega-Vázquez, A; Peñas-Lledó, E, 2016)
"To identify the factors influencing topiramate pharmacokinetics (PK) in a large population of adult patients with epilepsy using population PK analysis."7.83Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis. ( Bae, EK; Jang, IJ; Kim, TJ; Lee, J; Lee, KJ; Lee, SK; Moon, J; Shin, D; Shin, JW; Shin, YW, 2016)
"Although it has been reported that some antiepileptic drugs have inducing or inhibiting effects on lamotrigine (LTG) clearance, whether they have the same effects in Asian epilepsy patients as in those in other countries has not been clarified, especially in children."7.83The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy. ( Abe, S; Azuma, Y; Ishihara, N; Ito, Y; Itomi, K; Kidokoro, H; Kojima, S; Kurahashi, H; Kurahashi, N; Maruyama, K; Natsume, J; Negoro, T; Okumura, A; Suzuki, M; Takeuchi, T; Tsuji, T; Watanabe, K; Yamada, K; Yamamoto, H, 2016)
"Lamotrigine (LTG) is a widely used antiepileptic-drug (AED) for the treatment of epilepsy."7.81Effect of comedication on lamotrigine clearance in Korean epilepsy patients. ( Hong, SB; Joo, EY; Kim, HJ; Kim, TE; Lee, SY; Seo, DW, 2015)
"To examine the effects of cytochrome P450 3A4 (CYP3A4), cytochrome P450 3A5 (CYP3A5) and ATP-binding cassette sub-family B member 1 (ABCB1) genetic polymorphisms on carbamazepine (CBZ) plasma concentrations in Chinese patients with epilepsy using CBZ as monotherapy and bitherapy with phenytoin (PHT), phenobarbital (PB), or valproic acid (VPA)."7.81Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy. ( Liu, DQ; Ma, HY; Sheng, YH; Wang, C; Wang, P; Yin, T; Zhou, BT, 2015)
"Valproic acid (VPA), which is widely used to treat epilepsy, migraine, and bipolar disorder, can causes severe hyperammonemia."7.81Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy. ( Hirai, K; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y, 2015)
"A 12-year-old patient with refractory epilepsy syndrome presented with phenytoin toxicity, following a concomitant treatment with phenytoin, valproic acid, and lamotrigine."7.80Drug interaction between phenytoin and valproic acid in a child with refractory epilepsy: a case report. ( Carnevale, RC; Carvalho, IV; de Fátima Lopes Ambrósio, R; de Queiroz, RA; dos Reis, MC; Mazzola, PG; Moriel, P; Visacri, MB, 2014)
"Lacosamide (LCM), a new antiepileptic drug (AED) approved as adjunctive therapy for the treatment of patients with partial-onset seizures, has limited pharmacokinetic and drug interaction data."7.80Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs. ( Duncan, JS; Markoula, S; Patsalos, PN; Ratnaraj, N; Sander, JW; Teotonio, R, 2014)
"Valproic acid, which is widely used to treat various types of epilepsy, may cause severe hyperammonemia."7.804217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. ( Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Miyakawa, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R, 2014)
" Pentylenetetrazole (PTZ)-kindled and spontaneous model of epilepsy (EL) mice were used as models of chemically induced and spontaneous epilepsy, respectively."7.80Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models. ( Ohtsuki, S; Terasaki, T; Uchida, Y, 2014)
"To facilitate therapeutic monitoring of antiepileptic drugs (AEDs) by healthcare professionals for patients with epilepsy (PWE), we applied a GC-MS assay to measure three AEDs: carbamazepine (CBZ), phenytoin (PHT) and valproic acid (VPA) levels concurrently in one dried blood spot (DBS), and validated the DBS-measured levels to their plasma levels."7.80Clinical validation and implications of dried blood spot sampling of carbamazepine, valproic acid and phenytoin in patients with epilepsy. ( Ho, PC; Kong, ST; Kumar, PK; Lee, WB; Lim, SH; Ng, YL; Wang, HY; Wong, PS, 2014)
" Adults with a history of epilepsy who used a generic phenytoin and whose therapy was switched to another generic phenytoin between January 2012 and June 2013 were included (n = 80)."7.80Switching between phenytoin generics in patients with epilepsy may lead to increased risk of breakthrough seizure: chart analysis and practice recommendations. ( Chu, K; Jung, KH; Lee, SK; Lee, ST; Moon, J; Shin, JW, 2014)
"Cognitive impairment implicates many factors beyond phenytoin monotherapy in patients with epilepsy."7.79Association of apolipoprotein E ε4 allele with cognitive impairment in patients with epilepsy and interaction with phenytoin monotherapy. ( Ganesvaran, RA; Narmadha, MP; Palanisamy, A; Rajendran, NN, 2013)
"We recruited ambulatory young adults with epilepsy who were taking phenytoin."7.79The association between BsmI polymorphism and bone mineral density in young patients with epilepsy who are taking phenytoin. ( Geater, A; Leelawattana, R; Limapichart, K; Phabphal, K; Sathirapanya, P; Setthawatcharawanich, S; Thammakumpee, N; Witeerungrot, N, 2013)
"Phenytoin is known to be able to induce cerebellar atrophy in patients with epilepsy."7.79The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy. ( Borgio, JG; De Paola, L; Scola, RH; Silvado, C; Twardowschy, CA; Werneck, LC, 2013)
" The distribution of variant CYP2C9 alleles and prevalence of phenytoin adverse reactions were hereby investigated in a population of patients diagnosed with epilepsy."7.77CYP2C9 polymorphism in patients with epilepsy: genotypic frequency analyzes and phenytoin adverse reactions correlation. ( De Paola, L; Scola, RH; Silvado, CE; Twardowschy, CA; Werneck, LC, 2011)
" She was receiving phenytoin for epilepsy for 2 years."7.76Phenytoin induced vitamin D deficiency presenting as proximal muscle weakness. ( Aggarwal, A; Faridi, MM, 2010)
"Phenytoin, one of the most common antiepileptic drugs, is a major cause of antiepileptic drug hypersensitivity syndrome (AHS), which is a rare but potentially fatal complication."7.75Agranulocytosis following phenytoin-induced hypersensitivity syndrome. ( Imai, K; Ito, S; Oguni, H; Osawa, M; Sasaki, K; Shioda, M, 2009)
"To determine the utility and tolerability of levetiracetam (LEV) compared to phenytoin (PHT) in preventing clinical seizures in patients with subarachnoid hemorrhage (SAH)."7.75Utility of levetiracetam in patients with subarachnoid hemorrhage. ( Husain, AM; Shah, D, 2009)
"Phenytoin (PHT) is widely used to treat epilepsy in elderly patients, but information on its pharmacokinetics in this population is limited."7.74Phenytoin half-life and clearance during maintenance therapy in adults and elderly patients with epilepsy. ( Ahn, JE; Birnbaum, AK; Brundage, RC; Cloyd, JC; Conway, JM; Leppik, IE; Marino, SE; Musib, LC; Ramsay, RE; Rarick, JO; White, JR, 2008)
"Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) in Han Chinese, but not in Caucasian populations."7.74Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. ( Desudchit, T; Hirankarn, N; Kangwanshiratada, O; Korkij, W; Limotai, C; Locharernkul, C; Loplumlert, J; Shotelersuk, V; Suphapeetiporn, K; Tongkobpetch, S, 2008)
"Ecto-nucleotidases, one of the main mechanisms involved in the control of adenosine levels in the synaptic cleft, have shown increased activities after the pilocarpine model of epilepsy."7.74Antiepileptic drugs prevent changes induced by pilocarpine model of epilepsy in brain ecto-nucleotidases. ( Bogo, MR; Bonan, CD; Bruno, AN; Cognato, Gde P; da Silva, RS; Sarkis, JJ, 2007)
"To compare the temporal pattern of seizures after acute withdrawal of oxcarbazepine (OXC) and phenytoin (PHT) in the epilepsy monitoring unit (EMU)."7.74Temporal pattern of oxcarbazepine and phenytoin withdrawal seizures during epilepsy monitoring. ( Abou-Khalil, BW; Azar, NJ; Song, Y; Wang, L, 2008)
"This is the first report demonstrating an association between the SCN1A polymorphism and carbamazepine-resistant epilepsy."7.74Association between SCN1A polymorphism and carbamazepine-resistant epilepsy. ( Abe, T; Hori, M; Ishitsu, T; Nakagawa, K; Nakagawa, T; Seo, T, 2008)
" The purpose of this study was to investigate the afferent fiber system to the cerebellum in patients with phenytoin (PHT)-induced cerebellar atrophy in comparison with cerebellar atrophy of other etiologies by using DT-MRI."7.72Diffusion tensor MRI and fiber tractography of cerebellar atrophy in phenytoin users. ( Chu, M; Heo, K; Kim, DI; Kim, DJ; Kim, SY; Lee, BI; Lee, SK; Mori, S, 2003)
"Phenytoin-induced gingival overgrowth is a well-known and frequently reported gingival lesion, which was first detected in 1939."7.72Phenytoin-induced gingival overgrowth in un-cooperated epilepsy patients. ( Cakmak, H; Gursoy, UK; Marakoglu, I; Marakoglu, K, 2004)
"The effects of phenytoin (PHT) and phenobarbital (PHB) on EEG activity and behavior was studied in the model of epilepsy induced by intracerebroventricular (i."7.72The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats. ( Stanojlovic, O; Stojanovic, J; Susic, V; Zivanovic, D, 2004)
"To search for the optimal dosage of phenytoin in patients with epilepsy based on the metabolic activities of CYP2C9 and CYP2C19 polymorphisms, a total of 169 patients receiving phenytoin treatment for more than 1 month were recruited."7.72Dosage recommendation of phenytoin for patients with epilepsy with different CYP2C9/CYP2C19 polymorphisms. ( Chang, CJ; Chen, CC; Hung, CC; Lin, CJ; Liou, HH, 2004)
" The boy was exposed to phenytoin, in combination with carbamazepine, during pregnancy."7.71Chondrodysplasia punctata (CDP) with features of the tibia-metacarpal type and maternal phenytoin treatment during pregnancy. ( Annerén, G; Brandberg, G; Larsson, M; Lönnerholm, T; Wester, U, 2002)
"We report the case of a 24-y-old woman who presented with repeated episodes of otitis due to panhypogammaglobulinemia and low levels of mature CD19 + B cells (84 cells/microl) associated with phenytoin treatment."7.71Reversible panhypogammaglobulinemia associated with phenytoin treatment. ( Pereira, LF; Sanchez, JF, 2002)
"To determine the effects of temperature on binding characteristics of phenytoin to serum proteins in paediatric patients with epilepsy."7.71Effect of temperature on serum protein binding characteristics of phenytoin in monotherapy paediatric patients with epilepsy. ( Itokazu, N; Kanemaru, R; Kodama, H; Kodama, Y; Shinozawa, S; Sugimoto, T, 2001)
"To elucidate the involvement of bFGF (basic fibroblast growth factor) in the pathogenesis of phenytoin-induced gingival overgrowth, we measured the concentration of bFGF in the serum of 36 epileptic patients taking phenytoin and in 94 normal volunteers by enzyme-linked immunosorbent assay technique."7.70Increased bFGF level in the serum of patients with phenytoin-induced gingival overgrowth. ( Maita, E; Sasaki, T, 1998)
"The last premortem serum concentrations of phenobarbital (PB), phenytoin (PHT), carbamazepine (CBZ) and its CBZ-10,11-epoxide metabolite (CE) were compared with the corresponding postmortem serum concentrations in 16 adult patients of an epilepsy centre."7.70Comparison between premortem and postmortem serum concentrations of phenobarbital, phenytoin, carbamazepine and its 10,11-epoxide metabolite in institutionalized patients with epilepsy. ( Jürgens, U; May, T; Rambeck, B; Schnabel, R, 1999)
"A 30-year-old man was given high doses of phenytoin together with 4 antituberculous drugs for a seizure associated with a probable brain tuberculoma."7.70[Residual cerebellar ataxia following acute phenytoin intoxication]. ( al Beladi, K; al Jumah, M; Amene, P; Awada, A, 1999)
"The effects of temperature on the binding kinetics of phenytoin (PHT) to serum proteins were determined in patients with epilepsy."7.70Temperature effect on serum protein binding kinetics of phenytoin in monotherapy patients with epilepsy. ( Kanemaru, R; Kodama, H; Kodama, Y; Mitsuyama, Y; Shinozawa, S; Todaka, K, 1999)
"The potential effect of co-medication with phenobarbitone, primidone and carbamazepine on plasma and saliva concentrations of 5-(4-hydroxyphenyl)-5-phenylhydantoin (4-HPPH), the major metabolite of phenytoin in man and on the incidence of phenytoin-induced gingival overgrowth was investigated in a group of 36 adult epileptic patients."7.70The effect of multiple anticonvulsant therapy on the expression of phenytoin-induced gingival overgrowth. ( Ball, DE; Kamali, F; McLaughlin, WS; Seymour, RA, 1999)
"The chronic treatment with phenytoin or the acute intoxication by this drug may cause permanent cerebellar injury with atrophy of cerebellum vermis and hemispheres, which can be detected by neuroimaging studies."7.70[Dose-dependent relationship of chronic use of phenytoin and cerebellar atrophy in patients with epilepsy]. ( Cendes, F; Dantas, CD; Del Negro, A; Montenegro, MA; Zanardi, V, 2000)
"The aim of the present study was to determine the gender-related binding characteristics of phenytoin (PHT) to serum proteins in adult patients with epilepsy."7.70No gender effect on binding characteristics of phenytoin to serum proteins in monotherapy for adult patients with epilepsy. ( Kanemaru, R; Kodama, H; Kodama, Y; Mitsuyama, Y; Shinozawa, S; Todaka, K, 2000)
"We evaluated the effects of carbamazepine (CBZ) on serum androgen levels and sexual function prospectively for 5 years in 11 men with epilepsy and in 25 patients receiving either CBZ (14 patients) or phenytoin (PHT) (11) monotherapy for > 5 years."7.69Carbamazepine, phenytoin, sex hormones, and sexual function in men with epilepsy. ( Isojärvi, JI; Lukkarinen, O; Myllylä, VV; Pakarinen, AJ; Repo, M, 1995)
"Urinary excretions of carbamazepine, carbamazepine-10,11-epoxide, carbamazepine-10,11-trans-diol, 9-hydroxyacridan and 2- and 3-hydroxycarbamazepine were measured at various stages of pregnancy, and in the post-natal period, in ten epileptic women, six of whom took no other enzyme-inducing anticonvulsant and four of whom took such co-medication."7.69Metabolism of carbamazepine and co-administered anticonvulsants during pregnancy. ( Bernus, I; Dickinson, RG; Eadie, MJ; Hooper, WD, 1995)
"Cerebellar atrophy has been noted in patients with phenytoin exposure."7.69Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy. ( Barr, WB; Lantos, G; Ney, GC; Schaul, N, 1994)
"Phenytoin serum concentrations were evaluated in 88 epileptic women at different stages of pregnancy and 40 women during postnatal periods."7.69Phenytoin serum concentration monitoring during pregnancy and puerperium in Mexican epileptic women. ( Amancio-Chassin, O; Belmont-Gómez, A; Estrada-Altamirano, A; Hernández-Serrano, M; Herrerías-Cunedo, T; Rodríguez-Palomares, C, 1995)
"Topiramate, a structurally novel anticonvulsant, and phenytoin were evaluated in a rat model of ischemia-induced epilepsy."7.69Anticonvulsant activity of topiramate and phenytoin in a rat model of ischemia-induced epilepsy. ( Edmonds, HL; Jiang, YD; Shank, RP; Zhang, PY, 1996)
"The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36."7.69Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996)
"We examined the effect of CYP2C9/19 polymorphisms on the pharmacokinetics of phenytoin in 17 Japanese patients with epilepsy."7.69Effect of CYP2C polymorphisms on the pharmacokinetics of phenytoin in Japanese patients with epilepsy. ( Furusho, K; Hashimoto, Y; Hattori, H; Iui, K; Odani, A; Otsuki, Y; Takano, M, 1996)
"Twelve patients with epilepsy receiving chronic phenytoin therapy and 12 healthy control subjects matched for age and gender received a single oral dose of nisoldipine (40 and 20 mg, respectively)."7.69Reduced plasma nisoldipine concentrations in phenytoin-treated patients with epilepsy. ( Cipolla, G; Gatti, G; Heinig, R; Michelucci, R; Ochan, M; Passarelli, D; Perucca, E; Tassinari, CA, 1996)
"We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy."7.69BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. ( Morimoto, K; Sato, H; Sato, K; Sato, S; Yamada, N, 1997)
"Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline."7.68Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993)
"The steady-state 72 h urinary excretion of various phenytoin metabolites has been measured in 10 epileptic women, whose plasma phenytoin concentrations relative to the phenytoin dose fell during pregnancy and rose again post-partum."7.68Phenytoin metabolism during pregnancy. ( Dickinson, RG; Eadie, MJ; Hooper, WD; Lander, CM; McKinnon, GE, 1992)
"We retrospectively collected plasma level assessments performed in 96 adult patients with epilepsy on stable monotherapy, including 9 patients on clobazam (CLB), 34 on carbamazepine (CBZ), 24 on phenobarbital (PB), 9 on phenytoin (PHT), and 20 on valproate (VPA); these results were compared to those obtained in 54 adult patients on stable bitherapy with the association of CLB with either CBZ (n = 17), PB (n = 17), PHT (n = 5), or VPA (n = 15)."7.68Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy. ( Bonneton, J; Dravet, C; Genton, P; Mesdjian, E; Roger, J; Sennoune, S, 1992)
"We report the cases of four patients who were taking the anticonvulsant drugs phenytoin or carbamazepine and in whom skin lesions developed that showed histologic features suggestive of mycosis fungoides."7.68Mycosis fungoides-like lesions associated with phenytoin and carbamazepine therapy. ( Kruyswijk, MR; Meijer, CJ; Rijlaarsdam, U; Scheffer, E; Willemze, R, 1991)
"Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug."7.67Bioavailability and pharmacokinetics of phenytoin during pregnancy. ( Chalk, JB; de Wytt, C; Eadie, MJ; Lander, CM; Livingstone, I; Smith, MT; Symoniw, P, 1984)
"To assess the most efficient means of monitoring thyroid status in an epilepsy clinic, total thyroxine (T4), free thyroxine stimulating hormone (TSH) were measured in 71 adult patients treated long-term with either phenytoin (DPH), carbamazepine (CBZ) or sodium valproate (VAL)."7.67The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic. ( Borsey, DQ; Browning, MC; Connacher, AA; Davidson, DL; Jung, RT, 1987)
"We report the occurrence of bilateral cataracts in a young adult which developed shortly after documented high serum levels of phenytoin."7.67Development of presenile cataracts in association with high serum levels of phenytoin. ( Earll, J; Kattan, H; Lemp, M; Mathers, W, 1987)
"Report on a prospective longitudinal study of alterations in polygraphic sleep by phenytoin monotherapy for epilepsy."7.67Response of polygraphic sleep to phenytoin treatment for epilepsy. A longitudinal study of immediate, short- and long-term effects. ( Noachtar, S; Röder-Wanner, UU; Wolf, P, 1987)
"Reversible chronic cerebellar ataxia followed phenytoin treatment in two epileptic women."7.67Reversible chronic cerebellar ataxia after phenytoin intoxication: possible role of cerebellum in cognitive thought. ( Attig, E; Botez, MI; Gravel, J; Vézina, JL, 1985)
"Among 50 patients with phenytoin intoxication, 14 had seizures during the episode."7.67Incidence of seizures with phenytoin toxicity. ( Masdeu, JC; Stilman, N, 1985)
"Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered."7.66Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports. ( Arena, R; Bindi, A; Bonuccelli, U; De Scisciolo, G; Marcacci, G; Rossi, L, 1983)
"The problem of phenytoin-induced gingival hyperplasia is dicussed within the context of consultative planning between oral care practitioners and the physician managing the epilepsy."7.66Therapeutic alternatives in phenytoin-induced gingival hyperplasia. A case report and discussion. ( Kirkham, DB; Reynolds, NC, 1980)
"Sodium valproate is often used with phenytoin when epilepsy cannot be controlled by a single drug."7.66Phenytoin-valproate interaction: importance of saliva monitoring in epilepsy. ( Hamshaw-Thomas, A; Knott, C; Reynolds, F, 1982)
"The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)."7.66Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982)
"Cataracts developed in two young adults who were receiving prolonged antiepileptic treatment with phenobarbital sodium and phenytoin sodium."7.66Presenile cataracts in phenytoin-treated epileptic patients. ( Bar, S; Feller, N; Savir, H, 1983)
"Analysis of plasma phenytoin in a group of patients treated for epilepsy showed that only 36% had values in the therapeutic range."7.66Prediction of phenytoin dosage in epilepsy using multiple linear regression. ( Gray, SP, 1982)
" Using accepted CT criteria for the diagnosis of cerebellar atrophy, the films were analyzed in a blind, unbiased fashion to evaluate possible relationship between cerebellar atrophy and phenytoin use or epilepsy itself."7.66Cerebellar atrophy in epilepsy and headache: lack of relationship to phenytoin. ( Ballenger, CE; Brooks, BS; El Gammal, T; Green, JB; King, DW; Lucke, JF, 1982)
"1 Patients with poorly controlled epilepsy were cautiously transferred from multiple drug therapy to treatment with phenytoin sodium alone."7.66Serum phenytoin concentration and clinical response in patients with epilepsy. ( Gannaway, DJ; Mawer, GE, 1981)
"We describe a procedure for determining 2-ethyl-2-phenylmalonamide (I) in serum of epilepsy patients dosed with primidone (II) for seizure control, by extracting the sample with chloroform under basic conditions, with use of an internal standard, 2-ethyl-2-(p-tolyl)malonamide, and without derivative formation."7.66Monitoring 2-ethyl-2-phenylmalonamide in serum by gas-liquid chromatography: application to retrospective study in epilepsy patients dosed with primidone. ( Haidukewych, D; Rodin, EA, 1980)
"Nine cases of childhood epilepsy manifesting motor convulsions uncontrolled despite high levels of phenytoin (PHT) were studied clinically and electroencephalographically."7.66Childhood epilepsy uncontrolled by phenytoin: clinical and electroencephalographic study. ( Iinuma, K; Onuma, A; Tada, K; Takamatsu, N, 1979)
"Blood levels of phenytoin, total thyroxine, and free thyroxine were determined in 10 epileptic women during and following pregnancy."7.66Epilepsy and pregnancy. Serum thyroxine levels during phenytoin therapy. ( Ramsay, RE; Spellacy, WN; Strauss, RG; Wilder, BJ; Willmore, LJ, 1979)
"The effect of long-term phenytoin therapy on serum triglyceride and cholesterol levels in 20 patients with epilepsy was investigated."7.66Changes in serum triglyceride and cholesterol levels during long-term phenytoin treatment for epilepsy. ( Luoma, PV; Reunanen, MI; Sotaniemi, EA, 1979)
"Malignant mesenchymoma developed in an 18-year-old patient with phenytoin-associated cleft lip and palate."7.65Malignant mesenchymoma and birth defects. Prenatal exposure to phenytoin. ( Blattner, WA; Fraumeni, JF; Henson, DE; Young, RC, 1977)
"Cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and probenecid were examined in 14 children with epilepsy (ages 6 months to 17 years) and 17 controls (ages 14 months to 16 years)."7.65Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. ( Bowers, MB; Cohen, DJ; Shaywitz, BA, 1975)
"In vitro and in vivo immunologic studies were performed on a 28-year-old woman with phenytoin sodium-induced pseudolymphoma syndrome."7.65Phenytoin-induced pseudolymphoma syndrome: an immunologic study. ( Charlesworth, EN, 1977)
"Severe osteomalacia was present in two epileptic patients who were under long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide."7.65Acetazolamide-accelerated anticonvulsant osteomalacia. ( Mallette, LE, 1977)
"The relationship among the serum concentration of phenytoin, pneumoencephalographic measurements describing, in particular, cerebellar atrophy, and various other clinical variables was analyzed statistically in a series of 131 phenytoin-treated mentally retarded epileptics."7.65Cerebellar atrophy in phenytoin-treated mentally retarded epileptics. ( Helle, EP; Iivanainen, M; Viukari, M, 1977)
" Thirteen ambulant patients suffering from partial epilepsy with complex symptomatology, who were already being treated with phenytoin in optimal doses (plasma level 14-20 mug/ml) were also given carbamazepine."7.65Plasma levels of carbamazepine and carbamazepine-10,11-epoxide during treatment of epilepsy. ( Bertilsson, L; Eichelbaum, M; Lund, L; Palmér, L; Sjöqvist, F, 1976)
"Lamotrigine is an effective add-on therapy against a range of epileptic seizure types."6.69Lamotrigine monotherapy in newly diagnosed untreated epilepsy: a double-blind comparison with phenytoin. ( Abbott, R; Dellaportas, CI; Findley, LJ; Gibberd, FB; Gross, M; Park, DM; Perkin, GD; Steiner, TJ, 1999)
"Fosphenytoin was as well tolerated as intramuscular placebo at the injection site."6.68Safety and tolerance of multiple doses of intramuscular fosphenytoin substituted for oral phenytoin in epilepsy or neurosurgery. ( Campbell, K; Garnett, WR; Henkin, SA; Kugler, AR; Pellock, JM; Ramsay, RE; Wilder, BJ, 1996)
"The population pharmacokinetic parameters of phenytoin were estimated using routine therapeutic drug monitoring data from 116 epileptic patients."6.68Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: analysis with a dose-dependent clearance model. ( Furusho, K; Hashimoto, Y; Hattori, H; Inui, K; Koue, T; Odani, A; Otsuki, Y; Takano, M; Takayanagi, K; Yasuhara, M, 1996)
"1."6.66A multicentre study of vigabatrin for drug-resistant epilepsy. ( Ben-Menachem, E; Browne, TR; Mattson, RH; Miketta, RM; Penry, JK; Sherry, KM; Smith, DB; Szabo, GK; Treiman, DM; Wilder, BJ, 1989)
"Phenytoin has been widely prescribed alone; our results indicate that sodium valproate may also be used as a single drug in the treatment of several types of epilepsy."6.65Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy. ( Johnson, RH; Lambie, DG; Melville, ID; Nanda, RN; Shakir, RA, 1981)
"Phenytoin has been explored in over 100 different disorders; the last two promising indications tested in the clinic are breast cancer and optic neuritis."6.55Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action. ( Keppel Hesselink, JM; Kopsky, DJ, 2017)
"Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin."6.47Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011)
" The long-term use of phenytoin is not recommended for patients with loss of locomotion, marked cognitive impairment, or symptoms and signs of cerebellar disease."6.40Phenytoin: effective but insidious therapy for epilepsy in people with intellectual disability. ( Iivanainen, M, 1998)
"Plasma concentrations of lamotrigine, an antiepileptic drug obtained in three adult controlled clinical trials conducted in the United States were pooled and analyzed using NONMEM, a population pharmacokinetic computer program, to facilitate development of dosing guidelines."6.40Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy. ( Chen, C; Cox, E; Fiedler-Kelly, J; Grasela, TH; Risner, ME; Womble, GP, 1999)
"Valproic acid has become a regular component of antiepileptic therapy."6.36[Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)]. ( Fröscher, W; Gugler, R; Schulz, HU, 1978)
"Phenytoin (PHT) is a first-line antiepileptic drug in clinics, which could decrease neuronal bioelectric activity by blocking the voltage-operated sodium channels."5.91Calcium Phosphate-Based Nanoformulation Selectively Abolishes Phenytoin Resistance in Epileptic Neurons for Ceasing Seizures. ( Cao, D; Guan, Q; Li, M; Luo, Z; Mao, X; Wang, X, 2023)
"Epilepsy is a chronic neurological disorder that is characterized by episodes of seizure."5.72Clinical Evaluation of Levetiracetam in the Treatment of Epilepsy. ( Guan, S; Liu, J; Qian, F; Wang, Y; Wu, H; Yang, J, 2022)
"Lacosamide is a novel anticonvulsant that acts by enhancing sodium channel slow inactivation."5.56Therapeutic Monitoring of Lacosamide in Japanese Patients With Epilepsy: Clinical Response, Tolerability, and Optimal Therapeutic Range. ( Araki, Y; Fukushima, Y; Imai, K; Kagawa, Y; Takahashi, Y; Terada, K; Yamamoto, Y, 2020)
"Phenytoin has been decreasingly used because of the high interindividual variability in drug concentration and the narrow therapeutic window."5.51Optimal Dosing Regimen of Phenytoin for Korean Epilepsy Patients: From Premature Babies to the Elderly. ( Chae, D; Guk, J; Kim, JH; Lee, SG; Park, K, 2019)
" Phenobarbital versus levetiracetam as first-line ASM in EEG-confirmed neonatal seizures (one trial) Phenobarbital is probably more effective than levetiracetam in achieving seizure control after first loading dose (RR 2."5.41Anti-seizure medications for neonates with seizures. ( Abiramalatha, T; Brigo, F; Hartmann, H; Pressler, R; Ramaswamy, VV; Thanigainathan, S, 2023)
"Tamoxifen is a prodrug, requiring cytochrome P450 enzyme-mediated metabolism to form the active metabolite endoxifen."5.40Profound reduction in the tamoxifen active metabolite endoxifen in a patient on phenytoin for epilepsy compared with a CYP2D6 genotype matched cohort. ( Gryn, SE; Kim, RB; Teft, WA, 2014)
" P-gp polymorphisms may also affect phenytoin efficacy by altering its bioavailability (F)."5.39Studies on pharmacokinetic mechanism of phenytoin resistance in refractory epilepsy. ( Huang, JD; Huang, YS; Lai, ML; Tien, YE, 2013)
" Nevertheless, although the association of these genes with PTH-induced adverse effects has been well-documented in adult populations, this is the first report examining the influence of these genetic polymorphisms on PTH plasma levels and toxicity in a pediatric patient."5.39Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms. ( Dorado, P; Llerena, A; López-Torres, E; Martínez-Antón, J; Peñas-Lledó, EM, 2013)
"We determined PHT bioavailability during steady-state therapy by 1) measurement of the two principal deconjugated PHT urinary metabolites, 5-(4-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) and 5-(3,4-dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin (DHD); and 2) direct determination of absolute bioavailability after simultaneous administration of an oral formulation and parenteral stable-labeled PHT (SL-PHT)."5.37Excretion of the principal urinary metabolites of phenytoin and absolute oral bioavailability determined by use of a stable isotope in patients with epilepsy. ( Aliwarga, T; Brundage, RC; Cloyd, JC; Goel, V; Leppik, IE; Marino, SE; Remmel, RP, 2011)
" The drug combination elevated the plasma level of PHT in a patient on chemotherapy with capecitabine for colorectal cancer."5.37[A case of toxicity caused by drug interaction between capecitabine and phenytoin in patient with colorectal cancer]. ( Fukui, E; Kawahara, K; Sakurai, M; Ueda, R; Yamada, R, 2011)
"Curcumin was co-administered with sub-therapeutic dose of valproate 60min before PTZ injection."5.37Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. ( Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH, 2011)
"Phenytoin is a widely used anti-seizure agent, and a good correlation is observed between its concentration in plasma and the clinical effect."5.36Determination of free and total levels of phenytoin in human plasma from patients with epilepsy by MEKC: an adequate alternative to HPLC. ( Chen, SH; Hsieh, YH; Liao, FF; Lin, PC, 2010)
" The mean plasma drug concentrations at different time points and the pharmacokinetic parameters before and after piperine administration were compared by Student's t-test."5.33Effect of piperine on the steady-state pharmacokinetics of phenytoin in patients with epilepsy. ( Hota, D; Kharbanda, P; Pandhi, P; Pattanaik, S; Prabhakar, S, 2006)
"Oxcarbazepine was generally well tolerated during monotherapy and adjunctive therapy; 2."5.32Spotlight on oxcarbazepine in epilepsy. ( Bang, LM; Goa, KL, 2004)
"Levetiracetam has recently been approved as an adjunctive medication for partial seizures and frequently will be added to phenytoin."5.31Absence of pharmacokinetic drug interaction of levetiracetam with phenytoin in patients with epilepsy determined by new technique. ( Baltes, E; Browne, TR; Jensen, CM; Josephs, E; Leppik, IE; Paz, J; Szabo, GK, 2000)
" In addition, a population pharmacokinetic analysis was performed."5.30The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics. ( Higuchi, S; Ieiri, I; Imai, J; Mamiya, K; Ninomiya, H; Otsubo, K; Shimamoto, J; Tashiro, N; Yamada, H; Yukawa, E, 1998)
" PB was also the most toxic drug, followed by CBZ and by PHT."5.30Anticonvulsant and neurotoxic effects of intracerebroventricular injection of phenytoin, phenobarbital and carbamazepine in an amygdala-kindling model of epilepsy in the rat. ( Alós, M; Barcia, JA; Belda, V; Rubio, P; Serralta, A, 1999)
"Phenytoin toxicity is an uncommon problem seen in clinical practice."5.30Paradoxical seizures in phenytoin toxicity. ( Chua, HC; Tan, CB; Tjia, H; Venketasubramanian, N, 1999)
"Pregnant women with epilepsy on one or more of the following AEDs: lamotrigine, carbamazepine, phenytoin or levetiracetam."5.27AntiEpileptic drug Monitoring in PREgnancy (EMPiRE): a double-blind randomised trial on effectiveness and acceptability of monitoring strategies. ( Bagary, M; Coleman, J; D'Amico, M; Denny, E; Dodds, J; Eldridge, S; Greenhill, L; Hard, K; Kelso, A; Khan, KS; Marlin, N; McCorry, D; Middleton, L; Moss, N; Newton, S; Pirie, A; Pullen, A; Rikunenko, R; Roberts, T; Rogozińska, E; Thangaratinam, S; Weckesser, A, 2018)
"Phenobarbital may cause hyperactivity, behavioral problems, sedation, and even dementia; these effects are dose related to some extent."5.27Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy. ( Iivanainen, M; Savolainen, H, 1983)
"Oxazepam was more than 93% bound to serum proteins, but the extent of binding was not significantly different between the two groups."5.27Oxazepam pharmacokinetics in patients with epilepsy treated long-term with phenytoin alone or in combination with phenobarbitone. ( Hawksworth, GM; Khir, AS; Petrie, JC; Scott, AK; Steele, WH, 1983)
"Phenytoin treatment prevented the occurrence of convulsive and EEG seizures; however, lipid peroxidation was unaffected (16."5.27Effect of phenytoin and corticosteroids on seizures and lipid peroxidation in experimental posttraumatic epilepsy. ( Triggs, WJ; Willmore, LJ, 1984)
" Further, for dogs given phenobarbital, there was a sixfold variation between dosage and achieved serum concentration, whereas dogs given primidone manifested even greater variability between dosage and serum concentration."5.27Serum concentrations and efficacy of phenytoin, phenobarbital, and primidone in canine epilepsy. ( Farnbach, GC, 1984)
" In 48% of the patients the drug dosage had to be increased to combat the increased seizure frequency."5.27Serum phenytoin during pregnancy, labor and puerperium. ( Bardy, AH; Hiilesmaa, VK; Teramo, KA, 1987)
" Reducing the dosage by 19 mg/kg (A to B) decreased VPA plasma levels by 6."5.26Monitoring free valproic acid in epilepsy patients medicated with coanticonvulsants. ( Haidukewych, D; Rodin, EA, 1982)
"Carbamazepine was given to 152 patients who were receiving multiple drug therapy for uncontrolled seizures."5.26Role of carbamazepine in reducing polypharmacy in epilepsy. ( Maheshwari, MC; Padmini, R, 1981)
" Within the therapeutic range, small increments in dosage resulted in large increments in plasma DPH levels, and in the postpartum period high levels of DPH were encountered if the dosage was not reduced."5.26Phenytoin metabolism in pregnancy. ( Emery, MG; Kochenour, NK; Sawchuk, RJ, 1980)
"Patients with chronic renal failure had low plasma total, but disproportionately high plasma free, drug concentrations indicating impaired protein binding."5.26Salivary phenytoin concentrations in epilepsy and in chronic renal failure. ( Jones, NF; Reynolds, F; Smith, SE; Ziroyanis, PN, 1976)
" Although phenytoin dosage remained relatively constant, plasma phenytoin concentrations during pregnancy were significantly lower than nonpregnant concentrations."5.26Hematologic effects of phenytoin therapy during pregnancy. ( Ramsay, RE; Strauss, RG; Wilder, BJ; Willmore, LJ, 1978)
" When clinically indicated the daily dosage rate was adjusted by 50 mg steps until a serum concentration of 10--20 mg/l was produced."5.26Individual variation in daily dosage requirements for phenytoin sodium in patients with epilepsy. ( Barot, MH; Grant, RH; Maheendran, KK; Mawer, GE; Woodcock, BG, 1978)
"Steady-state serum-phenytoin levels were measured in five patients whose phenytoin dosage was changed three or more times for therapeutic purposes."5.25Serum-phenytoin levels in management of epilepsy. ( Dunlop, A; Richens, A, 1975)
"Phenytoin produced a lower serum level than the same dose of its sodium salt."5.25Systematic determination of the serum phenytoin level as an aid in the management of children with epilepsy. ( Gamstorp, I; Lilienberg, G; Norell, E, 1975)
"This article will review the different therapeutic options for status, from early treatment at home to the different first-line (benzodiazepines), second-line (phenobarbital, valproic acid, phenytoin, levetiracetam and lacosamide) or third-line treatments, which include both pharmacological (anaesthetics, propofol, ketamine, lidocaine, topiramate, brivaracetam or perampanel) and non-pharmacological (ketogenic diet, immunomodulatory treatments or epilepsy surgery) therapies."5.22[Paediatric status epilepticus]. ( García-Peñas, JJ; González-Alguacil, E; Soto-Insuga, V, 2022)
" Three groups of patients were studied: (A) epileptic under phenytoin monotherapy (n = 31); (B) with bipolar disorder under valproic acid treatment (n = 28); (C) elderly (n = 41)."5.22Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia. ( Fagiolino, P; González, R; Guevara, N; Maldonado, C; Queijo, C; Vázquez, M, 2016)
"We sought to determine the effect of changing phenytoin therapy on bone mineral density (BMD) and 25-hydroxyvitamin D in patients with epilepsy."5.17Effect of switching hepatic enzyme-inducer antiepileptic drug to levetiracetam on bone mineral density, 25 hydroxyvitamin D, and parathyroid hormone in young adult patients with epilepsy. ( Geater, A; Leelawattana, R; Limapichat, K; Phabphal, K; Sathirapanya, P; Setthawatcharawanich, S, 2013)
"In this prospective, observational, assessor-masked, multicentre study, we enrolled pregnant women with epilepsy on antiepileptic drug monotherapy (carbamazepine, lamotrigine, phenytoin, or valproate) between October, 1999, and February, 2004, at 25 epilepsy centres in the UK and the USA."5.17Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study. ( Baker, GA; Bromley, RL; Browning, N; Clayton-Smith, J; Cohen, MJ; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2013)
"Carbamazepine clearance was not associated with body weight or any parameterization of body size nor was age or race or any marker of hepatic or renal function in community dwelling elderly patients."5.16Population pharmacokinetics of carbamazepine in elderly patients. ( Birnbaum, AK; Brundage, RC; Collins, JF; Macias, FM; Punyawudho, B; Ramsay, ER, 2012)
"To evaluate the safety and tolerability of treatment with levetiracetam and determine the trough levels of levetiracetam in patients with traumatic brain injury (TBI) who are at high risk for posttraumatic epilepsy (PTE)."5.16Results of phase 2 safety and feasibility study of treatment with levetiracetam for prevention of posttraumatic epilepsy. ( Atabaki, SM; He, J; Herr, D; Klein, P; Levine, Z; McCarter, R; Natale, J; Nogay, C; Pearl, PL; Sandoval, F; Soldin, SJ; Trzcinski, S; Tsuchida, T; van den Anker, J, 2012)
"Phenytoin was associated with more fever and worse outcomes after intracerebral hemorrhage."5.14Anticonvulsant use and outcomes after intracerebral hemorrhage. ( Batjer, HH; Garg, RK; Levasseur, K; Liebling, S; Macken, MP; Naidech, AM; Schuele, SU, 2009)
"To evaluate topiramate (TPM) and phenytoin (PHT) monotherapy following rapid oral initiation in new-onset epilepsy."5.14Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new-onset epilepsy: a randomized double-blind clinical trial. ( Faught, E; Hulihan, J; Krumholz, A; Mao, L; Naritoku, D; Privitera, M; Ramsay, E; Schwarzman, L; Wiegand, F, 2010)
"To evaluate the efficacy and tolerability of the treatment with valproic acid (VPA) in patients with status epilepticus (SE) or acute repetitive seizures (ARS) comparing it with phenytoin (PHT) treatment."5.13Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin. ( Dabby, R; Gilad, R; Izkovitz, N; Lampl, Y; Rapoport, A; Sadeh, M; Weller, B, 2008)
"To evaluate the response to albendazole treatment in patients who had SSECTL and new onset seizures treated with antiepileptic drugs (AED) in a prospective clinical trial."5.13Albendazole therapy for single small enhancing CT lesions (SSECTL) in the brain in epilepsy. ( Chattopadhyay, A; Khandelwal, N; Sawhney, IM; Thussu, A, 2008)
" This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy."5.12Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021)
"The role of folic acid (5mg/day) in combination with oral hygiene measures (group II) vis-a-vis oral hygiene measures alone (group I) in prevention of phenytoin-induced gingival overgrowth was investigated in a one-year follow-up study on sixty, 8-13-year-old epileptic children receiving phenytoin."5.11Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect. ( Chawla, HS; Gauba, K; Goyal, A; Prasad, VN; Singhi, P, 2004)
"This study was designed to measure the effect of the addition of zonisamide on phenytoin pharmacokinetics under steady-state conditions in patients with epilepsy."5.11Lack of a clinically significant effect of zonisamide on phenytoin steady-state pharmacokinetics in patients with epilepsy. ( Garnett, WR; Levy, RH; Pan, WJ; Ragueneau-Majlessi, I; Rosenfeld, W; Schmerler, M; Shah, J, 2004)
"Subjects were 85 men with localization-related epilepsy (25 on carbamazepine [CBZ], 25 on phenytoin [PHT], 25 on lamotrigine [LTG], and 10 untreated for at least 6 months [no AED]) and 25 controls."5.11Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy. ( Bromfield, EB; Drislane, FW; Dworetzky, BA; Farina, EL; Frye, CA; Herzog, AG; Pennell, PB; Schomer, DL, 2005)
"Remacemide hydrochloride is a low-affinity, non-competitive NMDA receptor channel blocker under investigation for the treatment of epilepsy."5.10Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 800 mg/day) in a B.I.D. regimen. ( Blume, WT; Guberman, A; Holdich, TA; Jones, MW; Lee, MA; Pillay, N; Veloso, F; Weaver, DF, 2002)
"Remacemide hydrochloride is a low-affinity, non-competitive N-methyl-D-aspartic acid (NMDA) receptor channel blocker, under investigation in epilepsy."5.10Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 1200 mg/day) in a Q.I.D. regimen. ( Betts, TA; Boddie, HG; Chadwick, DW; Crawford, PM; Holdich, TA; Lindstrom, P; Newman, PK; Soryal, I; Wroe, S, 2002)
"The authors assessed the effect of concomitant antiepileptic therapy on steady-state plasma concentrations of the new antiepileptic drug (AED) topiramate and the potential relation between topiramate plasma levels and side effects in a cohort of 116 patients with epilepsy."5.10Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs. ( Albani, F; Avoni, P; Baruzzi, A; Contin, M; Riva, R, 2002)
"To determine whether biological maturation influences the kinetics of carbamazepine-serum protein binding, the carbamazepine free fraction (%) was investigated in the serum of 66 patients, ranging from 4 to 83 years, with epilepsy or trigeminal neuralgia, treated with carbamazepine alone or carbamazepine in combination with phenytoin, phenobarbital, and/or valproic acid, over a relatively long period."5.09Age-related alteration of carbamazepine-serum protein binding in man. ( Koyama, H; Mori, S; Nakajima, K; Sugioka, N; Uno, A, 1999)
"To assess the extent to which adults with epilepsy were optimized and individualized on phenytoin monotherapy in the Western Cape, South Africa and to estimate the average optimized dose and serum phenytoin concentration, and the therapeutic range for this patient group."5.09Optimization of phenytoin therapy in adults with epilepsy in the Western Cape, South Africa. ( Folb, PI; Kies, BM; Seymour, MA; Valodia, PN, 1999)
"Changes in body weight were evaluated in 349 patients from a study comparing efficacy of add-on therapy with tiagabine (TGB), carbamazepine (CBZ) or phenytoin (PHT)."5.09Total percentage body weight changes during add-on therapy with tiagabine, carbamazepine and phenytoin. ( Bertrand, ME; Deaton, RL; Hogan, RE; Sommerville, KW, 2000)
"This prospective observational study explored the efficacy and tolerability of topiramate (TPM) in patients with refractory epilepsy attending a single outpatient clinic."5.09Topiramate in refractory epilepsy: a prospective observational study. ( Brodie, MJ; Sills, GJ; Stephen, LJ, 2000)
"The effects of temperature on binding characteristics of phenytoin (PHT) to serum proteins were determined in adult patients with epilepsy."5.09Effect of temperature on binding characteristics of phenytoin to serum proteins in monotherapy adult patients with epilepsy. ( Kanemaru, R; Kodama, H; Kodama, Y; Mitsuyama, Y; Shinozawa, S; Todaka, K, 2000)
"We compared the cognitive effects of randomly prescribed phenytoin (PHT) and carbamazepine (CBZ) therapy on newly diagnosed patients with epilepsy in a 2-year parallel group follow-up study."5.08Comparing the cognitive effects of phenytoin and carbamazepine in long-term monotherapy: a two-year follow-up. ( Jokelainen, M; Pulliainen, V, 1995)
"Fifty-four out-patients with epilepsy who had been taking phenytoin for more than one year were examined for gingival hyperplasia."5.08Phenytoin as a risk factor in gingival hyperplasia. ( Kolínová, M; Patzelová, V; Perlík, F; Zvárová, J, 1995)
"Our objective was to evaluate the patterns of malformations in children exposed in utero to phenytoin (DPH) and carbamazepine (CBZ) monotherapy, and to compare them prospectively with matched mother-child pairs exposed to nonteratogens, and to separate the effects of antiepileptic drugs (AEDs) from those of epilepsy by collecting groups of untreated epileptics and those treated with DPH and CBZ for conditions other than epilepsy."5.08Findings in children exposed in utero to phenytoin and carbamazepine monotherapy: independent effects of epilepsy and medications. ( Chitayat, D; Farkas, LD; Koren, G; Nulman, I; Scolnik, D, 1997)
"To examine the genetic polymorphism of CYP2C9 and CYP2C19 and its effect on the pharmacokinetics of phenytoin among 44 Japanese patients with epilepsy."5.08Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy. ( Furusho, K; Hashimoto, Y; Hattori, H; Inui, K; Odani, A; Otsuki, Y; Uwai, Y, 1997)
"To compare the effectiveness of monotherapy clobazam (CLB) to carbamazepine (CBZ) and phenytoin (PHT) in children with epilepsy."5.08Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy. ( , 1998)
"We measured the levels of estradiol (E2), total testosterone (TT) and free testosterone (FT) in 24 male patients with epilepsy receiving phenytoin (DPH), 21 male patients with epilepsy receiving cabamazepine (CBZ), 23 male epileptics receiving no treatment, and in 10 healthy age-matched male controls."5.07[Effects of phenytoin and cabamazepine on sex hormones in male patients with epilepsy: a controlled study]. ( Ma, S; Zhou, S, 1994)
"A group of 51 patients with chronic cryptogenic or symptomatic localized epilepsy refractory to therapy with barbiturates underwent progressive substitution with phenytoin or carbamazepine, in standardized and randomized fashion."5.07Carbamazepine and phenytoin in epilepsies refractory to barbiturates: efficacy, toxicity and mental function. ( Antoniuk, SA; Bigarella, MM; Bittencourt, PR; da Costa, JC; Doro, MP; Ferreira, AS; Fonseca, LC; Gonçalves e Silva, GE; Gorz, AM; Marcourakis, T, 1993)
"Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with behavioural measures before medication and after one and six months of treatment."5.07Psychiatric aspects of epilepsy in childhood treated with carbamazepine, phenytoin or sodium valproate: a random trial. ( Berg, I; Butler, A; Ellis, M; Foster, J, 1993)
"The effects of the withdrawal of phenytoin (PT) on cognitive and psychomotor functions of long-term patients in an epilepsy centre were studied."5.07Effects of withdrawal of phenytoin on cognitive and psychomotor functions in hospitalized epileptic patients on polytherapy. ( Bulmahn, A; May, TW; Rambeck, B; Wohlhüter, M, 1992)
"A comparative study of the bioavailability of seven formulations of phenytoin was carried out on 17 patients with epilepsy who were taking phenytoin regularly as part of their drug therapy."5.07Bioavailability and dissolution of proprietary and generic formulations of phenytoin. ( Richens, A; Soryal, I, 1992)
"Twenty severely retarded institutionalized epileptic adults with phenytoin-induced gingival hyperplasia were divided into two groups and received a daily 3 mg capsule of either folic acid or lactose for 16 weeks in a randomized, double-blind, parallel study."5.07The administration of folic acid to institutionalized epileptic adults with phenytoin-induced gingival hyperplasia. A double-blind, randomized, placebo-controlled, parallel study. ( Beaver, WT; Bottomley, WK; Brown, RS; Di Stanislao, PT, 1991)
"Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with cognitive tests before medication and three subsequent times over a year."5.07Cognitive impairment in new cases of epilepsy randomly assigned to carbamazepine, phenytoin and sodium valproate. ( Berg, I; Butler, R; Forsythe, I; McGuire, R, 1991)
"We investigated the neuropsychological effects of carbamazepine, phenobarbital, and phenytoin in 15 partial complex epilepsy patients treated with each drug for 3 months, using a randomized double-blind, triple crossover design."5.06Comparative cognitive effects of anticonvulsants. ( Gallagher, BB; Huh, K; King, DW; Loring, DW; Meador, KJ, 1990)
"It has recently been reported that folic acid supplementation reduced DPH-induced gingival hyperplasia in cat and in a pilot study also in man."5.06Folate treatment of diphenylhydantoin-induced gingival hyperplasia. ( Bäckman, N; Blomquist, HK; Hänström, L; Heijbel, J; Holm, AK; Säfström, G, 1989)
" All the patients had epilepsy that had previously been untreated, and had been randomly assigned to receive carbamazepine, phenytoin, or sodium valproate."5.06Withdrawal of anticonvulsant drugs in patients free of seizures for two years. A prospective study. ( Callaghan, N; Garrett, A; Goggin, T, 1988)
"A prospective, double-blind, placebo-controlled investigation of possible withdrawal symptoms from phenytoin, carbamazepine and sodium valproate is reported in patients with active epilepsy, on combination therapy."5.06Withdrawal symptoms from phenytoin, carbamazepine and sodium valproate. ( Duncan, JS; Shorvon, SD; Trimble, MR, 1988)
"Progabide, an experimental GABA-ergic antiepileptic drug, was given in a placebo-controlled double-blind cross-over trial to 19 adult patients with chronic partial epilepsy refractory to previous high-dose antiepileptic drug therapy."5.06Progabide for refractory partial epilepsy: a controlled add-on trial. ( Schmidt, D; Utech, K, 1986)
"Introduction Phenytoin is a frequently used drug treatment for epilepsy."5.05An update on CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects. ( Carleton, BC; Chang, WC; Chung, WH; Hung, SI, 2020)
"In a double-blind trial of phenytoin for the prevention of postoperative epilepsy in craniotomy patients, epilepsy was observed in 7."5.05Postoperative epilepsy: a double-blind trial of phenytoin after craniotomy. ( Challen, RG; Frewin, DB; Hanieh, A; Hann, CS; North, JB; Penhall, RK, 1980)
"A double-blind trial of phenytoin therapy following craniotomy was performed to test the hypothesis that phenytoin is effective in reducing postoperative epilepsy."5.05Phenytoin and postoperative epilepsy. A double-blind study. ( Frewin, DB; Hanieh, A; North, JB; Penhall, RK; Taylor, WB, 1983)
"Eighty-eight patients with the onset of epilepsy in adult life were randomly allocated to treatment with sodium valproate (600 mg/day), or phenytoin (300 mg/day), and followed up for at least 12 months."5.05A comparison of phenytoin and valproate in previously untreated adult epileptic patients. ( Chadwick, DW; Rawlins, MD; Turnbull, DM; Weightman, D, 1982)
"A double-blind cross-over trial between pheneturide and phenytoin in ninety-four outpatients with epilepsy is described."5.05A comparison of phenytoin and pheneturide in patients with epilepsy: a double-blind cross-over trial. ( Engler, C; English, JR; Fry, DE; Gawel, MJ; Gibberd, FB; Page, NG; Park, DM; Rose, FC; Scott, G, 1982)
"A double blind trial of folic acid against placebo was carried out on out-patients with epilepsy treated with Phenytoin."5.05The influence of folic acid on the frequency of epileptic attacks. ( Gibberd, FB; Nicholls, A; Wright, MG, 1981)
"Despite the widespread use of phenytoin in the treatment of epilepsy, few studies have examined its effects on cognitive functioning."5.05Phenytoin and cognitive function: effects on normal volunteers and implications for epilepsy. ( Huppert, FA; Thompson, P; Trimble, M, 1981)
"The purpose of this clinical study was to evaluate the effect of a 3-min daily toothbrushing with 1% chlorhexidine gluconate toothpaste on dental plaque, gingivitis and gingival hyperplasia in 30 mentally retarded epileptic children treated with phenytoin."5.04Oral use of chlorhexidine gluconate toothpaste in epileptic children. ( Bay, LM; Russell, BG, 1978)
"In double blind crossover 4 month trials, carbamazepine was compared to phenytoin as sole treatment for 45 patients with uncontrolled partial and generalized epilepsy."5.04Carbamazepine and the electroencephalogram of epileptics: a double blind study in comparison to phenytoin. ( Dodrill, CB; Troupin, AS; Wilkus, RJ, 1978)
"To determine the influence of phenytoin (PHT) monotherapy on the serum levels of homocysteine (Hcy), folate and vitamin B12 in patients with epilepsy."5.01Effects of phenytoin on serum levels of homocysteine, vitamin B12, folate in patients with epilepsy: A systematic review and meta-analysis (PRISMA-compliant article). ( Chen, S; Xia, Z; Xu, H; Xu, S; Xu, Y; Zhang, N, 2019)
"To review the time to treatment failure, remission and first seizure with carbamazepine compared with phenytoin when used as monotherapy in people with focal onset seizures (simple or complex focal and secondarily generalised), or generalised onset tonic-clonic seizures (with or without other generalised seizure types)."5.01Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review. ( Marson, AG; Nevitt, SJ; Tudur Smith, C, 2019)
"Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are fatal adverse cutaneous drug reactions which may be induced by phenytoin (PHT) or lamotrigine (LTG)."4.91HLA-B*1502 increases the risk of phenytoin or lamotrigine induced Stevens-Johnson Syndrome/toxic epidermal necrolysis: evidence from a meta-analysis of nine case-control studies. ( Huo, J; Li, X; Mei, S; Wang, J; Yu, K; Zhao, Z; Zhu, Y, 2015)
" Antiepileptic drugs (AED) such as phenytoin are often used in clinical practice with the hopes of preventing post-traumatic epilepsy."4.91Pharmacological treatments for preventing epilepsy following traumatic head injury. ( Abel, H; Campbell, LA; Pohlmann-Eden, B; Thompson, K, 2015)
"Small sample size, poor methodological quality and lack of data on important outcome measures prevent any meaningful conclusions regarding the efficacy and safety of sulthiame as monotherapy in epilepsy."4.90Sulthiame monotherapy for epilepsy. ( Marson, AG; Milburn-McNulty, P; Powell, G; Sills, GJ, 2014)
"In this systematic review we present information relating to the effectiveness and safety of the following interventions: monotherapy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs (lamotrigine or levetiracetam) for drug-resistant epilepsy; and hemispherectomy for drug-resistant epilepsy."4.88Epilepsy (generalised). ( Maguire, M; Marson, AG; Ramaratnam, S, 2012)
"In this systematic review we present information relating to the effectiveness and safety of the following interventions: antiepileptic drugs after a single seizure; monotherapy for partial epilepsy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs for drug-resistant partial epilepsy (allopurinol, eslicarbazepine, gabapentin, lacosamide, lamotrigine, levetiracetam, losigamone, oxcarbazepine, retigabine, tiagabine, topiramate, vigabatrin, or zonisamide); antiepileptic drug withdrawal for people with partial or generalised epilepsy who are in remission; behavioural and psychological treatments for partial or generalised epilepsy (biofeedback, cognitive behavioural therapy (CBT), educational programmes, family counselling, relaxation therapy (alone or plus behavioural modification therapy, yoga); and surgery for drug-resistant temporal lobe epilepsy ( lesionectomy, temporal lobectomy, vagus nerve stimulation as adjunctive therapy)."4.87Epilepsy (partial). ( Maguire, M; Marson, AG; Ramaratnam, S, 2011)
"Long-term use of phenytoin (PHT) causes gingival hyperplasia; however, little is known about the oral side effects of other antiepileptic drugs (AEDs)."4.87The effects of antiepileptic drugs on oral health. ( Aragon, CE; Burneo, JG; Cornacchio, AL, 2011)
"In this systematic review we present information relating to the effectiveness and safety of the following interventions: monotherapy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs (lamotrigine or levetiracetam) for drug-resistant epilepsy; and hemispherectomy for drug-resistant epilepsy."4.86Epilepsy (generalised). ( Maguire, M; Marson, AG; Ramaratnam, S, 2010)
"In this systematic review we present information relating to the effectiveness and safety of the following interventions: antiepileptic drugs after a single seizure; monotherapy for partial epilepsy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs for drug-resistant partial epilepsy (allopurinol, eslicarbazepine, gabapentin, lacosamide, lamotrigine, levetiracetam, losigamone, oxcarbazepine, retigabine, tiagabine, topiramate, vigabatrin, or zonisamide); antiepileptic drug withdrawal for people with partial or generalised epilepsy who are in remission; behavioural and psychological treatments for partial or generalised epilepsy (biofeedback, cognitive behavioural therapy (CBT), educational programmes, family counselling, relaxation therapy (alone or plus behavioural modification therapy, yoga); and surgery for drug-resistant temporal lobe epilepsy ( lesionectomy, temporal lobectomy, vagus nerve stimulation as adjunctive therapy)."4.86Epilepsy (partial). ( Maguire, M; Marson, AG; Ramaratnam, S, 2010)
"To review the best evidence comparing oxcarbazepine and phenytoin when used as monotherapy in patients with epilepsy."4.83Oxcarbazepine versus phenytoin monotherapy for epilepsy. ( Marson, AG; Muller, M; Williamson, PR, 2006)
"The introduction of these new antiepileptic drugs, from felbamate to levetiracetam, raised hope of control of epilepsy with fewer adverse effects and improved quality of life."4.81New antiepileptic drug therapies. ( Bergin, AM; Connolly, M, 2002)
"The antiepileptic drug hypersensitivity syndrome (AHS) is an adverse drug reaction associated with the aromatic antiepileptic drugs (AEDs) phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), and primidone."4.80Antiepileptic drug hypersensitivity syndrome. ( Schlienger, RG; Shear, NH, 1998)
"Side effects of certain drugs such as cyclosporin A (CsA) and phenytoin may induce gingival overgrowth which in some instances become unacceptable to the patient because esthetic, functional, and other effects."4.80Reduction of severe gingival overgrowth in a kidney transplant patient by replacing cyclosporin A with tacrolimus. ( Arriba, L; de Andrés, A; Hernández, G; Lucas, M, 2000)
" Phenytoin has been used with much clinical success against all types of epileptiform seizures, except petit mal epilepsy, for over 50 years."4.79Basis of the antiseizure action of phenytoin. ( Tunnicliff, G, 1996)
"The major established drugs used in the management of epilepsy are carbamazepine, valproic acid, phenytoin, phenobarbital, primidone, ethosuximide and benzodiazepine drugs."4.79Established antiepileptic drugs. ( Perucca, E, 1996)
"This article provides an analysis of the degree of agreement between in vivo interaction studies performed in patients with epilepsy and healthy individuals, and in vitro studies which identified the cytochromes P450 (CYP) inhibited by felbamate and those involved in its metabolism."4.79Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation. ( Banfield, CR; Glue, P; Levy, RH; Mather, GG; Perhach, JL; Racha, JK, 1997)
"We present a case of a 29-year-old female with a history of epilepsy who was admitted for convulsive status epilepticus (CSE), which was controlled by intravenous VPA, as well as oral VPA and phenytoin."4.31Valproate-related hyperammonemic encephalopathy with generalized suppression EEG: a case report. ( Liu, X; Peng, X, 2023)
"This study was conducted to examine and verify the use of saliva as an alternative matrix for monitoring phenytoin drug levels in patients with epilepsy."4.02Use of Saliva as an Alternative Matrix to Serum/Plasma for Therapeutic Drug Monitoring Using Reverse-Phase HPLC. ( Ashraf, Z; Farhat, S; Rather, MY, 2021)
"The active drugs lamotrigine, oxcarbazepine, and phenobarbital were significantly associated with gingival overgrowth in 61%, 71%, and 53% of cases, respectively, and phenytoin, valproic acid, and carbamazepine in 50%, 44%, and 32% of cases, respectively."4.02Gingival overgrowth induced by anticonvulsant drugs: A cross-sectional study on epileptic patients. ( Bonvento, G; Gallo, C; Mucignat-Caretta, C; Zagotto, G, 2021)
" In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i."4.02Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021)
" In this study, we examined the effect of both acute and chronic treatment with moclobemide on seizures and the action of first-generation antiepileptic drugs: valproate, carbamazepine, phenobarbital and phenytoin."4.02Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice. ( Banach, M; Borowicz-Reutt, KK, 2021)
"There was higher frequency of breakthrough seizures during immediate-release phenytoin capsule usage than during extended-release phenytoin capsule usage by epilepsy patients."3.96Budget Impact Analysis of Extended-Release Phenytoin Capsules Compared With Immediate-Release Phenytoin Capsules for Patients With Epilepsy in Thailand. ( Suthipinijtham, P; Tiamkao, S, 2020)
" Epilepsy-associated comorbid depression was evaluated by tail suspension test, sucrose preference test, and plasma corticosterone levels, whereas epilepsy-associated memory deficit condition was assessed by step-through paradigm, Morris water maze, and nitrite levels."3.96Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice. ( Goel, RK; Kaur, S; Sharma, NK, 2020)
" She had a history of symptomatic epilepsy, which was successfully treated with phenytoin and phenobarbital."3.91Drug-drug interactions among drugs prescribed for nontuberculous mycobacterial infection and epilepsy: A case report. ( Hatanaka, M; Ikeda, R; Matsumoto, N; Oda, Y; Sonoda, J; Tazaki, T; Yoshikawa, N, 2019)
"To examine the influence of obesity and sex on phenytoin LDs."3.91Evaluation of Intravenous Phenytoin and Fosphenytoin Loading Doses: Influence of Obesity and Sex. ( Alaniz, C; Burghardt, D; DasGupta, R, 2019)
" As first-line drug phenobarbital was the most common choice, it was used in 79% of cases of acute symptomatic seizures, in 63% of structural epilepsy, in 42% of genetic epilepsies."3.91Influence of etiology on treatment choices for neonatal seizures: A survey among pediatric neurologists. ( Capovilla, G; Consonni, D; De Liso, P; Di Capua, M; Dilena, R; Falsaperla, R; Pisani, F; Pruna, D; Suppiej, A; Vitaliti, G, 2019)
" Pentylenetetrazole- (PTZ) and pilocarpine-induced seizures are well-established models of human epilepsy."3.91The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure. ( Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Rezaeian-Varmaziar, H; Shafaat, O, 2019)
"Cerebellar ataxia is present in 40% of patients with epilepsy and chronic exposure to phenytoin."3.88Phenytoin-related ataxia in patients with epilepsy: clinical and radiological characteristics. ( Aeschlimann, DP; Aeschlimann, PC; Dennis, GJ; Grünewald, RA; Hadjivassiliou, M; Hoggard, N; Howell, SJ; Reuber, M; Shanmugarajah, PD, 2018)
"The goal of our study was to investigate the incidence of Stevens-Johnson syndrome (SJS), the frequency of SJS diagnosis, and the association between SJS and prior use of allopurinol, carbamazepine or phenytoin."3.88Incidence of Stevens-Johnson syndrome following combination drug use of allopurinol, carbamazepine and phenytoin in Taiwan: A case-control study. ( Cheng, CY; Cheng, FJ; Chuang, PC; Huang, YS; Pan, HY; Syu, FK, 2018)
" Phenytoin induced dystonia."3.88Phenytoin induced dystonia. ( Acar, T; Alkan, G; Çaksen, H; Cander, B; Ergin, M; Ertekin, B; Koçak, S, 2018)
"Phenytoin (PHE) and carbamazepine (CBZ) are first rank causative drugs that can induce drug rash with eosinophilia and systemic symptoms (DRESS) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)."3.88Evaluation of a lymphocyte transformation test and cytokine detection assay to identify phenytoin and carbamazepine provoked DRESS or SJS/TEN in epilepsy patients. ( Kumkamthornkul, P; Srinoulprasert, Y; Tansit, T; Tuchinda, P; Udnaen, S, 2018)
" He had been administered phenytoin and gabapentin for the treatment of symptomatic traumatic epilepsy 8 years before."3.88Hypothyroidism induced by phenytoin and gabapentin: A Case Report. ( Ishii, K; Miyake, Z; Tamaoka, A, 2018)
"We selected and screened for mutations a group of 24 epileptic patients who experienced significant gingival overgrowth following phenytoin therapy."3.85Lack of pathogenic mutations in SOS1 gene in phenytoin-induced gingival overgrowth patients. ( Consoli, F; De Luca, A; Di Bonaventura, C; Giallonardo, AT; Guida, V; Margiotti, K; Pascolini, G; Pizzuti, A, 2017)
"A 71-year-old male with history of epilepsy was admitted for seizures and traumatic brain injury and intravenous fosphenytoin and levetiracetam were initiated."3.85Fosphenytoin-induced purple glove syndrome: A case report. ( Blunck, JR; Croom, JE; Fields, RK; Newman, JW, 2017)
"Recent adverse event reports have raised the question of increased angioedema risk associated with exposure to levetiracetam."3.85Risk of angioedema associated with levetiracetam compared with phenytoin: Findings of the observational health data sciences and informatics research network. ( Banda, JM; Duke, JD; Hripcsak, G; Jin, P; Khoma, Y; Reich, C; Ryan, PB; Schuemie, MJ; Schwalm, MS; Shah, NH; Suchard, MA; Wu, Y; Xu, H, 2017)
"Phenytoin monotherapy may cause a significant increase in the levels of serum homocysteine and a significant decrease in the serum folate and vitamin B12 levels in children with epilepsy, and the significant changes in above mentioned parameters occur early in the course of treatment."3.85Homocysteine Metabolism and Hematological Parameters in Early Stage of Phenytoin Treated Epileptic Children. ( Sharma, TK; Sitaraman, S; Vardey, SK, 2017)
"Sotalol as a drug blocking β-receptors and potassium KCNH2 channels may interact with different substances that affect seizures."3.85Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model. ( Banach, M; Borowicz-Reutt, KK; Popławska, M, 2017)
"5 times lower than the currently available enzyme-multiplied immunoassay technique (EMIT) for measurement of phenytoin in epilepsy patients."3.85Therapeutic Drug Monitoring of Phenytoin by Simple, Rapid, Accurate, Highly Sensitive and Novel Method and Its Clinical Applications. ( Guo, R; Shaikh, AS, 2017)
"In this cross-sectional observational study we enrolled consecutive children aged 2-12 years with epilepsy who had received phenytoin or carbamazepine monotherapy for >6 months."3.85Hyperhomocysteinaemia in children receiving phenytoin and carbamazepine monotherapy: a cross-sectional observational study. ( Attri, SV; Chandrasekaran, S; Patil, S; Sahu, JK; Sankhyan, N; Singhi, P; Suthar, R; Tageja, M, 2017)
"The PPK model, using the power scaling of body weight, effectively elucidated the topiramate serum concentration profile ranging from pediatric to adult patients."3.85Population Pharmacokinetics of Topiramate in Japanese Pediatric and Adult Patients With Epilepsy Using Routinely Monitored Data. ( Ikeda, A; Ito, S; Matsubara, K; Sugimoto, M; Takeuchi, M; Yamamoto, S; Yano, I; Yonezawa, A, 2017)
"After excluding patients in the monotherapy group with vascular etiology or previous cardiovascular events, in the remaining 400 patients, enzyme-inducer AEDs (EIAEDs), especially phenytoin (PHT), were associated with higher prevalence of dyslipidemia (PRa 1."3.85Prevalence of cardiovascular risk factors in people with epilepsy. ( Díez, L; Elosua, R; Gomez, A; Moreira, A; Roquer, J; Vivanco-Hidalgo, RM, 2017)
"We aimed to explore the possible influence of CYP2C9 (*2, *3 and IVS8-109 A>T), CYP2C19 (*2, *3 and *17) and ABCB1 (1236C>T, 2677G>A/T and 3435C>T) on phenytoin (PHT) plasma concentrations in 64 Mexican Mestizo (MM) patients with epilepsy currently treated with PHT in mono- (n=25) and polytherapy (n=39)."3.83CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy. ( Dorado, P; Familiar-López, I; Fricke-Galindo, I; Jung-Cook, H; LLerena, A; López-López, M; Martínez-Juárez, IE; Monroy-Jaramillo, N; Ortega-Vázquez, A; Peñas-Lledó, E, 2016)
"To identify the factors influencing topiramate pharmacokinetics (PK) in a large population of adult patients with epilepsy using population PK analysis."3.83Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis. ( Bae, EK; Jang, IJ; Kim, TJ; Lee, J; Lee, KJ; Lee, SK; Moon, J; Shin, D; Shin, JW; Shin, YW, 2016)
"Although it has been reported that some antiepileptic drugs have inducing or inhibiting effects on lamotrigine (LTG) clearance, whether they have the same effects in Asian epilepsy patients as in those in other countries has not been clarified, especially in children."3.83The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy. ( Abe, S; Azuma, Y; Ishihara, N; Ito, Y; Itomi, K; Kidokoro, H; Kojima, S; Kurahashi, H; Kurahashi, N; Maruyama, K; Natsume, J; Negoro, T; Okumura, A; Suzuki, M; Takeuchi, T; Tsuji, T; Watanabe, K; Yamada, K; Yamamoto, H, 2016)
"We compared persistence of antiepileptic drugs (AEDs) including carbamazepine, oxcarbazepine, gabapentin, lamotrigine, topiramate, valproic acid, and phenytoin in an Asian population with epilepsy."3.83Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study. ( Hsieh, CY; Huang, CW; Lai, EC; Lin, SJ; Setoguchi, S; Su, CC; Yang, YK, 2016)
" This compound was effective in delaying onset of PTZ-evoked seizures at the dose of 5mg/kg in kindled animals and significantly reduced oxidative stress better than standard drug phenobarbital (PB)."3.81Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents. ( Kumari, S; Mishra, CB; Tiwari, M, 2015)
"Lamotrigine (LTG) is a widely used antiepileptic-drug (AED) for the treatment of epilepsy."3.81Effect of comedication on lamotrigine clearance in Korean epilepsy patients. ( Hong, SB; Joo, EY; Kim, HJ; Kim, TE; Lee, SY; Seo, DW, 2015)
"Phenytoin has a widespread use in epilepsy treatment and is mainly metabolized by hepatic cytochrome P450 enzymes (CYP)."3.81The effect of polymorphic metabolism enzymes on serum phenytoin level. ( Ergeç, D; Gulcebi, MI; Guney, I; Onat, FY; Ozkara, C; Ozkaynakci, A; Ulucan, K; Uzan, M, 2015)
" We genotyped normal and epileptic patient cohorts of monoethnic population of Kashmir valley for CYP2C9 gene and allelic polymorphism and investigated the effect of CYP2C9*2 and *3 polymorphism on the Pharmacokinetic and therapeutic and/or adverse pharmacodynamic responses to Phenytoin in the idiopathic epilepsy patients."3.81Clinical relevance of genetic polymorphism in CYP2C9 gene to pharmacodynamics and pharmacokinetics of phenytoin in epileptic patients: validatory pharmacogenomic approach to pharmacovigilance. ( Andrabi, KI; Jan, TR; Kousar, S; Wafai, ZA; Wani, MA, 2015)
" We evaluated influence of DHA on anticonvulsant activity of AEDs phenytoin, valproate, and lamotrigine in maximal electroshock (MES), pentylenetetrazole (PTZ), and kindling models of epilepsy."3.81Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. ( Babapour, V; Gavzan, H; Sardari, S; Sayyah, M, 2015)
"Phenytoin has a narrow therapeutic window and seizures can occur at both ends of the spectrum."3.81Paradoxical Seizure Response to Phenytoin in an Epileptic Heroin Addict. ( Dewberry, RG; Pula, T; Vasagar, B; Verma, BR, 2015)
"A 49-year-old-male has been treated with phenytoin for epilepsy for more than ten years."3.81Potentially Unsafe Herb-drug Interactions Between a Commercial Product of Noni Juice and Phenytoin- A Case Report. ( Chen, MH; Kang, YC; Lai, SL, 2015)
"To examine the effects of cytochrome P450 3A4 (CYP3A4), cytochrome P450 3A5 (CYP3A5) and ATP-binding cassette sub-family B member 1 (ABCB1) genetic polymorphisms on carbamazepine (CBZ) plasma concentrations in Chinese patients with epilepsy using CBZ as monotherapy and bitherapy with phenytoin (PHT), phenobarbital (PB), or valproic acid (VPA)."3.81Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy. ( Liu, DQ; Ma, HY; Sheng, YH; Wang, C; Wang, P; Yin, T; Zhou, BT, 2015)
"Valproic acid (VPA), which is widely used to treat epilepsy, migraine, and bipolar disorder, can causes severe hyperammonemia."3.81Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy. ( Hirai, K; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y, 2015)
"A 12-year-old patient with refractory epilepsy syndrome presented with phenytoin toxicity, following a concomitant treatment with phenytoin, valproic acid, and lamotrigine."3.80Drug interaction between phenytoin and valproic acid in a child with refractory epilepsy: a case report. ( Carnevale, RC; Carvalho, IV; de Fátima Lopes Ambrósio, R; de Queiroz, RA; dos Reis, MC; Mazzola, PG; Moriel, P; Visacri, MB, 2014)
"Lacosamide (LCM), a new antiepileptic drug (AED) approved as adjunctive therapy for the treatment of patients with partial-onset seizures, has limited pharmacokinetic and drug interaction data."3.80Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs. ( Duncan, JS; Markoula, S; Patsalos, PN; Ratnaraj, N; Sander, JW; Teotonio, R, 2014)
"The "anticonvulsant face," with a short nose, broad nasal bridge, epicanthal folds, and wide mouth, was described in the 1970s in children who had been exposed during pregnancy to the anticonvulsant drugs phenytoin and phenobarbital."3.80Laser light scan analysis of the "anticonvulsant face". ( Deutsch, CK; Holmes, LB; Orup, HI, 2014)
"Valproic acid, which is widely used to treat various types of epilepsy, may cause severe hyperammonemia."3.804217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. ( Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Miyakawa, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R, 2014)
" Pentylenetetrazole (PTZ)-kindled and spontaneous model of epilepsy (EL) mice were used as models of chemically induced and spontaneous epilepsy, respectively."3.80Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models. ( Ohtsuki, S; Terasaki, T; Uchida, Y, 2014)
"To facilitate therapeutic monitoring of antiepileptic drugs (AEDs) by healthcare professionals for patients with epilepsy (PWE), we applied a GC-MS assay to measure three AEDs: carbamazepine (CBZ), phenytoin (PHT) and valproic acid (VPA) levels concurrently in one dried blood spot (DBS), and validated the DBS-measured levels to their plasma levels."3.80Clinical validation and implications of dried blood spot sampling of carbamazepine, valproic acid and phenytoin in patients with epilepsy. ( Ho, PC; Kong, ST; Kumar, PK; Lee, WB; Lim, SH; Ng, YL; Wang, HY; Wong, PS, 2014)
" Adults with a history of epilepsy who used a generic phenytoin and whose therapy was switched to another generic phenytoin between January 2012 and June 2013 were included (n = 80)."3.80Switching between phenytoin generics in patients with epilepsy may lead to increased risk of breakthrough seizure: chart analysis and practice recommendations. ( Chu, K; Jung, KH; Lee, SK; Lee, ST; Moon, J; Shin, JW, 2014)
" He had a complex medical history including epilepsy controlled with long-term phenytoin."3.79When less is more: a case of phenytoin toxicity. ( Arnold, I; Robertson, K; von Stempel, CB, 2013)
"We report two cases of drug rash with eosinophilia and systemic symptoms (DRESS) associated with the use of carbamazepine and phenytoin in Brazilian boys tested for human leukocyte antigen (HLA) class I and II alleles."3.79HLA typing in Brazilian boys with aromatic antiepileptic drug-induced DRESS. ( Cuman, RK; Gaeti, WP; Moliterno, RA; Obreli-Neto, PR; Schiavon, GB, 2013)
"The results indicated an increased risk of hypothyroidism among patients using AEDs, especially phenytoin, valproate, phenobarbital, carbamazepine, and oxcarbazepine."3.79Use of antiepileptic drugs and risk of hypothyroidism. ( Hsieh, CY; Lai, EC; Lin, SJ; Yang, YH, 2013)
"Cognitive impairment implicates many factors beyond phenytoin monotherapy in patients with epilepsy."3.79Association of apolipoprotein E ε4 allele with cognitive impairment in patients with epilepsy and interaction with phenytoin monotherapy. ( Ganesvaran, RA; Narmadha, MP; Palanisamy, A; Rajendran, NN, 2013)
"We recruited ambulatory young adults with epilepsy who were taking phenytoin."3.79The association between BsmI polymorphism and bone mineral density in young patients with epilepsy who are taking phenytoin. ( Geater, A; Leelawattana, R; Limapichart, K; Phabphal, K; Sathirapanya, P; Setthawatcharawanich, S; Thammakumpee, N; Witeerungrot, N, 2013)
"Phenytoin is known to be able to induce cerebellar atrophy in patients with epilepsy."3.79The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy. ( Borgio, JG; De Paola, L; Scola, RH; Silvado, C; Twardowschy, CA; Werneck, LC, 2013)
"Clinical studies indicate that phenytoin prevents acute post-traumatic seizures but not subsequent post-traumatic epilepsy."3.78Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro. ( Berdichevsky, Y; Dzhala, V; Mail, M; Staley, KJ, 2012)
"We recruited 98 patients with epilepsy (45 taking phenytoin, 27 taking valproate, and 26 not taking any AED)."3.78Characterization of glucose homeostasis and lipid profile in adult, seizure-free, epileptic patients in Asian population. ( Geater, A; Limapichat, K; Phabphal, K; Sathirapanya, P; Setthawatcharawanich, S, 2012)
"Asians who carry the HLA-B*1502 allele have an elevated risk of developing Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) when treated with the antiepileptic drugs (AEDs) carbamazepine (CBZ) and phenytoin (PHT)."3.78Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore. ( Dong, D; Finkelstein, EA; Sung, C, 2012)
" Using this assay, we examined polymorphisms in 20 Japanese pediatric patients prescribed phenytoin for the treatment of epilepsy, and classified their polymorphisms into four groups: group I, CYP2C9*1/*1 and CYP2C19*1/*1; group II, CYP2C9*1/*1 and CYP2C19*1/*2 or *1/*3; group III, CYP2C9*1/*1 and CYP2C19*2/*2; and group IV, CYP2C9*1/*3 and CYP2C19*1/*2 or *1/*3."3.77[Development of rapid genotyping methods for single nucleotide polymorphisms of cytochrome P450 2C9 (CYP2C9) and cytochrome P450 2C19 (CYP2C19) and their clinical application in pediatric patients with epilepsy]. ( Ikumi, Y; Kagawa, Y; Mishima, N; Nishimura, S; Takahashi, Y; Yamamoto, Y, 2011)
" The distribution of variant CYP2C9 alleles and prevalence of phenytoin adverse reactions were hereby investigated in a population of patients diagnosed with epilepsy."3.77CYP2C9 polymorphism in patients with epilepsy: genotypic frequency analyzes and phenytoin adverse reactions correlation. ( De Paola, L; Scola, RH; Silvado, CE; Twardowschy, CA; Werneck, LC, 2011)
"A retrospective cohort study using a large health insurance plan claims database comparing patients with epilepsy who switched from brand to generic equivalent phenytoin, lamotrigine, or divalproex after 6 months (switch cohorts) to matched patients who remained on the brand (nonswitch cohorts)."3.77Clinical and pharmacy utilization outcomes with brand to generic antiepileptic switches in patients with epilepsy. ( Curtis, B; Erickson, SC; Harada, AS; Le, L; Ramsey, SD; Solow, BK; Stockl, KM; Zakharyan, A, 2011)
"Relationships between reproductive hormone levels, bone turnover marker levels, bone mineral density, and rates of bone loss were evaluated in premenopausal women with epilepsy taking enzyme-inducing antiepileptic drugs (EIAEDs: phenytoin or carbamazepine) or lamotrigine."3.77Normal vitamin D and low free estradiol levels in women on enzyme-inducing antiepileptic drugs. ( McMahon, DJ; Morrell, MJ; Pack, AM; Shane, E, 2011)
"Children aged 5 to 12 years with diagnosed epilepsy who received phenytoin monotherapy seen in the neurological clinic at Queen Sirikit National Institute of Child Health were studied."3.77Correlation between serum and salivary phenytoin concentrations in Thai epileptic children. ( Jaiweerawattana, U; Liamsuwan, S, 2011)
"Fosphenytoin was developed to eliminate the poor aqueous solubility and irritant properties of intravenous phenytoin."3.77New anticonvulsant drugs. Focus on flunarizine, fosphenytoin, midazolam and stiripentol. ( Bebin, M; Bleck, TP, 1994)
"The DNS II acetone fraction of Delphinium nordhagenii has exhibited the anticonvulsant actions by preventing the seizures against PTZ- and picrotoxin-induced seizure as well as 100% seizure protection in MES test."3.76Anticonvulsant activity of DNS II fraction in the acute seizure models. ( Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M, 2010)
"In this study of older adults with epilepsy, lamotrigine was the most effective AED as measured by 12-month retention and seizure freedom, with levetiracetam a close second."3.76Comparative effectiveness of 10 antiepileptic drugs in older adults with epilepsy. ( Arif, H; Bazil, CW; Buchsbaum, R; Hirsch, LJ; Pierro, J; Resor, SR; Sims, J; Whalen, M, 2010)
" The purpose of this study was to determine the allele and genotype frequencies of such genetic variants in patients with epilepsy from North India administered first-line antiepileptic drugs, such as phenobarbitone, phenytoin, carbamazepine and valproic acid, and compare them with worldwide epilepsy populations."3.76Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment. ( Baghel, R; Bala, K; Brahmachari, SK; Giddaluru, S; Gourie-Devi, M; Grover, S; Gupta, M; Kaur, H; Kaur, K; Kukreti, R; Narayanasamy, K; Sharma, A; Sharma, S; Talwar, P; Varma, B, 2010)
" She was receiving phenytoin for epilepsy for 2 years."3.76Phenytoin induced vitamin D deficiency presenting as proximal muscle weakness. ( Aggarwal, A; Faridi, MM, 2010)
" The influence of age and concomitant medications on the dose/concentration ratio of levetiracetam was examined in 103 children with epilepsy."3.76Age and comedications influence levetiracetam pharmacokinetics in children. ( Dahlin, MG; Ohman, I; Wide, K, 2010)
"Phenytoin, one of the most common antiepileptic drugs, is a major cause of antiepileptic drug hypersensitivity syndrome (AHS), which is a rare but potentially fatal complication."3.75Agranulocytosis following phenytoin-induced hypersensitivity syndrome. ( Imai, K; Ito, S; Oguni, H; Osawa, M; Sasaki, K; Shioda, M, 2009)
"Between 1999 and 2004, we enrolled pregnant women with epilepsy who were taking a single antiepileptic agent (carbamazepine, lamotrigine, phenytoin, or valproate) in a prospective, observational, multicenter study in the United States and the United Kingdom."3.75Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. ( Baker, GA; Browning, N; Clayton-Smith, J; Cohen, M; Combs-Cantrell, DT; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2009)
"To determine the utility and tolerability of levetiracetam (LEV) compared to phenytoin (PHT) in preventing clinical seizures in patients with subarachnoid hemorrhage (SAH)."3.75Utility of levetiracetam in patients with subarachnoid hemorrhage. ( Husain, AM; Shah, D, 2009)
"(1) Numerous follow-up studies of pregnancies in women with epilepsy show that valproic acid is more teratogenic than other antiepileptics."3.75Valproic acid: long-term effects on children exposed in utero. ( , 2009)
"Phenytoin has a wide range of pharmacologic effects other than its anticonvulsant activity."3.75Phenytoin revisited. ( Finkel, MJ, 1984)
"Phenytoin (PHT) is widely used to treat epilepsy in elderly patients, but information on its pharmacokinetics in this population is limited."3.74Phenytoin half-life and clearance during maintenance therapy in adults and elderly patients with epilepsy. ( Ahn, JE; Birnbaum, AK; Brundage, RC; Cloyd, JC; Conway, JM; Leppik, IE; Marino, SE; Musib, LC; Ramsay, RE; Rarick, JO; White, JR, 2008)
"Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) in Han Chinese, but not in Caucasian populations."3.74Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. ( Desudchit, T; Hirankarn, N; Kangwanshiratada, O; Korkij, W; Limotai, C; Locharernkul, C; Loplumlert, J; Shotelersuk, V; Suphapeetiporn, K; Tongkobpetch, S, 2008)
" Hyperhomocysteinemia was defined as fasting total Hcy above 12 micromol/L and/or post-methionine load concentrations above 38 micromol/L."3.74Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins. ( Apeland, T; Frøyland, ES; Kristensen, O; Mansoor, MA; Strandjord, RE, 2008)
"Both levetiracetam (LEV) and phenytoin (PHT) were associated with a low risk of early postoperative seizures and a moderate risk of later epilepsy."3.74Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery. ( Bromfield, EB; Hurwitz, S; Milligan, TA, 2008)
"The present work was undertaken to examine the central pharmacokinetics of phenytoin (PHT) in an experimental model of epilepsy, induced by administration of 3-mercaptopropionic acid (MP), and possible participation of P-glycoprotein in this model of epilepsy."3.74Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model. ( Auzmendi, J; Bramuglia, GF; Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Opezzo, JA; Taira, CA, 2007)
"Ecto-nucleotidases, one of the main mechanisms involved in the control of adenosine levels in the synaptic cleft, have shown increased activities after the pilocarpine model of epilepsy."3.74Antiepileptic drugs prevent changes induced by pilocarpine model of epilepsy in brain ecto-nucleotidases. ( Bogo, MR; Bonan, CD; Bruno, AN; Cognato, Gde P; da Silva, RS; Sarkis, JJ, 2007)
"A previous study conducted in Taiwan found a 100% association between HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine-tolerant subjects (odds ratio = 2,504)."3.74Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese. ( Baum, L; Cheng, AS; Kwan, P; Lau, KM; Man, CB; Ng, MH; Yu, E, 2007)
"Using the mouse maximal electroshock-induced seizure model, indicative of tonic-clonic seizures in humans, the present study was aimed at characterizing the interaction between remacemide and valproate, carbamazepine, phenytoin, and phenobarbital."3.74Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ; Malek, R; Patsalos, PN; Ratnaraj, N, 2007)
"Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been associated with some drugs, particularly anticonvulsants such as phenytoin."3.74[Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy]. ( Fernández, FA; Garcés, FJ; Pintor, E; Quesada, R, 2007)
"On the basis of epileptic model induced by pentylenetetrazol (PTZ), cognitive impairment model was induced by kindling epilepsy with PTZ everyday, which were then di-vided into the model-1 group, the CZD-1 group, the nimodipine-1 group, and those by injecting large dosage phenytoin sodium were divided into the model-2 group, the CZD-2 group and the nimodipine-2 group."3.74[Influence of repeated seizures and large dosage anti-epileptic drug on phosphorylated cAMP response element binding protein in rat's hippocampus and effect of Caoguo Zhimu Decoction]. ( He, J; Ma, SL, 2007)
"To compare the temporal pattern of seizures after acute withdrawal of oxcarbazepine (OXC) and phenytoin (PHT) in the epilepsy monitoring unit (EMU)."3.74Temporal pattern of oxcarbazepine and phenytoin withdrawal seizures during epilepsy monitoring. ( Abou-Khalil, BW; Azar, NJ; Song, Y; Wang, L, 2008)
" We previously reported biochemical evidence of increased bone turnover in premenopausal women with epilepsy on phenytoin monotherapy compared with those on carbamazepine, lamotrigine, and valproate."3.74Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy. ( McMahon, DJ; Morrell, MJ; Pack, AM; Randall, A; Shane, E, 2008)
"This is the first report demonstrating an association between the SCN1A polymorphism and carbamazepine-resistant epilepsy."3.74Association between SCN1A polymorphism and carbamazepine-resistant epilepsy. ( Abe, T; Hori, M; Ishitsu, T; Nakagawa, K; Nakagawa, T; Seo, T, 2008)
" We studied premenopausal women with epilepsy receiving antiepileptic drug monotherapy (phenytoin, carbamazepine, valproate, and lamotrigine)."3.73Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy. ( Doñe, S; Flaster, E; Holloway, L; Marcus, R; Morrell, MJ; Pack, AM; Randall, A; Seale, C; Shane, E, 2005)
"Across a range of assumptions used, the risk of hospitalization for Stevens-Johnson syndrome or toxic epidermal necrolysis in new users is low for carbamazepine, lamotrigine, phenytoin, phenobarbital, and valproic acid."3.73Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics. ( Messenheimer, J; Mockenhaupt, M; Schlingmann, J; Tennis, P, 2005)
"3 in a fetus exposed to phenytoin during pregnancy."3.73A fragile site at 10q23 (FRA10A) in a phenytoin-exposed fetus: a case report and review of the literature. ( Désilets, V; Duncan, AM; Morel, CF, 2005)
" In this study the anticonvulsant actions of norfluoxetine and fluoxetine were studied and compared to those of phenytoin and clonazepam in pentylenetetrazol-induced mouse epilepsy models."3.73Norfluoxetine and fluoxetine have similar anticonvulsant and Ca2+ channel blocking potencies. ( Harasztosi, C; Kecskeméti, V; Nánási, PP; Pál, B; Riba, P; Rusznák, Z; Szûcs, G; Wagner, R, 2005)
"We report a patient with epilepsy who presented with acute onset of left hemiparesis associated with phenytoin intoxication due to interaction with clobazam."3.73Benign angiopathy of the central nervous system associated with phenytoin intoxication. ( Kume, A; Nagao, H; Nakano, N; Wakamoto, H, 2006)
" The AEDs received by the mothers with epilepsy were Phenytoin, Carbamazepine, and Sodium valproate."3.73Physical growth and psychomotor development of infants exposed to antiepileptic drugs in utero. ( Arulmozhi, T; Dhanaraj, M; Rangaraj, R; Vengatesan, A, 2006)
"From 100 consecutive epilepsy patients we selected those with phenytoin use for more than 2 months and with MRI scan available for volumetric studies."3.72Cerebellar volume and long-term use of phenytoin. ( Cendes, F; De Marcos, FA; Ghizoni, E; Kobayashi, E; Li, LM, 2003)
" She had been diagnosed with idiopathic epilepsy and was given phenytoin 2 months before admission to our hospital."3.72Use of biperiden hydrochloride in a child with severe dyskinesia induced by phenytoin. ( Anlar, O; Caksen, H; Odabaş, D, 2003)
" The purpose of this study was to investigate the afferent fiber system to the cerebellum in patients with phenytoin (PHT)-induced cerebellar atrophy in comparison with cerebellar atrophy of other etiologies by using DT-MRI."3.72Diffusion tensor MRI and fiber tractography of cerebellar atrophy in phenytoin users. ( Chu, M; Heo, K; Kim, DI; Kim, DJ; Kim, SY; Lee, BI; Lee, SK; Mori, S, 2003)
"An infant who was exposed to phenytoin as monotherapy throughout pregnancy was born with the following abnormalities: midface hypoplasia, digit hypoplasia with syndactyly in the hands and feet, meningomyelocele, talipes equinovarus, and a long skin pedicle on the back."3.72Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism? ( Holmes, LB; Huang, T; Lyon, HM, 2003)
" Hence, the standard of care for older patients with epilepsy should be reevaluated, although the vast use of phenytoin in this population suggests that change in practice patterns may be difficult."3.72Potentially inappropriate antiepileptic drugs for elderly patients with epilepsy. ( Berlowitz, D; Charbonneau, A; Cramer, J; Kazis, L; Knoefel, J; Mandell, A; Pugh, MJ, 2004)
"A 19-year old man with cryptogenic simple partial and secondary generalized epilepsy developed blurred vision and xanthopsia after phenytoin loading for status epilepticus."3.72Acute visual dysfunction following phenytoin-induced toxicity. ( Deleu, D; Shenoy, R; Thakral, A, 2003)
" This clinical policy focuses on 6 critical questions: What laboratory tests are indicated in the otherwise healthy adult patient with a new-onset seizure who has returned to a baseline normal neurologic status?Which new-onset seizure patients who have returned to a normal baseline require a head computed tomography (CT) scan in the emergency department (ED)?Which new-onset seizure patients who have returned to normal baseline need to be admitted to the hospital and/or started on an antiepileptic drug?What are effective phenytoin or fosphenytoin dosing strategies for preventing seizure recurrence in patients who present to the ED after having had a seizure with a subtherapeutic serum phenytoin level?What agent(s) should be administered to a patient in status epilepticus who continues to seize after having received benzodiazepine and phenytoin?When should electroencephalographic (EEG) testing be performed in the ED? Recommendations for patient management are provided for each 1 of these topics on the basis of strength of evidence (Level A, B, or C)."3.72Clinical policy: Critical issues in the evaluation and management of adult patients presenting to the emergency department with seizures. ( , 2004)
"Phenytoin-induced gingival overgrowth is a well-known and frequently reported gingival lesion, which was first detected in 1939."3.72Phenytoin-induced gingival overgrowth in un-cooperated epilepsy patients. ( Cakmak, H; Gursoy, UK; Marakoglu, I; Marakoglu, K, 2004)
"The effects of phenytoin (PHT) and phenobarbital (PHB) on EEG activity and behavior was studied in the model of epilepsy induced by intracerebroventricular (i."3.72The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats. ( Stanojlovic, O; Stojanovic, J; Susic, V; Zivanovic, D, 2004)
"The nootropic drug piracetam was investigated in various experimental models of epilepsy."3.72Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models. ( De Sarro, G; Fischer, W; Kittner, H; Regenthal, R; Russo, E, 2004)
"To search for the optimal dosage of phenytoin in patients with epilepsy based on the metabolic activities of CYP2C9 and CYP2C19 polymorphisms, a total of 169 patients receiving phenytoin treatment for more than 1 month were recruited."3.72Dosage recommendation of phenytoin for patients with epilepsy with different CYP2C9/CYP2C19 polymorphisms. ( Chang, CJ; Chen, CC; Hung, CC; Lin, CJ; Liou, HH, 2004)
"To investigate the relationship between the genetic polymorphism of cytochrome CYP2C19 and CYP2C9 and the serum concentration of phenytoin (PHT) in patients with epilepsy."3.72[Association between genetic polymorphisms of CYP2C19 and CYP2C9 and phenytoin serum concentration]. ( Chen, B; Huang, Y; Qi, XL; Wang, WZ; Wang, YQ; Yang, JF, 2004)
" The boy was exposed to phenytoin, in combination with carbamazepine, during pregnancy."3.71Chondrodysplasia punctata (CDP) with features of the tibia-metacarpal type and maternal phenytoin treatment during pregnancy. ( Annerén, G; Brandberg, G; Larsson, M; Lönnerholm, T; Wester, U, 2002)
"We report the case of a 24-y-old woman who presented with repeated episodes of otitis due to panhypogammaglobulinemia and low levels of mature CD19 + B cells (84 cells/microl) associated with phenytoin treatment."3.71Reversible panhypogammaglobulinemia associated with phenytoin treatment. ( Pereira, LF; Sanchez, JF, 2002)
"To determine the effects of temperature on binding characteristics of phenytoin to serum proteins in paediatric patients with epilepsy."3.71Effect of temperature on serum protein binding characteristics of phenytoin in monotherapy paediatric patients with epilepsy. ( Itokazu, N; Kanemaru, R; Kodama, H; Kodama, Y; Shinozawa, S; Sugimoto, T, 2001)
"To evaluate the potential pharmacokinetic interactions between topiramate (TPM) and phenytoin (PHT) in patients with epilepsy by studying their pharmacokinetics (PK) after monotherapy and concomitant TPM/PHT treatment."3.71Topiramate and phenytoin pharmacokinetics during repetitive monotherapy and combination therapy to epileptic patients. ( Bialer, M; Bishop, FE; Curtin, CR; Doose, DR; Gisclon, LG; Kunze, KL; Levy, RH; Mather, GG; Roskos, LK; Sachdeo, RC; Sachdeo, SK; Shen, DD; Streeter, AJ; Thummel, KE; Trager, WF, 2002)
"To elucidate the involvement of bFGF (basic fibroblast growth factor) in the pathogenesis of phenytoin-induced gingival overgrowth, we measured the concentration of bFGF in the serum of 36 epileptic patients taking phenytoin and in 94 normal volunteers by enzyme-linked immunosorbent assay technique."3.70Increased bFGF level in the serum of patients with phenytoin-induced gingival overgrowth. ( Maita, E; Sasaki, T, 1998)
"To evaluate the interictal autonomic nervous system function in 84 patients with epilepsy: 37 with newly diagnosed, previously untreated epilepsy, and 47 patients receiving long-term carbamazepine (CBZ), phenytoin (PHT), or valproate (VPA) monotherapy, or CBZ plus PHT, or CBZ plus VPA for their seizure disorder."3.70Interictal cardiovascular autonomic responses in patients with epilepsy. ( Ansakorpi, H; Isojärvi, JI; Myllylä, VV; Repo, M; Suominen, K; Tolonen, U, 1998)
"One hundred and ninety-five (113 black and 82 coloured) compliant people with epilepsy receiving generic phenytoin monotherapy."3.70Benefits of a clinical pharmacokinetic service in optimising phenytoin use in the western Cape. ( Folb, PI; Kies, BM; Seymour, MA; Valodia, P, 1998)
"The last premortem serum concentrations of phenobarbital (PB), phenytoin (PHT), carbamazepine (CBZ) and its CBZ-10,11-epoxide metabolite (CE) were compared with the corresponding postmortem serum concentrations in 16 adult patients of an epilepsy centre."3.70Comparison between premortem and postmortem serum concentrations of phenobarbital, phenytoin, carbamazepine and its 10,11-epoxide metabolite in institutionalized patients with epilepsy. ( Jürgens, U; May, T; Rambeck, B; Schnabel, R, 1999)
"A 30-year-old man was given high doses of phenytoin together with 4 antituberculous drugs for a seizure associated with a probable brain tuberculoma."3.70[Residual cerebellar ataxia following acute phenytoin intoxication]. ( al Beladi, K; al Jumah, M; Amene, P; Awada, A, 1999)
"The effects of temperature on the binding kinetics of phenytoin (PHT) to serum proteins were determined in patients with epilepsy."3.70Temperature effect on serum protein binding kinetics of phenytoin in monotherapy patients with epilepsy. ( Kanemaru, R; Kodama, H; Kodama, Y; Mitsuyama, Y; Shinozawa, S; Todaka, K, 1999)
" We report a patient with familial hypercholesterolaemia and epilepsy in whom the introduction and subsequent discontinuation of phenytoin were associated with marked changes in the lipid response to treatment with simvastatin and atorvastatin."3.70Efficacy of statin therapy: possible effect of phenytoin. ( Dominiczak, MH; Murphy, MJ, 1999)
"The potential effect of co-medication with phenobarbitone, primidone and carbamazepine on plasma and saliva concentrations of 5-(4-hydroxyphenyl)-5-phenylhydantoin (4-HPPH), the major metabolite of phenytoin in man and on the incidence of phenytoin-induced gingival overgrowth was investigated in a group of 36 adult epileptic patients."3.70The effect of multiple anticonvulsant therapy on the expression of phenytoin-induced gingival overgrowth. ( Ball, DE; Kamali, F; McLaughlin, WS; Seymour, RA, 1999)
" In PHT nonresponders, TPM significantly increased ADT, which is in line with its proven efficacy in patients with refractory partial epilepsy in whom phenytoin has failed."3.70Anticonvulsant efficacy of topiramate in phenytoin-resistant kindled rats. ( Ebert, U; Löscher, W; Reissmüller, E, 2000)
"Our data indicate that not only fasting but also 6h-PML tHcy levels should be determined in order to identify hyperhomocysteinemia among patients on AEDs."3.70Homocysteine concentrations and methionine loading in patients on antiepileptic drugs. ( Apeland, T; Kristensen, O; Mansoor, MA; Strandjord, RE, 2000)
"The chronic treatment with phenytoin or the acute intoxication by this drug may cause permanent cerebellar injury with atrophy of cerebellum vermis and hemispheres, which can be detected by neuroimaging studies."3.70[Dose-dependent relationship of chronic use of phenytoin and cerebellar atrophy in patients with epilepsy]. ( Cendes, F; Dantas, CD; Del Negro, A; Montenegro, MA; Zanardi, V, 2000)
"The aim of the present study was to determine the gender-related binding characteristics of phenytoin (PHT) to serum proteins in adult patients with epilepsy."3.70No gender effect on binding characteristics of phenytoin to serum proteins in monotherapy for adult patients with epilepsy. ( Kanemaru, R; Kodama, H; Kodama, Y; Mitsuyama, Y; Shinozawa, S; Todaka, K, 2000)
"We evaluated the effects of carbamazepine (CBZ) on serum androgen levels and sexual function prospectively for 5 years in 11 men with epilepsy and in 25 patients receiving either CBZ (14 patients) or phenytoin (PHT) (11) monotherapy for > 5 years."3.69Carbamazepine, phenytoin, sex hormones, and sexual function in men with epilepsy. ( Isojärvi, JI; Lukkarinen, O; Myllylä, VV; Pakarinen, AJ; Repo, M, 1995)
"Urinary excretions of carbamazepine, carbamazepine-10,11-epoxide, carbamazepine-10,11-trans-diol, 9-hydroxyacridan and 2- and 3-hydroxycarbamazepine were measured at various stages of pregnancy, and in the post-natal period, in ten epileptic women, six of whom took no other enzyme-inducing anticonvulsant and four of whom took such co-medication."3.69Metabolism of carbamazepine and co-administered anticonvulsants during pregnancy. ( Bernus, I; Dickinson, RG; Eadie, MJ; Hooper, WD, 1995)
"Cerebellar atrophy has been noted in patients with phenytoin exposure."3.69Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy. ( Barr, WB; Lantos, G; Ney, GC; Schaul, N, 1994)
"Phenytoin serum concentrations were evaluated in 88 epileptic women at different stages of pregnancy and 40 women during postnatal periods."3.69Phenytoin serum concentration monitoring during pregnancy and puerperium in Mexican epileptic women. ( Amancio-Chassin, O; Belmont-Gómez, A; Estrada-Altamirano, A; Hernández-Serrano, M; Herrerías-Cunedo, T; Rodríguez-Palomares, C, 1995)
"To evaluate the population pharmacokinetics of valproic acid in children, 97 steady-state serum valproate concentration measurements were gathered during normal, routine, outpatient care of 52 children with epilepsy (1."3.69A model for estimating individualized valproate clearance values in children. ( Botha, JH; Gray, AL; Miller, R, 1995)
" We studied the pharmacokinetic and pharmacodynamic aspects of an oral 15-mg dose of midazolam in 6 patients with epilepsy who are also taking carbamazepine (CBZ) or phenytoin (PHT)."3.69Concentrations and effects of oral midazolam are greatly reduced in patients treated with carbamazepine or phenytoin. ( Backman, JT; Laaksovirta, H; Neuvonen, PJ; Ojala, M; Olkkola, KT, 1996)
"Topiramate, a structurally novel anticonvulsant, and phenytoin were evaluated in a rat model of ischemia-induced epilepsy."3.69Anticonvulsant activity of topiramate and phenytoin in a rat model of ischemia-induced epilepsy. ( Edmonds, HL; Jiang, YD; Shank, RP; Zhang, PY, 1996)
"The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36."3.69Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996)
"The cobalt model of epilepsy, in combination with the C-14 2-deoxyglucose (2-DG) autoradiographic technique, was used to assess the effects of phenytoin (PHT) and ethosuximide (ESM), two antiepileptic drugs, and ketamine (KET), a drug with anticonvulsant properties, on brain activity."3.69A combined cobalt and C-14 2-deoxyglucose approach to antiepileptic drug assessment. ( Cooper, RM; Krenz, NR, 1996)
"We examined the effect of CYP2C9/19 polymorphisms on the pharmacokinetics of phenytoin in 17 Japanese patients with epilepsy."3.69Effect of CYP2C polymorphisms on the pharmacokinetics of phenytoin in Japanese patients with epilepsy. ( Furusho, K; Hashimoto, Y; Hattori, H; Iui, K; Odani, A; Otsuki, Y; Takano, M, 1996)
" Available history is that he is a 20-year-old student with well-controlled epilepsy for which he takes phenytoin."3.69Drugs and brain death. ( Chivell, W; Fearnside, M; Kennedy, MC; Moran, JL; Morris, RG; Tobin, B; Upton, RN, 1996)
"We report the first case of Epstein Barr virus (EBV) positive non-Hodgkin's lymphoma occurring 20 years after continuous phenytoin therapy for idiopathic epilepsy."3.69EBV-positive non-Hodgkin's lymphoma developing after phenytoin therapy. ( Del Campo, F; Dominguez-Franjo, P; Garcia-Suarez, J; Herrero, B; Munoz, MA; Pardo, A; Piris, MA, 1996)
"Twelve patients with epilepsy receiving chronic phenytoin therapy and 12 healthy control subjects matched for age and gender received a single oral dose of nisoldipine (40 and 20 mg, respectively)."3.69Reduced plasma nisoldipine concentrations in phenytoin-treated patients with epilepsy. ( Cipolla, G; Gatti, G; Heinig, R; Michelucci, R; Ochan, M; Passarelli, D; Perucca, E; Tassinari, CA, 1996)
"We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures."3.69Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1997)
" Eighty patients presenting with epilepsy received monotherapies of valproic acid, phenytoin, or carbamazepine; 18 patients did not receive antiepileptic drug therapy."3.69Color vision tests for early detection of antiepileptic drug toxicity. ( Bayer, AU; Dichgans, J; Kuehn, M; Paulus, W; Ried, S; Schmidt, D; Thiel, HJ; Zrenner, E, 1997)
"We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy."3.69BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. ( Morimoto, K; Sato, H; Sato, K; Sato, S; Yamada, N, 1997)
" We studied the changes in arrhythmia profile and heart-rate variability, during abrupt withdrawal of carbamazepine and phenytoin treatment in 10 patients with side effects on these drugs."3.69Changes in arrhythmia profile and heart rate variability during abrupt withdrawal of antiepileptic drugs. Implications for sudden death. ( Bergfeldt, L; Ericson, M; Kennebäck, G; Tomson, T, 1997)
"The possibility that vigabatrin (VGB) decreases serum phenytoin (PHT) concentration by lowering the oral bioavailability of PHT was investigated in 21 patients with epilepsy."3.68Vigabatrin-induced decrease in serum phenytoin concentration does not involve a change in phenytoin bioavailability. ( Bartoli, A; Gatti, G; Marchiselli, R; Michelucci, R; Perucca, E; Pisani, F; Richens, A; Tassinari, CA; Timmings, P; Zaccara, G, 1993)
"Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline."3.68Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993)
"The anticonvulsant activity of U-54494A was studied in a 4-aminopyridine (4-AP) epilepsy model using extracellular recordings in in vitro hippocampal slices."3.68U-54494A reduces 4-AP-induced afterdischarges of CA1 pyramidal cells in the hippocampal slice of the rat. ( Camacho-Ochoa, M; Hoffmann, WE; Piercey, MP; VonVoigtlander, PF, 1992)
"This investigation examines the incidence of phenytoin-induced gingival overgrowth in a population of epileptic patients who attend General Medical Practices for treatment of their epilepsy and compares the gingival changes with an otherwise healthy group of patients."3.68Incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients in general medical practice. ( Rawlins, MD; Seymour, RA; Thomason, JM, 1992)
"The steady-state 72 h urinary excretion of various phenytoin metabolites has been measured in 10 epileptic women, whose plasma phenytoin concentrations relative to the phenytoin dose fell during pregnancy and rose again post-partum."3.68Phenytoin metabolism during pregnancy. ( Dickinson, RG; Eadie, MJ; Hooper, WD; Lander, CM; McKinnon, GE, 1992)
"We retrospectively collected plasma level assessments performed in 96 adult patients with epilepsy on stable monotherapy, including 9 patients on clobazam (CLB), 34 on carbamazepine (CBZ), 24 on phenobarbital (PB), 9 on phenytoin (PHT), and 20 on valproate (VPA); these results were compared to those obtained in 54 adult patients on stable bitherapy with the association of CLB with either CBZ (n = 17), PB (n = 17), PHT (n = 5), or VPA (n = 15)."3.68Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy. ( Bonneton, J; Dravet, C; Genton, P; Mesdjian, E; Roger, J; Sennoune, S, 1992)
"A single case of IgA nephropathy with a concomitant tubulointerstitial nephritis, developing during a long-term phenytoin therapy is reported."3.68[Long-term phenytoin (Diphedan) therapy leading to IgA nephropathy]. ( Deák, G; Háber, A; Nagy, J; Süle, T, 1992)
"We report the case of a young man suffering from epilepsy who developed chronic calcified pancreatitis after ten years of therapy with the anticonvulsant drugs carbamazepine and phenytoin."3.68Anticonvulsant-induced chronic pancreatitis. A case report. ( Billi, P; Broccoli, PL; Fontana, G; Melandri, R; Pezzilli, R, 1992)
" We report here the occurrence of crusted scabies in a 40-year-old man with acquired selective IgA deficiency suspected to be caused by long-term medication with phenytoin for epilepsy."3.68Crusted scabies in acquired selective IgA deficiency. ( Hamada, T; Kitajima, J; Kono, T; Shindo, K, 1991)
"We report the cases of four patients who were taking the anticonvulsant drugs phenytoin or carbamazepine and in whom skin lesions developed that showed histologic features suggestive of mycosis fungoides."3.68Mycosis fungoides-like lesions associated with phenytoin and carbamazepine therapy. ( Kruyswijk, MR; Meijer, CJ; Rijlaarsdam, U; Scheffer, E; Willemze, R, 1991)
"In newly diagnosed adult patients with epilepsy followed prospectively on monotherapy, carbamazepine and phenytoin were associated with a fall in plasma uric acid, but sodium valproate and phenobarbitone were associated with a rise in plasma uric acid."3.68Plasma uric acid in patients receiving anticonvulsant monotherapy. ( Heller, AJ; Johnson, AL; Marshall, WJ; Reynolds, EH; Ring, HA, 1991)
"The effects of antiepileptic drugs (AED) on infants during pregnancy and delivery were studied in a total of 82 epileptic mothers on various monotherapies; 29 cases receiving valproic acid (VPA), 20 receiving phenytoin (PHT), 18 on carbamazepine (CBZ) and 15 on phenobarbital (PB)."3.68[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital]. ( Ishikawa, S; Izumi, M; Okada, H; Takeda, A; Tanaka, H, 1991)
"Methsuximide was added to the therapeutic regimens of 25 children with intractable epilepsy."3.68Methsuximide for intractable childhood seizures. ( Greenwood, RS; Miles, MV; Tennison, MB, 1991)
"The case of a mentally handicapped female patient is presented who developed typical pellagra with dermatitis, diarrhoea and mental alteration following a long-term antiepileptic treatment with phenytoin, ethosuximide and valproic acid."3.68[Pellagra in anticonvulsive therapy]. ( Bartels, H; Hebestreit, H; Mingers, AM; Pannenbecker, J, 1990)
" This is a syndrome of idiopathic generalized epilepsy that responds to treatment with valproic acid."3.68Eyelid twitching seizures and generalized tonic-clonic convulsions: a syndrome of idiopathic generalized epilepsy. ( Ferrendelli, JA; Miller, JW, 1990)
"Free and total carbamazepine (CBZ) and carbamazepine-epoxide (CBZ-EP) plasma levels were obtained on 113 patients with epilepsy (18-61 years old) controlled on either monotherapy or coadministration with either phenobarbital (PB), phenytoin (PHT), valproic acid (VPA), or all three."3.68Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy. ( Briggle, TV; Guterman, A; McManus, DQ; Perchalski, R; Ramsay, RE; Vazquez, D; Wong, P; Yost, RA, 1990)
"39 adult patients with intractable epilepsy were successfully treated with high-dose monotherapy, using carbamazepine or phenytoin."3.68[High-dose monotherapy in intractable epilepsy]. ( Peng, SM; Wu, JZ, 1990)
"An infant with dysmorphic features was born to an epileptic mother who had taken phenytoin and sodium valproate throughout pregnancy."3.68Neocerebellar hypoplasia in a neonate following intra-uterine exposure to anticonvulsants. ( Hope, PL; Lindenbaum, RH; Squier, W, 1990)
"A man developed acne keloidalis-like lesions in the scalp during treatment with diphenylhydantoin and carbamazepine for epilepsy."3.68Acne keloidalis-like lesions on the scalp associated with antiepileptic drugs. ( Ben-Dor, D; Grunwald, MH; Halevy, S; Livni, E, 1990)
" Fifty-two children had been exposed to phenytoin monotherapy, 19 to carbamazepine monotherapy, 27 to drug combinations including barbiturates, 29 to other drug combinations, and 17 children had not been exposed to antiepileptic drugs (AEDs) during pregnancy."3.68Head circumference in children of epileptic mothers: contributions of drug exposure and genetic background. ( Bardy, AH; Gaily, EK; Granström, ML; Hiilesmaa, VK, 1990)
"Serum concentrations of the main vitamin D metabolites and of calcium, phosphate, and alkaline phosphatase were determined in each of the three trimesters of pregnancy and in simultaneously obtained maternal and cord blood at delivery in 22 epileptic women treated with diphenylhydantoin or carbamazepine alone or with a combination with one other drug."3.67Anticonvulsant drug therapy in human pregnancy: effects on serum concentrations of vitamin D metabolites in maternal and cord blood. ( Aarskog, D; Aksnes, L; Markestad, T; Strandjord, RE; Ulstein, M, 1984)
"To evaluate the effect of anticonvulsants on serum levels of free thyroxine (FT4) and thyroxine-binding globulin (TBG), 32 patients with epilepsy receiving long-term anticonvulsant treatment (mean duration 81."3.67Lowering effect of diphenylhydantoin on serum free thyroxine and thyroxine binding globulin (TBG). ( Hiraiwa, M; Miyasaka, M; Mori, K; Shimoda, S; Suzuki, H; Suzuki, Y; Yamazaki, N, 1984)
"Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug."3.67Bioavailability and pharmacokinetics of phenytoin during pregnancy. ( Chalk, JB; de Wytt, C; Eadie, MJ; Lander, CM; Livingstone, I; Smith, MT; Symoniw, P, 1984)
"We evaluated the therapeutic efficacy and toxicity of high-dose monotherapy, using carbamazepine or phenytoin, in patients with previously uncontrolled seizures."3.67High-dose monotherapy in treatment of intractable seizures. ( Dinner, DS; Lesser, RP; Lüders, H; Pippenger, CE, 1984)
"Chromosome studies were carried out on the peripheral blood of 26 epilepsy patients treated with phenobarbital and/or diphenylhydantoin, on ten healthy controls and on eight untreated epileptic controls."3.67Chromosomal studies of peripheral blood from epileptic patients treated with phenobarbital and/or diphenylhydantoin. ( Ambani, LM; Kulkarni, PS; Mondkar, VP; Sonawalla, AB, 1984)
"In a cross-sectional, epidemiological study of phenytoin induced gingival overgrowth in 77 institutionalized persons with epilepsy, the severity of the gum lesions was quantified by means of a precise new technique."3.67Phenytoin induced gingival overgrowth in institutionalized epileptics. ( Best, H; Hassell, T; Murphy, T; O'Donnell, J; Pearlman, J; Tesini, D, 1984)
"A patient with epilepsy and psoriasis in phenytoin therapy was treated with PUVA with no effect at all."3.67Interaction between 8-methoxypsoralen and phenytoin. Consequence for PUVA therapy. ( Hueg, B; Staberg, B, 1985)
"The peripheral blood lymphocytes, serum immunoglobulins, C3 and C4 complement protein concentrations of 20 patients with idiopathic epilepsy who were receiving phenytoin were examined and compared with 30 healthy controls in order to obtain a detailed profile of the effects of the drug on the humoral and cellular immune systems."3.67Serum immunoglobulins, complement levels and lymphocyte subpopulations in phenytoin-treated epileptic patients. ( Başaran, N; Hincal, F; Kansu, E, 1989)
"The estimation of Michaelis-Menten pharmacokinetic parameters in patients with epilepsy receiving phenytoin continues to be a vexing problem."3.67Determination of enzyme or binding constants using generalized linear models, with particular reference to Michaelis-Menten models. ( Friel, P; Guo, SW; Leurgans, S; van Belle, G; Yerby, M, 1989)
" Statistical analyses showed that group 2 had a longer history of epilepsy with a consequently longer duration of phenytoin (PHT) consumption."3.67Role of the cerebellum in complex human behavior. ( Attig, E; Botez, MI; Botez, T; Elie, R, 1989)
"We have identified ten children who developed gastritis after prolonged anticonvulsant therapy that included either valproic acid or divalproex sodium."3.67Gastritis with valproate therapy. ( Bobele, GB; Bodensteiner, JB; Grunow, JE; Hille, MR; Marks, WA; Morris, MP; Tuggle, D, 1988)
"A 26-year-old woman, treated with phenytoin for 10 years because of epilepsy, had Norplant subdermal implants inserted after a legal abortion."3.67Enhanced metabolism of levonorgestrel during phenytoin treatment in a woman with Norplant implants. ( Odlind, V; Olsson, SE, 1986)
"To assess the most efficient means of monitoring thyroid status in an epilepsy clinic, total thyroxine (T4), free thyroxine stimulating hormone (TSH) were measured in 71 adult patients treated long-term with either phenytoin (DPH), carbamazepine (CBZ) or sodium valproate (VAL)."3.67The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic. ( Borsey, DQ; Browning, MC; Connacher, AA; Davidson, DL; Jung, RT, 1987)
"In a survey of the red cell folate status of 200 patients with epilepsy, compared to 72 controls, we found that median red cell folate levels were reduced significantly in patients treated with phenytoin (p less than 0."3.67A comparative study of the relative effects of anticonvulsant drugs and dietary folate on the red cell folate status of patients with epilepsy. ( Baker, M; Bissessar, A; Callaghan, N; Crowley, M; Goggin, T; Gough, H, 1987)
"The Comprehensive Epilepsy Program of Minnesota database was searched for patients who had no dose change of carbamazepine (CBZ), phenytoin (PHT) or valproate (VPA) for 3 consecutive visits."3.67Variability of phenytoin, carbamazepine and valproate concentrations in a clinic population. ( Leppik, IE, 1988)
"The need for careful monitoring of plasma concentrations of phenytoin during use of the drug in the treatment of epilepsy is well recognized; there can be great intersubject variation in the absorption rate and clearance rate of the drug, and its therapeutic ratio is narrow."3.67Comparative determination of phenytoin in plasma by fluorescence polarization immunoassay and high performance liquid chromatography. ( al-Turk, WA; Awidi, AS; Daradkeh, TK; Othman, S; Shaheen, O, 1987)
" Of the study group, 106 children had been exposed to antiepileptic drugs (82 to phenytoin) during pregnancy; 44 (36%) mothers had had generalized convulsions during pregnancy."3.67Minor anomalies in offspring of epileptic mothers. ( Bardy, A; Gaily, E; Granström, ML; Hiilesmaa, V, 1988)
"In the routine care of 37 patients at the epilepsy outpatient clinic of Baragwanath Hospital, Johannesburg, 100 steady-state serum phenytoin concentrations were measured."3.67Population pharmacokinetics of phenytoin in South African black patients. ( Klein, C; Miller, R; Rheeders, M; Suchet, I, 1987)
"We report the occurrence of bilateral cataracts in a young adult which developed shortly after documented high serum levels of phenytoin."3.67Development of presenile cataracts in association with high serum levels of phenytoin. ( Earll, J; Kattan, H; Lemp, M; Mathers, W, 1987)
" Their psychiatric interest stems from evidence of an inhibiting effect of certain substances, such as carbamazepine or phenytoin, which are effective in the treatment of both epilepsy and mental disorders, but this effect is also found for lithium (Post et al."3.67Kindling models and antikindling effects of mood normalizers. ( Azorin, JM; Tramoni, V, 1987)
"Report on a prospective longitudinal study of alterations in polygraphic sleep by phenytoin monotherapy for epilepsy."3.67Response of polygraphic sleep to phenytoin treatment for epilepsy. A longitudinal study of immediate, short- and long-term effects. ( Noachtar, S; Röder-Wanner, UU; Wolf, P, 1987)
"The incidence of grand mal seizures, distribution of drug levels relative to the therapeutic range and the incidence of side effects were monitored before and after the provision of same-day preconsultation assay results (phenytoin and carbamazepine) to an epilepsy clinic."3.67Availability of drug assay results and dosage advice improves antiepileptic care in a specialist neurology outpatient clinic. ( Gilligan, BS; Harrison, PM; Heinzow, U; Horne, M; Ioannides-Demos, LL; McLean, AJ; Tong, N; Wodak, J, 1985)
"After treatment with valproic acid a 19-year-old female patient with Friedreich's ataxia and generalised epilepsy died following acute hepatic failure with massive lactacidosis."3.67[Acute liver necrosis caused by valproate]. ( Hackenberg, K; Rengeling, M; Rühl, G; Zäh, W, 1985)
"Steady-state serum concentrations of phenytoin and phenobarbital were obtained in 70 epileptic patients in Taiwan and evaluated with respect to age, sex, and body weight."3.67Steady-state serum levels of anticonvulsant drugs in Chinese epileptic patients living in Taiwan. ( Lai, ML, 1985)
"Reversible chronic cerebellar ataxia followed phenytoin treatment in two epileptic women."3.67Reversible chronic cerebellar ataxia after phenytoin intoxication: possible role of cerebellum in cognitive thought. ( Attig, E; Botez, MI; Gravel, J; Vézina, JL, 1985)
"Among 50 patients with phenytoin intoxication, 14 had seizures during the episode."3.67Incidence of seizures with phenytoin toxicity. ( Masdeu, JC; Stilman, N, 1985)
"Phenytoin has been shown to induce serum IgA deficiency in patients with epilepsy."3.66The reversibility of phenytoin-induced IgA deficiency. ( Aarli, JA; Gilhus, NE, 1981)
"A total of 20 children with various types of epilepsy were treated with valproate, 11 with monotherapy and 9 with valproate in combination with phenobarbitone, phenytoin, or carbamazepine."3.66Plasma concentrations of valproate during maintenance therapy in epileptic children. ( Boréus, LO; Lundberg, B; Nergårdh, A, 1982)
"The effects of delta 9-tetrahydrocannabinol (delta 9-THC), two of its metabolites, 8 beta-hydroxy-delta 9-THC and 11-hydroxy-delta 9-THC, and cannabidiol were comparatively studied by means of an iron-induced cortical focal epilepsy in conscious rats with chronically implanted electrodes."3.66Central excitatory properties of delta 9-tetrahydrocannabinol and its metabolites in iron-induced epileptic rats. ( Karler, R; Turkanis, SA, 1982)
"Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered."3.66Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports. ( Arena, R; Bindi, A; Bonuccelli, U; De Scisciolo, G; Marcacci, G; Rossi, L, 1983)
"The problem of phenytoin-induced gingival hyperplasia is dicussed within the context of consultative planning between oral care practitioners and the physician managing the epilepsy."3.66Therapeutic alternatives in phenytoin-induced gingival hyperplasia. A case report and discussion. ( Kirkham, DB; Reynolds, NC, 1980)
"Sodium valproate is often used with phenytoin when epilepsy cannot be controlled by a single drug."3.66Phenytoin-valproate interaction: importance of saliva monitoring in epilepsy. ( Hamshaw-Thomas, A; Knott, C; Reynolds, F, 1982)
"In 12 institutionalized epilepsy patients who had been treated 19 months (SD +/- 5) with valproic acid, 27."3.66Serial free and plasma valproic acid and phenytoin monitoring and drug interactions. ( Haidukewych, D; Rodin, EA, 1981)
"The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)."3.66Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982)
"Clinical and experimental studies were performed on the mechanisms of metabolic acidosis observed in the children with epilepsy who had long been treated with anticonvulsants such as phenobarbital (PB) or diphenylhydantoin (DPH)."3.66[Studies on the mechanism of metabolic acidosis observed in the children treated with anticonvulsants]. ( Nagai, B, 1982)
"Cataracts developed in two young adults who were receiving prolonged antiepileptic treatment with phenobarbital sodium and phenytoin sodium."3.66Presenile cataracts in phenytoin-treated epileptic patients. ( Bar, S; Feller, N; Savir, H, 1983)
" In severely jaundiced patients (serum bilirubin concentrations greater than 140 mumol/l) a markedly decreased or absent uptake of 99mTc-EHIDA was observed."3.66The influence of bilirubin, alcohol and certain drugs on the kinetics of 99mTc-Diethyl IDA (EHIDA) in humans. ( Coenegracht, JM; Oei, TL; van Breda Vriesman, PJ, 1983)
"Analysis of plasma phenytoin in a group of patients treated for epilepsy showed that only 36% had values in the therapeutic range."3.66Prediction of phenytoin dosage in epilepsy using multiple linear regression. ( Gray, SP, 1982)
"The effect of phenytoin (PHT) on the metabolism of zinc (Zn) and copper (Cu) has been studied during treatment for epilepsy."3.66Zinc and copper metabolism in phenytoin therapy. ( Hallmans, G; Palm, R, 1982)
" Using accepted CT criteria for the diagnosis of cerebellar atrophy, the films were analyzed in a blind, unbiased fashion to evaluate possible relationship between cerebellar atrophy and phenytoin use or epilepsy itself."3.66Cerebellar atrophy in epilepsy and headache: lack of relationship to phenytoin. ( Ballenger, CE; Brooks, BS; El Gammal, T; Green, JB; King, DW; Lucke, JF, 1982)
"A 5-year-old child with epilepsy and underlying brain damage developed choreo-athetosis during intoxication with phenytoin."3.66Choreo-athetosis induced by phenytoin in an epileptic child. A case report. ( Sandyk, R, 1981)
"The folic acid absorption test (FAAT) has carried out in 18 normal control subjects; 8 patients with proven atrophy of the jejunal mucosa; 7 patients with gastric ulcus; 17 patients with reactive hypoglycemia; 13 patients with diabetes mellitus, and, finally, 9 epileptic patients treated with diphenylhydantoin (DPH)."3.66Folic acid absorption test in various clinical conditions. ( Bachevalier, J; Botez, MI, 1981)
"1 Patients with poorly controlled epilepsy were cautiously transferred from multiple drug therapy to treatment with phenytoin sodium alone."3.66Serum phenytoin concentration and clinical response in patients with epilepsy. ( Gannaway, DJ; Mawer, GE, 1981)
"We describe a procedure for determining 2-ethyl-2-phenylmalonamide (I) in serum of epilepsy patients dosed with primidone (II) for seizure control, by extracting the sample with chloroform under basic conditions, with use of an internal standard, 2-ethyl-2-(p-tolyl)malonamide, and without derivative formation."3.66Monitoring 2-ethyl-2-phenylmalonamide in serum by gas-liquid chromatography: application to retrospective study in epilepsy patients dosed with primidone. ( Haidukewych, D; Rodin, EA, 1980)
"Nine cases of childhood epilepsy manifesting motor convulsions uncontrolled despite high levels of phenytoin (PHT) were studied clinically and electroencephalographically."3.66Childhood epilepsy uncontrolled by phenytoin: clinical and electroencephalographic study. ( Iinuma, K; Onuma, A; Tada, K; Takamatsu, N, 1979)
"Gingival hyperplasia caused by phenytoin sodium is rarely encountered in edentulous persons."3.66Diphenylhydantoinate-induced hyperplasia of the masticatory mucosa in an edentulous epileptic patient. ( Dreyer, WP; Thomas, CJ, 1978)
"Blood levels of phenytoin, total thyroxine, and free thyroxine were determined in 10 epileptic women during and following pregnancy."3.66Epilepsy and pregnancy. Serum thyroxine levels during phenytoin therapy. ( Ramsay, RE; Spellacy, WN; Strauss, RG; Wilder, BJ; Willmore, LJ, 1979)
" The treatment of status epilepticus with intravenous phenytoin is effective."3.66Epilepsy and pregnancy. ( Bruni, J; Willmore, LJ, 1979)
"The effect of long-term phenytoin therapy on serum triglyceride and cholesterol levels in 20 patients with epilepsy was investigated."3.66Changes in serum triglyceride and cholesterol levels during long-term phenytoin treatment for epilepsy. ( Luoma, PV; Reunanen, MI; Sotaniemi, EA, 1979)
" Antipyrine t1/2 did not distinguish epileptics with osteomalacia from other epileptic patients and half-lives were similar in patients treated with phenytoin and a barbiturate to those in patients on phenytoin alone."3.66Antiopyrine half-life as a measure of hepatic enzyme induction: clinical applications in a chronic epileptic population. ( Byrne, E; Frewin, DB; Hallpike, JF; Harman, AW, 1979)
"Birth defects associated with phenytoin and phenobarbital taken during pregnancy include craniofacial and limb deformities."3.66Fetal hydantoin syndrome in triplets. A unique experiment of nature. ( Bustamante, SA; Stumpff, LC, 1978)
", raise the possibility that fetal damage previously attributed to phenytoin and other anticonvulsant drugs, principally phenobarbitone, may be due to epilepsy itself."3.65Anticonvulsants and parental epilepsy in the development of birth defects. ( Hartz, SC; Heinonen, OP; Mitchell, AA; Monson, RR; Rosenberg, L; Shapiro, S; Siskind, V; Slone, D, 1976)
"The therapeutics results with the use of different drugs (diazepam, nitrazepam, clonazepam, diphenylhydantoin, barbiturates--phenobarbital and primidone--, sodium dipropylacetate and ACTH) in twenty-nine patients with Lennox--Gastaut syndrome are carefully analysed."3.65[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome]. ( Lison, MP; Speciali, GG, 1977)
"Plasma anticonvulsant levels were followed during pregnancy in 11 epileptic women taking phenytoin and/or phenobarbital or a drug metabolized in the body to phenobarbital."3.65Plasma anticonvulsant concentrations during pregnancy. ( Eadie, MJ; Edwards, VE; Lander, CM; Tyrer, JH, 1977)
"Malignant mesenchymoma developed in an 18-year-old patient with phenytoin-associated cleft lip and palate."3.65Malignant mesenchymoma and birth defects. Prenatal exposure to phenytoin. ( Blattner, WA; Fraumeni, JF; Henson, DE; Young, RC, 1977)
"A 49-year-old female with chronic alcoholism and epilepsy, treated with phenytoin, began to convulse when treatment with disulfiram (an inhibitor of phenytoin metabolism) was discontinued."3.65Multiple drug interactions with phenytoin. ( Birkett, DJ; Chinwah, PM; Graham, GG; Hickie, JB; Wade, DN, 1977)
" In the Hungarian Congenital Malformation Register use of the anticonvulsants diazepam and phenobarbiturates during pregnancy was determined in infants delivered with cleft lip with or without cleft palate, posterior cleft palate and, as a control, anencephaly and spina bifida."3.65A teratological evaluation of anticonvulsant drugs. ( Czeizel, E; Lakos, P, 1977)
"The effect of toxic and non-toxic phenytoin levels on carobhydrate tolerance and insulin levels was studied in 18 patients with epilepsy and 17 control subjects."3.65The effects of toxic and non-toxic serum phenytoin levels on carbohydrate tolerance and insulin levels. ( Callaghan, N; Cramer, B; Duggan, B; Feely, M; McGarry, J; O'Callaghan, M; Seldrup, J; Wheelan, J, 1977)
"Cerebellar changes have been reported in relationship to epilepsy alone as well as to phenytoin therapy for the control of seizures."3.65Phenytoin-related cerebellar degeneration without seizures. ( Rapport, RL; Shaw, CM, 1977)
"Cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and probenecid were examined in 14 children with epilepsy (ages 6 months to 17 years) and 17 controls (ages 14 months to 16 years)."3.65Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. ( Bowers, MB; Cohen, DJ; Shaywitz, BA, 1975)
"In vitro and in vivo immunologic studies were performed on a 28-year-old woman with phenytoin sodium-induced pseudolymphoma syndrome."3.65Phenytoin-induced pseudolymphoma syndrome: an immunologic study. ( Charlesworth, EN, 1977)
"The influence of clonazepam on steady-state serum levels of diphenylhydantoin, phenobarbital and carbamazepine was studied in 22 patients with epilepsy receiving one or two of these drugs."3.65Lack of effect of clonazepam on serum levels of diphenylhydantoin, phenobarbital and carbamazepine. ( Johannessen, SI; Munthe-Kaas, AW; Strandjord, RE, 1977)
"Severe osteomalacia was present in two epileptic patients who were under long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide."3.65Acetazolamide-accelerated anticonvulsant osteomalacia. ( Mallette, LE, 1977)
"The relationship among the serum concentration of phenytoin, pneumoencephalographic measurements describing, in particular, cerebellar atrophy, and various other clinical variables was analyzed statistically in a series of 131 phenytoin-treated mentally retarded epileptics."3.65Cerebellar atrophy in phenytoin-treated mentally retarded epileptics. ( Helle, EP; Iivanainen, M; Viukari, M, 1977)
" Thirteen ambulant patients suffering from partial epilepsy with complex symptomatology, who were already being treated with phenytoin in optimal doses (plasma level 14-20 mug/ml) were also given carbamazepine."3.65Plasma levels of carbamazepine and carbamazepine-10,11-epoxide during treatment of epilepsy. ( Bertilsson, L; Eichelbaum, M; Lund, L; Palmér, L; Sjöqvist, F, 1976)
"In the CSF's from 13 out of 30 phenytoin-treated patients the IgG concentrations were lower than the lowest amont 20 controls, while only 3 out of 37 patients with brain lesions without epilepsy had so low IgG value."3.65Reduced CSF IgG in patients treated with phenytoin (diphenylhydantoin). ( Fossan, GO, 1976)
"The influence of tolbutamide administration on the plasma concentrations of diphenylhydantoin (DPH) was investigated in seventeen long-stay patients with epilepsy."3.65Interaction of diphenylhydantoin (DPH) and tolbutamide in man. ( Mols-Thürkow, I; Wesseling, H, 1975)
"Two patients with intractable epilepsy who had been treated with various combinations of anticonvulsant drugs developed phenytoin encephalopathy."3.65Choreo-athetosis and encephalopathy induced by phenytoin. ( McLellan, DL; Swash, M, 1974)
"Various immunological features were measured in 20 patients with epilepsy who had received prolonged treatment with hydantoins."3.65Immunological abnormalities and hydantoins. ( Grob, PJ; Herold, GE, 1972)
"Serum phenytoin concentrations in outpatients and inpatients with epilepsy have been contrasted."3.65Supervision of epileptic patients taking phenytoin. ( Dunne, JF; Gibberd, FB; Handley, AJ; Hazleman, BL, 1970)
" Phenobarbital is usually given as well to prevent grand mal seizures."3.64Treatment of epilepsy. ( BAILEY, AA, 1963)
"Phenytoin is a prototypic drug prescribed for the treatment of a variety of seizure disorders."3.01Cutaneous Hypersensitivity Reaction After Phenytoin Therapy in a Neonate: A Case Report and Review of Literature Elucidating the Potential Pharmacological Plausibility and Preventive Strategies. ( Prabath, I; Rajendran, P; Rani, J, 2023)
"Epilepsy is an important cause of morbidity and mortality especially in low- and middle-income countries."3.01Challenges in epilepsy diagnosis and management in a low-resource setting: An experience from Bhutan. ( Chhetri, B; Dhakal, GP; Dorji, T; Jamtsho, S; Nirola, DK; Pema, D; Tenzin, K; Wangmo, S, 2023)
"Fifth, treating neonatal seizures (including electrographic-only seizures) to achieve a lower seizure burden may be associated with improved outcome (expert agreement)."3.01Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures. ( Abend, NS; Auvin, S; Boylan, G; Brigo, F; Cilio, MR; De Vries, LS; Elia, M; Espeche, A; Hahn, CD; Hartmann, H; Inder, T; Jette, N; Kakooza-Mwesige, A; Mader, S; Mizrahi, EM; Moshé, SL; Nagarajan, L; Noyman, I; Nunes, ML; Pressler, RM; Samia, P; Shany, E; Shellhaas, RA; Subota, A; Triki, CC; Tsuchida, T; Vinayan, KP; Wilmshurst, JM; Yozawitz, EG, 2023)
"Epilepsy is a common neurological condition with a worldwide prevalence of around 1%."2.82Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Cividini, S; Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C, 2022)
"Carbamazepine and phenytoin were the drugs most strongly associated with decreases in T4 and T3 levels while topiramate had the greatest elevating effect on TSH."2.82Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis. ( Cai, M; Guo, X; Han, Y; Lin, W; Yang, J; Zhong, R, 2022)
"The phenytoin treatment causes cerebellar defect and anemia."2.82The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches. ( Agrawal, M; Dhurandhar, Y; Panda, SP, 2022)
" Indeed, because of its interesting pharmacokinetic properties, it is often used outside of the labeled indications, notably in the neurocritical setting as prophylaxis of epileptic seizures."2.82Pharmacokinetic considerations surrounding the use of levetiracetam for seizure prophylaxis in neurocritical care - an overview. ( Amadori, E; D'Onofrio, G; Lattanzi, S; Riva, A; Rose, K; Striano, P; Verrotti, A, 2022)
"The clinical spectrum of tics induced by antiepileptic drugs (AED), a form of 'secondary Tourettism', is largely unknown."2.72Tics induced by antiepileptic drugs: a pragmatic review. ( Angus-Leppan, H; Peters, J; Vijiaratnam, N, 2021)
"We systematically reviewed the existing literature on the cosmetic adverse effects of antiseizure medications (ASMs) in order to depict a clear picture of these unwanted side effects of ASMs with a particular attention to hair loss, hirsutism, acne, and gingival hyperplasia."2.72Cosmetic adverse effects of antiseizure medications; A systematic review. ( Asadi-Pooya, AA; Mirzaei Damabi, N; Rostaminejad, M; Zeraatpisheh, Z, 2021)
"The objective of this study was to compare the efficacy and safety of a chronotherapeutic dosing schedule of phenytoin and carbamazepine versus a conventional dosing schedule for the treatment of tonic-clonic epileptic patients."2.72Chronotherapeutic dose schedule of phenytoin and carbamazepine in epileptic patients. ( Mahesh, SD; Sangle, S; Yegnanarayan, R, 2006)
"Seizure activity in patients with acute liver failure (ALF) may increase cerebral oxygen requirements and worsen cerebral edema."2.71Prophylactic phenytoin does not improve cerebral edema or survival in acute liver failure--a controlled clinical trial. ( Acharya, SK; Batra, Y; Bhatia, V, 2004)
" We measured the plasma phenytoin concentrations at steady-state in 20 routinely treated Japanese patients, and evaluated the usefulness of genotyping the CYP2C subfamily in predicting plasma concentrations and determining the dosage regimens of phenytoin."2.71Evaluation of phenytoin dosage regimens based on genotyping of CYP2C subfamily in routinely treated Japanese patients. ( Aiba, T; Hashimoto, Y; Hongou, K; Miyawaki, T; Taguchi, M; Takizawa, M; Yagi, S, 2005)
"All phenytoin was administered intravenously, and fosphenytoin was given intravenously or intramuscularly (physician preference)."2.70Randomized evaluation of adverse events and length-of-stay with routine emergency department use of phenytoin or fosphenytoin. ( Clements, EA; Cochran, MS; Coplin, WM; O'Neil, BJ; Rebuck, JA; Rhoney, DH, 2002)
" All prior pharmacokinetic studies had the first plasma sample obtained 30 min after IM administration."2.70Fosphenytoin: pharmacokinetics and tolerance of intramuscular loading doses. ( DeToledo, J; Gidal, B; Morgan, RO; Pryor, FM; Ramsay, RE, 2001)
"Phenytoin (PHT) has been widely used intravenously for the treatment of seizures since 1956, and for many years, it has been considered first-line therapy for status epilepticus."2.70A prospective study of the incidence of the purple glove syndrome. ( Anandan, JV; Barkley, GL; Burneo, JG, 2001)
"The most important factor determining seizure recurrence was continued therapy, which was the case for barbiturates, phenytoin and valproate."2.69Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study. ( Chadwick, D, 1999)
"Phenytoin (PHT) is a widely prescribed antiepileptic drug."2.69Genotoxicity of the anticonvulsant drug phenytoin (PHT): a follow-up study of PHT-untreated epileptic patients. I. Sister chromatid exchange (SCE) analysis. ( Goyle, S; Kaul, A, 1999)
"Before epilepsy was diagnosed there was no difference in overall fracture rate between patients and controls (RR = 1."2.69Fracture risk is increased in epilepsy. ( Dam, M; Mosekilde, L; Rejnmark, L; Tigaran, C; Tigaran, S; Vestergaard, P, 1999)
"Lamotrigine is an effective add-on therapy against a range of epileptic seizure types."2.69Lamotrigine monotherapy in newly diagnosed untreated epilepsy: a double-blind comparison with phenytoin. ( Abbott, R; Dellaportas, CI; Findley, LJ; Gibberd, FB; Gross, M; Park, DM; Perkin, GD; Steiner, TJ, 1999)
" Two analyses of adverse events are presented: tolerability and safety."2.69Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study. ( Bernstein, P; Faught, RE; Holmes, GL; Magnus-Miller, L; McLean, MJ; Morrell, MJ; Privitera, MD; Rose-Legatt, A; Willmore, LJ, 1999)
"Odds for epilepsy were higher among people who had positive family history (O."2.69A case control study and one year follow-up of registered epilepsy cases in a resettlement colony of North India, a developing tropical country. ( Chopra, JS; Kaur, P; Sawhney, IM; Singh, A; Suri, G, 1999)
"This open-label study investigated the pharmacokinetic interaction of phenytoin (PHT) and felbamate (FBM)."2.69Coadministration of phenytoin and felbamate: evidence of additional phenytoin dose-reduction requirements based on pharmacokinetics and tolerability with increasing doses of felbamate. ( Lyness, WH; Perhach, JL; Rosenberg, A; Sachdeo, R; Sachdeo, S; Shumaker, RC; Wagner, ML; Ward, D, 1999)
" No significant difference was observed in any of the pharmacokinetic parameters like Cmax, Cmin, Tmax, t1/2a, t1/2e and AUC of DPH after GFJ administration as compared to control values in healthy volunteers and epileptic patients."2.69Lack of pharmacokinetic interaction between grapefruit juice and phenytoin in healthy male volunteers and epileptic patients. ( Garg, SK; Kumar, N; Prabhakar, S, 1999)
"Fosphenytoin was as well tolerated as intramuscular placebo at the injection site."2.68Safety and tolerance of multiple doses of intramuscular fosphenytoin substituted for oral phenytoin in epilepsy or neurosurgery. ( Campbell, K; Garnett, WR; Henkin, SA; Kugler, AR; Pellock, JM; Ramsay, RE; Wilder, BJ, 1996)
" When PB in the dosage of 30-60 mg/d was used in combination with PHT the above mentioned changes were not observed."2.68Brainstem auditory evoked potentials in epileptics on different anti-epileptic drugs. ( Gupta, HL; Mukhopadhyay, S; Panjwani, U; sel Vamurthy, W; Singh, SH; Thakur, L, 1996)
"Lamotrigine (LTG) is a new antiepileptic drug (AED), chemically unrelated to the drugs in current use."2.68Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication. ( Jürgens, U; May, TW; Rambeck, B, 1996)
"The population pharmacokinetic parameters of phenytoin were estimated using routine therapeutic drug monitoring data from 116 epileptic patients."2.68Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: analysis with a dose-dependent clearance model. ( Furusho, K; Hashimoto, Y; Hattori, H; Inui, K; Koue, T; Odani, A; Otsuki, Y; Takano, M; Takayanagi, K; Yasuhara, M, 1996)
"To develop simple clinical rules for dosing phenytoin (PHT) using computer simulations, then to test the rules for accuracy and safety on actual patient data."2.67Clinical rules for phenytoin dosing. ( Privitera, MD, 1993)
"On treatment with carbamazepine (n = 27) and phenytoin (n = 8), the excretion of alpha 1-microglobulin was significantly increased, as compared with the healthy controls."2.67Renal tubular dysfunction following treatment with anti-epileptic drugs. ( Korinthenberg, R; Wehrle, L; Zimmerhackl, LB, 1994)
" Each patient received an individualized loading dose and maintenance dosage targeted at a 60-ng/ml plasma FNR concentration."2.67Flunarizine for treatment of partial seizures: results of a concentration-controlled trial. ( Drake, ME; Mikati, M; Olson, L; Pellock, JM; Pledger, GW; Sackellares, JC; Sahlroot, JT; Treiman, DM; Tsay, JY; Wright, FS, 1994)
"We estimated individual and population Michaelis-Menten pharmacokinetic parameters for phenytoin (DPH) in epileptic patients attending our neurology clinic using the computer programme."2.67Pharmacokinetics of phenytoin in routine clinic patients in Malaysia. ( Chand, P; Ismail, R; Rahman, AF, 1994)
" Consequently, the controlled trial was designed to account for this interaction by reducing the phenytoin dosage by approximately 20% during the felbamate treatment period and using matching placebo capsules to maintain the blind."2.67Dosage adjustments in response to monitored plasma concentrations: can unblinded staff adhere to objective criteria? ( Pledger, GW; Sahlroot, JT, 1994)
" Median AUCs of CBZ, VPA and PHT during a dosage interval did not differ significantly after treatment with OXC and placebo."2.67A double-blind, placebo-controlled interaction study between oxcarbazepine and carbamazepine, sodium valproate and phenytoin in epileptic patients. ( Blacklaw, J; Brodie, MJ; Connelly, D; Forrest, G; Gillham, RA; McKee, PJ; Walker, SM, 1994)
" The results suggest that no overall dosage adjustments are required when switching from one brand to the other."2.67Comparison of the effectiveness of two oral phenytoin products and chronopharmacokinetics of phenytoin. ( Morton, DJ; Petker, MA, 1993)
"Felbamate is a novel antiepileptic drug that is now available in the United States."2.67Effect of felbamate on carbamazepine and its major metabolites. ( Graves, NM; Leppik, IE; Remmel, RP; Wagner, ML, 1993)
"The comparative bioavailability of two phenytoin products, Phenytoin Sodium (CAPS (Pvt) Ltd) and Epanutin (Parke-Davis (Pty) Ltd) was studied."2.66A comparative bioavailability of 2 oral solid phenytoin dosage forms. ( Morton, DJ; Naik, D, 1989)
"1."2.66A multicentre study of vigabatrin for drug-resistant epilepsy. ( Ben-Menachem, E; Browne, TR; Mattson, RH; Miketta, RM; Penry, JK; Sherry, KM; Smith, DB; Szabo, GK; Treiman, DM; Wilder, BJ, 1989)
"Safety and efficacy studies of new antiepileptic drugs require strict adherence to prescribed dosage regimens."2.66Compliant populations: variability in serum concentrations. ( Graves, NM; Holmes, GB; Leppik, IE, 1988)
"Both carbamazepine and phenytoin were associated with significantly lower incidences of intolerable side effects than were primidone or phenobarbital."2.66Results of a nationwide Veterans Administration Cooperative Study comparing the efficacy and toxicity of carbamazepine, phenobarbital, phenytoin, and primidone. ( Collins, JF; Craft, B; Cramer, JA; Mattson, RH; Novelly, RA; Smith, DB, 1987)
"Decreased libido and impotence were more common in patients given primidone."2.66Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. ( Browne, TR; Collins, JF; Cramer, JA; Delgado-Escueta, AV; Mattson, RH; McCutchen, CB; McNamara, JO; Smith, DB; Treiman, DM; Williamson, PD, 1985)
"Phenytoin has been widely prescribed alone; our results indicate that sodium valproate may also be used as a single drug in the treatment of several types of epilepsy."2.65Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy. ( Johnson, RH; Lambie, DG; Melville, ID; Nanda, RN; Shakir, RA, 1981)
" Absolute bioavailability of IM PB was 101 +/- 11%."2.65Kinetics of phenobarbital in normal subjects and epileptic patients. ( Comfort, CP; Friel, PN; Kaluzny, SP; Levy, RH; Wilensky, AJ, 1982)
" Plasma DPH levels of more than 10 mug/ml were achieved within 16 to 38 hr in the children given loading doses and within 5 days in the conventionally dosed children."2.64Loading and conventional dose therapy with phenytoin in children: kinetic profile of parent drug and main metabolite in plasma. ( Höjer, B; Rane, A; Wilson, JT, 1976)
"Ambulant patients with recently diagnosed generalised or psychomotor seizure disorders or both were randomly assigned to two dosage regimens of phenytoin."2.64Phenytoin dosage in ambulant epileptic patients. ( Alberts, M; Terrence, C, 1978)
" The data indicate that the dosage regimen described is suitable for patients on oral phenytoin who have to be transferred to im drug for short periods."2.64Oral and intramuscular phenytoin. ( Ramsay, RE; Wilder, BJ, 1976)
" We aimed to clarify the effects of genetic polymorphisms in both enzymes on daily PHT maintenance dosage in Asian epileptic patients by meta-analysis."2.58The association between CYP2C9/2C19 polymorphisms and phenytoin maintenance doses in Asian epileptic patients: A systematic review and meta-analysis
. ( Ai, CZ; Li, W; Liao, K; Liu, Y; Yu, X, 2018)
"Epilepsy is a common neurological condition with a worldwide prevalence of around 1%."2.55Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017)
" The impacts of CYP2C19 and multidrug resistance protein 1 C3435T variants on phenytoin pharmacokinetic and clinical outcomes are unclear and require further investigation."2.55Impact of Genetic Polymorphisms on Phenytoin Pharmacokinetics and Clinical Outcomes in the Middle East and North Africa Region. ( Dagenais, R; Elewa, H; Ensom, MHH; Wilby, KJ, 2017)
"Epilepsy is a common neurological condition with a worldwide prevalence of around 1%."2.55Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017)
"Phenytoin has been explored in over 100 different disorders; the last two promising indications tested in the clinic are breast cancer and optic neuritis."2.55Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action. ( Keppel Hesselink, JM; Kopsky, DJ, 2017)
"Epilepsy is one of the most important neurological disorders with high prevalence worldwide."2.53The importance of triazole scaffold in the development of anticonvulsant agents. ( Ayati, A; Emami, S; Foroumadi, A, 2016)
"Epilepsy affects fetal brain development during gestation in pregnant rats, therefore anti-epileptic therapy should be continued during pregnancy."2.53Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats. ( Doğan, Z; Kamışlı, Ö; Soysal, H, 2016)
" This article reviews the contribution of genetic polymorphisms affecting the activity of CYP2C9, the main enzyme responsible for phenytoin metabolism, to the variation in phenytoin clearance and susceptibility to adverse effects."2.52CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects. ( Franco, V; Perucca, E, 2015)
"Epilepsy is the commonest clinical presentation, though it may also present with headache, symptoms of raised intracranial tension, hydrocephalus and ocular symptoms depending upon the localisation of the parasitic cysts."2.52Antiepileptic drugs for seizure control in people with neurocysticercosis. ( Mathew, A; Sharma, M; Singh, T, 2015)
"Seizures and intracranial hemorrhage are possible medical diseases that any obstetrician may encounter."2.49Seizures and intracranial hemorrhage. ( Alexander, JM; Wilson, KL, 2013)
"Acute seizure and status epilepticus constitute one of the major medical emergencies in children."2.48Management of acute seizure and status epilepticus in pediatric emergency. ( Sasidaran, K; Singhi, P; Singhi, S, 2012)
"54; strength of evidence: low) or adverse events (RR 0."2.48Efficacy and safety of innovator versus generic drugs in patients with epilepsy: a systematic review. ( Ashaye, A; Baker, EL; Baker, WL; Coleman, CI; Kluger, J; Phung, OP; Scholle, JM; Talati, R; White, CM, 2012)
"Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin."2.47Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011)
"Studies on mechanisms of seizure generation and propagation have identified new potential targets for AEDs."2.45New antiepileptic drugs: molecular targets. ( Mula, M, 2009)
" Measuring antiepileptic drug levels in body fluids (therapeutic drug monitoring) is frequently used to optimise drug dosage for individual patients."2.44Therapeutic monitoring of antiepileptic drugs for epilepsy. ( Dahl, ML; Kimland, E; Tomson, T, 2007)
"Febrile seizures and epilepsies are common causes of CSE in infants and young children in Japan, followed by benign infantile convulsions (BIC), convulsions with gastroenteritis (CwG), and acute encephalitis with refractory CSE and intractable epilepsy (AECSEE), which are familiar disorders in Japan."2.44Treatment of convulsive status epilepticus in infants and young children in Japan. ( Sugai, K, 2007)
"Phenytoin has been causally implicated in three human cancers: lymphoma, myeloma and neuroblastoma, the latter specifically in the setting of foetal hydantoin syndrome."2.43Cancer risk in people with epilepsy: the role of antiepileptic drugs. ( Driever, PH; Sander, JW; Singh, G, 2005)
"Agents introduced for the treatment of epilepsy have also been usedsimultaneously for psychiatric indications."2.43[Anticonvulsants treatment of psychiatric disorder in elderly patients]. ( Bidzan, L, 2006)
" The concepts of bioavailability and bioequivalence require further consideration."2.41Is generic prescribing acceptable in epilepsy? ( Besag, FM, 2000)
" However, on rare occasions, they can progress to more severe cutaneous disorders, including Stevens-Johnson syndrome and toxic epidermal necrolysis."2.41Therapeutic safety monitoring: what to look for and when to look for it. ( Harden, CL, 2000)
"Epilepsy affects 1."2.41New antiepileptic drugs and preparations. ( Jagoda, A; Yoon, Y, 2000)
"Minimal requirements: seizure-prevention outcome given as fraction of cases; AED or control assigned by random or quasi-random mechanism."2.41Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. ( Temkin, NR, 2001)
" Rates of metabolism in children may be much faster than in nonelderly adults, requiring dosing adjustments to ensure enough medication is used to control seizures."2.41Treatment of epilepsy in 3 specialized populations. ( Leppik, IE, 2001)
" In this model in Wistar rats, animals which do not respond to repeated or chronic administration of anti-epileptic drugs (non-responders) can be separated from animals in whom anti-epileptics are effective (responders)."2.41Animal models of drug-resistant epilepsy. ( Löscher, W, 2002)
"Phenytoin has been associated predominantly with bradyarrhythmias, some of which were fatal."2.40Arrhythmia, heart rate variability, and antiepileptic drugs. ( Kennebäck, G; Tomson, T, 1997)
"Fosphenytoin has recently been approved as a substitute for parenteral phenytoin."2.40New drug therapy for acute seizure management. ( Morton, LD; Pellock, JM; Rizkallah, E, 1997)
"Felbamate, however, has been linked with substantially increased incidence of aplastic anemia, and the other new AEDs have been studied for relatively short periods of time."2.40Pharmacologic and dietary therapies in epilepsy: conventional treatments and recent advances. ( Chapman, DP; Giles, WH, 1997)
"Moreover, the seizure and the epilepsy type may have been incorrectly diagnosed."2.40Antiepileptic drug-induced worsening of seizures in children. ( Belmonte, A; Genton, P; Guerrini, R, 1998)
" When administered intramuscularly, phenytoin is poorly absorbed and can cause hemorrhagic necrosis of the soft tissues at the injection site."2.40Pediatric use of intravenous and intramuscular phenytoin: lessons learned. ( Wheless, JW, 1998)
" Adverse events associated with fosphenytoin generally were related to the central nervous system and were similar to those associated with phenytoin, except for a higher incidence of transient pruritus with fosphenytoin."2.40Clinical experience with fosphenytoin in adults: pharmacokinetics, safety, and efficacy. ( Knapp, LE; Kugler, AR, 1998)
"Enzymatic biotransformation is the principal determinant of the pharmacokinetic properties of most antiepileptic drugs (AEDs), although some agents are excreted by the kidneys predominantly as unchanged drug."2.40Pharmacokinetics of antiepileptic drugs. ( Browne, TR, 1998)
" The long-term use of phenytoin is not recommended for patients with loss of locomotion, marked cognitive impairment, or symptoms and signs of cerebellar disease."2.40Phenytoin: effective but insidious therapy for epilepsy in people with intellectual disability. ( Iivanainen, M, 1998)
"Plasma concentrations of lamotrigine, an antiepileptic drug obtained in three adult controlled clinical trials conducted in the United States were pooled and analyzed using NONMEM, a population pharmacokinetic computer program, to facilitate development of dosing guidelines."2.40Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy. ( Chen, C; Cox, E; Fiedler-Kelly, J; Grasela, TH; Risner, ME; Womble, GP, 1999)
" Because dosing is often modest, cost should rarely be the overriding factor in choosing a drug for a patient with newly diagnosed epilepsy in the developed world."2.40Monostars: an aid to choosing an antiepileptic drug as monotherapy. ( Brodie, MJ, 1999)
"Oxcarbazepine (OXC) was developed to provide a compound chemically similar enough to CBZ to mimic its efficacy and overall safety while improving its side-effect profile."2.40Oxcarbazepine. ( Tecoma, ES, 1999)
" TPM was added to the baseline antiepileptic drug (AED) at a dosage of up to 800 mg/day, after which the baseline drug was discontinued, when possible."2.39Drug interaction profile of topiramate. ( Bourgeois, BF, 1996)
"Sequelae and risk for recurrence of SE are primarily related to the underlying cause."2.39Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. ( Mitchell, WG, 1996)
"Fosphenytoin is a water-soluble disodium phosphate ester of phenytoin that is converted in plasma to phenytoin."2.39Intravenous administration of fosphenytoin: options for the management of seizures. ( DeToledo, J; Ramsay, RE, 1996)
"Fosphenytoin is a new phenytoin prodrug that fulfills many of the properties of an ideal anticonvulsant drug."2.39Intramuscular use of fosphenytoin: an overview. ( Ramsay, RE; Uthman, BM; Wilder, BJ, 1996)
"Fosphenytoin has fewer local adverse effects (e."2.39Pharmacology and pharmacokinetics of fosphenytoin. ( Browne, TR; Eldon, MA; Kugler, AR, 1996)
" Adverse effects of antiepileptic treatment may affect the patient's quality of life to an even greater extent than the occurrence of seizures."2.39Adverse effects of established and new antiepileptic drugs: an attempted comparison. ( Gram, L; Rogvi-Hansen, B, 1995)
" A drug concentration, however, can only be regarded as a guide around which to alter the dosage according to the patient's clinical condition."2.39Optimisation of antiepileptic drug therapy. The importance of serum drug concentration monitoring. ( Yukawa, E, 1996)
"Fosphenytoin has advantages over phenytoin injection that are related to its greater aqueous solubility, which obviates the extreme alkalinity, propylene glycol, and ethanol needed in the injectable phenytoin formulation."2.39Safety of fosphenytoin sodium. ( Benezra, DA; Fierro, LS; Savulich, DH, 1996)
"Vigabatrin is an irreversible inhibitor of GABA transaminase."2.39[Antiepileptic drugs: mechanism of action]. ( Mercadé Cerdá, JM, 1996)
"The diagnosis of myoclonus was more difficult than those of epilepsy, because the clarification of pathogenesis and definition of diagnosis was lacked."2.38[Diagnosis and therapy of epilepsy and myoclonus]. ( Okamoto, Y; Ota, K, 1993)
" The usual phenytoin (PHT) dosage in adults is 4-6 mg/kg per day, but children may need a dosage three to five times higher."2.38Metabolism of antiepileptic medication: newborn to elderly. ( Leppik, IE, 1992)
"Rare, serious adverse effects of antiepileptic drugs (AEDs) include hepatotoxicity and bone marrow suppression."2.38Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy. ( Wyllie, E; Wyllie, R, 1991)
" In order to use these effectively, the critical care nurse must be aware of the indications and controversies surrounding their use, the patho-physiologic conditions that impact on the disposition, and appropriate dosing and monitoring of these agents in the critical care setting."2.38Anticonvulsants: pharmacotherapeutic issues in the critically ill patient. ( Dupuis, RE; Miranda-Massari, J, 1991)
"Valproic acid is a new antiepileptic drug."2.36Valproic acid. Review of a new antiepileptic drug. ( Bruni, J; Wilder, BJ, 1979)
"Valproic acid has become a regular component of antiepileptic therapy."2.36[Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)]. ( Fröscher, W; Gugler, R; Schulz, HU, 1978)
"Phenytoin (PHT) is a first-line antiepileptic drug in clinics, which could decrease neuronal bioelectric activity by blocking the voltage-operated sodium channels."1.91Calcium Phosphate-Based Nanoformulation Selectively Abolishes Phenytoin Resistance in Epileptic Neurons for Ceasing Seizures. ( Cao, D; Guan, Q; Li, M; Luo, Z; Mao, X; Wang, X, 2023)
"Medicinal treatment against epilepsy is faced with intractable problems, especially epileptogenesis that cannot be blocked by clinical antiepileptic drugs (AEDs) during the latency of epilepsy."1.91ROS/Electro Dual-Reactive Nanogel for Targeting Epileptic Foci to Remodel Aberrant Circuits and Inflammatory Microenvironment. ( Chen, Q; Fan, H; Guo, Y; Jiang, C; Li, K; Liu, P; Sun, T; Zhou, Z, 2023)
"Epilepsy is a chronic neurological disorder that is characterized by episodes of seizure."1.72Clinical Evaluation of Levetiracetam in the Treatment of Epilepsy. ( Guan, S; Liu, J; Qian, F; Wang, Y; Wu, H; Yang, J, 2022)
"When selecting an antiseizure medication, consideration should be given to the individual patient's risks of adverse consequences on other organ systems."1.72Long-Term Effects of Antiseizure Medications. ( LoPinto-Khoury, C, 2022)
"Since arrhythmia often accompanies seizures, patients suffering from epilepsy are frequently co-treated with antiepileptic and antiarrhythmic drugs."1.72Ranolazine Interacts Antagonistically with Some Classical Antiepileptic Drugs-An Isobolographic Analysis. ( Banach, M; Borowicz-Reutt, K, 2022)
"Carbamazepine can cause hypersensitivity reactions in ~10% of patients."1.62Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine. ( Carr, DF; Maggs, JL; Marson, AG; Meng, X; Park, BK; Pertinez, H; Pirmohamed, M; Yip, VLM, 2021)
"Epileptic spasms are often preceded by focal (or multifocal) seizures."1.62Potential induction of epileptic spasms by nonselective voltage-gated sodium channel blockade: Interaction with etiology. ( Heesch, J; Hussain, SA; Numis, AL; Rajaraman, RR; Sankar, R; Weng, J, 2021)
"Pharmaco-resistant Epilepsy has been a major challenge for medical interventions in controlling seizures."1.62Gene Expression Analysis Identifies Cholesterol Metabolism Dysregulation in Hippocampus of Phenytoin-Resistant Pentylenetetrazol-Kindled Epileptic Mice. ( Amalakanti, S; Bhat, UA; Chakravarty, S; Khandelwal, N; Kumar, A; Mylavarapu, MB; Sundarachary, NV, 2021)
"Carbamazepine was the second most common drug followed by lamotrigine and valproic acid."1.62Post-stroke epilepsy and antiepileptic drug use in men and women. ( Linnér, L; Loikas, D; Sundström, A; von Euler, M; Wettermark, B, 2021)
" Similar dose-related responses were seen following the week-long dosing protocol for carbamazepine, phenobarbital, and phenytoin, and these responses were associated with drug levels that were in the human therapeutic range."1.62Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency. ( Bertram, EH; Edelbroek, P, 2021)
"Epilepsy is very difficult to treat and often involves the combination of two or more AEDs."1.56Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database. ( Hayashi, T; Noguchi, Y; Tachi, T; Takaoka, M; Teramachi, H, 2020)
"Lacosamide is a novel anticonvulsant that acts by enhancing sodium channel slow inactivation."1.56Therapeutic Monitoring of Lacosamide in Japanese Patients With Epilepsy: Clinical Response, Tolerability, and Optimal Therapeutic Range. ( Araki, Y; Fukushima, Y; Imai, K; Kagawa, Y; Takahashi, Y; Terada, K; Yamamoto, Y, 2020)
"The study aims to test the effect of influenza vaccination on phenytoin, CYP2C9, and IFNγ levels in epileptic patients receiving phenytoin monotherapy METHODS: Thirty-one epileptic patients receiving stable-dose phenytoin monotherapy were enrolled onto the study."1.56Influenza immunization does not predominantly alter levels of phenytoin, and cytochrome P-450 enzymes in epileptic patients receiving phenytoin monotherapy. ( Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Manoyana, N; Nadsasarn, A; Pinyopornpanish, K; Soontornpun, A; Tanprawate, S, 2020)
"His phenytoin dose was increased, and he was started on calcium supplementation."1.51Paradoxical deterioration in seizure control due to anticonvulsant-induced hypocalcaemia. ( Cachia, MJ; Gauci, Z; Mifsud, S; Rizzo, C, 2019)
"Phenytoin has been decreasingly used because of the high interindividual variability in drug concentration and the narrow therapeutic window."1.51Optimal Dosing Regimen of Phenytoin for Korean Epilepsy Patients: From Premature Babies to the Elderly. ( Chae, D; Guk, J; Kim, JH; Lee, SG; Park, K, 2019)
" for population pharmacokinetic modeling."1.51Estimation of Phenytoin Pharmacokinetic Parameters in Saudi Epileptic Patients. ( Alotaibi, M; Alqahtani, S; Alsultan, A; Alzaidi, T, 2019)
" The aim of this study was to develop a population pharmacokinetic (PPK) model to describe serum phenytoin concentrations after the intravenous administration of fosphenytoin in adult and elderly epileptic patients."1.51Population Pharmacokinetic Analysis of Phenytoin After Intravenous Administration of Fosphenytoin in Adult and Elderly Epileptic Patients. ( Higuchi, K; Hirakawa, M; Hirota, T; Ieiri, I; Kakara, M; Kashihara, Y; Yamashita, D, 2019)
" Our aim was to translate a recently published comprehensive CNS physiologically-based pharmacokinetic (PBPK) model from rat to human, and to predict drug concentration-time profiles in multiple CNS compartments on available human data of four drugs (acetaminophen, oxycodone, morphine and phenytoin)."1.48Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach. ( Beukers, MW; Danhof, M; de Lange, ECM; Huntjens, DR; Kokki, H; Kokki, M; Krauwinkel, W; Proost, JH; Välitalo, PA; van Hasselt, JGC; Vermeulen, A; Wong, YC; Yamamoto, Y, 2018)
"Evidence for the comparative teratogenic risk of antiepileptic drugs is insufficient, particularly in relation to the dosage used."1.48Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F, 2018)
" We studied whether glucocorticoid receptor (GR) silencing or inhibition in human epileptic brain endothelial cells (EPI-ECs) functionally impacts drug bioavailability across an in vitro model of the blood-brain barrier (BBB) by CYP-multidrug transporter (multidrug resistance protein 1, MDR1) mechanisms."1.48Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood-brain barrier model. ( Bingaman, W; Ghosh, C; Gonzalez-Martinez, J; Hossain, M; Janigro, D; Khan, S; Marchi, N; Mishra, S; Najm, I, 2018)
"Levetiracetam treatment did not affect bone strength, bone mass, and bone turnover."1.46Effects of the Antiepileptic Drugs Phenytoin, Gabapentin, and Levetiracetam on Bone Strength, Bone Mass, and Bone Turnover in Rats. ( Izumo, N; Kanda, J; Kobayashi, Y; Onodera, K; Shimakura, T; Takahashi, HE; Wakabayashi, H; Yamamoto, N, 2017)
" Therefore, H3Rs may have implications for the treatment of degenerative disorders associated with impaired memory function and may represent a novel therapeutic pharmacological target to tackle cognitive problems associated with the chronic use of antiepileptic drugs."1.43Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats. ( Kieć-Kononowiczc, K; Saad, A; Sadek, B; Shafiullah, M; Subramanian, D; Łażewska, D, 2016)
" Long-term use of phenytoin can lead to axonal shrinkage and random clusters of nerve demyelination [1]."1.43Lacking the 'protective label' of diabetes: Phenytoin-induced distal symmetrical peripheral neuropathy. A clinical case report. ( Mahon, AM, 2016)
"Weight gain and alopecia were the most common patient-reported CSEs in this study, and weight gain was the most likely cosmetic side effect to result in dosage adjustment or medication discontinuation."1.42Cosmetic side effects of antiepileptic drugs in adults with epilepsy. ( Buchsbaum, R; Chen, B; Choi, H; Detyniecki, K; Hirsch, LJ; Javed, A; Kato, K; Legge, A; Moeller, J, 2015)
"To use a physiologically based pharmacokinetic (PBPK) modelling system to predict the serum levels achieved by two different intravenous loading doses of phenytoin."1.42Comparing paediatric intravenous phenytoin doses using physiologically based pharmacokinetic (PBPK) modelling software. ( Appleton, R; Batchelor, H; Hawcutt, DB, 2015)
"CNS inflammation is characterized by a disturbance of glial cell functions."1.40Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation. ( Dambach, H; Faustmann, PM; Haase, CG; Hinkerohe, D; Hufnagel, A; Moinfar, Z; Prochnow, N; Stienen, MN, 2014)
"Phenytoin was most commonly implicated (93 %) in rash formation compared with other AEDs (P < 0."1.40EMPACT syndrome: limited evidence despite a high-risk cohort. ( Barker, CA; Bishop, AJ; Chang, M; Lacouture, ME, 2014)
"Phenytoin-treated kindled animals were associated with learning and memory deficit, while tacrine supplementation improved memory deficit with increased seizure severity score."1.40Adjuvant anticholinesterase therapy for the management of epilepsy-induced memory deficit: a critical pre-clinical study. ( Goel, RK; Mishra, A, 2014)
"Tamoxifen is a prodrug, requiring cytochrome P450 enzyme-mediated metabolism to form the active metabolite endoxifen."1.40Profound reduction in the tamoxifen active metabolite endoxifen in a patient on phenytoin for epilepsy compared with a CYP2D6 genotype matched cohort. ( Gryn, SE; Kim, RB; Teft, WA, 2014)
" In order to evaluate the oral bioavailability of PHT, two groups were administered with oral or intraperitoneal doses of 100mg/kg and plasma level were measured."1.40Chronic administration of phenytoin induces efflux transporter overexpression in rats. ( Alvariza, S; Fagiolino, P; Feria-Romero, I; Orozco-Suárez, S; Vázquez, M, 2014)
"Myotonic dystrophy is a clinically and genetically heterogeneous multisystem disorder with a prevalence of 1 in 8000 in the general population."1.40Concurrence of myotonic dystrophy and epilepsy: a case report. ( Worku, DK, 2014)
" In phase IV screening, the bioavailability of active compounds was assessed on oral administration."1.40Preliminary anticonvulsant and toxicity screening of substituted benzylidenehydrazinyl-N-(6-substituted benzo[d]thiazol-2-yl)propanamides. ( Ali, R; Siddiqui, N, 2014)
"Hyperammonemia was defined as a plasma ammonia level exceeding 100 μg/dl with reference to the standard range and previous reports."1.39Risk factors for hyperammonemia in pediatric patients with epilepsy. ( Imai, K; Inoue, K; Inoue, Y; Itoh, K; Kagawa, Y; Mishima, N; Takahashi, Y; Yamamoto, Y; Yazawa, R, 2013)
"Phenytoin is known to cause conduction slowing."1.39Fosphenytoin induced transient pendular nystagmus. ( Shaikh, AG, 2013)
" P-gp polymorphisms may also affect phenytoin efficacy by altering its bioavailability (F)."1.39Studies on pharmacokinetic mechanism of phenytoin resistance in refractory epilepsy. ( Huang, JD; Huang, YS; Lai, ML; Tien, YE, 2013)
"To investigate PHT performance in reaching therapeutic target serum concentration rapidly and sustainably, a Bayesian forecasting (BF) regimen was compared to conventional dosing (CD), according to the official summary of product characteristics."1.39Intravenous phenytoin: a retrospective analysis of Bayesian forecasting versus conventional dosing in patients. ( Mühlebach, S; Tobler, A, 2013)
" Nevertheless, although the association of these genes with PTH-induced adverse effects has been well-documented in adult populations, this is the first report examining the influence of these genetic polymorphisms on PTH plasma levels and toxicity in a pediatric patient."1.39Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms. ( Dorado, P; Llerena, A; López-Torres, E; Martínez-Antón, J; Peñas-Lledó, EM, 2013)
" In addition, there appeared to be a dose-response relationship between stroke risk and PHT prescriptions."1.39Comparative stroke risk of antiepileptic drugs in patients with epilepsy. ( Hsieh, CY; Lai, EC; Lin, SJ; Yang, YH, 2013)
"Phenytoin plasma levels were analyzed by reversed phase HPLC method and pharmacokinetic parameters such as area under the concentration curve (AUC), maximum concentration (C(max)), time to C(max) (t(max)) and half-life (t(1/2)) were estimated by noncompartmental analysis using PK Solutions® software."1.38Genetic polymorphism of NAT2 metabolizing enzymes on phenytoin pharmacokinetics in Indian epileptic patients developing toxicity. ( Jain, DC; Madhuri, B; Manjari, T; Murali, M; Raghavan, S; Vivekanandhan, S, 2012)
"Phenytoin was used in 56 patients (22%) with the majority (n= 43) receiving intravenous phenytoin."1.38Seizure management at Auckland City Hospital Emergency Department between July and December 2009: time for a change? ( Bergin, P; Jones, P; Rosemergy, I; Walker, E, 2012)
"Phenobarbital has been in clinical use as an antiepileptic drug (AED) since 1912."1.38How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)? ( Bialer, M, 2012)
"Phenytoin levels were undetectable despite a high dose."1.37Reduced phenytoin levels in an epileptic patient following Roux-En-Y gastric bypass for obesity. ( Footitt, D; Mahon, D; Pournaras, DJ; Welbourn, R, 2011)
"Stroke is the major cause of acquired epilepsy in the adult population."1.37An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges. ( Delorenzo, RJ; Deshpande, LS; Ziobro, JM, 2011)
"We determined PHT bioavailability during steady-state therapy by 1) measurement of the two principal deconjugated PHT urinary metabolites, 5-(4-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) and 5-(3,4-dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin (DHD); and 2) direct determination of absolute bioavailability after simultaneous administration of an oral formulation and parenteral stable-labeled PHT (SL-PHT)."1.37Excretion of the principal urinary metabolites of phenytoin and absolute oral bioavailability determined by use of a stable isotope in patients with epilepsy. ( Aliwarga, T; Brundage, RC; Cloyd, JC; Goel, V; Leppik, IE; Marino, SE; Remmel, RP, 2011)
"  We identified significant associations of CYP2C9 variant alleles with presence of phenytoin (PHT) adverse drug reactions (ADRs) and of GSTM1 copy number variation with the presence of carbamazepine ADRs."1.37A candidate gene study of antiepileptic drug tolerability and efficacy identifies an association of CYP2C9 variants with phenytoin toxicity. ( Da Cruz, AL; Depondt, C; Espel, RS; Godard, P; Lienard, P; Pandolfo, M, 2011)
"Phenytoin use was associated with a statistically significant increased risk of fractures OR=1."1.37Association of antiepileptic drugs, vitamin D, and calcium supplementation with bone fracture occurrence in epilepsy patients. ( Abner, E; Espinosa, PS; Perez, DL; Ryan, M, 2011)
" The drug combination elevated the plasma level of PHT in a patient on chemotherapy with capecitabine for colorectal cancer."1.37[A case of toxicity caused by drug interaction between capecitabine and phenytoin in patient with colorectal cancer]. ( Fukui, E; Kawahara, K; Sakurai, M; Ueda, R; Yamada, R, 2011)
"Curcumin was co-administered with sub-therapeutic dose of valproate 60min before PTZ injection."1.37Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. ( Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH, 2011)
"Phenytoin levels were subjected to analysis of variance and the dose effect was approached using a multiple comparison test."1.37Capecitabine-phenytoin interaction is dose dependent with an unexpected time course. ( de Los Ríos la Rosa, F; Privitera, M, 2011)
"Epilepsy was confirmed in 58 cases."1.37[Epilepsy in elderly]. ( Kotov, AS; Rudakova, IG, 2011)
"Epileptic seizures drive expression of the blood-brain barrier efflux transporter P-glycoprotein via a glutamate/cyclooxygenase-2 mediated signalling pathway."1.36COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats. ( Aronica, E; Edelbroek, PM; Gorter, JA; Holtman, L; Pekcec, A; Potschka, H; Schlichtiger, J; van Vliet, EA; Zibell, G, 2010)
"Antiepileptic drugs (AEDs) have been widely used in patients with epilepsy but the adverse effects in adult Chinese patients have not been investigated."1.36Adverse effects of carbamazepine, phenytoin, valproate and lamotrigine monotherapy in epileptic adult Chinese patients. ( Wang, X; Xi, Z; Yan, Y; Zeng, K, 2010)
"Phenytoin is a widely used anti-seizure agent, and a good correlation is observed between its concentration in plasma and the clinical effect."1.36Determination of free and total levels of phenytoin in human plasma from patients with epilepsy by MEKC: an adequate alternative to HPLC. ( Chen, SH; Hsieh, YH; Liao, FF; Lin, PC, 2010)
"Phenytoin was subsequently administered for seizure prophylaxis."1.35Phenytoin toxicity due to genetic polymorphism. ( Bullock, MR; McCluggage, LK; Voils, SA, 2009)
"Phenytoin levels were measured and found to be grossly elevated at 170 mmol/L."1.35Phenytoin toxicity and thyroid dysfunction. ( Betteridge, T; Fink, J, 2009)
" TDM requests, interpretation and dosage adjustment recommendations were mainly responsible by residents."1.35Effect of pharmacist participation in the health care team on therapeutic drug monitoring utilization for antiepileptic drugs. ( Faroongsarng, D; Kaewpibal, P; Ratanajamit, C; Setthawacharavanich, S, 2009)
"Epilepsy has been associated with poor obstetric outcomes that could be the result of the epilepsy itself or a direct effect of anti-epileptic medication on placentation."1.35Phenytoin but not valproate directly affected in vitro trophoblast differentiation. ( Anin, S; Bates, MD; Chadwick, D; Neilson, JP; Quenby, SM; Vince, GS, 2008)
"Phenytoin is a drug used for the treatment of different types of seizures."1.35Undetectable phenytoin serum levels by an automated particle-enhanced turbidimetric inhibition immunoassay in a patient with monoclonal IgM lambda. ( Brauchli, YB; Krähenbühl, S; Scholer, A; Schwietert, M, 2008)
" The pharmacokinetics of the 260 PB concentrations at a steady-state obtained from 79 patients was described with a one-compartment open pharmacokinetic model with first-order elimination."1.34Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese. ( Goto, S; Ishitsu, T; Murata, T; Nakada, N; Nakagawa, K; Seo, T; Ueda, N, 2007)
"In phenobarbital-treated patients, serum levels in 73% of the patients were in therapeutic range of 10-40 microg/ml, and about 44% of phenytoin-treated patients had serum levels in therapeutic range of 10-20 microg/ml."1.34Evaluation of therapeutic drug level monitoring of phenobarbital, phenytoin and carbamazepine in Iranian epileptic patients. ( Babaei, A; Eslamai, MH, 2007)
"PPhenytoin was 10-fold less (1."1.34Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs. ( Cucullo, L; Hossain, M; Janigro, D; Manders, T; Marchi, N; Rapp, E, 2007)
"Those with epilepsy at diagnosis of macroprolactinoma were examined in detail."1.34Macroprolactinomas and epilepsy. ( Daousi, C; Deepak, D; Javadpour, M; MacFarlane, IA, 2007)
"Interindividual variability in intestinal absorption and bioavailability might contribute to inadequate control of seizures under treatment with carbamazepine and phenytoin."1.34Intestinal expression of cytochrome P450 enzymes and ABC transporters and carbamazepine and phenytoin disposition. ( Fried, M; Fritschy, JM; Kullak-Ublick, GA; Mueller, S; Pauli-Magnus, C; Simon, C; Stieger, B; Wieser, HG, 2007)
"Treatment with phenobarbital or phenytoin caused a reduction in seizure frequency, but did not improve EEG background or prevent death."1.34The natural history and treatment of epilepsy in a murine model of tuberous sclerosis. ( Erbayat-Altay, E; Gutmann, DH; Wong, M; Xu, L; Zeng, LH, 2007)
" Further investigations with an approach to dose assessment that includes comprehensive interpretation of both pharmacogenetic and pharmacokinetic data along with understanding of the mechanism of drug interactions in dosage adjustment is warranted."1.34Contributions of CYP2C9/CYP2C19 genotypes and drug interaction to the phenytoin treatment in the Korean epileptic patients in the clinical setting. ( Kim, JW; Lee, ST; Lee, SY, 2007)
" These results provide evidence of a drug target polymorphism associated with the clinical use of AEDs and set the stage for a prospective evaluation of how pharmacogenetic diagnostics can be used to improve dosing decisions in the use of phenytoin and carbamazepine."1.33Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin. ( Cavalleri, GL; Depondt, C; Goldstein, DB; Sander, JW; Schorge, S; Sen, A; Shorvon, SD; Sisodiya, SM; Soranzo, N; Tate, SK; Thom, M; Wood, NW, 2005)
"Permeability of the blood-brain barrier is one of the factors determining the bioavailability of therapeutic drugs and resistance to chemically different antiepileptic drugs is a consequence of decreased intracerebral accumulation."1.33RLIP76, a non-ABC transporter, and drug resistance in epilepsy. ( Awasthi, S; Awasthi, YC; Cucullo, L; Dini, G; Fazio, V; Hallene, KL; Janigro, D; Singhal, SS, 2005)
"Thus it is necessary to rule out ictal catatonia by electroencephalography in patients with catatonic stupor."1.33Epileptic seizures superimposed on catatonic stupor. ( Awata, S; Ebina, Y; Honda, T; Matsuoka, H; Miura, N; Shindo, T; Suzuki, K; Takano, T, 2006)
" The mean plasma drug concentrations at different time points and the pharmacokinetic parameters before and after piperine administration were compared by Student's t-test."1.33Effect of piperine on the steady-state pharmacokinetics of phenytoin in patients with epilepsy. ( Hota, D; Kharbanda, P; Pandhi, P; Pattanaik, S; Prabhakar, S, 2006)
" This has implications for dosing regimens relying on plasma phenytoin levels."1.33Free phenytoin concentration measurement in brain extracellular fluid: a pilot study. ( Belli, A; Kitchen, N; Patsalos, P; Petzold, A; Ratnaraj, N; Russo, S; Sen, J; Smith, M; Tisdall, M, 2006)
"A 9-year-old girl with akinetic-rigid parkinsonism with tremor is described."1.33Epilepsy, parkinsonism, and neuroleptic malignant syndrome in a child. ( Cantú-Martínez, L; Flores, Lde L; González, HC; Martínez, HR; Onofre-Castillo, J; Villarreal, HJ, 2006)
"Phenytoin is a known inducer of drugs metabolized by CYP2C, CYP2D, and CYP3A, but its own metabolism may be altered by drugs influencing CYP2C9 or CYP2C19, such as diazepam."1.32Phenytoin-diazepam interaction. ( Murphy, A; Wilbur, K, 2003)
"Oxcarbazepine was generally well tolerated during monotherapy and adjunctive therapy; 2."1.32Spotlight on oxcarbazepine in epilepsy. ( Bang, LM; Goa, KL, 2004)
"The average annual cost of outpatient treatment of epilepsy was found to be 47 US dollars per patient."1.32Cost of epilepsy in patients attending a secondary-level hospital in India. ( Kapoor, SK; Krishnan, A; Sahariah, SU, 2004)
"We describe the incidence of newly treated epilepsy in primary care and patterns of antiepileptic drug prescription, numbers of patients who remain on initial therapy and health service utilisation."1.32The outcome of initiation of antiepileptic drug monotherapy in primary care: a UK database survey. ( Buchan, S; Kerr, MP; Morgan, CL, 2004)
"Phenytoin (PHT) dosing regimens are often determined based on experience in those aged <65 years rather than in those aged >or=65 years."1.32Phenytoin use in elderly nursing home residents. ( Birnbaum, AK; Bowers, SE; Conway, JM; Graves, NM; Hardie, NA; Lackner, TE; Leppik, IE, 2003)
"The purpose of this study was to investigate the relationship of changes in the enzyme-inducing anticonvulsant daily dosage (drug score) to variations in urinary D-glucaric acid excretion and gamma-glutamyltransferase and beta-glucuronidase serum activities."1.31Relationship between changes in drug score, D-glucaric acid excretion, and gamma-glutamyltransferase and beta-glucuronidase serum activities during anticonvulsant treatment. ( Fernández, MP; Hermida, J; Tutor, JC, 2002)
"A 21-year-old female with West syndrome was scheduled for resection of hordeolum."1.31[Anesthetic management of a patient with West syndrome]. ( Kitajima, T; Mishio, M; Okuda, Y; Yamaguchi, S, 2000)
"Phenytoin toxicity was defined by clinical features and correlated with drug levels."1.31Elimination of phenytoin in toxic overdose. ( Chan, SP; Chua, HC; Tjia, H; Venketasubramanian, N, 2000)
"Topiramate also may inhibit synaptic conductances responsible for transmission of epileptiform discharges."1.31Effects of topiramate on sustained repetitive firing and spontaneous recurrent seizure discharges in cultured hippocampal neurons. ( Coulter, DA; DeLorenzo, RJ; Sombati, S, 2000)
"Phenytoin nonresponders were proposed as a model for pharmaco-resistant temporal lobe epilepsy."1.31Kindling alters the anticonvulsant efficacy of phenytoin in Wistar rats. ( Ebert, U; Löscher, W; Reissmüller, E, 2000)
" The validity of the pharmacokinetic models and the estimated population parameter values was tested using the naive prediction method."1.31Validation of population pharmacokinetic parameters of phenytoin using the parallel Michaelis-Menten and first-order elimination model. ( Folb, PI; McFadyen, ML; Miller, R; Seymour, MA; Valodia, PN, 2000)
"Levetiracetam has recently been approved as an adjunctive medication for partial seizures and frequently will be added to phenytoin."1.31Absence of pharmacokinetic drug interaction of levetiracetam with phenytoin in patients with epilepsy determined by new technique. ( Baltes, E; Browne, TR; Jensen, CM; Josephs, E; Leppik, IE; Paz, J; Szabo, GK, 2000)
" Since phenytoin has a narrow therapeutic index and genotyping may be carried out rapidly and at low cost, dosage adjustment based on CYP2C9 genotype, especially at the induction of therapy, would be of value in order to lower the risk of concentration dependent drug intoxications in carriers."1.31The effect of genetic polymorphism of cytochrome P450 CYP2C9 on phenytoin dose requirement. ( de Haan, K; Steijns, LS; van der Weide, J; van Weelden, MJ, 2001)
"Chorea is a rare side effect of anticonvulsants."1.31Anticonvulsants-induced chorea: a role for pharmacodynamic drug interaction? ( Beach, RL; D'Cruz, O; Tennison, M; Zaatreh, M, 2001)
"Phenytoin is an effective anticonvulsant, but high serum phenytoin concentrations may be associated with serious toxicity."1.31How high can we go with phenytoin? ( Kobayashi, J; Koren, G; Kozer, E; Minassian, BA; Parvez, S; Verjee, Z, 2002)
" For males, the peak concentration at 9."1.30Single oral loading dose of phenytoin: a pharmacokinetics study. ( Kaojarern, S; Mokkhavesa, C; Phuapradit, P; Ratanakorn, D, 1997)
" The purpose of our study was to evaluate the effects of chronic administration of valproate (VPA), phenytoin (PHT), and MK-801 on the change in seizure phenotype observed in our model system."1.30Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis. ( Applegate, CD; Ozduman, K; Samoriski, GM, 1997)
" AWD 140-190 thus presents an orally active and safe anticonvulsant agent, which is structurally unrelated to anticonvulsants currently used."1.30AWD 140-190: a new anticonvulsant with a very good margin of safety. ( Bartsch, R; Engel, J; Rostock, A; Rundfeldt, C; Tober, C; Unverferth, K; White, HS; Wolf, HH, 1997)
"Phenytoin dosing is often difficult in a clinical situation because of the non-linear nature of phenytoin metabolism at therapeutic plasma concentrations."1.30Single-point phenytoin dosage predictions in Singapore Chinese. ( Chan, E, 1997)
"Phenytoin is a major antiepileptic drug for treatment of limbic seizures."1.30Phenytoin's effect on the spread of seizure activity in the amygdala kindling model. ( Cramer, S; Ebert, U; Löscher, W, 1997)
"Invasive or complex treatments for epilepsy with partial and generalized tonic-clonic seizures should not be used until at least two AEDs have failed to control seizures."1.30If a first antiepileptic drug fails to control a child's epilepsy, what are the chances of success with the next drug? ( Camfield, CS; Camfield, PR; Dooley, JM; Gordon, K, 1997)
"Epilepsy is a relatively common problem in children, adults and the elderly."1.30Treatment of the epileptic patient in the dental office. ( Haller, JS; Kennedy, BT, 1998)
"When phenytoin, 50 mg/kg, was administered i."1.30Limbic epileptogenesis alters the anticonvulsant efficacy of phenytoin in Sprague-Dawley rats. ( Cramer, S; Ebert, U; Löscher, W, 1998)
"Two pharmacoeconomic studies on the treatment of acute seizures have been conducted."1.30Pharmacoeconomic considerations in treatment options for acute seizures. ( Graves, N, 1998)
" A further difference to the Wistar strain is the truncated dose-response with loss of anticonvulsant efficacy at 75 mg/kg in kindled Sprague-Dawley rats, which may, at least in part, explain the inconsistent results reported on the anticonvulsant efficacy of PHT in this strain in the literature."1.30Selection of phenytoin responders and nonresponders in male and female amygdala-kindled Sprague-Dawley rats. ( Cramer, S; Ebert, U; Löscher, W, 1998)
" In addition, a population pharmacokinetic analysis was performed."1.30The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics. ( Higuchi, S; Ieiri, I; Imai, J; Mamiya, K; Ninomiya, H; Otsubo, K; Shimamoto, J; Tashiro, N; Yamada, H; Yukawa, E, 1998)
"The influence of various covariates (including weight, race, smoking, gender, age, mild-to-moderate alcohol intake, and body surface area) on the population pharmacokinetic parameters of phenytoin in adult epileptic patients in South Africa was investigated."1.30Factors influencing the population pharmacokinetic parameters of phenytoin in adult epileptic patients in South Africa. ( Folb, PI; McFadyen, ML; Miller, R; Seymour, MA; Valodia, P, 1999)
"Phenytoin (PH) levels were determined in the head hair of twenty five patients (fourteen males and eleven females, aged from five to seventy seven years old) who were receiving this drug chronically."1.30Determination of phenytoin in sections of head hair: a preliminary study to evaluate the history of drug use. ( Assithianakis, P; Helidonis, E; Michalodimitrakis, MN; Psillakis, T; Stefis, A; Tsatsakis, AM; Vlahonikolis, IG, 1998)
" PB was also the most toxic drug, followed by CBZ and by PHT."1.30Anticonvulsant and neurotoxic effects of intracerebroventricular injection of phenytoin, phenobarbital and carbamazepine in an amygdala-kindling model of epilepsy in the rat. ( Alós, M; Barcia, JA; Belda, V; Rubio, P; Serralta, A, 1999)
"Phenytoin toxicity is an uncommon problem seen in clinical practice."1.30Paradoxical seizures in phenytoin toxicity. ( Chua, HC; Tan, CB; Tjia, H; Venketasubramanian, N, 1999)
" Valproate, when the proper therapeutic dosage was belatedly realized, was seen as a superior treatment for generalized and partial epilepsies."1.30Clinical experience with new antiepileptic drugs: antiepileptic drugs in Europe. ( Loiseau, PJ, 1999)
" Subsequent determination of individual-specific DPH maintenance dosage and volume of distribution data suitable for use in routine therapeutic concentration management procedures."1.30Practical management of therapeutic diphenylhydantoin concentrations in children. ( Parkin, DP; Schoeman, JF; Seifart, HI; Smit, A, 1999)
" They were taking PHT in a dosage ranging from 100 to 300 mg daily, in mono or polytherapy regimen, during 1-5 previous years."1.30Phenytoin as the first option in female epileptic patients? ( da Silva, VR; Molinari, MA; Trevisol-Bittencourt, PC; Troiano, AR, 1999)
"We present the case of a patient that after chronic use of anticonvulsant drugs without proven epilepsy, developed Dupuytren's and Ledderhose's diseases."1.30[Dupuytren's and Ledderhose's diseases associated with chronic use of anticonvulsants. Case report]. ( Coral, P; Correa Neto, Y; Nóvak, EM; Teive, HA; Werneck, LC; Zanatta, A, 1999)
"Phenytoin (DPH) is a widely used anticonvulsant drug but a conclusive mode of action is not yet clear."1.29Effect of chronic administration of phenytoin on regional monoamine levels in rat brain. ( Lakshmana, KM; Meshkibaf, MH; Rao, BS; Subhash, MN, 1995)
"The medication regimens used to treat epilepsy are further complicated by the fact that most seizure medications are metabolized in the liver and have the potential for serious pharmacokinetic drug-drug interactions with many other medications."1.29Practical considerations in anticonvulsant therapy--Part 2. ( Cloyd, J; Garnett, WR; Holmes, GL; Meyer, MC; Schiffer, JR, 1995)
"Treatment with phenytoin did not influence the results."1.29Positron emission tomographic study of late-onset cryptogenic symptomatic seizures. ( Crevits, L; De Reuck, J; Decoo, D; Goethals, P; Lemahieu, I; Santens, P; Strijckmans, K; Van Maele, G, 1995)
"Routine clinical pharmacokinetic data collected from epileptic out-patients who received phenytoin (PHT) were analysed to estimate population pharmacokinetic parameters."1.29[NONMEM approach for estimating population pharmacokinetic parameters of phenytoin in Chinese epileptics]. ( Cai, MH; Chen, G; Chu, XM; Rui, JZ, 1995)
"Phenytoin-treated patients had a significant reduction in the mean IgA and IgG levels compared to healthy and epileptic controls (P < 0."1.29Humoral and cellular immune parameters in untreated and phenytoin-or carbamazepine-treated epileptic patients. ( Başaran, N; Ciğer, A; Hincal, F; Kansu, E, 1994)
"Trends in treatment of epilepsy in an institution for handicapped patients with epilepsy were investigated in a retrospective longitudinal study."1.29[Changes in drug therapy and in seizure frequency in an institution for epilepsy patients between 1971 and 1986]. ( May, T; Wohlhüter, M; Wolf, P, 1994)
" A review of published studies involving small numbers of elderly subjects or patients given phenytoin sodium, valproic acid, or carbamazepine demonstrates decreased protein binding and intrinsic clearance and increased half-life with advancing age."1.29Antiepileptics in the elderly. Pharmacoepidemiology and pharmacokinetics. ( Cloyd, JC; Lackner, TE; Leppik, IE, 1994)
"Diazepam was the first line treatment in 98 episodes, chlormethiazole and phenytoin were used in 27 and 18 episodes, respectively."1.29Status epilepticus: management and outcome of 107 episodes. ( Martin, PJ; Millac, PA, 1994)
" In this context, anticonvulsant and neurotoxic pharmacodynamic interactions between phenytoin (PHT) and valproate (VPA) were assessed in an experimental model in mice."1.29Pharmacodynamic interactions between phenytoin and valproate: individual and combined antiepileptic and neurotoxic actions in mice. ( Bourgeois, BF; Chez, MG; Knowles, WD; Pippenger, CE, 1994)
"Free phenytoin was determined in plasma from epileptic patients and the results were compared to those obtained by ultrafiltration."1.29Automated determination of free phenytoin in human plasma with on-line equilibrium dialysis and column-switching high-performance liquid chromatography. ( Andresen, AT; Rasmussen, KE; Rugstad, HE, 1993)
"Phenytoin is a potent inducer of carbamazepine metabolism."1.29Unmasking the significant enzyme-inducing effects of phenytoin on serum carbamazepine concentrations during phenytoin withdrawal. ( Abou-Elkair, M; Chapron, DJ; LaPierre, BA, 1993)
" Plasma concentrations of total phenytoin, unbound phenytoin, and the major metabolite of phenytoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin, were measured, and pharmacokinetic variables obtained before and after barbiturate therapy were compared."1.29Effect of barbiturate therapy on phenytoin pharmacokinetics. ( Abe, J; Asada, A; Fujimori, M; Kaji, A; Nishi, S; Oda, Y; Yoshida, N, 1993)
"Two protocols were used: assessment of seizures immediately after the completion of the kindling procedure and after the 2-week postkindling PTX-free period, as compared with acute PTX seizures."1.29Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models. ( Godlevsky, LS; Mazarati, AM; Shandra, AA; Vastyanov, RS, 1996)
"D-Cycloserine (DCS) is a high-efficacy partial agonist at the strychnine-insensitive glycine modulatory site within the N-methyl-D-aspartate (NMDA)-receptor/ionophore complex."1.29Influence of D-cycloserine on the anticonvulsant activity of phenytoin and carbamazepine against electroconvulsions in mice. ( Czuczwar, SJ; Roliński, Z; Wlaź, P, 1996)
" Thirty-six adult epileptic patients who had been receiving phenytoin for greater than 6 months without a recent change in dosage were assessed for signs of periodontal disease and gingival overgrowth."1.29Plasma and saliva concentrations of phenytoin and 5-(4-hydroxyphenyl)-5-phenylhydantoin in relation to the incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients. ( Ball, DE; Kamali, F; McLaughlin, WS; Seymour, RA, 1996)
"The duration of the vegetative state was 12 days, 15 days or about 4 months until death and was associated with corresponding stages of generalized ischemic brain damage."1.29Relationship between ischemic damage and concentrations of phenytoin and phenobarbital in the brain cortex of epileptic patients in vegetative state at death. ( Jürgens, U; Lahl, R; May, T; Rambeck, B; Schnabel, R, 1996)
"The seizures were predominantly clonic jerks accompanied by large spikes and slow waves lasting for 30-60s."1.29Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy. ( Satishchandra, P; Shankar, SK; Ullal, GR, 1996)
"Cerebral cavernous angioma (cavernoma) has previously been treated by resection for all presentations when surgically resectable."1.28Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases. ( Churchyard, A; Grainger, K; Khangure, M, 1992)
" Regular 2 weekly follow up for a minimum period of 2 months was done, after altering the drug dosage and bringing plasma level(s) within therapeutic range."1.28"An analysis of epileptic patients nonresponsive to drugs". ( Joshi, MV; Karande, SC; Kshirsagar, NA; Shah, PU, 1992)
" This equation predicts the AUC0-INF produced by a given tracer dose of drug will vary directly with C in drugs with nonlinear pharmacokinetic properties (i."1.28Bioavailability studies of drugs with nonlinear pharmacokinetics: I. Tracer dose AUC varies directly with serum concentration. ( Browne, TR; Evans, BA; Evans, JE; Greenblatt, DJ; Schumacher, GE; Szabo, GK, 1992)
" There was no calcitonin correlation with the anticonvulsant dosage or with the total doses ingested."1.28Long-term influence of anticonvulsant agents on calcitonin, parathyroid hormone and osteocalcin. ( Arias, JA; Cabranes, JA; Rico, H; Varela de Seijas, E, 1992)
" Since praziquantel, the drug used to treat neurocysticercosis, undergoes extensive liver first-pass metabolism, we carried out a prospective study to verify whether there was a decrease in oral bioavailability induced by carbamazepine and phenytoin."1.28Phenytoin and carbamazepine decreased oral bioavailability of praziquantel. ( Bittencourt, PR; Diekmann, HW; Fernandes, AG; Gracia, CM; Jung, W; Martins, R, 1992)
" It could be due to a lower bioavailability (F) of the tested phenytoin preparations and/or a higher volume of distribution (Vd) in Chinese."1.28Comparison on bioequivalence of four phenytoin preparations in patients with multiple-dose treatment. ( Huang, JD; Lai, ML; Tsai, JJ; Yang, YH, 1992)
"A simple and practical graphic method based on Bayesian feedback theory for predicting individual phenytoin dosage was evaluated."1.28A Bayesian graphic method for predicting individual phenytoin dosage schedule. ( Cai, WM; Chen, G; Chu, XM, 1991)
"Only one patient had a complete IgA deficiency."1.28Anti-IgA antibodies in epileptic patients with a low serum IgA concentration. ( Gilhus, NE; Hammarström, L, 1991)
" In order to define the minimal dosage of fentanyl required, the MD was titrated according to increases or decreases in the heart rate and/or mean arterial pressure exceeding 15 per cent of baseline ward values."1.28Anticonvulsant therapy increases fentanyl requirements during anaesthesia for craniotomy. ( Modica, PA; Spitznagel, EL; Tempelhoff, R, 1990)
" Eighty-four patients had been established on treatment with a single anticonvulsant drug (35 carbamazepine (CBZ), 30 sodium valproate (VPA), 19 phenytoin (PHT)) at unaltered dosage for the previous 3 months."1.28Cognitive function in adult epileptic patients established on anticonvulsant monotherapy. ( Brodie, MJ; Butler, E; Gillham, RA; Larkin, JG; Wiedmann, KD; Williams, N, 1990)
"1% seizure control rate), with adverse effects of sedation and intellectual depression."1.28Plasma level distribution, effect and toxicity of antiepileptic drugs among Ethiopian epileptics. ( Abebe, Y; Bekele, G; T'Haimanot, R, 1990)
"Paroxysmal kinesigenic choreoathetosis (PKC) is rare and has only recently been individualized (Kertesz, 1967)."1.28[Paroxysmal kinesigenic choreoathetosis: autonomic disease or reflex epilepsy?]. ( Bricout, JH; Cler, JM; Vercelletto, M; Vercelletto, P, 1990)
"When phenytoin was given with carbamazepine percentage (mean +/- SEM) protein binding was 87."1.28Serum protein binding of antiepileptic drugs in Sri Lankans. ( Joice, PD; Karunanayake, EH; Meijer, JW; Meinardi, H; Peiris, JB, 1990)
" The capability predicting individual phenytoin dosage was assessed by the retrospective analysis of data of 44 patients and the prospective analysis of 15 patients."1.28[Population kinetic program for Michaelis-Menten elimination]. ( Lü, M; Song, JF; Zhou, HW, 1990)
"Phenytoin treatment may impair the validity of the caffeine liver function test."1.28Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism. ( Büchsel, R; Kohl, D; Kreiten, K; Matern, S; Wietholtz, H; Zysset, T, 1989)
" These results support the increased use of dosing aids for PHT that may help clinicians more accurately choose PHT doses and estimate time to steady state."1.28Dosing accuracy of antiepileptic drug regimens as determined by serum concentrations in outpatient epilepsy clinic patients. ( Privitera, MD, 1989)
"The excess numbers of brain cancer were concentrated within 10 years of hospitalization (RR = 20."1.28Cancer among epileptic patients exposed to anticonvulsant drugs. ( Boice, JD; Fraumeni, JF; Jensen, JP; Olsen, JH, 1989)
"25 patients (27."1.28[Epileptic seizures in patients with a cerebrovascular infarction]. ( Burri, H; Karbowski, K; Schäffler, L, 1989)
" We found a noticeable relationship between conduction velocity slowing and daily dosage for CBZ only."1.27Anticonvulsant therapy and its possible consequences on peripheral nervous system: a neurographic study. ( Faedda, MT; Geraldini, C; Sideri, G, 1984)
" Pharmacokinetic interactions between antiepileptic drugs may lead to considerable fluctuation in plasma drug concentration, and monotherapy is often preferable."1.27Pharmacokinetics of antiepileptic drugs. ( Neuvonen, PJ; Tokola, RA, 1983)
"Phenytoin continues to be a very popular drug for most types of seizures, but carbamazepine, used adjunctively until recently, is effective as monotherapy for the control of partial seizures, particularly those of the complex partial variety."1.27Treatment of the nonconvulsive epilepsies. ( Dreifuss, FE, 1983)
"Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given."1.27[Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983)
"Phenobarbital may cause hyperactivity, behavioral problems, sedation, and even dementia; these effects are dose related to some extent."1.27Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy. ( Iivanainen, M; Savolainen, H, 1983)
" However, whereas toxic reactions following phenytoin and carbamazepine are characterised by a rather short duration of exposure before symptoms occur with accompanying clinical features of hypersensitivity, valproate-induced hepatic toxicity exhibits no signs of hypersensitivity and often occurs following prolonged exposure, speaking in favor of a metabolic aberration as the underlying cause."1.27Hepatic toxicity of antiepileptic drugs: a review. ( Bentsen, KD; Gram, L, 1983)
" Significant positive correlations were found between the dosage of CBZ, DPH, PMD and PB and both indices of enzyme induction."1.27A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. ( Hedges, A; Makki, KA; Perucca, E; Richens, A; Ruprah, M; Wilson, JF, 1984)
"Most electrically induced seizures involve forebrain structures, such as the amygdala or frontal cortex, but the following studies characterized a specific anatomic site in the inferior colliculus which generated seizure-like behavior after a single, low current electrical stimulation."1.27Electrically elicited seizures from the inferior colliculus: a potential site for the genesis of epilepsy? ( Breese, GR; Frye, GD; Greenwood, RS; McCown, TJ, 1984)
"The Mullen and Foster method was prospectively applied for individualizing phenytoin dosage in 24 epileptic patients."1.27Clinical application of the Mullen and Foster method for individualizing phenytoin dosage. ( Arnetoli, G; Bartoli, C; Donati-Cori, G; Messori, A; Muscas, GC; Silvano, R; Tendi, E; Valenza, T; Zaccara, G; Zappoli, R, 1984)
" Fifty-one percent of the 53 patients receiving phenytoin were completely controlled at either below or above the 10 to 20 micrograms/ml range, suggesting that individual dosage adjustment is preferably based on clinical judgment rather than numerical limits of published therapeutic ranges."1.27Therapeutic plasma levels of phenytoin, phenobarbital, and carbamazepine: individual variation in relation to seizure frequency and type. ( Haenel, F; Schmidt, D, 1984)
"Phenytoin treatment was associated with further decreases in serum IgA in patients with idiopathic epilepsy (p = 0."1.27Effects of phenytoin on man's immunity. Evaluation of changes in serum immunoglobulins, complement, and antinuclear antibody. ( Bardana, EJ; Craig, S; Davies, GH; Gabourel, JD, 1983)
"Phenytoin was administered intravenously to six adult epileptic patients in doses ranging from 500--1000 mg (equivalent to 5."1.27Acute effects of intravenous phenytoin on the frequency of inter-ictal spikes in man. ( Milligan, N; Oxley, J; Richens, A, 1983)
"Oxazepam was more than 93% bound to serum proteins, but the extent of binding was not significantly different between the two groups."1.27Oxazepam pharmacokinetics in patients with epilepsy treated long-term with phenytoin alone or in combination with phenobarbitone. ( Hawksworth, GM; Khir, AS; Petrie, JC; Scott, AK; Steele, WH, 1983)
"Most patients have quiescent seizure disorders and can manage well on monotherapy."1.27Reduction of polypharmacy for epilepsy in an institution for the retarded. ( Bennett, HS; Dunlop, T; Ziring, P, 1983)
" Due to the increase in tonic-clonic seizures after the initiation of folic acid (1 mg, orally) the sodium phenytoin dosage was increased by 130 mg until control was achieved."1.27Phenytoin and folic acid: individualized drug-drug interaction. ( Berg, MJ; Fischer, LJ; Rivey, MP; Schottelius, DD; Vern, BA, 1983)
"A Bayesian feedback technique for predicting phenytoin dosage was compared to other dosing methods."1.27Predicting phenytoin dosages using Bayesian feedback: a comparison with other methods. ( Ludden, TM; Murphy, MJ; Taylor, JW; Yuen, GJ, 1983)
" In epileptic patients, the plasma PHT concentrations were increased when dosage form was changed from the powder to 99%FG-F."1.27Comparison of bioavailability for phenytoin products prepared by wet granulation in normal subjects and epileptic patients. ( Hosaka, A; Ishikawa, N; Kohda, Y; Nakagawa, F; Nishihara, K; Saitoh, Y; Tamura, Z, 1983)
"Phenytoin treatment prevented the occurrence of convulsive and EEG seizures; however, lipid peroxidation was unaffected (16."1.27Effect of phenytoin and corticosteroids on seizures and lipid peroxidation in experimental posttraumatic epilepsy. ( Triggs, WJ; Willmore, LJ, 1984)
" Predictions are much more complicated when impaired bioavailability exists."1.27Influence of bioavailability on the calculated Michaelis-Menten parameters of phenytoin in children. ( Brand, N; Koren, G; MacLeod, SM, 1984)
" Further, for dogs given phenobarbital, there was a sixfold variation between dosage and achieved serum concentration, whereas dogs given primidone manifested even greater variability between dosage and serum concentration."1.27Serum concentrations and efficacy of phenytoin, phenobarbital, and primidone in canine epilepsy. ( Farnbach, GC, 1984)
"The application of a Bayesian feedback algorithm for phenytoin (PHT) dosing adjustments was modified empirically to take advantage of measurements of plasma unbound PHT concentrations in the estimation of Km values."1.27Use of plasma unbound drug concentrations in adjusting phenytoin doses. ( Bachmann, K; Forney, R; Voeller, K, 1984)
" After the first week of life, drug eliminating mechanisms mature and drug dosage requirements often increase dramatically."1.27Antiepileptic drug utilization in pediatric patients. ( Dodson, WE, 1984)
"Cimetidine can cause significant changes in phenytoin serum levels which may be manifested clinically."1.27Effect of cimetidine on phenytoin serum levels. ( Breland, BD; Jordan, JE; Mishra, SK; Salem, RB, 1983)
"When phenytoin was being reduced, more seizures appeared to originate from the left temporal lobe than from the right."1.27Falsely localizing ictal onsets with depth EEG telemetry during anticonvulsant withdrawal. ( Crandall, PH; Engel, J, 1983)
"Carbamazepine was the most effective to block SEA at concentrations of 1-15 microM."1.27Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices. ( Franceschetti, S; Hamon, B; Heinemann, U; Konnerth, A; Yaari, Y, 1985)
"Phenytoin was associated with the most frequent and highest enzyme elevations in both adult and pediatric patients."1.27Serum 5'-nucleotidase in patients receiving anti-epileptic drugs. ( Fortman, CS; Witte, DL, 1985)
" Frequency and extent of increased activity of gamma-GT were highly related to daily dosage in both preparations."1.27The influence of long-term anticonvulsant therapy with diphenylhydantoin and carbamazepine on serum gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase. ( Aldenhövel, HG, 1988)
" Frequency and extent of increased activity of gamma-GT were highly related to daily dosage in both preparations."1.27[Altered gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase serum activities in long-term anticonvulsive therapy--comparison of diphenylhydantoin and carbamazepine]. ( Aldenhövel, HG, 1988)
" These results show that barbiturates should not be first-choice drugs in patients who have a chronic disease such as epilepsy, and indicate a schedule for barbiturate withdrawal which is safe and independent of hospitalization or monitoring of antiepileptic drug serum concentrations."1.27Barbiturate-refractory epilepsy: safe schedule for therapeutic substitution. ( Bittencourt, PR; Gorz, AM; Silvado, CE, 1986)
"A man with lupus anticoagulant and a prothrombin deficiency was studied before and after cessation of treatment with phenytoin."1.27Concurrent lupus anticoagulants and prothrombin deficiency due to phenytoin use. ( Alperin, JB; Harrison, RL; Kumar, D, 1987)
"In particular, memory deficits, attentional problems, psychomotor slowing and reading and writing difficulties are highlighted, and the impact of the seizures, brain damage, and anticonvulsant drugs on cognitive function noted."1.27[Cognitive effects of antiepileptic drugs]. ( Trimble, R, 1987)
"Phenytoin levels were reduced to 37% of the original values, although the drug was given intravenously."1.27An interaction between cytostatic and anticonvulsant drugs. ( de Voogd-van der Straaten, I; Neef, C, 1988)
" In each patient, the average unbound fraction for a dosing interval increased with increase in sodium valproate dose."1.27Changes in clearance of sodium valproate with changes in dose. ( Bury, RW; Fullinfaw, RO; Kilpatrick, CJ; Moulds, RF, 1987)
" Thus, frequent phenytoin serum concentration determinations or a change in phenytoin dosing rate are probably not necessary after adding phenobarbital."1.27Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics. ( Browne, TR; Evans, BA; Evans, J; Greenblatt, DJ; Mikati, MA; Szabo, GK, 1988)
" In 48% of the patients the drug dosage had to be increased to combat the increased seizure frequency."1.27Serum phenytoin during pregnancy, labor and puerperium. ( Bardy, AH; Hiilesmaa, VK; Teramo, KA, 1987)
"Zonisamide (CI-912) is an experimental antiepileptic drug."1.27Comparative pharmacokinetics of zonisamide (CI-912) in epileptic patients on carbamazepine or phenytoin monotherapy. ( Buchanan, RA; Friel, PN; Levy, RH; McLean, JR; Ojemann, LM; Shastri, RA; Wilensky, AJ, 1986)
" The most common of these causes include malpractice of the dosage build-up in the absence of the clinical effect, polytherapy--not infrequently with drugs of the same chemical group, and insufficient attention to the potentiating drug interaction."1.27[Phenomenon of "paradoxical poisoning" during antiepileptic therapy]. ( Geladze, TSh, 1986)
" Data were excluded for patients who required dosage adjustments because of toxicity or seizures."1.27Effect of influenza vaccine on serum anticonvulsant concentrations. ( Fidone, GS; Jann, MW, 1986)
"Adverse gastrointestinal symptoms from milk may reduce the bioavailability of phenytoin."1.27Effect of simultaneously ingested milk on phenytoin bioavailability. ( Dasheiff, R; Dickinson, L; Dotson, R; Kang, H, 1985)
" The mechanisms responsible for these effects have not been elucidated and possibly include decreased bioavailability or compliance, increased metabolic clearance, or decreased plasma protein binding."1.27Effects of pregnancy on antiepileptic drug utilization. ( Levy, RH; Yerby, MS, 1985)
"According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony."1.27Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985)
"The % of gingival hyperplasia was significantly higher (P less than 0."1.27The effects of phenytoin and sodium valproate on the periodontal health of adult epileptic patients. ( Seymour, RA; Smith, DG; Turnbull, DN, 1985)
"Fifty-nine patients with chronic generalized tonic-clonic or partial seizures refractory to the maximally tolerated daily dosage of single-drug therapy with carbamazepine, phenytoin, phenobarbital, or primidone subsequently received single-drug therapy with another one of these primary anticonvulsant drugs."1.27Alternative single anticonvulsant drug therapy for refractory epilepsy. ( Richter, K; Schmidt, D, 1986)
"Crossover studies, following single oral doses given to 19 healthy volunteers were conducted to compare the bioavailability of three phenytoin preparations: DANTOIN and IDANTOIN (Teva, Israel) and EPANUTIN (Parke-Davis, USA)."1.27Bioavailability of phenytoin: comparison between three preparations. ( Ackerman, Z; Frumerman, I; Garty, M; Kitzes, R; Levy, M; Shved, A, 1985)
" The present stable-isotope methodology offered advantages for the estimation of absolute bioavailability of the oral phenytoin dose in patients, while normal therapy was continued and not withdrawn."1.27Stable-isotope methodology for the bioavailability study of phenytoin during multiple-dosing regimens. ( Baba, S; Kasuya, Y; Mamada, K; Matsukura, M, 1985)
"An animal model of central distal axonopathy following chronic administration of phenytoin is described."1.27Damage of Purkinje cell axons following chronic phenytoin administration: an animal model of distal axonopathy. ( Kirchgässner, N; Volk, B, 1985)
"Epileptiform abnormalities, seizures, or both were detected in 87 patients (17."1.27Ambulatory cassette EEG in clinical practice. ( Bridgers, SL; Ebersole, JS, 1985)
" It is concluded that if, in a given patient, the p-HPPH level corresponds to the value expected from the PHT dose, it can be assumed that compliance and bioavailability are adequate and that the dose does not exceed Vmax."1.27Michaelis-Menten kinetics and the steady-state serum phenytoin/hydroxyphenytoin ratio. ( Bourgeois, BF; Wad, N, 1985)
"Multiple sclerosis is a rare but not exceptional condition in children."1.27Multiple sclerosis in childhood: long term katamnestic investigations. ( Máttyus, A; Veres, E, 1985)
"Patient compliance can be improved by reducing the complexity of drug dosage and by better labeling, packaging and informational exchange."1.26Once-a-day drug regimen for psychiatric patients. ( Hasan, MK; Mooney, RP, 1981)
" A significant correlation was noted between the total dosage and duration of therapy with PHT and the reduction of motor conduction velocity in the posterior tibial nerve."1.26Peripheral neuropathy in children on long-term phenytoin therapy. ( Mochizuki, Y; Motomura, T; Ohkubo, H; Suyehiro, Y; Tanizawa, A, 1981)
" However, no adjustment of phenytoin dosage is warranted, unless clinically indicated, since the free phenytoin levels remain unchanged."1.26Interaction between phenytoin and valproate. ( Beran, RC; Sansom, LN; Schapel, GJ, 1980)
" This would be a manifestation of an independent Phenytoin effect in the high toxic dosage respectively in withdrawal."1.26[EEG in phenytoin intoxication (author's transl)]. ( Mayr, N; Wessely, P, 1981)
"The Michaelis-Menten pharmacokinetics and bioavailability of phenytoin were evaluated in children."1.26Plasma levels and pharmacokinetics of antipileptic drugs in children. ( Miura, H, 1981)
"Ictal and post-ictal confusional states of 24 h or more duration (up to 7-8 days) were noted in 11 patients (14%)."1.26Epileptic seizures in the elderly: II. Diagnostic problems. ( Caird, FI; Godfrey, JW; Roberts, MA, 1982)
"Phenytoin (PHT) binding was also determined for comparison."1.26Diurnal oscillations in plasma protein binding of valproic acid. ( Levy, RH; Ojemann, LM; Patel, IH; Venkataramanan, R; Viswanathan, CT, 1982)
" Reducing the dosage by 19 mg/kg (A to B) decreased VPA plasma levels by 6."1.26Monitoring free valproic acid in epilepsy patients medicated with coanticonvulsants. ( Haidukewych, D; Rodin, EA, 1982)
"Analysis of the recurrence of seizures suggested that the first year of treatment may be crucial in determining the long-term prognosis."1.26Early prognosis of epilepsy. ( Reynolds, EH; Shorvon, SD, 1982)
"Since epilepsy is a long-standing condition lasting for years to decades, short-spanned cross-sectional observations are often misleading."1.26Therapeutic concentration of antiepileptic drugs and the severity of epileptogenesis. ( Kakegawa, N; Seino, M, 1982)
"The prevalence of treated epilepsy in Wellington is 4."1.26Prescribing patterns for epilepsy. ( Johnson, RH; Lambie, DG; Stanaway, L, 1981)
"In the preceding articles, a number of pharmacokinetic concepts have been introduced, and a number of parameters such as plasma half-life, volume of distribution and clearance have been defined."1.26Elementary pharmacokinetics in clinical practice. 3: Practical pharmacokinetic applications. ( Paxton, JW, 1981)
"5%) cases without correlation with the dosage (D in mg/kg)."1.26Comparative study of bioavailabilities of different phenytoin preparations. ( Fukuyama, Y; Goto, T; Kitahara, H, 1982)
"0% at discharge) versus polytherapy; degree of correspondence between recommended and observed dosage regimens (undertreatment being a more common problem than excessive dosing); and reporting of side effects."1.26Quality of care of epilepsy in Italy: multi-hospital survey of diagnosis and treatment of 1104 epileptic patients. ( Beghi, E; Sasanelli, F; Spagnoli, A; Tognoni, G, 1982)
"Among those who showed an IgA deficiency during phenytoin treatment, 14 had the antigen HLA-A2."1.26HLA antigens in epileptic patients with drug-induced immunodeficiency. ( Aarli, JA; Gilhus, NE; Thorsby, E, 1982)
"The bioavailability of phenytoin from rapid release capsule and oral solution formulations relative to that of a slow release capsule formulation was assessed in five patients who had participated in a three-way crossover study performed at steady state."1.26Rapid and slow release phenytoin in epileptic patients at steady state: assessment of relative bioavailability utilizing Michaelis-Menten parameters. ( Gumnit, RJ; Leppik, IE; Pepin, SM; Sawchuk, RJ, 1982)
" The concentration-dependence of the t50% provided the basis for less frequent dosing than one would expect from previous studies of PHT half-life in children with low concentrations."1.26Phenytoin elimination in childhood: effect of concentration-dependent kinetics. ( Dodson, WE, 1980)
" Once two phenytoin serum levels were obtained on two different dosage regimens, a table of future doses and predicted serum levels was calculated and plotted on a graph."1.26Predicting individual phenytoin serum levels of patients seen in a private office practice. ( Gonzalez, MA; Robinson, FC; Warner, RN, 1981)
" Six methods of predicting phenytoin dosage or plasma concentrations--one equation, two nomograms, and three graphs--were compared to actual phenytoin doses and corresponding steady-state serum levels."1.26Clinical utility of six methods of predicting phenytoin doses and plasma concentrations. ( Bruni, J; Murphy, JE; Stewart, RB, 1981)
"Phenytoin half-life was 31."1.26Rapid infusion of phenytoin sodium loading doses. ( Doering, PL; Lee, C; Salem, RB; Wilder, BJ; Yost, RL, 1981)
" The long-term administration of anticonvulsant drugs was monitored by measurement of the serum concentrations of phenytoin and primidone, by seizure anamnesis, and by repeated EEG investigations."1.26Chromosomal investigations in epileptic children during long-term therapy with phenytoin or primidone. ( Esser, KJ; Habedank, M; Kotlarek, F; Mühler, E; Mühler, U, 1981)
"The phenytoin treated children did not differ with respect to the concentrations of IgA in saliva in comparison to the controls."1.26Phenytoin and IgA concentrations in plasma and saliva in epileptic children. ( Falk, O; Modéer, T; Rane, A; Tomson, G, 1981)
"Carbamazepine was given to 152 patients who were receiving multiple drug therapy for uncontrolled seizures."1.26Role of carbamazepine in reducing polypharmacy in epilepsy. ( Maheshwari, MC; Padmini, R, 1981)
"Reversible cerebellar dysfunction is a common manifestation of acute phenytoin toxicity."1.26[Diphenylhydantoin, epilepsy, cerebellar atrophy--histological and electron microscope examinations (author's transl)]. ( Breiden-Arends, C; Gullotta, F, 1981)
" These observations suggest that dosage regimen adjustment of phenytoin based on the averaged Vmax in a given pediatric age group rather than the Km is recommended for a particular patient with inadequate therapeutic control of seizure or toxicity of this drug."1.26Apparent Michaelis-Menten kinetic parameters of phenytoin in pediatric patients. ( Chiba, K; Ishizaki, T; Minagawa, K; Miura, H, 1980)
"Subtherapeutic phenytoin serum levels and loss of seizure control occurred in a 31-year-old man due to decreased bioavailability of oral drug."1.26Reduced seizure control due to spoiled phenytoin capsules. ( Cloyd, JC; Gumnit, RJ; Lesar, TS, 1980)
" Within the therapeutic range, small increments in dosage resulted in large increments in plasma DPH levels, and in the postpartum period high levels of DPH were encountered if the dosage was not reduced."1.26Phenytoin metabolism in pregnancy. ( Emery, MG; Kochenour, NK; Sawchuk, RJ, 1980)
"phenytoin were evaluated."1.26Neuropsychological correlates of anticonvulsants and epileptiform discharges in adult epileptics. ( Dodrill, CB; Wilkus, RJ, 1978)
"Patients with chronic renal failure had low plasma total, but disproportionately high plasma free, drug concentrations indicating impaired protein binding."1.26Salivary phenytoin concentrations in epilepsy and in chronic renal failure. ( Jones, NF; Reynolds, F; Smith, SE; Ziroyanis, PN, 1976)
"Phenytoin dosage was increased to study the effect on the frequency of seizures and the serum concentrations of phenytoin and phenobarbitone."1.26Therapeutic and pharmacokinetic effects of increasing phenytoin in chronic epileptics on multiple drug therapy. ( Johnson, RH; Lambie, DG; Nanda, RN; Shakir, RA, 1976)
"The phenytoin plasma levels were measured in 45 epileptic patients whose only treatment was phenytoin."1.26In vivo interaction of anticonvulsant drugs. The mathematical correlation of plasma levels of anticonvulsant drugs in epileptic patients. ( Abarbanel, J; Eylath, U; Herishanu, Y; Rosenberg, P, 1978)
"Hirsutism was rare in black patients."1.26Effects of diphenylhydantoin in 41 epileptics institutionalized since childhood. ( Herberg, KP, 1977)
"Carbamazepine has recently been introduced for the treatment of generalized tonic-clonic and partial seizures."1.26Recent advances in drug therapy for epilepsy. ( Bruni, J, 1979)
"The mothers of children who developed cancer reported about 25% more illnesses during pregnancy than mothers of healthy control children."1.26Childhood cancer and drugs in pregnancy. ( Draper, GJ; Sanders, BM, 1979)
"Transient hyperkinesia was observed in a 16-year-old epileptic and mentally retarded patient after a single intravenous perfusion of diphenylhydantoin (DPH)."1.26Transient hyperkinesia after a single intravenous perfusion of diphenylhydantoin. Report of a case associated with nontoxic plasma levels of diphenylhydantoin. ( Courjon, J; Dalery, J; de Villard, R; Mauguière, F, 1979)
" The majority of the patients receiving Comital-L tablets showed low serum levels of phenytoin and high serum levels of phenobarbital, while patients treated with the usual daily dosage of Hydantol-F tablets showed adequate therapeutic serum levels of both phenytoin and phenobarbital."1.26Serum levels of phenytoin and phenobarbital in epileptic patients treated with mixture antiepileptic tablets, Comital-L or Hydantol-F. ( Hattori, M; Kazamatsuri, H, 1979)
"The effect of dosage schedules on plasma drug levels was evaluated in two groups of ambulant epileptic patients, whose treatment with diphenylhydantoin (DPH) or phenobarbital (PB) had been simplified by reducing the daily frequency of the dosage regimens."1.26Effectiveness of simplified dosage schedules on the management of ambulant epileptic patients. ( Galli, A; Zaccara, G, 1979)
" The bioavailability of a brand of phenytoin tablets used in Finland was improved in 1976."1.26Effect of increased bioavailability of phenytoin tablets on serum phenytoin concentration in epileptic out-patients. ( Bardy, A; Lehtovaara, R; Neuvonen, PJ, 1979)
"Rhythmic horizontal nystagmus occurred in 7 patients, and only at extreme (40 degrees, 50 degrees) later gaze in 6 of these."1.26Conjugate lateral gaze nystagmus and free phenytoin concentrations in plasma: lack of correlation. ( Downes, H; Olsen, GD; Riker, WK; Smith, B, 1978)
" Monitoring drug levels and electroencephalograms appears to be the method of choice for ensuring safe and effective medication in intractable epilepsy."1.26Electroencephalography and phenytoin toxicity in mentally retarded epileptic patients. ( Helle, EP; Iivanainen, M; Seppäläinen, AM; Viukari, M, 1978)
" Although phenytoin dosage remained relatively constant, plasma phenytoin concentrations during pregnancy were significantly lower than nonpregnant concentrations."1.26Hematologic effects of phenytoin therapy during pregnancy. ( Ramsay, RE; Strauss, RG; Wilder, BJ; Willmore, LJ, 1978)
" Mean saliva phenytoin concentrations did not differ significantly between the two treatment settings and were low largely because of the low mean dosage prescribed."1.26Compliance with anticonvulsant therapy in a hospital clinic and in the community. ( Dollery, CT; Mucklow, JC, 1978)
" When clinically indicated the daily dosage rate was adjusted by 50 mg steps until a serum concentration of 10--20 mg/l was produced."1.26Individual variation in daily dosage requirements for phenytoin sodium in patients with epilepsy. ( Barot, MH; Grant, RH; Maheendran, KK; Mawer, GE; Woodcock, BG, 1978)
" Monitoring plasma concentrations may lead to adaptations of the choice of the drug and of the dosage regimen."1.26Kinetics of drug interactions in the treatment of epilepsy. ( Guelen, P; Knop, H; Schobten, F; van der Kleijn, E; Vree, T; Westenberg, H, 1978)
"The phenytoin therapy was administered as 50 mg chewable Infatabs tablets in a single morning dose of 200 mg."1.26Comparison of serum phenytoin levels in epileptic patients who swallowed their phenytoin tablets with or without previous chewing. ( Bielmann, P; Levac, T, 1978)
"Free phenytoin levels were determined in a group of patients with renal disease treated by hemodialysis or transplantation and in epileptic patients who were otherwise healthy."1.26Correlation between red cell and free plasma phenytoin levels in renal disease. ( Gonda, A; Harvey, CD; Leppik, IE; Sherwin, AL, 1976)
"Gingival hyperplasia was studied in 13 boys with epilepsy living in a state hospital."1.26The effect of oral physiotherapy on dilantin gingival hyperplasia. ( Bibby, BG; Hawes, RR; King, DA, 1976)
"The present study investigated order and temporal spacing interactions of phenytoin and phenobarbital in terms of plasma levels during multiple dosing in monkeys."1.26Interactions of phenytoin and phenobarbital in terms of order and temporal spacing of administration in monkeys. ( Farquhar, JS; Levy, RH; Lockard, JS; Uhlir, V, 1976)
"Two methods for arriving at optimum, individual phenytoin dosage regimens have been evaluated in 12 patients."1.26Individualization of phenytoin dosage regimens. ( Allen, JP; Hoffman, SF; Lalka, D; Ludden, TM; McNay, JL; Nappi, JM; Valutsky, WA; Vicuna, AV; Wallace, JE, 1977)
" Dosage adjustments of DPH in patients were not associated with major changes in the plasma level of unconjugated 4-OH-DPH."1.26Plasma concentrations of 5-(4-hydroxyphenyl)-5-phenylhydantoin in phenytoin-treated patients. ( Garle, M; Hoppel, C; Rane, A; Sjöqvist, F, 1977)
" This indicates that long-term use of phenytoin does not cause a clinically significant state of folate deficiency, unless some other contributing factors are present."1.26Long-term of phenytoin: Effects on whole blood and red cell folate and haematological parameters. ( Knuutila, S; Tammisto, P; Tontti, K; Weber, TH, 1977)
" Intravenous injection of 250 mg phenytoin followed by infusion of 750 mg phenytoin in a mean dosage of 1."1.26[Plasma concentrations after injection or infusion of phenytoin (author's transl)]. ( Schmidt, D; Vogel, A, 1977)
"The possibility of treating status epilepticus by altering the orally administered therapy and leaving parenteral therapy for such cases with progressive impairment of consciousness and/or neuvoregetative disorders was indicated."1.26[Status epilepticus in Lennox-Gastaut syndrome; therapeutic aspects]. ( Lison, MP; Speciali, JG, 1977)
" The incidence increased with the duration of epilepsy and is probably a sequel to long-term administration of phenobarbitone."1.26Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants. ( Critchley, EM; Hayward, HW; Owen, VM; Vakil, SD, 1976)
"Phenytoin is a central anticholinergic agent and a central stimulant of serotonin, and may induce movement disorders as a result of altering these neurotransmitters in the brain."1.26Phenytoin-induced dystonia and choreoathetosis in two retarded epileptic children. ( Chalhub, EG; Devivo, DC; Volpe, JJ, 1976)
"A 28-year-old male of progressive myoclonus epilepsy was reported, who had showed a gradual progression in myoclonus, mental retardation and cerebellar symptoms, and had been treated with a large dosage of diphenylhydantoin."1.26A neuropathological case-study of myoclonus epilepsy. ( Ikeda, K; Ikeda, S; Namba, M; Nishikubo, M; Yoshimura, T, 1976)
" prescribing too low a dosage (the average dose in the adult is 5 mg/kg/day) or lack of cooperation by the patient who either takes the drug irregularly or fails to take it at all."1.26[Determination of plasma phenytoine and treatment of epileptics]. ( De Crousaz, G, 1976)
" Subtherapeutic levels appear to be due to inadequate dosage adjustment."1.26The necessity of drug level monitoring in anticonvulsant drug therapy. ( Bailey, DG; Davis, HL; Johnson, GE; Wilson, TW, 1976)
"In addition to the rate of recurrences, especially oral hygiene, existing bite abnormalities and the degree of mental retardation were considered."1.26[Prospects of surgical treatment in hydantoin-induced gingival hyperplasia]. ( Wörle, M, 1976)
" More common toxic effects were not noted on initial evaluation of the patient."1.26Acute athetosis as a result of phenytoin toxicity in a child. ( Marks, RE; Zinsmeister, S, 1976)
"In two patients, IgA deficiency developed within two to three months of treatment."1.26Drug-induced IgA deficiency in epileptic patients. ( Aarli, JA, 1976)
" Monitoring serum phenytoin levels during chronic therapy is an invaluable therapeutic aid, enabling dosage adjustments to be made in order to achieve a level within the therapeutic range."1.25A study of the pharmacokinetics of phenytoin (diphenylhydantoin) in epileptic patients, and the development of a nomogram for making dose increments. ( Richens, A, 1975)
"Steady-state serum-phenytoin levels were measured in five patients whose phenytoin dosage was changed three or more times for therapeutic purposes."1.25Serum-phenytoin levels in management of epilepsy. ( Dunlop, A; Richens, A, 1975)
"Phenytoin produced a lower serum level than the same dose of its sodium salt."1.25Systematic determination of the serum phenytoin level as an aid in the management of children with epilepsy. ( Gamstorp, I; Lilienberg, G; Norell, E, 1975)
" (3) Use of well-standardized, yet simplified, mental performance tests in combination with changes in the dosage of medication can help in reaching a compromise between acceptable seizure control and avoidance of excessive slowing of mental activity."1.25Effects of different dosages of anticonvulsant drugs on mental performance in patients with chronic epilepsy. ( Dekaban, AS; Lehman, EJ, 1975)
"A tonic-clonic seizure occured after the infusion of 14."1.25Harmful effect of megadoses of vitamins: electroencephalogram abnormalities and seizures induced by intravenous folate in drug-treated epileptics. ( Butterworth, CE; Ch'ien, LT; Krumdieck, CL; Scott, CW, 1975)
"A patient developed disseminated intravascular coagulation with purpura fulminans 1 month after starting Dilantin therapy for a seizure disorder."1.25Dilantin-induced disseminated intravascular coagulation with purpura fulminans. A case report. ( Chassin, MR; Guze, LB; Targan, SR, 1975)
"Phenytoin levels were measured using GLC and magnesium levels by atomic absorption spectrophotometry."1.25Serum magnesium levles in patients treated with phenytoin. ( Blyth, A; Stewart, MJ, 1975)
" All patients were stabilized on diphenylhydantoin alone, and assessment of this drug by gas-liquid chromatography provided a basis for dichotomizing the group into High and Low drug groups, both with and without toxic patients."1.25Diphenylhydantoin serum levels, toxicity, and neuropsychological performance in patients with epilepsy. ( Dodrill, CB, 1975)
"Successful treatment of partial complex seizures (and the epilepsies in general) is a process of management over time and involves several factors."1.25Management of the difficult patient with complex partial seizures. ( Booker, HE, 1975)
"Phenytoin therapy was associated with low immunoglobulin A (21%), failure of antibody response to Salmonella typhi antigen (9%), absence of delayed hypersensitivity (D."1.25Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin). ( Burness, FR; Forbes, IJ; Rischbieth, RH; Sorrell, TC, 1971)
"Blood phenytoin (diphenylhydantoin) concentrations were measured after each dosage change in 12 epileptic patients who were given increasing oral doses of phenytoin."1.25Effect of dosage increments on blood phenytoin concentrations. ( Bochner, F; Eadie, MJ; Hooper, WD; Tyrer, JH, 1972)
"The investigation and treatment of osteomalacia are described in four patients with epilepsy treated with long-term anticonvulsant therapy."1.25Osteomalacia with long-term anticonvulsant therapy in epilepsy. ( Dent, CE; Richens, A; Rowe, DJ; Stamp, TC, 1970)
" Hypocalcaemia was related to high dosage of anticonvulsant drugs, to multiple drug therapy, and to the use of individual anticonvulsant drugs in the following order, with decreasing order of importance: pheneturide, primidone, phenytoin, phenobarbitone."1.25Disturbance of calcium metabolism by anticonvulsant drugs. ( Richens, A; Rowe, DJ, 1970)
" Reduction of phenytoin dosage relieved the intoxication in all patients."1.25Outbreak of anticonvulsant intoxication in an Australian city. ( Eadie, MJ; Hooper, WD; Sutherland, JM; Tyrer, JH, 1970)

Research

Studies (2,565)

TimeframeStudies, this research(%)All Research%
pre-19901608 (62.69)18.7374
1990's402 (15.67)18.2507
2000's254 (9.90)29.6817
2010's238 (9.28)24.3611
2020's63 (2.46)2.80

Authors

AuthorsStudies
Conley, JD1
Kohn, H1
Poupaert, JH1
Vandervorst, D1
Guiot, P1
Moustafa, MM1
Dumont, P1
Flaherty, PT1
Greenwood, TD1
Manheim, AL1
Wolfe, JF1
Anger, T1
Madge, DJ1
Mulla, M1
Riddall, D1
Ragavendran, JV1
Sriram, D1
Kotapati, S1
Stables, J1
Yogeeswari, P1
Alam, O1
Mullick, P1
Verma, SP1
Gilani, SJ1
Khan, SA1
Siddiqui, N2
Ahsan, W1
Azam, F1
El-Gnidi, BA1
Alkskas, IA1
He, X1
Qiu, G2
Yang, J4
Xiao, Y1
Wu, Z1
Hu, X1
Dawidowski, M3
Herold, F2
Chodkowski, A2
Kleps, J2
Szulczyk, P1
Wilczek, M1
Prakash, CR1
Raja, S1
Tripathi, L1
Kumar, P2
Singh, R1
Stables, JP1
McComsey, DF1
Smith-Swintosky, VL1
Parker, MH1
Brenneman, DE1
Malatynska, E1
White, HS3
Klein, BD1
Wilcox, KS1
Milewski, ME1
Herb, M1
Finley, MF1
Liu, Y2
Lubin, ML1
Qin, N1
Reitz, AB1
Maryanoff, BE1
Chońska, J1
Mika, W1
Turło, J1
Kumari, S1
Mishra, CB1
Tiwari, M1
Tanaka, T1
Yajima, N1
Tanitame, A1
Kiyoshi, T1
Miura, Y1
Ayati, A1
Emami, S1
Foroumadi, A1
Shervani, S1
Madden, W1
Gleason, LJ1
Marefi, A1
Srour, M1
John, S1
Canyuk, B1
Anand, TCV1
Sukasem, C1
Pattharachayakul, S1
Ashraf, Z1
Farhat, S1
Rather, MY1
Arabacı Tamer, S1
Koyuncuoğlu, T1
Karagöz Köroğlu, A1
Akakın, D1
Yüksel, M1
Yeğen, BÇ1
Fong, SL1
Lim, KS1
Hariraj, V1
Lee, SC1
Wo, WK1
Ramli, A1
Ho, JH1
Lai, PSM1
Ng, WL1
Nevitt, SJ4
Sudell, M3
Cividini, S1
Marson, AG15
Tudur Smith, C7
Wu, H1
Liu, J1
Qian, F1
Wang, Y2
Guan, S1
Verdez, S1
Thomas, Q1
Garret, P1
Verstuyft, C1
Tisserant, E1
Vitobello, A1
Mau-Them, FT1
Philippe, C1
Bardou, M1
Luu, M1
Bourredjem, A1
Callier, P1
Thauvin-Robinet, C1
Picard, N1
Faivre, L1
Duffourd, Y1
Rajendran, P1
Prabath, I1
Rani, J1
Han, Y1
Zhong, R1
Guo, X1
Cai, M1
Lin, W1
Haris, A2
Bachour, K1
Hopkins, RB1
Tarride, JE1
Keezer, MR1
Panda, SP1
Dhurandhar, Y1
Agrawal, M1
D'Onofrio, G2
Riva, A2
Amadori, E2
Lattanzi, S1
Rose, K1
Verrotti, A1
Striano, P3
Moratalla-Navarro, F1
Moreno, V1
López-Simarro, F1
Barceló, ME1
Aguado, A1
Tomson, T10
Battino, D4
Bromley, R2
Kochen, S1
Meador, KJ5
Pennell, PB5
Thomas, SV2
LoPinto-Khoury, C1
Soto-Insuga, V1
González-Alguacil, E1
García-Peñas, JJ1
Borowicz-Reutt, K2
Banach, M4
Roberti, R1
Vari, MS1
De Giorgis, V1
Cerminara, C1
Specchio, N1
Pietrafusa, N1
Tombini, M1
Assenza, G1
Cappanera, S1
Marini, C1
Rasmini, P1
Veggiotti, P1
Zara, F2
Russo, E2
Dorji, T1
Wangmo, S1
Tenzin, K1
Jamtsho, S1
Pema, D1
Chhetri, B1
Nirola, DK2
Dhakal, GP1
Guan, Q1
Wang, X6
Cao, D1
Li, M1
Luo, Z1
Mao, X1
Zhou, Z1
Li, K1
Guo, Y1
Liu, P1
Chen, Q1
Fan, H1
Sun, T1
Jiang, C1
Liu, X1
Peng, X1
Du, Y2
Xu, Q1
Lin, J1
Gong, J1
Xia, N1
Zhu, Z1
Zheng, R1
Xu, H3
Adab, N1
Bluett-Duncan, M1
Clayton-Smith, J4
Christensen, J1
Edwards, K1
Greenhalgh, J1
Hill, RA1
Jackson, CF1
Khanom, S1
McGinty, RN1
Pulman, J1
Pressler, RM1
Abend, NS1
Auvin, S1
Boylan, G1
Brigo, F2
Cilio, MR1
De Vries, LS1
Elia, M2
Espeche, A1
Hahn, CD1
Inder, T1
Jette, N1
Kakooza-Mwesige, A1
Mader, S1
Mizrahi, EM1
Moshé, SL2
Nagarajan, L1
Noyman, I1
Nunes, ML1
Samia, P1
Shany, E1
Shellhaas, RA1
Subota, A1
Triki, CC1
Tsuchida, T2
Vinayan, KP1
Wilmshurst, JM1
Yozawitz, EG1
Hartmann, H2
Sánchez Fernández, I1
Gaínza-Lein, M1
Amengual-Gual, M1
Barcia Aguilar, C1
Romeu, A1
Torres, A1
Jonas, R1
Douglass, LM1
Abiramalatha, T1
Thanigainathan, S1
Ramaswamy, VV1
Pressler, R1
Shimura, M1
Yamada, H3
Takahashi, H1
Yamada, N3
Go, S1
Yamanaka, G1
Kawashima, H1
Madaan, P1
Rao Pala, N1
Saini, L2
Rawat, C2
Kukal, S1
Kushwaha, S2
Agarwal, R2
Sharma, S4
Srivastava, AK1
Kukreti, R5
Wang, L5
Shi, H1
Kang, Y1
Guofeng, W1
Tiamkao, S1
Suthipinijtham, P1
Kardoost, M1
Hajizadeh-Saffar, E1
Ghorbanian, MT1
Ghezelayagh, Z1
Pooshang Bagheri, K1
Behdani, M1
Habibi-Anbouhi, M1
Cook, R1
Davidson, P1
Martin, R1
Gauci, Z1
Rizzo, C1
Mifsud, S1
Cachia, MJ1
Nasir, BB1
Berha, AB1
Gebrewold, MA1
Yifru, YM1
Engidawork, E1
Woldu, MA1
Sharma, NK1
Kaur, S1
Goel, RK4
Le Coz, J1
Chéron, G1
Nabbout, R1
Patteau, G1
Heilbronner, C1
Hubert, P1
Renolleau, S1
Oualha, M1
Zhao, J1
Ye, Z1
Zhang, Q1
Shan, W1
Wang, Z1
Ye, S1
Zhou, X1
Shao, Z1
Ren, L1
Fox, J1
Ajinkya, S1
Lekoubou, A1
Yokoyama, R1
Hayashi, R1
Umemori, Y1
Arimatsu, A1
Yuki, A1
Abe, R1
Hagemann, A1
Klimpel, D1
Bien, CG1
Brandt, C3
May, TW6
Lagae, L1
Chang, WC1
Hung, SI1
Carleton, BC2
Chung, WH1
Limotai, C2
Phayaph, N1
Pattanasilp, B1
Mokklaew, J1
Limotai, N1
Noguchi, Y1
Takaoka, M1
Hayashi, T4
Tachi, T1
Teramachi, H1
Peters, J1
Vijiaratnam, N1
Angus-Leppan, H1
Yamamoto, Y8
Terada, K1
Araki, Y2
Fukushima, Y2
Imai, K7
Kagawa, Y5
Takahashi, Y8
Soontornpun, A1
Manoyana, N1
Apaijai, N1
Pinyopornpanish, K2
Nadsasarn, A1
Tanprawate, S1
Chattipakorn, N1
Chattipakorn, SC1
Shiratani, Y1
Asai, S1
Usui, N1
Nishida, T1
Yip, VLM1
Pertinez, H1
Meng, X1
Maggs, JL1
Carr, DF1
Park, BK1
Pirmohamed, M2
Łukawski, K1
Czuczwar, SJ4
Hussain, SA1
Heesch, J1
Weng, J1
Rajaraman, RR1
Numis, AL1
Sankar, R1
Gallo, C1
Bonvento, G1
Zagotto, G1
Mucignat-Caretta, C1
Kumar, R2
Arora, R1
Sarangi, SC1
Ganeshan N, S1
Agarwal, A1
Kaleekal, T2
Gupta, YK5
Borowicz-Reutt, KK2
Kaplan, YC1
Demir, O1
Amalakanti, S1
Bhat, UA1
Mylavarapu, MB1
Khandelwal, N2
Sundarachary, NV1
Chakravarty, S1
Kumar, A1
Kathiravan, M1
Kavitha, S1
Shanthi, R1
Kakumoto, M1
Shimokawa, K1
Ueshima, S1
Hira, D1
Okano, T1
Loikas, D1
Linnér, L1
Sundström, A1
Wettermark, B1
von Euler, M1
Asadi-Pooya, AA2
Rostaminejad, M1
Zeraatpisheh, Z1
Mirzaei Damabi, N1
Khosrowshahi, EM1
Jouyban, A1
Farajzadeh, MA1
Tuzen, M1
Afshar Mogaddam, MR1
Nemati, M1
Bertram, EH1
Edelbroek, P1
Goldberg, EM1
Margiotti, K1
Pascolini, G1
Consoli, F1
Guida, V1
Di Bonaventura, C1
Giallonardo, AT1
Pizzuti, A1
De Luca, A1
Hegde, A1
Kaur, A1
Sood, A1
Dhanorkar, M1
Varma, HT1
Singh, G2
Saini, AG1
Gupta, A2
Yek, C1
Hendler, RS1
Newman, JW1
Blunck, JR1
Fields, RK1
Croom, JE1
Weston, J2
Duke, JD1
Ryan, PB1
Suchard, MA1
Hripcsak, G1
Jin, P1
Reich, C1
Schwalm, MS1
Khoma, Y1
Wu, Y1
Shah, NH1
Banda, JM1
Schuemie, MJ1
Dagenais, R1
Wilby, KJ1
Elewa, H1
Ensom, MHH1
Sharma, TK1
Vardey, SK1
Sitaraman, S1
Riaz, M1
Ragsdale, BD1
Rahman, ZU1
Nigam, G1
Methaneethorn, J1
Panomvana, D1
Vachirayonstien, T1
Selioutski, O1
Grzesik, K1
Vasilyeva, ON1
Hilmarsson, Á1
Fessler, AJ1
Liu, L2
Gross, RA1
Kanda, J1
Izumo, N1
Kobayashi, Y3
Onodera, K1
Shimakura, T1
Yamamoto, N1
Takahashi, HE1
Wakabayashi, H2
Popławska, M1
Välitalo, PA1
Wong, YC1
Huntjens, DR1
Proost, JH1
Vermeulen, A1
Krauwinkel, W1
Beukers, MW1
Kokki, H1
Kokki, M1
Danhof, M1
van Hasselt, JGC1
de Lange, ECM1
McCormack, M1
Gui, H1
Ingason, A1
Speed, D1
Wright, GEB1
Zhang, EJ1
Secolin, R1
Yasuda, C1
Kwok, M1
Wolking, S1
Becker, F1
Rau, S1
Avbersek, A1
Heggeli, K1
Leu, C1
Depondt, C3
Sills, GJ4
Auce, P1
Brodie, MJ12
Francis, B1
Johnson, MR1
Koeleman, BPC1
Coppola, A1
Kunz, WS1
Sander, JW5
Lerche, H1
Klein, KM1
Weckhuysen, S1
Krenn, M1
Gudmundsson, LJ1
Stefánsson, K1
Krause, R1
Shear, N1
Ross, CJD1
Delanty, N1
Cendes, F4
Lopes-Cendes, I2
Liao, WP2
O'Brien, TJ2
Sisodiya, SM4
Cherny, S1
Kwan, P3
Baum, L2
Cavalleri, GL2
Shanmugarajah, PD1
Hoggard, N1
Aeschlimann, DP1
Aeschlimann, PC1
Dennis, GJ1
Howell, SJ1
Reuber, M1
Grünewald, RA1
Hadjivassiliou, M1
Shaikh, AS1
Guo, R1
Liao, K1
Ai, CZ1
Yu, X1
Li, W1
Bonizzoni, E1
Craig, J1
Lindhout, D4
Perucca, E15
Sabers, A1
Vajda, F2
Thangaratinam, S1
Marlin, N1
Newton, S1
Weckesser, A1
Bagary, M1
Greenhill, L1
Rikunenko, R1
D'Amico, M1
Rogozińska, E1
Kelso, A1
Hard, K1
Coleman, J1
Moss, N1
Roberts, T1
Middleton, L1
Dodds, J1
Pullen, A1
Eldridge, S1
Pirie, A1
Denny, E1
McCorry, D1
Khan, KS1
Baker, EM1
Thompson, CH2
Hawkins, NA1
Wagnon, JL1
Wengert, ER1
Patel, MK1
George, AL2
Meisler, MH1
Kearney, JA1
Syu, FK1
Pan, HY1
Chuang, PC1
Huang, YS2
Cheng, CY1
Cheng, FJ1
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Lossing, JH1
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König, W1
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Klein, DF1
Greenberg, IM1
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Glickman, I1
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Dawson, M1
Ristić, J1
Abernathy, RS1
Kusano, M1
Nakagawa, S1
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Kelly, WA1
Ward, AA1
Hyman, GA1
Sommers, SC1
Zaninovich, AA1
Farach, H1
Ezrin, C1
Volpé, R1
Shimazono, Y1
Fukuta, T1
Henriksen, PB1
Milichap, JG1
Aymat, F1
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Klinefelter, HF1
Bayley, TA1
Higgins, HP1
Row, VV1
James, W1
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Grace, JB1
Viukari, NM7
Rosenblum, JA1
Shafer, N1
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Mirkin, BL2
Vulliamy, D1
Lunde, PK1
Domzal, T1
Gajkowski, K1
Borkowska, Z1
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Wojakowski, A1
Kristiansen, K1
Kaada, BR1
Henriksen, GF1
Walsh, GO1
Masland, W1
Goldensohn, ES1
Maxwell, JD1
Hunter, J1
Stewart, DA1
Ardeman, S1
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Naess, K1
Grob, PJ1
Herold, GE1
Smethurst, PF1
Genuth, SM1
Klein, L1
Rabinovich, S1
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Soyka, LF1
Harms, D1
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Wallace, JD1
Weintraub, MI1
Rosnagle, R1
Babb, RR1
Eckman, PB1
Ellegaard, J1
Esmann, V1
Cendrowski, W1
Kariks, J1
Perry, SW1
Wood, D1
Birket-Smith, E2
Krogh, E2
Tormey, A1
Toussaint, J1
Allen, RJ1
Pakszys, W1
Huber, Z1
Spalona, M1
Vapaatalo, H1
Lehtinen, L1
De Negri, M1
Luciano, L1
Peltola, O1
Linde, J1
Molholm Hansen, J1
Siersbaek-Nielsen, K1
Fuglsang-Fredriksen, V1
Alberto, P1
Cougn, R1
Maurice, P1
Weber, J1
Preece, J1
Marques-Assis, L1
Wright, F1
Kobayashi, I1
Yamashita, Y1
Yamazaki H OKUDA, S1
Lehtinen, LO1
Armbrecht, EC1
Steere, DW1
Goldstein, J1
Szekeresné Rudas, L1
Flerkóné Bárdos, V1
Ginwalla, TM1
Gomes, GC1
Nayak, RP1
Terner, K1
Tóth, S1
Tollaro, I1
Sabelli, HC1
Yarkut, E1
Turgut, E1
Melin, KA1
Westphal, P1
Hosokowa, K1
Burdette, RD1
Darcey, B1
Rizzo, M1
Garattini, S2
Ritter, R1
Rauchfuhs, P1
Houben, PF1
Hommes, OR1
Knaven, PJ1
Trojaborg, W1
Dent, CE1
Rowe, DJ2
Stamp, TC1
Lunde, KM1
White, PT1
Plott, D1
Norton, J1
Jensen, BN1
Grynderup, V1
Behrman, S1
Okada, M1
Matsui, M1
Kaizu, T1
Abe, F1
Matti, N1
Viukari, A1
McDonald, DF1
Dunne, JF1
Handley, AJ2
Hazleman, BL1
Brennan, R1
Dehejia, H2
Verebely, K2
Averill, DR1
Prineas, RJ1
Choovivathanavanich, P1
Wallace, EM1
Scaglione, PR1
Blumer, D1
Holscher, E1
Walker, BA1
Pedersen, HE1
Allen, CD1
Brennan, RW1
Baughman, FA2
Randinitis, EJ1
Kato, M1
Sotaniemi, E1
Arvela, P1
Hakkarainen, H1
Huhti, E1
Ceballos, R1
Benton, JW1
Laurance, BM1
Gams, RA1
Ausman, JI1
Dashputra, PG1
Khapre, MD1
Stevenson, MM1
Gilbert, EF1
Lascelles, PT1
Kocen, RS1
Kalensky, J1
Herzka, HS1
O'Leary, JA1
Feldman, M1
Switzer, HE1
Hajnsek, F1
Gubarev, N1
Benn, A1
Swan, CH1
Cooke, WT1
Blair, JA1
Matty, AJ1
Smith, ME1
Palkes, H1
Ruskin, HM1
Pritchard, JA1
Scott, DE1
Whalley, PJ1
Jamieson, A1
Reunanen, A1
van Eck, JH1
Harasymiv, I1
Jonas, AD1
Elkes, J1
Turner, WJ1
Rajotte, P1
Jilek, W1
Jilek, L1
Perales, A1
Giard, N1
Bordeleau, JM1
Tétreault, L1
Bancalari, E1
Louis, SS1
Miller, DR1
Hopf, HC1
Gillen, HW2
Pippinger, CE1
Poppe, W1
Krauspe, M1
Patel, H1
Crichton, JU1
Balla, J1
Hansen, E1
Ankerhus, J1
Vedso, S1
Cantu, RC1
Timberlake, WH1
Langgård, H1
Meeuwisse, G1
Tryding, N1
Scholz, B1
Loebe, FM1
Rosen, JA1
Breuer, U1
Lempp, R1
Eisenmann, M1
Friedel, B1
Lindall, AW1
Livingston, HL1
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Segovia, V1
Scott, JE1
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Hirschmann, J1
Höglmeier, H1
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Fukuzawa, H1
Olsesen, OV1
Kramer, MD1
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Guggenheim, P1
Haynes, J2
Molina, P1
Madoz, P1
Kane, FJ1
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Clinical Trials (22)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Precision IFX: Using a Pharmacokinetic Dashboard to Optimize and Individualize Infliximab Dosage for Pediatric Inflammatory Bowel Disease Patients[NCT02624037]189 participants (Actual)Interventional2015-01-31Completed
Pilot Study of Seizure Prophylaxis With Levetiracetam in Aneurysmal Subarachnoid Hemorrhage[NCT01935908]Phase 40 participants (Actual)Interventional2013-05-31Withdrawn (stopped due to no funding)
A Double-blind Trial Comparing the Efficacy, Tolerability and Safety of Monotherapy Topiramate Versus Phenytoin in Subjects With Seizures Indicative of New Onset Epilepsy[NCT00210782]Phase 3262 participants (Actual)Interventional2004-06-30Completed
A Retrospective Study to Evaluate Retention Rate of Topiramate With That of Levetiracetam and Oxcarbazepine in a Long-term Epilepsy Treatment[NCT02098941]2,500 participants (Anticipated)Observational2014-03-31Recruiting
Efficacy and Tolerability of Low vs. Standard Daily Doses of Antiepileptic Drugs in Newly Diagnosed, Previously Untreated Epilepsy (STANDLOW). A Multicenter, Randomized, Single-blind, Parallel-group Trial[NCT03689114]Phase 4374 participants (Anticipated)Interventional2020-01-07Not yet recruiting
A Clinical Pharmacokinetics Comparing Brand and Generic Topiramate in Epilepsy Patients : A Open-label,Randomised, Three-period Crossover Study[NCT02113787]24 participants (Actual)Interventional2014-02-28Completed
Pilot: Levetiracetam to Prevent Post-Traumatic Epilepsy[NCT01463033]Phase 2126 participants (Actual)Interventional2005-04-30Completed
Neurodevelopmental Effects of Antiepileptic Drugs II: the NEAD Study[NCT00021866]331 participants (Actual)Observational2000-09-30Completed
Verapamil as Adjunctive Seizure Therapy for Children and Young Adults With Dravet Syndrome[NCT01607073]Phase 22 participants (Actual)Interventional2012-04-30Completed
The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822]550 participants (Anticipated)Observational2022-02-18Recruiting
A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency[NCT01379469]Phase 220 participants (Actual)Interventional2012-01-31Terminated
Measurement of Risperidone and 9-Hydroxyrisperidone in Plasma and Saliva[NCT00395499]19 participants Observational2001-05-31Completed
Single-dose Potassium Supplementation in ADHD Patients With Lidocaine Ineffectiveness[NCT03563573]Phase 1/Phase 2100 participants (Anticipated)Interventional2018-07-01Enrolling by invitation
Prevalence of Lidocaine Ineffectiveness in Those With Hard-to-treat ADHD[NCT04167189]Early Phase 128 participants (Actual)Interventional2018-01-20Completed
Reliability Testing of a Non-invasive, Pain-free, Taste-based Assessment Approach to Lidocaine Effectiveness[NCT03680885]Early Phase 120 participants (Actual)Interventional2019-08-01Completed
Assessing the Frequency of Lidocaine Ineffectiveness in the General Population vs. Males With ADHD, and Females With ADHD, With or Without PMS[NCT03676725]Early Phase 190 participants (Actual)Interventional2019-08-14Completed
Diaphragmatic Breathing and Heart Rate Variability Training for Improving Hypertension in Fragile X Associated Tremor/Ataxia[NCT03816540]Phase 320 participants (Actual)Interventional2018-05-01Completed
A Prospective Study on the Treatment of Burning Mouth Syndrome With Integration of Traditional Chinese Medicine(TCM) and Western Medicine Based on TCM Syndrome Differentiation[NCT04189367]Phase 380 participants (Anticipated)Interventional2020-06-20Not yet recruiting
The Diagnosis and Management of Patients With Epilepsy: Nationwide, Multicenter Study of Recordings for the Diagnosis and Management of Patients With Epilepsy and Treatment With Levetiracetam in Daily Clinical Practice in Greece[NCT02356731]450 participants (Actual)Observational2015-03-31Completed
An Open Prospective Randomised Long-Term Effectiveness Study, Comparing Best Medical Practice With or Without Adjunctive VNS Therapy in Patients 16 Years and Older With Pharmaco-resistant Partial Epilepsy[NCT00522418]Phase 4122 participants (Actual)Interventional2006-02-28Terminated (stopped due to Insufficient enrollment)
Effect of the Treatment of Vitamin D Deficiency in Drug-resistant Epilepsy[NCT03475225]Phase 3400 participants (Anticipated)Interventional2018-04-30Not yet recruiting
The Role of Hyaluronic Acid in Reconstruction of Interdental Papilla in The Esthetic Zone[NCT02119741]30 participants (Actual)Observational2014-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Post-Traumatic Epilepsy

occurrence of PTE (Post-Traumatic Epilepsy) (NCT01463033)
Timeframe: 2 years

Interventionparticipants (Number)
Levetiracetam6
Observational8

Adverse Events

The 66 subjects with acute head injury with a high risk for developing post-traumatic epilepsy that received levetiracetam 55 mg/kg/day in a b.i.d. were monitored for adverse events through the 30 day treatment period. (NCT01463033)
Timeframe: 30 day treatment period

InterventionEvents (Number)
HeadacheFatigueDrowsinessMemory ImpairmentAmnesiaPainIrritabilityDizzinessAnorexiaEmotional labilityInsomniaCognitive changesAtaxiaDepressionHostilityVertigoNauseaCoughNervousnessParaesthesiaWeight gainHallucinationsOtherDiplopiaSuicidalityPsychosis
Participants28282098151010675767312253152333

Change in Number of Absence Seizures From Week 8 (Baseline) to Week 12

The secondary outcome measure is the change in number of absence seizures from Week 8 (Baseline) to Week 12 (NCT01607073)
Timeframe: Week 8 to Week 12

InterventionAbscence seizures (Number)
Week 8 Baseline165
Week 12 Verapamil 4mg/kg/Day101

Change in Number of General Tonic-clonic Seizures From Week 8 (Baseline) Visit to Week 12 Visit

The primary study endpoint is the change in number of seizures from baseline. Since we only had one participant finish the study, the endpoint was changed to Week 12 visit. Participants were on verapamil for 4 weeks at Week 12. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

InterventionGeneral tonic-clonic seizures (Number)
Week 8 Baseline39
Week 12 Verapamil 4mg/kg/Day14

Change in Number of Myoclonic Seizures From Week 8 (Baseline) to Week 12

The secondary outcome is the change in number of myoclonic seizures between baseline Week 8 visit and Week 12 visit. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

InterventionMyoclonic seizures (Number)
Week 8 Baseline116
Week 12 Verapamil 4mg/kg/Day175

Change From Baseline in Adverse Event Profile (AEP) Score

Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Mean change from baseline AEP Score at 12 months

InterventionUnits on a scale (Mean)
VNS Therapy-6.0
Best Medical Practice-3.2

Change From Baseline in Center for Epidemiologic Studies Depression Scale (CES-D) Score

The Center for Epidemiologic Studies Depression Scale (CES-D) includes 20 items comprising six scales reflecting major dimensions of depression: depressed mood, feelings of guilt and worthlessness, feelings of helplessness and hopelessness, psychomotor retardation, loss of appetite, and sleep disturbance. Possible range of scores is 0 to 60, higher scores indicate more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline CES-D Score at 12 months

InterventionUnits on a Scale (Mean)
VNS Therapy-2.2
Best Medical Practice0.5

Change From Baseline in Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) Score

The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is a 6-item questionnaire validated to screen for depression in people with epilepsy. Scores range from 6 to 24, with higher scores indicating more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline NDDI-E Score at 12 months

InterventionUnits on a Scale (Mean)
VNS Therapy-1.0
Best Medical Practice-0.2

Changes in Anti-epileptic Drugs (AEDs)

Change from baseline in number of AED medications by visit (NCT00522418)
Timeframe: Change from baseline in number of AEDs at 12 months

InterventionNumber of AEDs Taken (Median)
VNS Therapy0
Best Medical Practice0

Mean Change From Beginning of Intervention Clinical Global Impression-Improvement Scale (CGI-I) Score at 12 Months

The Clinical Global Impression scale (CGI-I) is a 7 point scale that requires the clinician to assess how much the patient's illness has improved or worsened relative to a baseline state at the beginning of the intervention Scores range from 1-7: 1, very much improved; 2, much improved; 3, minimally improved; 4, no change; 5, minimally worse; 6, much worse; or 7, very much worse. (NCT00522418)
Timeframe: Mean change from baseline CGI-I Score at 12 months

InterventionUnits on a Scale (Mean)
VNS Therapy-0.8
Best Medical Practice-0.3

Mean Percent Change in Seizure Frequency

Percent change in total seizuires per week from baseline at 12 months (NCT00522418)
Timeframe: Mean percent change from baseline in seizure frequency at 12 months

InterventionPercent Change (Mean)
VNS Therapy-19.1
Best Medical Practice-1.0

Overall Quality of Life in Epilepsy-89 (QOLIE-89) Score in Patients With Baseline & at Least One Post-baseline QOLIE Assessment

QOLIE-89 contains 17 multi-item measures of overall quality of life, emotional well-being, role limitations due to emotional problems, social support, social isolation, energy/fatigue, worry about seizure, medication effects, health discouragement, work/driving/social function, attention/concentration, language, memory, physical function, pain, role limitations due to physical problems, and health perceptions. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. (NCT00522418)
Timeframe: Mean change from baseline QOLIE-89 Overall Score at 12 months

Interventionunits on a scale (Mean)
VNS Therapy5.5
Best Medical Practice1.2

Response Rate

Response Rate is defined as the percent of participants who are responders. A Responder is defined as participants with a reduction of at least 50% or 75% in seizure frequency from baseline to the seizure count evaluation period. (NCT00522418)
Timeframe: Number of Responders at 12 Months

Interventionparticipants (Number)
VNS Therapy10
Best Medical Practice7

Change From Baseline in QOLIE-89 Measures: Subgroup Analysis of Population With Baseline Adverse Event Profile Score < 40

QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months

Interventionunits on a scale (Least Squares Mean)
VNS TherapyBest Medical Practice
Baseline Adverse Event Profile Score < 403.30.5

Change From Baseline in QOLIE-89 Measures: Subgroup Analysis of Population With Baseline Adverse Event Profile Score >= 40

QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months

InterventionUnits on a Scale (Least Squares Mean)
VNS TherapyBest Medical Practice
Baseline Adverse Event Profile Score >= 403.30.7

Reviews

219 reviews available for phenytoin and Aura

ArticleYear
Medicinal chemistry of neuronal voltage-gated sodium channel blockers.
    Journal of medicinal chemistry, 2001, Jan-18, Volume: 44, Issue:2

    Topics: Amyotrophic Lateral Sclerosis; Analgesics; Anticonvulsants; Epilepsy; Humans; Ion Channel Gating; Mo

2001
The importance of triazole scaffold in the development of anticonvulsant agents.
    European journal of medicinal chemistry, 2016, Feb-15, Volume: 109

    Topics: Animals; Anticonvulsants; Drug Discovery; Epilepsy; Humans; Triazoles

2016
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
    The Cochrane database of systematic reviews, 2022, 04-01, Volume: 4

    Topics: Adult; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Humans; Network Meta-Analysis; Phenyto

2022
Cutaneous Hypersensitivity Reaction After Phenytoin Therapy in a Neonate: A Case Report and Review of Literature Elucidating the Potential Pharmacological Plausibility and Preventive Strategies.
    Current drug safety, 2023, Volume: 18, Issue:4

    Topics: Anticonvulsants; Child; Drug Hypersensitivity; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized;

2023
Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022, Volume: 43, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Lamotrigine; Levetiracetam; Network Meta-Analysis;

2022
The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches.
    Mitochondrion, 2022, Volume: 66

    Topics: Anticonvulsants; Carbamazepine; Dementia; Epilepsy; Felbamate; Gabapentin; Humans; Inflammasomes; La

2022
Pharmacokinetic considerations surrounding the use of levetiracetam for seizure prophylaxis in neurocritical care - an overview.
    Expert opinion on drug metabolism & toxicology, 2022, Volume: 18, Issue:9

    Topics: Anticonvulsants; Epilepsy; Humans; Levetiracetam; Phenytoin; Piracetam

2022
Breastfeeding while on treatment with antiseizure medications: a systematic review from the ILAE Women Task Force
    Epileptic disorders : international epilepsy journal with videotape, 2022, 12-01, Volume: 24, Issue:6

    Topics: Breast Feeding; Cannabidiol; Carbamazepine; Child; Clobazam; Clonazepam; Epilepsy; Ethosuximide; Eve

2022
[Paediatric status epilepticus].
    Revista de neurologia, 2022, 10-16, Volume: 75, Issue:8

    Topics: Adult; Anesthetics; Anticonvulsants; Benzodiazepines; Child; Epilepsy; Humans; Ketamine; Lacosamide;

2022
Challenges in epilepsy diagnosis and management in a low-resource setting: An experience from Bhutan.
    Epilepsy research, 2023, Volume: 192

    Topics: Anticonvulsants; Bhutan; Epilepsy; Humans; Phenytoin; Quality of Life; Social Stigma

2023
Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child.
    The Cochrane database of systematic reviews, 2023, 08-29, Volume: 8

    Topics: Child; Cohort Studies; Epilepsy; Female; Humans; Lamotrigine; Male; Phenytoin; Pregnancy; Prenatal E

2023
Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures.
    Epilepsia, 2023, Volume: 64, Issue:10

    Topics: Anticonvulsants; Consensus; Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenytoin; Seizures

2023
Anti-seizure medications for neonates with seizures.
    The Cochrane database of systematic reviews, 2023, 10-24, Volume: 10

    Topics: Adolescent; Adult; Child; Epilepsy; Humans; Infant; Infant, Newborn; Levetiracetam; Phenobarbital; P

2023
An update on CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.
    Expert opinion on drug metabolism & toxicology, 2020, Volume: 16, Issue:8

    Topics: Anticonvulsants; Cytochrome P-450 CYP2C9; Epilepsy; HLA-B Antigens; Humans; Pharmacogenetics; Phenyt

2020
Tics induced by antiepileptic drugs: a pragmatic review.
    Journal of neurology, 2021, Volume: 268, Issue:1

    Topics: Adult; Anticonvulsants; Epilepsy; Humans; Phenytoin; Tic Disorders; Tics

2021
Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications.
    Current neuropharmacology, 2021, Volume: 19, Issue:11

    Topics: Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam

2021
Cosmetic adverse effects of antiseizure medications; A systematic review.
    Seizure, 2021, Volume: 91

    Topics: Animals; Anticonvulsants; Epilepsy; Humans; Phenytoin; Quality of Life; Valproic Acid

2021
Rational Small Molecule Treatment for Genetic Epilepsies.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021, Volume: 18, Issue:3

    Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; Genetic Testing; Genetic Therapy; Humans; NAV1.

2021
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
    The Cochrane database of systematic reviews, 2017, 06-29, Volume: 6

    Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti

2017
Impact of Genetic Polymorphisms on Phenytoin Pharmacokinetics and Clinical Outcomes in the Middle East and North Africa Region.
    Drugs in R&D, 2017, Volume: 17, Issue:3

    Topics: Africa, Northern; Anticonvulsants; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Epilepsy; Geno

2017
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
    The Cochrane database of systematic reviews, 2017, 12-15, Volume: 12

    Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti

2017
Genetic variation in
    Neurology, 2018, 01-23, Volume: 90, Issue:4

    Topics: Anticonvulsants; Apolipoproteins; Asian People; Carbamazepine; Case-Control Studies; Complement Fact

2018
The association between CYP2C9/2C19 polymorphisms and phenytoin maintenance doses in Asian epileptic patients: A systematic review and meta-analysis
.
    International journal of clinical pharmacology and therapeutics, 2018, Volume: 56, Issue:7

    Topics: Anticonvulsants; Asian People; Chi-Square Distribution; Cytochrome P-450 CYP2C19; Cytochrome P-450 C

2018
Choice of therapeutic anti-seizure medication in patients with brain tumour.
    JPMA. The Journal of the Pakistan Medical Association, 2019, Volume: 69, Issue:3

    Topics: Anticonvulsants; Brain Neoplasms; Drug Therapy, Combination; Epilepsy; Gabapentin; Glioma; Humans; L

2019
Effects of phenytoin on serum levels of homocysteine, vitamin B12, folate in patients with epilepsy: A systematic review and meta-analysis (PRISMA-compliant article).
    Medicine, 2019, Volume: 98, Issue:12

    Topics: Anticonvulsants; Epilepsy; Folic Acid; Homocysteine; Humans; Phenytoin; Research Design; Vitamin B 1

2019
Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review.
    The Cochrane database of systematic reviews, 2019, 07-18, Volume: 7

    Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Humans; Phenytoin; Randomized Controlled Trials as

2019
Seizures and intracranial hemorrhage.
    Obstetrics and gynecology clinics of North America, 2013, Volume: 40, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Congenital Abnormalities; Eclampsia; Epilepsy; Female; Folic Acid; H

2013
Oxcarbazepine versus phenytoin monotherapy for epilepsy.
    The Cochrane database of systematic reviews, 2013, May-31, Issue:5

    Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Humans; Induction Chemotherapy; Oxcar

2013
Periodontal growth in areas of vascular malformation in patients with Sturge-Weber syndrome: a management protocol.
    The Journal of craniofacial surgery, 2014, Volume: 25, Issue:1

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Gingiva; Gingival Hyperplasia; Gingivectomy; Humans; Male;

2014
Sulthiame monotherapy for epilepsy.
    The Cochrane database of systematic reviews, 2014, Mar-09, Issue:3

    Topics: Adult; Anticonvulsants; Child; Child, Preschool; Early Termination of Clinical Trials; Epilepsy; Epi

2014
WITHDRAWN: Traditional Chinese medicine for epilepsy.
    The Cochrane database of systematic reviews, 2014, Mar-11, Issue:3

    Topics: Anticonvulsants; Drugs, Chinese Herbal; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medicine, Chinese

2014
HLA-B*1502 increases the risk of phenytoin or lamotrigine induced Stevens-Johnson Syndrome/toxic epidermal necrolysis: evidence from a meta-analysis of nine case-control studies.
    Drug research, 2015, Volume: 65, Issue:2

    Topics: Anticonvulsants; Case-Control Studies; Epilepsy; Genetic Predisposition to Disease; HLA-B15 Antigen;

2015
Burns and epilepsy--review and case report.
    Burns : journal of the International Society for Burn Injuries, 2015, Volume: 41, Issue:2

    Topics: Adult; Anticonvulsants; Burns; Epilepsy; Female; Humans; Phenytoin

2015
CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.
    Expert opinion on drug metabolism & toxicology, 2015, Volume: 11, Issue:8

    Topics: Anticonvulsants; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Dose-Response Relationship, Drug

2015
Pharmacological treatments for preventing epilepsy following traumatic head injury.
    The Cochrane database of systematic reviews, 2015, Aug-10, Issue:8

    Topics: Adult; Anticonvulsants; Carbamazepine; Cause of Death; Child; Craniocerebral Trauma; Epilepsy; Human

2015
Antiepileptic drugs for seizure control in people with neurocysticercosis.
    The Cochrane database of systematic reviews, 2015, Oct-12, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Brain Diseases; Carbamazepine; Child; Child, Preschool; Epilepsy

2015
Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats.
    Neuropeptides, 2016, Volume: 56

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Disease Models, Animal; Electroencephal

2016
Antiepileptic Drugs.
    Continuum (Minneapolis, Minn.), 2016, Volume: 22, Issue:1 Epilepsy

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; O

2016
[Preconceptional and perinatal challenges of pregnancy in women with epilepsy].
    Orvosi hetilap, 2016, Apr-10, Volume: 157, Issue:15

    Topics: Adult; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epileps

2016
Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action.
    Journal of neurology, 2017, Volume: 264, Issue:8

    Topics: Animals; Anticonvulsants; Antineoplastic Agents; Breast Neoplasms; Drug Discovery; Epilepsy; History

2017
Traditional Chinese medicine for epilepsy.
    The Cochrane database of systematic reviews, 2009, Jul-08, Issue:3

    Topics: Anticonvulsants; Drugs, Chinese Herbal; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medicine, Chinese

2009
Arrhythmia, heart rate variability, and antiepileptic drugs.
    Epilepsia, 1997, Volume: 38, Issue:11 Suppl

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Elect

1997
New antiepileptic drugs: molecular targets.
    Central nervous system agents in medicinal chemistry, 2009, Volume: 9, Issue:2

    Topics: Action Potentials; Animals; Anticonvulsants; Barbiturates; Carbamazepine; Clinical Trials as Topic;

2009
Empact syndrome: a case report and review of the literature.
    International journal of dermatology, 2010, Volume: 49, Issue:8

    Topics: Anticonvulsants; Brain Neoplasms; Drug Eruptions; Epilepsy; Humans; Lung Neoplasms; Male; Middle Age

2010
Question 2 Should phenytoin and carbamazepine be avoided in Asian populations with the HLA-B*1502 positive genetic variant?
    Archives of disease in childhood, 2011, Volume: 96, Issue:1

    Topics: Anticonvulsants; Asian People; Carbamazepine; Child; Contraindications; Drug Eruptions; Epilepsy; Ev

2011
Epilepsy (generalised).
    BMJ clinical evidence, 2010, Jun-22, Volume: 2010

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Epilepsy, Generalized; Humans; Incidence; Phenytoin; Remis

2010
Epilepsy (partial).
    BMJ clinical evidence, 2010, Jun-28, Volume: 2010

    Topics: Anticonvulsants; Clinical Trials as Topic; Cost-Benefit Analysis; Epilepsies, Partial; Epilepsy; Hum

2010
Epilepsy (partial).
    BMJ clinical evidence, 2011, May-06, Volume: 2011

    Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy; Humans; Phenytoin; Vigabatrin

2011
Pharmacogenetics of the antiepileptic drugs phenytoin and lamotrigine.
    Drug metabolism and drug interactions, 2011, Volume: 26, Issue:1

    Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; E

2011
Side effects of phenobarbital in epilepsy: a systematic review.
    Epileptic disorders : international epilepsy journal with videotape, 2011, Volume: 13, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Cohort Studies; Cross-Over Studies; Data

2011
Management of acute seizure and status epilepticus in pediatric emergency.
    Indian journal of pediatrics, 2012, Volume: 79, Issue:4

    Topics: Anesthesia, Intravenous; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Combined Modalit

2012
The effects of antiepileptic drugs on oral health.
    Journal (Canadian Dental Association), 2011, Volume: 77

    Topics: Alveolar Bone Loss; Anticonvulsants; Carbamazepine; Epilepsy; Gingival Hyperplasia; Humans; Oral Hea

2011
Epilepsy (generalised).
    BMJ clinical evidence, 2012, Feb-20, Volume: 2012

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Epilepsy, Generalized; Humans; Incidence; Phenytoin; Remis

2012
Efficacy and safety of innovator versus generic drugs in patients with epilepsy: a systematic review.
    Pharmacotherapy, 2012, Volume: 32, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Data Interpretation, Statistical; Dose-Response Relationship, Drug;

2012
New antiepileptic drug therapies.
    Neurologic clinics, 2002, Volume: 20, Issue:4

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Dioxolanes; Ep

2002
Epilepsy and pregnancy: maternal and fetal effects of phenytoin.
    Critical care nurse, 2003, Volume: 23, Issue:2

    Topics: Adolescent; Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications

2003
[Clinical guidelines for treatment of epilepsy in children].
    No to hattatsu = Brain and development, 2004, Volume: 36, Issue:2

    Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Cosyntropin; Electroencephalography; Epileps

2004
Phenobarbital for the treatment of epilepsy in the 21st century: a critical review.
    Epilepsia, 2004, Volume: 45, Issue:9

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Cost-Benefit Analysis; Developing Countries; Drug Costs; E

2004
Impact of phenytoin therapy on the skin and skin disease.
    Expert opinion on drug safety, 2004, Volume: 3, Issue:6

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Child; Connective Tissue Diseases; Drug Eruptio

2004
Cancer risk in people with epilepsy: the role of antiepileptic drugs.
    Brain : a journal of neurology, 2005, Volume: 128, Issue:Pt 1

    Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Neoplasms; Phenobarbital; Phenytoin; Rats

2005
Therapeutic drug monitoring of old and newer anti-epileptic drugs.
    Clinical chemistry and laboratory medicine, 2004, Volume: 42, Issue:11

    Topics: Anticonvulsants; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Drug Monitoring; Epilepsy;

2004
Pharmacological and clinical aspects of antiepileptic drug use in the elderly.
    Epilepsy research, 2006, Volume: 68 Suppl 1

    Topics: Aged; Aging; Anticonvulsants; Epilepsy; Homes for the Aged; Humans; Nursing Homes; Phenytoin; Polyph

2006
Oxcarbazepine versus phenytoin monotherapy for epilepsy.
    The Cochrane database of systematic reviews, 2006, Apr-19, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Humans; Oxcarbazepine; Phenytoin; Ran

2006
[Epilepsy and male sexual dysfunction: etiology, diagnosis and therapy].
    Ideggyogyaszati szemle, 2006, May-20, Volume: 59, Issue:5-6

    Topics: Androgens; Anticonvulsants; Bromocriptine; Carbamazepine; Cognition; Enzyme Induction; Epilepsy; Gon

2006
[Anticonvulsants treatment of psychiatric disorder in elderly patients].
    Przeglad lekarski, 2006, Volume: 63, Issue:7

    Topics: Aged; Anticonvulsants; Anxiety Disorders; Bipolar Disorder; Carbamazepine; Epilepsy; Humans; Mental

2006
Therapeutic monitoring of antiepileptic drugs for epilepsy.
    The Cochrane database of systematic reviews, 2007, Jan-24, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; Phenobarbital; Phenytoin; Primido

2007
Drug transporters in the epileptic brain.
    Epilepsia, 2007, Volume: 48 Suppl 1

    Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain

2007
Treatment of convulsive status epilepticus in infants and young children in Japan.
    Acta neurologica Scandinavica. Supplementum, 2007, Volume: 186

    Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Child; Child, Preschool; Epilepsy; Humans; Infant; I

2007
Antiepileptic drugs as human teratogens.
    Expert opinion on drug safety, 2008, Volume: 7, Issue:2

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital

2008
Clinical pharmacology of parenteral use of antiepileptic drugs.
    Epilepsia, 2007, Volume: 48 Suppl 8

    Topics: Anticonvulsants; Epilepsy; Humans; Infusions, Intravenous; Injections, Intravenous; Levetiracetam; P

2007
Phenytoin: relationship between cerebellar function and epileptic discharges.
    Advances in neurology, 1980, Volume: 27

    Topics: Animals; Cerebellum; Electric Stimulation; Epilepsy; Humans; Neurotransmitter Agents; Phenytoin

1980
Psychopharmacological aspects of antiepileptic treatment.
    Progress in neurobiology, 1980, Volume: 15, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Electroencephalography; Epilepsy; Ethosux

1980
[Advance and clinic of antiepileptic drugs (author's transl)].
    Sheng li ke xue jin zhan [Progress in physiology], 1981, Volume: 12, Issue:3

    Topics: Animals; Anticonvulsants; Benzodiazepines; Brain; Carbamazepine; Epilepsy; Humans; Ion Channels; Mic

1981
Phenytoin revisited.
    Clinical therapeutics, 1984, Volume: 6, Issue:5

    Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Cerebrovascular Disorders; Clinical Trials as Topic;

1984
Diagnosis and treatment of epilepsy.
    Hospital & community psychiatry, 1983, Volume: 34, Issue:6

    Topics: Automatism; Benzodiazepines; Carbamazepine; Electroencephalography; Epilepsies, Partial; Epilepsy; E

1983
Final adult height of patients with epilepsy.
    Developmental medicine and child neurology, 1983, Volume: 25, Issue:5

    Topics: Adolescent; Adult; Age Factors; Body Height; Epilepsies, Partial; Epilepsy; Epilepsy, Tonic-Clonic;

1983
Mental effects of antiepileptic medication: a review.
    Epilepsia, 1983, Volume: 24 Suppl 2

    Topics: Adolescent; Adult; Anticonvulsants; Attention; Barbiturates; Brain Chemistry; Carbamazepine; Child;

1983
Clinical pharmacokinetics of sodium valproate, carbamazepine and phenytoin. Level-dose ration and interactions.
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1984, Feb-07, Volume: 73, Issue:6

    Topics: Carbamazepine; Drug Interactions; Epilepsy; Humans; Intestinal Absorption; Kinetics; Phenytoin; Valp

1984
Pharmacological principles in the long-term treatment of epilepsy.
    European neurology, 1981, Volume: 20, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Kinetics; Long

1981
The epileptic mother and her child.
    Epilepsia, 1982, Volume: 23, Issue:1

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Fetal

1982
Use of antiepileptic drugs in the presence of liver and kidney diseases: a review.
    Epilepsia, 1982, Volume: 23 Suppl 1

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Half-Life; Humans; Kidney Diseases; Kinetics; Liver Diseas

1982
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry.
    Clinical chemistry, 1980, Volume: 26, Issue:6

    Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; E

1980
Seizure disorders.
    The Veterinary clinics of North America. Small animal practice, 1980, Volume: 10, Issue:1

    Topics: Animals; Cat Diseases; Cats; Diagnosis, Differential; Diazepam; Dog Diseases; Dogs; Epilepsy; Mephob

1980
Status epilepticus.
    Neurologic clinics, 1995, Volume: 13, Issue:3

    Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Brain; Electroencephalography; Epilepsy; Female; Hum

1995
New anticonvulsant drugs. Focus on flunarizine, fosphenytoin, midazolam and stiripentol.
    Drugs, 1994, Volume: 48, Issue:2

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; Cross-Over Studies; Dioxolanes

1994
Antiepileptic drugs and mechanisms of epileptogenesis. A review.
    Italian journal of neurological sciences, 1995, Volume: 16, Issue:4

    Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Epilepsy; Phenobarbital; Phenytoin; Receptors, GABA

1995
Phenytoin and carbamazepine: differential effects on cognitive function.
    Seizure, 1995, Volume: 4, Issue:2

    Topics: Carbamazepine; Clinical Trials as Topic; Cognition; Drug Therapy, Combination; Epilepsy; Humans; Neu

1995
Biochemical and molecular teratology of fetal hydantoin syndrome.
    Neurologic clinics, 1994, Volume: 12, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Disease Models, Animal; Epilepsy; Face; Female; Fet

1994
Pregnancy, teratogenesis, and epilepsy.
    Neurologic clinics, 1994, Volume: 12, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newb

1994
The development of epilepsy in the paediatric brain.
    Seizure, 1994, Volume: 3, Issue:4

    Topics: Age Factors; Animals; Baclofen; Child; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Humans; Infan

1994
Standard approach to antiepileptic drug treatment in the United Kingdom.
    Epilepsia, 1994, Volume: 35 Suppl 4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Administration Schedule; Drug Monitor

1994
Pharmacologic intervention and treatment of childhood seizure disorders: relative efficacy and safety of antiepileptic drugs.
    Epilepsia, 1994, Volume: 35 Suppl 2

    Topics: Animals; Anticonvulsants; Carbamazepine; Child; Clinical Trials as Topic; Drug Administration Schedu

1994
[Diagnosis and therapy of epilepsy and myoclonus].
    Nihon rinsho. Japanese journal of clinical medicine, 1993, Volume: 51, Issue:11

    Topics: Acetates; Amines; Cerebral Cortex; Cyclohexanecarboxylic Acids; Electrophysiology; Epilepsy; Gabapen

1993
Drug interaction profile of topiramate.
    Epilepsia, 1996, Volume: 37 Suppl 2

    Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epile

1996
Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment.
    Epilepsia, 1996, Volume: 37 Suppl 1

    Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Benzodiazepines; Central Nervous System Disea

1996
Fosphenytoin use in children.
    Neurology, 1996, Volume: 46, Issue:6 Suppl 1

    Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Humans; Infant, Newborn; Phenytoin

1996
Intravenous administration of fosphenytoin: options for the management of seizures.
    Neurology, 1996, Volume: 46, Issue:6 Suppl 1

    Topics: Anticonvulsants; Epilepsy; Humans; Infusions, Parenteral; Phenytoin; Status Epilepticus

1996
Emergency treatment of status epilepticus.
    Neurology, 1996, Volume: 46, Issue:6 Suppl 1

    Topics: Anticonvulsants; Emergencies; Epilepsy; Humans; Phenytoin

1996
Intramuscular use of fosphenytoin: an overview.
    Neurology, 1996, Volume: 46, Issue:6 Suppl 1

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Injections, Intramuscular; Male; Phenytoin

1996
Pharmacology and pharmacokinetics of fosphenytoin.
    Neurology, 1996, Volume: 46, Issue:6 Suppl 1

    Topics: Animals; Anticonvulsants; Epilepsy; Humans; Phenytoin

1996
Parenteral antiepileptic/anticonvulsant drugs.
    Neurology, 1996, Volume: 46, Issue:6 Suppl 1

    Topics: Anticonvulsants; Epilepsy; Humans; Infusions, Parenteral; Phenobarbital; Phenytoin

1996
Antiepileptic drug mechanisms of action.
    Epilepsia, 1995, Volume: 36 Suppl 2

    Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Calciu

1995
Adverse effects of established and new antiepileptic drugs: an attempted comparison.
    Pharmacology & therapeutics, 1995, Volume: 68, Issue:3

    Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; gamma-Aminobutyric Acid; Gastrointestinal Disease

1995
Optimisation of antiepileptic drug therapy. The importance of serum drug concentration monitoring.
    Clinical pharmacokinetics, 1996, Volume: 31, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; Phenobarbital; Phenytoin

1996
Safety of fosphenytoin sodium.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1996, Nov-15, Volume: 53, Issue:22

    Topics: Adult; Anticonvulsants; Biological Availability; Chemistry, Pharmaceutical; Drug Interactions; Epile

1996
Antiepileptic drugs--current use.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1996, Volume: 23, Issue:4 Suppl 2

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenytoin; Valproic Acid

1996
Basis of the antiseizure action of phenytoin.
    General pharmacology, 1996, Volume: 27, Issue:7

    Topics: Animals; Anticonvulsants; Central Nervous System; Epilepsy; Humans; Neurons; Phenytoin; Sodium Chann

1996
[Antiepileptic drugs: mechanism of action].
    Neurologia (Barcelona, Spain), 1996, Volume: 11 Suppl 4

    Topics: Anticonvulsants; Barbiturates; Carbamazepine; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; H

1996
Established antiepileptic drugs.
    Bailliere's clinical neurology, 1996, Volume: 5, Issue:4

    Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Epilepsy; Humans; Phenytoin; Succinim

1996
New drug therapy for acute seizure management.
    Seminars in pediatric neurology, 1997, Volume: 4, Issue:1

    Topics: Acute Disease; Anticonvulsants; Child; Diazepam; Epilepsy; Humans; Phenytoin; Prodrugs; Seizures; Va

1997
Pharmacologic and dietary therapies in epilepsy: conventional treatments and recent advances.
    Southern medical journal, 1997, Volume: 90, Issue:5

    Topics: Acetates; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epil

1997
Recent advancements in epilepsy.
    Surgical neurology, 1997, Volume: 48, Issue:2

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabap

1997
Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation.
    Clinical pharmacokinetics, 1997, Volume: 33, Issue:3

    Topics: Anticonvulsants; Area Under Curve; Carbamazepine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-4

1997
Advances in the medical treatment of epilepsy.
    Annual review of medicine, 1998, Volume: 49

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Diazepam; Drug Approv

1998
Do antiepileptic drugs exacerbate seizures?
    Epilepsia, 1998, Volume: 39, Issue:1

    Topics: Acute Disease; Anticonvulsants; Epilepsy; Humans; Phenytoin; Seizures

1998
Antiepileptic drug-induced worsening of seizures in children.
    Epilepsia, 1998, Volume: 39 Suppl 3

    Topics: Acute Disease; Anticonvulsants; Child; Drug Overdose; Drug-Related Side Effects and Adverse Reaction

1998
Oral problems and genetic aspects of individuals with epilepsy.
    Periodontology 2000, 1994, Volume: 6

    Topics: Dental Care for Chronically Ill; Dental Plaque; Dental Prophylaxis; Epilepsy; Fibroblasts; Gingival

1994
Features and management of poisoning with modern drugs used to treat epilepsy.
    QJM : monthly journal of the Association of Physicians, 1998, Volume: 91, Issue:5

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenytoin; Valproic Acid

1998
Pediatric use of intravenous and intramuscular phenytoin: lessons learned.
    Journal of child neurology, 1998, Volume: 13 Suppl 1

    Topics: Anticonvulsants; Chemistry, Pharmaceutical; Child; Child, Preschool; Dose-Response Relationship, Dru

1998
Clinical experience with fosphenytoin in adults: pharmacokinetics, safety, and efficacy.
    Journal of child neurology, 1998, Volume: 13 Suppl 1

    Topics: Adult; Anticonvulsants; Chemistry, Pharmaceutical; Drug Administration Schedule; Epilepsy; Humans; I

1998
Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs.
    Epilepsia, 1998, Volume: 39 Suppl 7

    Topics: Anticonvulsants; Biotransformation; Carbamazepine; Cytochrome P-450 Enzyme System; Drug Hypersensiti

1998
Antiepileptic drug hypersensitivity syndrome.
    Epilepsia, 1998, Volume: 39 Suppl 7

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross Reactions; Diagnosis, Differential; D

1998
Pharmacokinetics of antiepileptic drugs.
    Neurology, 1998, Volume: 51, Issue:5 Suppl 4

    Topics: Adult; Anticonvulsants; Child; Epilepsy; Half-Life; Humans; Kidney; Metabolic Clearance Rate; Phenyt

1998
Phenytoin: effective but insidious therapy for epilepsy in people with intellectual disability.
    Journal of intellectual disability research : JIDR, 1998, Volume: 42 Suppl 1

    Topics: Anticonvulsants; Brain; Dose-Response Relationship, Drug; Epilepsy; Humans; Intellectual Disability;

1998
Dilantin jeopardy: avoiding the dangers of phenytoin.
    Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses, 1998, Volume: 7, Issue:6

    Topics: Adult; Anticonvulsants; Drug Interactions; Drug Monitoring; Epilepsy; Humans; Male; Phenytoin

1998
Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy.
    Journal of clinical pharmacology, 1999, Volume: 39, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Clinical Trials, Phase II as Topic; Clinical Tria

1999
Monostars: an aid to choosing an antiepileptic drug as monotherapy.
    Epilepsia, 1999, Volume: 40 Suppl 6

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Administration S

1999
Oxcarbazepine.
    Epilepsia, 1999, Volume: 40 Suppl 5

    Topics: Adult; Animals; Anticonvulsants; Biological Availability; Biotransformation; Carbamazepine; Controll

1999
Is generic prescribing acceptable in epilepsy?
    Drug safety, 2000, Volume: 23, Issue:3

    Topics: Anticonvulsants; Area Under Curve; Biological Availability; Carbamazepine; Chemistry, Pharmaceutical

2000
Reduction of severe gingival overgrowth in a kidney transplant patient by replacing cyclosporin A with tacrolimus.
    Journal of periodontology, 2000, Volume: 71, Issue:10

    Topics: Anticonvulsants; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Epilepsy; Female; Gingival

2000
Therapeutic safety monitoring: what to look for and when to look for it.
    Epilepsia, 2000, Volume: 41 Suppl 8

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Monitoring; Epil

2000
New antiepileptic drugs and preparations.
    Emergency medicine clinics of North America, 2000, Volume: 18, Issue:4

    Topics: Acetates; Administration, Rectal; Age Factors; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids;

2000
Gender-specific prescribing: medications and the menstrual cycle.
    The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia, 1998, Volume: 1, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Asthma; Bronchodilator Agents; Epilepsy; Female; Humans; Menstru

1998
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
    Epilepsia, 2001, Volume: 42, Issue:4

    Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic;

2001
Treatment of epilepsy in 3 specialized populations.
    The American journal of managed care, 2001, Volume: 7, Issue:7 Suppl

    Topics: Age Factors; Aged; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Epilepsy; Female; Human

2001
Animal models of drug-resistant epilepsy.
    Novartis Foundation symposium, 2002, Volume: 243

    Topics: Amygdala; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain;

2002
Carbamazepine versus phenytoin monotherapy for epilepsy.
    The Cochrane database of systematic reviews, 2002, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenytoin; Randomized Controlled Trials as Topic

2002
[Diphenylhydantoin. Metabolism, pharmacokinetics, interactions and side effects].
    Schweizerische medizinische Wochenschrift, 1976, Jun-05, Volume: 106, Issue:23

    Topics: Anti-Anxiety Agents; Benzodiazepines; Bone and Bones; Bone Marrow; Carbamazepine; Cerebellar Disease

1976
[Pharmacotherapy of epilepsy. II].
    Die Medizinische Welt, 1978, Jun-02, Volume: 29, Issue:22

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Carbamazepin

1978
[Long-term anticonvulsant therapy (author's transl)].
    Der Nervenarzt, 1978, Volume: 49, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Clonazepam; Epilepsy; Ethosuximide; Humans; Long-Te

1978
Valproic acid. Review of a new antiepileptic drug.
    Archives of neurology, 1979, Volume: 36, Issue:7

    Topics: Adolescent; Adult; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Electroencepha

1979
The pharmacological treatment of epilepsy.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1979, Oct-06, Volume: 56, Issue:15

    Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies,

1979
Epilepsy and schizophrenia: a neurochemical bridge.
    Journal of neural transmission, 1977, Volume: 40, Issue:2

    Topics: Amphetamine; Anticonvulsants; Brain; Butyrophenones; Disulfiram; Dopamine; Dopamine beta-Hydroxylase

1977
The medical treatment of epilepsy: initiation of drug therapy.
    Pediatric annals, 1979, Volume: 8, Issue:4

    Topics: Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Bromides; Carbamazepine; Child; Child, Pre

1979
Conceptual issues in the use of drugs for the treatment of aggression in man.
    The Journal of nervous and mental disease, 1975, Volume: 160, Issue:2-1

    Topics: Adolescent; Adult; Aggression; Alcoholic Intoxication; Animals; Anti-Anxiety Agents; Anticonvulsants

1975
Behavioural effects of anti-epileptic drugs.
    Developmental medicine and child neurology, 1975, Volume: 17, Issue:5

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Confusion; Disorders of Excess

1975
[Treatment of epileptics with the aid of antiepileptic drug blood level determinations (author's transl)].
    Der Nervenarzt, 1977, Volume: 48, Issue:4

    Topics: Anticonvulsants; Biological Availability; Dose-Response Relationship, Drug; Drug Interactions; Epile

1977
Pediatric psychopharmacology. A review with special reference to deanol.
    Diseases of the nervous system, 1977, Volume: 38, Issue:12 Pt 2

    Topics: Adolescent; Adult; Amphetamines; Animals; Antidepressive Agents, Tricyclic; Attention Deficit Disord

1977
Brain monoamines in seizure mechanism (review).
    Folia psychiatrica et neurologica japonica, 1977, Volume: 31, Issue:3

    Topics: Animals; Brain; Carbonic Anhydrase Inhibitors; Catecholamines; Child; Dextroamphetamine; Dopamine; E

1977
[Epilepsies of infancy and early childhood (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1978, Jun-06, Volume: 67, Issue:23

    Topics: Clonazepam; Electroencephalography; Epilepsy; Humans; Infant; Infant, Newborn; Infant, Newborn, Dise

1978
[Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)].
    Fortschritte der Neurologie, Psychiatrie, und ihrer Grenzgebiete, 1978, Volume: 46, Issue:6

    Topics: Blood Platelets; Drug Interactions; Electroencephalography; Epilepsy; Fatigue; Half-Life; Humans; Ph

1978
Febrile seizures: the treatment controversy.
    The Journal of pediatrics, 1979, Volume: 94, Issue:2

    Topics: Child; Epilepsy; Humans; Nervous System Diseases; Phenobarbital; Phenytoin; Recurrence; Seizures; Se

1979
Febrile convulsions: diagnosis, treatment, and prognosis.
    Pediatric annals, 1979, Volume: 8, Issue:3

    Topics: Child; Epilepsy; Humans; Infant; Intellectual Disability; Intelligence; Meningitis; Phenobarbital; P

1979
The medical treatment of epilepsy: maintenance of drug therapy.
    Pediatric annals, 1979, Volume: 8, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Biological Availability; Bromides; Carbamazepine; Child; Dextroa

1979
The effect of anti-convulsant drugs on cognitive abilities.
    Pharmacology & therapeutics. Part B: General & systematic pharmacology, 1979, Volume: 4, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Cognition; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin;

1979
Pharmacological prophylaxis in the kindling model of epilepsy.
    Archives of neurology, 1977, Volume: 34, Issue:7

    Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carba

1977
Management of seizure disorders: selected aspects. Part I.
    The Journal of pediatrics, 1976, Volume: 89, Issue:4

    Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Child; Chromatography, Gas; Chromatography,

1976
[Critical remarks on the concept of "osteopathia antiepileptica"].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1976, Volume: 28, Issue:9

    Topics: Anticonvulsants; Bone Resorption; Calcium; Epilepsy; Humans; Osteomalacia; Phenytoin; Tetany; Vitami

1976
Neurologic disorders in renal failure (first of two parts).
    The New England journal of medicine, 1976, Jan-15, Volume: 294, Issue:3

    Topics: Blood-Brain Barrier; Brain Diseases; Cerebrospinal Fluid Proteins; Diazepam; Epilepsy; Humans; Lidoc

1976
[Epilepsy and monoamines in the brain].
    Nihon rinsho. Japanese journal of clinical medicine, 1975, Volume: 33, Issue:10

    Topics: Animals; Biogenic Amines; Brain; Catecholamines; Cats; Dihydroxyphenylalanine; Dopamine; Drug Antago

1975
Pharmacological regulation of astrocytic calcium channels: implications for the treatment of seizure disorders.
    Progress in brain research, 1992, Volume: 94

    Topics: Animals; Anticonvulsants; Astrocytes; Calcium; Calcium Channels; Cells, Cultured; Drug Design; Epile

1992
Metabolism of antiepileptic medication: newborn to elderly.
    Epilepsia, 1992, Volume: 33 Suppl 4

    Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Carbamazepine; Child; Dose-Response Relations

1992
Is there a genetic relationship between epilepsy and birth defects?
    Neurology, 1992, Volume: 42, Issue:4 Suppl 5

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Congenital Abnormalities; Dis

1992
Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy.
    Epilepsia, 1991, Volume: 32 Suppl 5

    Topics: Anemia, Aplastic; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Monit

1991
Anticonvulsants: pharmacotherapeutic issues in the critically ill patient.
    AACN clinical issues in critical care nursing, 1991, Volume: 2, Issue:4

    Topics: Anticonvulsants; Benzodiazepines; Brain Injuries; Carbamazepine; Central Nervous System Diseases; Ep

1991
The newer antiepileptic drugs: carbamazepine and valproic acid.
    Pediatric annals, 1991, Volume: 20, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epilepsy; Humans; Infant

1991
Antiepileptic drugs, cognitive function, and behavior in children: evidence from recent studies.
    Epilepsia, 1990, Volume: 31 Suppl 4

    Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Cognition; Cognition Disorders; Epilepsy;

1990
Immunoglobulins in epilepsy.
    Springer seminars in immunopathology, 1985, Volume: 8, Issue:1-2

    Topics: alpha-Fetoproteins; Anticonvulsants; Autoantibodies; Bacterial Infections; DNA; Dysgammaglobulinemia

1985
Medical treatment and pharmacology of antiepileptic drugs.
    Pediatric clinics of North America, 1989, Volume: 36, Issue:2

    Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Epilepsy; Half-Life; Humans; Phenytoin

1989
Efficacy and adverse effects of antiepileptic drugs.
    Pediatric clinics of North America, 1989, Volume: 36, Issue:2

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital

1989
Use of phenytoin and carbamazepine in treatment of epilepsy.
    Neurologic clinics, 1986, Volume: 4, Issue:3

    Topics: Anemia, Aplastic; Carbamazepine; Cerebellar Ataxia; Chemical and Drug Induced Liver Injury; Cognitio

1986
[GABAergic theory of epilepsy].
    La Revue du praticien, 1986, Jan-21, Volume: 36, Issue:5

    Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Dogs; E

1986
[Oral loading dose of phenytoin].
    Revista medica de Chile, 1988, Volume: 116, Issue:11

    Topics: Adult; Aged; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Status Epilepticus

1988
Antiepileptic drugs in adolescents.
    Journal of adolescent health care : official publication of the Society for Adolescent Medicine, 1987, Volume: 8, Issue:1

    Topics: Adaptation, Psychological; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Dru

1987
Mechanisms of anticonvulsant drug action. I. Drugs primarily used for generalized tonic-clonic and partial epilepsies.
    European journal of pediatrics, 1987, Volume: 146, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Humans; Kinetics; Phenobarbital; Phen

1987
Drug treatment of epilepsy.
    Seminars in neurology, 1987, Volume: 7, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Humans; Ph

1987
Anticonvulsant drugs and cognitive function: a review of the literature.
    Epilepsia, 1987, Volume: 28 Suppl 3

    Topics: Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Epilepsy; Humans; Phenobarbital; Phe

1987
[Neurotraumatology and post-traumatic epilepsy. Prevention, treatment and long-term follow-up. Barbexaclone + phenobarbital (maliasin) versus diphenylhydantoin, phenobarbital, primidone, carbamazepine].
    Minerva medica, 1987, Nov-30, Volume: 78, Issue:22

    Topics: Adolescent; Adult; Anticonvulsants; Brain Injuries; Carbamazepine; Child; Child, Preschool; Drug The

1987
[Effect of antiepileptic drugs on thyroid function].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1987, Nov-15, Volume: 40, Issue:22

    Topics: Epilepsy; Humans; Phenytoin; Thyroid Gland

1987
Current concepts. Seizure disorders and pregnancy.
    The New England journal of medicine, 1985, Feb-28, Volume: 312, Issue:9

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Administration Schedule; Epilepsy;

1985
Role of the brain-stem reticular formation in tonic-clonic seizures: lesion and pharmacological studies.
    Federation proceedings, 1985, Volume: 44, Issue:8

    Topics: Acoustic Stimulation; Animals; Brain Stem; Electroshock; Epilepsy; Phenytoin; Reticular Formation; S

1985
Pharmacokinetics of anti-epileptic drugs in the dog: a review.
    Journal of veterinary pharmacology and therapeutics, 1985, Volume: 8, Issue:3

    Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Clonazepam; Diazepam; Dog Diseases; Dogs; E

1985
Febrile convulsions. A reappraisal.
    Electroencephalography and clinical neurophysiology, 1973, Volume: 32

    Topics: Age Factors; Animals; Animals, Newborn; Body Temperature; Brain; Brain Damage, Chronic; Child, Presc

1973
Anticonvulsants, folic acid, and epilepsy.
    Lancet (London, England), 1973, Jun-16, Volume: 1, Issue:7816

    Topics: Anemia, Macrocytic; Animals; Anticonvulsants; Blood-Brain Barrier; Chemical Phenomena; Chemistry; Ep

1973
Usefulness of blood levels of antiepileptic drugs.
    Archives of neurology, 1974, Volume: 31, Issue:5

    Topics: Anticonvulsants; Carbamazepine; Chloramphenicol; Chlordiazepoxide; Chlorpromazine; Chromatography, G

1974
Plasma levels of anticonvulsants.
    Australian and New Zealand journal of medicine, 1973, Volume: 3, Issue:3

    Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Barbiturates; Blood Proteins; Carbamazepine;

1973
Diagnosis and treatment of epilepsy: overview and general principles.
    Pediatrics, 1974, Volume: 53, Issue:4

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination;

1974
[Epilepsy in children].
    Nederlands tijdschrift voor geneeskunde, 1974, Aug-03, Volume: 118, Issue:31

    Topics: Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Absence; Fever; Humans; Infant;

1974
Current drug therapy--antiepilepsy agents.
    American journal of hospital pharmacy, 1974, Volume: 31, Issue:12

    Topics: Anticonvulsants; Barbiturates; Chemical Phenomena; Chemistry; Drug Interactions; Epilepsies, Partial

1974
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
    Epilepsia, 1969, Volume: 10, Issue:2

    Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials

1969
Effects of tetanization on transmitter dynamics.
    Epilepsia, 1969, Volume: 10, Issue:2

    Topics: Acetazolamide; Acetylcholine; Action Potentials; Animals; Biological Transport; Carbon Dioxide; Cell

1969
Current trends in Australian neurology.
    Postgraduate medical journal, 1970, Volume: 46, Issue:534

    Topics: Alcoholism; Amino Acids; Aminobutyrates; Animals; Australia; Catecholamines; Central Nervous System;

1970
[Calcium metabolism disorders in antiepileptic therapy].
    Deutsche medizinische Wochenschrift (1946), 1973, May-18, Volume: 98, Issue:20

    Topics: Animals; Anticonvulsants; Bone Diseases; Calcium; Calcium Metabolism Disorders; Cholecalciferol; Enz

1973
A basic approach to the understanding of seizures and the mechanism of action and metabolism of anticonvulsants.
    Advances in pediatrics, 1973, Volume: 20, Issue:0

    Topics: Acetylcholine; Aminobutyrates; Anticonvulsants; Calcium; Cell Membrane Permeability; Depression, Che

1973
Toxic effects of anticonvulsants: general principles.
    Pediatrics, 1974, Volume: 53, Issue:4

    Topics: Adrenocorticotropic Hormone; Adult; Anticonvulsants; Benzodiazepinones; Body Surface Area; Body Weig

1974
Disordered calcium metabolism during anticonvulsant treatment.
    German medicine, 1973,Winter, Volume: 3, Issue:3-4

    Topics: Adolescent; Animals; Anticonvulsants; Biliary Tract; Bone Diseases; Calcium; Child; Cholecalciferol;

1973
Epilepsy.
    Progress in neurology and psychiatry, 1967, Volume: 22

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Amphetamine; Anesthetics, Local; Anticonvulsants; Ba

1967
The management of children with epilepsy.
    The Practitioner, 1970, Volume: 204, Issue:219

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Electroencephalography; Epilepsy; Ethosuxim

1970
[The action of hydantoinate in the organism during the therapy of epilepsy with special reference to the origin of gingival hyperplasia. Review II].
    Ceskoslovenska stomatologie, 1972, Volume: 72, Issue:3

    Topics: Animals; Culture Techniques; Epilepsy; Gingival Hyperplasia; Humans; Hydantoins; Phenytoin

1972
Epilepsy.
    Progress in neurology and psychiatry, 1972, Volume: 27

    Topics: Animals; Brain; Carbamazepine; Diet Therapy; Epilepsy; Humans; Phenobarbital; Phenytoin

1972
Clinical pharmacology of drug interactions.
    Annual review of medicine, 1973, Volume: 24

    Topics: Antihypertensive Agents; Blood Coagulation Disorders; Cardiovascular Diseases; Coumarins; Drug Inter

1973
Recent progress in epilepsy. Diagnostic procedures and treatment.
    California medicine, 1973, Volume: 119, Issue:1

    Topics: Anticonvulsants; Brain Neoplasms; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Temporal Lob

1973
Cerebrospinal folate levels in epileptics and their response to folate therapy.
    Nutrition reviews, 1974, Volume: 32, Issue:3

    Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Def

1974
Epilepsy in the adolescent.
    Postgraduate medicine, 1974, Volume: 55, Issue:4

    Topics: Acetazolamide; Adolescent; Age Factors; Alcoholic Intoxication; Amphetamine; Anticonvulsants; Attitu

1974
The treatment of status epilepticus.
    Pediatrics, 1974, Volume: 53, Issue:4

    Topics: Anti-Bacterial Agents; Anticonvulsants; Barbiturates; Brain Edema; Central Nervous System Diseases;

1974
The use of blood levels of antiepileptic drugs in clinical practice.
    Pediatrics, 1974, Volume: 53, Issue:4

    Topics: Administration, Oral; Adult; Anticonvulsants; Biopharmaceutics; Carbamazepine; Child; Drug Tolerance

1974
[Considerations and observations on the pharmacotoxicology of antiepileptic drugs].
    Der Nervenarzt, 1974, Volume: 45, Issue:3

    Topics: Adolescent; Anticonvulsants; Benzazepines; Epilepsy; Gait; Humans; Libido; Male; Movement Disorders;

1974
Epileptic therapy and gingival considerations.
    Revue dentaire libanaise. Lebanese dental magazine, 1974, Volume: 24, Issue:2

    Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Disease Models, Animal; Epilepsy; Female; Gingi

1974
Individualization of anticonvulsant therapy.
    The Medical clinics of North America, 1974, Volume: 58, Issue:5

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Body Weight; Dose-Response Relationship, Drug; Drug Int

1974
Convulsions in children.
    The New England journal of medicine, 1968, Feb-08, Volume: 278, Issue:6

    Topics: Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Ethosuximide; Humans; Infant; M

1968
Neuropharmacology of diphenylhydantoin.
    International journal of neuropsychiatry, 1967, Volume: 3

    Topics: Animals; Brain; Cell Membrane Permeability; Epilepsy; Feedback; Humans; Learning; Neurons; Phenytoin

1967
Diphenylhydantoin. Its usefulness in clinical disorders of a non-epileptic nature. Discussion on safety.
    International journal of neuropsychiatry, 1967, Volume: 3

    Topics: Epilepsy; Humans; Mental Disorders; Phenytoin

1967
Anticonvulsant therapy and serum folate.
    Nutrition reviews, 1969, Volume: 27, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Depression, Chemical; Epilepsy; Female;

1969
[On the clinical features, histology and etiology of gingival hyperplasia and the hydantoins].
    Zahnarztliche Welt, zahnarztliche Rundschau, ZWR, vereinigt mit Zahnarztliche Reform, 1969, Jan-10, Volume: 78, Issue:1

    Topics: Diagnosis, Differential; Drug Hypersensitivity; Epilepsy; Gingival Hyperplasia; Humans; Hydantoins;

1969
Role of pharmacological factors in the evaluation of anticonvulsant drugs.
    Epilepsia, 1969, Volume: 10, Issue:2

    Topics: Acid-Base Equilibrium; Age Factors; Animals; Anticonvulsants; Body Temperature; Cats; Central Nervou

1969
Periodontal disease.
    The New England journal of medicine, 1971, May-13, Volume: 284, Issue:19

    Topics: Adult; Ascorbic Acid Deficiency; Bone Resorption; Child; Dental Deposits; Dental Plaque; Endotoxins;

1971
Osteomalacia and anticonvulsant drugs.
    Nutrition reviews, 1971, Volume: 29, Issue:2

    Topics: Alkaline Phosphatase; Anticonvulsants; Calcium; Epilepsy; Folic Acid; Humans; Liver; Osteomalacia; P

1971
[General review of the present therapy of epilepsy].
    Neuropsihijatrija, 1971, Volume: 19, Issue:1

    Topics: Anticonvulsants; Barbiturates; Chlordiazepoxide; Diazepam; Epilepsy; Humans; Hydantoins; Phenobarbit

1971
[Drug therapy of epilepsy].
    Naika. Internal medicine, 1967, Volume: 19, Issue:6

    Topics: Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenobarbital; Phenytoin; Trimethadione; Urea

1967

Trials

191 trials available for phenytoin and Aura

ArticleYear
AntiEpileptic drug Monitoring in PREgnancy (EMPiRE): a double-blind randomised trial on effectiveness and acceptability of monitoring strategies.
    Health technology assessment (Winchester, England), 2018, Volume: 22, Issue:23

    Topics: Anticonvulsants; Carbamazepine; Double-Blind Method; Drug Monitoring; Epilepsy; Female; Humans; Lamo

2018
Effect of switching hepatic enzyme-inducer antiepileptic drug to levetiracetam on bone mineral density, 25 hydroxyvitamin D, and parathyroid hormone in young adult patients with epilepsy.
    Epilepsia, 2013, Volume: 54, Issue:6

    Topics: Adult; Anticonvulsants; Bone Density; Epilepsy; Female; Femur; Humans; Levetiracetam; Lumbar Vertebr

2013
Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia.
    BioMed research international, 2016, Volume: 2016

    Topics: Acetylcarnitine; Adolescent; Adult; Aged; Aged, 80 and over; Ammonia; Bipolar Disorder; Carnitine; E

2016
Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin.
    Acta neurologica Scandinavica, 2008, Volume: 118, Issue:5

    Topics: Acute Disease; Adult; Aged; Anticonvulsants; Brain; Drug-Related Side Effects and Adverse Reactions;

2008
Anticonvulsant use and outcomes after intracerebral hemorrhage.
    Stroke, 2009, Volume: 40, Issue:12

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Cerebral Hemorrhage; Combined Modality Therapy; Craniotomy

2009
Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new-onset epilepsy: a randomized double-blind clinical trial.
    Epilepsia, 2010, Volume: 51, Issue:10

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anticonvulsants; Child; Dose-Response Relationship, D

2010
Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new-onset epilepsy: a randomized double-blind clinical trial.
    Epilepsia, 2010, Volume: 51, Issue:10

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anticonvulsants; Child; Dose-Response Relationship, D

2010
Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new-onset epilepsy: a randomized double-blind clinical trial.
    Epilepsia, 2010, Volume: 51, Issue:10

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anticonvulsants; Child; Dose-Response Relationship, D

2010
Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new-onset epilepsy: a randomized double-blind clinical trial.
    Epilepsia, 2010, Volume: 51, Issue:10

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anticonvulsants; Child; Dose-Response Relationship, D

2010
Population pharmacokinetics of carbamazepine in elderly patients.
    Therapeutic drug monitoring, 2012, Volume: 34, Issue:2

    Topics: Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Body Weight; Carbamazepine; Dose-Response Rel

2012
Results of phase 2 safety and feasibility study of treatment with levetiracetam for prevention of posttraumatic epilepsy.
    Archives of neurology, 2012, Volume: 69, Issue:10

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Brain Injuries; Child; Chr

2012
Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study.
    The Lancet. Neurology, 2013, Volume: 12, Issue:3

    Topics: Adult; Anticonvulsants; Child; Child Development; Child, Preschool; Cognition; Epilepsy; Female; Hum

2013
Randomized evaluation of adverse events and length-of-stay with routine emergency department use of phenytoin or fosphenytoin.
    Neurological research, 2002, Volume: 24, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Drug Administration Schedule; Drug Therapy, Combination; Emergency S

2002
Microdialysis sampling of carbamazepine, phenytoin and phenobarbital in subcutaneous extracellular fluid and subdural cerebrospinal fluid in humans: an in vitro and in vivo study of adsorption to the sampling device.
    Pharmacology & toxicology, 2002, Volume: 91, Issue:4

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Extracellular Space; Female; Humans; Male; Microdia

2002
Phenytoin and phenobarbital stable isotope studies in neonates.
    Pediatric neurology, 2003, Volume: 29, Issue:5

    Topics: Anticonvulsants; Carbon Isotopes; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Infant; In

2003
Prophylactic phenytoin does not improve cerebral edema or survival in acute liver failure--a controlled clinical trial.
    Journal of hepatology, 2004, Volume: 41, Issue:1

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain Edema; Epilepsy; Female; Humans; Liver Failure, Acut

2004
Increased depressant effect of phenytoin sodium as compared to carbamazepine on cortical excitability: a transcranial magnetic evaluation.
    Neurology India, 2004, Volume: 52, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Magnetoencephalography; Male; Pheny

2004
Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect.
    Journal of the Indian Society of Pedodontics and Preventive Dentistry, 2004, Volume: 22, Issue:2

    Topics: Adolescent; Anticonvulsants; Child; Dental Plaque; Epilepsy; Folic Acid; Follow-Up Studies; Gingival

2004
Lack of a clinically significant effect of zonisamide on phenytoin steady-state pharmacokinetics in patients with epilepsy.
    Journal of clinical pharmacology, 2004, Volume: 44, Issue:11

    Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Drug Interactions; Epilepsy; Female; Humans; I

2004
Serum albumin-adjusted phenytoin levels: an approach for predicting drug efficacy in patients with epilepsy, suitable for developing countries.
    International journal of clinical pharmacology and therapeutics, 2004, Volume: 42, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Developing Countries; Drug Monitoring; Epilepsy; False Positive

2004
Evaluation of phenytoin dosage regimens based on genotyping of CYP2C subfamily in routinely treated Japanese patients.
    Drug metabolism and pharmacokinetics, 2005, Volume: 20, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Asian People; Bayes Theorem; Child; Child, Preschool; Cytochrome

2005
Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy.
    Neurology, 2005, Oct-11, Volume: 65, Issue:7

    Topics: Adolescent; Adult; Age Factors; Aging; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Down

2005
Evaluation of antiepileptic drugs in pregnancy in a Jordanian army hospital.
    Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit, 2005, Volume: 11, Issue:4

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Clinical Protocols; Drug Monitor

2005
Chronotherapeutic dose schedule of phenytoin and carbamazepine in epileptic patients.
    Chronobiology international, 2006, Volume: 23, Issue:5

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Chronotherapy; Dose-Response Relationship,

2006
Albendazole therapy for single small enhancing CT lesions (SSECTL) in the brain in epilepsy.
    Journal of neurology, neurosurgery, and psychiatry, 2008, Volume: 79, Issue:3

    Topics: Adolescent; Adult; Albendazole; Anthelmintics; Carbamazepine; Cerebral Cortex; Child; Child, Prescho

2008
Ineffectiveness of folic acid supplementation against phenytoin-induced decrease in salivary immunoglobulin A concentration of epileptic patients.
    European neurology, 2008, Volume: 59, Issue:6

    Topics: Dietary Supplements; Epilepsy; Female; Folic Acid; Humans; IgA Deficiency; Male; Middle Aged; Phenyt

2008
Postoperative epilepsy: a double-blind trial of phenytoin after craniotomy.
    Lancet (London, England), 1980, Feb-23, Volume: 1, Issue:8165

    Topics: Clinical Trials as Topic; Craniotomy; Double-Blind Method; Epilepsy; Humans; Phenytoin; Postoperativ

1980
Serum concentrations and enzyme induction in epileptic children treated with phenytoin and valproate.
    Neuropediatrics, 1982, Volume: 13, Issue:1

    Topics: Child; Enzyme Induction; Epilepsy; gamma-Glutamyltransferase; Humans; Phenytoin; Valproic Acid

1982
Historical perspective on the choice of antiepileptic drugs for the treatment of seizures in adults.
    Neurology, 1983, Volume: 33, Issue:3 Suppl 1

    Topics: Adult; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Epilepsy; History, 20th Century; Hu

1983
Phenytoin and postoperative epilepsy. A double-blind study.
    Journal of neurosurgery, 1983, Volume: 58, Issue:5

    Topics: Clinical Trials as Topic; Craniotomy; Double-Blind Method; Epilepsy; Female; Humans; Male; Middle Ag

1983
Phenytoin revisited.
    Clinical therapeutics, 1984, Volume: 6, Issue:5

    Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Cerebrovascular Disorders; Clinical Trials as Topic;

1984
[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and child development].
    Deutsche medizinische Wochenschrift (1946), 1983, Feb-18, Volume: 108, Issue:7

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Akathisia, Drug-Induced; Anencephaly; Ant

1983
Controlled and comparative trials of valproate performed in Europe and Asia.
    Epilepsia, 1984, Volume: 25 Suppl 1

    Topics: Adolescent; Adult; Asia; Carbamazepine; Child; Clinical Trials as Topic; Epilepsy; Europe; Humans; P

1984
Controlled and comparative trials with valproate: United States.
    Epilepsia, 1984, Volume: 25 Suppl 1

    Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Epilepsy; Epilepsy, Absence; E

1984
A randomised trial of strategies to improve patient compliance with anticonvulsant therapy.
    Epilepsia, 1984, Volume: 25, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Counseling; Drug Packag

1984
Influence of therapeutic phenobarbital and phenytoin medication on the polygraphic sleep of patients with epilepsy.
    Epilepsia, 1984, Volume: 25, Issue:4

    Topics: Adolescent; Adult; Aged; Drug Interactions; Epilepsies, Partial; Epilepsy; Female; Humans; Male; Mid

1984
Role of combination of valproic acid with diphenylhydantoin and carbamazepine in the management of intractable seizures.
    The Journal of the Association of Physicians of India, 1984, Volume: 32, Issue:7

    Topics: Adolescent; Adult; Carbamazepine; Clinical Trials as Topic; Drug Therapy, Combination; Epilepsy; Fem

1984
Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy.
    Epilepsia, 1981, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Pregnancy; T

1981
A comparison of phenytoin and valproate in previously untreated adult epileptic patients.
    Journal of neurology, neurosurgery, and psychiatry, 1982, Volume: 45, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Humans

1982
A comparison of phenytoin and pheneturide in patients with epilepsy: a double-blind cross-over trial.
    Journal of neurology, neurosurgery, and psychiatry, 1982, Volume: 45, Issue:12

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Clinical Trials as Topic; Double-Blind Method; Epilepsies,

1982
Influence of dextropropoxyphene on steady state serum levels and protein binding of three anti-epileptic drugs in man.
    Acta neurologica Scandinavica, 1980, Volume: 61, Issue:6

    Topics: Adolescent; Adult; Aged; Carbamazepine; Chromatography, Gas; Chromatography, High Pressure Liquid; C

1980
The influence of folic acid on the frequency of epileptic attacks.
    European journal of clinical pharmacology, 1981, Volume: 19, Issue:1

    Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Epilepsy; Female; Folic Acid; Humans; Male; Ph

1981
Kinetics of phenobarbital in normal subjects and epileptic patients.
    European journal of clinical pharmacology, 1982, Volume: 23, Issue:1

    Topics: Administration, Oral; Adult; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Injec

1982
Phenytoin and cognitive function: effects on normal volunteers and implications for epilepsy.
    The British journal of clinical psychology, 1981, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Attention; Cognition; Decision Making; Epilepsy; Humans; Male; Memory; Motor Skil

1981
Comparing the cognitive effects of phenytoin and carbamazepine in long-term monotherapy: a two-year follow-up.
    Epilepsia, 1995, Volume: 36, Issue:12

    Topics: Adult; Affect; Carbamazepine; Cognition; Epilepsy; Female; Follow-Up Studies; Humans; Male; Neuropsy

1995
New anticonvulsant drugs. Focus on flunarizine, fosphenytoin, midazolam and stiripentol.
    Drugs, 1994, Volume: 48, Issue:2

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; Cross-Over Studies; Dioxolanes

1994
Thyroid status of patients receiving long-term anticonvulsant therapy assessed by peripheral parameters: a placebo-controlled thyroxine therapy trial.
    Epilepsia, 1995, Volume: 36, Issue:11

    Topics: Adult; Age Distribution; Anticonvulsants; Carbamazepine; Comorbidity; Cross-Over Studies; Double-Bli

1995
Systematic approach to a dosage regimen for phenytoin based on one-point, steady-state plasma concentration.
    Therapeutic drug monitoring, 1995, Volume: 17, Issue:1

    Topics: Adult; Bayes Theorem; Epilepsy; Female; Humans; Male; Phenytoin; Retrospective Studies

1995
[Effects of phenytoin and cabamazepine on sex hormones in male patients with epilepsy: a controlled study].
    Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 1994, Volume: 25, Issue:2

    Topics: Adolescent; Adult; Carbamazepine; Case-Control Studies; Epilepsy; Estradiol; Humans; Male; Phenytoin

1994
Cognitive side-effects of phenytoin compared with carbamazepine in patients with localization-related epilepsy.
    Epilepsy research, 1994, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Attention; Carbamazepine; Cognition Disorders; Epilepsy; Female; Humans; Male; Me

1994
Clinical rules for phenytoin dosing.
    The Annals of pharmacotherapy, 1993, Volume: 27, Issue:10

    Topics: Adult; Computer Simulation; Drug Therapy, Computer-Assisted; Epilepsy; Female; Humans; Male; Middle

1993
Renal tubular dysfunction following treatment with anti-epileptic drugs.
    European journal of pediatrics, 1994, Volume: 153, Issue:11

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross-Sectional Studies; Epilep

1994
Flunarizine for treatment of partial seizures: results of a concentration-controlled trial.
    Neurology, 1994, Volume: 44, Issue:10

    Topics: Adolescent; Adult; Aged; Carbamazepine; Dose-Response Relationship, Drug; Double-Blind Method; Drug

1994
[Clinical analysis of 72 epileptic patients treated with alkaline extract of Euphorbia fisheriana].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1994, Volume: 14, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Drugs, Chinese

1994
Pharmacokinetics of phenytoin in routine clinic patients in Malaysia.
    Journal of clinical pharmacy and therapeutics, 1994, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Asian People; Body Weight; Child; Epilepsy; Female; Humans; Linear Models; Malays

1994
Dosage adjustments in response to monitored plasma concentrations: can unblinded staff adhere to objective criteria?
    Journal of biopharmaceutical statistics, 1994, Volume: 4, Issue:1

    Topics: Attitude of Health Personnel; Carbamazepine; Dose-Response Relationship, Drug; Double-Blind Method;

1994
A double-blind, placebo-controlled interaction study between oxcarbazepine and carbamazepine, sodium valproate and phenytoin in epileptic patients.
    British journal of clinical pharmacology, 1994, Volume: 37, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Double-Blind Method; Drug Interactions; Epilepsy; Female; Hal

1994
Effects of phenytoin and carbamazepine on cognitive functions in newly diagnosed epileptic patients.
    Acta neurologica Scandinavica, 1994, Volume: 89, Issue:2

    Topics: Adult; Carbamazepine; Cognition Disorders; Epilepsy; Female; Follow-Up Studies; Humans; Learning; Ma

1994
Carbamazepine and phenytoin in epilepsies refractory to barbiturates: efficacy, toxicity and mental function.
    Epilepsy research, 1993, Volume: 16, Issue:2

    Topics: Adolescent; Adult; Affect; Carbamazepine; Child; Cognition; Epilepsies, Partial; Epilepsy; Female; H

1993
Thiamine and folate treatment of chronic epileptic patients: a controlled study with the Wechsler IQ scale.
    Epilepsy research, 1993, Volume: 16, Issue:2

    Topics: Adult; Brain; Double-Blind Method; Drug Therapy, Combination; Education; Electroencephalography; Epi

1993
Developmental and therapeutic pharmacology of antiepileptic drugs.
    The Japanese journal of psychiatry and neurology, 1993, Volume: 47, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Dru

1993
Comparison of the effectiveness of two oral phenytoin products and chronopharmacokinetics of phenytoin.
    Journal of clinical pharmacy and therapeutics, 1993, Volume: 18, Issue:3

    Topics: Administration, Oral; Adult; Biological Availability; Circadian Rhythm; Drug Administration Schedule

1993
Withdrawal of antiepileptic medication in children--effects on cognitive function: The Multicenter Holmfrid Study.
    Neurology, 1993, Volume: 43, Issue:1

    Topics: Adolescent; Carbamazepine; Child; Cognition; Cognition Disorders; Epilepsy; Female; Follow-Up Studie

1993
Psychiatric aspects of epilepsy in childhood treated with carbamazepine, phenytoin or sodium valproate: a random trial.
    Developmental medicine and child neurology, 1993, Volume: 35, Issue:2

    Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Humans; Mal

1993
Effect of felbamate on carbamazepine and its major metabolites.
    Clinical pharmacology and therapeutics, 1993, Volume: 53, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Double-Blind Method; Drug Interactions; Epilepsy;

1993
Phenytoin as a risk factor in gingival hyperplasia.
    Therapeutic drug monitoring, 1995, Volume: 17, Issue:5

    Topics: Adult; Analysis of Variance; Anticonvulsants; Chi-Square Distribution; Drug Therapy, Combination; Ep

1995
A comparison of the OPUS and TDx analysers for antiepileptic drug monitoring.
    Therapeutic drug monitoring, 1995, Volume: 17, Issue:5

    Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Female; Fluorescence Polarization Immunoa

1995
Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy.
    Lancet (London, England), 1996, Mar-16, Volume: 347, Issue:9003

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy;

1996
Assessment of drowsiness in epilepsy patients receiving chronic antiepileptic drug therapy.
    Epilepsia, 1996, Volume: 37, Issue:2

    Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy; Humans; Middle

1996
Systematic testing of medical intractability for carbamazepine, phenytoin, and phenobarbital or primidone in monotherapy for patients considered for epilepsy surgery.
    Epilepsia, 1996, Volume: 37, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clinical Protocols; Dose

1996
Safety and tolerance of multiple doses of intramuscular fosphenytoin substituted for oral phenytoin in epilepsy or neurosurgery.
    Archives of neurology, 1996, Volume: 53, Issue:8

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Drug Tolerance; Epilepsy; Female; Humans; Male; Middle Age

1996
Effect of enzyme inducing anticonvulsants on ethosuximide pharmacokinetics in epileptic patients.
    British journal of clinical pharmacology, 1996, Volume: 41, Issue:6

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Enzyme Induction; Epilepsy; Ethosuximide;

1996
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
    Acta paediatrica (Oslo, Norway : 1992), 1996, Volume: 85, Issue:6

    Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System

1996
Brainstem auditory evoked potentials in epileptics on different anti-epileptic drugs.
    Indian journal of physiology and pharmacology, 1996, Volume: 40, Issue:1

    Topics: Acoustic Stimulation; Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Combinations; Epilepsy

1996
Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication.
    Therapeutic drug monitoring, 1996, Volume: 18, Issue:5

    Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; D

1996
Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: analysis with a dose-dependent clearance model.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:3

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Biological Availability; Child; Child, Preschool; D

1996
Findings in children exposed in utero to phenytoin and carbamazepine monotherapy: independent effects of epilepsy and medications.
    American journal of medical genetics, 1997, Jan-10, Volume: 68, Issue:1

    Topics: Adult; Carbamazepine; Cohort Studies; Craniofacial Abnormalities; Epilepsy; Female; Fingers; Humans;

1997
Phenytoin kinetics in Japanese adult epileptics: phenotype of phenytoin slow metabolizers.
    Clinical neuropharmacology, 1997, Volume: 20, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Japa

1997
Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy.
    Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Bayes Theorem; Child; Child, Pres

1997
Homocyst(e)ine levels in patients on phenytoin therapy.
    Clinical biochemistry, 1997, Volume: 30, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Epilepsy; Female; Homocysteine; Humans;

1997
Cognitive effects of anticonvulsant monotherapy in elderly patients: a placebo-controlled study.
    Seizure, 1998, Volume: 7, Issue:2

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Cognition Disorders; Dose-Response Relation

1998
Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy.
    Epilepsia, 1998, Volume: 39, Issue:9

    Topics: Adolescent; Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; C

1998
Antiepileptic drug therapy and sexual function in men with epilepsy.
    Epilepsia, 1999, Volume: 40, Issue:2

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Androgen-Binding Protein; Androstenedione; Anticonvul

1999
[Treatment for generalized seizures: the best of four methods].
    Presse medicale (Paris, France : 1983), 1999, Jan-23, Volume: 28, Issue:3

    Topics: Anticonvulsants; Diazepam; Epilepsy; Humans; Lorazepam; Phenobarbital; Phenytoin

1999
Anti-epileptic drug intake adherence. The value of the blood drug level measurement and the clinical approach.
    Arquivos de neuro-psiquiatria, 1998, Volume: 56, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Drug Monitoring; Epilepsy; Female; Humans;

1998
Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study.
    Brain : a journal of neurology, 1999, Volume: 122 ( Pt 3)

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Combinations; Epilepsy; Female; Human

1999
Spotlight on the continual applicability of routine plasma monitoring antiepileptic drugs in the treatment of epilepsy.
    Pharmacological research, 1999, Volume: 39, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Monitoring; Drug Therapy, Combination; Epile

1999
Genotoxicity of the anticonvulsant drug phenytoin (PHT): a follow-up study of PHT-untreated epileptic patients. I. Sister chromatid exchange (SCE) analysis.
    Teratogenesis, carcinogenesis, and mutagenesis, 1999, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Age Factors; Age of Onset; Anticonvulsants; Child; Epilepsy; Female; Humans; Male

1999
Fracture risk is increased in epilepsy.
    Acta neurologica Scandinavica, 1999, Volume: 99, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Biomechanical Phenomena; Epilepsy; Fema

1999
Lamotrigine monotherapy in newly diagnosed untreated epilepsy: a double-blind comparison with phenytoin.
    Epilepsia, 1999, Volume: 40, Issue:5

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Double-Blind Method; Drug Administration Schedule; Epileps

1999
Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study.
    Epilepsia, 1999, Volume: 40, Issue:7

    Topics: Acetates; Adolescent; Adult; Ambulatory Care; Amines; Anticonvulsants; Asthenia; Carbamazepine; Cycl

1999
A case control study and one year follow-up of registered epilepsy cases in a resettlement colony of North India, a developing tropical country.
    Journal of the neurological sciences, 1999, May-01, Volume: 165, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Child; Craniocerebral Trauma; Developmenta

1999
Coadministration of phenytoin and felbamate: evidence of additional phenytoin dose-reduction requirements based on pharmacokinetics and tolerability with increasing doses of felbamate.
    Epilepsia, 1999, Volume: 40, Issue:8

    Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interac

1999
Comparative double blind clinical trial of phenytoin and sodium valproate as anticonvulsant prophylaxis after craniotomy: efficacy, tolerability, and cognitive effects.
    Journal of neurology, neurosurgery, and psychiatry, 1999, Volume: 67, Issue:4

    Topics: Adult; Aged; Brain Diseases; Cognition; Craniotomy; Double-Blind Method; Epilepsy; Female; Humans; M

1999
Age-related alteration of carbamazepine-serum protein binding in man.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anticonvulsants; Child; Child, Preschool; Diethyl

1999
Optimization of phenytoin therapy in adults with epilepsy in the Western Cape, South Africa.
    Journal of clinical pharmacy and therapeutics, 1999, Volume: 24, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Dose-Response Relationship, Drug; Epile

1999
Lack of pharmacokinetic interaction between grapefruit juice and phenytoin in healthy male volunteers and epileptic patients.
    Methods and findings in experimental and clinical pharmacology, 1999, Volume: 21, Issue:9

    Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Fruit; Humans; Male; Middle Aged; Phenytoin; Se

1999
Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus.
    Pharmacogenetics, 2000, Volume: 10, Issue:1

    Topics: Alleles; Amino Acid Substitution; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome

2000
Total percentage body weight changes during add-on therapy with tiagabine, carbamazepine and phenytoin.
    Epilepsy research, 2000, Volume: 41, Issue:1

    Topics: Anticonvulsants; Body Weight; Carbamazepine; Double-Blind Method; Drug Therapy, Combination; Epileps

2000
Topiramate in refractory epilepsy: a prospective observational study.
    Epilepsia, 2000, Volume: 41, Issue:8

    Topics: Adolescent; Adult; Aged; Ambulatory Care; Anticonvulsants; Carbamazepine; Drug Administration Schedu

2000
Influence of vitamin D administration on bone ultrasound measurements in patients on anticonvulsant therapy.
    European journal of clinical investigation, 2000, Volume: 30, Issue:10

    Topics: 25-Hydroxyvitamin D 2; Adult; Aged; Anticonvulsants; Bone and Bones; Calcifediol; Carbamazepine; Epi

2000
Fosphenytoin: pharmacokinetics and tolerance of intramuscular loading doses.
    Epilepsia, 2001, Volume: 42, Issue:2

    Topics: Adolescent; Anticonvulsants; Child; Dose-Response Relationship, Drug; Double-Blind Method; Drug Admi

2001
Effect of temperature on binding characteristics of phenytoin to serum proteins in monotherapy adult patients with epilepsy.
    American journal of therapeutics, 2000, Volume: 7, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Blood Proteins; Epilepsy; Female; Humans; Male; Middle Aged; Phe

2000
A prospective study of the incidence of the purple glove syndrome.
    Epilepsia, 2001, Volume: 42, Issue:9

    Topics: Aged; Anticonvulsants; Edema; Epilepsy; Female; Forearm; Hand; Humans; Incidence; Infusions, Intrave

2001
Prospective study of local cutaneous reactions in patients receiving IV phenytoin.
    Neurology, 2001, Oct-23, Volume: 57, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Contusions; Edema; Epilepsy; Female; Humans; Incide

2001
Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 800 mg/day) in a B.I.D. regimen.
    Seizure, 2002, Volume: 11, Issue:2

    Topics: Acetamides; Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Confid

2002
Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 1200 mg/day) in a Q.I.D. regimen.
    Seizure, 2002, Volume: 11, Issue:2

    Topics: Acetamides; Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Dose-R

2002
[Evaluation of antiepileptic therapy during pregnancy].
    Ginekologia polska, 2002, Volume: 73, Issue:1

    Topics: Adult; Anticonvulsants; Apgar Score; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenobarbi

2002
Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs.
    Therapeutic drug monitoring, 2002, Volume: 24, Issue:3

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Dr

2002
Seizure reduction and quality of life improvements in people with epilepsy.
    Epilepsia, 2002, Volume: 43, Issue:5

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Attitude to Health; Carbamazepine; Drug Therapy, Combinati

2002
Letter: Bioavailability of phenytoin.
    Lancet (London, England), 1976, Jan-31, Volume: 1, Issue:7953

    Topics: Adolescent; Adult; Biological Availability; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin

1976
Letter: Serum-phenytoin.
    Lancet (London, England), 1976, Jan-31, Volume: 1, Issue:7953

    Topics: Adult; Biological Availability; Child; Epilepsy; Humans; Male; Phenytoin; Time Factors

1976
One drug (phenytoin) in the treatment of epilepsy.
    Lancet (London, England), 1976, May-01, Volume: 1, Issue:7966

    Topics: Adolescent; Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Epilepsy; Epilepsy, Absence; Ep

1976
Carbamazepine vs phenytoin. A controlled clinical trial in focal motor and generalized epilepsy.
    Archives of neurology, 1979, Volume: 36, Issue:1

    Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epilepsies, P

1979
Loading and conventional dose therapy with phenytoin in children: kinetic profile of parent drug and main metabolite in plasma.
    Clinical pharmacology and therapeutics, 1976, Volume: 20, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Clinical Trials as Topic; Drug Administration Schedule; Drug Er

1976
[Value of anticonvulsant level determination in the treatment of epilepsies].
    La Nouvelle presse medicale, 1977, Mar-12, Volume: 6, Issue:10

    Topics: Clinical Trials as Topic; Drug Administration Schedule; Epilepsy; Humans; Patient Dropouts; Phenobar

1977
[Experiences with sodium 2-propyl valerate (Depakine) in the treatment of epilepsy].
    Nederlands tijdschrift voor geneeskunde, 1977, Apr-02, Volume: 121, Issue:14

    Topics: Adolescent; Adult; Aged; Carbamazepine; Cerebrospinal Fluid Shunts; Child; Child, Preschool; Clinica

1977
Long-term use of phenytoin: effects on bone-marrow chromosomes in man.
    Mutation research, 1977, Volume: 43, Issue:2

    Topics: Adolescent; Adult; Bone Marrow; Bone Marrow Cells; Child; Child, Preschool; Chromosome Aberrations;

1977
Valproate sodium: a controlled clinical trial including monitoring of drug levels.
    Epilepsia, 1977, Volume: 18, Issue:2

    Topics: Adult; Child; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Drug Therapy, Combinat

1977
Psychotropic effects of carbamazepine in epilepsy: a double-blind comparison with phenytoin.
    Neurology, 1977, Volume: 27, Issue:11

    Topics: Adult; Attention; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Emo

1977
Oral use of chlorhexidine gluconate toothpaste in epileptic children.
    Scandinavian journal of dental research, 1978, Volume: 86, Issue:1

    Topics: Administration, Oral; Adolescent; Biguanides; Child; Child, Preschool; Chlorhexidine; Clinical Trial

1978
Valproic acid in epilepsy: clinical and pharmacological effects.
    Annals of neurology, 1978, Volume: 3, Issue:1

    Topics: Adult; Binding, Competitive; Biological Availability; Blood Proteins; Clinical Trials as Topic; Drug

1978
Clonazepam: its efficacy in association with phenytoin and phenobarbital in mental patients with generalized major motor seizures.
    International journal of clinical pharmacology and biopharmacy, 1978, Volume: 16, Issue:6

    Topics: Benzodiazepinones; Clinical Trials as Topic; Clonazepam; Double-Blind Method; Drug Therapy, Combinat

1978
Carbamazepine and the electroencephalogram of epileptics: a double blind study in comparison to phenytoin.
    Epilepsia, 1978, Volume: 19, Issue:3

    Topics: Adult; Carbamazepine; Clinical Trials as Topic; Electroencephalography; Epilepsy; Humans; Hyperventi

1978
Sodium valproate, serum level and clinical effect in epilepsy: a controlled study.
    Epilepsia, 1979, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Dimethadione; Dose-Response Relati

1979
Fractional intestinal calcium absorption in epileptics on anticonvulsant therapy. Short-term effect of 1,25-dihydroxycholecalciferol and 25-hydroxycholecalciferol.
    Acta medica Scandinavica, 1979, Volume: 205, Issue:5

    Topics: Administration, Oral; Adult; Alkaline Phosphatase; Anticonvulsants; Calcium; Dihydroxycholecalcifero

1979
The therapeutic range for phenytoin--a reappraisal.
    Irish journal of medical science, 1979, Volume: 148, Issue:2

    Topics: Adolescent; Adult; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Prospective Studie

1979
One drug for epilepsy.
    British medical journal, 1978, Feb-25, Volume: 1, Issue:6111

    Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoi

1978
Phenytoin dosage in ambulant epileptic patients.
    Journal of neurology, neurosurgery, and psychiatry, 1978, Volume: 41, Issue:5

    Topics: Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phenytoin

1978
Oral and intramuscular phenytoin.
    Clinical pharmacology and therapeutics, 1976, Volume: 19, Issue:3

    Topics: Administration, Oral; Adult; Clinical Trials as Topic; Drug Administration Schedule; Epilepsy; Epile

1976
Control of epilepsy with a single daily dose of phenytoin sodium.
    British journal of clinical pharmacology, 1975, Volume: 2, Issue:5

    Topics: Adolescent; Adult; Clinical Trials as Topic; Epilepsy; Female; Humans; Male; Phenytoin

1975
[Changes in serum concentrations of calcium and inorganic phosphates and alkaline phosphatase activity due to anti-ipileptic treatment].
    Schweizerische medizinische Wochenschrift, 1976, Aug-14, Volume: 106, Issue:33

    Topics: Adolescent; Adult; Alkaline Phosphatase; Calcium; Clinical Trials as Topic; Epilepsy; Female; Humans

1976
Carbamazepine (Tegretol) as an anticonvulsant. A controlled double-blind comparison with diphenylhydantoin (Dilantin).
    Acta neurologica Scandinavica. Supplementum, 1975, Volume: 60

    Topics: Adult; Carbamazepine; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Epile

1975
Controlled trial of sodium valproate in severe epilepsy.
    British medical journal, 1975, Nov-01, Volume: 4, Issue:5991

    Topics: Adult; Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Epilepsy; Female; Humans; Male;

1975
The efficacy of carbamazepine combinations in epilepsy.
    Clinical pharmacology and therapeutics, 1975, Volume: 18, Issue:6

    Topics: Adult; Biological Availability; Carbamazepine; Clinical Trials as Topic; Drug Administration Schedul

1975
Anticonvulsants in the treatment of aggression.
    The Journal of nervous and mental disease, 1975, Volume: 160, Issue:2-1

    Topics: Adult; Aggression; Anticonvulsants; Chlordiazepoxide; Chlorpromazine; Drug Therapy, Combination; Epi

1975
Cognitive effects of oxcarbazepine and phenytoin monotherapy in newly diagnosed epilepsy: one year follow-up.
    Epilepsy research, 1992, Volume: 11, Issue:3

    Topics: Adult; Anticonvulsants; Attention; Carbamazepine; Cognition; Double-Blind Method; Epilepsy; Female;

1992
Do prophylactic anticonvulsant drugs alter the pattern of seizures after craniotomy?
    Journal of neurology, neurosurgery, and psychiatry, 1992, Volume: 55, Issue:9

    Topics: Actuarial Analysis; Adolescent; Adult; Aged; Brain Diseases; Carbamazepine; Craniotomy; Dose-Respons

1992
Effects of withdrawal of phenytoin on cognitive and psychomotor functions in hospitalized epileptic patients on polytherapy.
    Acta neurologica Scandinavica, 1992, Volume: 86, Issue:2

    Topics: Adult; Anticonvulsants; Attention; Cognition; Dose-Response Relationship, Drug; Drug Therapy, Combin

1992
Bioavailability and dissolution of proprietary and generic formulations of phenytoin.
    Journal of neurology, neurosurgery, and psychiatry, 1992, Volume: 55, Issue:8

    Topics: Adolescent; Adult; Biological Availability; Dose-Response Relationship, Drug; Drug Administration Sc

1992
Clinical trial on sustained-release phenytoin. Preliminary results of the open, non-controlled study. The Phenytoin Trial Group on Canine Epilepsy.
    Tijdschrift voor diergeneeskunde, 1992, Volume: 117 Suppl 1

    Topics: Animals; Delayed-Action Preparations; Dog Diseases; Dogs; Epilepsy; Phenytoin

1992
The administration of folic acid to institutionalized epileptic adults with phenytoin-induced gingival hyperplasia. A double-blind, randomized, placebo-controlled, parallel study.
    Oral surgery, oral medicine, and oral pathology, 1991, Volume: 71, Issue:5

    Topics: Adult; Dental Care for Disabled; Dental Plaque Index; Double-Blind Method; Epilepsy; Female; Folic A

1991
Cognitive impairment in new cases of epilepsy randomly assigned to carbamazepine, phenytoin and sodium valproate.
    Developmental medicine and child neurology, 1991, Volume: 33, Issue:6

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cognition; Epilepsy; Humans; In

1991
Discontinuation of antiepileptic drugs in children who have outgrown epilepsy: effects on cognitive function.
    Epilepsia, 1990, Volume: 31 Suppl 4

    Topics: Adolescent; Anticonvulsants; Attention; Carbamazepine; Child; Cognition; Epilepsy; Ethosuximide; Hum

1990
[Clinical and experimental control of optimal therapy in epilepsy].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1990, Volume: 42, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Neurocognitive Disorder

1990
Comparative cognitive effects of anticonvulsants.
    Neurology, 1990, Volume: 40, Issue:3 Pt 1

    Topics: Adult; Anticonvulsants; Carbamazepine; Cognition; Epilepsy; Female; Humans; Male; Middle Aged; Neuro

1990
A comparative bioavailability of 2 oral solid phenytoin dosage forms.
    The Central African journal of medicine, 1989, Volume: 35, Issue:4

    Topics: Administration, Oral; Adult; Biological Availability; Epilepsy; Female; Humans; Male; Phenytoin; Ran

1989
A multicentre study of vigabatrin for drug-resistant epilepsy.
    British journal of clinical pharmacology, 1989, Volume: 27 Suppl 1

    Topics: Adult; Aged; Aminocaproates; Anticonvulsants; Clinical Trials as Topic; Drug Resistance; Epilepsy; F

1989
Phenytoin prodrug: preclinical and clinical studies.
    Epilepsia, 1989, Volume: 30 Suppl 2

    Topics: Adult; Aged; Clinical Trials as Topic; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Place

1989
Folate treatment of diphenylhydantoin-induced gingival hyperplasia.
    Scandinavian journal of dental research, 1989, Volume: 97, Issue:3

    Topics: Adolescent; Child; Epilepsy; Female; Folic Acid; Gingival Hyperplasia; Humans; Intellectual Disabili

1989
Compliant populations: variability in serum concentrations.
    Epilepsy research. Supplement, 1988, Volume: 1

    Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combina

1988
Serum levels of sodium valproate, phenytoin and carbamazepine and seizure control in epilepsy.
    Irish medical journal, 1986, Volume: 79, Issue:6

    Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Fema

1986
A comparative study of progabide, valproate, and placebo as add-on therapy in patients with refractory epilepsy.
    Journal of neurology, neurosurgery, and psychiatry, 1986, Volume: 49, Issue:11

    Topics: Adolescent; Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug

1986
Withdrawal of anticonvulsant drugs in patients free of seizures for two years. A prospective study.
    The New England journal of medicine, 1988, Apr-14, Volume: 318, Issue:15

    Topics: Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies, Par

1988
Withdrawal symptoms from phenytoin, carbamazepine and sodium valproate.
    Journal of neurology, neurosurgery, and psychiatry, 1988, Volume: 51, Issue:7

    Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy,

1988
Aspects of compliance: taking drugs and keeping clinic appointments.
    Epilepsy research. Supplement, 1988, Volume: 1

    Topics: Adolescent; Adult; Anticonvulsants; Appointments and Schedules; Carbamazepine; Clinical Trials as To

1988
Results of a nationwide Veterans Administration Cooperative Study comparing the efficacy and toxicity of carbamazepine, phenobarbital, phenytoin, and primidone.
    Epilepsia, 1987, Volume: 28 Suppl 3

    Topics: Adult; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epilepsy; Humans; Phenobarbital

1987
Progabide for refractory partial epilepsy: a controlled add-on trial.
    Neurology, 1986, Volume: 36, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Double-Blind Meth

1986
Single-dose oral phenytoin loading.
    Annals of emergency medicine, 1987, Volume: 16, Issue:4

    Topics: Administration, Oral; Adult; Aged; Capsules; Drug Administration Schedule; Epilepsy; Female; Humans;

1987
Which drug for the adult epileptic patient: phenytoin or valproate?
    British medical journal (Clinical research ed.), 1985, Mar-16, Volume: 290, Issue:6471

    Topics: Adolescent; Adult; Aged; Body Weight; Clinical Trials as Topic; Epilepsies, Partial; Epilepsy; Femal

1985
Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures.
    The New England journal of medicine, 1985, Jul-18, Volume: 313, Issue:3

    Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epilepsies, P

1985
[Efficient serum concentrations after single doses of antiepileptic drugs: concept of loading-dose].
    Arquivos de neuro-psiquiatria, 1985, Volume: 43, Issue:1

    Topics: Absorption; Administration, Oral; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epil

1985
Influence of folic acid on blood-phenytoin levels.
    Lancet (London, England), 1971, Jan-09, Volume: 1, Issue:7689

    Topics: Adult; Anticonvulsants; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Male; Phenobarbital; Ph

1971
Electroencephalographic investigations during evaluation of the antiepileptic agent sulthiame.
    Epilepsia, 1974, Volume: 15, Issue:1

    Topics: Anticonvulsants; Clinical Trials as Topic; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe

1974
Sulthiame: evaluation as an anticonvulsant.
    Epilepsia, 1974, Volume: 15, Issue:3

    Topics: Anticonvulsants; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Evaluation; Electr

1974
Relation of abnormal folate metabolism to neuropathy developing during anticonvulsant drug therapy.
    Lancet (London, England), 1968, Mar-16, Volume: 1, Issue:7542

    Topics: Adolescent; Adult; Anticonvulsants; Biological Assay; Child; Electrodiagnosis; Electromyography; Epi

1968
Evaluation of albutoin as an antiepileptic drug.
    Clinical pharmacology and therapeutics, 1974, Volume: 15, Issue:4

    Topics: Adolescent; Adult; Allyl Compounds; Analysis of Variance; Anticonvulsants; Appetite; Biopharmaceutic

1974
"Anticonvulsant action" of vitamin D in epileptic patients? A controlled pilot study.
    British medical journal, 1974, May-04, Volume: 2, Issue:5913

    Topics: Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Calcium; Child; Clinical Trials as Topic;

1974
Carbamazepine for epilepsy. A controlled prospective evaluation.
    Neurology, 1974, Volume: 24, Issue:5

    Topics: Adult; Blood Cell Count; Bone Marrow Diseases; Carbamazepine; Clinical Trials as Topic; Electroencep

1974
Gingival hyperplasia related to treatment with diphenylhydantoin (diphedan; DH).
    Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1969, Volume: 2, Issue:2

    Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Child; Child, Presc

1969
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
    Epilepsia, 1969, Volume: 10, Issue:2

    Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials

1969
Drug--interaction between sulthiame (Ospolot (R)) and phenytoin in the treatment of epilepsy.
    Danish medical bulletin, 1969, Volume: 16, Issue:5

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Thiazines; Time Fa

1969
Blood phenytoin concentrations produced by ingestion of three different phenytoin preparations.
    The Medical journal of Australia, 1972, Feb-26, Volume: 1, Issue:9

    Topics: Adolescent; Adult; Calcium; Clinical Trials as Topic; Drug Compounding; Epilepsy; Epilepsy, Temporal

1972
Effect of chronic anticonvulsant therapy on serum 25-hydroxycalciferol levels in adults.
    The New England journal of medicine, 1972, Nov-02, Volume: 287, Issue:18

    Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Calcium; Clinical Trials as Topic; Epilepsy; Ergocalci

1972
Effect of vitamin D on bone mineral mass in normal subjects and in epileptic patients on anticonvulsants: a controlled therapeutic trial.
    British medical journal, 1973, Apr-28, Volume: 2, Issue:5860

    Topics: Absorption; Adult; Bone and Bones; Calcium; Clinical Trials as Topic; Epilepsy; Female; Humans; Ligh

1973
Folate therapy in epilepsy. A controlled study.
    Archives of neurology, 1973, Volume: 29, Issue:2

    Topics: Clinical Trials as Topic; Cognition; Epilepsy; Evaluation Studies as Topic; Folic Acid; Humans; Leuc

1973
[Short report on the effect of the anticonvulsant Ro 5-4023 (clonazepam) in different forms of epilepsy].
    Acta neurologica Scandinavica. Supplementum, 1973, Volume: 53

    Topics: Adolescent; Anticonvulsants; Barbiturates; Benzodiazepinones; Carbamazepine; Child; Child, Preschool

1973
Cerebrospinal folate levels in epileptics and their response to folate therapy.
    Nutrition reviews, 1974, Volume: 32, Issue:3

    Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Def

1974
Clonazepam--a clinical study of its effectiveness as an anticonvulsant.
    Proceedings of the Australian Association of Neurologists, 1973, Volume: 10, Issue:0

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepinones; Child; Child, Preschool; Chlorobenzenes; Clin

1973
Renal insensitivity to frusemide caused by chronic anticonvulsant therapy.
    British medical journal, 1974, Sep-14, Volume: 3, Issue:5932

    Topics: Administration, Oral; Adult; Anticonvulsants; Clinical Trials as Topic; Diuresis; Drug Interactions;

1974
Effect of vitamin D2 on serum phenytoin. A controlled therapeutical trial.
    Acta neurologica Scandinavica, 1974, Volume: 50, Issue:5

    Topics: Adult; Aged; Clinical Trials as Topic; Drug Interactions; Epilepsy; Ergocalciferols; Female; Humans;

1974
Incidence of anticonvulsant osteomalacia and effect of vitamin D: controlled therapeutic trial.
    British medical journal, 1973, Dec-22, Volume: 4, Issue:5894

    Topics: Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Bone and Bones; Calcium; Creatinine; Epilepsy; F

1973
Behavioral effects of diphenylhydantoin in severe psychiatric disorders.
    The American journal of psychiatry, 1967, Volume: 124, Issue:6

    Topics: Adolescent; Adult; Character; Child; Clinical Trials as Topic; Electroencephalography; Epilepsy; Fem

1967
The psychoactive properties of diphenylhydantoin: experiences with prisoners and juvenile delinquents.
    International journal of neuropsychiatry, 1967, Volume: 3

    Topics: Adolescent; Adult; Affect; Child; Child Behavior Disorders; Clinical Trials as Topic; Criminal Psych

1967
Subnormal serum folate due to anticonvulsive therapy. A double-blind study of the effect of folic acid treatment in patients with drug-induced subnormal serum folates.
    Archives of neurology, 1970, Volume: 22, Issue:2

    Topics: Adult; Anticonvulsants; Clinical Trials as Topic; Epilepsy; Erythrocyte Count; Female; Folic Acid; H

1970
[Clinical pharmacology (13): therapy control. Discussion introduction].
    Lakartidningen, 1970, Apr-29, Volume: 67, Issue:18

    Topics: Clinical Trials as Topic; Drug Therapy; Epilepsy; Humans; Phenytoin; Thyroxine

1970
Evaluation of folic acid supplements in children taking phenytoin.
    Developmental medicine and child neurology, 1971, Volume: 13, Issue:3

    Topics: Adolescent; Child; Child Behavior Disorders; Clinical Trials as Topic; Electroencephalography; Epile

1971
A survey of 156 seizure patients in a general pediatric clinic.
    The Journal-lancet, 1966, Volume: 86, Issue:3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Epilepsy; Epilepsy,

1966
Acute treatment of epileptic seizures with diazepamum (Valium).
    Acta neurologica Scandinavica, 1967, Volume: 43, Issue:S31

    Topics: Acute Disease; Adolescent; Adult; Aged; Aphasia; Clinical Trials as Topic; Diazepam; Epilepsy; Epile

1967
Diphenylhydantoin as an anticonvulsant: evaluation of treatment in forty mentally subnormal epileptics.
    Journal of mental deficiency research, 1969, Volume: 13, Issue:3

    Topics: Adolescent; Adult; Chlorpromazine; Clinical Trials as Topic; Electroencephalography; Epilepsies, Par

1969
Relative anticonvulsant potency of primidone; a double blind comparison.
    Archives of neurology, 1966, Volume: 14, Issue:1

    Topics: Clinical Trials as Topic; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Primidone

1966
Studies on the metabolism of phenytoin.
    Epilepsia, 1966, Volume: 7, Issue:3

    Topics: Clinical Trials as Topic; Electroencephalography; Epilepsy; Humans; Phenytoin

1966
Phenytoin intoxication during treatment with antabuse (Disulfiram).
    Epilepsia, 1966, Volume: 7, Issue:3

    Topics: Adult; Alcoholism; Clinical Trials as Topic; Disulfiram; Drug Compounding; Drug Incompatibility; Epi

1966
The influence of phenobarbital on the half-life of diphenylhydantoin in man.
    Acta medica Scandinavica, 1969, Volume: 185, Issue:4

    Topics: Adolescent; Adult; Aged; Carbon Isotopes; Enzyme Induction; Epilepsy; Humans; Metabolic Clearance Ra

1969

Other Studies

2159 other studies available for phenytoin and Aura

ArticleYear
Functionalized DL-amino acid derivatives. Potent new agents for the treatment of epilepsy.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:3

    Topics: Amino Acids; Animals; Anticonvulsants; Epilepsy; Magnetic Resonance Spectroscopy; Male; Mice; Seizur

1987
Structure-activity relationships of phenytoin-like anticonvulsant drugs.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:1

    Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Electroshock; Epilepsy; Magnetic Resonance S

1984
Synthesis and evaluation of N-(phenylacetyl)trifluoromethanesulfonamides as anticonvulsant agents.
    Journal of medicinal chemistry, 1996, Mar-29, Volume: 39, Issue:7

    Topics: Animals; Anticonvulsants; Body Weight; Cytochrome P-450 Enzyme System; Epilepsy; Mesylates; Mice; NA

1996
Newer GABA derivatives for the treatment of epilepsy including febrile seizures: a bioisosteric approach.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:12

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Dru

2008
Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:6

    Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Drug Synergism; Epilepsy; Liver; Mice; Nervo

2010
Combating oxidative stress in epilepsy: design, synthesis, quantum chemical studies and anticonvulsant evaluation of 1-(substituted benzylidene/ethylidene)-4-(naphthalen-1-yl)semicarbazides.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:7

    Topics: Animals; Anticonvulsants; Antioxidants; Benzylidene Compounds; Drug Design; Electrons; Epilepsy; Mal

2010
Synthesis and anticonvulsant activity of new 6-methyl-1-substituted-4,6-diazaspiro[2.4]heptane-5,7-diones.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:9

    Topics: Animals; Anticonvulsants; Electroshock; Epilepsy; Heptanes; Male; Mice; Pentylenetetrazole; Structur

2010
Synthesis and anticonvulsant activity of novel 2,6-diketopiperazine derivatives. Part 1: perhydropyrrole[1,2-a]pyrazines.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:10

    Topics: Animals; Anticonvulsants; Diketopiperazines; Electroshock; Epilepsy; Humans; Male; Mice; Models, Mol

2011
Design, synthesis and antiepileptic properties of novel 1-(substituted benzylidene)-3-(1-(morpholino/piperidino methyl)-2,3-dioxoindolin-5-yl)urea derivatives.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:12

    Topics: Animals; Anticonvulsants; Electroshock; Epilepsy; Humans; Isatin; Male; Mice; Morpholinos; Piperidin

2011
Design, synthesis and anticonvulsant evaluation of novel N-(4-substituted phenyl)-2-[4-(substituted) benzylidene]-hydrazinecarbothio amides.
    European journal of medicinal chemistry, 2012, Volume: 47, Issue:1

    Topics: Animals; Anticonvulsants; Drug Design; Epilepsy; Hydrogen Bonding; Male; Mice; Models, Molecular; Pr

2012
Synthesis and anticonvulsant activity of novel 2,6-diketopiperazine derivatives. Part 2: Perhydropyrido[1,2-a]pyrazines.
    European journal of medicinal chemistry, 2012, Volume: 48

    Topics: Animals; Anticonvulsants; Biological Assay; Diketopiperazines; Electroshock; Epilepsy; Magnetic Reso

2012
Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).
    Journal of medicinal chemistry, 2013, Nov-27, Volume: 56, Issue:22

    Topics: Absorption; Amides; Animals; Anticonvulsants; Dioxanes; Dogs; Drug Evaluation, Preclinical; Drug Res

2013
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
    Bioorganic & medicinal chemistry, 2014, Oct-01, Volume: 22, Issue:19

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ep

2014
Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents.
    Bioorganic & medicinal chemistry letters, 2015, Mar-01, Volume: 25, Issue:5

    Topics: Animals; Anticonvulsants; Carbamates; Drug Design; Electroshock; Epilepsy; Mice; Pentylenetetrazole;

2015
Discovery of benzothiazine derivatives as novel, orally-active anti-epileptic drug candidates with broad anticonvulsant effect.
    Bioorganic & medicinal chemistry letters, 2015, Oct-15, Volume: 25, Issue:20

    Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship,

2015
Electronic Health Record Interoperability-Why Electronically Discontinued Medications Are Still Dispensed.
    JAMA internal medicine, 2021, 10-01, Volume: 181, Issue:10

    Topics: Accidental Falls; Aged; Anticonvulsants; Clinical Pharmacy Information Systems; Deprescriptions; Dru

2021
The epilepsy-movement disorder phenotypic spectrum and phenytoin-induced dyskinesia associated with GABRB3 pathogenic variants.
    Epileptic disorders : international epilepsy journal with videotape, 2021, Dec-01, Volume: 23, Issue:6

    Topics: Dyskinesia, Drug-Induced; Epilepsy; Humans; Movement Disorders; Phenytoin; Receptors, GABA-A

2021
Patient, Disease, and Drug-Related Risk Factors Associated with Phenytoin- Induced Cutaneous Adverse Drug Reactions in South Indian Epileptic Patients - A Prospective Case-Control Study.
    Current drug safety, 2022, Volume: 17, Issue:3

    Topics: Adult; Anticonvulsants; Case-Control Studies; Drug-Related Side Effects and Adverse Reactions; Epile

2022
Use of Saliva as an Alternative Matrix to Serum/Plasma for Therapeutic Drug Monitoring Using Reverse-Phase HPLC.
    Clinical therapeutics, 2021, Volume: 43, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Drug Monitoring; Epilepsy; Hum

2021
Nesfatin-1 ameliorates oxidative brain damage and memory impairment in rats induced with a single acute epileptic seizure.
    Life sciences, 2022, Apr-01, Volume: 294

    Topics: Animals; Anticonvulsants; Brain Injuries; Epilepsy; Glutathione; Male; Memory Disorders; Neuroprotec

2022
Incidence of Antiseizure Medication-Induced Severe Cutaneous Adverse Reactions in Malaysia.
    Journal of clinical pharmacology, 2022, Volume: 62, Issue:8

    Topics: Anticonvulsants; Drug Eruptions; Epilepsy; HLA Antigens; Humans; Incidence; Lamotrigine; Malaysia; P

2022
Clinical Evaluation of Levetiracetam in the Treatment of Epilepsy.
    Journal of healthcare engineering, 2022, Volume: 2022

    Topics: Anticonvulsants; Epilepsy; Humans; Levetiracetam; Phenytoin; Valproic Acid

2022
Exome sequencing allows detection of relevant pharmacogenetic variants in epileptic patients.
    The pharmacogenomics journal, 2022, Volume: 22, Issue:5-6

    Topics: Epilepsy; Exome; Humans; Pharmacogenomic Variants; Phenytoin; Retrospective Studies

2022
The treatment of epilepsy in younger and older adults: Demographic differences and prescribing patterns of anti-seizure medications in Canada.
    Epilepsy research, 2022, Volume: 184

    Topics: Aged; Anticonvulsants; Comorbidity; Demography; Drug Prescriptions; Epilepsy; Female; Humans; Male;

2022
Multimorbidity and chronic co-prescription networks and potential interactions in adult patients with epilepsy: MorbiNet study.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022, Volume: 43, Issue:12

    Topics: Adult; Comorbidity; Dementia; Epilepsy; Humans; Multimorbidity; Phenytoin; Prescriptions

2022
Long-Term Effects of Antiseizure Medications.
    Seminars in neurology, 2022, Volume: 42, Issue:5

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenytoin; Seizures

2022
Trimetazidine, an Anti-Ischemic Drug, Reduces the Antielectroshock Effects of Certain First-Generation Antiepileptic Drugs.
    International journal of molecular sciences, 2022, Sep-26, Volume: 23, Issue:19

    Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res

2022
Ranolazine Interacts Antagonistically with Some Classical Antiepileptic Drugs-An Isobolographic Analysis.
    Molecules (Basel, Switzerland), 2022, Dec-15, Volume: 27, Issue:24

    Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res

2022
A real-life pilot study of the clinical application of pharmacogenomics testing on saliva in epilepsy.
    Epilepsia open, 2023, Volume: 8, Issue:3

    Topics: Anticonvulsants; Clobazam; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C

2023
Calcium Phosphate-Based Nanoformulation Selectively Abolishes Phenytoin Resistance in Epileptic Neurons for Ceasing Seizures.
    Small (Weinheim an der Bergstrasse, Germany), 2023, Volume: 19, Issue:29

    Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Phosphates; Epilep

2023
ROS/Electro Dual-Reactive Nanogel for Targeting Epileptic Foci to Remodel Aberrant Circuits and Inflammatory Microenvironment.
    ACS nano, 2023, 04-25, Volume: 17, Issue:8

    Topics: Anticonvulsants; Epilepsy; Humans; Nanogels; Phenytoin; Reactive Oxygen Species

2023
Valproate-related hyperammonemic encephalopathy with generalized suppression EEG: a case report.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023, Volume: 44, Issue:10

    Topics: Adult; Anticonvulsants; Brain Diseases; Electroencephalography; Epilepsy; Female; Humans; Hyperammon

2023
External validation of the AntiEpileptic Drug Monitoring in PREgnancy (EMPiRE) model for predicting seizures in pregnant women with epilepsy.
    BMC pregnancy and childbirth, 2023, Jul-11, Volume: 23, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Cohort Studies; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam

2023
Evolution of antiseizure medication use and cost in the United States of America 2006-2021.
    Seizure, 2023, Volume: 112

    Topics: Adult; Anticonvulsants; Child; Drugs, Generic; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam;

2023
Antiepileptic drug-induced psychosis associated with MTHFR C677T: a case report.
    Journal of medical case reports, 2019, Aug-12, Volume: 13, Issue:1

    Topics: Adolescent; Anticonvulsants; Avitaminosis; Epilepsy; Humans; Male; Methylenetetrahydrofolate Reducta

2019
An infant with epilepsy: don't forget the importance of skin examination.
    BMJ case reports, 2019, Aug-26, Volume: 12, Issue:8

    Topics: Anticonvulsants; Diagnosis, Differential; Epilepsy; Female; Hemimegalencephaly; Humans; Hypopigmenta

2019
Elevated serum alkaline phosphatase in epilepsy: effect of age and treatment.
    British journal of biomedical science, 2020, Volume: 77, Issue:1

    Topics: Adolescent; Adult; Age Factors; Alkaline Phosphatase; Anticonvulsants; Carbamazepine; Child; Child,

2020
Hippocampal low-frequency stimulation improves cognitive function in pharmacoresistant epileptic rats.
    Epilepsy research, 2020, Volume: 168

    Topics: Animals; Anticonvulsants; Cognition; Disease Models, Animal; Electric Stimulation; Epilepsy; Hippoca

2020
Budget Impact Analysis of Extended-Release Phenytoin Capsules Compared With Immediate-Release Phenytoin Capsules for Patients With Epilepsy in Thailand.
    Value in health regional issues, 2020, Volume: 21

    Topics: Anticonvulsants; Capsules; Delayed-Action Preparations; Epilepsy; Humans; National Health Programs;

2020
Genotoxicity assessment of antiepileptic drugs (AEDs) in human embryonic stem cells.
    Epilepsy research, 2019, Volume: 158

    Topics: Anticonvulsants; Carbamazepine; DNA Damage; Epilepsy; Female; Human Embryonic Stem Cells; Humans; La

2019
Levetiracetam is a useful alternative to phenytoin for epileptic seizures in children.
    BMJ (Clinical research ed.), 2019, 11-11, Volume: 367

    Topics: Child; Epilepsy; Humans; Levetiracetam; Phenytoin; Seizures; Status Epilepticus

2019
Paradoxical deterioration in seizure control due to anticonvulsant-induced hypocalcaemia.
    BMJ case reports, 2019, Dec-05, Volume: 12, Issue:12

    Topics: Anticonvulsants; Diagnosis, Differential; Epilepsy; Humans; Hypocalcemia; Male; Middle Aged; Phenyto

2019
Drug therapy problems and treatment satisfaction among ambulatory patients with epilepsy in a specialized hospital in Ethiopia.
    PloS one, 2020, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Ambulatory Care Facilities; Anticonvulsants; Cross-Sectional Studies; Drug Intera

2020
Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice.
    Epilepsy & behavior : E&B, 2020, Volume: 103, Issue:Pt A

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anticonvulsants; Corticosterone; Depression; Dose-

2020
Diagnostic evaluation and management of seizures and status epilepticus in children with known epilepsy or new-onset seizures: A retrospective and comparative analysis.
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2020, Volume: 27, Issue:2

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clonazepam; Diazepam; Epilepsy; Female; Hospit

2020
Nanocage encapsulation improves antiepileptic efficiency of phenytoin.
    Biomaterials, 2020, Volume: 240

    Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri

2020
Patterns of antiepileptic drug use among elderly patients with epilepsy: 2004-2015.
    Epilepsy research, 2020, Volume: 161

    Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Epilepsy; F

2020
Refractory Bullous Pemphigoid Improved by Discontinuation of Phenytoin as an CYP3A4 Inducer.
    Acta dermato-venereologica, 2020, 04-06, Volume: 100, Issue:8

    Topics: Aged; Anti-Inflammatory Agents; Anticonvulsants; Cerebral Palsy; Cytochrome P-450 CYP3A Inducers; Dr

2020
Influence of dose and antiepileptic comedication on brivaracetam serum concentrations in patients with epilepsy.
    Epilepsia, 2020, Volume: 61, Issue:5

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dibenzazepines; Drug Interactions; D

2020
Paediatric status epilepticus: finally, some evidence-based treatment guidance, but still a long way to go.
    The Lancet. Child & adolescent health, 2020, Volume: 4, Issue:5

    Topics: Adolescent; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Emergency Treatment; Epilepsy

2020
Effects of antiepileptic drugs on electroencephalography (EEG): Insights and applicability.
    Epilepsy & behavior : E&B, 2020, Volume: 110

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Electroencephalography; Epilepsy

2020
Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database.
    Epilepsia, 2020, Volume: 61, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Clobazam; Clonazepam; Databases, Factual; Drug Therapy, Combination;

2020
Therapeutic Monitoring of Lacosamide in Japanese Patients With Epilepsy: Clinical Response, Tolerability, and Optimal Therapeutic Range.
    Therapeutic drug monitoring, 2020, Volume: 42, Issue:5

    Topics: Adult; Anticonvulsants; Asian People; Carbamazepine; Drug Interactions; Drug Monitoring; Drug Therap

2020
Influenza immunization does not predominantly alter levels of phenytoin, and cytochrome P-450 enzymes in epileptic patients receiving phenytoin monotherapy.
    Epilepsy research, 2020, Volume: 167

    Topics: Adolescent; Adult; Anticonvulsants; Cytochrome P-450 CYP2C9; Epilepsy; Female; Genotype; Humans; Imm

2020
Pharmacokinetics, tolerability, and clinical effectiveness of perampanel in Japanese patients with epilepsy.
    Seizure, 2020, Volume: 83

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Drug Monitoring; Drug T

2020
Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine.
    British journal of clinical pharmacology, 2021, Volume: 87, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Epoxide Hydrolases; Humans; Phenytoin

2021
Developing precision treatments for epilepsy using patient and animal models.
    Expert review of neurotherapeutics, 2021, Volume: 21, Issue:11

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Humans; Lamotrigine; Phenytoin

2021
Potential induction of epileptic spasms by nonselective voltage-gated sodium channel blockade: Interaction with etiology.
    Epilepsy & behavior : E&B, 2021, Volume: 115

    Topics: Anticonvulsants; Child; Epilepsy; Humans; Phenytoin; Spasm; Spasms, Infantile; Voltage-Gated Sodium

2021
Gingival overgrowth induced by anticonvulsant drugs: A cross-sectional study on epileptic patients.
    Journal of periodontal research, 2021, Volume: 56, Issue:2

    Topics: Anticonvulsants; Cross-Sectional Studies; Epilepsy; Female; Gingival Overgrowth; Humans; Male; Pheny

2021
Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats.
    Journal of ethnopharmacology, 2021, Apr-24, Volume: 270

    Topics: Adjuvants, Pharmaceutic; Animals; Anticonvulsants; Behavior, Animal; Centella; Cognitive Dysfunction

2021
Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice.
    Pharmacology, biochemistry, and behavior, 2021, Volume: 201

    Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship,

2021
Gene Expression Analysis Identifies Cholesterol Metabolism Dysregulation in Hippocampus of Phenytoin-Resistant Pentylenetetrazol-Kindled Epileptic Mice.
    Neuromolecular medicine, 2021, Volume: 23, Issue:4

    Topics: Animals; Anticonvulsants; Cholesterol; Epilepsy; Gene Expression; Hippocampus; Humans; Kindling, Neu

2021
To determine the effect of long-term antiepileptic drug on the serum folate and vitamin B12 among epileptic patients.
    Scientific reports, 2021, 02-23, Volume: 11, Issue:1

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Folic Acid; Humans; Male; Middle Aged; Phenytoin; Vitamin

2021
Effects of antiepileptic drugs' administration during pregnancy on the nerve cell proliferation and axonal outgrowth of human neuroblastoma SH-SY5Y nerve cells.
    Biochemical and biophysical research communications, 2021, 05-21, Volume: 554

    Topics: Anticonvulsants; Carbamazepine; Cell Line, Tumor; Cell Proliferation; Child; Epilepsy; Female; Human

2021
Post-stroke epilepsy and antiepileptic drug use in men and women.
    Basic & clinical pharmacology & toxicology, 2021, Volume: 129, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Lamotrigin

2021
pH-induced homogeneous liquid-liquid microextraction method based on new switchable deep eutectic solvent for the extraction of three antiepileptic drugs from breast milk.
    Bioanalysis, 2021, Volume: 13, Issue:14

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Hydrogen-Ion Concentration; Lamotrigine; Liquid Phase Mic

2021
Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency.
    Epilepsia, 2021, Volume: 62, Issue:9

    Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsy; Levetiracetam; Pharmaceut

2021
Lack of pathogenic mutations in SOS1 gene in phenytoin-induced gingival overgrowth patients.
    Archives of oral biology, 2017, Volume: 80

    Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Chromatography, High Pressure Liquid; Epil

2017
Fetal Hydantoin Syndrome.
    The Journal of pediatrics, 2017, Volume: 188

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Administration, Oral; Epilepsy; Female; Humans

2017
Phenytoin Toxicity.
    JAMA, 2017, Jun-20, Volume: 317, Issue:23

    Topics: Airway Extubation; Anticonvulsants; Drug Administration Schedule; Epilepsy; Humans; Lung Diseases, O

2017
Fosphenytoin-induced purple glove syndrome: A case report.
    Clinical neurology and neurosurgery, 2017, Volume: 160

    Topics: Aged; Anticonvulsants; Edema; Epilepsy; Humans; Male; Phenytoin; Skin Diseases; Upper Extremity

2017
Risk of angioedema associated with levetiracetam compared with phenytoin: Findings of the observational health data sciences and informatics research network.
    Epilepsia, 2017, Volume: 58, Issue:8

    Topics: Angioedema; Community Networks; Databases, Factual; Epilepsy; Female; Humans; Levetiracetam; Male; P

2017
Homocysteine Metabolism and Hematological Parameters in Early Stage of Phenytoin Treated Epileptic Children.
    Clinical laboratory, 2017, Jul-01, Volume: 63, Issue:7

    Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Phe

2017
Drug rash with eosinophilia and systemic symptoms (DRESS) caused by phenytoin.
    BMJ case reports, 2017, Aug-22, Volume: 2017

    Topics: Adult; Anti-Inflammatory Agents; Anticonvulsants; Diagnosis, Differential; Drug Hypersensitivity Syn

2017
Preliminary study of the association between the elimination parameters of phenytoin and phenobarbital.
    Drug metabolism and personalized therapy, 2017, 09-26, Volume: 32, Issue:3

    Topics: Adult; Anticonvulsants; Drug Monitoring; Epilepsy; Female; Humans; Linear Models; Male; Middle Aged;

2017
Evaluation of phenytoin serum levels following a loading dose in the acute hospital setting.
    Seizure, 2017, Volume: 52

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Community Health Planning; Epile

2017
Effects of the Antiepileptic Drugs Phenytoin, Gabapentin, and Levetiracetam on Bone Strength, Bone Mass, and Bone Turnover in Rats.
    Biological & pharmaceutical bulletin, 2017, Volume: 40, Issue:11

    Topics: Administration, Oral; Amines; Animals; Anticonvulsants; Bone Density; Bone Remodeling; Bone Resorpti

2017
Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:6

    Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Avoidance Learning; Brain; Disease Models, Animal;

2017
Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018, Jan-15, Volume: 112

    Topics: Acetaminophen; Animals; Biological Transport; Brain; Brain Injuries, Traumatic; Central Nervous Syst

2018
Phenytoin-related ataxia in patients with epilepsy: clinical and radiological characteristics.
    Seizure, 2018, Volume: 56

    Topics: Antibodies; Anticonvulsants; Ataxia; Brain; Epilepsy; Female; Folic Acid; Gliadin; GTP-Binding Prote

2018
Therapeutic Drug Monitoring of Phenytoin by Simple, Rapid, Accurate, Highly Sensitive and Novel Method and Its Clinical Applications.
    Current pharmaceutical biotechnology, 2017, Volume: 18, Issue:13

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Chromatography, Liquid; Drug Moni

2017
Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry.
    The Lancet. Neurology, 2018, Volume: 17, Issue:6

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug

2018
The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy.
    Epilepsia, 2018, Volume: 59, Issue:6

    Topics: Action Potentials; Animals; Anticonvulsants; Brain Diseases; Disease Models, Animal; Drug Administra

2018
Incidence of Stevens-Johnson syndrome following combination drug use of allopurinol, carbamazepine and phenytoin in Taiwan: A case-control study.
    The Journal of dermatology, 2018, Volume: 45, Issue:9

    Topics: Adult; Aged; Allopurinol; Anticonvulsants; Carbamazepine; Case-Control Studies; Drug Combinations; E

2018
Phenytoin induced dystonia.
    The Turkish journal of pediatrics, 2018, Volume: 60, Issue:1

    Topics: Anticonvulsants; Child, Preschool; Dystonia; Epilepsy; Humans; Male; Phenytoin; Primidone

2018
Evaluation of a lymphocyte transformation test and cytokine detection assay to identify phenytoin and carbamazepine provoked DRESS or SJS/TEN in epilepsy patients.
    International immunopharmacology, 2018, Volume: 63

    Topics: Adult; Anticonvulsants; Carbamazepine; Cytokines; Drug Hypersensitivity Syndrome; Epilepsy; Female;

2018
Frequency of drug combinations between enzyme-inducing first-generation antiepileptic drugs and inducible drugs in patients with epilepsy.
    Epilepsy & behavior : E&B, 2018, Volume: 87

    Topics: Anticonvulsants; Carbamazepine; Cytochrome P-450 Enzyme Inducers; Drug Interactions; Drug Therapy, C

2018
Levetiracetam Induced Neuropsychiatric Manifestation in a 5-year-old Boy.
    Indian journal of pediatrics, 2019, Volume: 86, Issue:2

    Topics: Anticonvulsants; Behavior; Child, Preschool; Cognitive Dysfunction; Epilepsy; Humans; Levetiracetam;

2019
Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood-brain barrier model.
    Epilepsia, 2018, Volume: 59, Issue:11

    Topics: Anticonvulsants; Astrocytes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformat

2018
Drug-drug interactions among drugs prescribed for nontuberculous mycobacterial infection and epilepsy: A case report.
    Journal of clinical pharmacy and therapeutics, 2019, Volume: 44, Issue:1

    Topics: Aged; Anti-Bacterial Agents; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; E

2019
Hypothyroidism induced by phenytoin and gabapentin: A Case Report.
    Medicine, 2018, Volume: 97, Issue:43

    Topics: Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobutyric

2018
Evaluation of Intravenous Phenytoin and Fosphenytoin Loading Doses: Influence of Obesity and Sex.
    The Annals of pharmacotherapy, 2019, Volume: 53, Issue:5

    Topics: Administration, Intravenous; Adult; Aged; Anticonvulsants; Body Mass Index; Dose-Response Relationsh

2019
HLA-B*5701 and HLA-B*5801 in an Indian patient with anti-epileptics induced cutaneous adverse drug reactions.
    European journal of clinical pharmacology, 2019, Volume: 75, Issue:4

    Topics: Acute Generalized Exanthematous Pustulosis; Alleles; Anticonvulsants; Carbamazepine; Epilepsy; Genet

2019
Fetal antiepileptic drug exposure and learning and memory functioning at 6 years of age: The NEAD prospective observational study.
    Epilepsy & behavior : E&B, 2019, Volume: 92

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Lamotrigine; Learning; Memor

2019
Effects of Sodium Valproate, Levetiracetam and Phenytoin Therapy on Evoked Potentials in Children with Epilepsy.
    Indian journal of pediatrics, 2019, Volume: 86, Issue:9

    Topics: Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Evoked Potentials; Humans; L

2019
Optimal Dosing Regimen of Phenytoin for Korean Epilepsy Patients: From Premature Babies to the Elderly.
    Journal of pharmaceutical sciences, 2019, Volume: 108, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Body Weight; Child; Child, Preschool; D

2019
Influence of etiology on treatment choices for neonatal seizures: A survey among pediatric neurologists.
    Brain & development, 2019, Volume: 41, Issue:7

    Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infant; Infant,

2019
Pharmacotherapy and electroencephalographic evolution in SCN8A encephalopathy: A case report.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2019, Volume: 118, Issue:8

    Topics: Anticonvulsants; Brain Diseases; Diagnosis, Differential; Electroencephalography; Epilepsy; Humans;

2019
Estimation of Phenytoin Pharmacokinetic Parameters in Saudi Epileptic Patients.
    Pharmacology, 2019, Volume: 104, Issue:1-2

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Biological Variation, Popu

2019
The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure.
    Pharmacology, biochemistry, and behavior, 2019, Volume: 182

    Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling,

2019
Population Pharmacokinetic Analysis of Phenytoin After Intravenous Administration of Fosphenytoin in Adult and Elderly Epileptic Patients.
    Therapeutic drug monitoring, 2019, Volume: 41, Issue:5

    Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Anticonvulsants; Epilepsy; Female; Huma

2019
Uncommon Treatable Genetic Epileptic Encephalopathies.
    Indian pediatrics, 2019, 05-15, Volume: 56, Issue:5

    Topics: Anticonvulsants; Epilepsy; Genetic Markers; Humans; India; Infant; KCNQ2 Potassium Channel; Mutation

2019
Management and attitudes toward patients with epilepsy in general practice: How far have we come in three decades?
    Epilepsy & behavior : E&B, 2019, Volume: 97

    Topics: Adult; Anticonvulsants; Attitude of Health Personnel; Australia; Carbamazepine; Clinical Competence;

2019
FGF12p.Gly112Ser variant as a cause of phenytoin/phenobarbital responsive epilepsy.
    Clinical genetics, 2019, Volume: 96, Issue:3

    Topics: Alleles; Amino Acid Substitution; Anticonvulsants; Child, Preschool; Electroencephalography; Epileps

2019
Risk factors for hyperammonemia in pediatric patients with epilepsy.
    Epilepsia, 2013, Volume: 54, Issue:6

    Topics: Acetazolamide; Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Dose-Response Rela

2013
Multidrug resistance-associated protein 1 decreases the concentrations of antiepileptic drugs in cortical extracellular fluid in amygdale kindling rats.
    Acta pharmacologica Sinica, 2013, Volume: 34, Issue:4

    Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Epilepsy; Extracellular Fluid; Hippocampus

2013
When less is more: a case of phenytoin toxicity.
    BMJ case reports, 2013, Mar-27, Volume: 2013

    Topics: Aged, 80 and over; Anticonvulsants; Epilepsy; Humans; Male; Phenytoin

2013
HLA typing in Brazilian boys with aromatic antiepileptic drug-induced DRESS.
    International journal of clinical pharmacy, 2013, Volume: 35, Issue:3

    Topics: Alleles; Anticonvulsants; Brazil; Carbamazepine; Child; Drug Eruptions; Eosinophilia; Epilepsy; Hist

2013
Phenytoin-induced gingival enlargement: a dental awakening for patients with epilepsy.
    BMJ case reports, 2013, Apr-23, Volume: 2013

    Topics: Adult; Anticonvulsants; Epilepsy; Gingival Hyperplasia; Humans; Male; Phenytoin

2013
Fosphenytoin induced transient pendular nystagmus.
    Journal of the neurological sciences, 2013, Jul-15, Volume: 330, Issue:1-2

    Topics: Anticonvulsants; Brain; Epilepsy; Humans; Infusions, Intravenous; Magnetic Resonance Imaging; Male;

2013
Studies on pharmacokinetic mechanism of phenytoin resistance in refractory epilepsy.
    Journal of pharmaceutical sciences, 2013, Volume: 102, Issue:9

    Topics: Administration, Oral; Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member

2013
Anonychia due to prenatal phenytoin exposure.
    The Journal of the Association of Physicians of India, 2012, Volume: 60

    Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Nails, Malformed; Phenytoin; Pregnancy; Pregnancy

2012
Intravenous phenytoin: a retrospective analysis of Bayesian forecasting versus conventional dosing in patients.
    International journal of clinical pharmacy, 2013, Volume: 35, Issue:5

    Topics: Age Factors; Anticonvulsants; Bayes Theorem; Cohort Studies; Dose-Response Relationship, Drug; Drug

2013
Use of antiepileptic drugs and risk of hypothyroidism.
    Pharmacoepidemiology and drug safety, 2013, Volume: 22, Issue:10

    Topics: Anticonvulsants; Databases, Factual; Epilepsy; Humans; Hypothyroidism; Phenytoin; Risk Factors; Taiw

2013
Noninvasive screening for preclinical atherosclerosis in children on phenytoin or carbamazepine monotherapy: a cross sectional study.
    Epilepsy research, 2013, Volume: 107, Issue:1-2

    Topics: Anticonvulsants; Atherosclerosis; Carbamazepine; Carotid Arteries; Carotid Intima-Media Thickness; C

2013
A case of selective immunoglobulin A deficiency with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.
    International journal of rheumatic diseases, 2014, Volume: 17, Issue:3

    Topics: Antibodies, Antineutrophil Cytoplasmic; Antibodies, Antinuclear; Anticonvulsants; Epilepsy; Female;

2014
All in his head: an unexpected space-occupying lesion.
    The American journal of medicine, 2014, Volume: 127, Issue:2

    Topics: Aged; Anti-Infective Agents; Anticonvulsants; Brain Abscess; Ceftriaxone; Craniotomy; Drainage; Epil

2014
Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation.
    Epilepsia, 2014, Volume: 55, Issue:1

    Topics: Amines; Animals; Anticonvulsants; Astrocytes; Blotting, Western; Carbamazepine; Cells, Cultured; Coc

2014
P-glycoprotein alters blood-brain barrier penetration of antiepileptic drugs in rats with medically intractable epilepsy.
    Drug design, development and therapy, 2013, Volume: 7

    Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri

2013
Drug interaction between phenytoin and valproic acid in a child with refractory epilepsy: a case report.
    Journal of pharmacy practice, 2014, Volume: 27, Issue:2

    Topics: Anticonvulsants; Child; Drug Interactions; Epilepsy; Female; Humans; Phenytoin; Valproic Acid

2014
Hemodialysis effects on phenytoin pharmacokinetics.
    European journal of clinical pharmacology, 2014, Volume: 70, Issue:4

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Kidney Failure, Chronic; Male; Phenytoin; Renal Dialysis

2014
Efficacy of dexamethasone on penicillin-induced epileptiform activity in rats: an electrophysiological study.
    Brain research, 2014, Mar-20, Volume: 1554

    Topics: Animals; Anticonvulsants; Brain; Dexamethasone; Disease Models, Animal; Dose-Response Relationship,

2014
Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs.
    Therapeutic drug monitoring, 2014, Volume: 36, Issue:4

    Topics: Acetamides; Adult; Aged; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Inte

2014
EMPACT syndrome: limited evidence despite a high-risk cohort.
    Journal of neuro-oncology, 2014, Volume: 119, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Neoplasms; Child; Cranial Irradia

2014
Laser light scan analysis of the "anticonvulsant face".
    Birth defects research. Part A, Clinical and molecular teratology, 2014, Volume: 100, Issue:12

    Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Case-Control Studies; Child; Cohort Studie

2014
4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy.
    Epilepsy research, 2014, Volume: 108, Issue:6

    Topics: Alleles; Amino-Acid N-Acetyltransferase; Ammonia; Anticonvulsants; Asian People; Biomarkers, Pharmac

2014
Adjuvant anticholinesterase therapy for the management of epilepsy-induced memory deficit: a critical pre-clinical study.
    Basic & clinical pharmacology & toxicology, 2014, Volume: 115, Issue:6

    Topics: Animals; Anticonvulsants; Atropine; Chemotherapy, Adjuvant; Cholinesterase Inhibitors; Epilepsy; Mal

2014
Reboxetine and its influence on the action of classical antiepileptic drugs in the mouse maximal electroshock model.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:3

    Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Drug Interactions; Electrosh

2014
Profound reduction in the tamoxifen active metabolite endoxifen in a patient on phenytoin for epilepsy compared with a CYP2D6 genotype matched cohort.
    Pharmacogenetics and genomics, 2014, Volume: 24, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Cohort Studies; Cytochrome P-450 CYP2D6; Drug Inte

2014
[Epilepsy in the child and in the adult. Part 1. Epilepsy in the child].
    La Revue du praticien, 2014, Volume: 64, Issue:5

    Topics: Anticonvulsants; Benzodiazepines; Child; Electroencephalography; Epilepsy; Follow-Up Studies; Humans

2014
A young woman with seizures and psychosis.
    BMJ case reports, 2014, Jul-09, Volume: 2014

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Hallucinations; Humans; Levetiracetam; Neuropsychological

2014
Angiopep-conjugated electro-responsive hydrogel nanoparticles: therapeutic potential for epilepsy.
    Angewandte Chemie (International ed. in English), 2014, Nov-10, Volume: 53, Issue:46

    Topics: Amygdala; Animals; Anticonvulsants; Blood-Brain Barrier; Cell Line; Drug Delivery Systems; Electrici

2014
Phenytoin-induced severe gingival overgrowth in a child.
    BMJ case reports, 2014, Jul-21, Volume: 2014

    Topics: Anticonvulsants; Child; Diagnosis, Differential; Epilepsy; Gingival Overgrowth; Humans; Male; Oral H

2014
Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models.
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:10

    Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri

2014
The P value: probable does not mean practical.
    Clinical chemistry, 2014, Volume: 60, Issue:7

    Topics: Anticonvulsants; Epilepsy; Humans; Phenytoin; Probability; Statistics, Nonparametric

2014
Erythematous-to-brownish plaques on the upper back: a quiz. Phenytoin-induced T-cell predominant pseudolymphoma (“pseudomycosis fungoides”) with T-cell clonality.
    Acta dermato-venereologica, 2015, Volume: 95, Issue:3

    Topics: Adult; Anticonvulsants; Biopsy; Drug Eruptions; Epilepsy; Erythema; Female; Humans; Immunophenotypin

2015
Individualized phenytoin therapy for Japanese pediatric patients with epilepsy based on CYP2C9 and CYP2C19 genotypes.
    Therapeutic drug monitoring, 2015, Volume: 37, Issue:2

    Topics: Adolescent; Alleles; Anticonvulsants; Asian People; Child; Child, Preschool; Cytochrome P-450 CYP2C1

2015
Effect of comedication on lamotrigine clearance in Korean epilepsy patients.
    Clinica chimica acta; international journal of clinical chemistry, 2015, Jan-01, Volume: 438

    Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Half-

2015
Clinical validation and implications of dried blood spot sampling of carbamazepine, valproic acid and phenytoin in patients with epilepsy.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Dried Blood Spot Testing; Drug Monitoring; Drug Therapy

2014
Switching between phenytoin generics in patients with epilepsy may lead to increased risk of breakthrough seizure: chart analysis and practice recommendations.
    International journal of clinical pharmacology and therapeutics, 2014, Volume: 52, Issue:12

    Topics: Adult; Aged; Anticonvulsants; Biological Availability; Drug Monitoring; Drug Substitution; Epilepsy;

2014
The effect of polymorphic metabolism enzymes on serum phenytoin level.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2015, Volume: 36, Issue:3

    Topics: Adult; Alleles; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Epilepsy; Female; Genotype; Human

2015
Chronic administration of phenytoin induces efflux transporter overexpression in rats.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:6

    Topics: Administration, Oral; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Membe

2014
Concurrence of myotonic dystrophy and epilepsy: a case report.
    Journal of medical case reports, 2014, Dec-15, Volume: 8

    Topics: Adult; Anticonvulsants; Electromyography; Epilepsy; Ethiopia; Humans; Male; Myotonic Dystrophy; Phen

2014
Cosmetic side effects of antiepileptic drugs in adults with epilepsy.
    Epilepsy & behavior : E&B, 2015, Volume: 42

    Topics: Acne Vulgaris; Adult; Alopecia; Anticonvulsants; Epilepsy; Female; gamma-Aminobutyric Acid; Gingival

2015
Effects of phenytoin and valproic acid on cognitive functions of Thai epileptic patients: a pilot study.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2014, Volume: 97 Suppl 2

    Topics: Adolescent; Adult; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Cognition; Ep

2014
[Follow-up of a cohort of patients after substitution of phenytoin for phenytoin sodium in an epilepsy center].
    Revue neurologique, 2015, Volume: 171, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Dosage Forms; Dose-Response Relationship, Drug; Dru

2015
Preliminary anticonvulsant and toxicity screening of substituted benzylidenehydrazinyl-N-(6-substituted benzo[d]thiazol-2-yl)propanamides.
    TheScientificWorldJournal, 2014, Volume: 2014

    Topics: Animals; Anticonvulsants; Benzothiazoles; Binding Sites; Dose-Response Relationship, Drug; Drug Eval

2014
Comparative behavioral and neurochemical analysis of phenytoin and valproate treatment on epilepsy induced learning and memory deficit: Search for add on therapy.
    Metabolic brain disease, 2015, Volume: 30, Issue:4

    Topics: Acetylcholinesterase; Animals; Anticonvulsants; Cerebral Cortex; Drug Therapy, Combination; Epilepsy

2015
Clinical relevance of genetic polymorphism in CYP2C9 gene to pharmacodynamics and pharmacokinetics of phenytoin in epileptic patients: validatory pharmacogenomic approach to pharmacovigilance.
    International journal of clinical pharmacology and therapeutics, 2015, Volume: 53, Issue:7

    Topics: Anticonvulsants; Area Under Curve; Biotransformation; Case-Control Studies; Cytochrome P-450 CYP2C9;

2015
Association analysis of CYP2C9*3 and phenytoin-induced severe cutaneous adverse reactions (SCARs) in Thai epilepsy children.
    Journal of human genetics, 2015, Volume: 60, Issue:8

    Topics: Anticonvulsants; Child; Child, Preschool; Cytochrome P-450 CYP2C9; Drug Eruptions; Epilepsy; Female;

2015
Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models.
    Naunyn-Schmiedeberg's archives of pharmacology, 2015, Volume: 388, Issue:10

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship,

2015
Paradoxical Seizure Response to Phenytoin in an Epileptic Heroin Addict.
    The neurologist, 2015, Volume: 19, Issue:6

    Topics: Adult; Anticonvulsants; Epilepsy; Heroin Dependence; Humans; Male; Phenytoin; Seizures

2015
CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy.
    The pharmacogenomics journal, 2016, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Case-Contro

2016
Potentially Unsafe Herb-drug Interactions Between a Commercial Product of Noni Juice and Phenytoin- A Case Report.
    Acta neurologica Taiwanica, 2015, Volume: 24, Issue:2

    Topics: Cytochrome P-450 CYP1A2 Inducers; Cytochrome P-450 CYP2C9 Inducers; Epilepsy; Fruit and Vegetable Ju

2015
Remarkable Phenytoin Sensitivity in 4 Children with SCN8A-related Epilepsy: A Molecular Neuropharmacological Approach.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2016, Volume: 13, Issue:1

    Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Mutation, Missense; NAV1.6

2016
Effect of carbamazepine or phenytoin therapy on blood level of intravenously administered midazolam: a prospective cohort study.
    Journal of anesthesia, 2016, Volume: 30, Issue:1

    Topics: Administration, Intravenous; Adult; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Therapy, Co

2016
Identifying Reverse Malingering in the Civilian Occupational Setting.
    Workplace health & safety, 2016, Volume: 64, Issue:7

    Topics: Adult; Anticonvulsants; Attitude to Health; Confidentiality; Disclosure; Epilepsy; Humans; Male; Mal

2016
Fluoxetine-induced phenytoin toxicity: a clinical reminder about the perils of polypharmacy.
    The New Zealand medical journal, 2015, Sep-25, Volume: 128, Issue:1422

    Topics: Antidepressive Agents, Second-Generation; Drug Interactions; Epilepsy; Female; Fluoxetine; Humans; M

2015
Effect observation of anti epileptic drugs on serum folic acid and vitamin B12 of epileptic patients.
    Minerva medica, 2015, Volume: 106, Issue:4

    Topics: Adult; Anticonvulsants; Biomarkers; Case-Control Studies; Drug Monitoring; Epilepsy; Female; Folic A

2015
Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy.
    Epilepsy research, 2015, Volume: 117

    Topics: Adolescent; Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Carbamazepine; Ch

2015
Concentration of antiepileptic drugs in persons with epilepsy: a comparative study in serum and saliva.
    The International journal of neuroscience, 2016, Volume: 126, Issue:11

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Middle Age

2016
Synaptic vesicle protein2A decreases in amygdaloid-kindling pharmcoresistant epileptic rats.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2015, Volume: 35, Issue:5

    Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Drug Resistance; Electric Stimulation; E

2015
Comparing paediatric intravenous phenytoin doses using physiologically based pharmacokinetic (PBPK) modelling software.
    Seizure, 2015, Volume: 33

    Topics: Administration, Intravenous; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, D

2015
Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats.
    Neuropharmacology, 2016, Volume: 106

    Topics: Animals; Anticonvulsants; Avoidance Learning; Benzothiazoles; Disease Models, Animal; Dose-Response

2016
Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy.
    Seizure, 2015, Volume: 33

    Topics: Adolescent; Ammonia; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Genotype; Glutamate

2015
What is This Rash?
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2016, Volume: 12, Issue:2

    Topics: Adrenal Cortex Hormones; Adult; Anticonvulsants; Drug Hypersensitivity Syndrome; Drug Substitution;

2016
Phenytoin neurotoxicity in a child carrying new STXBP1 and CYP2C9 gene mutations.
    Seizure, 2016, Volume: 34

    Topics: Anticonvulsants; Child; Child, Preschool; Cytochrome P-450 CYP2C9; Epilepsy; Humans; Infant; Infant,

2016
Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis.
    Seizure, 2016, Volume: 37

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fructose; Humans; Male; M

2016
The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy.
    Brain & development, 2016, Volume: 38, Issue:8

    Topics: Adolescent; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool; Clobazam; Clon

2016
Medication prescribing and patient-reported outcome measures in people with epilepsy in Bhutan.
    Epilepsy & behavior : E&B, 2016, Volume: 59

    Topics: Adult; Aged; Anticonvulsants; Bhutan; Carbamazepine; Drug Prescriptions; Electroencephalography; Epi

2016
Frequencies of CYP2C9 polymorphisms in North Indian population and their association with drug levels in children on phenytoin monotherapy.
    BMC pediatrics, 2016, 05-14, Volume: 16

    Topics: Anticonvulsants; Child; Child, Preschool; Cross-Sectional Studies; Cytochrome P-450 CYP2C9; Epilepsy

2016
Evaluating the Role of Genetic Variants on first-line antiepileptic drug response in North India: Significance of SCN1A and GABRA1 Gene Variants in Phenytoin Monotherapy and its Serum Drug Levels.
    CNS neuroscience & therapeutics, 2016, Volume: 22, Issue:9

    Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; India; Male; NAV1.1 Voltage-Gat

2016
Development, validation and clinical application of an online-SPE-LC-HRMS/MS for simultaneous quantification of phenobarbital, phenytoin, carbamazepine, and its active metabolite carbamazepine 10,11-epoxide.
    Talanta, 2016, Sep-01, Volume: 158

    Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Epilep

2016
Lacking the 'protective label' of diabetes: Phenytoin-induced distal symmetrical peripheral neuropathy. A clinical case report.
    Journal of tissue viability, 2016, Volume: 25, Issue:4

    Topics: Amputation, Surgical; Anticonvulsants; Epilepsy; Foot Ulcer; Gas Gangrene; Humans; Male; Middle Aged

2016
Epilepsy in Adults with Supratentorial Glioblastoma: Incidence and Influence Factors and Prophylaxis in 184 Patients.
    PloS one, 2016, Volume: 11, Issue:7

    Topics: Adult; Aged; Anticonvulsants; Craniotomy; Epilepsy; Female; Frontal Lobe; Glioblastoma; Humans; Male

2016
Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study.
    Medicine, 2016, Volume: 95, Issue:35

    Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilep

2016
Hyperhomocysteinaemia in children receiving phenytoin and carbamazepine monotherapy: a cross-sectional observational study.
    Archives of disease in childhood, 2017, Volume: 102, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Child, Preschool; Cross-Sectional Studi

2017
Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population-based case-control study.
    Brain and behavior, 2016, Volume: 6, Issue:11

    Topics: Adult; Aged; Anticonvulsants; Carcinoma, Hepatocellular; Case-Control Studies; Epilepsy; Humans; Liv

2016
Reversible lesion involving the splenium of the corpus callosum caused by phenytoin sodium withdrawal.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2017, Volume: 38, Issue:4

    Topics: Anticonvulsants; Brain Diseases; Corpus Callosum; Diagnosis, Differential; Epilepsy; Humans; Male; M

2017
Utility of Magnetic Resonance Imaging in the Surgical Management of Drug Extravasation: A Case Report.
    The journal of hand surgery Asian-Pacific volume, 2017, Volume: 22, Issue:1

    Topics: Adult; Anticonvulsants; Debridement; Epilepsy; Extravasation of Diagnostic and Therapeutic Materials

2017
Population Pharmacokinetics of Topiramate in Japanese Pediatric and Adult Patients With Epilepsy Using Routinely Monitored Data.
    Therapeutic drug monitoring, 2017, Volume: 39, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Asian People; Body Weight; Carbamazepine; Child; Child, Pr

2017
Prevalence of cardiovascular risk factors in people with epilepsy.
    Brain and behavior, 2017, Volume: 7, Issue:2

    Topics: Adult; Aged; Anticonvulsants; Cardiovascular Diseases; Comorbidity; Dyslipidemias; Epilepsy; Female;

2017
Phenytoin half-life and clearance during maintenance therapy in adults and elderly patients with epilepsy.
    Neurology, 2008, Jul-01, Volume: 71, Issue:1

    Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anticonvulsants; Drug Admi

2008
Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population.
    Epilepsia, 2008, Volume: 49, Issue:12

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Genetic Predisposition t

2008
Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins.
    Epilepsy research, 2008, Volume: 82, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Cysteine; Dipeptides; Drug Evaluation;

2008
Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery.
    Neurology, 2008, Aug-26, Volume: 71, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain; Brain Injuries; Drug Tolerance; Drug-Related

2008
Levetiracetam as a possible cause of fulminant liver failure.
    Neurology, 2008, Aug-26, Volume: 71, Issue:9

    Topics: Adult; Anticonvulsants; Brain; Epilepsy; Humans; Levetiracetam; Liver; Liver Failure, Acute; Liver F

2008
Agranulocytosis following phenytoin-induced hypersensitivity syndrome.
    Brain & development, 2009, Volume: 31, Issue:6

    Topics: Agranulocytosis; Anti-Bacterial Agents; Anticonvulsants; Cefepime; Cephalosporins; Chemical and Drug

2009
Severe postictal laryngospasm as a potential mechanism for sudden unexpected death in epilepsy: a near-miss in an EMU.
    Epilepsia, 2008, Volume: 49, Issue:12

    Topics: Adult; Anticonvulsants; Death, Sudden; Electroencephalography; Epilepsy; Humans; Laryngismus; Male;

2008
Treatment of epileptics with epanutin.
    The Journal of mental science, 1947, Volume: 93, Issue:393

    Topics: Epilepsy; Humans; Phenytoin

1947
Effect of phenytoin and valproic acid therapy on serum lipid levels and liver function tests.
    Indian pediatrics, 2008, Volume: 45, Issue:10

    Topics: Anticonvulsants; Case-Control Studies; Child; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Epile

2008
Phenytoin toxicity due to genetic polymorphism.
    Neurocritical care, 2009, Volume: 10, Issue:2

    Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Brain Injuries; Cytochrome P-450 CYP2C9; Epilepsy; F

2009
Dose adjustment of phenytoin for comedication in Japanese patients with epilepsy.
    Therapeutic drug monitoring, 2009, Volume: 31, Issue:1

    Topics: Adult; Aged; Aging; Algorithms; Anticonvulsants; Body Surface Area; Body Water; Body Weight; Drug In

2009
Synthesis and anticonvulsant activity of 5-chloro-2(3H)-benzoxazolinone-3-acetyl-2-(o/p-substituted benzal) hydrazone derivatives.
    Arzneimittel-Forschung, 2008, Volume: 58, Issue:11

    Topics: Animals; Anticonvulsants; Convulsants; Epilepsy; Hydrazones; Magnetic Resonance Spectroscopy; Male;

2008
Drug treatment of epilepsy in the century of the ILAE: the first 50 years, 1909-1958.
    Epilepsia, 2009, Volume: 50 Suppl 3

    Topics: Advertising; Anticonvulsants; Bromides; Epilepsy; Herbal Medicine; History, 18th Century; History, 1

2009
Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.
    The New England journal of medicine, 2009, Apr-16, Volume: 360, Issue:16

    Topics: Adult; Anticonvulsants; Carbamazepine; Child, Preschool; Cognition; Developmental Disabilities; Dose

2009
Anticonvulsant effect of Ficus religiosa: role of serotonergic pathways.
    Journal of ethnopharmacology, 2009, Jun-22, Volume: 123, Issue:2

    Topics: Animals; Anticonvulsants; Cyproheptadine; Diazepam; Disease Models, Animal; Dose-Response Relationsh

2009
Intestinal obstruction and phenytoin intoxication.
    Pediatrics international : official journal of the Japan Pediatric Society, 2009, Volume: 51, Issue:3

    Topics: Anticonvulsants; Comorbidity; Epilepsy; Female; Half-Life; Humans; Intestinal Absorption; Intestinal

2009
Bone disease induced by phenytoin therapy: clinical and experimental study.
    European neurology, 2009, Volume: 62, Issue:4

    Topics: Adult; Aged; Animals; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Epilepsy; Female; Femu

2009
Guidelines for diagnosis and management of childhood epilepsy.
    Indian pediatrics, 2009, Volume: 46, Issue:8

    Topics: Algorithms; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Hu

2009
Differences between the measured and calculated free serum phenytoin concentrations in epileptic patients.
    Yonsei medical journal, 2009, Aug-31, Volume: 50, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle

2009
COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats.
    Neuropharmacology, 2010, Volume: 58, Issue:2

    Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri

2010
The little compound that could: how phenytoin changed drug discovery and development.
    Molecular interventions, 2009, Volume: 9, Issue:5

    Topics: Anticonvulsants; Drug Discovery; Epilepsy; History, 20th Century; Humans; Phenytoin; United States

2009
Phenytoin toxicity and thyroid dysfunction.
    The New Zealand medical journal, 2009, Sep-25, Volume: 122, Issue:1303

    Topics: Anticonvulsants; Epilepsy; Female; Follow-Up Studies; Humans; Hypothyroidism; Middle Aged; Phenytoin

2009
CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:2

    Topics: Anticoagulants; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Base Sequence; Cytochrome P-450 CYP2

2010
Utility of levetiracetam in patients with subarachnoid hemorrhage.
    Seizure, 2009, Volume: 18, Issue:10

    Topics: Adult; Aged; Anticonvulsants; Epilepsy; Female; Follow-Up Studies; Humans; Levetiracetam; Male; Midd

2009
Effect of pharmacist participation in the health care team on therapeutic drug monitoring utilization for antiepileptic drugs.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2009, Volume: 92, Issue:11

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Chi-Square Distribution;

2009
Valproic acid: long-term effects on children exposed in utero.
    Prescrire international, 2009, Volume: 18, Issue:104

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Contraindications; Dose

2009
Adverse effects of carbamazepine, phenytoin, valproate and lamotrigine monotherapy in epileptic adult Chinese patients.
    Clinical neurology and neurosurgery, 2010, Volume: 112, Issue:4

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; China; Drug Eruptions; Epilepsy; Female; Hu

2010
Sporadic hemiplegic migraine and epilepsy associated with CACNA1A gene mutation.
    Epilepsy & behavior : E&B, 2010, Volume: 17, Issue:2

    Topics: Adult; Anticonvulsants; Calcium Channels; Chromosomes, Human, Pair 19; Epilepsy; Female; Humans; Inj

2010
Anticonvulsant activity of DNS II fraction in the acute seizure models.
    Journal of ethnopharmacology, 2010, Apr-21, Volume: 128, Issue:3

    Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbre

2010
Reduced phenytoin levels in an epileptic patient following Roux-En-Y gastric bypass for obesity.
    Obesity surgery, 2011, Volume: 21, Issue:5

    Topics: Anticonvulsants; Body Mass Index; Epilepsy; Gastric Bypass; Humans; Lamotrigine; Male; Middle Aged;

2011
Dilantin in the treatment of epilepsy.
    The Nebraska state medical journal, 1947, Volume: 32, Issue:7

    Topics: Epilepsy; Humans; Phenytoin

1947
Isopropyl alcohol, other ketogens, and miscellaneous agents on thresholds for electrical convulsions and diphenylhydantoin.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1947, Volume: 64, Issue:2

    Topics: 2-Propanol; Epilepsy; Humans; Ketone Bodies; Phenytoin; Seizures; Therapeutics

1947
Dilantin treatment for behavior problem children with abnormal electroencephalograms.
    The American journal of psychiatry, 1947, Volume: 103, Issue:4

    Topics: Brain; Child; Electroencephalography; Epilepsy; Humans; Mental Disorders; Phenytoin

1947
Tridione-diphenylhydantoin combination therapy in grand mal with slow-wave EEG dysrhythmia.
    Federation proceedings, 1947, Volume: 6, Issue:1

    Topics: Combined Modality Therapy; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenyto

1947
Determination of free and total levels of phenytoin in human plasma from patients with epilepsy by MEKC: an adequate alternative to HPLC.
    Electrophoresis, 2010, Volume: 31, Issue:9

    Topics: Adult; Calibration; Chromatography, High Pressure Liquid; Chromatography, Micellar Electrokinetic Ca

2010
Intracerebral hemorrhage and seizures.
    Journal of neurosurgery, 2010, Volume: 112, Issue:4

    Topics: Anticonvulsants; Cerebral Hemorrhage; Epilepsy; Humans; Phenytoin; Prevalence

2010
Comparative effectiveness of 10 antiepileptic drugs in older adults with epilepsy.
    Archives of neurology, 2010, Volume: 67, Issue:4

    Topics: Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dose-Response Rela

2010
Influence of CYP2C9 and CYP2C19 genetic polymorphisms on phenytoin-induced neurological toxicity in Indian epileptic patients.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:7

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Epilepsy; F

2010
Absence of a general association between ABCB1 genetic variants and response to antiepileptic drugs in epilepsy patients.
    Biochimie, 2010, Volume: 92, Issue:9

    Topics: Adolescent; Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Casse

2010
Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.
    Pharmacogenomics, 2010, Volume: 11, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Case-Control Studi

2010
Phenytoin induced vitamin D deficiency presenting as proximal muscle weakness.
    Indian pediatrics, 2010, Volume: 47, Issue:7

    Topics: Child; Epilepsy; Female; Gait; Humans; Hyperparathyroidism, Secondary; Muscle Weakness; Phenytoin; V

2010
Age and comedications influence levetiracetam pharmacokinetics in children.
    Pediatric neurology, 2010, Volume: 43, Issue:4

    Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions;

2010
Treatment of epilepsy in children with sodium dilantin.
    Journal of the Medical Association of Georgia, 1946, Volume: 35

    Topics: Child; Epilepsy; Humans; Phenytoin; Sodium

1946
Influence of CYP2C9 genetic polymorphism and undernourishment on plasma-free phenytoin concentrations in epileptic patients.
    Therapeutic drug monitoring, 2010, Volume: 32, Issue:6

    Topics: Adult; Alleles; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Epilepsy; F

2010
An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges.
    Brain research, 2011, Jan-31, Volume: 1371

    Topics: Action Potentials; Animals; Anticonvulsants; Cell Survival; Epilepsy; Ethosuximide; Glutamic Acid; H

2011
A sensitive and selective HPLC method for estimation of lamotrigine in human plasma and saliva: application to plasma-saliva correlation in epileptic patients.
    Arzneimittel-Forschung, 2010, Volume: 60, Issue:10

    Topics: Anticonvulsants; Calibration; Chromatography, High Pressure Liquid; Epilepsy; Humans; Indicators and

2010
Excretion of the principal urinary metabolites of phenytoin and absolute oral bioavailability determined by use of a stable isotope in patients with epilepsy.
    Therapeutic drug monitoring, 2011, Volume: 33, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Biological Availability; Chromatography, High Press

2011
Suicidal risk and suicide attempts in people treated with antiepileptic drugs for epilepsy.
    Seizure, 2011, Volume: 20, Issue:4

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Comorbidity; Depressive Disorder; Electroencephalography;

2011
A candidate gene study of antiepileptic drug tolerability and efficacy identifies an association of CYP2C9 variants with phenytoin toxicity.
    European journal of neurology, 2011, Volume: 18, Issue:9

    Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Epilepsy; Female; Genetic A

2011
[Resistance to vecuronium induced muscle relaxation in a patient with mental retardation receiving phenytoin for chronic anticonvulsant therapy].
    Masui. The Japanese journal of anesthesiology, 2011, Volume: 60, Issue:1

    Topics: Adult; Anesthesia, General; Drug Interactions; Drug Resistance; Epilepsy; Female; Humans; Intellectu

2011
SCN1A splice variants exhibit divergent sensitivity to commonly used antiepileptic drugs.
    Epilepsia, 2011, Volume: 52, Issue:5

    Topics: Alternative Splicing; Anticonvulsants; Epilepsy; Humans; Lamotrigine; NAV1.1 Voltage-Gated Sodium Ch

2011
Early postnatal exposure of rats to lamotrigine, but not phenytoin, reduces seizure threshold in adulthood.
    Epilepsia, 2011, Volume: 52, Issue:4

    Topics: Aging; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Female; Lamotrigine; Male; Phenyt

2011
[Ophthalmoplegia produced by phenytoin].
    Neurologia (Barcelona, Spain), 2009, Volume: 24, Issue:9

    Topics: Anticonvulsants; Epilepsy; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Ophthalmoplegia; P

2009
Prophylactic anticonvulsants after subarachnoid hemorrhage.
    World neurosurgery, 2011, Volume: 75, Issue:2

    Topics: Anticonvulsants; Epilepsy; Humans; Incidence; Levetiracetam; Phenytoin; Piracetam; Subarachnoid Hemo

2011
Comparison of short-duration levetiracetam with extended-course phenytoin for seizure prophylaxis after subarachnoid hemorrhage.
    World neurosurgery, 2011, Volume: 75, Issue:2

    Topics: Adult; Aged; Anticonvulsants; Databases, Factual; Delayed-Action Preparations; Disease-Free Survival

2011
Association of antiepileptic drugs, vitamin D, and calcium supplementation with bone fracture occurrence in epilepsy patients.
    Clinical neurology and neurosurgery, 2011, Volume: 113, Issue:7

    Topics: Age Factors; Anticonvulsants; Calcium; Cohort Studies; Dietary Supplements; Epilepsy; Female; Fractu

2011
[Development of rapid genotyping methods for single nucleotide polymorphisms of cytochrome P450 2C9 (CYP2C9) and cytochrome P450 2C19 (CYP2C19) and their clinical application in pediatric patients with epilepsy].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2011, Volume: 131, Issue:5

    Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Child, Preschool; Cytochrome P-450 CYP2C19; Cytochro

2011
Pharmacogenetics: reality or fiction? Or are we there yet?
    Arquivos de neuro-psiquiatria, 2011, Volume: 69, Issue:2A

    Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Epilepsy; Female; Humans; M

2011
CYP2C9 polymorphism in patients with epilepsy: genotypic frequency analyzes and phenytoin adverse reactions correlation.
    Arquivos de neuro-psiquiatria, 2011, Volume: 69, Issue:2A

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Ep

2011
[A case of toxicity caused by drug interaction between capecitabine and phenytoin in patient with colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:5

    Topics: Adult; Anticonvulsants; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycy

2011
Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 99, Issue:3

    Topics: Animals; Anticonvulsants; Carbamazepine; Curcumin; Disease Models, Animal; Drug Interactions; Drug T

2011
Clinical and pharmacy utilization outcomes with brand to generic antiepileptic switches in patients with epilepsy.
    Epilepsia, 2011, Volume: 52, Issue:7

    Topics: Anticonvulsants; Drug Substitution; Drugs, Generic; Emergency Service, Hospital; Epilepsy; Female; H

2011
Normal vitamin D and low free estradiol levels in women on enzyme-inducing antiepileptic drugs.
    Epilepsy & behavior : E&B, 2011, Volume: 21, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Bone Density; Carbamazepine; Epilepsy; Estradiol; Female; Humans

2011
Vinpocetine inhibits glutamate release induced by the convulsive agent 4-aminopyridine more potently than several antiepileptic drugs.
    Epilepsy research, 2011, Volume: 96, Issue:3

    Topics: 4-Aminopyridine; Animals; Anticonvulsants; Calcium; Carbamazepine; Drug Interactions; Epilepsy; Fruc

2011
Capecitabine-phenytoin interaction is dose dependent with an unexpected time course.
    Anti-cancer drugs, 2011, Volume: 22, Issue:10

    Topics: Aged; Anticonvulsants; Antineoplastic Agents; Breast Neoplasms; Capecitabine; Deoxycytidine; Dose-Re

2011
[Epilepsy in elderly].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:7

    Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies,

2011
Phenytoin intoxication induced by Mandrax (methaqualone).
    Epilepsy research, 2012, Volume: 98, Issue:2-3

    Topics: Anticonvulsants; Cerebellar Diseases; Diphenhydramine; Drug Combinations; Epilepsy; Humans; Male; Me

2012
Correlation between serum and salivary phenytoin concentrations in Thai epileptic children.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2011, Volume: 94 Suppl 3

    Topics: Anticonvulsants; Asian People; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy;

2011
Effects of long-term antiepileptic drug monotherapy on vascular risk factors and atherosclerosis.
    Epilepsia, 2012, Volume: 53, Issue:1

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Atherosclerosis; Blood Glucose; Carbamazepine; Carotid Art

2012
Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro.
    Neurobiology of disease, 2012, Volume: 45, Issue:2

    Topics: Action Potentials; Animals; Anticonvulsants; Brain Injuries; Cell Death; Epilepsy; Excitatory Amino

2012
Conversion from enzyme-inducing antiepileptic drugs to topiramate: effects on lipids and C-reactive protein.
    Epilepsy research, 2012, Volume: 98, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; C-Reactive Protein; Carbamazepine; Epilepsy; Female

2012
Genetic polymorphism of NAT2 metabolizing enzymes on phenytoin pharmacokinetics in Indian epileptic patients developing toxicity.
    CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Arylamine N-Acetyltransferase; Epilepsy; Female; Gene Frequency; Humans; India; M

2012
Clinical decision support of therapeutic drug monitoring of phenytoin: measured versus adjusted phenytoin plasma concentrations.
    BMC medical informatics and decision making, 2012, Feb-14, Volume: 12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Chi-Square Distribution; Child; Child,

2012
Thyroid hormones may contribute to vascular risk factors and atherosclerosis.
    Epilepsia, 2012, Volume: 53, Issue:4

    Topics: Anticonvulsants; Atherosclerosis; Carbamazepine; Carotid Artery, Common; Epilepsy; Female; Humans; M

2012
Characterization of glucose homeostasis and lipid profile in adult, seizure-free, epileptic patients in Asian population.
    European journal of neurology, 2012, Volume: 19, Issue:9

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Asian People; Blood Glucose; Cholesterol, LDL; Cross-Secti

2012
Assessing adherence-based quality measures in epilepsy.
    International journal for quality in health care : journal of the International Society for Quality in Health Care, 2012, Volume: 24, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cohort Studies; Epilepsy; Female; Follow-Up

2012
Seizure management at Auckland City Hospital Emergency Department between July and December 2009: time for a change?
    Internal medicine journal, 2012, Volume: 42, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Disease Management; Emer

2012
The effect of combination therapy on the plasma concentrations of traditional antiepileptics: a retrospective study.
    Human & experimental toxicology, 2012, Volume: 31, Issue:10

    Topics: Adolescent; Adult; Age Factors; Aged; Analysis of Variance; Anticonvulsants; Carbamazepine; Drug Int

2012
A rat model for LGI1-related epilepsies.
    Human molecular genetics, 2012, Aug-15, Volume: 21, Issue:16

    Topics: Amino Acid Sequence; Animals; Anticonvulsants; Brain; Carbamazepine; Cells, Cultured; Chlorocebus ae

2012
Functional genetic polymorphisms from phase-II drug metabolizing enzymes.
    CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:8

    Topics: Arylamine N-Acetyltransferase; Epilepsy; Female; Humans; Male; Phenytoin; Polymorphism, Genetic

2012
Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms.
    The pharmacogenomics journal, 2013, Volume: 13, Issue:4

    Topics: Alleles; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding C

2013
B-vitamin deficiency in patients treated with antiepileptic drugs.
    Epilepsy & behavior : E&B, 2012, Volume: 24, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans

2012
Concentrations of stiripentol in children and adults with epilepsy: the influence of dose, age, and comedication.
    Therapeutic drug monitoring, 2012, Volume: 34, Issue:4

    Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Child; Child, Preschool; Dioxolanes; Dose-Response

2012
Generalised stunting of roots in an epileptic child: is long-term phenytoin therapy the cause?
    BMJ case reports, 2012, Jul-03, Volume: 2012

    Topics: Adolescent; Anticonvulsants; Calcinosis; Diagnosis, Differential; Epilepsy; Female; Follow-Up Studie

2012
DRESS syndrome.
    BMJ case reports, 2012, Jul-03, Volume: 2012

    Topics: Administration, Oral; Adolescent; Anticonvulsants; Diagnosis, Differential; Drug Hypersensitivity Sy

2012
Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore.
    Neurology, 2012, Sep-18, Volume: 79, Issue:12

    Topics: Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Cost-Benefit Analysis; Decision Making

2012
Effects of polymorphisms in six candidate genes on phenytoin maintenance therapy in Han Chinese patients.
    Pharmacogenomics, 2012, Volume: 13, Issue:12

    Topics: Adult; Alleles; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; ATP Binding Cassette T

2012
A novel microextraction by packed sorbent-gas chromatography procedure for the simultaneous analysis of antiepileptic drugs in human plasma and urine.
    Journal of separation science, 2012, Volume: 35, Issue:21

    Topics: Alprazolam; Anticonvulsants; Carbamazepine; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans;

2012
Asymmetric dimethylarginine may contribute to vascular risk factors in patients receiving antiepileptic drug treatment.
    Epilepsia, 2012, Volume: 53, Issue:10

    Topics: Anticonvulsants; Atherosclerosis; Carbamazepine; Carotid Artery, Common; Epilepsy; Female; Humans; M

2012
Comparative stroke risk of antiepileptic drugs in patients with epilepsy.
    Epilepsia, 2013, Volume: 54, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male

2013
Overexpression of multidrug resistance-associated protein 2 in the brain of pentylenetetrazole-kindled rats.
    Neuroscience, 2012, Dec-27, Volume: 227

    Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Chromatography, Liquid; Coloring Agents; Conv

2012
Role of CYP2C9 polymorphism in phenytoin-related metabolic abnormalities and subclinical atherosclerosis in young adult epileptic patients.
    Seizure, 2013, Volume: 22, Issue:2

    Topics: Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Atherosclerosis; Cross-Sectional Studies; Cyt

2013
How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)?
    Epilepsia, 2012, Volume: 53 Suppl 8

    Topics: Anticonvulsants; Carbamazepine; Drug Discovery; Epilepsy; Ethosuximide; History, 20th Century; Human

2012
Association of apolipoprotein E ε4 allele with cognitive impairment in patients with epilepsy and interaction with phenytoin monotherapy.
    Epilepsy & behavior : E&B, 2013, Volume: 26, Issue:2

    Topics: Adult; Anticonvulsants; Apolipoprotein E4; Case-Control Studies; Cholesterol; Cognition Disorders; E

2013
The association between BsmI polymorphism and bone mineral density in young patients with epilepsy who are taking phenytoin.
    Epilepsia, 2013, Volume: 54, Issue:2

    Topics: 25-Hydroxyvitamin D 2; Absorptiometry, Photon; Adolescent; Adult; Anticonvulsants; Bone Density; Cal

2013
The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy.
    Seizure, 2013, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Aged; Alleles; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Atrophy; Cerebella

2013
Effect of prenatal exposure to anticonvulsant drugs on dermal ridge patterns of fingers.
    Teratology, 2002, Volume: 66, Issue:1

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Dermatogly

2002
Relationship between changes in drug score, D-glucaric acid excretion, and gamma-glutamyltransferase and beta-glucuronidase serum activities during anticonvulsant treatment.
    Clinical laboratory, 2002, Volume: 48, Issue:7-8

    Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Enzyme Induction; Epilepsy;

2002
Chondrodysplasia punctata (CDP) with features of the tibia-metacarpal type and maternal phenytoin treatment during pregnancy.
    Prenatal diagnosis, 2002, Volume: 22, Issue:8

    Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Chondrodysplasia Punctata; Craniofacial Abnormalit

2002
Adverse effects of phenytoin given for late-onset seizures in adults with Down syndrome.
    Neurology, 2002, Sep-10, Volume: 59, Issue:5

    Topics: Adult; Age of Onset; Aged; Anticonvulsants; Down Syndrome; Epilepsy; Female; Humans; Male; Middle Ag

2002
Phenytoin toxicity as a result of 5-fluorouracil administration.
    The New Zealand medical journal, 2002, Aug-09, Volume: 115, Issue:1159

    Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Drug Interactions; Epilepsy; Female; Fluorouracil;

2002
Neurotoxic damage of granule cells in the dentate gyrus and the cerebellum and cognitive deficit following neonatal administration of phenytoin in mice.
    Journal of neuropathology and experimental neurology, 2002, Volume: 61, Issue:11

    Topics: Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Body Weight; Cerebellum; Cognition Disorders;

2002
Incidence of phenytoin induced gingival overgrowth in epileptic children: a six month evaluation.
    Journal of the Indian Society of Pedodontics and Preventive Dentistry, 2002, Volume: 20, Issue:2

    Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Gingival Hyperplasia; Humans; Incidence; Phenytoin

2002
Administration of phenytoin and cytomegalovirus infection in the terminal ileum.
    Journal of gastroenterology and hepatology, 2002, Volume: 17, Issue:11

    Topics: Aged; Anticonvulsants; Cytomegalovirus Infections; Diagnosis, Differential; Epilepsy; Female; Humans

2002
Reversible panhypogammaglobulinemia associated with phenytoin treatment.
    Scandinavian journal of infectious diseases, 2002, Volume: 34, Issue:10

    Topics: Adult; Agammaglobulinemia; Anticonvulsants; Epilepsy; Female; Follow-Up Studies; Headache; Humans; I

2002
Truncus arteriosus in fetal hydantoin syndrome - a new association?
    Indian pediatrics, 2003, Volume: 40, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Epilepsy; Fatal Outcom

2003
Variability of total phenytoin serum concentrations within elderly nursing home residents.
    Neurology, 2003, Feb-25, Volume: 60, Issue:4

    Topics: Age Distribution; Aged; Aged, 80 and over; Body Weight; Dosage Forms; Drug Administration Routes; Ep

2003
Evaluation of therapeutic drug monitoring of antiepileptic drugs.
    International journal of clinical pharmacology and therapeutics, 2003, Volume: 41, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Rela

2003
Serum phenytoin concentration and IgG antibody titre to periodontal bacteria in patients with phenytoin-induced gingival overgrowth.
    Journal of the International Academy of Periodontology, 2001, Volume: 3, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aggregatibacter actinomycetemcomitans; Antibodies, Ba

2001
[Epileptic Münchausen syndrome by idiosyncratic of effect antiepileptic drugs].
    Revue neurologique, 2003, Volume: 159, Issue:3

    Topics: Adult; Anticonvulsants; Diazepam; Electroencephalography; Epilepsy; Female; Headache; Humans; Muncha

2003
Phenytoin-diazepam interaction.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:5

    Topics: Adult; Anticonvulsants; Diazepam; Drug Interactions; Epilepsy; Humans; Male; Phenytoin

2003
Cerebellar volume and long-term use of phenytoin.
    Seizure, 2003, Volume: 12, Issue:5

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Cerebellum; Child; Child, Preschool; Dose-Response Relatio

2003
Adverse events associated with intravenous phenytoin in children: a prospective study.
    Seizure, 2003, Volume: 12, Issue:6

    Topics: Adolescent; Anticonvulsants; Arrhythmia, Sinus; Child; Child, Preschool; Epilepsy; Extravasation of

2003
Use of biperiden hydrochloride in a child with severe dyskinesia induced by phenytoin.
    Journal of child neurology, 2003, Volume: 18, Issue:7

    Topics: Anticonvulsants; Biperiden; Child, Preschool; Dyskinesia, Drug-Induced; Electroencephalography; Epil

2003
Vigabatrin-induced decrease in serum phenytoin concentration does not involve a change in phenytoin bioavailability.
    British journal of clinical pharmacology, 1993, Volume: 36, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Biological Availability; Drug Combinations; Drug Interactions; E

1993
[Experiences with comital and comital-L].
    Medizinische Monatsschrift, 1951, Volume: 5, Issue:12

    Topics: Barbiturates; Drug Combinations; Epilepsy; Hydantoins; Mephobarbital; Phenobarbital; Phenytoin

1951
Nuvarone (3-methyl-5, phenylhydantoin) in the treatment of epilepsy.
    Diseases of the nervous system, 1953, Volume: 14, Issue:4

    Topics: Epilepsy; Hydantoins; Phenytoin

1953
Diphenylhydantoin, adrenal function and epilepsy.
    The Journal of endocrinology, 1953, Volume: 9, Issue:2

    Topics: Adrenal Cortex; Epilepsy; Hydantoins; Phenytoin

1953
[Clinical experiences with diphenylhydantoins in the treatment of epilepsy, with special reference to lepitoin].
    Das Deutsche Gesundheitswesen, 1953, Mar-26, Volume: 8, Issue:13

    Topics: Epilepsy; Hydantoins; Phenytoin

1953
[Significance of the attack point of diphenylhydantoin, phenobarbital and the acylureas for our comprehension of the physiopathological mechanism of epilepsy].
    Helvetica physiologica et pharmacologica acta, 1953, Volume: 11, Issue:2

    Topics: Animals; Barbiturates; Behavior, Animal; Comprehension; Epilepsy; Humans; Hydantoins; Phenobarbital;

1953
[Effects of phenobarbital, acylureas and diphenylhydantoin on coma during electric epileptic crisis in guinea pig. II..].
    Helvetica physiologica et pharmacologica acta, 1953, Volume: 11, Issue:3

    Topics: Anticonvulsants; Barbiturates; Coma; Electricity; Epilepsy; Guinea Pigs; Phenobarbital; Phenytoin; S

1953
[Further study on paradental changes caused by diphenylhydantoin sodium].
    Rivista italiana di stomatologia, 1953, Volume: 8, Issue:11

    Topics: Disease; Epilepsy; Hydantoins; Hyperplasia; Hypertrophy; Periodontal Diseases; Periodontium; Phenyto

1953
Megaloblastic anaemia due to phenytoin sodium.
    Lancet (London, England), 1954, Oct-09, Volume: 267, Issue:6841

    Topics: Anemia; Anemia, Megaloblastic; Epilepsy; Humans; Hydantoins; Phenytoin

1954
Megaloblastic anaemia due to phenytoin sodium.
    Lancet (London, England), 1954, Oct-30, Volume: 267, Issue:6844

    Topics: Anemia; Anemia, Megaloblastic; Epilepsy; Humans; Hydantoins; Phenytoin

1954
[Adrenocortical function, diphenylhydantoin and epilepsy].
    Orvosi hetilap, 1954, Dec-05, Volume: 95, Issue:49

    Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Epilepsy; Humans; Hydantoins; Phenytoin

1954
Hypertrichosis occurring in association with dilantin therapy.
    The Journal of pediatrics, 1955, Volume: 47, Issue:3

    Topics: Child; Epilepsy; Hair; Hair Diseases; Humans; Hydantoins; Hypertrichosis; Infant; Phenytoin

1955
Speculations regarding the nature of gingival hyperplasia due to diphenylhydantoin-sodium.
    Acta medica Scandinavica, 1956, Jan-31, Volume: 153, Issue:5

    Topics: Disease; Epilepsy; Gingiva; Gingival Diseases; Gingival Hyperplasia; Hydantoins; Hyperplasia; Hypert

1956
Treatment of epilepsy with diphenylhydantoin sodium (dilantin sodium).
    Postgraduate medicine, 1956, Volume: 20, Issue:6

    Topics: Epilepsy; Humans; Hydantoins; Phenytoin; Sodium

1956
Treatment of epilepsy with diphenylhydantoin sodium (dilantin sodium).
    Postgraduate medicine, 1956, Volume: 20, Issue:6

    Topics: Epilepsy; Humans; Hydantoins; Phenytoin; Sodium

1956
Treatment of epilepsy with diphenylhydantoin sodium (dilantin sodium).
    Postgraduate medicine, 1956, Volume: 20, Issue:6

    Topics: Epilepsy; Humans; Hydantoins; Phenytoin; Sodium

1956
Treatment of epilepsy with diphenylhydantoin sodium (dilantin sodium).
    Postgraduate medicine, 1956, Volume: 20, Issue:6

    Topics: Epilepsy; Humans; Hydantoins; Phenytoin; Sodium

1956
Megaloblastic anaemia occurring during treatment of epilepsy with phenytoin sodium, primidone and phenobarbitone.
    The Journal of mental science, 1957, Volume: 103, Issue:432

    Topics: Anemia; Anemia, Megaloblastic; Anticonvulsants; Epilepsy; Humans; Hydantoins; Phenobarbital; Phenyto

1957
Use of parenteral diphenylhydantoin (dilantin) sodium in control of status epilepticus.
    A.M.A. archives of neurology and psychiatry, 1958, Volume: 79, Issue:2

    Topics: Epilepsy; Hydantoins; Ions; Phenytoin; Sodium; Sodium, Dietary; Status Epilepticus

1958
Diphenylhydantoin and phenobarbital in serum in patients with epilepsy.
    Danish medical bulletin, 1958, Volume: 5, Issue:5

    Topics: Epilepsy; Humans; Hydantoins; Phenobarbital; Phenytoin

1958
[Dilantin therapy of epilepsy in children].
    Suvremenna meditsina, 1957, Volume: 8, Issue:11

    Topics: Child; Epilepsy; Humans; Hydantoins; Infant; Phenytoin

1957
Dilantin toxicity. A clinical and electroence-phalographic study.
    Neurology, 1961, Volume: 11

    Topics: Epilepsy; Hydantoins; Phenytoin

1961
[Status of epilepsy in children: clinical experience with sodium diphenylhydantoin by parenteral route].
    Arquivos de neuro-psiquiatria, 1961, Volume: 19

    Topics: Child; Epilepsy; Hydantoins; Infant; Phenytoin; Sodium

1961
[Experimentation with a new antiepileptic drug derived from phenytoin: 5,5-diphenyltetrahydroimidazole-4-one (glior)].
    Therapie, 1959, Volume: 14

    Topics: Anticonvulsants; Epilepsy; Imidazoles; Phenytoin; Research Design

1959
Aspects of the pharmacology of phenytoin (dilantin) and phenobarbital relevant to their dosage in the treatment of epilepsy.
    Epilepsia, 1960, Volume: 1

    Topics: Epilepsy; Humans; Hydantoins; Phenobarbital; Phenytoin

1960
[Use of parenteral dilantin sodium in control of neurosurgical convulsive seizure].
    No to shinkei = Brain and nerve, 1962, Volume: 14

    Topics: Epilepsy; Hydantoins; Neurosurgery; Neurosurgical Procedures; Phenytoin; Seizures; Sodium

1962
Differential effects of antiepileptics on hippocampal and pallidal afterdischarges in cats.
    Japanese journal of pharmacology, 1962, Volume: 12

    Topics: Animals; Anticonvulsants; Cats; Epilepsy; Globus Pallidus; Hippocampus; Phenobarbital; Phenytoin

1962
[Now and then: development of drug treatment of epilepsy since A. Hauptmann].
    Munchener medizinische Wochenschrift (1950), 1962, Nov-02, Volume: 104

    Topics: Anticonvulsants; Epilepsy; Humans; Phenobarbital; Phenytoin; Primidone; Pyrrolidinones

1962
Treatment of epilepsy.
    Canadian Medical Association journal, 1963, Jun-29, Volume: 88

    Topics: Acetazolamide; Anticonvulsants; Automatism; Child; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clon

1963
A fatal case of erythema multiforme exudativum (Stevens-Johnson's syndrome) following therapy with dilantin.
    Pediatrics, 1962, Volume: 30

    Topics: Drug Eruptions; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenytoin; Seizures; Stevens-Johnson Syndr

1962
Fatal liver necrosis and diphenylhydantoin sensitivity.
    Pediatrics, 1962, Volume: 30

    Topics: Drug Hypersensitivity; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Liver Diseases; Phenytoin; Seizures

1962
ANTIEPILEPTIC DRUGS.
    The American journal of nursing, 1963, Volume: 63

    Topics: Acetazolamide; Amphetamine; Amphetamines; Anticonvulsants; Barbiturates; Bromides; Epilepsy; Ethosux

1963
ANTI-EPILEPTIC DRUGS AND THE FOETUS.
    British medical journal, 1963, Nov-16, Volume: 2, Issue:5367

    Topics: Barbiturates; Epilepsy; Female; Fetal Diseases; Fetus; Phenobarbital; Phenytoin; Pregnancy; Pregnanc

1963
MEGALOBLASTIC ANAEMIA ASSOCIATED WITH ANTICONVULSANT THERAPY.
    The Practitioner, 1963, Volume: 191

    Topics: Amobarbital; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Barbiturates; Epilepsy; Fol

1963
BEHAVIOR DISORDERS OF INTEREST TO DERMATOLOGISTS.
    Archives of dermatology, 1963, Volume: 88

    Topics: Adolescent; Behavior; Bites and Stings; Child; Child Behavior Disorders; Dermatology; Epilepsy; Fing

1963
THORAZINE AS AN EPILEPTOGENIC AGENT.
    The American journal of psychiatry, 1963, Volume: 120

    Topics: Chlorpromazine; Epilepsy; Humans; Pharmacology; Phenytoin; Primidone; Schizophrenia

1963
[A CURED CASE OF PANMYELOPATHY DUE TO HYDANTOIN THERAPY].
    Orvosi hetilap, 1963, Sep-22, Volume: 104

    Topics: Adrenal Cortex Hormones; Anemia; Anemia, Myelophthisic; Anticonvulsants; Blood Transfusion; Epilepsy

1963
THE INFANT WITH EPILEPSY.
    Southwestern medicine, 1963, Volume: 44

    Topics: Acetazolamide; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Birth Injuries; Classific

1963
[ETIOLOGY AND THERAPY OF STATUS EPILEPTICUS].
    Deutsche medizinische Wochenschrift (1946), 1963, Nov-08, Volume: 88

    Topics: Abortion, Septic; Anticonvulsants; Birth Injuries; Brain Injuries; Brain Neoplasms; Chloral Hydrate;

1963
DOSAGE OF PHENYTOIN AND PHENOBARBITAL IN CHILDREN.
    Danish medical bulletin, 1963, Volume: 10

    Topics: Blood Chemical Analysis; Child; Epilepsy; Fever; Humans; Phenobarbital; Phenytoin; Seizures

1963
DELAYED TOXICITY AND SERUM CONCENTRATIONS OF PHENYTOIN.
    Danish medical bulletin, 1963, Volume: 10

    Topics: Blood Chemical Analysis; Consciousness; Depression; Depressive Disorder; Epilepsy; Humans; Neurologi

1963
[QUANTITATIVE DETERMINATIONS OF DIPHENYLHYDANTOIN IN PATIENTS WITH EPILEPSY].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1963, Dec-15, Volume: 83

    Topics: Blood Chemical Analysis; Epilepsy; Phenytoin

1963
SUBNORMAL SERUM FOLATE AND MACROCYTOSIS ASSOCIATED WITH ANTICONVULSANT DRUG THERAPY.
    Blood, 1964, Volume: 23

    Topics: Anemia; Anemia, Macrocytic; Anticonvulsants; Biological Assay; Blood Chemical Analysis; Enterococcus

1964
[GENESIS, CLASSIFICATION AND THERAPY OF LOSS OF CONSCIOUSNESS].
    Monatsschrift fur Kinderheilkunde, 1963, Volume: 111

    Topics: Caffeine; Child; Classification; Electroencephalography; Epilepsy; Epilepsy, Absence; Humans; Oxyphe

1963
CONVULSIONS.
    Archives of dermatology, 1964, Volume: 89

    Topics: Black People; Diagnosis, Differential; Epilepsy; Humans; Intellectual Disability; Phenobarbital; Phe

1964
HYPERPLASIA GINGIVAE DIPHENYLHYDANTOINEA. A CLINICAL, HISTOLOGICAL, AND BIOCHEMICAL STUDY.
    Acta odontologica Scandinavica, 1963, Volume: 21

    Topics: Adolescent; Child; Collagen; Dentition; Epilepsy; Gingiva; Gingival Hyperplasia; Glycosaminoglycans;

1963
MEDICAL TREATMENT OF EPILEPSIES IN CHILDHOOD. A LONG-TERM SURVEY OF 801 PATIENTS.
    Epilepsia, 1963, Volume: 4

    Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child; Electroenc

1963
SOME INHIBITORY EFFECTS OF ATTENTIVE FACTORS ON EXPERIMENTAL EPILEPSY.
    Epilepsia, 1963, Volume: 4

    Topics: Acetylcholine; Aminobutyrates; Carboxy-Lyases; Cats; Electric Stimulation; Electroencephalography; E

1963
GINGIVAL HYPERPLASIA AND DILANTIN CONTENT OF SALIVA: A PILOT STUDY.
    Journal of the American Dental Association (1939), 1964, Volume: 68

    Topics: Adolescent; Chemistry Techniques, Analytical; Epilepsy; Gingiva; Gingival Hyperplasia; Humans; Hyper

1964
[INCREASE OF INTELLECTUAL EFFICIENCY BY ANTICONVULSIVE THERAPY IN LATENT DISPOSITION TO CONVULSIONS].
    Kinderarztliche Praxis, 1963, Volume: 31

    Topics: Anticonvulsants; Child; Electroencephalography; Epilepsy; Humans; Intelligence Tests; Phenytoin; Sei

1963
SOME OBSERVATIONS ON THE ELECTROGRAPHIC CORRELATES OF THE DECEREBRATE ATTACK.
    Electroencephalography and clinical neurophysiology, 1964, Volume: 16

    Topics: Child; Coma; Decerebrate State; Electroencephalography; Epilepsy; Humans; Hypoxia, Brain; Infusions,

1964
[PSEUDOCOLLAGENOSIS OR MALIGNANT PSEUDOLYMPHOMA?INJURIOUS EFFECT OF A HYDANTOIN DERIVATIVE].
    Schweizerische medizinische Wochenschrift, 1964, Jan-11, Volume: 94

    Topics: Adrenal Cortex Hormones; Biopsy; Diagnosis, Differential; Epilepsy; Erythema; Fever; Humans; Hydanto

1964
PSYCHOMOTOR VARIANT TYPE OF SEIZURE DISCHARGE.
    Neurology, 1963, Volume: 13

    Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, T

1963
CONVULSIVE EQUIVALENT SYNDROME OF CHILDHOOD.
    The Journal of pediatrics, 1964, Volume: 64

    Topics: Acetazolamide; Adolescent; Anticonvulsants; Autonomic Nervous System Diseases; Child; Chlorpromazine

1964
[FEBRILE CONVULSIONS IN CHILDREN. PROGNOSTIC STUDIES AND AN ATTEMPTED EVALUATION OF THE EFFECTS OF PROLONGED PROPHYLACTIC ANTIEPILEPSY TREATMENT. A PRELIMINARY REPORT].
    Ugeskrift for laeger, 1964, Feb-13, Volume: 126

    Topics: Child; Denmark; Epilepsy; Exanthema Subitum; Fever; Humans; Infant; Phenytoin; Prognosis; Respirator

1964
[SERUM PHENYTOIN CONCENTRATION IN EPILEPTIC OUTPATIENTS].
    Ugeskrift for laeger, 1964, Feb-13, Volume: 126

    Topics: Adolescent; Blood Chemical Analysis; Child; Denmark; Epilepsy; Geriatrics; Humans; Outpatients; Phen

1964
[TREATMENT OF EPILEPSY IN ADULTS. A BRIEF SURVEY OF THE CLINICAL PROBLEMS].
    Ugeskrift for laeger, 1964, Feb-13, Volume: 126

    Topics: Acetazolamide; Anticonvulsants; Blood Chemical Analysis; Chloral Hydrate; Data Collection; Electroen

1964
CONVULSIONS IN INFANCY AND CHILDHOOD.
    Pediatric clinics of North America, 1963, Volume: 10

    Topics: Anticonvulsants; Child; Electroencephalography; Encephalitis; Epilepsy; Epilepsy, Absence; Epilepsy,

1963
DIPHENYLHYDANTOIN AND PHENOBARBITAL. SERUM LEVELS IN CHILDREN.
    American journal of diseases of children (1960), 1964, Volume: 108

    Topics: Adolescent; Blood; Child; Drug Therapy; Epilepsy; Humans; Infant; Pharmacology; Phenobarbital; Pheny

1964
SEIZURES INDUCED BY MOVEMENT: A FORM OF REFLEX EPILEPSY.
    Lancet (London, England), 1964, Jun-27, Volume: 2, Issue:7348

    Topics: Adolescent; Athetosis; Cerebral Angiography; Diagnosis, Differential; Electroencephalography; Epilep

1964
[MEGALOBLASTIC ANEMIA PRODUCED BY ANTICONVULSANTS].
    Prensa medica argentina, 1963, Oct-25, Volume: 50

    Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Argentina; Barbiturates; Blood C

1963
[OBSERVATION ON TWO CASES OF EPILEPSIA CURSIVA].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1964, Volume: 66

    Topics: Adolescent; Atrophy; Barbiturates; Cerebral Cortex; Chlordiazepoxide; Dichlorphenamide; Electroencep

1964
SERUM DIPHENYLHYDANTOIN (PHENYTOIN) IN AMBULANT PATIENTS WITH EPILEPSY.
    Epilepsia, 1964, Volume: 5

    Topics: Adolescent; Biomedical Research; Blood; Child; Drug Therapy; Epilepsy; Epilepsy, Temporal Lobe; Epil

1964
REPORT ON THE ANTI-EPILEPTIC ACTION OF TEGRETOL.
    Epilepsia, 1964, Volume: 5

    Topics: Acetazolamide; Adolescent; Anticonvulsants; Biomedical Research; Carbamazepine; Child; Chlordiazepox

1964
ZARONTIN (ETHOSUXIMIDE) IN THE TREATMENT OF PETIT MAL AND RELATED DISORDERS.
    Epilepsia, 1964, Volume: 5

    Topics: Adolescent; Anticonvulsants; Biomedical Research; Child; Denmark; Drug Therapy; Epilepsy; Epilepsy,

1964
[ANTI-EPILEPTIC ACTIVITY OF TRINURIDE].
    La Presse medicale, 1964, Jul-04, Volume: 72

    Topics: Anticonvulsants; Epilepsy; Pharmacology; Phenobarbital; Phenytoin; Toxicology

1964
EFFECTS OF ANTICONVULSIVE MEDICATION ON VESTIBULAR FUNCTION. AN ELECTRONYSTAGMOGRAPHIC STUDY.
    The Journal of laryngology and otology, 1964, Volume: 78

    Topics: Electronystagmography; Epilepsy; Humans; Nystagmus, Pathologic; Pharmacology; Phenobarbital; Phenyto

1964
[DEMONSTRATION OF THE "TRANSFER FACTOR" IN HYDANTOIN ALLERGY PRESENTING AS SUBACUTE LUPUS ERYTHEMATOSUS IN GENUINE EPILEPSY].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1964, Volume: 15

    Topics: Anticonvulsants; Drug Eruptions; Drug Hypersensitivity; Epilepsy; Lupus Erythematosus, Systemic; Phe

1964
[REHABILITATION OF THE EPILEPTIC. CLINICAL EXPERIENCE WITH A POTENTIALIZED ANTICONVULSANT].
    Hospital (Rio de Janeiro, Brazil), 1964, Volume: 65

    Topics: Anticonvulsants; Barbiturates; Epilepsy; Humans; Mephobarbital; Phenobarbital; Phenytoin

1964
DRUG-INDUCED IN-VITRO STIMULATION OF PERIPHERAL LYMPHOCYTES.
    Lancet (London, England), 1964, Jun-20, Volume: 1, Issue:7347

    Topics: Antigen-Antibody Reactions; Child; Dermatitis; Drug Hypersensitivity; Epilepsy; Fever; Hepatomegaly;

1964
EXPERIMENTAL SUBCORTICAL EPILEPTIFORM FOCUS.
    Epilepsia, 1964, Volume: 5

    Topics: Aluminum; Amygdala; Cats; Electroencephalography; Epilepsy; Hippocampus; Pharmacology; Phenobarbital

1964
HINTS ON SEIZURE MANAGEMENT.
    GP, 1964, Volume: 30

    Topics: Anticonvulsants; Drug Therapy; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Hu

1964
IATROGENIC MEGALOBLASTIC ANAEMIA WITH NEUROLOGICAL COMPLICATIONS.
    Scottish medical journal, 1964, Volume: 9

    Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Brain Diseases; Cysticercosis; Drug Therapy; Epil

1964
[3 CASES OF TELEVISION EPILEPSY].
    Nihon Shonika Gakkai zasshi. Acta paediatrica Japonica, 1964, Volume: 68

    Topics: Child; Drug Therapy; Electroencephalography; Epilepsy; Epilepsy, Reflex; Humans; Phenobarbital; Phen

1964
NOTE ON THE INTERACTIONS OF AMPHETAMINE WITH ANTICONVULSANT DRUGS.
    Acta pharmacologica et toxicologica, 1964, Volume: 21

    Topics: Amphetamine; Amphetamines; Animals; Anticonvulsants; Electricity; Electroshock; Epilepsy; Epilepsy,

1964
ANESTHETIC MANAGEMENT OF THE PARTURIENT WITH INTRACRANIAL TUMOR.
    Obstetrics and gynecology, 1964, Volume: 24

    Topics: Anesthesia; Anesthesia, Endotracheal; Anesthesia, Spinal; Anesthetics; Angiography; Brain Neoplasms;

1964
[POSSIBILITIES OF COMBINED ANTICONVULSANT TREATMENT IN CHRONIC SEIZURES].
    Medizinische Klinik, 1964, Apr-24, Volume: 59

    Topics: Adolescent; Anticonvulsants; Child; Drug Therapy; Epilepsy; Humans; Infant; Infant, Newborn; Phenoba

1964
MEGALOBLASTIC ANEMIA AND NEUROLOGIC DISTURBANCES COMBINED WITH FOLIC ACID DEFICIENCY. OBSERVATIONS ON AN EPILEPTIC PATIENT TREATED WITH ANTICONVULSANTS.
    Acta medica Scandinavica, 1964, Volume: 176

    Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Avitaminosis; Barbiturates; Brai

1964
EFFECT OF DIPHENYLHYDANTOIN ON NEUROMUSCULAR SYNAPSE.
    Neurology, 1964, Volume: 14

    Topics: Electromyography; Epilepsy; Humans; Infant; Muscular Diseases; Neural Conduction; Neuromuscular Junc

1964
CONVULSIONS.
    Indian medical journal, 1964, Volume: 58

    Topics: Epilepsy; Humans; Infant; Paraldehyde; Phenytoin; Seizures; Toxicology

1964
TREATMENT OF HEADACHES IN CHILDREN.
    Modern treatment, 1964, Volume: 1

    Topics: Adolescent; Child; Drug Therapy; Epilepsy; Headache; Humans; Methysergide; Migraine Disorders; Pheno

1964
TEMPORAL LOBE EPILEPSY: A CLINICAL STUDY OF 47 CASES.
    Canadian Medical Association journal, 1964, Dec-12, Volume: 91

    Topics: Adolescent; Biomedical Research; Birth Injuries; Depression; Depressive Disorder; Diagnosis, Differe

1964
CHILD CARE IN GENERAL PRACTICE. CONVULSIONS IN INFANCY AND CHILDHOOD. II.
    British medical journal, 1965, Feb-20, Volume: 1, Issue:5433

    Topics: Acetazolamide; Anticonvulsants; Bromides; Child; Child Care; Chloral Hydrate; Diagnosis; Drug Therap

1965
DIPHENYLHYDANOIN-INDUCED HYPERSENSITIVITY REACTION.
    The Journal of pediatrics, 1965, Volume: 66

    Topics: Blood Cell Count; Child; Drug Eruptions; Drug Hypersensitivity; Drug Therapy; Epilepsy; Epilepsy, Te

1965
SODIUM DIPHENYLHYDANTOIN REACTION WITH EVIDENCE OF CIRCULATING ANTIBODIES.
    JAMA, 1965, Apr-12, Volume: 192

    Topics: Antibodies; Anticonvulsants; Drug Hypersensitivity; Drug Therapy; Epilepsy; Epilepsy, Tonic-Clonic;

1965
[TREATMENT OF EPILEPSY WITH 3-ETHOXYCARBO-5,5-DIPHENYLHYDANTOIN (P-6127), A NEW ANTICONVULSANT].
    No to shinkei = Brain and nerve, 1964, Volume: 16

    Topics: Anticonvulsants; Ataxia; Blood Chemical Analysis; Drug Therapy; Electroencephalography; Epilepsy; Ep

1964
PROBENECID (BENEMID) INTOXICATION WITH STATUS EPILEPTICUS.
    The American journal of medicine, 1965, Volume: 38

    Topics: Coma; Drug Therapy; Epilepsy; Gout; Phenobarbital; Phenytoin; Poisoning; Probenecid; Status Epilepti

1965
SERUM PHENYTOIN DETERMINATIONS IN EPILEPTICS.
    Epilepsia, 1964, Volume: 5

    Topics: Anticonvulsants; Blood Chemical Analysis; Child; Drug Therapy; Electroencephalography; Epilepsy; Hum

1964
NEUROLOGICAL PROBLEMS IN ADOLESCENCE WITH PARTICULAR ATTENTION TO SEIZURES.
    The Medical clinics of North America, 1965, Volume: 49

    Topics: Adolescent; Attention; Child; Child Behavior Disorders; Drug Therapy; Electroencephalography; Epilep

1965
MEGALOBLASTIC ANAEMIA ASSOCIATED WITH ANTICONVULSANT DRUGS: STUDIES ON A CASE WITH FOUR RELAPSES.
    Acta medica Scandinavica, 1965, Volume: 177

    Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Drug Therapy; Electrophoresis; Epilepsy;

1965
DIPHENYLHYDANTOIN ACTIVATED SEIZURES.
    Neurology, 1965, Volume: 15

    Topics: Drug Therapy; Electroencephalography; Epilepsy; Phenytoin; Seizures; Toxicology

1965
NEUROLOGICAL SEQUELAE FOLLOWING DILANTIN OVERDOSE IN A PATIENT AND IN EXPERIMENTAL ANIMALS.
    Neurology, 1965, Volume: 15

    Topics: Adolescent; Ataxia; Biomedical Research; Cats; Chlordiazepoxide; Drug Therapy; Epilepsy; Humans; Neu

1965
THE PERIODICALLY RECURRING FOCAL DISCHARGE.
    Epilepsia, 1965, Volume: 6

    Topics: Animals; Cerebrovascular Disorders; Child; Drug Therapy; Electrocardiography; Electroencephalography

1965
SYNDROME OF GINGIVAL HYPERPLASIA, HIRSUTISM, AND CONVULSIONS; DILANTIN INTOXICATION WITHOUT DILANTIN.
    The Journal of pediatrics, 1965, Volume: 67

    Topics: Ataxia; Brain Diseases; Child; Chlorpheniramine; Diagnosis, Differential; Diencephalon; Drug Therapy

1965
GINGIVAL HYPERPLASIA IN DILANTIN THERAPY FOR EPILEPTICS.
    Delaware medical journal, 1965, Volume: 37

    Topics: Drug Therapy; Epilepsy; Gingival Hyperplasia; Humans; Phenytoin; Toxicology

1965
[Leukemia in an epileptic treated with gardenal and dihydan; recovery; fatal mysoline poisoning with fatty degeneration of the liver and acute epithelial nephritis].
    Annales medico-psychologiques, 1955, Volume: 113 1, Issue:2

    Topics: Anticonvulsants; Barbiturates; Epilepsy; Humans; Hydantoins; Leukemia; Leukocytosis; Liver Diseases;

1955
Megaloblastic anaemia due to phenytoin sodium.
    British medical journal, 1955, Jul-23, Volume: 2, Issue:4933

    Topics: Anemia; Anemia, Megaloblastic; Epilepsy; Hydantoins; Phenytoin; Tracheophyta

1955
Recent experiences with parenteral dilantin.
    Epilepsia, 1959, Volume: 1

    Topics: Epilepsy; Phenytoin

1959
Diffusion tensor MRI and fiber tractography of cerebellar atrophy in phenytoin users.
    Epilepsia, 2003, Volume: 44, Issue:12

    Topics: Adult; Afferent Pathways; Anisotropy; Anticonvulsants; Atrophy; Cerebellum; Diagnosis, Differential;

2003
Influence of coadministered antiepileptic drugs on serum zonisamide concentrations in epileptic patients: quantitative analysis based on suitable transforming factor.
    Biological & pharmaceutical bulletin, 2003, Volume: 26, Issue:12

    Topics: Administration, Oral; Adolescent; Adult; Aging; Anticonvulsants; Biological Availability; Body Surfa

2003
CYP2C polymorphisms, phenytoin metabolism and gingival overgrowth in epileptic subjects.
    Life sciences, 2004, Jan-02, Volume: 74, Issue:7

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; C

2004
Validated high performance liquid chromatographic method for simultaneous determination of phenytoin, phenobarbital and carbamazepine in human serum.
    Arzneimittel-Forschung, 2003, Volume: 53, Issue:11

    Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Humans; Indicators a

2003
Spotlight on oxcarbazepine in epilepsy.
    CNS drugs, 2004, Volume: 18, Issue:1

    Topics: Adolescent; Anticonvulsants; Area Under Curve; Carbamazepine; Child; Child, Preschool; Clinical Tria

2004
Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism?
    Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:12

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Epilepsy; Female; Gest

2003
Oral tegafur/folinic acid chemotherapy decreases phenytoin efficacy.
    British journal of cancer, 2004, Feb-09, Volume: 90, Issue:3

    Topics: Administration, Oral; Anticonvulsants; Antimetabolites, Antineoplastic; Carcinoma; Drug Interactions

2004
What comes after dilantin?
    Psychoanalytic review, 1950, Volume: 37, Issue:4

    Topics: Epilepsy; Humans; Hydantoins; Phenytoin; Psychotherapy

1950
Comparative results in seizure control using phenobarbital, dilantin, and mesantoin.
    The American journal of psychiatry, 1950, Volume: 107, Issue:6

    Topics: Barbital; Epilepsy; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Seizures

1950
Dilantin hyperplasia.
    Military surgeon, 1951, Volume: 109, Issue:2

    Topics: Epilepsy; Gingiva; Humans; Hyperplasia; Phenytoin

1951
[Therapy of genuine epilepsy with sodium diphenylhydantoinate].
    Therapie der Gegenwart, 1951, Volume: 90, Issue:8

    Topics: Anions; Epilepsy; Humans; Ions; Phenytoin; Sodium; Sodium, Dietary

1951
The mode of action of sodium diphenylhydantoinate (dilantin) in epilepsy.
    The Journal of pharmacology and experimental therapeutics, 1951, Volume: 103, Issue:2

    Topics: Epilepsy; Hydantoins; Phenytoin

1951
Potentially inappropriate antiepileptic drugs for elderly patients with epilepsy.
    Journal of the American Geriatrics Society, 2004, Volume: 52, Issue:3

    Topics: Acetates; Aged; Amines; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Epilepsy; Female; Ga

2004
Acute visual dysfunction following phenytoin-induced toxicity.
    Acta neurologica Belgica, 2003, Volume: 103, Issue:4

    Topics: Adult; Anticonvulsants; Color Perception; Epilepsy; Evoked Potentials, Visual; Humans; Male; Optic N

2003
Interaction between anticonvulsants and human placental carnitine transporter.
    Epilepsia, 2004, Volume: 45, Issue:3

    Topics: Acetates; Amines; Aminoisobutyric Acids; Anticonvulsants; Carnitine; Carrier Proteins; Culture Techn

2004
Cost of epilepsy in patients attending a secondary-level hospital in India.
    Epilepsia, 2004, Volume: 45, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Efficiency, Organizational; Epilepsy; Hospital Costs; Hospitalizatio

2004
The effect of long-term antiepileptic treatment on serum cholesterol (TC, HDL, LDL) and triglyceride levels in adult epileptic patients on monotherapy.
    Medical science monitor : international medical journal of experimental and clinical research, 2004, Volume: 10, Issue:4

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cholesterol; Cholesterol, HDL; Cholesterol,

2004
Modulation of antiepileptic effect of phenytoin and carbamazepine by melatonin in mice.
    Methods and findings in experimental and clinical pharmacology, 2004, Volume: 26, Issue:2

    Topics: Animals; Anticonvulsants; Area Under Curve; Carbamazepine; Chromatography, High Pressure Liquid; Dis

2004
Clinical policy: Critical issues in the evaluation and management of adult patients presenting to the emergency department with seizures.
    Annals of emergency medicine, 2004, Volume: 43, Issue:5

    Topics: Adult; Anticonvulsants; Electroencephalography; Emergency Service, Hospital; Epilepsy; Humans; Pheny

2004
Phenytoin-induced gingival overgrowth in un-cooperated epilepsy patients.
    Yonsei medical journal, 2004, Apr-30, Volume: 45, Issue:2

    Topics: Adult; Anticonvulsants; Epilepsy; Gingival Overgrowth; Humans; Male; Oral Hygiene; Patient Complianc

2004
The role of seizures in reversible posterior leukoencephalopathy.
    Seizure, 2004, Volume: 13, Issue:4

    Topics: Anticonvulsants; Electroencephalography; Epilepsy; Female; Functional Laterality; Humans; Magnetic R

2004
The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats.
    Acta neurologica Belgica, 2004, Volume: 104, Issue:1

    Topics: Animals; Anticonvulsants; Cilastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Elec

2004
Activation of serum aminotransferases by pyridoxal-5' -phosphate in epileptic patients treated with anticonvulsant drugs.
    Clinical biochemistry, 2004, Volume: 37, Issue:8

    Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Carbamazepine; Drug Therapy, Combination;

2004
Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models.
    Journal of neural transmission (Vienna, Austria : 1996), 2004, Volume: 111, Issue:9

    Topics: Action Potentials; Animals; Anticonvulsants; Brain; Cobalt; Disease Models, Animal; Drug Combination

2004
Dosage recommendation of phenytoin for patients with epilepsy with different CYP2C9/CYP2C19 polymorphisms.
    Therapeutic drug monitoring, 2004, Volume: 26, Issue:5

    Topics: Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CYP2C19; Cytoc

2004
The use of 3,-methyl,5,phenylhydantoin (AC 114) in the treatment of epilepsy (a preliminary report).
    Bulletin of the Johns Hopkins Hospital, 1950, Volume: 86, Issue:6

    Topics: Epilepsy; Hydantoins; Phenytoin

1950
The outcome of initiation of antiepileptic drug monotherapy in primary care: a UK database survey.
    The British journal of general practice : the journal of the Royal College of General Practitioners, 2004, Volume: 54, Issue:507

    Topics: Aged; Anticonvulsants; Carbamazepine; Child, Preschool; Clinical Competence; Epilepsy; Family Practi

2004
Significance of MDR1 and multiple drug resistance in refractory human epileptic brain.
    BMC medicine, 2004, Oct-09, Volume: 2

    Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Anticonvulsants; Astrocytes; ATP Binding Cassette Tr

2004
Assessment of the epilepsy treatment gap in two cities of south-east of Brazil.
    Arquivos de neuro-psiquiatria, 2004, Volume: 62, Issue:3B

    Topics: Adult; Anticonvulsants; Brazil; Carbamazepine; Epilepsy; Health Services Accessibility; Health Servi

2004
Longer term outcome of children born to mothers with epilepsy.
    Journal of neurology, neurosurgery, and psychiatry, 2004, Volume: 75, Issue:11

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Fema

2004
Lower phenytoin serum levels in persons switched from brand to generic phenytoin.
    Neurology, 2004, Oct-26, Volume: 63, Issue:8

    Topics: Adult; Anticonvulsants; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Drugs, Generic; Epi

2004
Phenytoin use in elderly nursing home residents.
    The American journal of geriatric pharmacotherapy, 2003, Volume: 1, Issue:2

    Topics: Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Cross-Sectional Studies; Data Collection; Epi

2003
Hypogeusia as an adverse reaction of phenytoin.
    British journal of clinical pharmacology, 2004, Volume: 58, Issue:6

    Topics: Ageusia; Anticonvulsants; Epilepsy; Humans; Male; Middle Aged; Phenytoin

2004
[Association between genetic polymorphisms of CYP2C19 and CYP2C9 and phenytoin serum concentration].
    Zhonghua yi xue za zhi, 2004, Oct-17, Volume: 84, Issue:20

    Topics: Adolescent; Adult; Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Child; Child, Preschool; Cytochrome

2004
Isoforms of serum gamma-glutamyltransferase in epileptic patients treated with enzyme-inducing anticonvulsant drugs.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2004, Nov-15, Volume: 7, Issue:3

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; gamma-Glutamyltransferase; Humans; Isoenzym

2004
Influence of coadministered antiepileptic drugs on serum phenobarbital concentrations in epileptic patients: quantitative analysis based on a suitable transforming factor.
    Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:12

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Chil

2004
[Influence of psychotropic drugs on thrombocytes aggregation in patients with epilepsy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2004, Volume: 104, Issue:11

    Topics: Adolescent; Adult; Barbiturates; Carbamazepine; Epilepsy; Humans; In Vitro Techniques; Lamotrigine;

2004
Mechanisms of edema after gamma knife surgery for meningiomas. Report of two cases.
    Journal of neurosurgery, 2005, Volume: 102 Suppl

    Topics: Adolescent; Adult; Anti-Inflammatory Agents; Anticonvulsants; Brain Edema; Dexamethasone; Epilepsy;

2005
Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy.
    Annals of neurology, 2005, Volume: 57, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Bone and Bones; Bone Remodeling; Carbamazepine; Epilepsy; Female

2005
Phenytoin intoxication in critically ill patients.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 45, Issue:1

    Topics: Epilepsy; Face; Female; Humans; Liver Failure, Acute; Middle Aged; Phenytoin

2005
Letter to the neurology editor.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2005, Volume: 12, Issue:2

    Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden; Epilepsy; Humans; Myocardial Infarction

2005
Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Apr-12, Volume: 102, Issue:15

    Topics: Adolescent; Adult; Aged; Alleles; Amino Acid Sequence; Anticonvulsants; Aryl Hydrocarbon Hydroxylase

2005
Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics.
    Neurology, 2005, Apr-12, Volume: 64, Issue:7

    Topics: Anticonvulsants; Carbamazepine; Causality; Epilepsy; Germany; Humans; Incidence; Inpatients; Lamotri

2005
A fragile site at 10q23 (FRA10A) in a phenytoin-exposed fetus: a case report and review of the literature.
    Prenatal diagnosis, 2005, Volume: 25, Issue:4

    Topics: Adult; Amniocentesis; Anticonvulsants; Cells, Cultured; Chromosome Deletion; Chromosome Fragile Site

2005
Lower phenytoin serum levels in persons switched from brand to generic phenytoin.
    Neurology, 2005, Apr-26, Volume: 64, Issue:8

    Topics: Anticonvulsants; Drug and Narcotic Control; Drugs, Generic; Epilepsy; Humans; Legislation, Pharmacy;

2005
Lower phenytoin serum levels in persons switched from brand to generic phenytoin.
    Neurology, 2005, Apr-26, Volume: 64, Issue:8

    Topics: Anticonvulsants; Conflict of Interest; Drug Industry; Drugs, Generic; Epilepsy; Humans; Phenytoin; T

2005
Gene variants affect response to antiepileptic drugs.
    The Lancet. Neurology, 2005, Volume: 4, Issue:5

    Topics: Alternative Splicing; Anticonvulsants; Carbamazepine; Cytochrome P-450 Enzyme System; Drug Resistanc

2005
An epilepsy mutation in the beta1 subunit of the voltage-gated sodium channel results in reduced channel sensitivity to phenytoin.
    Epilepsy research, 2005, Volume: 64, Issue:3

    Topics: Animals; CHO Cells; Cricetinae; Epilepsy; Humans; Mutation; NAV1.3 Voltage-Gated Sodium Channel; Ner

2005
Seizures following reduction in phenytoin level after orally administered folic acid.
    Neurology, 2005, Jun-14, Volume: 64, Issue:11

    Topics: Administration, Oral; Anemia, Macrocytic; Anticonvulsants; Dose-Response Relationship, Drug; Down-Re

2005
Fit for a fracture.
    The Medical journal of Australia, 2005, Aug-15, Volume: 183, Issue:4

    Topics: Anticonvulsants; Epilepsy; Ergocalciferols; Female; Femoral Neck Fractures; Follow-Up Studies; Fract

2005
Lower phenytoin serum levels in persons switched from brand to generic phenytoin.
    Neurology, 2005, Aug-23, Volume: 65, Issue:4

    Topics: Anticonvulsants; Clinical Trials as Topic; Conflict of Interest; Disclosure; Drug Industry; Epilepsy

2005
Lower phenytoin serum levels in persons switched from brand to generic phenytoin.
    Neurology, 2005, Aug-23, Volume: 65, Issue:4

    Topics: Anticonvulsants; Bone Marrow Transplantation; Busulfan; Epilepsy; Humans; Phenytoin; Seizures; Thera

2005
Lower phenytoin serum levels in persons switched from brand to generic phenytoin.
    Neurology, 2005, Aug-23, Volume: 65, Issue:4

    Topics: Anticonvulsants; Clinical Protocols; Clinical Trials as Topic; Epilepsy; Humans; Phenytoin; Reproduc

2005
Lower phenytoin serum levels in persons switched from brand to generic phenytoin.
    Neurology, 2005, Aug-23, Volume: 65, Issue:4

    Topics: Anticonvulsants; Clinical Protocols; Clinical Trials as Topic; Drug Administration Routes; Epilepsy;

2005
Norfluoxetine and fluoxetine have similar anticonvulsant and Ca2+ channel blocking potencies.
    Brain research bulletin, 2005, Sep-30, Volume: 67, Issue:1-2

    Topics: Animals; Anticonvulsants; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signa

2005
RLIP76, a non-ABC transporter, and drug resistance in epilepsy.
    BMC neuroscience, 2005, Sep-27, Volume: 6

    Topics: Adolescent; Adult; Animals; ATP-Binding Cassette Transporters; Child; Child, Preschool; Drug Resista

2005
Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats.
    Epilepsia, 2005, Volume: 46, Issue:10

    Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Casse

2005
Treatment delay and the risk of prolonged status epilepticus.
    Neurology, 2005, Oct-25, Volume: 65, Issue:8

    Topics: Administration, Rectal; Anticonvulsants; Benzodiazepines; Child, Preschool; Clinical Protocols; Dise

2005
Improvement of oligoasthenozoospermia in epileptic patients on switching anti-epilepsy medication from sodium valproate to phenytoin.
    Scandinavian journal of urology and nephrology, 2005, Volume: 39, Issue:5

    Topics: Adult; Anticonvulsants; Epilepsy; Follow-Up Studies; Humans; Male; Oligospermia; Phenytoin; Sperm Co

2005
[Anticonvulsive pharmacotherapy may aggravate epilepsy course].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2005, Volume: 105, Issue:10

    Topics: Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy;

2005
Benign angiopathy of the central nervous system associated with phenytoin intoxication.
    Brain & development, 2006, Volume: 28, Issue:5

    Topics: Adult; Anticonvulsants; Cerebral Angiography; Epilepsy; Humans; Male; Paresis; Phenytoin; Vascular D

2006
Introduction to the International Geriatric Epilepsy Symposium (IGES).
    Epilepsy research, 2006, Volume: 68 Suppl 1

    Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Brain Diseases; Epilepsy; Geriatrics; Homes for the

2006
Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, vitamin B12, folic acid and vitamin B6.
    Seizure, 2006, Volume: 15, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Epilepsy; Female; Folic Aci

2006
Epileptic seizures superimposed on catatonic stupor.
    Epilepsia, 2006, Volume: 47, Issue:4

    Topics: Aged; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Catatonia; Combined Modality Therapy;

2006
Physical growth and psychomotor development of infants exposed to antiepileptic drugs in utero.
    Neurology India, 2006, Volume: 54, Issue:1

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Growth; Humans; Infant; Maternal Age; Motor Activity; Pari

2006
[Odinophagia and cutaneous lesions in patient with cerebral metastases].
    Revista clinica espanola, 2006, Volume: 206, Issue:5

    Topics: Aged; Anticonvulsants; Back; Brain Neoplasms; Cyclosporine; Dermis; Epilepsy; Fatal Outcome; Humans;

2006
[Rapid analysis of antiepileptic drugs in human plasma by micellar electrokinetic capillary chromatography].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:3

    Topics: Anticonvulsants; Buffers; Carbamazepine; Chromatography, Micellar Electrokinetic Capillary; Clonazep

2006
Effect of piperine on the steady-state pharmacokinetics of phenytoin in patients with epilepsy.
    Phytotherapy research : PTR, 2006, Volume: 20, Issue:8

    Topics: Adult; Alkaloids; Anticonvulsants; Area Under Curve; Benzodioxoles; Biological Availability; Dose-Re

2006
Seizure disorder in a professional American football player.
    Current sports medicine reports, 2006, Volume: 5, Issue:4

    Topics: Adult; Anticonvulsants; Dietary Supplements; Electroencephalography; Epilepsy; Football; Humans; Hyp

2006
Phenytoin-induced DRESS with cross-reactivity to carbamazepine in a 10-year-old Indian child.
    Clinical and experimental dermatology, 2006, Volume: 31, Issue:5

    Topics: Anticonvulsants; Blood Chemical Analysis; Carbamazepine; Child; Drug Eruptions; Eosinophilia; Epilep

2006
Antiepileptic TDM pattern at a tertiary care hospital in India.
    Nepal Medical College journal : NMCJ, 2006, Volume: 8, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; India; Pharmacology, Clinical; Ph

2006
Epilepsy in the elderly.
    Epilepsia, 2006, Volume: 47 Suppl 1

    Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Anticonvulsants; Comorbidity; Drug Costs; Drug Int

2006
Polymorphic variants of the multidrug resistance gene Mdr1a and response to antiepileptic drug treatment in the kindling model of epilepsy.
    European journal of pharmacology, 2006, Nov-21, Volume: 550, Issue:1-3

    Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transp

2006
Toxic epidermal necrolysis in a mother and fetus.
    Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:5 Suppl

    Topics: Adolescent; Anticonvulsants; Biopsy; Epilepsy; Female; Fetal Death; Fetus; Humans; Infectious Diseas

2006
Free phenytoin concentration measurement in brain extracellular fluid: a pilot study.
    British journal of neurosurgery, 2006, Volume: 20, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Brain Chemistry; Brain Injuries; Epilepsy; Extracellular Fluid;

2006
Is oral azithromycin effective for the treatment of phenytoin-induced gingival overgrowth in epileptic patients?
    Medical hypotheses, 2007, Volume: 69, Issue:5

    Topics: Administration, Oral; Anti-Bacterial Agents; Anticonvulsants; Azithromycin; Drug Interactions; Epile

2007
Epilepsy, parkinsonism, and neuroleptic malignant syndrome in a child.
    Journal of child neurology, 2006, Volume: 21, Issue:12

    Topics: Anticonvulsants; Antiparkinson Agents; Aspartic Acid; Basal Ganglia; Benzothiazoles; Carbamazepine;

2006
Epilepsy and antiepileptic drug use in elderly people as risk factors for dementia.
    Journal of the neurological sciences, 2007, Jan-31, Volume: 252, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Anticonvulsants; Cohort Studies; Epilepsy; Female

2007
Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model.
    Neuroscience letters, 2007, Feb-14, Volume: 413, Issue:2

    Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, M

2007
Cerebral atrophy and skull thickening due to chronic phenytoin therapy.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2007, Jan-30, Volume: 176, Issue:3

    Topics: Adult; Anticonvulsants; Atrophy; Cerebellar Diseases; Diagnosis, Differential; Epilepsy; Female; Hum

2007
Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese.
    Therapeutic drug monitoring, 2007, Volume: 29, Issue:1

    Topics: Adult; Algorithms; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CY

2007
Evaluation of therapeutic drug level monitoring of phenobarbital, phenytoin and carbamazepine in Iranian epileptic patients.
    International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Monitoring; Drug Therapy, Combination; Epile

2007
Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs.
    Epilepsia, 2007, Volume: 48, Issue:3

    Topics: Anticonvulsants; Astrocytes; Blood-Brain Barrier; Brain; Cells, Cultured; Coculture Techniques; Diaz

2007
Macroprolactinomas and epilepsy.
    Clinical endocrinology, 2007, Volume: 66, Issue:4

    Topics: Adult; Anticonvulsants; Dopamine Agonists; Drug Therapy, Combination; Epilepsy; Epilepsy, Temporal L

2007
Intestinal expression of cytochrome P450 enzymes and ABC transporters and carbamazepine and phenytoin disposition.
    Acta neurologica Scandinavica, 2007, Volume: 115, Issue:4

    Topics: Adult; Aged; Anticonvulsants; ATP-Binding Cassette Transporters; Carbamazepine; Cytochrome P-450 Enz

2007
Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:1

    Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri

2007
Antiepileptic drugs prevent changes induced by pilocarpine model of epilepsy in brain ecto-nucleotidases.
    Neurochemical research, 2007, Volume: 32, Issue:6

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphatases; Adenosine Triphosphate; A

2007
Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy.
    Epilepsia, 2007, Volume: 48, Issue:4

    Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Trans

2007
Diminished response of CA1 neurons to antiepileptic drugs in chronic epilepsy.
    Epilepsia, 2007, Volume: 48, Issue:7

    Topics: Action Potentials; Animals; Anticonvulsants; Carbamazepine; Chronic Disease; Dentate Gyrus; Disease

2007
The natural history and treatment of epilepsy in a murine model of tuberous sclerosis.
    Epilepsia, 2007, Volume: 48, Issue:8

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalograp

2007
Rash from antiepileptic drugs: influence by gender, age, and learning disability.
    Epilepsia, 2007, Volume: 48, Issue:7

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Comorbidity; Drug Eruptions; Epileps

2007
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
    Epilepsia, 2007, Volume: 48, Issue:5

    Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil

2007
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
    Epilepsia, 2007, Volume: 48, Issue:5

    Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil

2007
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
    Epilepsia, 2007, Volume: 48, Issue:5

    Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil

2007
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
    Epilepsia, 2007, Volume: 48, Issue:5

    Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil

2007
Therapeutic drug monitoring and clinical outcomes in epileptic Egyptian patients: a gene polymorphism perspective study.
    Therapeutic drug monitoring, 2007, Volume: 29, Issue:3

    Topics: Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transpor

2007
Phenytoin but not valproate directly affected in vitro trophoblast differentiation.
    European journal of obstetrics, gynecology, and reproductive biology, 2008, Volume: 137, Issue:1

    Topics: Anticonvulsants; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Epilepsy;

2008
Contributions of CYP2C9/CYP2C19 genotypes and drug interaction to the phenytoin treatment in the Korean epileptic patients in the clinical setting.
    Journal of biochemistry and molecular biology, 2007, May-31, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; Bayes Theorem

2007
Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock.
    Epilepsy & behavior : E&B, 2007, Volume: 11, Issue:1

    Topics: Acetamides; Algorithms; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease

2007
[Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy].
    Actas dermo-sifiliograficas, 2007, Volume: 98, Issue:7

    Topics: Adenocarcinoma; Aged; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Combined Modality Therapy;

2007
[Drug-induced hypersensitivity due to phenytoin].
    No to hattatsu = Brain and development, 2007, Volume: 39, Issue:5

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Hypersensitivity; Epilepsy; Humans; Male;

2007
A painful gum.
    Australian family physician, 2007, Volume: 36, Issue:9

    Topics: Anticonvulsants; Epilepsy; Family Practice; Gingiva; Gingival Hyperplasia; Humans; Hygiene; Male; Mi

2007
Preliminary explorations of the role of mitochondrial proteins in refractory epilepsy: some findings from comparative proteomics.
    Journal of neuroscience research, 2007, Nov-01, Volume: 85, Issue:14

    Topics: Animals; Anticonvulsants; Databases, Factual; Disease Models, Animal; Electric Stimulation; Electrop

2007
[Influence of repeated seizures and large dosage anti-epileptic drug on phosphorylated cAMP response element binding protein in rat's hippocampus and effect of Caoguo Zhimu Decoction].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2007, Volume: 27, Issue:9

    Topics: Animals; Cognition Disorders; Cyclic AMP Response Element-Binding Protein; Drugs, Chinese Herbal; Ep

2007
Undetectable phenytoin serum levels by an automated particle-enhanced turbidimetric inhibition immunoassay in a patient with monoclonal IgM lambda.
    Clinica chimica acta; international journal of clinical chemistry, 2008, Volume: 389, Issue:1-2

    Topics: Aged; Anticonvulsants; Automation; Epilepsy; Female; Humans; Immunoassay; Immunoglobulin M; Paraprot

2008
Temporal pattern of oxcarbazepine and phenytoin withdrawal seizures during epilepsy monitoring.
    Epilepsy research, 2008, Volume: 79, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Electroencephalography; Epi

2008
Phenytoin toxicity: an easily missed cause of cerebellar syndrome.
    Journal of clinical pharmacy and therapeutics, 2008, Volume: 33, Issue:2

    Topics: Aged; Anticonvulsants; Cerebellar Diseases; Epilepsy; Humans; Male; Middle Aged; Phenytoin

2008
Contraindications to phenytoin in emergency department patients with seizures.
    The Journal of emergency medicine, 2009, Volume: 37, Issue:4

    Topics: Anticonvulsants; Contraindications; Emergency Service, Hospital; Epilepsy; Female; Humans; Levetirac

2009
Simultaneous toxicities in a child on multiple anticonvulsants.
    Journal of child neurology, 2008, Volume: 23, Issue:9

    Topics: Anticonvulsants; Bone Marrow; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Child, P

2008
Bone health.
    Neurology, 2008, Apr-29, Volume: 70, Issue:18

    Topics: Adult; Anticonvulsants; Bone Diseases, Metabolic; Epilepsy; Female; Humans; Patient Dropouts; Phenyt

2008
Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy.
    Neurology, 2008, Apr-29, Volume: 70, Issue:18

    Topics: Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Biomarkers; Bone Density; Bone Diseases, M

2008
Association between SCN1A polymorphism and carbamazepine-resistant epilepsy.
    British journal of clinical pharmacology, 2008, Volume: 66, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Female; Genotype;

2008
Generalized tonic-clonic seizures after acute oxcarbazepine withdrawal.
    Neurology, 2008, May-27, Volume: 70, Issue:22 Pt 2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged; Oxca

2008
Post-hemiplegic epilepsy in the elderly.
    British medical journal, 1967, Jan-28, Volume: 1, Issue:5534

    Topics: Aged; Epilepsy; Female; Hemiplegia; Humans; Intracranial Embolism and Thrombosis; Male; Middle Aged;

1967
Epilepsy--facts and fancy.
    GP, 1967, Volume: 35, Issue:4

    Topics: Electroencephalography; Epilepsy; Humans; Phenobarbital; Phenytoin

1967
The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine.
    Archives of neurology, 1967, Volume: 16, Issue:6

    Topics: Acetazolamide; Adult; Aged; Alcoholism; Amitriptyline; Chlordiazepoxide; Chlorpromazine; Chromatogra

1967
Movement epilepsy. Two case reports with photographs of the typical movements.
    Bulletin of the Los Angeles neurological societies, 1967, Volume: 32, Issue:1

    Topics: Adolescent; Electroencephalography; Epilepsy; Humans; Male; Movement; Movement Disorders; Phenytoin

1967
The epidemiology of drug-induced systemic lupus erythematosus.
    Arthritis and rheumatism, 1967, Volume: 10, Issue:5

    Topics: Adolescent; Adult; Aged; Child; Epilepsy; Female; Heart Diseases; Humans; Hydralazine; Hypertension;

1967
Serum creatine phosphokinase activity in epilepsy. Clinical and experimental studies.
    Neurology, 1967, Volume: 17, Issue:11

    Topics: Animals; Child; Creatine Kinase; Electroshock; Epilepsy; Female; Gallamine Triethiodide; Humans; Mal

1967
Epilepsy induced by cardiac pacemaker.
    JAMA, 1967, May-08, Volume: 200, Issue:6

    Topics: Aged; Amobarbital; Digoxin; Epilepsy; Female; Humans; Nerve Crush; Pacemaker, Artificial; Phenobarbi

1967
[Motor activity after diphenylhydantoin intoxication].
    Der Nervenarzt, 1967, Volume: 38, Issue:11

    Topics: Adult; Cerebellum; Electroencephalography; Epilepsy; Humans; Male; Motor Activity; Movement Disorder

1967
Phenytoin (Dilantin) intoxication.
    Acta neurologica Scandinavica, 1967, Volume: 43, Issue:4

    Topics: Adolescent; Adult; Aged; Anorexia Nervosa; Ataxia; Child; Epilepsy; Female; Humans; Male; Mental Dis

1967
Anticonvulsant therapy and its possible consequences on peripheral nervous system: a neurographic study.
    Epilepsia, 1984, Volume: 25, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Neural Conduction; Peripheral Nerves; Peripheral N

1984
Anticonvulsant drug therapy in human pregnancy: effects on serum concentrations of vitamin D metabolites in maternal and cord blood.
    American journal of obstetrics and gynecology, 1984, Oct-01, Volume: 150, Issue:3

    Topics: 24,25-Dihydroxyvitamin D 3; Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Calcifediol; C

1984
Phenytoin toxicity secondary to cimetidine administration.
    The Medical journal of Australia, 1984, Oct-27, Volume: 141, Issue:9

    Topics: Aged; Cimetidine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Peptic Ulc

1984
The effects of diphenylhydantoin on the relationship between high-density lipoprotein cholesterol and several biochemical assays.
    Clinica chimica acta; international journal of clinical chemistry, 1980, Mar-14, Volume: 102, Issue:1

    Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Australia; Cholesterol; Epilepsy; Fasting; Female; ga

1980
Psychiatric implications of anticonvulsant drugs.
    The Journal of clinical psychiatry, 1980, Volume: 41, Issue:9

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Dose-Response Relationship, Dr

1980
[Effect of barbexaclone treatment on thyroid function in epileptic children and juveniles (author's transl)].
    Der Nervenarzt, 1980, Volume: 51, Issue:10

    Topics: Adolescent; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phenyt

1980
Transfer from multiple to single antiepileptic drug therapy.
    Lancet (London, England), 1981, Jan-24, Volume: 1, Issue:8213

    Topics: Adult; Anticonvulsants; Drug Administration Schedule; Epilepsy; Female; Humans; Male; Middle Aged; P

1981
Effects of phenytoin on serum gamma-glutamyl transpeptidase activity.
    Epilepsia, 1981, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Dose-Response Relationship, Drug; Enz

1981
Once-a-day drug regimen for psychiatric patients.
    American family physician, 1981, Volume: 24, Issue:4

    Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Anxiety; Depressive Disorder; Drug Administratio

1981
Choice of anticonvulsants in epilepsy.
    Indian pediatrics, 1981, Volume: 18, Issue:5

    Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool

1981
The influence of antiepileptic drugs on the electroencephalogram: a review of controlled clinical studies.
    Electroencephalography and clinical neurophysiology. Supplement, 1982, Volume: 36

    Topics: Anti-Anxiety Agents; Anticonvulsants; Brain; Carbamazepine; Clonazepam; Electroencephalography; Epil

1982
[Rise in gamma-GT during anticonvulsive therapy].
    Wiener klinische Wochenschrift, 1982, Nov-12, Volume: 94, Issue:21

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combinatio

1982
Pharmacokinetics of antiepileptic drugs.
    Acta neurologica Scandinavica. Supplementum, 1983, Volume: 97

    Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool

1983
Pharmacodynamic factors in the occurrence of psychiatric symptoms among patients with epilepsy.
    Folia psychiatrica et neurologica japonica, 1983, Volume: 37, Issue:3

    Topics: Anticonvulsants; Barbiturates; Carbamazepine; Epilepsy; Folic Acid; Humans; Kinetics; Mental Disorde

1983
A rapid gas liquid chromatography method for simultaneous determination of various anticonvulsants.
    Journal of neurology, 1980, Volume: 223, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Drug Therapy, Combination; Epilepsy; Humans; Ph

1980
Quantitative analysis of training, sleep EEG and clinical response to EEG operant conditioning in epileptics.
    Electroencephalography and clinical neurophysiology, 1980, Volume: 49, Issue:5-6

    Topics: Adolescent; Adult; Biofeedback, Psychology; Conditioning, Operant; Electroencephalography; Electromy

1980
The reversibility of phenytoin-induced IgA deficiency.
    Journal of neurology, 1981, Volume: 226, Issue:1

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Child; Epilepsy; Female; Humans; IgA Deficiency; Immu

1981
Plasma concentrations of valproate during maintenance therapy in epileptic children.
    Journal of neurology, 1982, Volume: 228, Issue:2

    Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Epilepsy, A

1982
Plasma arginine vasopressin concentrations in epileptics under monotherapy.
    Journal of neurology, 1983, Volume: 230, Issue:3

    Topics: Adult; Anticonvulsants; Arginine Vasopressin; Carbamazepine; Epilepsy; Humans; Phenytoin; Primidone;

1983
Diabetes mellitus in a mongoloid child with chronic diphenylhydantoin therapy.
    Acta paediatrica Scandinavica, 1982, Volume: 71, Issue:3

    Topics: Child; Diabetes Mellitus, Type 1; Down Syndrome; Epilepsy; Female; Humans; Phenytoin; Risk

1982
[Hodgkin's disease in an epileptic treated with hydantoins].
    Presse medicale (Paris, France : 1983), 1983, May-28, Volume: 12, Issue:23

    Topics: Adult; Epilepsy; Hodgkin Disease; Humans; Male; Phenytoin

1983
Acne and anticonvulsants.
    British medical journal (Clinical research ed.), 1983, Dec-03, Volume: 287, Issue:6406

    Topics: Acne Vulgaris; Adolescent; Adult; Aged; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged

1983
Serum anticonvulsant concentrations and the risk of drug induced skin eruptions.
    Journal of neurology, neurosurgery, and psychiatry, 1984, Volume: 47, Issue:6

    Topics: Carbamazepine; Craniotomy; Drug Eruptions; Epilepsy; Humans; Phenytoin; Postoperative Complications

1984
Epilepsy and the management of dental disease.
    Dental update, 1984, Volume: 11, Issue:7

    Topics: Dental Care for Disabled; Epilepsy; Gingival Hyperplasia; Humans; Phenytoin

1984
Side effects of antiepileptic drugs: a peripheral neuropathy due to diphenylhydantoin (DPH) intoxication.
    Folia psychiatrica et neurologica japonica, 1980, Volume: 34, Issue:3

    Topics: Adolescent; Adult; Aged; Electromyography; Epilepsy; Female; Humans; Male; Middle Aged; Peripheral N

1980
Peripheral neuropathy in epileptic patients.
    Neurology, 1981, Volume: 31, Issue:7

    Topics: Epilepsy; H-Reflex; Humans; Neural Conduction; Peripheral Nervous System Diseases; Peroneal Nerve; P

1981
Lack of effect of phenytoin on functions related to Na+,K+-ATPase activity of the intact erythrocytes of epileptic patients.
    British journal of clinical pharmacology, 1981, Volume: 12, Issue:1

    Topics: Digoxin; Epilepsy; Erythrocyte Membrane; Erythrocytes; Humans; Phenytoin; Sodium-Potassium-Exchangin

1981
[Survival period of patients with gliomata or glioblastomata under anti-convulsive therapy (author's transl)].
    Der Nervenarzt, 1981, Volume: 52, Issue:10

    Topics: Adult; Brain Neoplasms; Epilepsy; Female; Glioblastoma; Glioma; Humans; Male; Phenytoin; Prognosis

1981
Peripheral neuropathy in children on long-term phenytoin therapy.
    Brain & development, 1981, Volume: 3, Issue:4

    Topics: Adolescent; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Long-Term Care; Male;

1981
Phenytoin prolongs far-field somatosensory and auditory evoked potential interpeak latencies.
    Neurology, 1982, Volume: 32, Issue:1

    Topics: Acoustic Stimulation; Auditory Pathways; Dose-Response Relationship, Drug; Electric Stimulation; Epi

1982
Central excitatory properties of delta 9-tetrahydrocannabinol and its metabolites in iron-induced epileptic rats.
    Neuropharmacology, 1982, Volume: 21, Issue:1

    Topics: Animals; Cannabidiol; Central Nervous System; Dronabinol; Electrophysiology; Epilepsy; Iron; Male; P

1982
Peripheral neuropathy in epileptics.
    Neurology, 1982, Volume: 32, Issue:4

    Topics: Animals; Epilepsy; Humans; Peripheral Nervous System Diseases; Phenytoin; Rats

1982
Cytomegalovirus antibodies in epileptics receiving diphenylhydantoin.
    Acta neurologica Scandinavica, 1982, Volume: 66, Issue:5

    Topics: Adolescent; Adult; Antibodies, Viral; Antibody Formation; Cytomegalovirus; Cytomegalovirus Infection

1982
Lack of interaction between ranitidine and phenytoin.
    British journal of clinical pharmacology, 1983, Volume: 15, Issue:4

    Topics: Drug Interactions; Epilepsy; Furans; Humans; Phenytoin; Ranitidine

1983
Peripheral nerve damage in epileptic patients treated with phenytoin.
    East African medical journal, 1983, Volume: 60, Issue:1

    Topics: Adolescent; Adult; Epilepsy; Female; Humans; Male; Middle Aged; Peripheral Nervous System Diseases;

1983
The treatable epilepsies.
    The New England journal of medicine, 1983, Dec-08, Volume: 309, Issue:23

    Topics: Adrenocorticotropic Hormone; Child; Epilepsy; Humans; Phenytoin; Spasms, Infantile; Valproic Acid

1983
[Side-effects of phenytoin and carbamazepine on electrophysiologic functions of the peripheral and central nervous system].
    Der Nervenarzt, 1983, Volume: 54, Issue:10

    Topics: Brain; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalog

1983
Variability of phenytoin protein binding in epileptic patients.
    Archives of neurology, 1983, Volume: 40, Issue:8

    Topics: Epilepsy; Humans; Immunoenzyme Techniques; Phenytoin; Protein Binding; Retrospective Studies; Ultraf

1983
Landmark article Sept 17, 1938: Sodium diphenyl hydantoinate in the treatment of convulsive disorders. By H. Houston Merritt and Tracy J. Putnam.
    JAMA, 1984, Feb-24, Volume: 251, Issue:8

    Topics: Adolescent; Adult; Epilepsy; History, 20th Century; Humans; Middle Aged; Phenytoin; United States

1984
Landmark perspective: Introduction of sodium diphenyl hydantoinate.
    JAMA, 1984, Feb-24, Volume: 251, Issue:8

    Topics: Epilepsy; History, 20th Century; Humans; Phenytoin; United States

1984
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled?
    Acta neurologica Scandinavica. Supplementum, 1983, Volume: 94

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo

1983
Serum folate concentrations during pregnancy in women with epilepsy: relation to antiepileptic drug concentrations, number of seizures, and fetal outcome.
    British medical journal (Clinical research ed.), 1983, Aug-27, Volume: 287, Issue:6392

    Topics: Carbamazepine; Congenital Abnormalities; Epilepsy; Female; Fetal Death; Folic Acid; Humans; Phenobar

1983
Drugs for epilepsy.
    The Medical letter on drugs and therapeutics, 1983, Sep-02, Volume: 25, Issue:643

    Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Humans; Phenobarbital; Phenytoin; Statu

1983
Treatment of the nonconvulsive epilepsies.
    Epilepsia, 1983, Volume: 24 Suppl 1

    Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Humans; Phenobarbi

1983
[Myasthenic syndrome following long-term diphenylhydantoin therapy].
    Der Nervenarzt, 1983, Volume: 54, Issue:8

    Topics: Adult; Electromyography; Epilepsy; Female; Humans; Long-Term Care; Myasthenia Gravis; Phenytoin

1983
[Role of the brain stem in the modification of epileptic activity in sleep states].
    Psychiatrie, Neurologie und medizinische Psychologie. Beihefte, 1983, Volume: 29

    Topics: Adolescent; Adult; Aged; Brain Stem; Child; Child, Preschool; Electroencephalography; Epilepsy; Evok

1983
[Pharmacotherapy of epilepsy--current problems and controversies].
    Fortschritte der Neurologie-Psychiatrie, 1983, Volume: 51, Issue:11

    Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy,

1983
Should we routinely measure free plasma phenytoin concentration?
    British journal of clinical pharmacology, 1984, Volume: 17, Issue:1

    Topics: Adolescent; Adult; Aged; Blood Proteins; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Pro

1984
Unnecessary polypharmacy in patients with frequent seizures.
    Acta neurologica Scandinavica, 1984, Volume: 69, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Drug Therapy, Combination; Epi

1984
Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy.
    Acta neurologica Scandinavica. Supplementum, 1983, Volume: 97

    Topics: Abnormalities, Drug-Induced; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Endocrine Syst

1983
Hepatic toxicity of antiepileptic drugs: a review.
    Acta neurologica Scandinavica. Supplementum, 1983, Volume: 97

    Topics: Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Energy Metabolism; Epilepsy;

1983
Pituitary responsiveness to gonadotrophin-releasing and thyrotrophin-releasing hormones in epileptic patients receiving carbamazepine or phenytoin.
    Clinical endocrinology, 1984, Volume: 20, Issue:2

    Topics: Adult; Carbamazepine; Epilepsy; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone

1984
Lowering effect of diphenylhydantoin on serum free thyroxine and thyroxine binding globulin (TBG).
    Acta endocrinologica, 1984, Volume: 105, Issue:4

    Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Phenytoin;

1984
Antiepileptic drugs and psychiatric disorders: mechanism involved in manifestation of psychic symptoms of high blood level of antiepileptics.
    Folia psychiatrica et neurologica japonica, 1983, Volume: 37, Issue:3

    Topics: Adult; Anticonvulsants; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Humans; Male; Mental D

1983
Effect of anticonvulsant drugs on thalamo-cortical and hippocampo-cortical self-sustained after-discharges in the rat.
    Physiologia Bohemoslovaca, 1984, Volume: 33, Issue:2

    Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Electric Stimulation; Electroencephalograp

1984
Summing up of the success so far gained through choice of drugs or combinations of drugs.
    Acta neurologica Scandinavica. Supplementum, 1984, Volume: 99

    Topics: Adult; Anticonvulsants; Carbamazepine; Cognition Disorders; Drug Therapy, Combination; Epilepsy; Hum

1984
Effect of valproate on free plasma phenytoin concentrations.
    British journal of clinical pharmacology, 1984, Volume: 18, Issue:1

    Topics: Adult; Binding, Competitive; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Protein Binding

1984
[The incidence of postoperative epilepsy and prophylactic anticonvulsants in patients with intracranial aneurysm].
    No shinkei geka. Neurological surgery, 1984, Volume: 12, Issue:3 Suppl

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; In

1984
Clinical value of determination of serum concentration of antiepileptics.
    Chinese medical journal, 1984, Volume: 97, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; In

1984
Nonsedative regimens in the treatment of epilepsy.
    Archives of internal medicine, 1983, Volume: 143, Issue:5

    Topics: Carbamazepine; Epilepsy; Ethosuximide; Humans; Phenytoin; Seizures; Valproic Acid

1983
A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients.
    British journal of clinical pharmacology, 1984, Volume: 18, Issue:3

    Topics: Anticonvulsants; Antipyrine; Carbamazepine; Enzyme Induction; Epilepsy; Female; Glucaric Acid; Half-

1984
[Plasma levels of antiepileptic agents in the treatment of epilepsy].
    Arquivos de neuro-psiquiatria, 1984, Volume: 42, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Interac

1984
Electrically elicited seizures from the inferior colliculus: a potential site for the genesis of epilepsy?
    Experimental neurology, 1984, Volume: 86, Issue:3

    Topics: Animals; Chlordiazepoxide; Electric Stimulation; Electrophysiology; Epilepsy; Inferior Colliculi; Ma

1984
Anticonvulsant effects on the memory performance of epileptics.
    Clinical and experimental neurology, 1984, Volume: 20

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Intelligence; Memory; Memory Di

1984
Anticonvulsants, folic acid and memory dysfunction in epileptics.
    Clinical and experimental neurology, 1984, Volume: 20

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Erythrocytes; Folic Acid; Humans; Memor

1984
[Mono- or polytherapy of epilepsy?].
    Wiener klinische Wochenschrift, 1984, Aug-03, Volume: 96, Issue:15

    Topics: Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Long-Term Care; Phenytoin

1984
Epilepsy in children.
    Family practice, 1984, Volume: 1, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diagnosis, Differential; Electroencephalogr

1984
Fetal exposure to anticonvulsant drugs. Detailed pathological study of a case.
    Archives of pathology & laboratory medicine, 1980, Volume: 104, Issue:4

    Topics: Abnormalities, Drug-Induced; Acetazolamide; Adult; Anticonvulsants; Brain; Cardiomegaly; Epilepsy; E

1980
Systemic effects of oral use of chlorhexidine gel in multihandicapped epileptic children.
    Scandinavian journal of dental research, 1981, Volume: 89, Issue:3

    Topics: Adolescent; Adult; Child; Child, Preschool; Chlorhexidine; Dental Care for Disabled; Double-Blind Me

1981
Clinical application of the Mullen and Foster method for individualizing phenytoin dosage.
    Italian journal of neurological sciences, 1984, Volume: 5, Issue:2

    Topics: Aged; Epilepsy; Female; Humans; Kinetics; Male; Middle Aged; Phenytoin

1984
Maprotiline hydrochloride associated with a clinical state of catatonic stupor and epileptic encephalogram.
    Journal of clinical psychopharmacology, 1984, Volume: 4, Issue:4

    Topics: Anthracenes; Catatonia; Depressive Disorder; Diazepam; Drug Therapy, Combination; Electroencephalogr

1984
Medically resistant epilepsy: low levels of drugs in the brain or pharmacological inefficacy?
    Acta neurologica, 1984, Volume: 6, Issue:3

    Topics: Adolescent; Adult; Brain; Drug Resistance; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin

1984
Bioavailability and pharmacokinetics of phenytoin during pregnancy.
    European journal of clinical pharmacology, 1984, Volume: 27, Issue:1

    Topics: Aging; Biological Availability; Epilepsy; Female; Humans; Kinetics; Phenytoin; Pregnancy; Pregnancy

1984
Functional palatal incompetence in the fetal anticonvulsant syndrome.
    Archives of disease in childhood, 1984, Volume: 59, Issue:10

    Topics: Abnormalities, Drug-Induced; Child, Preschool; Epilepsy; Female; Humans; Male; Maternal-Fetal Exchan

1984
Acquired craniofacial features associated with chronic phenytoin therapy.
    Clinical pediatrics, 1984, Volume: 23, Issue:12

    Topics: Adult; Chronic Disease; Epilepsy; Face; Female; Humans; Male; Maxillofacial Development; Phenytoin;

1984
Excretion of organic acids associated with biotin deficiency in chronic anticonvulsant therapy.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1984, Volume: 54, Issue:2-3

    Topics: Adult; Anticonvulsants; Biotin; Carbamazepine; Carboxy-Lyases; Carboxylic Acids; Epilepsy; Female; H

1984
Determination of plasma phenytoin by capillary gas chromatography with nitrogen-phosphorus detection and with selective ion monitoring.
    Journal of chromatography, 1984, Sep-14, Volume: 310, Issue:1

    Topics: Adult; Alkylation; Chemical Phenomena; Chemistry; Chromatography, Gas; Epilepsy; Female; Gas Chromat

1984
Changes induced in human liver by long-term anticonvulsant therapy. Functional and ultrastructural data.
    Liver, 1984, Volume: 4, Issue:5

    Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Endoplasm

1984
Bribery.
    Pathology annual, 1984, Volume: 19 Pt 2

    Topics: Adolescent; Epilepsy; Family Health; Gingival Hypertrophy; Humans; Lymph Nodes; Lymphatic Diseases;

1984
Teratogenicity of anticonvulsant drugs. III: Radiographic hand analysis of children exposed in utero to diphenylhydantoin.
    American journal of medical genetics, 1984, Volume: 19, Issue:3

    Topics: Epilepsy; Female; Hand; Hand Deformities, Congenital; Humans; Male; Phenytoin; Pregnancy; Pregnancy

1984
Genetic background: the elusive component in the fetal hydantoin syndrome.
    American journal of medical genetics, 1984, Volume: 19, Issue:3

    Topics: Epilepsy; Female; Hand Deformities, Congenital; Head; Humans; Phenytoin; Pregnancy; Pregnancy Compli

1984
[Epilepsy, anticonvulsants and pregnancy].
    Ginecologia y obstetricia de Mexico, 1984, Volume: 52, Issue:329

    Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications

1984
Differential effect of antiepileptic and non-antiepileptic drugs on the reticular formation.
    Life sciences, 1984, Dec-24, Volume: 35, Issue:26

    Topics: Action Potentials; Animals; Anticonvulsants; Baclofen; Carbamazepine; Cats; Dose-Response Relationsh

1984
Effect of folic acid supplementation on congenital malformations due to anticonvulsive drugs.
    European journal of obstetrics, gynecology, and reproductive biology, 1984, Volume: 18, Issue:4

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Folic Aci

1984
Single dose pharmacokinetic study of clobazam in normal volunteers and epileptic patients.
    British journal of clinical pharmacology, 1984, Volume: 18, Issue:6

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbama

1984
High-dose monotherapy in treatment of intractable seizures.
    Neurology, 1984, Volume: 34, Issue:6

    Topics: Adult; Carbamazepine; Epilepsy; Humans; Middle Aged; Phenytoin; Seizures

1984
Therapeutic plasma levels of phenytoin, phenobarbital, and carbamazepine: individual variation in relation to seizure frequency and type.
    Neurology, 1984, Volume: 34, Issue:9

    Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenobar

1984
Chromosomal studies of peripheral blood from epileptic patients treated with phenobarbital and/or diphenylhydantoin.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1984, Volume: 22, Issue:12

    Topics: Adult; Animals; Chromosome Aberrations; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; M

1984
The estimation of working capacity in epileptic patients.
    Acta neurologica Scandinavica. Supplementum, 1983, Volume: 93

    Topics: Adolescent; Adult; Disability Evaluation; Epilepsy; Finland; Humans; Phenytoin; Prognosis; Rehabilit

1983
Case of the month. Gingival enlargement.
    Journal of the Indian Dental Association, 1983, Volume: 55, Issue:8

    Topics: Adolescent; Epilepsy; Gingival Hypertrophy; Humans; Male; Phenytoin

1983
Medical exorcism--acute dilantin intoxication.
    North Carolina medical journal, 1984, Volume: 45, Issue:2

    Topics: Cardiovascular Diseases; Epilepsy; Humans; Kinetics; Nystagmus, Pathologic; Phenytoin

1984
Phenytoin induced gingival overgrowth in institutionalized epileptics.
    Journal of clinical periodontology, 1984, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Aged; Epilepsy; Female; Gingival Hyperplasia; Gingivitis; Humans; Institutionaliz

1984
Rationalisation of therapy in severe epilepsy.
    Australian and New Zealand journal of medicine, 1983, Volume: 13, Issue:6

    Topics: Adult; Anticonvulsants; Arousal; Atrophy; Cerebellum; Drug Administration Schedule; Drug Therapy, Co

1983
Oral hygiene status of epileptic patients under treatment with diphenyl hydantoin.
    Odonto-stomatologie tropicale = Tropical dental journal, 1983, Volume: 6, Issue:4

    Topics: Adolescent; Adult; Aged; Child; Epilepsy; Female; Gingival Hyperplasia; Humans; Male; Middle Aged; P

1983
The influence of carbamazepine and phenytoin on memory and other aspects of cognitive function in new referrals with epilepsy.
    Acta neurologica Scandinavica. Supplementum, 1984, Volume: 99

    Topics: Adolescent; Adult; Aged; Carbamazepine; Cognition Disorders; Decision Making; Epilepsy; Fixation, Oc

1984
Dementia in epilepsy.
    Acta neurologica Scandinavica. Supplementum, 1984, Volume: 99

    Topics: Adult; Anticonvulsants; Brain Injuries; Dementia; Epilepsy; Epilepsy, Temporal Lobe; Humans; Middle

1984
Regression of gingival hyperplasia after cessation of phenytoin drug therapy--a case report.
    Quintessence international, dental digest, 1984, Volume: 15, Issue:5

    Topics: Adult; Epilepsy; Gingival Hyperplasia; Humans; Male; Phenytoin; Remission, Spontaneous

1984
Effects of phenobarbital, diphenylhydantoin and carbamazepine on thyroid function in epileptic children.
    Acta endocrinologica. Supplementum, 1984, Volume: 265

    Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Epilepsy; Humans; Phenobarbital; Phenytoin; Thyr

1984
Effects of phenytoin on man's immunity. Evaluation of changes in serum immunoglobulins, complement, and antinuclear antibody.
    The American journal of medicine, 1983, Volume: 74, Issue:2

    Topics: Adolescent; Adult; Aged; Antibodies, Antinuclear; Central Nervous System Diseases; Child; Child, Pre

1983
Brain regional pharmacokinetics of 11C-labeled diphenylhydantoin: positron emission tomography in humans.
    Neurology, 1983, Volume: 33, Issue:5

    Topics: Adolescent; Adult; Brain; Carbon Radioisotopes; Epilepsy; Female; Humans; Kinetics; Male; Phenytoin;

1983
The effect of prolonged phenytoin administration on non-collagenous components of gingival tissue.
    International journal of tissue reactions, 1983, Volume: 5, Issue:2

    Topics: Adult; Epilepsy; Gingiva; Hexosamines; Humans; Hyperplasia; Middle Aged; Phenytoin; Proteins; Uronic

1983
Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports.
    Italian journal of neurological sciences, 1983, Volume: 4, Issue:2

    Topics: Adult; Drug Therapy, Combination; Epilepsy; Gynecomastia; Humans; Male; Phenobarbital; Phenytoin; Pr

1983
Routine determination of hydroxyphenytoin in urine by high-performance liquid chromatography using an automatic column-switching technique.
    Journal of chromatography, 1983, Jul-08, Volume: 275, Issue:2

    Topics: Chromatography, High Pressure Liquid; Epilepsy; Humans; Phenytoin; Statistics as Topic

1983
Acute effects of intravenous phenytoin on the frequency of inter-ictal spikes in man.
    British journal of clinical pharmacology, 1983, Volume: 16, Issue:3

    Topics: Adult; Electroencephalography; Epilepsy; Humans; Infusions, Parenteral; Phenytoin; Time Factors

1983
Oxazepam pharmacokinetics in patients with epilepsy treated long-term with phenytoin alone or in combination with phenobarbitone.
    British journal of clinical pharmacology, 1983, Volume: 16, Issue:4

    Topics: Adult; Bilirubin; Dialysis; Drug Interactions; Epilepsy; Female; Humans; Kinetics; Male; Middle Aged

1983
[Development of malignant lymphoma during anticonvulsant therapy].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1983, Apr-18, Volume: 38, Issue:16

    Topics: Epilepsy; Gastrointestinal Neoplasms; Humans; Lung Neoplasms; Lymphoma; Male; Middle Aged; Phenytoin

1983
[Phenytoin kinetics in toxic serum levels].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1983, Volume: 35, Issue:8

    Topics: Adolescent; Adult; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Kinetics; Male

1983
Gas-liquid chromatographic determination of propylene glycol in plasma and urine.
    Clinical chemistry, 1983, Volume: 29, Issue:12

    Topics: Butylene Glycols; Chromatography, Gas; Epilepsy; Flame Ionization; Humans; Phenytoin; Propylene Glyc

1983
[Relations to the use of antiepileptics by the pregnant woman to the development of congenital abnormalities in her child].
    Nederlands tijdschrift voor geneeskunde, 1983, Oct-29, Volume: 127, Issue:44

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Hydantoins; Infant, Newborn;

1983
[Hydantoin poisoning: clinical aspects, laboratory parameters and EEG].
    Der Nervenarzt, 1983, Volume: 54, Issue:10

    Topics: Adolescent; Adult; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Therapy, Combinat

1983
A quantitative determination of anticonvulsant-induced bone demineralization by an improved X-ray densitometry technique.
    Neuroradiology, 1983, Volume: 25, Issue:5

    Topics: Absorptiometry, Photon; Adolescent; Adult; Aged; Anticonvulsants; Bone and Bones; Carbamazepine; Dru

1983
Reduction of polypharmacy for epilepsy in an institution for the retarded.
    Developmental medicine and child neurology, 1983, Volume: 25, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Huma

1983
Salivary phenytoin levels in institutionalized epileptics.
    Journal of chronic diseases, 1983, Volume: 36, Issue:12

    Topics: Adolescent; Adult; Aged; Chromatography, Gas; Epilepsy; Humans; Institutionalization; Intellectual D

1983
Presenile cataracts in hydantoin-treated epileptic patients.
    Metabolic, pediatric, and systemic ophthalmology, 1983, Volume: 7, Issue:3

    Topics: Adult; Animals; Cataract; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Rats

1983
Phenytoin and folic acid: individualized drug-drug interaction.
    Therapeutic drug monitoring, 1983, Volume: 5, Issue:4

    Topics: Drug Interactions; Epilepsy; Folic Acid; Humans; Male; Middle Aged; Phenytoin

1983
Predicting phenytoin dosages using Bayesian feedback: a comparison with other methods.
    Therapeutic drug monitoring, 1983, Volume: 5, Issue:4

    Topics: Adult; Bayes Theorem; Epilepsy; Female; Humans; Kinetics; Male; Middle Aged; Models, Biological; Phe

1983
Fluctuations in steady-state phenytoin concentrations as measured in saliva in children.
    Pediatric pharmacology (New York, N.Y.), 1983, Volume: 3, Issue:2

    Topics: Capsules; Child; Child, Preschool; Epilepsy; Female; Humans; Kinetics; Male; Phenytoin; Saliva; Susp

1983
A design for the prospective evaluation of the efficacy and toxicity of antiepileptic drugs in adults.
    Neurology, 1983, Volume: 33, Issue:3 Suppl 1

    Topics: Adult; Aged; Anticonvulsants; Behavior; Carbamazepine; Clinical Trials as Topic; Double-Blind Method

1983
Comparison of bioavailability for phenytoin products prepared by wet granulation in normal subjects and epileptic patients.
    Journal of pharmacobio-dynamics, 1983, Volume: 6, Issue:10

    Topics: Adolescent; Adult; Biological Availability; Child; Child, Preschool; Epilepsy; Feces; Female; Humans

1983
Effect of phenytoin and corticosteroids on seizures and lipid peroxidation in experimental posttraumatic epilepsy.
    Journal of neurosurgery, 1984, Volume: 60, Issue:3

    Topics: Animals; Brain Injuries; Chlorides; Electroencephalography; Epilepsy; Ferric Compounds; Lipid Peroxi

1984
Variability of phenytoin protein binding in epilepsy.
    Archives of neurology, 1984, Volume: 41, Issue:4

    Topics: Epilepsy; Humans; Phenytoin

1984
Influence of bioavailability on the calculated Michaelis-Menten parameters of phenytoin in children.
    Therapeutic drug monitoring, 1984, Volume: 6, Issue:1

    Topics: Absorption; Adolescent; Biological Availability; Child; Child, Preschool; Dose-Response Relationship

1984
Phenytoin preferentially suppresses epileptiform activity in the superficial cortical layers of the cat.
    Brain research, 1984, Mar-19, Volume: 295, Issue:2

    Topics: Animals; Cats; Cerebral Cortex; Electroencephalography; Epilepsy; Penicillins; Phenytoin

1984
Serum concentrations and efficacy of phenytoin, phenobarbital, and primidone in canine epilepsy.
    Journal of the American Veterinary Medical Association, 1984, May-01, Volume: 184, Issue:9

    Topics: Animals; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Phenobarbital; Phenytoin; Primidon

1984
[Initial therapeutic results in epileptic children with and without serum-controlled phenytoin treatment].
    Padiatrie und Grenzgebiete, 1984, Volume: 23, Issue:1

    Topics: Child; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Humans; Phenytoin; Progno

1984
[EEG findings and phenytoin concentration in the serum of children with epilepsy].
    Padiatrie und Grenzgebiete, 1984, Volume: 23, Issue:2

    Topics: Child; Electroencephalography; Epilepsy; Female; Humans; Male; Phenytoin

1984
Plasma concentrations of unbound phenytoin in the management of epilepsy.
    British journal of clinical pharmacology, 1984, Volume: 17, Issue:5

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbon Radioisotopes; Child; Drug Therapy, Combination; Ep

1984
Cerebellar atrophy following diphenylhydantoin intoxication.
    Neuropediatrics, 1984, Volume: 15, Issue:2

    Topics: Adolescent; Atrophy; Cerebellum; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Ph

1984
Kinetics of intravenous phenytoin in children.
    Pediatric pharmacology (New York, N.Y.), 1984, Volume: 4, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Infant; Injections, Intravenous; Kinetics; Ph

1984
Urinary hydroxyphenytoin/creatinine ratios as an index of compliance in adult epileptic patients on phenytoin therapy.
    Therapeutic drug monitoring, 1984, Volume: 6, Issue:2

    Topics: Creatinine; Epilepsy; Female; Humans; Male; Models, Biological; Patient Compliance; Phenytoin

1984
Use of plasma unbound drug concentrations in adjusting phenytoin doses.
    Therapeutic drug monitoring, 1984, Volume: 6, Issue:2

    Topics: Adolescent; Adult; Blood Proteins; Child; Child, Preschool; Epilepsy; Female; Humans; Kinetics; Male

1984
Prospective neurometric studies during the beginning of carbamazepine and phenytoin therapy.
    Acta neurologica Scandinavica, 1984, Volume: 69, Issue:4

    Topics: Action Potentials; Adolescent; Adult; Carbamazepine; Cerebral Cortex; Electroencephalography; Electr

1984
Antiepileptic drug utilization in pediatric patients.
    Epilepsia, 1984, Volume: 25 Suppl 2

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Infant; Infant, Newborn; Kin

1984
[Anticonvulsive combined therapy (author's transl)].
    Wiener klinische Wochenschrift, 1980, Jan-04, Volume: 92, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epileps

1980
Sex hormone changes in male epileptics.
    Clinical endocrinology, 1980, Volume: 12, Issue:4

    Topics: Adult; Epilepsy; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Humans; Luteinizing Hormone

1980
[Differential treatment of epilepsy patients].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1980, Volume: 80, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Diagnosis, Differential; Drug Therapy, Combination; Epilepsy; Epilep

1980
Variable in vivo binding of valproic acid in epilepsy patients being medicated with other anticonvulsants.
    Clinical chemistry, 1980, Volume: 26, Issue:11

    Topics: Binding, Competitive; Epilepsy; Humans; Phenytoin; Serum Albumin; Valproic Acid

1980
Therapeutic alternatives in phenytoin-induced gingival hyperplasia. A case report and discussion.
    Journal of periodontology, 1980, Volume: 51, Issue:9

    Topics: Adolescent; Epilepsy; Female; Gingival Hyperplasia; Humans; Phenytoin; Primidone; Valproic Acid

1980
Binding of drugs to human serum albumin. XIV. The theoretical basis for the interaction between phenytoin and valproate.
    Molecular pharmacology, 1980, Volume: 18, Issue:2

    Topics: Adolescent; Binding, Competitive; Blood Proteins; Child; Epilepsy; Humans; Phenytoin; Protein Bindin

1980
Interaction between phenytoin and valproate.
    The Medical journal of Australia, 1980, Aug-23, Volume: 2, Issue:4

    Topics: Blood Proteins; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Protein B

1980
Pharmacokinetics of anticonvulsant drugs.
    Acta neurologica Scandinavica. Supplementum, 1980, Volume: 80

    Topics: Anticonvulsants; Binding, Competitive; Brain; Carbamazepine; Drug Interactions; Drug Tolerance; Epil

1980
Drug interactions in epilepsy.
    Arquivos de neuro-psiquiatria, 1980, Volume: 38, Issue:4

    Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Humans; Isoniazid; P

1980
Impact of therapeutic audit on phenytoin prescribing.
    British medical journal (Clinical research ed.), 1981, Apr-18, Volume: 282, Issue:6272

    Topics: Drug Administration Schedule; Epilepsy; Humans; Medical Audit; Phenytoin

1981
Cimetidine interaction with phenytoin.
    British medical journal (Clinical research ed.), 1981, May-09, Volume: 282, Issue:6275

    Topics: Adult; Cimetidine; Drug Interactions; Epilepsy; Guanidines; Humans; Middle Aged; Phenytoin

1981
Drug treatment of epilepsy.
    Comprehensive therapy, 1981, Volume: 7, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Female;

1981
[Daily fluctuations of plasma diphenylhydantoin in patients treated with diphenylhydantoin and sodium valproate].
    Acta neurologica, 1981, Volume: 3, Issue:1

    Topics: Adult; Circadian Rhythm; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Valproic Acid

1981
[Daily plasma fluctuations of diphenylhydantoin in patients treated with diphenylhydantoin and sodium valproate].
    Acta neurologica. Quaderni, 1981, Volume: 42

    Topics: Adult; Epilepsy; Humans; Phenytoin; Time Factors; Valproic Acid

1981
[Polytherapy and monotherapy in the treatment of patients with epilepsy].
    Acta neurologica. Quaderni, 1981, Volume: 42

    Topics: Adult; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy,

1981
Recent advances in the treatment of epilepsy.
    Acta neurologica Scandinavica. Supplementum, 1980, Volume: 78

    Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Huma

1980
[Spindles and spike waves in the sleep EEG of epileptic patients under administration of phenobarbital (PB) and phenytoin (DPH) (author's transl)].
    EEG-EMG Zeitschrift fur Elektroenzephalographie, Elektromyographie und verwandte Gebiete, 1981, Volume: 12, Issue:3

    Topics: Electroencephalography; Epilepsy; Evoked Potentials; Humans; Phenobarbital; Phenytoin; Sleep Stages

1981
[EEG in phenytoin intoxication (author's transl)].
    EEG-EMG Zeitschrift fur Elektroenzephalographie, Elektromyographie und verwandte Gebiete, 1981, Volume: 12, Issue:3

    Topics: Adult; Central Nervous System Diseases; Cerebellar Ataxia; Dose-Response Relationship, Drug; Electro

1981
Phenytoin-valproate interaction: importance of saliva monitoring in epilepsy.
    British medical journal (Clinical research ed.), 1982, Jan-02, Volume: 284, Issue:6308

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Epil

1982
Daily fluctuations of dipropylacetate (DPA) serum level in epileptic patients.
    Monographs in neural sciences, 1980, Volume: 5

    Topics: Adolescent; Adult; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle

1980
Serial free and plasma valproic acid and phenytoin monitoring and drug interactions.
    Therapeutic drug monitoring, 1981, Volume: 3, Issue:3

    Topics: Adolescent; Adult; Circadian Rhythm; Drug Interactions; Epilepsy; Female; Humans; Male; Phenytoin; V

1981
Plasma levels and pharmacokinetics of antipileptic drugs in children.
    Folia psychiatrica et neurologica japonica, 1981, Volume: 35, Issue:3

    Topics: Adolescent; Age Factors; Anticonvulsants; Biological Availability; Biotransformation; Carbamazepine;

1981
Epileptic seizures in the elderly: II. Diagnostic problems.
    Age and ageing, 1982, Volume: 11, Issue:1

    Topics: Aged; Brain; Cerebral Infarction; Confusion; Dementia; Diagnosis, Differential; Electroencephalograp

1982
Diurnal oscillations in plasma protein binding of valproic acid.
    Epilepsia, 1982, Volume: 23, Issue:3

    Topics: Adolescent; Adult; Blood Proteins; Circadian Rhythm; Epilepsy; Fatty Acids, Nonesterified; Female; H

1982
Stuporous episodes during treatment with sodium valproate: report of seven cases.
    Epilepsia, 1982, Volume: 23, Issue:3

    Topics: Anticonvulsants; Cognition Disorders; Consciousness Disorders; Electroencephalography; Epilepsy; Fem

1982
Monitoring free valproic acid in epilepsy patients medicated with coanticonvulsants.
    Therapeutic drug monitoring, 1982, Volume: 4, Issue:2

    Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Phenytoin; Valpro

1982
The effects of anticonvulsants on memory function in epileptic patients: preliminary findings.
    Clinical and experimental neurology, 1981, Volume: 17

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Memory; Memory, Short-Term; Mental Recall; Phenyto

1981
Phenytoin elimination after intoxication during long-term treatment.
    The Medical journal of Australia, 1982, Sep-04, Volume: 2, Issue:5

    Topics: Adolescent; Adult; Epilepsy; Female; Humans; Long-Term Care; Middle Aged; Phenytoin

1982
Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy.
    Obstetrics and gynecology, 1982, Volume: 60, Issue:5

    Topics: Adult; Anticonvulsants; Antipyrine; Delivery, Obstetric; Dose-Response Relationship, Drug; Epilepsy;

1982
Early prognosis of epilepsy.
    British medical journal (Clinical research ed.), 1982, Dec-11, Volume: 285, Issue:6356

    Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsies, Partial; Epilepsy; Female; Humans; Male;

1982
Therapeutic concentration of antiepileptic drugs and the severity of epileptogenesis.
    Electroencephalography and clinical neurophysiology. Supplement, 1982, Volume: 36

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Isoxazoles; Phenytoin; Valproic Acid; Zonisamide

1982
[A study on cerebrospinal fluid and saliva to serum concentration ratios of anticonvulsants--Phenytoin, Phenobarbital, Valproic Acid and Primidone in epileptic patients].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1982, Volume: 84, Issue:9

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Middle Aged; Phenobar

1982
[Studies on the mechanism of metabolic acidosis observed in the children treated with anticonvulsants].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1982, Volume: 57, Issue:6

    Topics: Acidosis; Adolescent; Binding Sites; Calcium; Carbonic Anhydrases; Child; Child, Preschool; Drug The

1982
[Mono- or polytherapy in the treatment of epileptic patients].
    Minerva medica, 1983, Jan-14, Volume: 74, Issue:1-2

    Topics: Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phen

1983
Presenile cataracts in phenytoin-treated epileptic patients.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1983, Volume: 101, Issue:3

    Topics: Adult; Aging; Animals; Cataract; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Rodentia

1983
Motor and sensory conduction velocities and electromyographic findings in man before and after carbamazepine treatment.
    Acta neurologica Scandinavica, 1983, Volume: 67, Issue:2

    Topics: Carbamazepine; Electromyography; Epilepsy; Humans; Neural Conduction; Peripheral Nerves; Phenytoin

1983
Serum concentration of clonazepam and the therapeutic effect of the drug.
    Acta neurologica Scandinavica, 1983, Volume: 67, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepinones; Clonazepam; Epilepsy; Female; Humans; Male; M

1983
Hypermetabolism of phenytoin as a cause of treatment failure.
    Clinical neuropharmacology, 1983, Volume: 6, Issue:1

    Topics: Adult; Drug Resistance; Epilepsy; Humans; Kinetics; Male; Phenytoin

1983
Effect of cimetidine on phenytoin serum levels.
    Epilepsia, 1983, Volume: 24, Issue:3

    Topics: Cimetidine; Drug Synergism; Epilepsy; Guanidines; Humans; Male; Phenytoin

1983
Falsely localizing ictal onsets with depth EEG telemetry during anticonvulsant withdrawal.
    Epilepsia, 1983, Volume: 24, Issue:3

    Topics: Adult; Electroencephalography; Epilepsy; Humans; Male; Meningeal Neoplasms; Meningioma; Phenytoin; S

1983
The influence of bilirubin, alcohol and certain drugs on the kinetics of 99mTc-Diethyl IDA (EHIDA) in humans.
    European journal of nuclear medicine, 1983, Volume: 8, Issue:4

    Topics: Alcoholism; Bilirubin; Epilepsy; Ethanol; Humans; Imino Acids; Jaundice; Kinetics; Phenobarbital; Ph

1983
[Monitoring of plasma diphenylhydantoin levels in epileptic patients].
    Boletin medico del Hospital Infantil de Mexico, 1983, Volume: 40, Issue:5

    Topics: Adolescent; Adult; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infant

1983
High-performance liquid chromatographic determination of phenytoin and hydroxyphenytoin in human urine.
    Journal of chromatography, 1983, Jun-10, Volume: 275, Issue:1

    Topics: Adult; Aged; Chromatography, High Pressure Liquid; Epilepsy; Female; Humans; Male; Middle Aged; Phen

1983
[Radioimmunologic study of the plasma concentrations of folic acid and various antiepileptic preparations during the treatment of epileptic patients].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1983, Volume: 83, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Benzamidines; Drug Therapy, Combination; Epilepsy; Female; Folic

1983
Phenytoin in pregnancy: a review of the reported risks.
    Biological research in pregnancy and perinatology, 1983, Volume: 4, Issue:2

    Topics: Abnormalities, Drug-Induced; Blood Coagulation Disorders; Epilepsy; Female; Humans; Infant; Infant,

1983
Epileptic seizures controlled with paramethadione/primidone.
    Veterinary medicine, small animal clinician : VM, SAC, 1981, Volume: 76, Issue:6

    Topics: Animals; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Male; Oxazoles; Phenytoin; Primido

1981
A study of the action of anticonvulsant drugs on an experimental model of epilepsy.
    Acta physiologica latino americana, 1980, Volume: 30, Issue:4

    Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Electric Stimulation; Epi

1980
Dental root abnormalities and gingival overgrowth in epileptic patients receiving anticonvulsant therapy.
    Journal of periodontology, 1980, Volume: 51, Issue:8

    Topics: Adolescent; Adult; Child; Epilepsy; Female; Gingival Hyperplasia; Humans; Intellectual Disability; M

1980
Anticonvulsants and mental symptoms.
    Acta neurologica Scandinavica. Supplementum, 1980, Volume: 80

    Topics: Anticonvulsants; Barbiturates; Biogenic Amines; Epilepsy; Folic Acid Deficiency; Hormones; Humans; M

1980
Anticonvulsant drugs, cognitive function and memory.
    Acta neurologica Scandinavica. Supplementum, 1980, Volume: 80

    Topics: Anticonvulsants; Carbamazepine; Double-Blind Method; Epilepsy; Humans; Male; Memory Disorders; Menta

1980
Prescribing patterns for epilepsy.
    The New Zealand medical journal, 1981, Jul-08, Volume: 93, Issue:687

    Topics: Adult; Anticonvulsants; Child; Drug Prescriptions; Drug Therapy, Combination; Drug Utilization; Epil

1981
Elementary pharmacokinetics in clinical practice. 3: Practical pharmacokinetic applications.
    The New Zealand medical journal, 1981, Nov-25, Volume: 94, Issue:696

    Topics: Administration, Oral; Biopharmaceutics; Dose-Response Relationship, Drug; Epilepsy; Humans; Injectio

1981
Carbamazepine. Pharmacology and clinical uses.
    Acta neurologica Scandinavica. Supplementum, 1981, Volume: 88

    Topics: Adult; Alcohol Withdrawal Delirium; Arrhythmias, Cardiac; Behavior; Carbamazepine; Child; Diabetes I

1981
[Gingival fibromatosis associated with bilateral palatal fibromas].
    Acta stomatologica Belgica, 1982, Volume: 79, Issue:1

    Topics: Adult; Epilepsy; Female; Fibroma; Gingival Hyperplasia; Humans; Palatal Neoplasms; Phenytoin

1982
[Combined surgical and prosthetic rehabilitation of epileptics].
    Fogorvosi szemle, 1982, Volume: 75, Issue:5

    Topics: Denture, Complete; Epilepsy; Gingival Hyperplasia; Gingivectomy; Gingivoplasty; Humans; Phenytoin; T

1982
Binge eating - therapeutic response to diphenylhydantoin: case report.
    The Journal of clinical psychiatry, 1982, Volume: 43, Issue:9

    Topics: Adult; Electroencephalography; Epilepsy; Feeding and Eating Disorders; Female; Humans; Hyperphagia;

1982
Effect of 5,5-diphenylhydantoin on a gingival hyperplasia development.
    Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove, 1980, Volume: 23, Issue:5

    Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Gingiva; Gingival Hyperplasia; Humans;

1980
Phenytoin intoxication and cotrimoxazole.
    The New Zealand medical journal, 1981, Sep-23, Volume: 94, Issue:692

    Topics: Adult; Drug Combinations; Drug Interactions; Epilepsy; Humans; Male; Phenytoin; Sulfamethoxazole; Tr

1981
Some immunological reactions during chronic treatment with antiepileptic drugs.
    Italian journal of neurological sciences, 1981, Volume: 2, Issue:1

    Topics: Adult; Antibody Formation; B-Lymphocytes; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy;

1981
Lymphocyte subpopulations and lymphocyte function in phenytoin-treated patients with epilepsy.
    International journal of immunopharmacology, 1982, Volume: 4, Issue:1

    Topics: Adolescent; Adult; Aged; Dysgammaglobulinemia; Epilepsy; Female; Humans; IgA Deficiency; Leukocytes;

1982
Serum vitamin D metabolites in epileptic patients treated with 2 different anti-convulsants.
    Acta neurologica Scandinavica, 1982, Volume: 66, Issue:3

    Topics: 24,25-Dihydroxyvitamin D 3; Adult; Aged; Alkaline Phosphatase; Calcifediol; Calcitriol; Calcium; Car

1982
Effect of single doses of sodium valproate on serum phenytoin levels and protein binding in epileptic patients.
    Clinical pharmacology and therapeutics, 1980, Volume: 27, Issue:1

    Topics: Adult; Blood Proteins; Epilepsy; Humans; Kinetics; Male; Phenytoin; Protein Binding; Valproic Acid

1980
Epilepsy and the oral manifestations of phenytoin therapy.
    Monographs in oral science, 1981, Volume: 9

    Topics: Animals; Anticonvulsants; Epilepsy; Gingival Hypertrophy; History, Ancient; History, Medieval; Histo

1981
[The determination of anticonvulsant drug levels in blood by enzyme immunoassay: method and clinical application (author's transl)].
    Rinsho byori. The Japanese journal of clinical pathology, 1980, Volume: 28, Issue:10

    Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Immunoenzyme Techniques; Male; P

1980
Antibodies to Escherichia coli and serum immunoglobulin levels in epileptics on long-term anticonvulsant therapy.
    Clinical and experimental immunology, 1981, Volume: 45, Issue:1

    Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Antibodies, Bacterial; Epilepsy; Esch

1981
Stability of antiepileptic drug level in serum. Reliability of enzyme immunoassay method.
    Monographs in neural sciences, 1980, Volume: 5

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Immunoenzyme Techniques; Phenobarbital; Phe

1980
[Therapy control by determination of serum drug concentrations].
    Der Internist, 1982, Volume: 23, Issue:3

    Topics: Asthma; Drug Therapy; Epilepsy; Humans; Phenytoin; Quality Control; Reference Standards; Theophyllin

1982
Age and phenytoin kinetics in adult epileptics.
    Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:3

    Topics: Adult; Aged; Aging; Epilepsy; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged;

1982
Comparative study of bioavailabilities of different phenytoin preparations.
    Brain & development, 1982, Volume: 4, Issue:1

    Topics: Administration, Oral; Adolescent; Biological Availability; Child; Child, Preschool; Dose-Response Re

1982
[Reduction of biotin level as a possible factor in the mode of action of anticonvulsants (author's transl)].
    Archiv fur Psychiatrie und Nervenkrankheiten, 1982, Volume: 231, Issue:2

    Topics: Adult; Anticonvulsants; Biotin; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Female; Hu

1982
Drug interactions on an alcohol unit.
    Virginia medical, 1982, Volume: 109, Issue:4

    Topics: Adult; Alcoholism; Ataxia; Diagnosis, Differential; Drug Interactions; Epilepsy; Humans; Male; Oxaze

1982
Serum elevation of high density lipoprotein (HDL) cholesterol in epileptic patients taking carbamazepine or phenytoin.
    Acta neurologica Scandinavica, 1982, Volume: 65, Issue:2

    Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Cholesterol; Cholesterol, HDL; Epilepsy;

1982
Combined fetal alcohol and hydantoin syndromes.
    Clinical pediatrics, 1982, Volume: 21, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Alcoholism; Epilepsy; Female; Fetal Alc

1982
[Humoral and cell-mediated immunities in epileptic patients (author's transl)].
    Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology, 1982, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Antibody Formation; Complement System Proteins; Epilepsy; Female; Humans; Immunit

1982
Quality of care of epilepsy in Italy: multi-hospital survey of diagnosis and treatment of 1104 epileptic patients.
    Epilepsia, 1982, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Health Surveys;

1982
Comparative bioavailability of phenytoin from generic formulations in the United Kingdom.
    Epilepsia, 1982, Volume: 23, Issue:2

    Topics: Adult; Aged; Biological Availability; Dosage Forms; Epilepsy; Humans; Middle Aged; Phenytoin; Tablet

1982
Diphenylhydantoin excretion in the semen of treated epileptics.
    Israel journal of medical sciences, 1982, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Epilepsy; Humans; Male; Phenytoin; Semen

1982
Prediction of phenytoin dosage in epilepsy using multiple linear regression.
    Annals of clinical biochemistry, 1982, Volume: 19, Issue:3

    Topics: Body Weight; Dose-Response Relationship, Drug; Epilepsy; Humans; Phenytoin

1982
Cerebrospinal fluid and blood thiamine concentrations in phenytoin-treated epileptics.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1982, Volume: 9, Issue:1

    Topics: Epilepsy; Folic Acid; Humans; Middle Aged; Phenytoin; Thiamine

1982
Phenytoin influence on human lymphocyte mitogen response: a prospective study of epileptic and nonepileptic patients.
    Epilepsia, 1982, Volume: 23, Issue:4

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Concanavalin A; Epilepsy; Female; Humans; Immunogl

1982
Comparison of phenytoin and phenobarbital effects on far-field auditory and somatosensory evoked potential interpeak latencies.
    Epilepsia, 1982, Volume: 23, Issue:4

    Topics: Epilepsy; Evoked Potentials, Auditory; Evoked Potentials, Somatosensory; Humans; Phenobarbital; Phen

1982
Is there a climatic influence on the blood level of anticonvulsive drugs?
    Medical hypotheses, 1982, Volume: 8, Issue:4

    Topics: Climate; Epilepsy; Hot Temperature; Humans; Humidity; Phenytoin; Sweating

1982
[Phenytoin serum concentration in epileptic patients: influence of therapeutic and physiological factors (author's transl)].
    Der Nervenarzt, 1982, Volume: 53, Issue:5

    Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Fema

1982
Phenytoin: an inhibitor and inducer of primidone metabolism in an epileptic patient.
    British journal of clinical pharmacology, 1982, Volume: 14, Issue:2

    Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Phenobarbital; Phenylethylmalonamide; Phenytoin;

1982
Plasma protein binding of phenytoin in 100 epileptic patients.
    British journal of clinical pharmacology, 1982, Volume: 14, Issue:2

    Topics: Adolescent; Adult; Aged; Blood Proteins; Child; Child, Preschool; Drug Interactions; Epilepsy; Femal

1982
Therapeutic failures in epileptic children due to impaired diphenylhydantoin bioavailability.
    Israel journal of medical sciences, 1982, Volume: 18, Issue:6

    Topics: Biological Availability; Child; Epilepsy; Humans; Phenytoin

1982
Differences between the concentrations of antiepileptic drugs in normal and pathological human brain.
    European journal of clinical pharmacology, 1982, Volume: 22, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Brain; Carbamazepine; Child; Electroencephalography; Epilepsy; F

1982
Urine and plasma free phenytoin concentration correlation.
    Clinical pharmacology and therapeutics, 1982, Volume: 32, Issue:5

    Topics: Adolescent; Adult; Child; Chromatography, Gas; Epilepsy; Humans; Middle Aged; Phenytoin

1982
Hypertrophic retroauricular folds attributable to diphenylhydantoin therapy.
    Cutis, 1982, Volume: 30, Issue:2

    Topics: Adult; Ear, External; Epilepsy; Humans; Hypertrophy; Male; Phenytoin; Skin; Skin Diseases; Time Fact

1982
[Serum beta-glucuronidase activity in patients treated with phenobarbital and diphenylhydantoin].
    Archivos de farmacologia y toxicologia, 1982, Volume: 8, Issue:1

    Topics: Adult; Drug Therapy, Combination; Enzyme Induction; Epilepsy; Female; Glucuronidase; Humans; Liver;

1982
Zinc and copper metabolism in phenytoin therapy.
    Epilepsia, 1982, Volume: 23, Issue:5

    Topics: Adult; Aged; Anticonvulsants; Copper; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Mid

1982
[Diphenylhydantoin in the comprehensive treatment of epileptic attacks].
    Ceskoslovenska neurologie a neurochirurgie, 1982, Volume: 45, Issue:6

    Topics: Adolescent; Adult; Aged; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin

1982
HLA antigens in epileptic patients with drug-induced immunodeficiency.
    International journal of immunopharmacology, 1982, Volume: 4, Issue:6

    Topics: Adult; Anticonvulsants; Carbamazepine; Dysgammaglobulinemia; Epilepsy; Female; HLA Antigens; Humans;

1982
Rapid and slow release phenytoin in epileptic patients at steady state: comparative plasma levels and toxicity.
    Journal of pharmacokinetics and biopharmaceutics, 1982, Volume: 10, Issue:4

    Topics: Adolescent; Adult; Delayed-Action Preparations; Epilepsy; Female; Humans; Kinetics; Male; Middle Age

1982
Rapid and slow release phenytoin in epileptic patients at steady state: assessment of relative bioavailability utilizing Michaelis-Menten parameters.
    Journal of pharmacokinetics and biopharmaceutics, 1982, Volume: 10, Issue:4

    Topics: Biological Availability; Delayed-Action Preparations; Epilepsy; Humans; Kinetics; Phenytoin

1982
[Results of phenytoin monitoring in patients with epilepsy].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1982, Nov-22, Volume: 37, Issue:45

    Topics: Adult; Epilepsy; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Phenytoin

1982
Drug interactions during anticonvulsant medication.
    The Journal of the Association of Physicians of India, 1982, Volume: 30, Issue:8

    Topics: Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phen

1982
Immunoglobulins in epilepsy.
    Journal of the neurological sciences, 1982, Volume: 56, Issue:2-3

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Fe

1982
[Cytogenetic study of diphenylhydantoin therapy using SCE].
    Archivos de farmacologia y toxicologia, 1982, Volume: 8, Issue:3

    Topics: Adult; Crossing Over, Genetic; Epilepsy; Humans; Mutagens; Phenytoin; Sister Chromatid Exchange

1982
[Effectiveness of anticonvulsant monotherapy with phenytoin in relation to its plasma levels].
    Archivos de farmacologia y toxicologia, 1982, Volume: 8, Issue:3

    Topics: Adult; Epilepsy; Humans; Phenytoin

1982
Phenytoin elimination in childhood: effect of concentration-dependent kinetics.
    Neurology, 1980, Volume: 30, Issue:2

    Topics: Adolescent; Adult; Age Factors; Biopharmaceutics; Child; Child, Preschool; Drug Administration Sched

1980
Plasma levels and clinical effects of antiepileptic drugs in pregnant epileptic patients and their newborns.
    Obstetrical & gynecological survey, 1980, Volume: 35, Issue:9

    Topics: Adult; Anticonvulsants; Clonazepam; Epilepsy; Female; Humans; Infant, Newborn; Phenobarbital; Phenyt

1980
Predicting individual phenytoin serum levels of patients seen in a private office practice.
    Neurology, 1981, Volume: 31, Issue:6

    Topics: Epilepsy; Humans; Metabolic Clearance Rate; Phenytoin

1981
Nonlinear kinetics of phenytoin in children.
    Neurology, 1982, Volume: 32, Issue:1

    Topics: Adolescent; Adult; Age Factors; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship,

1982
Cerebellar atrophy in epilepsy and headache: lack of relationship to phenytoin.
    Neurology, 1982, Volume: 32, Issue:8

    Topics: Adolescent; Adult; Atrophy; Cerebellum; Epilepsy; Female; Headache; Humans; Male; Phenytoin; Tomogra

1982
Reversal by phenytoin of carbamazepine-induced water intoxication: a pharmacokinetic interaction.
    Journal of neurology, neurosurgery, and psychiatry, 1980, Volume: 43, Issue:6

    Topics: Adult; Carbamazepine; Drug Antagonism; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Mi

1980
Saliva phenobarbital and phenytoin concentrations in epileptic adolescents.
    The Journal of pediatrics, 1981, Volume: 98, Issue:4

    Topics: Adolescent; Child; Epilepsy; Female; Humans; Male; Patient Compliance; Phenobarbital; Phenytoin; Sal

1981
Mianserin and epilepsy.
    The Medical journal of Australia, 1980, Oct-18, Volume: 2, Issue:8

    Topics: Adult; Depressive Disorder; Dibenzazepines; Epilepsy; Humans; Male; Mianserin; Phenytoin; Seizures

1980
[Medication reliability of epileptic children treated with phenytoin].
    Zeitschrift fur arztliche Fortbildung, 1980, Dec-01, Volume: 74, Issue:23

    Topics: Adolescent; Ambulatory Care; Child; Epilepsy; Female; Humans; Male; Patient Compliance; Phenytoin; S

1980
[Measurements of nerve conduction velocity during decreasing toxic diphenylhydantoin levels and the beginning of carbamazepine medication. A clinical neurophysiological documentation (author's transl)].
    Archiv fur Psychiatrie und Nervenkrankheiten, 1981, Volume: 229, Issue:3

    Topics: Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Humans; Male; Middle Aged; Motor Neurons;

1981
Anterior spinal artery syndrome during the postpartum period.
    Archives of neurology, 1981, Volume: 38, Issue:4

    Topics: Adult; Cerebral Hemorrhage; Epilepsy; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange

1981
[Determination of optimal diphenylhydantoin dosage by monitoring serum concentrations].
    Harefuah, 1980, Oct-15, Volume: 99, Issue:8

    Topics: Aged; Brain; Epilepsy; Humans; Middle Aged; Phenytoin; Postoperative Care

1980
The teratological problem of antiepileptic drugs.
    Folia psychiatrica et neurologica japonica, 1980, Volume: 34, Issue:3

    Topics: Abnormalities, Drug-Induced; Adult; Animals; Anticonvulsants; Chromosome Aberrations; Cleft Lip; Cle

1980
Therapeutic plasma concentration in epileptics treated with phenytoin alone.
    Folia psychiatrica et neurologica japonica, 1980, Volume: 34, Issue:3

    Topics: Epilepsy; Humans; Phenytoin

1980
Clinical effects of phenytoin (PHT) against various epileptic seizure types: investigation on effective serum concentration.
    Folia psychiatrica et neurologica japonica, 1980, Volume: 34, Issue:3

    Topics: Adolescent; Adult; Child; Epilepsy; Female; Humans; Middle Aged; Phenytoin

1980
Michaelis-Menten pharmacokinetics of diphenylhydantoin and application in the pediatric age patient.
    Folia psychiatrica et neurologica japonica, 1980, Volume: 34, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Infant; Kinetics; Phenytoin

1980
Quantitative assessment of smooth-pursuit eye movements in healthy and epileptic subjects.
    Journal of neurology, neurosurgery, and psychiatry, 1980, Volume: 43, Issue:12

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Electrooculography; Epilepsy; Eye Movements; Huma

1980
[Phenobarbital intoxication in a patient with primidone and diphenylhydantoin (author's transl)].
    Revista medica de Chile, 1980, Volume: 108, Issue:8

    Topics: Adult; Drug Interactions; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Primidone

1980
Clinical utility of six methods of predicting phenytoin doses and plasma concentrations.
    American journal of hospital pharmacy, 1981, Volume: 38, Issue:3

    Topics: Adult; Aged; Epilepsy; Female; Humans; Male; Methods; Middle Aged; Patient Compliance; Phenytoin

1981
Rapid infusion of phenytoin sodium loading doses.
    American journal of hospital pharmacy, 1981, Volume: 38, Issue:3

    Topics: Blood Pressure; Epilepsy; Half-Life; Humans; Infusions, Parenteral; Phenytoin

1981
[Influence of anti-epileptic drugs on blood lipid parameters: preliminary data].
    Bollettino della Societa italiana di biologia sperimentale, 1981, Feb-15, Volume: 57, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Cholesterol; Epilepsy; Humans; Lipids; Phenobarbital; Phenytoin; Tri

1981
Ictal effects of anticonvulsant medication withdrawal in epileptic patients.
    Epilepsia, 1981, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy; Humans; Middle

1981
Chromosomal investigations in epileptic children during long-term therapy with phenytoin or primidone.
    Human genetics, 1981, Volume: 56, Issue:3

    Topics: Adolescent; Cells, Cultured; Child; Child, Preschool; Chromosome Aberrations; Chromosomes, Human; Ep

1981
Cardiovascular and hematologic effects of diphenylhydantoin in maternal and fetal sheep.
    Obstetrics and gynecology, 1981, Volume: 58, Issue:1

    Topics: Acid-Base Equilibrium; Alkalosis; Animals; Blood Pressure; Cardiovascular System; Epilepsy; Female;

1981
Phenytoin and IgA concentrations in plasma and saliva in epileptic children.
    Acta paediatrica Scandinavica, 1981, Volume: 70, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Immunoglobulin A; Male; Phenytoin; Sa

1981
[Polytherapy and monotherapy in the treatment of epileptic patients].
    Acta neurologica, 1981, Volume: 3, Issue:1

    Topics: Adult; Computers; Drug Combinations; Epilepsy; Female; Humans; Male; Monitoring, Physiologic; Phenob

1981
[Neurological signs in diphenylhydantoin intoxication (case reports and review) (author's transl)].
    Wiener klinische Wochenschrift, 1981, May-15, Volume: 93, Issue:10

    Topics: Adult; Biopsy; Cerebellar Ataxia; Electroencephalography; Epilepsy; Evoked Potentials; Female; Human

1981
Salivary anticonvulsant levels in children with epilepsy.
    The British journal of clinical practice, 1981, Volume: 35, Issue:1

    Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Epilepsy; Humans; Infant; Phenytoin; Saliva

1981
[Epilepsy and hypocalcemia. Further considerations on a case].
    Acta neurologica. Quaderni, 1981, Volume: 42

    Topics: Adult; Calcium; Epilepsy; Female; Goiter; Humans; Hypocalcemia; Hypoparathyroidism; Phenobarbital; P

1981
Anticonvulsants and pregnancy.
    The Nebraska medical journal, 1981, Volume: 66, Issue:10

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fe

1981
Choreo-athetosis induced by phenytoin in an epileptic child. A case report.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1981, Oct-17, Volume: 60, Issue:16

    Topics: Athetosis; Child, Preschool; Chorea; Epilepsy; Humans; Male; Phenytoin

1981
Effect of phenytoin on immunoglobulin concentrations in nasal secretions.
    Acta pathologica et microbiologica Scandinavica. Section C, Immunology, 1981, Volume: 89, Issue:1

    Topics: Adolescent; Adult; Aged; Albumins; Child; Epilepsy; Humans; Immunoglobulin A; Immunoglobulin G; Immu

1981
Effects of phenytoin withdrawal on matching to sample and workshop performance of mentally retarded persons.
    The Journal of nervous and mental disease, 1981, Volume: 169, Issue:11

    Topics: Adolescent; Adult; Color Perception; Discrimination Learning; Epilepsy; Female; Humans; Intellectual

1981
Chronic anticonvulsive therapy, peripheral nerve conduction velocity, and EMG.
    Epilepsia, 1981, Volume: 22, Issue:6

    Topics: Adult; Anticonvulsants; Electromyography; Epilepsy; Female; Humans; Male; Middle Aged; Neural Conduc

1981
Plasma level analysis of some antiepileptic drugs in 180 patients.
    Monographs in neural sciences, 1980, Volume: 5

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilep

1980
The relationship between the serum levels of phenobarbital and diphenylhydantoin and clinical data in patients with drug resistant epilepsy.
    Monographs in neural sciences, 1980, Volume: 5

    Topics: Adolescent; Adult; Child; Child, Preschool; Drug Resistance; Electroencephalography; Epilepsy; Femal

1980
Possible drug interaction in chronic treatment of epileptic patients: serum level studies.
    Monographs in neural sciences, 1980, Volume: 5

    Topics: Adolescent; Adult; Anticonvulsants; Brain Damage, Chronic; Chronic Disease; Clonazepam; Drug Interac

1980
A follow-up study of 880 adult ambulatory epileptics.
    Monographs in neural sciences, 1980, Volume: 5

    Topics: Adult; Age Factors; Employment; Epilepsy; Female; Follow-Up Studies; Humans; Male; Middle Aged; Phen

1980
Smooth pursuit eye movements in epileptics under antiepileptic medication.
    The Tohoku journal of experimental medicine, 1981, Volume: 134, Issue:4

    Topics: Adult; Aged; Anticonvulsants; Cerebellum; Epilepsy; Eye Movements; Female; Humans; Male; Middle Aged

1981
Phenytoin and phenobarbitone plasma level-dose relationships in Chinese epileptic children in Singapore.
    Therapeutic drug monitoring, 1981, Volume: 3, Issue:3

    Topics: Adolescent; Child; Child, Preschool; China; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; P

1981
Role of carbamazepine in reducing polypharmacy in epilepsy.
    Acta neurologica Scandinavica, 1981, Volume: 64, Issue:1

    Topics: Acetazolamide; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Ther

1981
Folic acid absorption test in various clinical conditions.
    Annals of nutrition & metabolism, 1981, Volume: 25, Issue:6

    Topics: Adult; Aged; Atrophy; Diabetes Mellitus; Epilepsy; Folic Acid; Gastrointestinal Diseases; Humans; Hy

1981
Protein-bound and free plasma phenytoin during pregnancy.
    International journal of biological research in pregnancy, 1981, Volume: 2, Issue:2

    Topics: Blood Proteins; Epilepsy; Female; Fetus; Humans; Ovulation Induction; Phenytoin; Pregnancy; Pregnanc

1981
[Monotherapy or polytherapy in epilepsy?].
    Revista de medicina de la Universidad de Navarra, 1981, Volume: 25, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Combinations; Drug Evaluation; Drug I

1981
Serum phenytoin concentration and clinical response in patients with epilepsy.
    British journal of clinical pharmacology, 1981, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Epilepsy; Female; Handwriting; Humans; Male; Memory, Short-Term; Middle Aged; Mot

1981
[Diphenylhydantoin, epilepsy, cerebellar atrophy--histological and electron microscope examinations (author's transl)].
    Fortschritte der Neurologie-Psychiatrie, 1981, Volume: 49, Issue:11

    Topics: Adult; Atrophy; Cerebellar Diseases; Cerebellum; Endoplasmic Reticulum; Epilepsy; Female; Humans; Ma

1981
[Bioavailability of phenytoin. Comparison of data obtained in vitro, in healthy volunteers and in epileptic patients].
    Bollettino chimico farmaceutico, 1981, Volume: 120, Issue:12

    Topics: Adolescent; Adult; Biological Availability; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin

1981
[Diagnosis of osteopathy caused by antiepileptic drugs].
    Zeitschrift fur arztliche Fortbildung, 1981, Aug-01, Volume: 75, Issue:15

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Bone Diseases; Carbamazepine; Epilepsy; Female; Femur; Han

1981
Apparent Michaelis-Menten kinetic parameters of phenytoin in pediatric patients.
    Pediatric pharmacology (New York, N.Y.), 1980, Volume: 1, Issue:2

    Topics: Adolescent; Aging; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Hu

1980
From the NIH: Some side effects of phenytoin are studied.
    JAMA, 1980, Mar-14, Volume: 243, Issue:10

    Topics: Adult; Animals; Blood; Child; Epilepsy; Female; Fetus; Gingiva; Gingival Hypertrophy; Humans; Matern

1980
Micropsia: an uncommon pediatric symptom.
    Clinical pediatrics, 1980, Volume: 19, Issue:4

    Topics: Child; Epilepsy; Humans; Male; Phenytoin; Size Perception; Vision Disorders

1980
Improvement in antiepileptic drug levels following reduction of intervals between clinic visits.
    Epilepsia, 1980, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Appointments and Schedules; Carbamazepine; Epilepsy; Ethosuximid

1980
Reduced seizure control due to spoiled phenytoin capsules.
    Annals of neurology, 1980, Volume: 7, Issue:2

    Topics: Adult; Biological Availability; Drug Stability; Drug Storage; Epilepsy; Humans; Humidity; Male; Phen

1980
Plasma high-density lipoprotein cholesterol in epileptics treated with various anticonvulsants.
    European neurology, 1980, Volume: 19, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Cholesterol; Epilepsy; Female; Humans; Lipoproteins, HDL; Mal

1980
The syndrome of aphasia, headaches, and left temporal spikes.
    Headache, 1980, Volume: 20, Issue:2

    Topics: Adult; Aphasia; Electroencephalography; Epilepsy; Female; Headache; Humans; Middle Aged; Phenytoin;

1980
Antiepileptic drug distribution in cerebral cortex, ammon's horn, and amygdala in man.
    Journal of neurosurgery, 1980, Volume: 52, Issue:5

    Topics: Adolescent; Adult; Amygdala; Anticonvulsants; Carbamazepine; Cerebral Cortex; Child; Epilepsy; Femal

1980
[Paroxysmal dyskinesia during treatment with diphenylhydantoin].
    Revue neurologique, 1980, Volume: 136, Issue:1

    Topics: Adult; Brain Diseases; Child; Child, Preschool; Diazepam; Dyskinesia, Drug-Induced; Epilepsy; Female

1980
Multivariate statistical methods in toxicology: application to the analysis of outpatient clinical data for diphenylhydantoin and phenobarbital in the treatment of epilepsy.
    Toxicology and applied pharmacology, 1980, Volume: 53, Issue:2

    Topics: Adolescent; Adult; Aging; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Sex

1980
Inhibition of collagen breakdown by diphenylhydantoin.
    Biochimica et biophysica acta, 1980, Aug-01, Volume: 631, Issue:1

    Topics: Carbon Radioisotopes; Cells, Cultured; Collagen; Depression, Chemical; DNA; Epilepsy; Female; Gingiv

1980
Monitoring 2-ethyl-2-phenylmalonamide in serum by gas-liquid chromatography: application to retrospective study in epilepsy patients dosed with primidone.
    Clinical chemistry, 1980, Volume: 26, Issue:11

    Topics: Adult; Carbamazepine; Chromatography, Gas; Drug Interactions; Epilepsy; Humans; Malonates; Middle Ag

1980
Fetal hydantoin syndrome, neuroblastoma, and hemorrhagic disease in a neonate.
    JAMA, 1980, Sep-26, Volume: 244, Issue:13

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Epilepsy; Female; Humans; Hydantoins; Infant,

1980
Antiepileptic drugs, the developing nervous system, and the pregnant woman with epilepsy.
    JAMA, 1980, Sep-26, Volume: 244, Issue:13

    Topics: Abnormalities, Drug-Induced; Central Nervous System; Epilepsy; Female; Fetus; Humans; Infant, Newbor

1980
[Panmyelopathy in combined epilepsy therapy using ethosuccimide, diphenylhydantoin, and phenobarbital in childhood].
    Kinderarztliche Praxis, 1980, Volume: 48, Issue:6

    Topics: Child; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Humans; Pancytopenia; Phenobarbita

1980
Phenytoin metabolism in pregnancy.
    Obstetrics and gynecology, 1980, Volume: 56, Issue:5

    Topics: Adult; Epilepsy; Female; Fetal Blood; Humans; Kinetics; Phenytoin; Pregnancy; Pregnancy Complication

1980
Practical and theoretical aspects of phenytoin administration. I. Relationship between dose and plasma concentration.
    European neurology, 1980, Volume: 19, Issue:6

    Topics: Adult; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital;

1980
Arrhythmogenic epilepsy: an hypothesis.
    American heart journal, 1980, Volume: 100, Issue:5

    Topics: Adolescent; Adult; Arrhythmias, Cardiac; Carbamazepine; Digoxin; Electroencephalography; Electrophys

1980
Anticonvulsant-induced unclassified porphyria.
    The International journal of biochemistry, 1980, Volume: 12, Issue:5-6

    Topics: Adult; Aminolevulinic Acid; Anticonvulsants; Diagnosis, Differential; Epilepsy; Humans; Male; Phenob

1980
[Failure of diphenylhydantoin treatment in children].
    Harefuah, 1980, Volume: 99, Issue:1-2

    Topics: Child; Epilepsy; Humans; Patient Compliance; Phenytoin

1980
Rapid quantitative determination of underivatized carbamazepine, phenytoin, phenobarbital and p-hydroxyphenobarbital in biological fluids by packed column gas chromatography.
    Journal of chromatography, 1980, Nov-14, Volume: 221, Issue:1

    Topics: Adult; Carbamazepine; Chromatography, Gas; Epilepsy; Female; Gas Chromatography-Mass Spectrometry; H

1980
Phenytoin-induced teratogenesis: a mouse model.
    Science (New York, N.Y.), 1981, Jan-30, Volume: 211, Issue:4481

    Topics: Animals; Disease Models, Animal; Epilepsy; Female; Mice; Mice, Neurologic Mutants; Phenytoin; Terato

1981
[Reflections on epileptic personality changes].
    Folia psychiatrica et neurologica japonica, 1980, Volume: 34, Issue:2

    Topics: Epilepsy; Female; Humans; Middle Aged; Personality; Personality Disorders; Phenytoin; Psychotherapy;

1980
Hospital prescribing of phenytoin for epilepsy.
    Journal of the Royal College of Physicians of London, 1981, Volume: 15, Issue:1

    Topics: Adult; Drug Administration Schedule; Drug Therapy, Combination; England; Epilepsy; Humans; Outpatien

1981
Respiratory disease and nasal immunoglobulin concentrations in phenytoin-treated epileptic patients.
    Acta neurologica Scandinavica, 1981, Volume: 63, Issue:1

    Topics: Epilepsy; Humans; Immunoglobulins; Nasal Mucosa; Phenytoin; Respiratory Tract Diseases

1981
Power spectral analysis of EEG characteristics during sleep in epileptics.
    Epilepsia, 1981, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Carbamazepine; Circadian Rhythm; Electroencephalography; Epilepsy; Ethosuximide;

1981
Diphenylhydantoin and primidone in tears.
    Epilepsia, 1981, Volume: 22, Issue:2

    Topics: Adult; Child; Epilepsy; Female; Humans; Male; Phenytoin; Primidone; Saliva; Tears

1981
Effect of chronic administration of phenytoin on regional monoamine levels in rat brain.
    Neurochemical research, 1995, Volume: 20, Issue:7

    Topics: Animals; Anticonvulsants; Brain; Chromatography, High Pressure Liquid; Dopamine; Epilepsy; Injection

1995
Practical considerations in anticonvulsant therapy--Part 2.
    American pharmacy, 1995, Volume: NS35, Issue:9

    Topics: Anticonvulsants; Benzodiazepines; Cost Control; Epilepsy; Ethosuximide; Humans; Monitoring, Physiolo

1995
[A change in the thyroid status of children with epilepsy being treated with diphenylhydantoin].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1995, Volume: 95, Issue:3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Hu

1995
Automated analysis of free and total concentrations of three antiepileptic drugs in plasma with on-line dialysis and high-performance liquid chromatography.
    Journal of chromatography. B, Biomedical applications, 1995, Jul-21, Volume: 669, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Dialysis; Epilepsy; Humans; Ph

1995
Positron emission tomographic study of late-onset cryptogenic symptomatic seizures.
    Clinical neurology and neurosurgery, 1995, Volume: 97, Issue:3

    Topics: Aged; Aged, 80 and over; Blood Flow Velocity; Brain Damage, Chronic; Cerebral Cortex; Diagnosis, Dif

1995
Red cell folate levels in pregnant epileptic women.
    European journal of clinical pharmacology, 1995, Volume: 48, Issue:3-4

    Topics: Adult; Carbamazepine; Epilepsy; Erythrocytes; Female; Folic Acid; Follow-Up Studies; Humans; Phenyto

1995
Carbamazepine, phenytoin, sex hormones, and sexual function in men with epilepsy.
    Epilepsia, 1995, Volume: 36, Issue:4

    Topics: Adolescent; Adult; Carbamazepine; Epilepsy; Follow-Up Studies; Humans; Male; Middle Aged; Phenytoin;

1995
[Persistent cerebellar ataxia after toxic administration of diphenylhydantoin].
    Arquivos de neuro-psiquiatria, 1994, Volume: 52, Issue:4

    Topics: Arachnoid Cysts; Brain Diseases; Cerebellar Ataxia; Epilepsy; Humans; Male; Middle Aged; Phenytoin;

1994
Interactions of phenobarbital and phenytoin with carbamazepine and its metabolites' concentrations, concentration ratios, and level/dose ratios in epileptic children.
    Epilepsia, 1995, Volume: 36, Issue:3

    Topics: Biotransformation; Carbamazepine; Child; Chromatography, High Pressure Liquid; Dose-Response Relatio

1995
[NONMEM approach for estimating population pharmacokinetic parameters of phenytoin in Chinese epileptics].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1995, Volume: 30, Issue:3

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Middle Aged; Model

1995
Metabolism of carbamazepine and co-administered anticonvulsants during pregnancy.
    Epilepsy research, 1995, Volume: 21, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenytoi

1995
Anticonvulsant effect of intraventricular antiepileptic drugs. Experimental study.
    Neurological research, 1995, Volume: 17, Issue:3

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Injections, Intraventricul

1995
Predicting unbound phenytoin concentrations in patients receiving valproic acid: a comparison of two prediction methods.
    The Annals of pharmacotherapy, 1995, Volume: 29, Issue:5

    Topics: Adult; Bias; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Pred

1995
Is there a pathophysiological and therapeutic link between panic disorder and epilepsy?
    Acta psychiatrica Scandinavica, 1995, Volume: 91, Issue:6

    Topics: Adult; Brain; Carbamazepine; Electroencephalography; Epilepsy; Female; Humans; Magnetic Resonance Im

1995
Humoral and cellular immune parameters in untreated and phenytoin-or carbamazepine-treated epileptic patients.
    International journal of immunopharmacology, 1994, Volume: 16, Issue:12

    Topics: Adolescent; Adult; Aged; Antibody Formation; B-Lymphocytes; Carbamazepine; Complement C3; Complement

1994
Effect of phenytoin on phenobarbital pharmacokinetics in a patient with epilepsy.
    The Annals of pharmacotherapy, 1995, Volume: 29, Issue:1

    Topics: Adult; Drug Interactions; Drug Monitoring; Epilepsy; Female; Humans; Phenobarbital; Phenytoin

1995
Drugs for epilepsy.
    The Medical letter on drugs and therapeutics, 1995, Apr-28, Volume: 37, Issue:947

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin

1995
[Disorders of color perception and increase glare sensitivity in phenytoin and carbamazepine therapy. Ocular side effects of anticonvulsants].
    Der Nervenarzt, 1995, Volume: 66, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Color Perception Tests; Color Vision Defec

1995
Preventing omission errors.
    The American journal of nursing, 1995, Volume: 95, Issue:4

    Topics: Accidental Falls; Epilepsy; Female; Humans; Mandibular Fractures; Medication Errors; Middle Aged; Ph

1995
[Sensitive physiologic perceptual tests for ocular side effects of drugs exemplified by various anticonvulsants].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1995, Volume: 92, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Color Perception; Contrast Sensitivity; Da

1995
[Changes in drug therapy and in seizure frequency in an institution for epilepsy patients between 1971 and 1986].
    Die Rehabilitation, 1994, Volume: 33, Issue:4

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Barbiturates; Carbamazepine; Drug Therapy, Combination; Dr

1994
Antiepileptic treatment and risk for hepatobiliary cancer and malignant lymphoma.
    Cancer research, 1995, Jan-15, Volume: 55, Issue:2

    Topics: Aged; Aged, 80 and over; Biliary Tract Neoplasms; Case-Control Studies; Epilepsy; Female; Humans; Li

1995
Differential up-regulation of voltage-dependent Na+ channels induced by phenytoin in brains of genetically seizure-susceptible (E1) and control (ddY) mice.
    Neuroscience, 1994, Volume: 62, Issue:3

    Topics: Amphibian Proteins; Animals; Carrier Proteins; Cerebral Cortex; Epilepsy; Mice; Mice, Neurologic Mut

1994
Comparison of community and institutional prescription of antiepileptic drugs for individuals with learning disabilities.
    Journal of intellectual disability research : JIDR, 1994, Volume: 38 ( Pt 6)

    Topics: Adult; Ambulatory Care; Anticonvulsants; Cognition Disorders; Day Care, Medical; Drug Therapy, Combi

1994
A comparative study of serum F protein and other liver function tests as an index of hepatocellular damage in epileptic patients.
    Acta neurologica Scandinavica, 1994, Volume: 89, Issue:4

    Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Aspartate Aminotransferases; Carbamazepine; Chemical a

1994
Delayed fatal agranulocytosis in an epileptic taking primidone and phenytoin.
    Lancet (London, England), 1994, Jul-30, Volume: 344, Issue:8918

    Topics: Adult; Agranulocytosis; Drug Therapy, Combination; Epilepsy; Fatal Outcome; Humans; Male; Phenytoin;

1994
Antiepileptics in the elderly. Pharmacoepidemiology and pharmacokinetics.
    Archives of family medicine, 1994, Volume: 3, Issue:7

    Topics: Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; H

1994
Basilar invagination and mid-line skeletal abnormalities due to in utero exposure to phenytoin.
    British journal of neurosurgery, 1994, Volume: 8, Issue:3

    Topics: Adult; Arnold-Chiari Malformation; Bone Transplantation; Cleft Lip; Cleft Palate; Diseases in Twins;

1994
Changes of thyroid hormone levels in epileptic patients.
    Journal of Tongji Medical University = Tong ji yi ke da xue xue bao, 1994, Volume: 14, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Phenytoin; Thyrotropin; Thyro

1994
Epilepsy treatment in The Netherlands. Comparison of matched groups of two medical centres.
    Acta neurologica Scandinavica, 1994, Volume: 89, Issue:6

    Topics: Adolescent; Adult; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Female; gamma-Aminobutyric Acid;

1994
Ataxia in institutionalized patients with epilepsy.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1994, Volume: 21, Issue:3

    Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Anticonvulsants; Ataxia; Cerebellar Ataxia; Epilepsy;

1994
MDR1 gene expression in brain of patients with medically intractable epilepsy.
    Epilepsia, 1995, Volume: 36, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain;

1995
Phenytoin overdosage and cerebellar atrophy in epileptic patients: clinical and MRI findings.
    European neurology, 1994, Volume: 34 Suppl 1

    Topics: Adult; Atrophy; Cerebellar Diseases; Cerebellum; Drug Overdose; Epilepsy; Female; Humans; Magnetic R

1994
Holoprosencephaly and the teratogenicity of anticonvulsants.
    Teratology, 1994, Volume: 49, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Face; Female; Finge

1994
Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy.
    Archives of neurology, 1994, Volume: 51, Issue:8

    Topics: Adult; Atrophy; Cerebellum; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin

1994
Bone mineral density measured by dual-energy x-ray absorptiometry and novel markers of bone formation and resorption in patients on antiepileptic drugs.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1994, Volume: 9, Issue:5

    Topics: Absorptiometry, Photon; Adult; Alkaline Phosphatase; Bone Density; Bone Development; Bone Resorption

1994
Effect of phenytoin on cortical epileptic foci in cerveau isolé rats.
    Physiological research, 1994, Volume: 43, Issue:1

    Topics: Animals; Brain Stem; Cerebral Cortex; Cortical Synchronization; Decerebrate State; Electroencephalog

1994
Status epilepticus: management and outcome of 107 episodes.
    Seizure, 1994, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Aged; Chlormethiazole; Clinical Protocols; Diazepam; Epilepsy; Female; Humans; In

1994
Interaction between phenytoin and fluoxetine.
    Seizure, 1994, Volume: 3, Issue:2

    Topics: Adult; Depressive Disorder; Dose-Response Relationship, Drug; Epilepsy; Fluoxetine; Humans; Male; Ph

1994
Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat.
    Epilepsy research, 1993, Volume: 15, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Amino Acids, Cyclic; Analysis of Var

1993
Dihydropyridine group of calcium channel antagonist in epilepsy.
    Indian journal of physiology and pharmacology, 1994, Volume: 38, Issue:1

    Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Electrodes, Implanted; Electroencephalography;

1994
Kohlschütter syndrome: syndrome of epilepsy--dementia--amelogenesis imperfecta.
    Neuropediatrics, 1993, Volume: 24, Issue:6

    Topics: Amelogenesis Imperfecta; Brain; Dementia; Epilepsy; Female; Humans; Infant; Male; Phenytoin; Psychom

1993
Pharmacodynamic interactions between phenytoin and valproate: individual and combined antiepileptic and neurotoxic actions in mice.
    Clinical neuropharmacology, 1994, Volume: 17, Issue:1

    Topics: Animals; Brain; Brain Diseases; Drug Interactions; Drug Synergism; Electroshock; Epilepsy; Female; M

1994
Carbamazepine offers no psychotropic advantage over phenytoin in adult epileptic subjects.
    Seizure, 1993, Volume: 2, Issue:1

    Topics: Adult; Carbamazepine; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Humans; In

1993
Pregnancy, epilepsy, management and outcome: a 10-year perspective.
    Seizure, 1993, Volume: 2, Issue:4

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Birth Weight; Carbamazepine; Cohort Studies; Drug Ther

1993
Acute psychosis and epileptic seizures as the presenting symptom of late-onset epilepsy.
    Acta neurologica Scandinavica, 1994, Volume: 89, Issue:1

    Topics: Aged; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalo

1994
[Gelastic seizures, precocious puberty and hypothalamic hamartomas. A case report and the contributions of Single Photon Emission Computed Tomography (SPECT)].
    Neurologia (Barcelona, Spain), 1994, Volume: 9, Issue:2

    Topics: Adolescent; Epilepsy; Female; Hamartoma; Humans; Hypothalamus; Laughter; Magnetic Resonance Imaging;

1994
[Repetitive serum determinations of anticonvulsants in epileptic patients].
    Arquivos de neuro-psiquiatria, 1993, Volume: 51, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Chronic Disease; Epilepsy; Female; Humans; Middle

1993
Effects of non-opioid antitussives on hypoxia-induced electrical changes in rat hippocampal slices: a comparative study with anticonvulsant drugs.
    General pharmacology, 1993, Volume: 24, Issue:4

    Topics: Animals; Anticonvulsants; Antitussive Agents; Cyclopentanes; Dizocilpine Maleate; Electrophysiology;

1993
Neurophysiologic and clinical correlations of epileptic nystagmus.
    Neurology, 1993, Volume: 43, Issue:12

    Topics: Adult; Aged; Child; Consciousness; Diazepam; Electroencephalography; Epilepsy; Eye Movements; Female

1993
Metabolic bone disease (anticonvulsant osteomalacia) and renal tubular acidosis in tuberous sclerosis.
    Internal medicine (Tokyo, Japan), 1993, Volume: 32, Issue:7

    Topics: Acidosis, Renal Tubular; Adult; Back Pain; Bicarbonates; Bone and Bones; Calcitriol; Calcium; Calciu

1993
Phenytoin toxicity due to rifampicin induced hepatic dysfunction.
    The Journal of the Association of Physicians of India, 1993, Volume: 41, Issue:8

    Topics: Chemical and Drug Induced Liver Injury; Child; Drug Interactions; Epilepsy; Female; Humans; Isoniazi

1993
Automated determination of free phenytoin in human plasma with on-line equilibrium dialysis and column-switching high-performance liquid chromatography.
    Journal of chromatography, 1993, Nov-24, Volume: 621, Issue:2

    Topics: Autoanalysis; Blood Proteins; Chromatography, High Pressure Liquid; Dialysis; Epilepsy; Humans; Phen

1993
Immunoglobulin A levels in serum and saliva of patients treated with phenytoin.
    The Journal of Nihon University School of Dentistry, 1993, Volume: 35, Issue:1

    Topics: Adolescent; Adult; Dental Plaque Index; Epilepsy; Female; Gingival Hyperplasia; Humans; Immunoglobul

1993
Unmasking the significant enzyme-inducing effects of phenytoin on serum carbamazepine concentrations during phenytoin withdrawal.
    The Annals of pharmacotherapy, 1993, Volume: 27, Issue:6

    Topics: Adult; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Enzyme Induction; Epilepsy; Huma

1993
Effect of barbiturate therapy on phenytoin pharmacokinetics.
    Critical care medicine, 1993, Volume: 21, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Critical Illness; Epilepsy; Female; Humans; Intracranial Pressure; M

1993
Free phenytoin monitoring in serum and saliva of epileptic patients in China.
    Therapeutic drug monitoring, 1993, Volume: 15, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; China; Dialysis; Drug Monitoring; Epilepsy; Female; Fluores

1993
Five years of anticonvulsant monitoring on site at the epilepsy clinic.
    Therapeutic drug monitoring, 1993, Volume: 15, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; Outpatient Clinics, Hospital; Phe

1993
An audit of therapeutic drug monitoring of anticonvulsants.
    The Ulster medical journal, 1995, Volume: 64, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Monitoring; Epilepsy; Humans; Medical Audit; Nort

1995
Phenytoin serum concentration monitoring during pregnancy and puerperium in Mexican epileptic women.
    Archives of medical research, 1995,Winter, Volume: 26, Issue:4

    Topics: Adolescent; Adult; Epilepsy; Female; Humans; Male; Phenytoin; Postpartum Period; Pregnancy; Pregnanc

1995
A model for estimating individualized valproate clearance values in children.
    Journal of clinical pharmacology, 1995, Volume: 35, Issue:10

    Topics: Administration, Oral; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Ther

1995
Lack of effect of histological lesions on the phenytoin and phenobarbital concentrations in the brain cortex of epileptic patients.
    Journal of the neurological sciences, 1995, Volume: 133, Issue:1-2

    Topics: Aged; Aged, 80 and over; Case-Control Studies; Cerebellum; Cerebral Cortex; Child, Preschool; Epilep

1995
Concentrations and effects of oral midazolam are greatly reduced in patients treated with carbamazepine or phenytoin.
    Epilepsia, 1996, Volume: 37, Issue:3

    Topics: Administration, Oral; Adult; Carbamazepine; Drug Interactions; Enzyme Induction; Epilepsy; Female; F

1996
Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models.
    Epilepsia, 1996, Volume: 37, Issue:3

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Phenobarbita

1996
Pharmacology of cortical epileptic afterdischarges in rats.
    Epilepsia, 1996, Volume: 37, Issue:4

    Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Dimethyl Sulfoxide; Disease Models, Animal

1996
Anticonvulsants.
    RDH, 1994, Volume: 14, Issue:9

    Topics: Anticonvulsants; Dental Care for Chronically Ill; Drug Interactions; Epilepsy; Gingival Hyperplasia;

1994
Effect of valproate on cerebral metabolism and blood flow: an 18F-2-deoxyglucose and 15O water positron emission tomography study.
    Epilepsia, 1996, Volume: 37, Issue:6

    Topics: Adult; Brain; Carbamazepine; Cerebrovascular Circulation; Deoxyglucose; Dose-Response Relationship,

1996
Use of parenteral antiepileptic drugs and the role for fosphenytoin.
    Neurology, 1996, Volume: 46, Issue:6 Suppl 1

    Topics: Anticonvulsants; Epilepsy; Humans; Infusions, Parenteral; Phenytoin

1996
[Study of the influence of anticonvulsant treatment on thyroid function].
    Anales de medicina interna (Madrid, Spain : 1984), 1995, Volume: 12, Issue:12

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Enzyme-Linked Immunosorbent Assay; E

1995
Influence of D-cycloserine on the anticonvulsant activity of phenytoin and carbamazepine against electroconvulsions in mice.
    Epilepsia, 1996, Volume: 37, Issue:7

    Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Carbamazepine; Cycloserine; Disease

1996
[Subependymal nodular heterotopia and epilepsy].
    Neurologia (Barcelona, Spain), 1996, Volume: 11, Issue:1

    Topics: Age of Onset; Anticonvulsants; Brain; Choristoma; Epilepsy; Female; Humans; Middle Aged; Pedigree; P

1996
Anticonvulsant activity of topiramate and phenytoin in a rat model of ischemia-induced epilepsy.
    Life sciences, 1996, Volume: 59, Issue:10

    Topics: Acoustic Stimulation; Animals; Anticonvulsants; Brain Ischemia; Epilepsy; Fructose; Male; Phenytoin;

1996
Plasma and saliva concentrations of phenytoin and 5-(4-hydroxyphenyl)-5-phenylhydantoin in relation to the incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients.
    Journal of periodontology, 1996, Volume: 67, Issue:6

    Topics: Adult; Aged; Anticonvulsants; Epilepsy; Female; Gingival Hyperplasia; Humans; Male; Middle Aged; Phe

1996
Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study.
    Journal of clinical pharmacy and therapeutics, 1996, Volume: 21, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Half-Life; Humans; Metabolic Clearance Rate

1996
A combined cobalt and C-14 2-deoxyglucose approach to antiepileptic drug assessment.
    The International journal of neuroscience, 1996, Volume: 86, Issue:1-2

    Topics: Animals; Anticonvulsants; Antimetabolites; Autoradiography; Brain Chemistry; Cobalt; Deoxyglucose; D

1996
Magnetic resonance volumetry of the cerebellum in epileptic patients after phenytoin overdosages.
    European neurology, 1996, Volume: 36, Issue:5

    Topics: Adult; Cerebellum; Drug Overdose; Epilepsy; Female; Humans; Magnetic Resonance Imaging; Male; Middle

1996
The necessity of adjusting the dosage of zonisamide when coadministered with other anti-epileptic drugs.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:8

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combinatio

1996
Effect of CYP2C polymorphisms on the pharmacokinetics of phenytoin in Japanese patients with epilepsy.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:8

    Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Sys

1996
Salivary protein composition in epileptic patients on different medications.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1996, Volume: 25, Issue:7

    Topics: Adult; Aged; Albumins; Amylases; Anticonvulsants; Carbamazepine; Cystatin C; Cystatins; Cysteine Pro

1996
Drugs and brain death.
    The Medical journal of Australia, 1996, Oct-07, Volume: 165, Issue:7

    Topics: Adult; Australia; Brain Death; Brain Injuries; Cause of Death; Coroners and Medical Examiners; Epile

1996
EBV-positive non-Hodgkin's lymphoma developing after phenytoin therapy.
    British journal of haematology, 1996, Volume: 95, Issue:2

    Topics: Anticonvulsants; Antigens, CD20; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoco

1996
Reduced plasma nisoldipine concentrations in phenytoin-treated patients with epilepsy.
    Epilepsia, 1996, Volume: 37, Issue:11

    Topics: Adult; Contraindications; Delayed-Action Preparations; Drug Interactions; Epilepsy; Female; Humans;

1996
Severe transitory encephalopathy with reversible lesions of the claustrum.
    Pediatric radiology, 1996, Volume: 26, Issue:11

    Topics: Aphasia; Basal Ganglia Diseases; Blindness; Child; Deafness; Epilepsies, Myoclonic; Epilepsy; Epilep

1996
Fosphenytoin safety and economics.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1996, Nov-15, Volume: 53, Issue:22

    Topics: Anticonvulsants; Epilepsy; Humans; Phenytoin; Prescription Fees; Prodrugs

1996
Valproate metabolites in high-dose valproate plus phenytoin therapy.
    Epilepsia, 1996, Volume: 37, Issue:12

    Topics: Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injur

1996
Relationship between ischemic damage and concentrations of phenytoin and phenobarbital in the brain cortex of epileptic patients in vegetative state at death.
    Epilepsy research, 1996, Volume: 25, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Autopsy; Brain Ischemia; Case-Control Studies; Cere

1996
Effects of various valproic acid derivatives on low-calcium spontaneous epileptiform activity in hippocampal slices.
    Epilepsy research, 1995, Volume: 22, Issue:3

    Topics: Animals; Anticonvulsants; Calcium; Carbohydrates; Electroshock; Epilepsy; Hippocampus; In Vitro Tech

1995
Reactions to fosphenytoin editorial and review article.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1997, Feb-15, Volume: 54, Issue:4

    Topics: Anticonvulsants; Cost Savings; Epilepsy; Humans; Phenytoin

1997
Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy.
    Indian journal of physiology and pharmacology, 1996, Volume: 40, Issue:4

    Topics: Animals; Anticonvulsants; Body Temperature; Calcium Channel Blockers; Disease Models, Animal; Electr

1996
Phenytoin monitoring in pregnancy and puerperium.
    Archives of medical research, 1997,Spring, Volume: 28, Issue:1

    Topics: Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications; Puerperal Disorders

1997
Phenytoin-mediated oxidative stress in serum of female epileptics: a possible pathogenesis in the fetal hydantoin syndrome.
    Human & experimental toxicology, 1997, Volume: 16, Issue:3

    Topics: Analysis of Variance; Anticonvulsants; Copper; Epilepsy; Female; Glutathione; Humans; Lipid Peroxida

1997
Single oral loading dose of phenytoin: a pharmacokinetics study.
    Journal of the neurological sciences, 1997, Mar-20, Volume: 147, Issue:1

    Topics: Administration, Oral; Adult; Anticonvulsants; Case-Control Studies; Epilepsy; Female; Half-Life; Hum

1997
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
    European journal of pharmacology, 1997, Mar-26, Volume: 323, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1997
Color vision tests for early detection of antiepileptic drug toxicity.
    Neurology, 1997, Volume: 48, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Color Perception; Epilepsy; Humans; Osmolar Conce

1997
Topiramate for epilepsy.
    The Medical letter on drugs and therapeutics, 1997, May-23, Volume: 39, Issue:1001

    Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Int

1997
Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis.
    Epilepsia, 1997, Volume: 38, Issue:6

    Topics: Animals; Anticonvulsants; Behavior, Animal; Brain Stem; Disease Models, Animal; Dizocilpine Maleate;

1997
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
    Journal of neurophysiology, 1997, Volume: 77, Issue:6

    Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran

1997
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
    Journal of neurophysiology, 1997, Volume: 77, Issue:6

    Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran

1997
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
    Journal of neurophysiology, 1997, Volume: 77, Issue:6

    Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran

1997
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
    Journal of neurophysiology, 1997, Volume: 77, Issue:6

    Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran

1997
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
    Journal of neurophysiology, 1997, Volume: 77, Issue:6

    Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran

1997
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
    Journal of neurophysiology, 1997, Volume: 77, Issue:6

    Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran

1997
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
    Journal of neurophysiology, 1997, Volume: 77, Issue:6

    Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran

1997
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
    Journal of neurophysiology, 1997, Volume: 77, Issue:6

    Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran

1997
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
    Journal of neurophysiology, 1997, Volume: 77, Issue:6

    Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran

1997
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
    Journal of neurophysiology, 1997, Volume: 77, Issue:6

    Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran

1997
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
    Journal of neurophysiology, 1997, Volume: 77, Issue:6

    Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran

1997
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
    Journal of neurophysiology, 1997, Volume: 77, Issue:6

    Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran

1997
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
    Journal of neurophysiology, 1997, Volume: 77, Issue:6

    Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran

1997
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
    Journal of neurophysiology, 1997, Volume: 77, Issue:6

    Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran

1997
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
    Journal of neurophysiology, 1997, Volume: 77, Issue:6

    Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran

1997
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
    Journal of neurophysiology, 1997, Volume: 77, Issue:6

    Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran

1997
[Therapy of the status epilepticus].
    Der Nervenarzt, 1994, Volume: 65, Issue:1 Suppl [t

    Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Diagnosis, Differential; Epilepsy; Epilepsy, Tonic-C

1994
Bone status after long-term anticonvulsant therapy in epileptic patients: evaluation using quantitative ultrasound of calcaneus and phalanges.
    Ultrasound in medicine & biology, 1997, Volume: 23, Issue:4

    Topics: Adult; Anticonvulsants; Calcaneus; Carbamazepine; Case-Control Studies; Drug Therapy, Combination; E

1997
Decreased total antioxidant capacity and elevated lipid hydroperoxide concentrations in sera of epileptic patients receiving phenytoin.
    Life sciences, 1997, Volume: 61, Issue:4

    Topics: Antioxidants; Cholesterol; Epilepsy; Free Radicals; Humans; Lipid Peroxidation; Lipid Peroxides; Oxi

1997
AWD 140-190: a new anticonvulsant with a very good margin of safety.
    Epilepsy research, 1997, Volume: 28, Issue:1

    Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; E

1997
[Pharmacokinetic variations in anticonvulsants in Mexican epileptic women during different stages of the postpartum period].
    Ginecologia y obstetricia de Mexico, 1997, Volume: 65

    Topics: Animals; Anticonvulsants; Carbamazepine; Cricetinae; Epilepsy; Female; Humans; Milk, Human; Phenytoi

1997
Single-point phenytoin dosage predictions in Singapore Chinese.
    Journal of clinical pharmacy and therapeutics, 1997, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Drug Monitoring; Epilepsy; Female

1997
Huge ossified crust-like subdural hematoma covering the hemisphere and causing acute signs of increased intracranial pressure.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 1997, Volume: 13, Issue:7

    Topics: Adolescent; Anticonvulsants; Brain Diseases; Calcinosis; Epilepsy; Hematoma, Subdural; Humans; Intra

1997
Extrashot-ODS, a syringe-type minicolumn sample injector for a reversed-phase high-performance liquid chromatographic column. Application to antiepileptics in human sera.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Aug-01, Volume: 695, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Epi

1997
Phenytoin's effect on the spread of seizure activity in the amygdala kindling model.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:3

    Topics: Animals; Anticonvulsants; Brain; Electroencephalography; Epilepsy; Female; Kindling, Neurologic; Mal

1997
Influence of phenytoin on cortical epileptic afterdischarges.
    Sbornik lekarsky, 1996, Volume: 97, Issue:4

    Topics: Animals; Anticonvulsants; Cerebral Cortex; Electric Stimulation; Electroencephalography; Epilepsy; P

1996
If a first antiepileptic drug fails to control a child's epilepsy, what are the chances of success with the next drug?
    The Journal of pediatrics, 1997, Volume: 131, Issue:6

    Topics: Age of Onset; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cohort Studies; Drug Administ

1997
Weak blockade of AMPA receptor-mediated depolarisations in the rat cortical wedge by phenytoin but not lamotrigine or carbamazepine.
    European journal of pharmacology, 1997, Oct-22, Volume: 337, Issue:2-3

    Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Epilepsy; Evoked Potentials; Excitatory Am

1997
BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy.
    European journal of pharmacology, 1997, Nov-19, Volume: 339, Issue:1

    Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response R

1997
Risk of seizures from concomitant use of ciprofloxacin and phenytoin in patients with epilepsy.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1998, Jan-13, Volume: 158, Issue:1

    Topics: Anti-Infective Agents; Anticonvulsants; Ciprofloxacin; Drug Interactions; Epilepsy; Humans; Phenytoi

1998
Increased bFGF level in the serum of patients with phenytoin-induced gingival overgrowth.
    Journal of clinical periodontology, 1998, Volume: 25, Issue:1

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Chromatography, High Pressure Liquid; Enzyme

1998
Fetal hydantoin syndrome: an unusual cause of hip dysplasia.
    Orthopedics, 1998, Volume: 21, Issue:2

    Topics: Abnormalities, Drug-Induced; Acetabulum; Adult; Anticonvulsants; Epilepsy; Female; Hip Dislocation,

1998
[Optimisation of epilepsy monotherapy (clinico-pharmacological study)].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1997, Volume: 97, Issue:7

    Topics: Anticonvulsants; Barbiturates; Carbamazepine; Chromatography, High Pressure Liquid; Electroencephalo

1997
When the face tells the tale. Course facial features caused by phenytoin use.
    Postgraduate medicine, 1998, Volume: 103, Issue:3

    Topics: Anticonvulsants; Epilepsy; Facial Expression; Facies; Humans; Male; Middle Aged; Phenytoin

1998
Treatment of the epileptic patient in the dental office.
    The New York state dental journal, 1998, Volume: 64, Issue:2

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dental Care for Chronically Ill; Emergencies; Ep

1998
Interictal cardiovascular autonomic responses in patients with epilepsy.
    Epilepsia, 1998, Volume: 39, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Autonomic Nervous System; Blood Pressure; Epilepsy; Female; Hear

1998
Does antiepileptic therapy affect immune response?
    Journal of chemotherapy (Florence, Italy), 1998, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbama

1998
Comparison of anti-epileptic drug levels in different cases of sudden death.
    Journal of forensic sciences, 1998, Volume: 43, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Cause of Death; Child; Child, Preschool

1998
Postmortem changes in blood concentrations of phenytoin and carbamazepine: an experimental study.
    Therapeutic drug monitoring, 1998, Volume: 20, Issue:3

    Topics: Animals; Anticonvulsants; Carbamazepine; Death, Sudden; Epilepsy; Humans; Phenytoin; Postmortem Chan

1998
Antiepileptic drugs in developing countries.
    Lancet (London, England), 1998, Apr-18, Volume: 351, Issue:9110

    Topics: Anticonvulsants; Child; Clinical Trials as Topic; Developing Countries; Epilepsy; Humans; India; Phe

1998
Antiepileptic drugs in developing countries.
    Lancet (London, England), 1998, Jun-27, Volume: 351, Issue:9120

    Topics: Anticonvulsants; Developing Countries; Drug Utilization; Epilepsy; Humans; Phenobarbital; Phenytoin

1998
Changes in arrhythmia profile and heart rate variability during abrupt withdrawal of antiepileptic drugs. Implications for sudden death.
    Seizure, 1997, Volume: 6, Issue:5

    Topics: Adult; Aged; Analysis of Variance; Anticonvulsants; Arrhythmias, Cardiac; Autonomic Nervous System;

1997
Benefits of a clinical pharmacokinetic service in optimising phenytoin use in the western Cape.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1998, Volume: 88, Issue:7

    Topics: Ambulatory Care Facilities; Anticonvulsants; Epilepsy; Humans; Patient Compliance; Phenytoin; Referr

1998
Age-dependent phenytoin effects on cortical stimulation in rats.
    Physiological research, 1998, Volume: 47, Issue:2

    Topics: Age Factors; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Electric Stimulation

1998
Limbic epileptogenesis alters the anticonvulsant efficacy of phenytoin in Sprague-Dawley rats.
    Epilepsy research, 1998, Volume: 31, Issue:3

    Topics: Amygdala; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsy

1998
Peripheral benzodiazepine receptor expression on leukocytes and neutrophil function during anticonvulsant monotherapy.
    Pharmacology, 1998, Volume: 57, Issue:4

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Leukocytes; Lymph

1998
Antiepileptic drug use in nursing home residents: effect of age, gender, and comedication on patterns of use.
    Epilepsia, 1998, Volume: 39, Issue:10

    Topics: Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carb

1998
Intravenous phenytoin: cheap but not necessarily a bargain.
    Neurology, 1998, Volume: 51, Issue:4

    Topics: Anticonvulsants; Drug Costs; Epilepsy; Humans; Injections, Intravenous; Phenytoin

1998
Pharmacoeconomic considerations in treatment options for acute seizures.
    Journal of child neurology, 1998, Volume: 13 Suppl 1

    Topics: Anticonvulsants; Child; Child, Preschool; Cost-Benefit Analysis; Diazepam; Economics, Pharmaceutical

1998
Allergic hypersensitivity to antiepileptic drugs: past, present, and future.
    Epilepsia, 1998, Volume: 39 Suppl 7

    Topics: Anticonvulsants; Child; Drug Hypersensitivity; Epilepsy; Forecasting; Germany; History, 20th Century

1998
Quantifying the costs of serious adverse drug reactions to antiepileptic drugs.
    Epilepsia, 1998, Volume: 39 Suppl 7

    Topics: Adolescent; Adult; Anticonvulsants; Direct Service Costs; Drug Costs; Drug Hypersensitivity; Epileps

1998
Selection of phenytoin responders and nonresponders in male and female amygdala-kindled Sprague-Dawley rats.
    Epilepsia, 1998, Volume: 39, Issue:11

    Topics: Amygdala; Animals; Anticonvulsants; Drug Resistance; Epilepsy; Female; Kindling, Neurologic; Male; P

1998
Paroxysmal kinesigenic choreoathetosis in Singapore and its relationship to epilepsy.
    Clinical neurology and neurosurgery, 1998, Volume: 100, Issue:3

    Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Athetosis; Carbamazepine; Child; Chorea; Comorbidi

1998
[Serum lipids. lipoproteins, and apolipoproteins in adult epileptics treated with carbamazepine, valproic acid, or phenytoin].
    Revista de neurologia, 1998, Volume: 27, Issue:159

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Apolipoproteins; Carbamazepine; Cholesterol; Choles

1998
The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics.
    Epilepsia, 1998, Volume: 39, Issue:12

    Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 E

1998
A study of the pharmacokinetics of phenytoin (diphenylhydantoin) in epileptic patients, and the development of a nomogram for making dose increments.
    Epilepsia, 1975, Volume: 16, Issue:4

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Biological Availability; Clinical Pharmacy Information Sys

1975
Comparison between premortem and postmortem serum concentrations of phenobarbital, phenytoin, carbamazepine and its 10,11-epoxide metabolite in institutionalized patients with epilepsy.
    Epilepsy research, 1999, Volume: 33, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Hospitalization; H

1999
Factors influencing the population pharmacokinetic parameters of phenytoin in adult epileptic patients in South Africa.
    Therapeutic drug monitoring, 1999, Volume: 21, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alcohol Drinking; Amino Acid Sequence; Anti

1999
Phenytoin-associated thrombocytopenia in a toddler.
    Journal of child neurology, 1999, Volume: 14, Issue:2

    Topics: Anticonvulsants; Child, Preschool; Dandy-Walker Syndrome; Epilepsy; Female; Humans; Phenytoin; Throm

1999
Determination of phenytoin in sections of head hair: a preliminary study to evaluate the history of drug use.
    Bollettino chimico farmaceutico, 1998, Volume: 137, Issue:11

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Chromatography, High Pressure Liquid; Epilepsy; Fem

1998
Allergic skin reactions to anticonvulsant medications in patients receiving cranial radiation therapy.
    Epilepsia, 1999, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Astrocytoma; Brain Neoplasms; Drug Eruptions; Drug Therapy

1999
Elevated plasma concentrations of homocysteine in antiepileptic drug treatment.
    Epilepsia, 1999, Volume: 40, Issue:3

    Topics: Age Factors; Ambulatory Care; Anticonvulsants; Carbamazepine; Convulsants; Depression, Chemical; Epi

1999
Bone mineral density of epileptic patients on long-term antiepileptic drug therapy: a quantitative digital radiography study.
    Epilepsy research, 1999, Volume: 33, Issue:2-3

    Topics: Absorptiometry, Photon; Acetazolamide; Adult; Anticonvulsants; Barbiturates; Bone Density; Epilepsy;

1999
Anticonvulsant and neurotoxic effects of intracerebroventricular injection of phenytoin, phenobarbital and carbamazepine in an amygdala-kindling model of epilepsy in the rat.
    Epilepsy research, 1999, Volume: 33, Issue:2-3

    Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Injec

1999
Systemic vasculitis associated with long-term phenytoin therapy.
    The New Zealand medical journal, 1999, Mar-26, Volume: 112, Issue:1084

    Topics: Antibodies, Antinuclear; Anticonvulsants; Biopsy; Chronic Disease; Epilepsy; Humans; Male; Middle Ag

1999
Phenytoin dosage adjustment in Saudi epileptics: utilization of steady-state pharmacokinetic parameters.
    European journal of neurology, 1999, Volume: 6, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Child; Child, Preschool; Chromatography, Hi

1999
Anticonvulsant hypersensitivity syndrome with an epoxide hydrolase defect.
    The British journal of dermatology, 1999, Volume: 140, Issue:1

    Topics: Anticonvulsants; Drug Hypersensitivity; Epilepsy; Humans; Male; Middle Aged; Neurocysticercosis; Phe

1999
Landau Kleffner syndrome.
    Indian pediatrics, 1998, Volume: 35, Issue:9

    Topics: Adolescent; Anticonvulsants; Clonazepam; Epilepsy; GABA Modulators; Humans; Hyperkinesis; Landau-Kle

1998
Changes in phenytoin concentrations in blood and cerebrospinal fluid caused by direct hemoperfusion in a patient intoxicated with phenytoin.
    Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis, 1998, Volume: 2, Issue:1

    Topics: Acute Disease; Anticonvulsants; Drug Monitoring; Epilepsy; Female; Hemoperfusion; Humans; Metabolic

1998
Atrioventricular septal defect with separate right and left atrioventricular valvar orifices in a patient with foetal hydantoin syndrome.
    Cardiology in the young, 1999, Volume: 9, Issue:1

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cardiac Catheterization; Echocardiography, Doppler; Ep

1999
[Residual cerebellar ataxia following acute phenytoin intoxication].
    Revue neurologique, 1999, Volume: 155, Issue:4

    Topics: Adult; Anticonvulsants; Atrophy; Brain; Brain Neoplasms; Cerebellar Ataxia; Cerebellum; Epilepsy; Hu

1999
Temperature effect on serum protein binding kinetics of phenytoin in monotherapy patients with epilepsy.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 1999, Volume: 47, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Blood Proteins; Child; Child, Preschool; Epilepsy; Female; Human

1999
Phenytoin metabolism to 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) in man, cat and rat in vitro and in vivo, and susceptibility to phenytoin-induced gingival overgrowth.
    Journal of periodontal research, 1999, Volume: 34, Issue:3

    Topics: Adult; Aged; Animals; Anticonvulsants; Area Under Curve; Biotransformation; Cats; Chlorophyll; Chrom

1999
Efficacy of statin therapy: possible effect of phenytoin.
    Postgraduate medical journal, 1999, Volume: 75, Issue:884

    Topics: Anticholesteremic Agents; Atorvastatin; Cytochrome P-450 Enzyme System; Drug Interactions; Epilepsy;

1999
Paradoxical seizures in phenytoin toxicity.
    Singapore medical journal, 1999, Volume: 40, Issue:4

    Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Middle Age

1999
Malformations in offspring of women with epilepsy: a prospective study.
    Epilepsia, 1999, Volume: 40, Issue:9

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Comorbidity; Congenital Abnormalities;

1999
Problem of managing patients with epilepsy in developing countries.
    Epilepsia, 1999, Volume: 40, Issue:10

    Topics: Anticonvulsants; Carbamazepine; Cost-Benefit Analysis; Developing Countries; Drug Costs; Economics,

1999
Clinical experience with new antiepileptic drugs: antiepileptic drugs in Europe.
    Epilepsia, 1999, Volume: 40 Suppl 6

    Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Cross-Cultural Comparison; Drug Approval;

1999
Reversible total IgA deficiency associated with phenytoin treatment.
    Scandinavian journal of infectious diseases, 1999, Volume: 31, Issue:5

    Topics: Anticonvulsants; Epilepsy; Humans; IgA Deficiency; Lung Diseases; Male; Middle Aged; Phenytoin

1999
Subtherapeutic levels of phenytoin with standard doses in infants: need to review dosage schedule.
    British journal of clinical pharmacology, 1999, Volume: 48, Issue:3

    Topics: Anticonvulsants; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Epilepsy;

1999
Practical management of therapeutic diphenylhydantoin concentrations in children.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1999, Volume: 89, Issue:10

    Topics: Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Monitoring; Epileps

1999
The effect of multiple anticonvulsant therapy on the expression of phenytoin-induced gingival overgrowth.
    Journal of clinical periodontology, 1999, Volume: 26, Issue:12

    Topics: Adult; Anticonvulsants; Chromatography, High Pressure Liquid; Drug Interactions; Drug Therapy, Combi

1999
Postoperative anticonvulsant prophylaxis for patients treated for cerebral aneurysms.
    Neurologia medico-chirurgica, 1999, Volume: 39, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Craniotomy; Drug Administration Schedule; Epilepsy;

1999
In vivo binding characteristics of phenytoin to serum proteins in monotherapy pediatric patients with epilepsy.
    International journal of clinical pharmacology and therapeutics, 2000, Volume: 38, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Blood Proteins; Child; Child, Preschool; Epilepsy; Female; Human

2000
[Anesthetic management of a patient with West syndrome].
    Masui. The Japanese journal of anesthesiology, 2000, Volume: 49, Issue:1

    Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Anticonvulsants; Epilepsy; Female; Hordeol

2000
Elimination of phenytoin in toxic overdose.
    Clinical neurology and neurosurgery, 2000, Volume: 102, Issue:1

    Topics: Adult; Aged; Anticonvulsants; Drug Overdose; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin;

2000
Onset and duration of action of rocuronium in children receiving chronic anticonvulsant therapy.
    Paediatric anaesthesia, 2000, Volume: 10, Issue:2

    Topics: Analysis of Variance; Androstanols; Anesthesia Recovery Period; Anticonvulsants; Carbamazepine; Case

2000
Phenytoin as the first option in female epileptic patients?
    Arquivos de neuro-psiquiatria, 1999, Volume: 57, Issue:3B

    Topics: Acne Vulgaris; Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Follow-Up Studies; Gingival Hyp

1999
[Dupuytren's and Ledderhose's diseases associated with chronic use of anticonvulsants. Case report].
    Arquivos de neuro-psiquiatria, 1999, Volume: 57, Issue:3B

    Topics: Adult; Anticonvulsants; Diazepam; Dupuytren Contracture; Epilepsy; Foot Diseases; Humans; Male; Phen

1999
Anticonvulsant efficacy of topiramate in phenytoin-resistant kindled rats.
    Epilepsia, 2000, Volume: 41, Issue:4

    Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Drug Resistance; Electric Stimulation; E

2000
Phenytoin administration in the newborn and infant.
    Brain & development, 2000, Volume: 22, Issue:1

    Topics: Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Infant; Infant, Newborn; Male; Phenytoi

2000
Effects of topiramate on sustained repetitive firing and spontaneous recurrent seizure discharges in cultured hippocampal neurons.
    Epilepsia, 2000, Volume: 41, Issue:S1

    Topics: Action Potentials; Animals; Anticonvulsants; Calcium Channels; Cells, Cultured; Dose-Response Relati

2000
Homocysteine concentrations and methionine loading in patients on antiepileptic drugs.
    Acta neurologica Scandinavica, 2000, Volume: 101, Issue:4

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Cytochrome P-450 Enzyme System; E

2000
Kindling alters the anticonvulsant efficacy of phenytoin in Wistar rats.
    Epilepsy research, 2000, Volume: 39, Issue:3

    Topics: Amygdala; Animals; Anticonvulsants; Electric Stimulation; Electrodes, Implanted; Epilepsy; Female; I

2000
Changes in bone turnover and deoxypyridinoline levels in epileptic patients.
    Clinical chemistry and laboratory medicine, 2000, Volume: 38, Issue:1

    Topics: Adult; Alkaline Phosphatase; Amino Acids; Anticonvulsants; Bone and Bones; Calcium; Carbamazepine; C

2000
[Drug resistant epilepsy in Senegal: therapeutic, clinical and socioeconomic factors].
    Dakar medical, 1999, Volume: 44, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Resistance; Epilepsy; Female; Humans;

1999
[Phenytoin-induced hypersensitivity reaction with liver failure].
    Praxis, 2000, Apr-13, Volume: 89, Issue:16

    Topics: Anticonvulsants; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Administration Sche

2000
Seizure-inducing paradoxical reaction to antiepileptic drugs.
    Brain & development, 2000, Volume: 22, Issue:4

    Topics: Anticonvulsants; Clonazepam; Drug Therapy, Combination; Electroencephalography; Epilepsy; Female; Hu

2000
[Dose-dependent relationship of chronic use of phenytoin and cerebellar atrophy in patients with epilepsy].
    Arquivos de neuro-psiquiatria, 2000, Volume: 58, Issue:2A

    Topics: Adult; Anticonvulsants; Atrophy; Cerebellum; Dose-Response Relationship, Drug; Epilepsy; Female; Hum

2000
Validation of population pharmacokinetic parameters of phenytoin using the parallel Michaelis-Menten and first-order elimination model.
    Therapeutic drug monitoring, 2000, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Data Interpretation, Statistical; Dose-

2000
Association of prenatal phenobarbital and phenytoin exposure with small head size at birth and with learning problems.
    Acta paediatrica (Oslo, Norway : 1992), 2000, Volume: 89, Issue:5

    Topics: Adult; Anticonvulsants; Cephalometry; Cognition; Cross-Sectional Studies; Epilepsy; Female; Follow-U

2000
A story of "Ayurvedic" tablets and misled epileptic patients.
    The Journal of the Association of Physicians of India, 1999, Volume: 47, Issue:11

    Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epi

1999
Absence of pharmacokinetic drug interaction of levetiracetam with phenytoin in patients with epilepsy determined by new technique.
    Journal of clinical pharmacology, 2000, Volume: 40, Issue:6

    Topics: Adult; Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Levetiraceta

2000
Plasma total glutathione concentrations in epileptic patients taking anticonvulsants.
    Clinica chimica acta; international journal of clinical chemistry, 2000, Volume: 298, Issue:1-2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cysteine; Epilepsy; Glutathione; Humans; Oxidatio

2000
A clinical study of 57 children with fetal anticonvulsant syndromes.
    Journal of medical genetics, 2000, Volume: 37, Issue:7

    Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep

2000
An unresponsive patient with a history of stroke.
    Hospital practice (1995), 1999, Oct-15, Volume: 34, Issue:11

    Topics: Aged; Anticonvulsants; Diagnosis, Differential; Drug Overdose; Epilepsy; Female; Humans; Phenytoin;

1999
[Cerebellar damage caused by phenytoin intoxication].
    Duodecim; laaketieteellinen aikakauskirja, 1997, Volume: 113, Issue:22

    Topics: Adolescent; Anticonvulsants; Cerebellar Ataxia; Drug Monitoring; Epilepsy; Female; Humans; Phenytoin

1997
[Progressive, small spotted, confluent erythema with bullae formation and general symptoms. Acute Lyell syndrome].
    Praxis, 2000, Jun-08, Volume: 89, Issue:23

    Topics: Adult; Anticonvulsants; Diagnosis, Differential; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; S

2000
Effect of sex on serum protein binding characteristics of phenytoin in pediatric patients with epilepsy.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2000, Jun-15, Volume: 57, Issue:12

    Topics: Adolescent; Anticonvulsants; Blood Proteins; Child; Child, Preschool; Epilepsy; Female; Fluorescence

2000
Bone mineral density, vitamin D and anticonvulsant therapy.
    Arquivos de neuro-psiquiatria, 2000, Volume: 58, Issue:3A

    Topics: Adult; Anticonvulsants; Bone Density; Case-Control Studies; Epilepsy; Humans; Male; Phenobarbital; P

2000
Epilepsy.
    Neurobiology of disease, 2000, Volume: 7, Issue:5

    Topics: Animals; Anticonvulsants; Electrophysiology; Epilepsy; Humans; Mutation; Neurons; Phenytoin; Seizure

2000
Effects of combined administration of zonisamide and valproic acid or phenytoin to nitric oxide production, monoamines and zonisamide concentrations in the brain of seizure-susceptible EL mice.
    Brain research bulletin, 2000, Sep-15, Volume: 53, Issue:2

    Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Interactions; Dru

2000
Purple glove syndrome caused by oral administration of phenytoin.
    Journal of child neurology, 2000, Volume: 15, Issue:11

    Topics: Administration, Oral; Anticonvulsants; Child; Drug Overdose; Edema; Epilepsy; Extremities; Humans; M

2000
[Prodilantin: a new antiepileptic?].
    Presse medicale (Paris, France : 1983), 2000, Nov-25, Volume: 29, Issue:36

    Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; Humans; Phenytoin; Treatment Outcome

2000
I. The modulatory effect in genotoxic responses due to age and duration of PHT-therapy in epileptic patients.
    Teratogenesis, carcinogenesis, and mutagenesis, 2001, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Age Factors; Age of Onset; Anticonvulsants; Child; Epilepsy; Female; Humans; Lymp

2001
II. An altered proliferation response due to the anticonvulsant phenytoin (PHT) in epileptic patients.
    Teratogenesis, carcinogenesis, and mutagenesis, 2001, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Age Factors; Age of Onset; Anticonvulsants; Cell Cycle; Cell Division; Child; Epi

2001
The teratogenicity of anticonvulsant drugs.
    The New England journal of medicine, 2001, Apr-12, Volume: 344, Issue:15

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Case-Control Studies; Congenital Abnorm

2001
In vivo binding characteristics of phenytoin to serum proteins in monotherapy for adults with epilepsy.
    American journal of therapeutics, 2000, Volume: 7, Issue:6

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Blood Proteins; Epilepsy; Female; Humans; Kinetics; Male;

2000
No gender effect on binding characteristics of phenytoin to serum proteins in monotherapy for adult patients with epilepsy.
    American journal of therapeutics, 2000, Volume: 7, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Sex

2000
Antiepileptic drug therapy and its management in sudden unexpected death in epilepsy: a case-control study.
    Epilepsia, 2001, Volume: 42, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Cohort Studies; Death, Sudd

2001
Effect of temperature on serum protein binding characteristics of phenytoin in monotherapy paediatric patients with epilepsy.
    Journal of clinical pharmacy and therapeutics, 2001, Volume: 26, Issue:3

    Topics: Adolescent; Anticonvulsants; Blood Proteins; Child; Child, Preschool; Epilepsy; Female; Humans; Infa

2001
[Reversible phenytoin-induced extrapontine myelinolysis].
    Der Nervenarzt, 2001, Volume: 72, Issue:6

    Topics: Adult; Epilepsy; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Myelinolysis, Centra

2001
Seizures at high altitude in a patient on antiseizure medications.
    Wilderness & environmental medicine, 2001,Summer, Volume: 12, Issue:2

    Topics: Anticonvulsants; Epilepsy; Humans; Male; Middle Aged; Mountaineering; Phenytoin; Seizures

2001
The effect of genetic polymorphism of cytochrome P450 CYP2C9 on phenytoin dose requirement.
    Pharmacogenetics, 2001, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Aged; Alleles; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 C

2001
Induction of hypersensitivity to a previously tolerated antiepileptic drug by a second antiepileptic drug.
    Epilepsia, 2001, Volume: 42, Issue:3

    Topics: Adult; Anticonvulsants; Carbamazepine; Cross Reactions; Drug Eruptions; Drug Hypersensitivity; Drug

2001
Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain.
    Neuroreport, 2001, Aug-08, Volume: 12, Issue:11

    Topics: Animals; Anticonvulsants; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Drug Resist

2001
Epilepsy.
    The New England journal of medicine, 2001, Aug-09, Volume: 345, Issue:6

    Topics: Anticonvulsants; Automobile Driving; Epilepsy; Female; Guidelines as Topic; Humans; Phenytoin; Valpr

2001
Genetic polymorphisms and functional characterization of the 5'-flanking region of the human CYP2C9 gene: in vitro and in vivo studies.
    Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:2

    Topics: Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Bayes Theorem; Cytochrome P-450 CYP2C9; Cytoc

2001
Are serum anticonvulsant levels in people with epilepsy appropriately monitored?
    Journal of evaluation in clinical practice, 2001, Volume: 7, Issue:3

    Topics: Anticonvulsants; Drug Monitoring; Epilepsy; Humans; Logistic Models; Phenytoin; Valproic Acid

2001
Dietary iron reduces the anti-convulsion activity of phenytoin in electroconvulsion via inhibition of brain penetration.
    Brain research, 2001, Oct-05, Volume: 915, Issue:1

    Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Dose-Response Relationship, Drug; Drug Interac

2001
Prevalence and risk of gingival enlargement in patients treated with anticonvulsant drugs.
    European journal of clinical investigation, 2001, Volume: 31, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Anticonvulsants; Cross-Sectional Studi

2001
[Analogs of generic preparations for the treatment of epilepsy: is their use safe?].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2001, Volume: 101, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Child, Preschool;

2001
Effects of antiepileptic drugs on afterdischarge generation in rat hippocampal slices.
    Brain research, 2002, Jan-04, Volume: 924, Issue:1

    Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Bicuculline; Carbamazepine; Dose-Respo

2002
Intravenous diphenylhydantoin in treatment of acute repetitive seizures. 1968.
    Neurology, 2001, Volume: 57, Issue:11 Suppl 4

    Topics: Acute Disease; Anticonvulsants; Epilepsy; History, 20th Century; Humans; Infusions, Intravenous; Phe

2001
Anticonvulsants-induced chorea: a role for pharmacodynamic drug interaction?
    Seizure, 2001, Volume: 10, Issue:8

    Topics: Anticonvulsants; Child, Preschool; Chorea; Drug Synergism; Drug Therapy, Combination; Dyskinesia, Dr

2001
An algorithm for monitoring phenytoin therapy.
    Journal of the American Academy of Nurse Practitioners, 2000, Volume: 12, Issue:8

    Topics: Algorithms; Anticonvulsants; Epilepsy; Evidence-Based Medicine; Humans; Nurse Practitioners; Phenyto

2000
Ophthalmic findings in fetal anticonvulsant syndrome(s).
    Ophthalmology, 2002, Volume: 109, Issue:5

    Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep

2002
Fatal case of accidental intra-arterial phenytoin injection.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2002, Volume: 23, Issue:4

    Topics: Accidents; Aged; Aged, 80 and over; Anticonvulsants; Arm; Epilepsy; Fatal Outcome; Female; Gangrene;

2002
How high can we go with phenytoin?
    Therapeutic drug monitoring, 2002, Volume: 24, Issue:3

    Topics: Anticonvulsants; Child; Child, Hospitalized; Drug Monitoring; Epilepsy; Female; Glasgow Coma Scale;

2002
Topiramate and phenytoin pharmacokinetics during repetitive monotherapy and combination therapy to epileptic patients.
    Epilepsia, 2002, Volume: 43, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochr

2002
[Adverse effects of anti-epileptic drugs].
    Deutsche medizinische Wochenschrift (1946), 1975, Sep-19, Volume: 100, Issue:38

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethos

1975
Prognosis and therapy of complex partial seizures with barbiturates, hydantoins, and other drugs.
    Advances in neurology, 1975, Volume: 11

    Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Drug Therapy, Combination; Epilepsy; Epilepsy, Tempo

1975
Activity of gamma-glutamyl transpeptidase in serum of patients receiving anticonvulsant of anticoagulant therapy.
    Clinical biochemistry, 1976, Volume: 9, Issue:2

    Topics: Alkaline Phosphatase; Anticoagulants; Anticonvulsants; Aspartate Aminotransferases; Epilepsy; gamma-

1976
Resistant transitory epilepsy in children.
    Acta neurologica Scandinavica, 1976, Volume: 53, Issue:2

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Carbamazepine; Child, Preschool; Encephalomyelitis, Ac

1976
[Determination of phenobarbital, mephenytoin and diphenylhydantoin in the surveillance of anticonvulsant treatment].
    Annales de biologie clinique, 1976, Volume: 34, Issue:2

    Topics: Barbiturates; Child; Chromatography, Gas; Epilepsy; Ether; Humans; Hydantoins; Mephenytoin; Methylat

1976
Anticonvulsant therapy and serum gamma-glutamyl-transferase.
    Klinische Wochenschrift, 1978, Sep-15, Volume: 56, Issue:18

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Epilepsy; Female; gamma-Glutamyltran

1978
Use of anticonvulsant drugs.
    JAMA, 1979, Feb-09, Volume: 241, Issue:6

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Epilepsy; Ethosuximide; Humans; Phenobarbital

1979
Neuropsychological correlates of anticonvulsants and epileptiform discharges in adult epileptics.
    Electroencephalography and clinical neurophysiology. Supplement, 1978, Issue:34

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy; Humans; Phenyto

1978
Amines, anticonvulsants, and epilepsy.
    Lancet (London, England), 1975, Mar-01, Volume: 1, Issue:7905

    Topics: Adolescent; Adult; Anticonvulsants; Brain; Chromatography, Gas; Drug Therapy, Combination; Epilepsy;

1975
Letter: Bioavailability of drugs after intramuscular injection.
    Lancet (London, England), 1975, Mar-22, Volume: 1, Issue:7908

    Topics: Absorption; Administration, Oral; Adult; Biological Availability; Biotransformation; Carbamazepine;

1975
Letter: Amines, anticonvulsants, and epilepsy.
    Lancet (London, England), 1975, Mar-15, Volume: 1, Issue:7907

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Humans; Hydroxyindoleacetic Ac

1975
[Anticonvulsant drugs and liver damage (Author's transl)].
    Journal of neurology, 1975, Volume: 208, Issue:3

    Topics: Adult; Anticonvulsants; Antitubercular Agents; Autopsy; Chemical and Drug Induced Liver Injury; Chol

1975
Letter: Amines, anticonvulsants, and epilepsy.
    Lancet (London, England), 1975, Jun-28, Volume: 1, Issue:7922

    Topics: Animals; Anticonvulsants; Brain; Epilepsy; Humans; Phenobarbital; Phenytoin; Rats; Serotonin

1975
Letter: Word reversal during phenytoin therapy.
    Lancet (London, England), 1975, Jul-19, Volume: 2, Issue:7925

    Topics: Adult; Aphasia; Epilepsy; Female; Humans; Phenytoin

1975
Serum-phenytoin levels in management of epilepsy.
    Lancet (London, England), 1975, Aug-09, Volume: 2, Issue:7928

    Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy; Humans; Phenytoin; Time Fa

1975
Editorial: Drug levels in epilepsy.
    Lancet (London, England), 1975, Aug-09, Volume: 2, Issue:7928

    Topics: Adult; Biological Availability; Child; Dose-Response Relationship, Drug; Drug Tolerance; Epilepsy; H

1975
Letter: Phenytoin dosage.
    Lancet (London, England), 1975, Aug-09, Volume: 2, Issue:7928

    Topics: Biological Availability; Dose-Response Relationship, Drug; Epilepsy; Humans; Phenytoin

1975
EEG changes after withdrawal of medication in epileptic patients.
    Electroencephalography and clinical neurophysiology, 1975, Volume: 39, Issue:2

    Topics: Adult; Anticonvulsants; Brain; Electroencephalography; Epilepsy; Humans; Phenobarbital; Phenytoin; P

1975
The effect of phenytoin and ethosuximide on primidone metabolism in patients with epilepsy.
    Journal of neurology, 1975, Jun-09, Volume: 209, Issue:2

    Topics: Drug Interactions; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Humans; Male; Phenobar

1975
Letter: Drug levels in epilepsy.
    Lancet (London, England), 1975, Sep-13, Volume: 2, Issue:7933

    Topics: Epilepsy; Humans; Phenytoin

1975
Proceedings: Influence of a single intravenous dose of phenytoin on to EEG.
    Electroencephalography and clinical neurophysiology, 1975, Volume: 39, Issue:4

    Topics: Adult; Child; Electroencephalography; Epilepsy; Humans; Injections, Intravenous; Phenytoin

1975
IgA deficiency, epilepsy, and phenytoin treatment.
    Lancet (London, England), 1975, Oct-04, Volume: 2, Issue:7936

    Topics: Adolescent; Cell Membrane; Child; Child, Preschool; Epilepsy; Female; Humans; IgA Deficiency; Immuno

1975
Letter: Phenytoin dosage nomogram.
    Lancet (London, England), 1975, Dec-27, Volume: 2, Issue:7948

    Topics: Epilepsy; Follow-Up Studies; Humans; Phenytoin; Retrospective Studies

1975
Letter: Pyridoxine and serum concentration of phenytoin and phenobarbitone.
    Lancet (London, England), 1976, Jan-31, Volume: 1, Issue:7953

    Topics: Child; Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Pyridoxine; Time Factors

1976
Anticonvulsants and parental epilepsy in the development of birth defects.
    Lancet (London, England), 1976, Feb-07, Volume: 1, Issue:7954

    Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Epilepsy; Female; Finland; Follow-Up Studies;

1976
Letter: Serum-phenytoin and body-weight.
    Lancet (London, England), 1976, Apr-10, Volume: 1, Issue:7963

    Topics: Adult; Body Weight; Dose-Response Relationship, Drug; Epilepsy; Humans; Male; Phenytoin

1976
Letter: Immunosuppression by phenytoin.
    Lancet (London, England), 1976, Apr-17, Volume: 1, Issue:7964

    Topics: Child, Preschool; Dysgammaglobulinemia; Epilepsy; Humans; Immunoglobulin A; Immunologic Deficiency S

1976
Letter: Immunodeficiency and epilepsy.
    Lancet (London, England), 1976, Apr-17, Volume: 1, Issue:7964

    Topics: Adolescent; Adult; Agammaglobulinemia; Autoimmune Diseases; Child; Dysgammaglobulinemia; Epilepsy; H

1976
Letter: Anticonvulsants and fetal malformations.
    Lancet (London, England), 1976, May-01, Volume: 1, Issue:7966

    Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Phenobarbital; Phenytoin; Pr

1976
Letter: Lymphocyte-count in children treated with phenytoin.
    Lancet (London, England), 1976, Jul-03, Volume: 2, Issue:7975

    Topics: Adolescent; Age Factors; Child; Child, Preschool; Epilepsy; Humans; Leukocyte Count; Lymphocytes; Ph

1976
Letter: One drug (phenytoin) in treatment of epilepsy.
    Lancet (London, England), 1976, Jul-17, Volume: 2, Issue:7977

    Topics: Drug Interactions; Epilepsy; Humans; Phenytoin

1976
Salivary concentrations of antiepileptic drugs.
    Lancet (London, England), 1976, Sep-18, Volume: 2, Issue:7986

    Topics: Epilepsy; Humans; Methods; Parotid Gland; Phenytoin; Saliva

1976
VACTERL congenital malformation and phenytoin therapy.
    Lancet (London, England), 1976, Oct-30, Volume: 2, Issue:7992

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Epilepsy; Female; Humans; Infant,

1976
Lymphocytes in children treated with phenytoin.
    Lancet (London, England), 1976, Nov-27, Volume: 2, Issue:7996

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Infant; Leukocyte Count; Lymphocytes; Phenyto

1976
Valproate may lower serum-phenytoin.
    Lancet (London, England), 1976, Dec-11, Volume: 2, Issue:7998

    Topics: Drug Interactions; Epilepsy; Humans; Phenytoin; Valerates; Valproic Acid

1976
How doctors deal with epilepsy.
    Lancet (London, England), 1977, Jan-22, Volume: 1, Issue:8004

    Topics: Adolescent; Adult; Aged; Automobile Driving; Diazepam; Drug Therapy, Combination; Electroencephalogr

1977
Serum-phenytoin, seizures, and electroencephalography.
    Lancet (London, England), 1977, Apr-16, Volume: 1, Issue:8016

    Topics: Electroencephalography; Epilepsy; Humans; Phenytoin; Retrospective Studies

1977
Salivary phenytoin concentrations in epilepsy and in chronic renal failure.
    Lancet (London, England), 1976, Aug-21, Volume: 2, Issue:7982

    Topics: Adolescent; Adult; Biological Availability; Child; Child, Preschool; Epilepsy; Female; Humans; Kidne

1976
Therapeutic and pharmacokinetic effects of increasing phenytoin in chronic epileptics on multiple drug therapy.
    Lancet (London, England), 1976, Aug-21, Volume: 2, Issue:7982

    Topics: Adult; Biological Availability; Chronic Disease; Dose-Response Relationship, Drug; Drug Therapy, Com

1976
In vivo interaction of anticonvulsant drugs. The mathematical correlation of plasma levels of anticonvulsant drugs in epileptic patients.
    Journal of neurology, 1978, May-18, Volume: 218, Issue:2

    Topics: Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; In

1978
Haematological effects of anticonvulsant treatment.
    Lancet (London, England), 1978, Aug-05, Volume: 2, Issue:8084

    Topics: Anemia, Macrocytic; Epilepsy; Female; Humans; Male; Phenytoin

1978
Haematological effects of anticonvulsant treatment.
    Lancet (London, England), 1978, Sep-23, Volume: 2, Issue:8091

    Topics: Drug Therapy, Combination; Epilepsy; Erythrocyte Volume; Erythrocytes, Abnormal; Humans; Phenytoin;

1978
Effects of anticonvulsant drugs on thyroid hormones in epileptic children.
    Epilepsia, 1978, Volume: 19, Issue:4

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Cholesterol; Dose-Response Relationship, Drug; Dr

1978
Coefficient of variation as measure of compliance.
    Lancet (London, England), 1978, Oct-14, Volume: 2, Issue:8094

    Topics: Analysis of Variance; Epilepsy; Humans; Patient Compliance; Phenytoin

1978
Anticonvulsant drugs and cancer. A cohort study in patients with severe epilepsy.
    Lancet (London, England), 1979, Sep-01, Volume: 2, Issue:8140

    Topics: Adolescent; Adult; Brain Neoplasms; Child; England; Epilepsy; Female; Follow-Up Studies; Humans; Mal

1979
Epilepsy in childhood.
    The New Zealand medical journal, 1978, Nov-22, Volume: 88, Issue:624

    Topics: Anticonvulsants; Child; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Humans; Infant; Infant,

1978
Effect of carbamazepine, phenytoin and phenobarbitone on serum levels of thyroid hormones and thyrotropin in humans.
    Scandinavian journal of clinical and laboratory investigation, 1978, Volume: 38, Issue:8

    Topics: Adult; Carbamazepine; Epilepsy; Humans; Phenobarbital; Phenytoin; Radioimmunoassay; Thyroid Hormones

1978
Bone morphology in epileptics.
    Calcified tissue international, 1979, Oct-31, Volume: 28, Issue:2

    Topics: Adult; Aged; Bone and Bones; Bone Diseases; Bone Resorption; Epilepsy; Female; Humans; Male; Middle

1979
Bone mineral content in epileptics.
    Calcified tissue international, 1979, Oct-31, Volume: 28, Issue:2

    Topics: Aged; Bone and Bones; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged; Minerals; Muscle C

1979
Childhood epilepsy uncontrolled by phenytoin: clinical and electroencephalographic study.
    Brain & development, 1979, Volume: 1, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy

1979
Valproic acid-phenytoin interaction.
    Therapeutic drug monitoring, 1979, Volume: 1, Issue:2

    Topics: Adult; Chromatography, Gas; Drug Interactions; Epilepsy; Humans; Monitoring, Physiologic; Phenytoin;

1979
Letter: Exfoliative dermatitis during treatment with pheneturide.
    British medical journal, 1975, Apr-19, Volume: 2, Issue:5963

    Topics: Adult; Anticonvulsants; Dermatitis, Exfoliative; Epilepsy; Humans; Male; Phenobarbital; Phenylbutyra

1975
Human epileptic brain Na, K ATPase activity and phenytoin concentrations.
    Archives of neurology, 1975, Volume: 32, Issue:8

    Topics: Acetylcholinesterase; Adenosine Triphosphatases; Adolescent; Adult; Astrocytes; Brain; Child; Epilep

1975
[Acne and phenytoin].
    Ugeskrift for laeger, 1977, Volume: 139, Issue:6

    Topics: Acne Vulgaris; Adult; Epilepsy; Female; Humans; Phenytoin; Time Factors

1977
[Phenytoin-induced acne].
    Ugeskrift for laeger, 1977, Feb-07, Volume: 139, Issue:6

    Topics: Acne Vulgaris; Adult; Cysts; Drug Eruptions; Drug Hypersensitivity; Epilepsy; Female; Humans; Phenyt

1977
Seizure activity and anticonvulsant drug concentration.
    Archives of neurology, 1975, Volume: 32, Issue:5

    Topics: Anticonvulsants; Child; Circadian Rhythm; Diazepam; Dose-Response Relationship, Drug; Drug Administr

1975
Patients with epilepsy.
    American family physician, 1975, Volume: 12, Issue:4

    Topics: Affective Symptoms; Age Factors; Alcoholism; Barbiturates; Child; Child, Preschool; Craniocerebral T

1975
Calcium and folic acid absorption in patients taking anticonvulsant drugs.
    The Journal of clinical endocrinology and metabolism, 1975, Volume: 41, Issue:06

    Topics: Adult; Aged; Calcium; Cholecalciferol; Epilepsy; Folic Acid; Humans; Male; Middle Aged; Osteomalacia

1975
Motor nerve conduction study in patients on diphenylhydantoin therapy.
    Journal of neurology, neurosurgery, and psychiatry, 1975, Volume: 38, Issue:12

    Topics: Adolescent; Adult; Epilepsy; Folic Acid; Humans; Male; Middle Aged; Motor Neurons; Neural Conduction

1975
[Hepatocellular adenoma].
    Ugeskrift for laeger, 1976, Jun-07, Volume: 138, Issue:24

    Topics: Abdomen; Adult; Carcinoma, Hepatocellular; Epilepsy; Hemorrhage; Humans; Liver Neoplasms; Male; Phen

1976
Prophylactic effects of phenytoin, phenobarbital, and carbamazepine examined in kindling cat preparations.
    Archives of neurology, 1976, Volume: 33, Issue:6

    Topics: Animals; Carbamazepine; Cats; Disease Models, Animal; Drug Evaluation, Preclinical; Electric Stimula

1976
Effects of diphenylhydantoin in 41 epileptics institutionalized since childhood.
    Southern medical journal, 1977, Volume: 70, Issue:1

    Topics: Adolescent; Adult; Alkaline Phosphatase; Anemia; Central Nervous System Diseases; Child; Epilepsy; F

1977
Reversible subacute peripheral neuropathy induced by phenytoin.
    Archives of neurology, 1977, Volume: 34, Issue:3

    Topics: Adult; Epilepsy; Female; Humans; Peripheral Nervous System Diseases; Phenytoin; Reflex, Abnormal

1977
[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome].
    Arquivos de neuro-psiquiatria, 1977, Volume: 35, Issue:3

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, Preschool; Clonazepam; Dia

1977
Increase of serum high-density lipoprotein in phenytoin users.
    British medical journal, 1978, Jul-08, Volume: 2, Issue:6130

    Topics: Adult; Apolipoproteins; Cholesterol; Epilepsy; Female; Humans; Lipoproteins, HDL; Male; Middle Aged;

1978
Elevation of high-density lipoprotein in epileptic patients treated with phenytoin.
    Acta medica Scandinavica, 1978, Volume: 204, Issue:6

    Topics: Adult; Cholesterol; Epilepsy; Female; Humans; Hypertrophy; Lipids; Lipoproteins; Lipoproteins, HDL;

1978
[Neurotransmission mechanisms underlying seizures and epilepsies (author's transl)].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1978, Volume: 23, Issue:13

    Topics: Acetylcholine; Amino Acids; Animals; Catecholamines; Electroencephalography; Epilepsy; Humans; Pheny

1978
Plasma high-density lipoproteins.
    The New England journal of medicine, 1979, Apr-05, Volume: 300, Issue:14

    Topics: Age Factors; Animals; Coronary Disease; Epilepsy; Female; Humans; Infant; Infant, Newborn; Lipoprote

1979
Drug interactions in epilepsy.
    Developmental medicine and child neurology, 1975, Volume: 17, Issue:1

    Topics: Anticonvulsants; Child; Depression, Chemical; Drug Interactions; Epilepsy; Humans; Phenytoin; Thiazi

1975
The drug management of acute behavioural disturbances.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1975, Apr-05, Volume: 49, Issue:15

    Topics: Acting Out; Acute Disease; Adrenergic beta-Antagonists; Aged; Antidepressive Agents, Tricyclic; Anti

1975
Plasma albumin concentration and diphenylhydantoin binding in man.
    Archives of neurology, 1975, Volume: 32, Issue:5

    Topics: Adolescent; Adult; Aged; Aspirin; Blood Protein Electrophoresis; Blood-Brain Barrier; Chromatography

1975
Involuntary movements caused by phenytoin intoxication in epileptic patients.
    Journal of neurology, neurosurgery, and psychiatry, 1975, Volume: 38, Issue:3

    Topics: Adult; Chlorpheniramine; Diazepam; Drug Interactions; Drug Therapy, Combination; Electroencephalogra

1975
[Effects of combination of anti-epileptic drugs].
    Bibliotheca psychiatrica, 1975, Issue:151

    Topics: Adrenergic beta-Antagonists; Anticonvulsants; Benzodiazepines; Carbamazepine; Digitoxin; Drug Intera

1975
Inhibition of phenytoin metabolism by other drugs used in epilepsy.
    International journal of clinical pharmacology and biopharmacy, 1975, Volume: 12, Issue:1-2

    Topics: Adult; Aged; Chloramphenicol; Chlorpromazine; Depression, Chemical; Drug Interactions; Epilepsy; Hal

1975
[Epilepsy--seizures are preventable].
    Schwestern Revue, 1979, Dec-15, Volume: 17, Issue:12

    Topics: Adult; Birth Injuries; Brain Damage, Chronic; Brain Injuries; Brain Neoplasms; Child; Epilepsy; Fema

1979
Diphenylhydantoin and pulmonary function.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1979, Volume: 6, Issue:1

    Topics: Adolescent; Adult; Epilepsy; Female; Humans; Male; Phenytoin; Respiration; Respiratory Function Test

1979
Dilantin and its relation to caries incidence.
    Dental hygiene, 1977, Volume: 51, Issue:8

    Topics: Adolescent; Adult; Dental Caries; Dental Health Surveys; DMF Index; Epilepsy; Female; Humans; Male;

1977
Diphenylhydantoinate-induced hyperplasia of the masticatory mucosa in an edentulous epileptic patient.
    Oral surgery, oral medicine, and oral pathology, 1978, Volume: 45, Issue:5

    Topics: Adult; Denture, Complete; Diagnosis, Differential; Epilepsy; Gingival Hyperplasia; Humans; Male; Mou

1978
Interrelationships between serum 25-hydroxycholecalciferol, serum parathyroid hormone and morphometric bone changes in anticonvulsant osteomalacia. Therapeutic effect of vitamin D2.
    Calcified tissue research, 1977, Volume: 22 Suppl

    Topics: Bone and Bones; Epilepsy; Ergocalciferols; Humans; Hydroxycholecalciferols; Ileum; Osteomalacia; Par

1977
Lymphocytotoxins in epileptic patients receiving phenytoin.
    Clinical and experimental immunology, 1977, Volume: 30, Issue:1

    Topics: Antibodies; Antibodies, Antinuclear; Epilepsy; Humans; Immunoglobulin M; Lupus Erythematosus, System

1977
Metabolism of immunoglobulin A, lymphocyte function, and histocompatibility antigens in patients on anticonvulsants.
    Journal of neurology, neurosurgery, and psychiatry, 1978, Volume: 41, Issue:4

    Topics: Adolescent; Adult; Aged; Blood Proteins; Epilepsy; Female; Folic Acid; HLA Antigens; Humans; Immunol

1978
Antipyretic analgesics in patients on antiepileptic drug therapy.
    European journal of clinical pharmacology, 1979, May-21, Volume: 15, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Carbamazepine; Drug Interactions; Epilepsy; Female;

1979
Measurement of the normal ventricular system and supratentorial subarachnoid space in children with computed tomography.
    Neuroradiology, 1979, May-15, Volume: 17, Issue:5

    Topics: Adolescent; Age Factors; Anesthesia, General; Cerebral Ventricles; Cerebral Ventriculography; Child;

1979
[Drug therapy of epilepsy].
    Der Internist, 1977, Volume: 18, Issue:2

    Topics: Age Factors; Anticonvulsants; Barbiturates; Benzodiazepines; Bromides; Carbamazepine; Chlormethiazol

1977
Drug interactions during anticonvulsant therapy in childhood: diphenylhydantoin, primidone, phenobarbitone, clonazepam, nitrazepam, carbamazepin and dipropylacetate.
    Neuropadiatrie, 1977, Volume: 8, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Interactions;

1977
Management of childhood epilepsy.
    British medical journal, 1977, Apr-16, Volume: 1, Issue:6067

    Topics: Child; Epilepsy; Humans; Phenobarbital; Phenytoin; Valproic Acid

1977
Implications of measuring anticonvulsant blood levels in epilepsy.
    Developmental medicine and child neurology, 1977, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Epilepsy; Humans; Middle Aged; Patient Compliance;

1977
Preliminary observations on valproic acid kinetics in patients with epilepsy.
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:5

    Topics: Adult; Child; Chromatography, Gas; Epilepsy; Humans; Phenobarbital; Phenytoin; Valerates; Valproic A

1977
High-pressure liquid chromatography and enzyme immunoassay compared with gas chromatography for determing phenytoin.
    Clinical chemistry, 1977, Volume: 23, Issue:9

    Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Costs and Cost Analysis; Epilepsy; Humans

1977
Deposits of plasma proteins in the skin during treatment with carbamazepine and diphenylhydantoin.
    Acta medica Scandinavica, 1977, Volume: 202, Issue:1-2

    Topics: Adult; Aged; Blood Proteins; Carbamazepine; Epilepsy; Female; Fluorescent Antibody Technique; Humans

1977
Epilepsy and IgA deficiency--the effect of sodium valproate.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977, Oct-08, Volume: 52, Issue:16

    Topics: Adult; Agammaglobulinemia; Carbamazepine; Epilepsy; Female; Humans; Immunoglobulin A; Male; Phenobar

1977
Choice of drug therapy in epilepsy.
    The Practitioner, 1977, Volume: 219, Issue:1312

    Topics: Acetazolamide; Anticonvulsants; Benzodiazepines; Carbamazepine; Clonazepam; Epilepsy; Ethosuximide;

1977
[Plasma levels of anticonvulsants. Experiences with routine plasma level determination of 6 different anticonvulsants].
    Fortschritte der Medizin, 1978, Jan-05, Volume: 96, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Ethos

1978
Serum protein binding of diphenylhydantoin in man. I. Interaction with sodium valproate.
    Il Farmaco; edizione pratica, 1978, Volume: 33, Issue:2

    Topics: Drug Interactions; Epilepsy; Humans; In Vitro Techniques; Phenytoin; Protein Binding; Valerates; Val

1978
Long-term use of the major anticonvulsant drugs.
    American family physician, 1978, Volume: 18, Issue:4

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximi

1978
Drugs for epilepsy.
    The Medical letter on drugs and therapeutics, 1979, Mar-23, Volume: 21, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital;

1979
Recent advances in drug therapy for epilepsy.
    Canadian Medical Association journal, 1979, Apr-07, Volume: 120, Issue:7

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Drug Interactions; Epilepsy; Humans; Phenobarbital; Phen

1979
The use of antiepileptic drugs.
    Annals of internal medicine, 1979, Volume: 90, Issue:2

    Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximide; Humans;

1979
Comparative trial of valproate sodium and clonazepam in chronic epilepsy.
    Archives of neurology, 1979, Volume: 36, Issue:5

    Topics: Adult; Ataxia; Benzodiazepinones; Chronic Disease; Clonazepam; Drug Therapy, Combination; Epilepsy;

1979
Serum protein binding of diphenylhydantoin in man. II. Interaction with sodium valproate in epileptic patients.
    Il Farmaco; edizione pratica, 1979, Volume: 34, Issue:1

    Topics: Adult; Binding, Competitive; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Phenyto

1979
Decreased plasma protein binding of phenytoin in patients on valproic acid.
    British journal of clinical pharmacology, 1979, Volume: 8, Issue:6

    Topics: Adolescent; Adult; Blood Proteins; Child; Creatinine; Depression, Chemical; Epilepsy; Humans; Phenyt

1979
[Changes in the thyroid hormone system with combined anticonvulsion treatment of epileptic children and adolescents (author's transl)].
    Klinische Padiatrie, 1977, Volume: 189, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Cholesterol; Drug Therapy, Combination; Enzyme In

1977
Haemopexin, caeruloplasmin and C3: effect of diphenylhydantion.
    Clinica chimica acta; international journal of clinical chemistry, 1977, Sep-15, Volume: 79, Issue:3

    Topics: Adolescent; Age Factors; Ceruloplasmin; Child; Child, Preschool; Complement C3; Complement System Pr

1977
[Anticonvulsants and simultaneous medication - a problem in pregnancy (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1977, Jun-24, Volume: 119, Issue:25

    Topics: Adult; Anticonvulsants; Antiemetics; Dihydroergotamine; Drug Combinations; Drug Interactions; Drug T

1977
Medical treatment of epilepsy: part I.
    Southern medical journal, 1978, Volume: 71, Issue:3

    Topics: Anticonvulsants; Bromides; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combina

1978
Medical treatment of epilepsy: Part II.
    Southern medical journal, 1978, Volume: 71, Issue:4

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Calcium; Child; Drug Interactions; Epilepsy; Ep

1978
Anticonvulsant therapy. Approaches to some common clinical problems.
    Postgraduate medicine, 1979, Volume: 65, Issue:3

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Eth

1979
Epilepsy among parents of children with facial clefts.
    Epilepsia, 1979, Volume: 20, Issue:1

    Topics: Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Male; Parents; Phenobarbital; Ph

1979
Epilepsy and pregnancy. Serum thyroxine levels during phenytoin therapy.
    Obstetrics and gynecology, 1979, Volume: 53, Issue:3

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Epilepsy; Female; Fetus; Humans; Infant, Newborn;

1979
Metabolism of diphenylhydantoin (phenytoin) during pregnancy.
    British journal of obstetrics and gynaecology, 1979, Volume: 86, Issue:2

    Topics: Adolescent; Adult; Epilepsy; Female; Humans; Phenytoin; Postpartum Period; Pregnancy; Pregnancy Comp

1979
Childhood cancer and drugs in pregnancy.
    British medical journal, 1979, Mar-17, Volume: 1, Issue:6165

    Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Fetus; Humans; Infant; Infant, Newborn

1979
Biochemical variables related to calcium metabolism in epileptics.
    Acta medica Scandinavica, 1979, Volume: 205, Issue:5

    Topics: Aged; Alkaline Phosphatase; Anticonvulsants; Calcium; Carbamazepine; Epilepsy; Female; Humans; Male;

1979
One drug for epilepsy [proceedings].
    British journal of clinical pharmacology, 1979, Volume: 7, Issue:4

    Topics: Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin

1979
Cerebellar stimulation: regional effects on a thalamocortical system.
    Epilepsia, 1979, Volume: 20, Issue:3

    Topics: Animals; Cats; Cerebellum; Electric Stimulation; Epilepsy; Evoked Potentials; Phenytoin; Thalamus

1979
Serum phenytoin, phenobarbital, carbamazepine, albumin; and plasma estradiol, progesterone concentrations during the menstrual cycle in women with epilepsy.
    Acta neurologica Scandinavica, 1979, Volume: 59, Issue:2-3

    Topics: Adult; Carbamazepine; Epilepsy; Estradiol; Female; Humans; Menstruation; Phenobarbital; Phenytoin; P

1979
Schizophrenia-like psychosis associated with anticonvulsant toxicity.
    The American journal of psychiatry, 1979, Volume: 136, Issue:7

    Topics: Adult; Anticonvulsants; Athetosis; Carbamazepine; Chorea; Dose-Response Relationship, Drug; Drug The

1979
[Dynamics of serum hydantoinate levels following single intravenous administration and simultaneous electroencephalographic changes].
    Ceskoslovenska neurologie a neurochirurgie, 1979, Volume: 42, Issue:3

    Topics: Adult; Brain; Child; Electroencephalography; Epilepsy; Female; Humans; Injections, Intravenous; Male

1979
Transient hyperkinesia after a single intravenous perfusion of diphenylhydantoin. Report of a case associated with nontoxic plasma levels of diphenylhydantoin.
    European neurology, 1979, Volume: 18, Issue:2

    Topics: Adolescent; Epilepsy; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Hyperkinesis; Infusions,

1979
[Drug therapy of epilepsy with control of the serum level of anti-epileptic agents].
    Fortschritte der Medizin, 1979, Jun-21, Volume: 97, Issue:23

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone;

1979
Drugs for epilepsy.
    British medical journal, 1979, Jun-09, Volume: 1, Issue:6177

    Topics: Carbamazepine; Epilepsy; Humans; Phenytoin

1979
Drugs for epilepsy.
    British medical journal, 1979, Jul-14, Volume: 2, Issue:6182

    Topics: Drug Therapy, Combination; Epilepsy; Humans; Male; Phenytoin

1979
Epilepsy and pregnancy.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1979, Volume: 6, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Coagulation Disorders; Chromosome Aberrations; C

1979
Chronic diphenyl hydantoin encephalopathy in mentally retarded children and adolescent with severe epilepsy.
    Acta neurologica Scandinavica, 1979, Volume: 60, Issue:1

    Topics: Adolescent; Adult; Brain Diseases; Child; Child, Preschool; Chronic Disease; Epilepsy; Female; Human

1979
Changes in serum triglyceride and cholesterol levels during long-term phenytoin treatment for epilepsy.
    Acta medica Scandinavica, 1979, Volume: 206, Issue:3

    Topics: Adolescent; Adult; Cholesterol; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Time Factors

1979
Phenytoin ("dilantin") and fits.
    The Journal of the Association of Physicians of India, 1979, Volume: 27, Issue:2

    Topics: Epilepsy; Humans; Phenytoin

1979
[Transient lowering of the IgA level during Diphedan therapy].
    Orvosi hetilap, 1979, Sep-09, Volume: 120, Issue:36

    Topics: Child; Child, Preschool; Epilepsy; Female; Humans; Immunoglobulin A; Male; Phenytoin

1979
Interaction between plasma phenytoin and phenobarbital concentrations in epileptic patients.
    Folia psychiatrica et neurologica japonica, 1979, Volume: 33, Issue:3

    Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Phenobarbital; Phenytoin

1979
Serum levels of phenytoin and phenobarbital in epileptic patients treated with mixture antiepileptic tablets, Comital-L or Hydantol-F.
    Folia psychiatrica et neurologica japonica, 1979, Volume: 33, Issue:3

    Topics: Anticonvulsants; Drug Combinations; Epilepsy; Humans; Mephobarbital; Phenobarbital; Phenytoin

1979
Effect of anticonvulsants on experimental cortical epilepsy induced by tungstic acid gel in rats.
    Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 241, Issue:2

    Topics: Animals; Anticonvulsants; Behavior, Animal; Electrocardiography; Electroencephalography; Epilepsy; F

1979
[Quantitative analysis of EEG basic rhythms in epileptics (author's transl)].
    No to shinkei = Brain and nerve, 1979, Volume: 31, Issue:11

    Topics: Adult; Alpha Rhythm; Delta Rhythm; Electroencephalography; Epilepsy; Female; Humans; Male; Middle Ag

1979
Problems in counseling the epileptic mother.
    Birth defects original article series, 1979, Volume: 15, Issue:5C

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Barbiturates; Epilepsy; Female; Genetic Counseling;

1979
Immunoglobulin G in serum and cerebrospinal fluid from epileptic patients treated with phenytoin.
    European neurology, 1979, Volume: 18, Issue:5

    Topics: Adolescent; Adult; Aged; Epilepsy; Female; Humans; Immunoglobulin A; Immunoglobulin G; Male; Middle

1979
Effectiveness of simplified dosage schedules on the management of ambulant epileptic patients.
    European neurology, 1979, Volume: 18, Issue:5

    Topics: Adolescent; Adult; Ambulatory Care; Drug Administration Schedule; Epilepsy; Female; Humans; Male; Mi

1979
[Fetal hydantoin syndrome (side effects of hydantoin preparations)].
    Orvosi hetilap, 1979, Oct-21, Volume: 120, Issue:42

    Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Fetal Diseases; Fetus; Humans; Infant, Newborn; Male;

1979
[Studies on the serum levels of the antiepileptic drugs-with particular reference to diphenylhydantoin, phenobarbital and carbamazepine-(author's transl)].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1979, Volume: 81, Issue:8

    Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsy; Humans; Middle Aged; Phenobarbi

1979
The [14C]-aminopyrine breath test. A comparison of different forms of analysis.
    British journal of clinical pharmacology, 1979, Volume: 8, Issue:6

    Topics: Aminopyrine; Breath Tests; Carbon Dioxide; Epilepsy; Glucaric Acid; Glutethimide; Humans; Liver Dise

1979
[Peripheral nerve function in patients with long-term anticonvulsant therapy (author's transl)].
    Rinsho shinkeigaku = Clinical neurology, 1979, Volume: 19, Issue:11

    Topics: Adolescent; Adult; Epilepsy; Female; Humans; Male; Middle Aged; Neural Conduction; Peripheral Nerves

1979
[Diphenylhydantoin stimulation test in Wilson's disease].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1979, Volume: 31, Issue:9

    Topics: Adult; Ceruloplasmin; Epilepsy; Female; Hepatolenticular Degeneration; Humans; Male; Middle Aged; Ph

1979
Antiopyrine half-life as a measure of hepatic enzyme induction: clinical applications in a chronic epileptic population.
    Clinical and experimental neurology, 1979, Volume: 16

    Topics: Adult; Antipyrine; Barbiturates; Enzyme Induction; Epilepsy; Female; Half-Life; Humans; Male; Micros

1979
The epoxide of carbamazepine.
    Clinical and experimental neurology, 1979, Volume: 16

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Biotransformation; Carbamazepine; Child; Child, Preschool;

1979
Problems with the use of conventional anticonvulsant drugs in mentally retarded individuals.
    Brain & development, 1979, Volume: 1, Issue:2

    Topics: Adolescent; Child; Child Behavior Disorders; Child, Preschool; Cognition; Epilepsy; Humans; Intellec

1979
Effects of subjects' sex, and intake of tobacco, alcohol and oral contraceptives on plasma phenytoin levels.
    British journal of clinical pharmacology, 1979, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Aged; Alcohol Drinking; Analysis of Variance; Child; Child, Preschool; Contracept

1979
Effect of increased bioavailability of phenytoin tablets on serum phenytoin concentration in epileptic out-patients.
    British journal of clinical pharmacology, 1979, Volume: 8, Issue:1

    Topics: Biological Availability; Dose-Response Relationship, Drug; Epilepsy; Humans; Phenytoin; Tablets

1979
The effect of salicylate on phenytoin pharmacokinetics.
    Transactions of the American Neurological Association, 1979, Volume: 104

    Topics: Aspirin; Drug Interactions; Epilepsy; Humans; Phenytoin

1979
Decreased phenytoin levels in antineoplastic therapy.
    Therapeutic drug monitoring, 1979, Volume: 1, Issue:2

    Topics: Adult; Antineoplastic Agents; Drug Interactions; Epilepsy; Humans; Intestinal Absorption; Male; Moni

1979
Effect of influenza vaccination on plasma phenytoin concentrations.
    Therapeutic drug monitoring, 1979, Volume: 1, Issue:2

    Topics: Epilepsy; Humans; Influenza Vaccines; Metabolic Clearance Rate; Phenytoin; Vaccination

1979
Predicting phenytoin dose - a revised nomogram.
    Therapeutic drug monitoring, 1979, Volume: 1, Issue:3

    Topics: Adolescent; Adult; Aged; Child; Epilepsy; Humans; Kinetics; Middle Aged; Phenytoin

1979
Plasma anticonvulsant concentrations during pregnancy.
    Neurology, 1977, Volume: 27, Issue:2

    Topics: Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications

1977
Induction of sex hormone binding globulin by phenytoin.
    British medical journal, 1977, Oct-08, Volume: 2, Issue:6092

    Topics: Adult; Epilepsy; Female; Humans; Phenytoin; Sex Hormone-Binding Globulin

1977
The fetal hydantoin syndrome. A case report.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1978, Jan-28, Volume: 53, Issue:4

    Topics: Abnormalities, Drug-Induced; Adult; Epilepsy; Female; Fetus; Humans; Hydantoins; Infant; Male; Pheny

1978
Controversies in the treatment of febrile convulsions.
    Neurology, 1979, Volume: 29, Issue:3

    Topics: Child; Epilepsy; Humans; Intelligence; Phenobarbital; Phenytoin; Prognosis; Seizures; Seizures, Febr

1979
The interrelationships between serum 25-hydroxycholecalciferol, serum parathyroid hormone and bone changes in anticonvulsant osteomalacia.
    Acta endocrinologica, 1977, Volume: 84, Issue:3

    Topics: Adolescent; Adult; Binding, Competitive; Calcium, Dietary; Epilepsy; Feeding Behavior; Female; Human

1977
Malignant mesenchymoma and birth defects. Prenatal exposure to phenytoin.
    JAMA, 1977, Jul-25, Volume: 238, Issue:4

    Topics: Adolescent; Adult; Cleft Lip; Cleft Palate; Epilepsy; Female; Follow-Up Studies; Humans; Male; Mater

1977
Removal of phenytoin by hemodialysis in uremic patients.
    JAMA, 1977, Oct-17, Volume: 238, Issue:16

    Topics: Adolescent; Adult; Epilepsy; Female; Half-Life; Humans; Male; Middle Aged; Phenytoin; Plasma; Renal

1977
[Methsuximide in the treatment of epilepsies (author's transl)].
    Der Nervenarzt, 1977, Volume: 48, Issue:7

    Topics: Adolescent; Adult; Child; Drug Evaluation; Drug Interactions; Epilepsy; Gastrointestinal Diseases; H

1977
Bioavailability of three phenytoin preparations in healthy subjects and in epileptics.
    European journal of clinical pharmacology, 1977, Dec-02, Volume: 12, Issue:4

    Topics: Adult; Biological Availability; Body Surface Area; Epilepsy; Female; Humans; Male; Phenytoin; Tablet

1977
A case of musicogenic epilepsy.
    Folia psychiatrica et neurologica japonica, 1977, Volume: 31, Issue:3

    Topics: Aged; Diazoxide; Electroencephalography; Epilepsy; Female; Humans; Music; Phenytoin

1977
Phenytoin, phenobarbitone and serum cholesterol.
    Scandinavian journal of social medicine, 1977, Volume: 5, Issue:3

    Topics: Adolescent; Adult; Cholesterol; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoi

1977
[Consequeces of the elimination of a combination drug. Transition from combination antisacer: attention].
    Schweizerische medizinische Wochenschrift, 1977, Dec-24, Volume: 107, Issue:51

    Topics: Adult; Drug Combinations; Epilepsy; Humans; Phenobarbital; Phenytoin

1977
[Epilepsy and contraception].
    Acta obstetrica y ginecologica hispano-lusitana, 1977, Volume: 25, Issue:6

    Topics: Contraceptives, Oral; Contraceptives, Oral, Hormonal; Drug Interactions; Epilepsy; Female; Humans; O

1977
Multiple drug interactions with phenytoin.
    The Medical journal of Australia, 1977, Oct-01, Volume: 2, Issue:14

    Topics: Alcoholism; Disulfiram; Epilepsy; Female; Humans; Middle Aged; Phenytoin; Substance Withdrawal Syndr

1977
A teratological evaluation of anticonvulsant drugs.
    Acta paediatrica Academiae Scientiarum Hungaricae, 1977, Volume: 18, Issue:2

    Topics: Abnormalities, Drug-Induced; Anencephaly; Anticonvulsants; Cleft Lip; Cleft Palate; Diazepam; Epilep

1977
The effects of toxic and non-toxic serum phenytoin levels on carbohydrate tolerance and insulin levels.
    Acta neurologica Scandinavica, 1977, Volume: 56, Issue:6

    Topics: Adolescent; Adult; Aged; Blood Glucose; Carbohydrate Metabolism; Child; Epilepsy; Female; Glucose To

1977
Serum protein binding of diphenylhydantoin in healthy man.
    Bollettino della Societa italiana di biologia sperimentale, 1977, Sep-15, Volume: 53, Issue:17

    Topics: Blood Proteins; Epilepsy; Female; Humans; Male; Phenytoin; Protein Binding; Temperature

1977
[Chromosomal in study patients treated with anticonvulsant drugs].
    Neurologia, neurocirugia, psiquiatria, 1977, Volume: 18, Issue:2-3 Suppl

    Topics: Adolescent; Adult; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human

1977
Stabilization of the thalamocortical motor system by cerebellar stimulation.
    Neurologia, neurocirugia, psiquiatria, 1977, Volume: 18, Issue:2-3 Suppl

    Topics: Animals; Cats; Cerebellar Cortex; Electric Stimulation; Electroencephalography; Epilepsy; Evoked Pot

1977
Phenytoin-related cerebellar degeneration without seizures.
    Annals of neurology, 1977, Volume: 2, Issue:5

    Topics: Cerebellum; Epilepsy; Female; Gliosis; Humans; Isoniazid; Middle Aged; Nerve Degeneration; Neuroglia

1977
Conjugate lateral gaze nystagmus and free phenytoin concentrations in plasma: lack of correlation.
    Epilepsia, 1978, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Aged; Electrooculography; Epilepsy; Female; Humans; Male; Middle Aged; Nystagmus,

1978
Acute and chronic antiepileptic drug effect on the T complex interhemispheric latency difference.
    Epilepsia, 1978, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Auditory Pathways; Brain; Child; Clonazepam; Electroenceph

1978
[Phenytoin side effects. A study of children and young people with severe epilepsy].
    Ugeskrift for laeger, 1978, Feb-13, Volume: 140, Issue:7

    Topics: Adolescent; Adult; Brain Diseases; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Phenytoi

1978
Simultaneous gas liquid chromatographic dosage of phenobarbital and diphenylhydantoin in serum.
    Il Farmaco; edizione pratica, 1978, Volume: 33, Issue:2

    Topics: Chromatography, Gas; Epilepsy; Humans; Phenobarbital; Phenytoin

1978
Electroencephalography and phenytoin toxicity in mentally retarded epileptic patients.
    Journal of neurology, neurosurgery, and psychiatry, 1978, Volume: 41, Issue:3

    Topics: Adolescent; Adult; Brain; Child; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy;

1978
One drug for epilepsy.
    British medical journal, 1978, May-06, Volume: 1, Issue:6121

    Topics: Drug Therapy, Combination; Epilepsy; Humans; Phenytoin

1978
[Do antiepileptics have a teratogenic effect?].
    Deutsche medizinische Wochenschrift (1946), 1978, Mar-24, Volume: 103, Issue:12

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Congenital Abnormalities; Epilepsy; Female; Humans; In

1978
The effects of dose, age, and sex on the serum levels of phenobarbital and diphenylhydantoin in epileptic patients.
    Pharmacological research communications, 1978, Volume: 10, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Epilepsy; Female; Humans; Kinetics; M

1978
[Optimizing the therapeutic process in long-term antiepileptic therapy through the determination of drug levels in patients].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1978, Volume: 30, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Drug Therapy; Epilepsy; Ethosuximide; Germany, East; Humans; Methods

1978
[Toxic "atrophie cerebelleuse". (problems associated with permanent cerebellar damage due to chronic diphenylhydantion intoxication)].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1978, Volume: 30, Issue:3

    Topics: Adult; Atrophy; Brain Damage, Chronic; Cerebellar Diseases; Epilepsy; Female; Humans; Phenytoin; Rad

1978
[Determination of serum levels of phenobarbital and diphenylhydantoin in the treatment of epilepsy].
    La Clinica terapeutica, 1978, Apr-15, Volume: 85, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Humans; Middle Aged; Phenobarbital; Phen

1978
Soft neurological correlates of compulsive eaters.
    The Journal of nervous and mental disease, 1978, Volume: 166, Issue:6

    Topics: Adolescent; Adult; Child; Compulsive Behavior; Eating; Electroencephalography; Epilepsy; Female; Hum

1978
Hematologic effects of phenytoin therapy during pregnancy.
    Obstetrics and gynecology, 1978, Volume: 51, Issue:6

    Topics: Carotenoids; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Hematologic Tests; Humans; Phenyto

1978
[Calcium and phospate metabolism disorders in patients on long-term diphenylhydantoin therapy].
    Polskie Archiwum Medycyny Wewnetrznej, 1978, Volume: 59, Issue:4

    Topics: Adolescent; Adult; Bone and Bones; Calcium; Epilepsy; Humans; Hypocalcemia; Magnesium; Middle Aged;

1978
Compliance with anticonvulsant therapy in a hospital clinic and in the community.
    British journal of clinical pharmacology, 1978, Volume: 6, Issue:1

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Drug Prescriptions; Epilepsy; Female; Humans; Male;

1978
[Phenytoin determination in blood in epileptic children].
    Kinderarztliche Praxis, 1978, Volume: 46, Issue:7

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Phenytoin; Protein Binding; Tim

1978
Individual variation in daily dosage requirements for phenytoin sodium in patients with epilepsy.
    British journal of clinical pharmacology, 1978, Volume: 6, Issue:3

    Topics: Adult; Age Factors; Body Weight; Drug Administration Schedule; Epilepsy; Female; Glucaric Acid; Huma

1978
Drug compliance and therapeutic considerations in 75 black epileptic children.
    The Central African journal of medicine, 1978, Volume: 24, Issue:7

    Topics: Adolescent; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Ma

1978
School-children with epilepsy at risk for learning and behaviour problems.
    Developmental medicine and child neurology, 1978, Volume: 20, Issue:4

    Topics: Achievement; Attention; Child; Child Behavior Disorders; Cognition; Dependency, Psychological; Epile

1978
Effect of anticonvulsant therapy on serum 25-hydroxyvitamin D level.
    The Tohoku journal of experimental medicine, 1978, Volume: 125, Issue:3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Humans; H

1978
[Antiepileptic emergency therapy in the adult age].
    Deutsche medizinische Wochenschrift (1946), 1978, Oct-20, Volume: 103, Issue:42

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Diazepam; Emergencies; Epilepsy; Humans; Phenobarbi

1978
Kinetics of drug interactions in the treatment of epilepsy.
    International journal of clinical pharmacology and biopharmacy, 1978, Volume: 16, Issue:10

    Topics: Animals; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Ethanol; Female; Humans; Kinet

1978
[Phenytoin intoxication and serum level].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1978, Volume: 30, Issue:7

    Topics: Adolescent; Adult; Aged; Ataxia; Athetosis; Attention; Child; Child, Preschool; Chorea; Dose-Respons

1978
Abdominal epilepsy. A cause of abdominal pain in adults.
    JAMA, 1978, Nov-24, Volume: 240, Issue:22

    Topics: Abdomen; Adolescent; Adult; Diagnosis, Differential; Electroencephalography; Epilepsy; Female; Human

1978
Fetal hydantoin syndrome in triplets. A unique experiment of nature.
    American journal of diseases of children (1960), 1978, Volume: 132, Issue:10

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Epilepsy; Face; Female; Growth Disorder

1978
Congenital malformations and seizure disorders in the offspring of parents with epilepsy.
    International journal of epidemiology, 1978, Volume: 7, Issue:3

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Barbiturates; Child; Child, Preschool; Congenital Ab

1978
[Blood levels of phenytoin and phenobarbital in epileptics treated with phenydantin and phenytoinum].
    Neurologia i neurochirurgia polska, 1978, Volume: 12, Issue:5

    Topics: Drug Synergism; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phenytoin

1978
[Change of diphenylhydantoin tolerance at the time of reaching puberty in a 16-year-old girl suffering from epilepsy].
    Neurologia i neurochirurgia polska, 1978, Volume: 12, Issue:5

    Topics: Adolescent; Drug Tolerance; Epilepsy; Female; Humans; Meniere Disease; Nystagmus, Pathologic; Phenyt

1978
Action of anticonvulsants on pentylenetetrazol-induced epileptiform activity on invertebrate neurones (Helix aspersa).
    Neuropharmacology, 1978, Volume: 17, Issue:11

    Topics: Action Potentials; Amobarbital; Animals; Anticonvulsants; Diazepam; Epilepsy; Helix, Snails; In Vitr

1978
[Severe cerebellar lesions caused by diphenylhydantoin--a contribution to the problem of hydantoin poisoning].
    Zeitschrift fur arztliche Fortbildung, 1978, Oct-01, Volume: 72, Issue:19

    Topics: Adolescent; Ataxia; Dietary Proteins; Dysarthria; Encephalitis; Epilepsy; Female; Humans; Nystagmus,

1978
Brain concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic patients.
    European journal of clinical pharmacology, 1978, Nov-09, Volume: 14, Issue:1

    Topics: Adolescent; Brain; Carbamazepine; Child; Epilepsy; Epoxy Compounds; Female; Humans; Male; Phenobarbi

1978
Comparison of serum phenytoin levels in epileptic patients who swallowed their phenytoin tablets with or without previous chewing.
    European journal of clinical pharmacology, 1978, Nov-27, Volume: 14, Issue:3

    Topics: Epilepsy; Humans; Phenytoin; Solubility; Tablets; Time Factors

1978
Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.
    Israel journal of medical sciences, 1978, Volume: 14, Issue:12

    Topics: Epilepsy; Humans; Male; Middle Aged; Multiple Myeloma; Phenytoin

1978
Preliminary report on the magnesium deficient rat as a model of epilepsy.
    Laboratory animal science, 1978, Volume: 28, Issue:6

    Topics: Age Factors; Animals; Disease Models, Animal; Epilepsy; Female; Magnesium Deficiency; Male; Phenobar

1978
[Measurement of the blood concentration of antiepileptic drugs. II Special cases].
    La Nouvelle presse medicale, 1975, May-24, Volume: 4, Issue:21

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Epilepsy; Ethosuximide; Humans; Phenobarbi

1975
Correlation between red cell and free plasma phenytoin levels in renal disease.
    Neurology, 1976, Volume: 26, Issue:9

    Topics: Adult; Aged; Epilepsy; Erythrocytes; Female; Humans; Kidney Diseases; Kidney Transplantation; Male;

1976
Proposals on antiepileptic pharmacotherapy for use in developing countries.
    Epilepsia, 1976, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Developing Countries; Diazepam

1976
Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy.
    Neurology, 1975, Volume: 25, Issue:1

    Topics: Acetazolamide; Adolescent; Age Factors; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy

1975
Findings in routine laboratory examination in progressive myoclonus epilepsy.
    Acta neurologica Scandinavica, 1975, Volume: 51, Issue:1

    Topics: Adolescent; Adult; Age Factors; Blood Glucose; Blood Proteins; Cerebrospinal Fluid Proteins; Child;

1975
Criteria for selection of patients for neurosurgical treatment.
    Advances in neurology, 1975, Volume: 8

    Topics: Adolescent; Age Factors; Child; Electroencephalography; Encephalitis; Epilepsies, Partial; Epilepsy;

1975
Thickening of the heel-pad associated with long-term Dilantin therapy.
    The American journal of roentgenology, radium therapy, and nuclear medicine, 1975, Volume: 124, Issue:1

    Topics: Anthropometry; Connective Tissue; Epilepsy; Female; Foot Diseases; Heel; Humans; Long-Term Care; Mal

1975
Systematic determination of the serum phenytoin level as an aid in the management of children with epilepsy.
    European neurology, 1975, Volume: 13, Issue:3

    Topics: Acetazolamide; Adolescent; Carbamazepine; Child; Child, Preschool; Contraceptives, Oral; Drug Intera

1975
Seizures in adolescents.
    The Medical clinics of North America, 1975, Volume: 59, Issue:6

    Topics: Adolescent; Anticonvulsants; Automobile Driving; Benzodiazepines; Carbamazepine; Diagnosis, Differen

1975
Diseases of the central nervous system: Epilepsy.
    British medical journal, 1975, Nov-01, Volume: 4, Issue:5991

    Topics: Age Factors; Diazepam; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Eth

1975
Sensible prescribing. XI.--Juvenile and adult epilepsy.
    The Practitioner, 1975, Volume: 215, Issue:1289

    Topics: Adolescent; Adult; Age Factors; Carbamazepine; Child; Clonazepam; Epilepsy; Epilepsy, Absence; Epile

1975
Effects of different dosages of anticonvulsant drugs on mental performance in patients with chronic epilepsy.
    Acta neurologica Scandinavica, 1975, Volume: 52, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Child; Chronic Disease; Dose-Response Relationship, Drug; Epilep

1975
The effect of oral physiotherapy on dilantin gingival hyperplasia.
    Journal of oral pathology, 1976, Volume: 5, Issue:1

    Topics: Adolescent; Epilepsy; Gingival Crevicular Fluid; Gingival Hyperplasia; Gingivectomy; Gingivitis; Hum

1976
Epilepsy: a controllable disease. Part 2. Drug therapy and nursing care.
    The American journal of nursing, 1976, Volume: 76, Issue:3

    Topics: Acute Disease; Adolescent; Anticonvulsants; Child; Epilepsy; Ethosuximide; Gingival Hyperplasia; Hum

1976
Phenytoin and phenobarbitone plasma clearance during pregnancy.
    Acta neurologica Scandinavica, 1976, Volume: 54, Issue:2

    Topics: Adult; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; Human

1976
Sodium valproate in the treatment of resistant epilepsy.
    Acta neurologica Scandinavica, 1976, Volume: 54, Issue:3

    Topics: Adolescent; Adult; Alopecia; Anticonvulsants; Body Weight; Diarrhea; Drug Interactions; Epilepsies,

1976
Epilepsy and other seizure disorders in children: drug management.
    The Journal of school health, 1976, Volume: 46, Issue:8

    Topics: Acetazolamide; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, T

1976
Behavioral management of epileptic seizures following EEG biofeedback training of the sensorimotor rhythm.
    Biofeedback and self-regulation, 1976, Volume: 1, Issue:1

    Topics: Action Potentials; Adolescent; Adult; Biofeedback, Psychology; Dose-Response Relationship, Drug; Ele

1976
Interactions of phenytoin and phenobarbital in terms of order and temporal spacing of administration in monkeys.
    Epilepsia, 1976, Volume: 17, Issue:4

    Topics: Animals; Drug Interactions; Epilepsy; Half-Life; Haplorhini; Macaca mulatta; Male; Phenobarbital; Ph

1976
Salivary phenytoin radioimmunoassay. A simple method of the assessment of non-protein bound drug concentrations.
    European journal of clinical pharmacology, 1977, Volume: 11, Issue:1

    Topics: Adult; Blood Proteins; Epilepsy; Half-Life; Humans; Phenytoin; Protein Binding; Radioimmunoassay; Sa

1977
Immunoglobulin levels and autoantibodies in epileptics on long-term anticonvulsant therapy.
    Acta medica Scandinavica, 1977, Volume: 201, Issue:1-2

    Topics: Adolescent; Adult; Anticonvulsants; Autoantibodies; Epilepsy; Female; Humans; Immunoglobulin A; Immu

1977
Athetosis and phenytoin toxicity.
    American journal of diseases of children (1960), 1977, Volume: 131, Issue:1

    Topics: Athetosis; Epilepsy; Humans; Infant; Male; Phenytoin

1977
Techniques for demonstration of the specificity of circulating anticoagulants against antihemophilic factor (factor VIII), with studies of two cases possibly related to diphenylhydantoin therapy.
    Blood, 1977, Volume: 49, Issue:3

    Topics: Adult; Anticoagulants; Blood Coagulation Tests; Epilepsy; Factor VIII; Humans; Immunoglobulins; Male

1977
Individualization of phenytoin dosage regimens.
    Clinical pharmacology and therapeutics, 1977, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Drug Administration Schedule; Epilepsy; Female; Humans; Kinetics; Male; Middle Ag

1977
Plasma concentrations of 5-(4-hydroxyphenyl)-5-phenylhydantoin in phenytoin-treated patients.
    Clinical pharmacology and therapeutics, 1977, Volume: 21, Issue:3

    Topics: Dose-Response Relationship, Drug; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylat

1977
Long-term of phenytoin: Effects on whole blood and red cell folate and haematological parameters.
    Scandinavian journal of haematology, 1977, Volume: 18, Issue:2

    Topics: Adolescent; Adult; Anemia, Megaloblastic; Child; Child, Preschool; Epilepsy; Erythrocyte Count; Eryt

1977
Menstrual epileptoid psychosis in an adolescent girl.
    American journal of diseases of children (1960), 1977, Volume: 131, Issue:3

    Topics: Adolescent; Catatonia; Epilepsy; Female; Humans; Menstruation; Neurocognitive Disorders; Phenytoin

1977
[Plasma concentrations after injection or infusion of phenytoin (author's transl)].
    Klinische Wochenschrift, 1977, Mar-01, Volume: 55, Issue:5

    Topics: Adult; Arrhythmias, Cardiac; Epilepsy; Female; Humans; Infusions, Parenteral; Injections, Intravenou

1977
Phenytoin-induced pseudolymphoma syndrome: an immunologic study.
    Archives of dermatology, 1977, Volume: 113, Issue:4

    Topics: Adult; Antibody Formation; Drug Hypersensitivity; Epilepsy; Female; Humans; Hypersensitivity, Delaye

1977
[Liver damage after long-term administration of phenylethylbarbituric acid and diphenylhydantoin].
    Ceskoslovenska neurologie a neurochirurgie, 1977, Volume: 40, Issue:2

    Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Humans; Leucy

1977
Plasma levels of phenobarbital and phenytoin in epileptic outpatients.
    European neurology, 1977, Volume: 15, Issue:3

    Topics: Adolescent; Adult; Ambulatory Care; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Human

1977
Serum levels of anticonvulsants and haematological sequelae in black epileptics.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977, Apr-09, Volume: 51, Issue:15

    Topics: Adolescent; Adult; Aged; Black People; Child; Child, Preschool; Drug Combinations; Epilepsy; Erythro

1977
[Symptomatic treatment of epilepsy].
    Gaceta medica de Mexico, 1977, Volume: 113, Issue:1

    Topics: Anticonvulsants; Diazepam; Epilepsy; Humans; Phenobarbital; Phenytoin

1977
[Serum phenytoin determination, its value in the treatment of epilepsy].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1977, Volume: 29, Issue:2

    Topics: Epilepsy; Humans; Phenytoin; Seizures

1977
[Poisoning by small doses of diphenylhydantoin].
    Revista espanola de cardiologia, 1977, Volume: 30, Issue:2

    Topics: Administration, Oral; Aged; Drug Combinations; Epilepsy; Humans; Male; Phenytoin; Poisoning

1977
Evidence of osteomalacia in an outpatient group of adult epileptics.
    Epilepsia, 1977, Volume: 18, Issue:1

    Topics: Adult; Aged; Diet; Epilepsy; Female; Humans; Male; Middle Aged; Osteomalacia; Phenobarbital; Phenyto

1977
Chromosome studies of bone marrow cells and peripheral blood lymphocytes from diphenylhydantoin-treated patients.
    Mutation research, 1977, Volume: 48, Issue:3-4

    Topics: Adult; Bone Marrow; Bone Marrow Cells; Cell Nucleus; Chromosomes; Epilepsy; Female; Humans; Lymphocy

1977
Plasma protein binding of phenytoin after cholecystectomy and neurosurgical operations.
    Acta neurologica Scandinavica, 1977, Volume: 55, Issue:6

    Topics: Adolescent; Adult; Blood Proteins; Cholecystectomy; Epilepsy; Female; Humans; Intracranial Aneurysm;

1977
Lack of effect of clonazepam on serum levels of diphenylhydantoin, phenobarbital and carbamazepine.
    Acta neurologica Scandinavica, 1977, Volume: 55, Issue:6

    Topics: Adolescent; Adult; Benzodiazepinones; Carbamazepine; Child; Clonazepam; Drug Interactions; Drug Ther

1977
The effect of anticonvulsant drugs which induce liver microsomal enzymes on derived and ingested phenobarbitone levels.
    Acta neurologica Scandinavica, 1977, Volume: 56, Issue:1

    Topics: Adolescent; Adult; Biotransformation; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Fem

1977
Acetazolamide-accelerated anticonvulsant osteomalacia.
    Archives of internal medicine, 1977, Volume: 137, Issue:8

    Topics: Acetazolamide; Adult; Anticonvulsants; Calcium; Epilepsy; Female; Humans; Mephobarbital; Osteomalaci

1977
The investigation of phenobarbitone, phenytoin and primidone in the death of epileptics.
    Medicine, science, and the law, 1977, Volume: 17, Issue:3

    Topics: Epilepsy; Forensic Medicine; Humans; Phenobarbital; Phenytoin; Primidone

1977
[Biotransformation and its modification by barbiturates].
    Zeitschrift fur Gastroenterologie, 1977, Volume: 15, Issue:6

    Topics: Binding Sites; Biotransformation; Drug Interactions; Enzyme Induction; Epilepsy; Humans; Liver; Live

1977
[The anti-epileptic drugs].
    Archives francaises de pediatrie, 1977, Volume: 34, Issue:3

    Topics: Age Factors; Anticonvulsants; Carbamazepine; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoi

1977
Cerebellar atrophy in phenytoin-treated mentally retarded epileptics.
    Epilepsia, 1977, Volume: 18, Issue:3

    Topics: Adolescent; Adult; Atrophy; Cerebellum; Child; Child, Preschool; Epilepsy; Female; Humans; Intellect

1977
Epilepsy.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977, Aug-20, Volume: 52, Issue:9

    Topics: Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phenytoin

1977
Evaluation of serum levels during prolonged combination therapy with phenytoin and phenobarbitone.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977, Aug-20, Volume: 52, Issue:9

    Topics: Adult; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Middle Aged; Phenobarbital; P

1977
Phenytoin dosage in the elderly.
    Age and ageing, 1977, Volume: 6, Issue:3

    Topics: Age Factors; Aged; Epilepsy; Female; Humans; Male; Phenytoin

1977
[Status epilepticus in Lennox-Gastaut syndrome; therapeutic aspects].
    Arquivos de neuro-psiquiatria, 1977, Volume: 35, Issue:3

    Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Child; Child, Preschool; Electroencephalography; Epi

1977
Interaction between phenytoin and imipramine.
    British journal of clinical pharmacology, 1977, Volume: 4, Issue:4

    Topics: Adult; Depression; Drug Interactions; Epilepsy; Humans; Imipramine; Phenytoin; Time Factors

1977
Distribution of plasma phenobarbital, diphenylhydantoin and primidone levels in epileptic patients.
    Folia psychiatrica et neurologica japonica, 1977, Volume: 31, Issue:2

    Topics: Adult; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Primidone

1977
[Diphenylhydantoin inducing a lupus erythematosus-like syndrome].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1977, Aug-15, Volume: 32, Issue:33

    Topics: Adult; Diagnosis, Differential; Epilepsy; Female; Humans; Lupus Erythematosus, Systemic; Male; Middl

1977
Pharmacokinetics of phenytoin following intravenous administration in epileptic patients.
    Il Farmaco; edizione pratica, 1977, Volume: 32, Issue:9

    Topics: Adult; Epilepsy; Humans; Injections, Intravenous; Kinetics; Male; Phenytoin

1977
Hydantoin ring glucuronidation: characterization of a new metabolite of 5,5-diphenylhydantoin in man and the rat.
    Biomedical mass spectrometry, 1977, Volume: 4, Issue:4

    Topics: Animals; Bile; Chemical Phenomena; Chemistry; Epilepsy; Glucuronates; Humans; Ions; Liver; Male; Mas

1977
Incidence of fracture in epileptics.
    Acta orthopaedica Scandinavica, 1977, Volume: 48, Issue:4

    Topics: Adult; Age Factors; Aged; Epilepsy; Female; Fractures, Bone; Humans; Male; Middle Aged; Osteomalacia

1977
Comparison of six procedures for the simultaneous determination of antiepileptic drugs.
    The American journal of medical technology, 1977, Volume: 43, Issue:10

    Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Epilepsy; Humans; Phenobarbital; Phenytoin; Pri

1977
[Determination of blood level of diphenylhydantoin in the treatment of epilepsy. The need for monitoring].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1977, Oct-15, Volume: 30, Issue:20

    Topics: Biological Availability; Epilepsy; Female; Humans; Male; Methods; Phenytoin

1977
Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants.
    Journal of neurology, neurosurgery, and psychiatry, 1976, Volume: 39, Issue:5

    Topics: Adult; Anticonvulsants; Dupuytren Contracture; Epilepsy; Female; Humans; Male; Middle Aged; Phenobar

1976
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
    The Journal of pediatrics, 1976, Volume: 89, Issue:2

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio

1976
Letter: Diazoxide-diphenylhydantoin interaction.
    The Journal of pediatrics, 1976, Volume: 89, Issue:2

    Topics: Child, Preschool; Diazoxide; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Hypogly

1976
Phenytoin-induced dystonia and choreoathetosis in two retarded epileptic children.
    Neurology, 1976, Volume: 26, Issue:5

    Topics: Athetosis; Child; Chorea; Epilepsy; Humans; Intellectual Disability; Male; Muscular Diseases; Phenyt

1976
Editorial: The control of anti-epileptic drug treatment.
    Developmental medicine and child neurology, 1976, Volume: 18, Issue:4

    Topics: Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin

1976
[Brain stem seizures with circumscrbed elementary symptoms].
    Der Nervenarzt, 1976, Volume: 47, Issue:9

    Topics: Adult; Amitriptyline; Ataxia; Brain Neoplasms; Brain Stem; Carbamazepine; Epilepsy; Female; Humans;

1976
[A laboratory method for the control of diphenylhydantoin treatment (author's transl)].
    Revista medica de Chile, 1976, Volume: 104, Issue:5

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Phenytoin

1976
Plasma levels of carbamazepine and carbamazepine-10,11-epoxide during treatment of epilepsy.
    European journal of clinical pharmacology, 1976, Mar-22, Volume: 09, Issue:5-6

    Topics: Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Epoxy Compounds; Humans; Phenytoin

1976
Immunoglobulin abnormalities in epileptic patients treated with diphenylhydantoin.
    Folia psychiatrica et neurologica japonica, 1976, Volume: 30, Issue:2

    Topics: Adolescent; Adult; Aged; Child; Dysgammaglobulinemia; Epilepsy; Female; Humans; Immunoglobulin A; Im

1976
Ascorbic acid concentrations in human plasma and cerebrospinal fluid [proceedings].
    The Proceedings of the Nutrition Society, 1976, Volume: 35, Issue:2

    Topics: Ascorbic Acid; Epilepsy; Humans; Phenobarbital; Phenytoin; Primidone

1976
Clonazepam: a review of its pharmacological properties and therapeutic efficacy in epilepsy.
    Drugs, 1976, Volume: 12, Issue:5

    Topics: Absorption; Animals; Antitussive Agents; Benzodiazepinones; Brain; Cats; Clonazepam; Drug Interactio

1976
Phenytoin-induced depression of salivary IgA and gingival hyperplasia.
    Epilepsia, 1976, Volume: 17, Issue:3

    Topics: Adolescent; Adult; Child; Depression, Chemical; Epilepsy; Gingival Hyperplasia; Humans; Immunoglobul

1976
Serum calcium balance during early phase of diphenylhydantoin therapy.
    International journal of clinical pharmacology and biopharmacy, 1976, Volume: 14, Issue:1

    Topics: Adolescent; Adult; Alkaline Phosphatase; Epilepsy; Female; Humans; Hydroxyproline; Hypocalcemia; Mal

1976
Use of phenytoin serum levels in a case of status epilepticus.
    Neurology, 1976, Volume: 26, Issue:9

    Topics: Adult; Burns; Epilepsy; Female; Humans; Oxacillin; Phenytoin

1976
Further observations on carbamazepine plasma levels in epileptic patients. Relationships with therapeutic and side effects.
    Neurology, 1976, Volume: 26, Issue:10

    Topics: Adult; Age Factors; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalography; Epileps

1976
[Influencing of the thyroid hormone system by long-term treatment with 5-5 diphenylhydantion in children and adolescens (author's transl)].
    Klinische Padiatrie, 1976, Volume: 188, Issue:5

    Topics: Adolescent; Child; Epilepsy; Female; Humans; Hypothalamus; Iodine; Liver; Male; Phenytoin; Protein B

1976
Death due to isoniazid (INH) and phenytoin.
    The British journal of psychiatry : the journal of mental science, 1976, Volume: 129

    Topics: Drug Interactions; Epilepsy; Female; Humans; Isoniazid; Middle Aged; Phenytoin; Tuberculosis, Lymph

1976
Reduced CSF IgG in patients treated with phenytoin (diphenylhydantoin).
    European neurology, 1976, Volume: 14, Issue:6

    Topics: Adolescent; Adult; Cerebrospinal Fluid Proteins; Child, Preschool; Epilepsy; Humans; Immunoglobulin

1976
A neuropathological case-study of myoclonus epilepsy.
    Folia psychiatrica et neurologica japonica, 1976, Volume: 30, Issue:3

    Topics: Adult; Brain Diseases; Cysts; Epilepsy; Humans; Male; Myoclonus; Phenytoin

1976
[Determination of plasma phenytoine and treatment of epileptics].
    Schweizerische medizinische Wochenschrift, 1976, Jul-03, Volume: 106, Issue:27

    Topics: Alcoholism; Epilepsy; Female; Humans; Male; Patient Compliance; Phenytoin

1976
Changes in serum immunoglobulin levels during phenytoin treatment of epilepsy.
    Acta neurologica Scandinavica, 1976, Volume: 54, Issue:5

    Topics: Adolescent; Adult; Child; Depression, Chemical; Epilepsy; Erythrocytes; Female; Folic Acid; Humans;

1976
Chromosomal damage in epileptics on monotherapy with carbamazepine and diphenylhydantoin.
    Human genetics, 1976, Dec-15, Volume: 34, Issue:3

    Topics: Adolescent; Adult; Carbamazepine; Chromosome Aberrations; Chromosomes; Epilepsy; Female; Humans; Mal

1976
[Current problems of phenytoin treatment (authors transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1976, Dec-28, Volume: 65, Issue:52

    Topics: Drug Interactions; Epilepsy; Humans; Phenytoin

1976
Anticonvulsant drugs and mental symptoms: a review.
    Psychological medicine, 1976, Volume: 6, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Folic Acid

1976
[Toxic epidermal necrolosys -- Lyell's syndrome in a patient protractedly treated by anti-epileptic agents].
    Ceskoslovenska dermatologie, 1976, Volume: 51, Issue:6

    Topics: Adult; Anticonvulsants; Barbiturates; Epilepsy; Humans; Male; Mephenytoin; Phenobarbital; Phenytoin;

1976
[Interval therapy of febrile convulsions for the management of their prognosis. I. Methods and therapeutic advice for interval therapy of febrile convulsions].
    Kinderarztliche Praxis, 1976, Volume: 44, Issue:11

    Topics: Child, Preschool; Epilepsy; Humans; Infant; Periodicity; Phenobarbital; Phenytoin; Recurrence; Seizu

1976
[Psychotropic drugs for behavior disorder treatment in oligophrenic epileptics].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1976, Volume: 28, Issue:10

    Topics: Adult; Epilepsy; Humans; Intellectual Disability; Methotrimeprazine; Phenytoin; Primidone; Promazine

1976
The necessity of drug level monitoring in anticonvulsant drug therapy.
    Canadian journal of physiology and pharmacology, 1976, Volume: 54, Issue:6

    Topics: Body Weight; Dose-Response Relationship, Drug; Epilepsy; Humans; Patient Compliance; Phenobarbital;

1976
[Pathological changes in the oral cavity and some problems of stomatological treatment of epileptics].
    Czasopismo stomatologiczne, 1975, Volume: 28, Issue:3

    Topics: Epilepsy; Gingival Hypertrophy; Humans; Phenytoin

1975
New uses for phenytoin.
    JAMA, 1975, Sep-29, Volume: 233, Issue:13

    Topics: Arrhythmias, Cardiac; Diabetic Neuropathies; Digitalis Glycosides; Drug Evaluation; Epilepsy; Gastro

1975
[Prospects of surgical treatment in hydantoin-induced gingival hyperplasia].
    Deutsche zahnarztliche Zeitschrift, 1976, Volume: 31, Issue:11

    Topics: Adolescent; Adult; Child; Epilepsy; Female; Gingival Hyperplasia; Gingivectomy; Humans; Hydantoins;

1976
[Histopathology of gingival manifestations of hydantoin therapy].
    Fogorvosi szemle, 1976, Volume: 69 Suppl

    Topics: Adolescent; Adult; Aged; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Gingiva; Gingiva

1976
[Prosthetic treatment of periodontal disease in epileptics].
    Fogorvosi szemle, 1976, Volume: 69 Suppl

    Topics: Epilepsy; Humans; Periodontal Diseases; Periodontal Prosthesis; Phenytoin

1976
The excessively small ventricle on computed axial tomography of the brain.
    Neuroradiology, 1976, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Brain; Brain Concussion; Brain Diseases; Brain Neoplasms; Cerebral Ventriculograp

1976
Letter: Sodium valproate in the treatment of intractable childhood epilepsy.
    Developmental medicine and child neurology, 1975, Volume: 17, Issue:4

    Topics: Diazepam; Drug Therapy, Combination; Epilepsy; Phenobarbital; Phenytoin; Primidone; Pyridoxine; Vale

1975
Elevation of diphenylhydantoin and primidone serum concentration by addition of dipropylacetate, a new anticonvulsant drug.
    Acta paediatrica Scandinavica, 1975, Volume: 64, Issue:5

    Topics: Child; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Primidone; Valerat

1975
Method for diphenylhydantoin and phenobarbital assay by gas chromatography.
    Pathologie-biologie, 1975, Volume: 23, Issue:5

    Topics: Buffers; Chloroform; Chromatography, Gas; Chromatography, Thin Layer; Colorimetry; Epilepsy; Humans;

1975
The adverse effect of anticonvulsant therapy on renal allograft survival. A preliminary report.
    The Journal of pediatrics, 1976, Volume: 88, Issue:1

    Topics: Adolescent; Anticonvulsants; Cadaver; Child; Child, Preschool; Epilepsy; Ethosuximide; Humans; Kidne

1976
The influence of aldosterone and anticonvulsant drugs on electroencephalographic and clinical disturbances induced by the spirolactone derivative, potassium canrenoate.
    Journal of the neurological sciences, 1975, Volume: 24, Issue:1

    Topics: Aldosterone; Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Dogs; Electroencepha

1975
Letter: Epanutin and isoniazid interaction.
    British medical journal, 1975, Jan-18, Volume: 1, Issue:5950

    Topics: Adult; Carbamazepine; Drug Interactions; Electroencephalography; Epilepsy; Ethambutol; Ethosuximide;

1975
Dermatology mediquiz. Case 5.
    Medical times, 1975, Volume: 103, Issue:3

    Topics: Adult; Diagnosis, Differential; Epilepsy; Female; Gingival Hypertrophy; Humans; Leukemia, Lymphoid;

1975
Harmful effect of megadoses of vitamins: electroencephalogram abnormalities and seizures induced by intravenous folate in drug-treated epileptics.
    The American journal of clinical nutrition, 1975, Volume: 28, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Electroencephalography; Epilepsy; Female; Folic Acid; Humans; Male;

1975
Anaesthesia and the epileptic pateint. A review.
    Anaesthesia, 1975, Volume: 30, Issue:1

    Topics: Adult; Anesthesia, General; Anticonvulsants; Barbiturates; Central Nervous System; Child, Preschool;

1975
The freezing lesion. III. The effects of diphenylhydantoin on potassium transport within nerve terminals from the primary foci.
    Brain research, 1975, Mar-14, Volume: 86, Issue:1

    Topics: Animals; Cats; Cerebral Cortex; Electroencephalography; Electrophysiology; Epilepsy; Freezing; In Vi

1975
Letter: Metric blood levels of diphenylhydantoin.
    Pediatrics, 1975, Volume: 55, Issue:2

    Topics: Epilepsy; Humans; Phenytoin

1975
Letter: Plasma levels of antidepressants and anticonvulsants.
    British medical journal, 1975, Mar-01, Volume: 1, Issue:5956

    Topics: Epilepsy; Humans; Phenytoin

1975
[Letter: Diphenylhydrantoin poisoning during disulfiram therapy].
    La Nouvelle presse medicale, 1975, Feb-15, Volume: 4, Issue:7

    Topics: Adult; Alcoholism; Biotransformation; Disulfiram; Enzyme Inhibitors; Epilepsy; Humans; Liver; Male;

1975
Iatrogenic osteomalacia in epileptic children. A controlled therapeutic trial.
    Acta paediatrica Scandinavica, 1975, Volume: 64, Issue:2

    Topics: Bone and Bones; Calcium; Epilepsy; Osteomalacia; Phenytoin; Placebos; Radius; Stimulation, Chemical;

1975
Letter; myocardial infarction in epileptics.
    British medical journal, 1975, Apr-12, Volume: 2, Issue:5962

    Topics: Epilepsy; Humans; Myocardial Infarction; Osteomalacia; Phenytoin; Vitamin D

1975
[Dynamics of the serum level increase of hydantoins following the begin of oral administration].
    Ceskoslovenska neurologie a neurochirurgie, 1975, Volume: 38, Issue:3

    Topics: Administration, Oral; Adult; Child; Epilepsy; Female; Humans; Male; Phenytoin; Time Factors

1975
Dilantin-induced disseminated intravascular coagulation with purpura fulminans. A case report.
    Annals of internal medicine, 1975, Volume: 83, Issue:2

    Topics: Adolescent; Blood Coagulation Tests; Disseminated Intravascular Coagulation; Epilepsy; Female; Hepar

1975
Serum magnesium levles in patients treated with phenytoin.
    Clinica chimica acta; international journal of clinical chemistry, 1975, Jul-23, Volume: 62, Issue:2

    Topics: Epilepsy; Humans; Magnesium; Phenytoin; Serum Albumin

1975
Chlormethiazole in status epilepticus--three cases.
    The Medical journal of Australia, 1975, Apr-26, Volume: 1, Issue:17

    Topics: Adult; Chlormethiazole; Diazepam; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin

1975
[Plasma concentration of phenytoin in epileptics--importance for the clinician].
    Schweizerische medizinische Wochenschrift, 1975, Jul-26, Volume: 105, Issue:30

    Topics: Adult; Child; Chromatography, Gas; Dose-Response Relationship, Drug; Epilepsy; Humans; Medication Er

1975
Delayed and insidious onset of diphenylhydantoin toxicity.
    Southern medical journal, 1975, Volume: 68, Issue:1

    Topics: Adolescent; Adult; Animals; Cerebellar Ataxia; Drug Interactions; Electroencephalography; Epilepsy;

1975
[Personality and sex behavior among epileptics during long term treatment with DPH].
    Bibliotheca psychiatrica, 1975, Issue:151

    Topics: Adolescent; Adult; Attitude; Epilepsy; Follicle Stimulating Hormone; Humans; Libido; Luteinizing Hor

1975
[Anti epileptic therapy with diphenylhydantoin with serum controls in childhood. Clinical experiences].
    Bibliotheca psychiatrica, 1975, Issue:151

    Topics: Adolescent; Body Weight; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Phenytoin

1975
[Determination of phenytoin in saliva and its clinical significance].
    Bibliotheca psychiatrica, 1975, Issue:151

    Topics: Adolescent; Adult; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Saliva

1975
[Effects of anticonvulsive treatment on drug elimination in man. Induction of liver hydroxylating enzyme system by diphenylhydantoin and carbamazepine].
    Bibliotheca psychiatrica, 1975, Issue:151

    Topics: Adult; Antipyrine; Bilirubin; Carbamazepine; Creatinine; Epilepsy; Female; Half-Life; Humans; Hydrox

1975
Diphenylhydantoin-induced gingival hyperplasia: its response to changes in drug dosage.
    Developmental medicine and child neurology, 1975, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Gingival Hyperplasia;

1975
[Diphenylhydantoin poisoning].
    Harefuah, 1975, Aug-01, Volume: 89, Issue:3

    Topics: Epilepsy; Humans; Phenytoin

1975
The management of epilepsy.
    The Medical journal of Australia, 1975, Jul-12, Volume: 2, Issue:2

    Topics: Amobarbital; Anticonvulsants; Diazepam; Drug Therapy, Combination; Emergencies; Epilepsy; Humans; Ph

1975
Maternal phenytoin ingestion and congenital abnormalities: report of a case.
    American journal of diseases of children (1960), 1975, Volume: 129, Issue:8

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anus, Imperforate; Bladder Exstrophy; E

1975
A rapid gas-liquid chromatographic determination of serum levels of phenobarbital and diphenyllhydantoin.
    Clinica chimica acta; international journal of clinical chemistry, 1975, Aug-04, Volume: 62, Issue:3

    Topics: Chromatography, Gas; Epilepsy; Humans; Microchemistry; Phenobarbital; Phenytoin

1975
The value of serum diphenylhydantoin (phenytoin) levels in the management of epilepsy.
    Proceedings of the Royal Society of Medicine, 1975, Volume: 68, Issue:2

    Topics: Child; Epilepsy; Humans; Mental Disorders; Phenytoin

1975
Teratogenic effects of diphenylhydantoin.
    Canadian Medical Association journal, 1975, Jan-11, Volume: 112, Issue:1

    Topics: Abnormalities, Drug-Induced; Adult; Breast; Epilepsy; Face; Female; Hernia, Inguinal; Hip Dislocatio

1975
Cognitive and motor-sensory performances in toxic and nontoxic epileptic subjects.
    Neurology, 1975, Volume: 25, Issue:2

    Topics: Adult; Attention; Cognition; Epilepsy; Female; Humans; Intelligence Tests; Male; Motor Skills; Pheno

1975
Congenital malformations due to anticonvulsive drugs.
    Obstetrics and gynecology, 1975, Volume: 45, Issue:4

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord

1975
Unexpected, unexplained death in epileptic patients.
    Neurology, 1975, Volume: 25, Issue:6

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Death, Sudden; Epilepsy; Female; Humans; Male; Mid

1975
Photically induced epilepsy in Papio papio as a model for drug studies.
    Advances in neurology, 1975, Volume: 10

    Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose-

1975
Delayed idiosyncratic psychosis with diphenylhydantoin.
    JAMA, 1975, Mar-10, Volume: 231, Issue:10

    Topics: Adult; Epilepsy; Female; Humans; Paranoid Disorders; Phenytoin; Psychoses, Substance-Induced; Time F

1975
Anticonvulsant drug blood levels.
    JAMA, 1975, Apr-07, Volume: 232, Issue:1

    Topics: Anticonvulsants; Ataxia; Diplopia; Drug Therapy, Combination; Epilepsy; Humans; Nystagmus, Pathologi

1975
Letter: Reporting of anticonvulsant blood levels.
    JAMA, 1975, Aug-25, Volume: 233, Issue:8

    Topics: Epilepsy; Humans; Phenytoin

1975
Status epilepticus.
    JAMA, 1975, Oct-27, Volume: 234, Issue:4

    Topics: Anesthesia, General; Anticonvulsants; Diazepam; Emergencies; Epilepsy; Humans; Injections, Intramusc

1975
The gingival hyperplasia resulting from diphenylhydantoin in children and adults.
    International journal of clinical pharmacology and biopharmacy, 1975, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Gingiv

1975
[Current viewpoints in drug treatment of epilepsy, with reference to the most common drugs in current use].
    Ugeskrift for laeger, 1975, Oct-06, Volume: 137, Issue:41

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin

1975
Relationships among dose, serum and CSF levels and urinary output in fenobarbital and fenitoin treatment of epileptics.
    Neurologie et psychiatrie, 1975, Volume: 13, Issue:2

    Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Middle Aged; Phe

1975
Comparative study of proteins and lactic dehydrogenase isoenzymes in the blood and cerebrospinal fluid of nontreated and of phenobarbital and diphenylhydantoin treated epileptic patients.
    Neurologie et psychiatrie, 1975, Volume: 13, Issue:3

    Topics: Blood Proteins; Cerebrospinal Fluid Proteins; Epilepsy; Humans; Isoenzymes; L-Lactate Dehydrogenase;

1975
Therapeutic response relationship to phenobarbital and diphenylhydantoin serum and cerebrospinal fluid levels in epileptics.
    Neurologie et psychiatrie, 1975, Volume: 13, Issue:3

    Topics: Adolescent; Adult; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Female; Huma

1975
Phenytoin and phenobarbital concentrations in saliva and plasma measured by radioimmunoassay.
    Clinical pharmacology and therapeutics, 1975, Volume: 18, Issue:6

    Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Humans; Infant; Middle Aged; Phenobarbital; Ph

1975
Diphenylhydantoin serum levels, toxicity, and neuropsychological performance in patients with epilepsy.
    Epilepsia, 1975, Volume: 16, Issue:4

    Topics: Adult; Blood-Brain Barrier; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Mental

1975
The effect of anticonvulsant therapy on serum levels of 25-hydroxy-vitamin D, calcium, and parathyroid hormone.
    The Journal of clinical endocrinology and metabolism, 1975, Volume: 41, Issue:06

    Topics: Calcium; Cholesterol; Epilepsy; Female; Humans; Hyperparathyroidism, Secondary; Hypocalcemia; Parath

1975
Folate and monoamine metabolism in epilepsy.
    Journal of the neurological sciences, 1975, Volume: 26, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Biogenic Amines; Epilepsy; Erythrocytes; Folic Acid; Homovanilli

1975
Fluctuations of plasma phenytoin levels on single dose and twice daily dose regimes.
    Proceedings of the Australian Association of Neurologists, 1975, Volume: 12

    Topics: Adolescent; Adult; Child; Chronic Disease; Drug Administration Schedule; Epilepsy; Female; Humans; M

1975
Hematologic toxicity of carbamazepine.
    Advances in neurology, 1975, Volume: 11

    Topics: Adult; Aged; Anemia, Aplastic; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Female; Hu

1975
Management of the difficult patient with complex partial seizures.
    Advances in neurology, 1975, Volume: 11

    Topics: Adult; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epileps

1975
Psychosocial management of patients with complex partial seizures.
    Advances in neurology, 1975, Volume: 11

    Topics: Adult; Alcoholism; Carbamazepine; Delivery of Health Care; Drug Administration Schedule; Epilepsy; E

1975
Epilepsy anticonvulsants and malformations.
    Birth defects original article series, 1975, Volume: 11, Issue:5

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec

1975
Interaction of diphenylhydantoin (DPH) and tolbutamide in man.
    European journal of clinical pharmacology, 1975, Volume: 8, Issue:1

    Topics: Adult; Animals; Blood Proteins; Drug Interactions; Epilepsy; Female; Humans; In Vitro Techniques; Ma

1975
Pharmacokinetics and side-effects of clonazepam and its 7-amino-metabolite in man.
    European journal of clinical pharmacology, 1975, Apr-04, Volume: 8, Issue:3-4

    Topics: Adolescent; Adult; Aged; Benzodiazepinones; Biotransformation; Child; Clonazepam; Drug Interactions;

1975
Effect of age, height, weight and sex on serum phenytoin concentration in epileptic patients.
    British journal of clinical pharmacology, 1975, Volume: 2, Issue:3

    Topics: Adult; Age Factors; Aged; Body Height; Body Weight; Epilepsy; Female; Humans; Male; Middle Aged; Phe

1975
Paroxysmal "nightmares". Sequel of a stroke responsive to diphenylhydantoin.
    Neurology, 1975, Volume: 25, Issue:11

    Topics: Aged; Dreams; Epilepsy; Humans; Male; Phenytoin; Sleep Wake Disorders

1975
Plasma level studies on different brands of sodium diphenylhydantoin (DPH) and primidone.
    International journal of clinical pharmacology and biopharmacy, 1975, Volume: 12, Issue:3

    Topics: Biological Availability; Capsules; Epilepsy; Female; Humans; Kinetics; Male; Phenobarbital; Phenytoi

1975
[Problems in the use of anti-epileptics. 2. Resorption and the influence of resorption].
    Die Pharmazie, 1975, Volume: 30, Issue:5

    Topics: Animals; Anticonvulsants; Child; Epilepsy; Humans; Hydroxylation; Milk; Phenobarbital; Phenytoin; Po

1975
Hydantoin derivatives and malignancies of the haemopoietic system.
    Acta medica Scandinavica, 1975, Volume: 198, Issue:4

    Topics: Adult; Epilepsy; Hematopoietic System; Humans; Lymphoma, Non-Hodgkin; Male; Middle Aged; Phenytoin

1975
Discrepancies in recommended dosage regimens of drugs.
    Journal of clinical pharmacology, 1976, Volume: 16, Issue:1

    Topics: Adult; Epilepsy; Humans; Phenobarbital; Phenytoin

1976
Acute athetosis as a result of phenytoin toxicity in a child.
    American journal of diseases of children (1960), 1976, Volume: 130, Issue:1

    Topics: Athetosis; Child, Preschool; Epilepsy; Humans; Male; Phenytoin

1976
Letter: Failure to confirm anticonvulsant hypomagnesaemia.
    British medical journal, 1976, Feb-07, Volume: 1, Issue:6005

    Topics: Epilepsy; Humans; Magnesium Deficiency; Phenobarbital; Phenytoin

1976
Interaction of quinidine with anticonvulsant drugs.
    The New England journal of medicine, 1976, Mar-25, Volume: 294, Issue:13

    Topics: Adult; Arrhythmias, Cardiac; Depression, Chemical; Drug Interactions; Enzyme Induction; Epilepsy; Fe

1976
Drugs for epilepsy.
    The Medical letter on drugs and therapeutics, 1976, Mar-12, Volume: 18, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital;

1976
[Drug induced IgA deficiency in epilepsy].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Feb-28, Volume: 96, Issue:6

    Topics: Adolescent; Adult; Child; Dysgammaglobulinemia; Epilepsy; Humans; Immunoglobulin A; Immunologic Defi

1976
Drug-induced IgA deficiency in epileptic patients.
    Archives of neurology, 1976, Volume: 33, Issue:4

    Topics: Adolescent; Adult; Age Factors; Depression, Chemical; Epilepsy; Female; Humans; IgA Deficiency; Immu

1976
Interlaboratory variability in determination of plasma antiepileptic drug concentrations.
    Archives of neurology, 1976, Volume: 33, Issue:5

    Topics: Anticonvulsants; Epilepsy; Ethosuximide; Humans; Laboratories; Phenobarbital; Phenytoin; Primidone;

1976
Letter: Treatment of ethanol intoxication.
    The New England journal of medicine, 1976, Jul-08, Volume: 295, Issue:2

    Topics: Alcoholism; Epilepsy; Humans; Phenytoin; Substance Withdrawal Syndrome

1976
[Determination of serum diphenylhydantoin during antiepileptic therapy].
    Der Nervenarzt, 1976, Volume: 47, Issue:4

    Topics: Adolescent; Adult; Aged; Body Weight; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Ma

1976
Liver biopsies in epileptics during anticonvulsant therapy.
    Acta medica Scandinavica, 1976, Volume: 199, Issue:5

    Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubi

1976
Anticonvulsant osteomalacia determined by quantitative analysis of bone changes. Population study and possible risk factors.
    Acta medica Scandinavica, 1976, Volume: 199, Issue:5

    Topics: Adolescent; Adult; Alkaline Phosphatase; Bone and Bones; Calcification, Physiologic; Calcium; Calciu

1976
Radioimmunoassay, enzyme immunoassay, spectrophotometry, and gas-liquid chromatography compared for determination of phenobarbital and diphenylhydantoin.
    Clinical chemistry, 1976, Volume: 22, Issue:6

    Topics: Chromatography, Gas; Cross Reactions; Enzymes; Epilepsy; Evaluation Studies as Topic; Humans; Immuno

1976
Treatment of epilepsy.
    The Practitioner, 1992, Volume: 236, Issue:1519

    Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Male; Phenytoin; Valproic Acid

1992
Cognitive functions, epileptic syndromes and antiepileptic drugs.
    Arquivos de neuro-psiquiatria, 1992, Volume: 50, Issue:1

    Topics: Adolescent; Adult; Carbamazepine; Child; Cognition; Epilepsy; Female; Humans; Male; Middle Aged; Phe

1992
U-54494A reduces 4-AP-induced afterdischarges of CA1 pyramidal cells in the hippocampal slice of the rat.
    Life sciences, 1992, Volume: 50, Issue:6

    Topics: 4-Aminopyridine; Animals; Anticonvulsants; Calcium; Electrophysiology; Epilepsy; Hippocampus; Male;

1992
A study of nerve conduction velocity in patients on diphenylhydantoin therapy.
    The Journal of the Association of Physicians of India, 1992, Volume: 40, Issue:9

    Topics: Action Potentials; Epilepsy; Humans; Motor Neurons; Neural Conduction; Neurons, Afferent; Peripheral

1992
Salivary concentrations of antiepileptic drugs, oestradiol and progesterone throughout pregnancy in epileptic women.
    Clinical and experimental neurology, 1992, Volume: 29

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Estradiol; Female; Humans; Osmolar Concentration; P

1992
What to do when the first anticonvulsant does not work.
    Seizure, 1992, Volume: 1, Issue:1

    Topics: Aminocaproates; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Lamotrigine; Phenytoin; Treatment

1992
Applications of molecular physics 'biotechnology' to the rational design of an improved phenytoin analogue.
    Seizure, 1992, Volume: 1, Issue:4

    Topics: Biotechnology; Computer Simulation; Drug Design; Epilepsy; Humans; Models, Molecular; Phenytoin; Phy

1992
Therapeutic drug monitoring improves seizure control and reduces anticonvulsant side-effects in patients with refractory epilepsy.
    Seizure, 1992, Volume: 1, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Monitoring; Electroencephalog

1992
Binding parameters of phenytoin during monotherapy and polytherapy.
    International journal of clinical pharmacology, therapy, and toxicology, 1992, Volume: 30, Issue:1

    Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Chromatography, Gas; Drug Interactions

1992
Phenytoin-induced IgG2 and IgG4 deficiencies in a patient with epilepsy.
    Acta paediatrica (Oslo, Norway : 1992), 1992, Volume: 81, Issue:8

    Topics: Child, Preschool; Epilepsy; Female; Humans; IgG Deficiency; Immunoglobulins; Immunoglobulins, Intrav

1992
Incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients in general medical practice.
    Community dentistry and oral epidemiology, 1992, Volume: 20, Issue:5

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Child; Dental Plaque Index; England; Epilepsy; Female

1992
Phenytoin metabolism during pregnancy.
    European journal of clinical pharmacology, 1992, Volume: 43, Issue:4

    Topics: Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications; Time Factors

1992
[The problem of diffuse cranial hyperostosis following cerebral trauma in early childhood--a case report].
    Aktuelle Radiologie, 1992, Volume: 2, Issue:6

    Topics: Brain Injuries; Epilepsy; Humans; Hyperostosis; Male; Middle Aged; Phenytoin

1992
Induction of sister chromatid exchanges in phenytoin treated & untreated patients with epilepsy.
    The Indian journal of medical research, 1992, Volume: 96

    Topics: Adolescent; Adult; Epilepsy; Female; Humans; Male; Mutagenicity Tests; Phenytoin; Sister Chromatid E

1992
Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases.
    Journal of neurology, neurosurgery, and psychiatry, 1992, Volume: 55, Issue:11

    Topics: Adolescent; Adult; Angiography; Brain Neoplasms; Carbamazepine; Cerebral Hemorrhage; Child; Epilepsy

1992
"An analysis of epileptic patients nonresponsive to drugs".
    The Journal of the Association of Physicians of India, 1992, Volume: 40, Issue:7

    Topics: Anticonvulsants; Carbamazepine; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combina

1992
Cognitive effects of antiepileptic drug discontinuation.
    Epilepsia, 1992, Volume: 33 Suppl 6

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Epilepsy; Humans;

1992
Bioavailability studies of drugs with nonlinear pharmacokinetics: I. Tracer dose AUC varies directly with serum concentration.
    Journal of clinical pharmacology, 1992, Volume: 32, Issue:12

    Topics: Adolescent; Adult; Aged; Biological Availability; Epilepsy; Humans; Male; Middle Aged; Phenytoin

1992
Long-term influence of anticonvulsant agents on calcitonin, parathyroid hormone and osteocalcin.
    European neurology, 1992, Volume: 32, Issue:6

    Topics: Adult; Anticonvulsants; Calcitonin; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epi

1992
Enhanced prostaglandin biosynthesis in human gingival fibroblasts isolated from patients treated with phenytoin.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1992, Volume: 21, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acids; Cells, Cultured; Child; Dinoprostone; Dose-Response

1992
Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy.
    Therapeutic drug monitoring, 1992, Volume: 14, Issue:4

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbama

1992
[Occurrence of the protozoa, Entamoeba gingivalis and Trichomonas tenax in the mouths of children and adolescents with hyperplastic gingivitis caused by phenytoin].
    Bratislavske lekarske listy, 1992, Volume: 93, Issue:3

    Topics: Adolescent; Animals; Child; Entamoeba; Epilepsy; Female; Gingivitis; Humans; Male; Mouth; Phenytoin;

1992
Elevation of plasma phenytoin by viloxazine in epileptic patients: a clinically significant drug interaction.
    Journal of neurology, neurosurgery, and psychiatry, 1992, Volume: 55, Issue:2

    Topics: Adult; Aged; Depressive Disorder; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Ph

1992
Postmortem concentrations of phenytoin in different regions of the brain and in the serum: analysis of autoptic specimens from 24 epileptic patients.
    Therapeutic drug monitoring, 1992, Volume: 14, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Brain; Chromatography, High Pressure Liquid; Epilepsy; Female; Human

1992
Phenytoin and carbamazepine decreased oral bioavailability of praziquantel.
    Neurology, 1992, Volume: 42, Issue:3 Pt 1

    Topics: Adult; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Male; Phenytoin; Praziquant

1992
Comparison on bioequivalence of four phenytoin preparations in patients with multiple-dose treatment.
    Journal of clinical pharmacology, 1992, Volume: 32, Issue:3

    Topics: Administration, Oral; Biological Availability; Chemistry, Pharmaceutical; Chromatography, High Press

1992
Phenytoin and smoking.
    New York state journal of medicine, 1992, Volume: 92, Issue:2

    Topics: Adult; Aged; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Smoking; Tranquilizing Agents

1992
Pharmacogenetics and drug interactions: role in antiepileptic-drug-induced teratogenesis.
    Neurology, 1992, Volume: 42, Issue:4 Suppl 5

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Disease Susceptibility; Epilepsy; Epoxide Hydrolases;

1992
Epilepsy, antiepileptic drugs, and malformations in children of women with epilepsy: a French prospective cohort study.
    Neurology, 1992, Volume: 42, Issue:4 Suppl 5

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cohort Studies; Epilepsy; Female; Humans; Odds

1992
Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.
    Neurology, 1992, Volume: 42, Issue:4 Suppl 5

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Prescriptions; Epi

1992
Clinical utility of unbound antiepileptic drug blood levels in the management of epilepsy.
    Neurology, 1992, Volume: 42, Issue:5

    Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Valproic Aci

1992
Course of pregnancy and fetal outcome following maternal exposure to carbamazepine and phenytoin: a prospective study.
    Reproductive toxicology (Elmsford, N.Y.), 1992, Volume: 6, Issue:3

    Topics: Abnormalities, Drug-Induced; Analysis of Variance; Carbamazepine; Epilepsy; Female; Humans; Phenytoi

1992
Toxic reaction following the combined administration of fluoxetine and phenytoin: two case reports.
    Journal of neurology, neurosurgery, and psychiatry, 1992, Volume: 55, Issue:5

    Topics: Aged; Aged, 80 and over; Depressive Disorder; Drug Therapy, Combination; Epilepsy; Female; Fluoxetin

1992
[Long-term phenytoin (Diphedan) therapy leading to IgA nephropathy].
    Orvosi hetilap, 1992, Jun-28, Volume: 133, Issue:26

    Topics: Adult; Epilepsy; Glomerulonephritis, IGA; Humans; Male; Nephritis, Interstitial; Phenytoin

1992
Anticonvulsant-induced chronic pancreatitis. A case report.
    The Italian journal of gastroenterology, 1992, Volume: 24, Issue:5

    Topics: Adult; Anticonvulsants; Carbamazepine; Chronic Disease; Cytochrome P-450 Enzyme System; Epilepsy; Fr

1992
More on high-dose busulfan and seizure prophylaxis.
    Bone marrow transplantation, 1992, Volume: 9, Issue:2

    Topics: Adult; Bone Marrow Purging; Bone Marrow Transplantation; Busulfan; Epilepsy; Female; Humans; Leukemi

1992
Kindling as a model of drug-resistant partial epilepsy: selection of phenytoin-resistant and nonresistant rats.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:2

    Topics: Animals; Carbamazepine; Drug Resistance; Electrodes; Epilepsy; Female; Kindling, Neurologic; Phenyto

1991
Ralitoline (CI-946) and CI-953 block sustained repetitive sodium action potentials in cultured mouse spinal cord neurons and displace batrachotoxinin A 20-alpha-benzoate binding in vitro.
    Epilepsy research, 1991, Volume: 8, Issue:3

    Topics: Action Potentials; Animals; Anticonvulsants; Batrachotoxins; Carbamazepine; Cells, Cultured; Electro

1991
Phosphorylation of brain (Na+,K+)-ATPase alpha catalytic subunits in normal and epileptic cerebral cortex: I. The audiogenic mice and the cat with a freeze lesion.
    Journal of neuroscience research, 1991, Volume: 29, Issue:2

    Topics: Acoustic Stimulation; Animals; Brain; Catalysis; Cats; Cerebral Cortex; Electrophoresis, Polyacrylam

1991
Phosphorylation of brain (Na+,K+)-ATPase alpha catalytic subunits in normal and epileptic cerebral cortex: II. Partial seizures in human epilepsy.
    Journal of neuroscience research, 1991, Volume: 29, Issue:2

    Topics: Brain; Catalysis; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Epilepsies, Partial; Epileps

1991
Crusted scabies in acquired selective IgA deficiency.
    Acta dermato-venereologica, 1991, Volume: 71, Issue:3

    Topics: Adult; Dysgammaglobulinemia; Epilepsy; Humans; IgA Deficiency; Male; Phenytoin; Scabies

1991
Influence of antiepileptic drugs on sleep patterns.
    Epilepsy research. Supplement, 1991, Volume: 2

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain; Carbamazepine; Chil

1991
Outpatient compliance with theophylline and phenytoin therapy.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1991, Dec-07, Volume: 80, Issue:11-12

    Topics: Adolescent; Adult; Asthma; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Infant, Newbor

1991
Estimating phenytoin dosages in black African and Indian children.
    Clinical pharmacy, 1991, Volume: 10, Issue:12

    Topics: Adolescent; Bayes Theorem; Black People; Child; Child, Preschool; Epilepsy; Feedback; Humans; India;

1991
A Bayesian graphic method for predicting individual phenytoin dosage schedule.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1991, Volume: 12, Issue:2

    Topics: Adolescent; Adult; Bayes Theorem; Drug Administration Schedule; Epilepsy; Female; Humans; Male; Midd

1991
[Evaluation of the effectiveness of monotherapy in the treatment of epilepsy].
    Minerva medica, 1991, Volume: 82, Issue:12

    Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Drug Evaluation; Epilepsy; Humans; Middle Aged; Pheno

1991
[Epilepsy in Spain: comments concerning an unusual factor in decompensation].
    Medicina clinica, 1991, Nov-02, Volume: 97, Issue:15

    Topics: Anticonvulsants; Epilepsy; Humans; Phenytoin; Spain

1991
Phenytoin toxicity in a patient with isoniazid-induced hepatitis.
    Tubercle, 1991, Volume: 72, Issue:4

    Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Interactions; Epilepsy; Female; Humans; Isoniazi

1991
[Binding of phenytoin to serum albumin in vitro and in vivo].
    Ceskoslovenska farmacie, 1991, Volume: 40, Issue:6-7

    Topics: Adult; Epilepsy; Female; Humans; In Vitro Techniques; Male; Phenytoin; Protein Binding; Serum Albumi

1991
Mycosis fungoides-like lesions associated with phenytoin and carbamazepine therapy.
    Journal of the American Academy of Dermatology, 1991, Volume: 24, Issue:2 Pt 1

    Topics: Adult; Aged; Aged, 80 and over; Carbamazepine; Diagnosis, Differential; Drug Eruptions; Epilepsy; Fe

1991
[Altered monoamine metabolism in children with epilepsy].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1991, Volume: 24, Issue:1

    Topics: Biogenic Monoamines; Child; Epilepsy; Female; Humans; Male; Phenytoin

1991
Comparison of gabapentin with other antiepileptic and GABAergic drugs.
    Epilepsy research, 1991, Volume: 8, Issue:3

    Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Carbamazepine; Cats; Cyclohexanecarbo

1991
Plasma uric acid in patients receiving anticonvulsant monotherapy.
    Epilepsy research, 1991, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenobarbital; Phenytoin; Prosp

1991
Regression of phenytoin-induced gingival overgrowth after withdrawal of medication.
    Swedish dental journal, 1991, Volume: 15, Issue:3

    Topics: Adolescent; Child; Epilepsy; Female; Gingival Hyperplasia; Gingival Pocket; Humans; Male; Periodonta

1991
Sleep spindles in epilepsy.
    Clinical EEG (electroencephalography), 1991, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Aged; Carbamazepine; Drug Therapy, Combination; Electroencephalography; Epilepsy;

1991
A specific 70K protein found in epileptic rat cortex: induction of bursting activity and negative resistance by its intracellular application in Euhadra neurons.
    Journal of neurobiology, 1991, Volume: 22, Issue:3

    Topics: Animals; Antibodies, Anti-Idiotypic; Antibody Specificity; Calcium; Cerebral Cortex; Electrophoresis

1991
A reduction in verapamil concentrations with phenytoin.
    The New England journal of medicine, 1991, Oct-17, Volume: 325, Issue:16

    Topics: Adult; Cardiomyopathy, Hypertrophic; Drug Interactions; Epilepsy; Female; Humans; Phenytoin; Verapam

1991
[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].
    Rinsho shinkeigaku = Clinical neurology, 1991, Volume: 31, Issue:3

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Carbamazepine; Embryonic and Feta

1991
Epileptic patients refractory to drug therapy.
    Italian journal of neurological sciences, 1991, Volume: 12, Issue:5

    Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Immunoglobulin G; Immunoglobulins; Male; Middle Aged

1991
Clinical response in epilepsy in relation to total and free serum levels of phenytoin.
    Therapeutic drug monitoring, 1991, Volume: 13, Issue:5

    Topics: Adolescent; Adult; Aged; Biological Availability; Blood Proteins; Child; Child, Preschool; Drug Moni

1991
Measurement of phenytoin and carbamazepine in an ultrafiltrate of saliva.
    Therapeutic drug monitoring, 1991, Volume: 13, Issue:5

    Topics: Adolescent; Adult; Aged; Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Drug

1991
Methsuximide for intractable childhood seizures.
    Pediatrics, 1991, Volume: 87, Issue:2

    Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dr

1991
A novel protein induced in cortical epileptic focus of rat cerebrum: a possible linkage to epileptogenesis.
    Experimental neurology, 1991, Volume: 111, Issue:2

    Topics: Animals; Cerebral Cortex; Cobalt; Epilepsy; Immune Sera; Immunohistochemistry; Male; Microscopy, Ele

1991
Seizures: introduction and commentary.
    Pediatric annals, 1991, Volume: 20, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Humans; Phenobarbital; Phenytoin; Valpr

1991
Seizure-associated speech arrest in elderly patients.
    Mayo Clinic proceedings, 1991, Volume: 66, Issue:3

    Topics: Aged; Aged, 80 and over; Aphasia; Electroencephalography; Epilepsy; Female; Humans; Male; Phenytoin

1991
Evaluation and treatment of seizures.
    The New England journal of medicine, 1991, Apr-25, Volume: 324, Issue:17

    Topics: Child; Epilepsy; Humans; Phenytoin; Seizures

1991
Nomogram for the prediction of unbound phenytoin concentrations in patients on a combined treatment of phenytoin and valproic acid.
    European neurology, 1991, Volume: 31, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Chromatography, Gas; Chromatogr

1991
Fetal phenytoin exposure, hypoplastic nails, and jitteriness.
    Archives of disease in childhood, 1991, Volume: 66, Issue:3

    Topics: Abnormalities, Drug-Induced; Akathisia, Drug-Induced; Epilepsy; Female; Fetus; Humans; Infant, Newbo

1991
Comparison of methods for the prediction of phenytoin concentrations.
    Journal of clinical pharmacy and therapeutics, 1991, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Bayes Theorem; Dose-Response Relationship, Drug; Epil

1991
Epilepsy after craniotomy and the place of prophylactic anticonvulsant drugs: discussion paper.
    Journal of the Royal Society of Medicine, 1991, Volume: 84, Issue:4

    Topics: Carbamazepine; Craniotomy; Epilepsy; Humans; Phenytoin; Postoperative Complications; Retrospective S

1991
Hydantoin immunosuppression clinical study.
    Journal of the Egyptian Society of Parasitology, 1991, Volume: 21, Issue:1

    Topics: Adolescent; Adult; Antibody Formation; Epilepsy; Female; Humans; Immunoglobulins; Male; Middle Aged;

1991
[Bradyarrhythmias induced by antiepileptics increase frequency of epileptic seizures].
    Lakartidningen, 1991, May-08, Volume: 88, Issue:19

    Topics: Aged; Bradycardia; Carbamazepine; Epilepsy; Humans; Male; Phenytoin

1991
Effects of acute valproic acid administration on carnitine plasma concentrations in epileptic patients.
    Epilepsy research, 1991, Volume: 8, Issue:2

    Topics: Adult; Ammonia; Carnitine; Epilepsy; Humans; Phenobarbital; Phenytoin; Valproic Acid

1991
Protein changes associated with cobalt-induced epileptic activity in rat cerebral cortex.
    Epilepsy research, 1991, Volume: 8, Issue:2

    Topics: Animals; Behavior, Animal; Cerebral Cortex; Cobalt; Electroencephalography; Epilepsy; Male; Motor Co

1991
Anti-IgA antibodies in epileptic patients with a low serum IgA concentration.
    International journal of immunopharmacology, 1991, Volume: 13, Issue:2-3

    Topics: Antibodies, Anti-Idiotypic; Dysgammaglobulinemia; Epilepsy; Humans; IgA Deficiency; Immunoglobulin A

1991
[Pellagra in anticonvulsive therapy].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1990, Volume: 138, Issue:12

    Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Humans; Intellect

1990
The effects of phenytoin and carbamazepine on serum concentrations of mono-unsaturated metabolites of valproic acid.
    British journal of clinical pharmacology, 1990, Volume: 29, Issue:1

    Topics: Adult; Aged; Biotransformation; Carbamazepine; Drug Interactions; Epilepsy; Female; Humans; Male; Mi

1990
Fluctuations of unbound and total phenytoin concentrations during the day in epileptic patients on valproic acid comedication.
    Therapeutic drug monitoring, 1990, Volume: 12, Issue:2

    Topics: Adolescent; Adult; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Middle Aged; Phen

1990
Anticonvulsant therapy increases fentanyl requirements during anaesthesia for craniotomy.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1990, Volume: 37, Issue:3

    Topics: Adolescent; Adult; Anesthesia, Intravenous; Anticonvulsants; Carbamazepine; Craniotomy; Drug Interac

1990
Eyelid twitching seizures and generalized tonic-clonic convulsions: a syndrome of idiopathic generalized epilepsy.
    Annals of neurology, 1990, Volume: 27, Issue:3

    Topics: Acetazolamide; Adult; Epilepsy; Eyelid Diseases; Female; Humans; Phenytoin; Spasm; Valproic Acid

1990
Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy.
    Therapeutic drug monitoring, 1990, Volume: 12, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Carbamazepine; Chromatography, High Pressure Liquid; Drug I

1990
Possible roles for frequent salivary antiepileptic drug monitoring in the management of epilepsy.
    Epilepsy research, 1990, Volume: 6, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Female; Humans; Male; Menstrua

1990
[High-dose monotherapy in intractable epilepsy].
    Zhonghua nei ke za zhi, 1990, Volume: 29, Issue:4

    Topics: Adolescent; Adult; Carbamazepine; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; Female; Huma

1990
Treatment of epilepsy in people with multiple handicap.
    Archives of disease in childhood, 1990, Volume: 65, Issue:4

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Disabled Persons; Epilepsy; Hum

1990
Panel discussion: the oral manifestations of gingival hyperplasia.
    Compendium (Newtown, Pa.). Supplement, 1990, Mar-06, Issue:14

    Topics: Dental Care for Disabled; Epilepsy; Gingival Hyperplasia; Humans; Oral Hygiene; Phenytoin

1990
Effect of posture on total phenytoin plasma concentration.
    European journal of clinical pharmacology, 1990, Volume: 38, Issue:5

    Topics: Adult; Aged; Epilepsy; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Phenytoin; Postur

1990
Direct serum injection high-performance liquid chromatographic method for the simultaneous determination of phenobarbital, carbamazepine and phenytoin.
    Journal of chromatography, 1990, May-18, Volume: 527, Issue:2

    Topics: Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Humans; Immunoenzyme Techniques; Phen

1990
Neocerebellar hypoplasia in a neonate following intra-uterine exposure to anticonvulsants.
    Developmental medicine and child neurology, 1990, Volume: 32, Issue:8

    Topics: Abnormalities, Drug-Induced; Cerebellum; Drug Therapy, Combination; Epilepsy; Female; Humans; Nerve

1990
A specific 70 kDa protein induced in the epileptogenic cortex of rats elicits bursting activity and inactivation of potassium current in snail neurons.
    Neuroscience letters, 1990, Jul-17, Volume: 115, Issue:1

    Topics: Animals; Cerebral Cortex; Epilepsy; In Vitro Techniques; Membrane Potentials; Molecular Weight; Nerv

1990
[A case of childhood choreoathetosis induced by diphenylhydantoin].
    Anales espanoles de pediatria, 1990, Volume: 32, Issue:6

    Topics: Athetosis; Chorea; Dose-Response Relationship, Drug; Epilepsy; Humans; Infant; Male; Phenytoin

1990
Rapid anti-epileptic drug assay.
    Developmental medicine and child neurology, 1990, Volume: 32, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Hum

1990
Foetal hydantoin syndrome.
    Journal of the Indian Medical Association, 1990, Volume: 88, Issue:6

    Topics: Abnormalities, Multiple; Clubfoot; Epilepsy; Facial Bones; Female; Humans; Infant, Newborn; Phenytoi

1990
Cardiac arrhythmia and epilepsy.
    Journal of the Royal Society of Medicine, 1990, Volume: 83, Issue:8

    Topics: Adolescent; Epilepsy; Humans; Male; Phenytoin; Tachycardia, Supraventricular

1990
Acne keloidalis-like lesions on the scalp associated with antiepileptic drugs.
    International journal of dermatology, 1990, Volume: 29, Issue:8

    Topics: Acne Keloid; Adult; Carbamazepine; Epilepsy; Humans; Male; Phenytoin; Scalp Dermatoses

1990
Effects of age and antiepileptic drugs on plasma levels and kinetics of clobazam and N-desmethylclobazam.
    Pharmacology & toxicology, 1990, Volume: 67, Issue:2

    Topics: Adolescent; Adult; Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepin

1990
Deteriorating epilepsies: severely deteriorated cases.
    The Japanese journal of psychiatry and neurology, 1990, Volume: 44, Issue:2

    Topics: Adult; Anticonvulsants; Ataxia; Brain Damage, Chronic; Diagnosis, Differential; Drug Therapy, Combin

1990
Five epileptic cases who manifested psychotic states under the toxic levels of antiepileptic drugs.
    The Japanese journal of psychiatry and neurology, 1990, Volume: 44, Issue:2

    Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Humans; Phen

1990
Phenytoin induced osteomalacia and fracture in a young epileptic.
    The Journal of the Association of Physicians of India, 1990, Volume: 38, Issue:9

    Topics: Adolescent; Epilepsy; Female; Femoral Neck Fractures; Humans; Osteomalacia; Phenytoin

1990
Postmortem serum protein binding and brain concentrations of antiepileptic drugs in autoptic specimens from 45 epileptic patients.
    Therapeutic drug monitoring, 1990, Volume: 12, Issue:6

    Topics: Anticonvulsants; Blood Proteins; Brain; Carbamazepine; Epilepsy; Female; Humans; Male; Phenobarbital

1990
[Blood levels of phenytoin. Pharmacokinetics and individualization of dosages in controlled children with crises and with persistence of crises].
    Boletin medico del Hospital Infantil de Mexico, 1990, Volume: 47, Issue:10

    Topics: Adolescent; Child; Epilepsy; Female; Humans; Male; Phenytoin

1990
Cognitive function in adult epileptic patients established on anticonvulsant monotherapy.
    Epilepsy research, 1990, Volume: 7, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cognition; Epilepsy; Female; Humans; Intelligence

1990
Plasma level distribution, effect and toxicity of antiepileptic drugs among Ethiopian epileptics.
    Ethiopian medical journal, 1990, Volume: 28, Issue:1

    Topics: Adolescent; Adult; Child; Drug Therapy, Combination; Epilepsy; Ethiopia; Female; Humans; Male; Pheno

1990
[Paroxysmal kinesigenic choreoathetosis: autonomic disease or reflex epilepsy?].
    Revue neurologique, 1990, Volume: 146, Issue:1

    Topics: Athetosis; Autonomic Nervous System Diseases; Child; Chorea; Diagnosis, Differential; Electroencepha

1990
Pharmacokinetics and safety of a phenytoin prodrug given i.v. or i.m. in patients.
    Neurology, 1990, Volume: 40, Issue:3 Pt 1

    Topics: Adult; Aged; Electrocardiography; Epilepsy; Female; Half-Life; Hemodynamics; Humans; Infusions, Intr

1990
[Therapeutic drug monitoring of phenytoin].
    Nihon rinsho. Japanese journal of clinical medicine, 1990, Volume: 48 Suppl

    Topics: Adolescent; Adult; Age Factors; Biological Availability; Child; Child, Preschool; Dosage Forms; Drug

1990
Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours.
    Acta neurochirurgica, 1990, Volume: 103, Issue:1-2

    Topics: Adult; Anticonvulsants; Brain Neoplasms; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged;

1990
Anticonvulsant effects of zonisamide and phenytoin on seizure activity of the feline visual cortex.
    Brain & development, 1990, Volume: 12, Issue:2

    Topics: Animals; Anticonvulsants; Cats; Dose-Response Relationship, Drug; Epilepsy; Female; Isoxazoles; Kind

1990
Serum protein binding of antiepileptic drugs in Sri Lankans.
    The Ceylon medical journal, 1990, Volume: 35, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Blood Proteins; Carbamazepine; Drug Therapy, Combination; Epilep

1990
Direct high-performance liquid chromatographic analysis of p-hydroxyphenyl-phenylhydantoin glucuronide, the final metabolite of phenytoin, in human serum and urine.
    Journal of chromatography, 1990, Apr-06, Volume: 526, Issue:2

    Topics: Chromatography, High Pressure Liquid; Epilepsy; Glucuronates; Glucuronidase; Humans; Phenytoin; Ster

1990
Treating epilepsy in Malawi: lessons learned.
    Tropical doctor, 1990, Volume: 20, Issue:2

    Topics: Adult; Child; Epilepsy; Follow-Up Studies; Humans; Malawi; Patient Education as Topic; Phenobarbital

1990
Monitoring of phenytoin in epileptic children: value of the single morning sample.
    Journal of neurology, 1990, Volume: 237, Issue:3

    Topics: Adolescent; Blood Specimen Collection; Child; Circadian Rhythm; Epilepsy; Humans; Monitoring, Physio

1990
Head circumference in children of epileptic mothers: contributions of drug exposure and genetic background.
    Epilepsy research, 1990, Volume: 5, Issue:3

    Topics: Adult; Anticonvulsants; Carbamazepine; Child, Preschool; Epilepsy; Female; Humans; Intelligence Test

1990
Pharmacokinetics of anticonvulsants in pregnancy: alterations in plasma protein binding.
    Epilepsy research, 1990, Volume: 5, Issue:3

    Topics: Adult; Anticonvulsants; Blood Proteins; Carbamazepine; Epilepsy; Female; Humans; Maternal-Fetal Exch

1990
A study of the interaction between omeprazole and phenytoin in epileptic patients.
    Therapeutic drug monitoring, 1990, Volume: 12, Issue:4

    Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Omeprazole; Phenytoin; Time F

1990
[Population kinetic program for Michaelis-Menten elimination].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:1

    Topics: Epilepsy; Humans; Phenytoin; Software

1990
Valproic acid and phenytoin effects on serum proteins and immunoglobulins of epileptic patients.
    General pharmacology, 1985, Volume: 16, Issue:4

    Topics: Adolescent; Adult; Aged; Alpha-Globulins; Beta-Globulins; Blood Proteins; Child; Child, Preschool; E

1985
Interaction between 8-methoxypsoralen and phenytoin. Consequence for PUVA therapy.
    Acta dermato-venereologica, 1985, Volume: 65, Issue:6

    Topics: Drug Interactions; Epilepsy; Female; Humans; Methoxsalen; Middle Aged; Phenytoin; Psoriasis; PUVA Th

1985
Intelligence of children of epileptic mothers.
    The Journal of pediatrics, 1988, Volume: 113, Issue:4

    Topics: Child, Preschool; Developmental Disabilities; Epilepsy; Female; Humans; Intelligence; Intelligence T

1988
Drugs for epilepsy.
    The Medical letter on drugs and therapeutics, 1989, Jan-13, Volume: 31, Issue:783

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Epilepsy; Humans; Phenytoin; Valpro

1989
Serum aspirin-esterase activity in epileptic patients receiving treatment with phenobarbital, phenytoin, carbamazepine and valproic acid.
    International journal of clinical pharmacology research, 1989, Volume: 9, Issue:1

    Topics: Adult; Anticonvulsants; Aspirin; Carbamazepine; Epilepsy; Esterases; Female; Humans; Male; Phenobarb

1989
IgG subclasses in epileptic patients treated with phenytoin.
    Journal of neurology, 1989, Volume: 236, Issue:3

    Topics: Adolescent; Adult; Antibodies, Monoclonal; Epilepsy; Humans; Immunoglobulin gamma-Chains; Immunoglob

1989
A model for managing epilepsy in a rural community in Africa.
    BMJ (Clinical research ed.), 1989, Mar-25, Volume: 298, Issue:6676

    Topics: Epilepsy; Health Education; Health Services Administration; Humans; Malawi; Mobile Health Units; Out

1989
Derivation and evaluation of an equation for prediction of free phenytoin concentration in patients co-medicated with valproic acid.
    Therapeutic drug monitoring, 1989, Volume: 11, Issue:2

    Topics: Adult; Aged; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Mathematics; Middle Aged; Ph

1989
Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:4

    Topics: Adolescent; Adult; Aged; Antipyrine; Caffeine; Carbamazepine; Cytochrome P-450 Enzyme System; Enzyme

1989
Thyroid hormone concentrations in epileptic patients.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Drug Combinations; Epilepsy; Humans; Phenytoin; Thyrotropin; Thyroxi

1989
Serum free levels and evaluation anticonvulsant drug interactions.
    Wisconsin medical journal, 1989, Volume: 88, Issue:12

    Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Valproi

1989
Probable pseudocholinesterase induction by valproic acid, carbamazepine and phenytoin leading to increased serum aspirin-esterase activity in epileptics.
    International journal of clinical pharmacology research, 1989, Volume: 9, Issue:5

    Topics: Adolescent; Adult; Analysis of Variance; Carbamazepine; Carboxylic Ester Hydrolases; Cholinesterases

1989
[Clinical study of gingival hyperplasia in epilepsy patient].
    Shigaku = Odontology; journal of Nihon Dental College, 1989, Volume: 77, Issue:4

    Topics: Adult; Dental Care for Disabled; Epilepsy; Gingival Hyperplasia; Gingivectomy; Humans; Phenytoin

1989
Axonal dystrophy in the posterior column nuclei of young adult epileptics with chronic phenytoin intoxication.
    The Japanese journal of psychiatry and neurology, 1989, Volume: 43, Issue:4

    Topics: Adult; Axons; Epilepsy; Female; Gliosis; Humans; Inclusion Bodies; Male; Medulla Oblongata; Neural P

1989
[The fetal hydantoin syndrome].
    Ugeskrift for laeger, 1989, Feb-27, Volume: 151, Issue:9

    Topics: Adult; Epilepsy; Female; Hand Deformities, Congenital; Humans; Hypospadias; Infant, Newborn; Male; M

1989
Clinical problems during the fast of Ramadan.
    Lancet (London, England), 1989, Apr-29, Volume: 1, Issue:8644

    Topics: Drug Therapy; Epilepsy; Fasting; Female; Humans; Islam; Male; Patient Compliance; Phenytoin

1989
Phenytoin and fasting.
    Lancet (London, England), 1989, May-27, Volume: 1, Issue:8648

    Topics: Drug Administration Schedule; Epilepsy; Fasting; Half-Life; Humans; Phenytoin

1989
Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices.
    Brain research, 1985, Jan-28, Volume: 325, Issue:1-2

    Topics: Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Cell Membrane Permeability; Epilepsy; Hipp

1985
Dosing accuracy of antiepileptic drug regimens as determined by serum concentrations in outpatient epilepsy clinic patients.
    Therapeutic drug monitoring, 1989, Volume: 11, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Outpatients; Phenobarbital; Phenytoin

1989
[The effect of vanillin on the fully amygdala-kindled seizures in the rat].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1989, Volume: 24, Issue:7

    Topics: Amygdala; Animals; Anticonvulsants; Benzaldehydes; Disease Models, Animal; Epilepsy; Female; Kindlin

1989
Serum immunoglobulins, complement levels and lymphocyte subpopulations in phenytoin-treated epileptic patients.
    Immunopharmacology and immunotoxicology, 1989, Volume: 11, Issue:2-3

    Topics: Adolescent; Adult; Antibodies, Monoclonal; Antibody Formation; Complement C3c; Complement C4; Comple

1989
Level dose ratio and the threshold of intoxication level by dosages of three different phenytoin preparations.
    The Japanese journal of psychiatry and neurology, 1989, Volume: 43, Issue:3

    Topics: Dose-Response Relationship, Drug; Epilepsy; Humans; Phenytoin

1989
[A 11-year-old boy of idiopathic accelerated idioventricular rhythm].
    Journal of cardiology. Supplement, 1989, Volume: 22

    Topics: Age Factors; Arrhythmias, Cardiac; Child; Echocardiography; Electrocardiography; Epilepsy; Humans; M

1989
Daily salivary anticonvulsant monitoring in patients with intractable epilepsy.
    Clinical and experimental neurology, 1989, Volume: 26

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Monitoring, Physiologic; Phenobarbi

1989
Cancer among epileptic patients exposed to anticonvulsant drugs.
    Journal of the National Cancer Institute, 1989, May-10, Volume: 81, Issue:10

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Brain Neoplasms; Child; Child, Preschool; Denmark;

1989
[Epileptic seizures in patients with a cerebrovascular infarction].
    Schweizerische medizinische Wochenschrift, 1989, Apr-22, Volume: 119, Issue:16

    Topics: Adult; Aged; Aged, 80 and over; Cerebral Infarction; Electroencephalography; Epilepsy; Female; Human

1989
Clinical and EEG response to anticonvulsants in neonatal seizures.
    Archives of disease in childhood, 1989, Volume: 64, Issue:4 Spec No

    Topics: Anticonvulsants; Diazepam; Electroencephalography; Epilepsy; Humans; Infant, Newborn; Paraldehyde; P

1989
Phenytoin withdrawal and seizure frequency.
    Neurology, 1989, Volume: 39, Issue:7

    Topics: Adult; Carbamazepine; Diazepam; Drug Therapy, Combination; Epilepsy; Epilepsy, Temporal Lobe; Female

1989
Determination of enzyme or binding constants using generalized linear models, with particular reference to Michaelis-Menten models.
    Journal of pharmaceutical sciences, 1989, Volume: 78, Issue:5

    Topics: Adult; Enzymes; Epilepsy; Female; Humans; Models, Biological; Pharmacokinetics; Phenytoin; Pregnancy

1989
Pregnancy and epilepsy.
    Journal of neurology, 1989, Volume: 236, Issue:5

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Estrogens; Female; Hum

1989
The effect of anticonvulsants on the dexamethasone suppression test.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1989, Volume: 34, Issue:5

    Topics: Adult; Anticonvulsants; Bipolar Disorder; Carbamazepine; Depressive Disorder; Dexamethasone; Epileps

1989
Pharmacology of ACC-9653 (phenytoin prodrug).
    Epilepsia, 1989, Volume: 30 Suppl 2

    Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Epilepsy; Heart Rate; Mice; Phenytoin; Prodrugs

1989
Role of the cerebellum in complex human behavior.
    Italian journal of neurological sciences, 1989, Volume: 10, Issue:3

    Topics: Adult; Atrophy; Behavior; Cerebellum; Cognition Disorders; Epilepsy; Humans; Intelligence Tests; Neu

1989
Modelling medical decision-making under uncertainty.
    The British journal of educational psychology, 1989, Volume: 59 ( Pt 2)

    Topics: Decision Making; Drug Therapy, Computer-Assisted; Education, Medical; Epilepsy; Humans; Phenytoin; T

1989
Serum 5'-nucleotidase in patients receiving anti-epileptic drugs.
    American journal of clinical pathology, 1985, Volume: 84, Issue:2

    Topics: 5'-Nucleotidase; Adolescent; Adult; Age Factors; Aged; Alkaline Phosphatase; Carbamazepine; Child; C

1985
Genetic predisposition to phenytoin-induced birth defects.
    Lancet (London, England), 1985, Oct-05, Volume: 2, Issue:8458

    Topics: Abnormalities, Multiple; Child; Epilepsy; Female; Humans; Phenytoin; Pregnancy

1985
Factors that affect the induction of gamma glutamyltransferase in epileptic patients receiving anti-convulsant drugs.
    Annals of clinical biochemistry, 1987, Volume: 24 ( Pt 4)

    Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Dose-Response Relationship, Drug; Dru

1987
Gastritis with valproate therapy.
    Archives of neurology, 1988, Volume: 45, Issue:8

    Topics: Adolescent; Antacids; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy;

1988
The influence of long-term anticonvulsant therapy with diphenylhydantoin and carbamazepine on serum gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase.
    European archives of psychiatry and neurological sciences, 1988, Volume: 237, Issue:5

    Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Carbamazepine; Chemi

1988
[Some experience in antiepileptic treatment drugs monitoring in clinic].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1988, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Temazepam

1988
[Altered gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase serum activities in long-term anticonvulsive therapy--comparison of diphenylhydantoin and carbamazepine].
    Wiener klinische Wochenschrift, 1988, Oct-21, Volume: 100, Issue:20

    Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Carbamazepine; Cytoc

1988
Effect of source of population data on phenytoin dosage predictions in black patients.
    Clinical pharmacy, 1989, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Aged; Bayes Theorem; Black People; Epilepsy; Europe; Feedback; Humans; Male; Midd

1989
[Epileptics and their oral health].
    Shiyo. The journal of the Tokyo Dental Association, 1985, Volume: 33, Issue:10

    Topics: Dental Care for Disabled; Epilepsy; Female; Gingival Hyperplasia; Humans; Male; Phenytoin

1985
[Epileptic patients in dental treatment].
    Dental Cadmos, 1986, Oct-15, Volume: 54, Issue:15

    Topics: Adolescent; Adult; Anesthesia, Dental; Anesthesia, Local; Dental Care for Disabled; Epilepsy; Female

1986
Development of phenytoin-induced gingival overgrowth in non-institutionalized epileptic children subjected to different plaque control programs.
    Acta odontologica Scandinavica, 1987, Volume: 45, Issue:2

    Topics: Adolescent; Child; Dental Care for Disabled; Dental Plaque; Dental Plaque Index; Epilepsy; Female; G

1987
[Convulsive attacks and the dentist].
    Actualites odonto-stomatologiques, 1988, Issue:161

    Topics: Adolescent; Child; Child, Preschool; Dental Care for Disabled; Diazepam; Emergencies; Epilepsy; Ging

1988
Different actions of vitamin D2 and D3 on bone metabolism in patients treated with phenobarbitone/phenytoin.
    Calcified tissue international, 1985, Volume: 37, Issue:3

    Topics: Adult; Alkaline Phosphatase; Bone and Bones; Calcium; Cholecalciferol; Double-Blind Method; Epilepsy

1985
Different metabolism of vitamin D2/D3 in epileptic patients treated with phenobarbitone/phenytoin.
    Bone, 1986, Volume: 7, Issue:5

    Topics: 24,25-Dihydroxyvitamin D 3; 25-Hydroxyvitamin D 2; Adult; Aged; Calcifediol; Calcium; Cholecalcifero

1986
Impact of a pharmacokinetics consultation service on clinical outcomes in an ambulatory-care epilepsy clinic.
    American journal of hospital pharmacy, 1988, Volume: 45, Issue:7

    Topics: Carbamazepine; Epilepsy; Humans; Immunoenzyme Techniques; Outpatient Clinics, Hospital; Pharmacology

1988
Carbamazepine, phenytoin and sodium valproate monotherapy.
    Journal of neurology, neurosurgery, and psychiatry, 1986, Volume: 49, Issue:3

    Topics: Carbamazepine; Epilepsy; Humans; Phenytoin; Valproic Acid

1986
Antiepileptic effects of globulin-N, an intact human immunoglobulin and its tissue-distribution in kindled cats.
    International journal of clinical pharmacology, therapy, and toxicology, 1986, Volume: 24, Issue:3

    Topics: Amygdala; Animals; Anticonvulsants; Autoradiography; Cats; Drug Combinations; Epilepsy; Half-Life; I

1986
The influence of seizure type and medication on psychiatric symptoms in epileptic patients.
    The British journal of psychiatry : the journal of mental science, 1986, Volume: 148

    Topics: Adult; Anticonvulsants; Attention; Carbamazepine; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Tempora

1986
Enhanced metabolism of levonorgestrel during phenytoin treatment in a woman with Norplant implants.
    Contraception, 1986, Volume: 33, Issue:3

    Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Kinetics; Levonorgestrel; Menstruation; Norgestr

1986
Phenylethylmalonamide serum levels in patients treated with primidone and the effects of other antiepileptic drugs.
    Therapeutic drug monitoring, 1986, Volume: 8, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Malonates; Phenobarbita

1986
Drugs for epilepsy.
    The Medical letter on drugs and therapeutics, 1986, Sep-26, Volume: 28, Issue:723

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Epilepsy; Humans; Phenytoin; Status

1986
A comparative study of the relative influence of different anticonvulsant drugs, UV exposure and diet on vitamin D and calcium metabolism in out-patients with epilepsy.
    The Quarterly journal of medicine, 1986, Volume: 59, Issue:230

    Topics: Adult; Calcium; Carbamazepine; Diet; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Ultra

1986
[Various matters concerning the improvement of therapeutic tactics in epilepsy].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1986, Volume: 86, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Drug Therapy, Comb

1986
[Rational phenytoin therapy: a method for individualizing dosage].
    Zhonghua yi xue za zhi, 1986, Volume: 66, Issue:3

    Topics: Adolescent; Adult; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Kinetics; Male

1986
[Relation between serum IgA and HLA in patients with epilepsy].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1986, Volume: 19, Issue:4

    Topics: Adult; Epilepsy; Epilepsy, Tonic-Clonic; Female; HLA Antigens; HLA-A2 Antigen; Humans; Immunoglobuli

1986
Memory disturbances in epileptic patients.
    Acta neurologica Scandinavica. Supplementum, 1986, Volume: 109

    Topics: Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Memory Disorders; Phenytoin; Valproic Ac

1986
Synergistic effects of oxiracetam and piracetam in combination with antiepileptic drugs.
    Acta neurologica Scandinavica. Supplementum, 1986, Volume: 109

    Topics: Animals; Anticonvulsants; Carbamazepine; Clonazepam; Drug Synergism; Drug Therapy, Combination; Epil

1986
Gynaecomastia induced by phenytoin in men with epilepsy.
    British medical journal (Clinical research ed.), 1987, Mar-07, Volume: 294, Issue:6572

    Topics: Adult; Epilepsy; Gonadotropins; Gynecomastia; Humans; Male; Phenytoin; Steroids

1987
Barbiturate-refractory epilepsy: safe schedule for therapeutic substitution.
    Arquivos de neuro-psiquiatria, 1986, Volume: 44, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Carbamazepine; Drug Tolerance; Epilepsy; Female; H

1986
Anticonvulsant drugs in monotherapy. Effect on the fetus.
    European journal of epidemiology, 1987, Volume: 3, Issue:2

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fe

1987
Concurrent lupus anticoagulants and prothrombin deficiency due to phenytoin use.
    Archives of pathology & laboratory medicine, 1987, Volume: 111, Issue:8

    Topics: Adult; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Coagulation Tests; Epilepsy; Hu

1987
[Cognitive effects of antiepileptic drugs].
    Revue neurologique, 1987, Volume: 143, Issue:5

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cognition Disorders; Epilepsy;

1987
An interaction between cytostatic and anticonvulsant drugs.
    Clinical pharmacology and therapeutics, 1988, Volume: 43, Issue:4

    Topics: Adenocarcinoma, Papillary; Adult; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carba

1988
The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic.
    Postgraduate medical journal, 1987, Volume: 63, Issue:744

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Midd

1987
Adrenal cortex hormones in male epileptic patients before and during a 2-year phenytoin treatment.
    Journal of neurology, neurosurgery, and psychiatry, 1988, Volume: 51, Issue:3

    Topics: 17-Hydroxycorticosteroids; Adrenal Cortex; Adrenal Cortex Hormones; Adult; Epilepsies, Partial; Epil

1988
[Ultrastructural study on phenytoin-induced gingival proliferation].
    Zhonghua yi xue za zhi, 1988, Volume: 68, Issue:1

    Topics: Adolescent; Epilepsy; Gingiva; Gingival Hyperplasia; Humans; Male; Phenytoin

1988
Delayed bone development in epileptic children assessed by microdensitometer.
    Developmental pharmacology and therapeutics, 1988, Volume: 11, Issue:1

    Topics: Adolescent; Anticonvulsants; Bone Development; Calcifediol; Calcitriol; Child; Child, Preschool; Den

1988
A comparative study of the relative effects of anticonvulsant drugs and dietary folate on the red cell folate status of patients with epilepsy.
    The Quarterly journal of medicine, 1987, Volume: 65, Issue:247

    Topics: Adult; Anticonvulsants; Carbamazepine; Diet; Drug Therapy, Combination; Epilepsy; Erythrocytes; Fema

1987
Predictability of unbound antiepileptic drug concentrations in children treated with valproic acid and phenytoin.
    Clinical pharmacy, 1988, Volume: 7, Issue:9

    Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Phenytoin; Prote

1988
Variability of phenytoin, carbamazepine and valproate concentrations in a clinic population.
    Epilepsy research. Supplement, 1988, Volume: 1

    Topics: Carbamazepine; Epilepsy; Female; Humans; Male; Minnesota; Outpatient Clinics, Hospital; Patient Comp

1988
[Clinical treatment of resistant epilepsy].
    Arquivos de neuro-psiquiatria, 1988, Volume: 46, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Resistance; Electroencephalography; E

1988
Changes in clearance of sodium valproate with changes in dose.
    Clinical and experimental neurology, 1987, Volume: 24

    Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; M

1987
Altered phenytoin clearance during intensive chemotherapy for acute lymphoblastic leukemia.
    The Journal of pediatrics, 1988, Volume: 112, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Epilepsy; Humans; Leukemia, Lymphoid; Male; M

1988
Phenytoin-induced resistance to pancuronium. Use of atracurium infusion in management of a neurosurgical patient.
    Anaesthesia, 1988, Volume: 43, Issue:9

    Topics: Adolescent; Atracurium; Brain Neoplasms; Drug Interactions; Drug Tolerance; Epilepsy; Humans; Infusi

1988
Gingival hyperplasia of an edentulous alveolar ridge in an epileptic--a case report.
    The New Zealand dental journal, 1988, Volume: 84, Issue:378

    Topics: Adult; Denture, Partial, Removable; Epilepsy; Female; Gingival Hyperplasia; Humans; Jaw, Edentulous,

1988
Are phenobarbital and phenytoin obsolete in the treatment of epilepsy?
    The Journal of the Association of Physicians of India, 1988, Volume: 36, Issue:7

    Topics: Epilepsy; Humans; Phenobarbital; Phenytoin

1988
Long-term use of phenytoin: effect on haematological parameters in Nigerian epileptics.
    The Central African journal of medicine, 1988, Volume: 34, Issue:2

    Topics: Adolescent; Adult; Child; Epilepsy; Erythrocyte Indices; Female; Folic Acid; Hematocrit; Hematologic

1988
Relevance of poor compliance for seizure control.
    Epilepsy research. Supplement, 1988, Volume: 1

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Middle Aged; Patient Compliance

1988
Comparative determination of phenytoin in plasma by fluorescence polarization immunoassay and high performance liquid chromatography.
    Drug design and delivery, 1987, Volume: 2, Issue:1

    Topics: Chromatography, High Pressure Liquid; Epilepsy; Fluorescent Antibody Technique; Humans; Phenytoin; R

1987
Fatal paracetamol poisoning in an epileptic.
    Human toxicology, 1988, Volume: 7, Issue:1

    Topics: Acetaminophen; Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clobazam; Cytochrome

1988
Minor anomalies in offspring of epileptic mothers.
    The Journal of pediatrics, 1988, Volume: 112, Issue:4

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Child; Child, Preschool; Congenital Abnormalities; E

1988
Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics.
    Neurology, 1988, Volume: 38, Issue:4

    Topics: Adult; Aged; Epilepsy; Humans; Male; Middle Aged; Phenobarbital; Phenytoin

1988
Phenytoin toxicity causing priapism.
    British journal of urology, 1988, Volume: 61, Issue:3

    Topics: Adult; Epilepsy; Humans; Male; Phenytoin; Priapism

1988
Plasma and urinary taurine in epilepsy.
    Clinical chemistry, 1988, Volume: 34, Issue:4

    Topics: Anticonvulsants; Electroencephalography; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; T

1988
Phenytoin-induced gum hypertrophy in patients with epilepsy.
    Current medical research and opinion, 1988, Volume: 10, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Drug Therapy, Combination; Epilepsy; Female; Ging

1988
[Visual disorders caused by diphenylhydantoin: clinical and electro-ophthalmologic findings].
    Klinische Monatsblatter fur Augenheilkunde, 1988, Volume: 192, Issue:3

    Topics: Electrooculography; Electroretinography; Epilepsy; Evoked Potentials, Visual; Female; Fluorescein An

1988
Is free fraction measurement of phenytoin always necessary in pediatric epileptic patients?
    Therapeutic drug monitoring, 1988, Volume: 10, Issue:1

    Topics: Adolescent; Age Factors; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Monitoring

1988
Evaluation of serum phenytoin monitoring in an acute care setting.
    Therapeutic drug monitoring, 1988, Volume: 10, Issue:1

    Topics: Acute Disease; Adult; Dose-Response Relationship, Drug; Epilepsy; Female; Hospitals, Teaching; Human

1988
Comparison of a Bayesian forecasting technique with a new method for estimating phenytoin dose requirements.
    Therapeutic drug monitoring, 1988, Volume: 10, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Bayes Theorem; Epilepsy; Female; Humans; Male; Mathematics; Methods;

1988
Onychopathy in a patient with fetal hydantoin syndrome.
    Pediatric dermatology, 1988, Volume: 5, Issue:1

    Topics: Epilepsy; Female; Humans; Infant; Nail Diseases; Nails; Phenytoin; Pregnancy; Pregnancy Complication

1988
Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance.
    Neurology, 1988, Volume: 38, Issue:7

    Topics: Adult; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Male; Middle Aged; Phenytoin; Tim

1988
Corticosteroid-unresponsive pemphigus vulgaris following antiepileptic therapy.
    International journal of dermatology, 1988, Volume: 27, Issue:4

    Topics: Adult; Drug Interactions; Epilepsy; Humans; Male; Pemphigus; Phenobarbital; Phenytoin; Prednisolone;

1988
Carbamazepine and phenytoin. Comparison of cognitive effects in epileptic patients during monotherapy and withdrawal.
    Archives of neurology, 1988, Volume: 45, Issue:8

    Topics: Carbamazepine; Cognition; Epilepsy; Humans; Intelligence Tests; Neuropsychological Tests; Phenytoin

1988
[Loading-doses of carbamazepine and diphenylhydantoin: use in high-risk patients].
    Arquivos de neuro-psiquiatria, 1987, Volume: 45, Issue:3

    Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsy; Humans; Middle Aged; Phenytoin; Risk

1987
[Cursive and gelastic manifestations of epilepsies].
    Arquivos de neuro-psiquiatria, 1987, Volume: 45, Issue:4

    Topics: Adolescent; Adult; Carbamazepine; Child; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe;

1987
[Clinical course and histological evaluation of hydantoin-induced gingival hyperplasia].
    Fogorvosi szemle, 1986, Volume: 79, Issue:4

    Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Gingival Hyperplasia; Humans; Phenytoin

1986
Oral health in non-institutionalized epileptic children with special reference to phenytoin medication.
    Community dentistry and oral epidemiology, 1986, Volume: 14, Issue:3

    Topics: Adolescent; Ambulatory Care; Child; Dental Caries; DMF Index; Epilepsy; Female; Humans; Male; Oral H

1986
Putnam, Merritt, and the discovery of Dilantin.
    Epilepsia, 1986, Volume: 27 Suppl 3

    Topics: Animals; Anticonvulsants; Boston; Epilepsy; History, 19th Century; History, 20th Century; Humans; Ph

1986
[Diphenylhydantoin and primary hypothyroidism].
    Revista clinica espanola, 1986, Volume: 179, Issue:8

    Topics: Epilepsy; Female; Humans; Hypothyroidism; Middle Aged; Phenytoin

1986
Factors influencing the optimisation of phenytoin therapy in epileptic paediatric patients.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1987, Apr-04, Volume: 71, Issue:7

    Topics: Child; Epilepsy; Humans; Phenytoin

1987
Stereochemistry of aromatic phenytoin hydroxylation in various drug hydroxylation phenotypes in humans.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2

    Topics: Adult; Chromatography, High Pressure Liquid; Epilepsy; Epoxy Compounds; Female; Glucuronates; Humans

1987
Minor additive inducing effects of phenobarbital on carbamazepine clearance in patients on combined carbamazepine-phenytoin therapy.
    Therapeutic drug monitoring, 1987, Volume: 9, Issue:1

    Topics: Aged; Carbamazepine; Drug Interactions; Epilepsy; Humans; Male; Middle Aged; Phenobarbital; Phenytoi

1987
Transient global amnesia and epilepsy. Electroencephalographic distinction.
    Archives of neurology, 1987, Volume: 44, Issue:6

    Topics: Amnesia; Electroencephalography; Epilepsy; Humans; Male; Middle Aged; Phenytoin

1987
[Electrophysiologic changes after taking sodium phenytoin].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1986, Volume: 19, Issue:6

    Topics: Adult; Alpha Rhythm; Epilepsy; Female; Humans; Male; Neural Conduction; Phenytoin

1986
Cognitive effects of phenytoin during monotherapy and after withdrawal.
    Acta neurologica Scandinavica, 1987, Volume: 75, Issue:4

    Topics: Adult; Attention; Cognition; Epilepsy; Humans; Middle Aged; Neuropsychological Tests; Phenytoin; Psy

1987
Monitoring of drug therapy in epileptic children.
    International journal of clinical pharmacology, therapy, and toxicology, 1987, Volume: 25, Issue:5

    Topics: Child; Epilepsy; Humans; Monitoring, Physiologic; Phenobarbital; Phenytoin

1987
Phenytoin and carbamazepine, alone and in combination: anticonvulsant and neurotoxic effects.
    Neurology, 1987, Volume: 37, Issue:7

    Topics: Animals; Brain; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Co

1987
Population pharmacokinetics of phenytoin in South African black patients.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1987, Aug-01, Volume: 72, Issue:3

    Topics: Adolescent; Adult; Black People; Child; Epilepsy; Female; Humans; Kinetics; Male; Middle Aged; Pheny

1987
Desipramine and phenytoin: a potential drug interaction of therapeutic relevance.
    The Journal of clinical psychiatry, 1987, Volume: 48, Issue:9

    Topics: Adult; Depressive Disorder; Desipramine; Drug Interactions; Epilepsy; Female; Humans; Male; Phenytoi

1987
Folate metabolism and problem behaviour in mentally handicapped epileptics.
    Journal of mental deficiency research, 1987, Volume: 31 ( Pt 2)

    Topics: Adolescent; Adult; Aged; Epilepsy; Female; Folic Acid; Humans; Intellectual Disability; Male; Mental

1987
Serum phenytoin during pregnancy, labor and puerperium.
    Acta neurologica Scandinavica, 1987, Volume: 75, Issue:6

    Topics: Adult; Epilepsy; Female; Humans; Labor, Obstetric; Osmolar Concentration; Phenytoin; Postpartum Peri

1987
Your CE topic this month (No. 20). Antiepileptic pharmacotherapy.
    The Journal of practical nursing, 1986, Volume: 36, Issue:5

    Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Humans; Nu

1986
Development of presenile cataracts in association with high serum levels of phenytoin.
    Annals of ophthalmology, 1987, Volume: 19, Issue:8

    Topics: Adult; Cataract; Epilepsy; Humans; Male; Phenytoin

1987
Kindling models and antikindling effects of mood normalizers.
    Pharmacopsychiatry, 1987, Volume: 20, Issue:5

    Topics: Animals; Cats; Diethylcarbamazine; Electric Stimulation; Epilepsy; Humans; Kindling, Neurologic; Lit

1987
Utilization of Km for phenytoin dosage after folate addition to patient regimen.
    Therapeutic drug monitoring, 1987, Volume: 9, Issue:3

    Topics: Adult; Aged; Epilepsy; Folic Acid; Humans; Male; Middle Aged; Phenytoin

1987
Response of polygraphic sleep to phenytoin treatment for epilepsy. A longitudinal study of immediate, short- and long-term effects.
    Acta neurologica Scandinavica, 1987, Volume: 76, Issue:3

    Topics: Adult; Epilepsy; Female; Humans; Longitudinal Studies; Phenytoin; Sleep; Sleep, REM; Time Factors

1987
Spread and arrest of seizures: the importance of layer 4 in laminar interactions during neocortical epileptogenesis.
    Advances in neurology, 1986, Volume: 44

    Topics: Action Potentials; Animals; Anticonvulsants; Bicuculline; Biomechanical Phenomena; Cats; Cerebral Co

1986
Prevalence of toxic anticonvulsant drug concentrations in mentally retarded persons with epilepsy.
    American journal of mental deficiency, 1986, Volume: 90, Issue:6

    Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Intellectual Disability; Kinetics; Male; Phenytoin;

1986
Does prolonged use of diphenylhydantoin predispose to pulmonary sarcoidosis?
    European neurology, 1986, Volume: 25, Issue:4

    Topics: Adult; Epilepsy; Female; Humans; Immunoglobulins; Lung Diseases; Lymphocyte Activation; Lymphocytes;

1986
Measuring anti-convulsant levels in the accident and emergency department.
    Archives of emergency medicine, 1986, Volume: 3, Issue:2

    Topics: Adult; Carbamazepine; Emergencies; Epilepsy; Humans; Patient Compliance; Phenobarbital; Phenytoin; P

1986
Assessment of polymorphonucleate leucocyte functions in adult epileptic patients undergoing long-term phenytoin treatment.
    Human toxicology, 1986, Volume: 5, Issue:4

    Topics: Adult; Aged; Chemotaxis, Leukocyte; Epilepsy; Female; Humans; Leukocyte Count; Male; Middle Aged; Ne

1986
Decision-making in refractory epilepsy: an analysis based on computer simulation.
    Journal of neurology, neurosurgery, and psychiatry, 1986, Volume: 49, Issue:7

    Topics: Carbamazepine; Computers; Epilepsy; Humans; Models, Theoretical; Patient Compliance; Phenytoin

1986
Comparative pharmacokinetics of zonisamide (CI-912) in epileptic patients on carbamazepine or phenytoin monotherapy.
    Therapeutic drug monitoring, 1986, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Body Weight; Carbamazepine; Drug Therapy, Combination; Epilepsy;

1986
[Phenomenon of "paradoxical poisoning" during antiepileptic therapy].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1986, Volume: 86, Issue:6

    Topics: Adult; Anticonvulsants; Barbiturates; Carbamazepine; Child; Drug Synergism; Drug Therapy, Combinatio

1986
[Concentration of benzonal in the blood of epileptic patients at different daily doses and with other anticonvulsants].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1986, Volume: 86, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Benzamidines; Epilepsy; Female; Humans; Male; Phen

1986
Interaction of dietary pudding with phenytoin.
    Pediatrics, 1986, Volume: 78, Issue:5

    Topics: Adolescent; Adult; Child; Drug Interactions; Epilepsy; Female; Food, Formulated; Humans; Male; Middl

1986
[Drug interactions with phenytoin and carbamazepine].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1986, Volume: 88, Issue:4

    Topics: Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin

1986
[Determination of sodium phenytoin concentration in the blood by radioimmunologic PEG].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1986, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Radioimmunoassay

1986
Epilepsy and pregnancy.
    American family physician, 1986, Volume: 34, Issue:5

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant Care; Infant, Newborn

1986
Effect of influenza vaccine on serum anticonvulsant concentrations.
    Clinical pharmacy, 1986, Volume: 5, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Influenza Vaccines; Inf

1986
Epilepsy after operation for aneurysms.
    Neurosurgery, 1986, Volume: 19, Issue:5

    Topics: Craniotomy; Epilepsy; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Phenytoin; Postopera

1986
Developmental effects of anticonvulsants.
    Neurotoxicology, 1986,Summer, Volume: 7, Issue:2

    Topics: Animals; Anticonvulsants; Body Weight; Epilepsy; Female; Fetal Diseases; Humans; Motor Activity; Phe

1986
Phenytoin kinetics during pregnancy and the puerperium.
    British journal of obstetrics and gynaecology, 1986, Volume: 93, Issue:10

    Topics: Adult; Epilepsy; Female; Fetal Blood; Humans; Kinetics; Phenytoin; Postpartum Period; Pregnancy; Pre

1986
Phenytoin vs carbamazepine in seizure disorder.
    The Journal of the Association of Physicians of India, 1986, Volume: 34, Issue:8

    Topics: Carbamazepine; Epilepsy; Humans; Phenytoin

1986
Effect of simultaneously ingested milk on phenytoin bioavailability.
    Neurology, 1985, Volume: 35, Issue:10

    Topics: Adult; Aged; Animals; Biological Availability; Epilepsy; Humans; Male; Middle Aged; Milk; Phenytoin;

1985
Availability of drug assay results and dosage advice improves antiepileptic care in a specialist neurology outpatient clinic.
    Clinical and experimental neurology, 1985, Volume: 21

    Topics: Adolescent; Adult; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Humans; Outpatient Cli

1985
Studies of qingyangshen (root of Cynanchum otophyllum). I. Effect of qingyangshen on copper and zinc metabolism.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 1985, Volume: 5, Issue:2

    Topics: Animals; Anticonvulsants; Copper; Drugs, Chinese Herbal; Epilepsy; Medicine, Chinese Traditional; Me

1985
The effects of long-term anticonvulsant drug therapy on vitamin D metabolites and mineral homeostasis in pregnant epileptic women and their newborns.
    Annales chirurgiae et gynaecologiae. Supplementum, 1985, Volume: 197

    Topics: Adolescent; Adult; Anticonvulsants; Calcifediol; Calcitriol; Carbamazepine; Dihydroxycholecalciferol

1985
Effect of chronic anticonvulsant monotherapy on lymphocyte subpopulations in adult epileptic patients.
    Human toxicology, 1985, Volume: 4, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Complement System Proteins; Epilepsy; Femal

1985
Examination of infants for both minor and major malformations to evaluate for possible teratogenic exposures.
    Progress in clinical and biological research, 1985, Volume: 163B

    Topics: Abnormalities, Drug-Induced; Diabetes Mellitus, Type 1; Epilepsy; Female; Gonadal Steroid Hormones;

1985
Isolated malignant lymphoma of the jejunum and long-term diphenylhydantoin therapy.
    Oncology, 1985, Volume: 42, Issue:2

    Topics: Aged; Epilepsy; Humans; Jejunal Neoplasms; Lymphoma, Large B-Cell, Diffuse; Male; Phenytoin; Time Fa

1985
Ultrafiltration compared with equilibrium dialysis in the determination of unbound phenytoin in plasma.
    Therapeutic drug monitoring, 1985, Volume: 7, Issue:4

    Topics: Blood Proteins; Dialysis; Epilepsy; Humans; Immunoenzyme Techniques; Phenytoin; Protein Binding; Ult

1985
[Side effects of anticonvulsants on the peripheral nervous system and vestibulo-ocular functions].
    Fortschritte der Neurologie-Psychiatrie, 1985, Volume: 53, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Epilepsy, Temporal Lobe;

1985
Time-dependent interaction between phenytoin and valproic acid.
    Neurology, 1985, Volume: 35, Issue:4

    Topics: Adolescent; Adult; Child; Child, Preschool; Circadian Rhythm; Drug Interactions; Drug Therapy, Combi

1985
[Acute liver necrosis caused by valproate].
    Deutsche medizinische Wochenschrift (1946), 1985, Jun-14, Volume: 110, Issue:24

    Topics: Adult; Creatine Kinase; Epilepsy; Female; Humans; Liver Cirrhosis; Phenytoin; Transaminases; Valproi

1985
Effects of pregnancy on antiepileptic drug utilization.
    Epilepsia, 1985, Volume: 26 Suppl 1

    Topics: Anticonvulsants; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Kinetics; Metabol

1985
Adaptation of hepatic ammonia metabolism after chronic valproate administration in epileptics treated with phenytoin.
    European neurology, 1985, Volume: 24, Issue:3

    Topics: Adaptation, Physiological; Adult; Ammonia; Drug Interactions; Drug Therapy, Combination; Epilepsy; H

1985
Anticonvulsant drugs and the genetically epilepsy-prone rat.
    Federation proceedings, 1985, Volume: 44, Issue:10

    Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M

1985
The effects of phenytoin and sodium valproate on the periodontal health of adult epileptic patients.
    Journal of clinical periodontology, 1985, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Aged; Alveolar Process; Bone Resorption; Cross-Sectional Studies; Dental Plaque I

1985
Drug compliance and seizure control in epileptic children.
    Postgraduate medical journal, 1985, Volume: 61, Issue:715

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infan

1985
Monotherapy and polytherapy for intractable epilepsies.
    Italian journal of neurological sciences, 1985, Volume: 6, Issue:2

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clobazam; D

1985
Interictal EEG prediction of response to antiepileptic drug monotherapy.
    Clinical EEG (electroencephalography), 1985, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Electroencephalogr

1985
Evaluation of the effects of antiepileptic drugs on sleep-wakefulness patterns following 1 night total sleep deprivation in epileptic patients.
    Neuropsychobiology, 1985, Volume: 13, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Human

1985
Chronic valproic acid therapy and incidence of increases in venous plasma ammonia.
    Therapeutic drug monitoring, 1985, Volume: 7, Issue:3

    Topics: Adolescent; Adult; Aged; Ammonia; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epileps

1985
The optimum use of anticonvulsants.
    The Practitioner, 1985, Volume: 229, Issue:1408

    Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phen

1985
Mortality from ischaemic heart disease among patients using anticonvulsive drugs: a case-control study.
    British medical journal (Clinical research ed.), 1985, Nov-23, Volume: 291, Issue:6507

    Topics: Aged; Anticonvulsants; Barbiturates; Carbamazepine; Cardiovascular Diseases; Cerebrovascular Disorde

1985
Where, why, and what type of therapy.
    Pediatric annals, 1985, Volume: 14, Issue:11

    Topics: Carbamazepine; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Hum

1985
Monitoring: the most important role of the pediatrician.
    Pediatric annals, 1985, Volume: 14, Issue:11

    Topics: Activities of Daily Living; Anticonvulsants; Carbamazepine; Child, Preschool; Environmental Monitori

1985
Serum concentrations of valproic acid: influence of dose and comedication.
    Therapeutic drug monitoring, 1985, Volume: 7, Issue:4

    Topics: Adolescent; Adult; Body Weight; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epileps

1985
Influence of anticonvulsant drugs on thyroid hormones in epileptic children.
    Acta paediatrica Hungarica, 1985, Volume: 26, Issue:4

    Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Mephenytoin; Phenytoin; Primidone; Thyro

1985
Use of total and free anticonvulsant serum levels in clinical practice.
    Clinical and experimental neurology, 1985, Volume: 21

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Immunoenzyme Techniques; Phenobarbital; Phenytoin;

1985
Alternative single anticonvulsant drug therapy for refractory epilepsy.
    Annals of neurology, 1986, Volume: 19, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Chronic Disease; Epilepsy; Humans; Phenobarbital; Phenytoin;

1986
The influence of seizure type on the efficacy of plasma concentrations of phenytoin, phenobarbital, and carbamazepine.
    Archives of neurology, 1986, Volume: 43, Issue:3

    Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin

1986
Maternal anticonvulsants and fetal hemorrhage. A report of two cases.
    The Journal of reproductive medicine, 1986, Volume: 31, Issue:1

    Topics: Adolescent; Adult; Cesarean Section; Epilepsy; Female; Fetal Diseases; Hemorrhage; Hemostasis; Human

1986
Ovarian hormones, anticonvulsant drugs, and seizures during the menstrual cycle in women with epilepsy.
    Journal of neurology, neurosurgery, and psychiatry, 1986, Volume: 49, Issue:1

    Topics: Adolescent; Adult; Epilepsy; Estradiol; Estriol; Estrone; Female; Gonadal Steroid Hormones; Humans;

1986
Behavioral and cognitive impairments in children with epilepsy: the long-term effects of anticonvulsant therapy.
    Journal of the American Academy of Child Psychiatry, 1985, Volume: 24, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Child Behavior Disorders; Child, Preschool; Electroencephalograp

1985
Hypothyroidism and phenytoin intoxication.
    Annals of internal medicine, 1985, Volume: 102, Issue:3

    Topics: Aged; Epilepsy; Female; Humans; Hypothyroidism; Phenytoin; Thyrotropin; Thyroxine

1985
Carbamazepine and carbamazepine-10,11-epoxide serum concentrations in epileptic children.
    The Journal of pediatrics, 1985, Volume: 106, Issue:3

    Topics: Adolescent; Age Factors; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy

1985
Thyroid function in epileptic mothers and their infants at birth.
    American journal of obstetrics and gynecology, 1985, Mar-01, Volume: 151, Issue:5

    Topics: Anticonvulsants; Epilepsy; Female; Fetal Blood; Humans; Infant, Newborn; Phenytoin; Pregnancy; Pregn

1985
Differential effect of cimetidine on serum concentrations of carbamazepine and phenytoin.
    Neurology, 1985, Volume: 35, Issue:4

    Topics: Adolescent; Adult; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Hu

1985
Anticonvulsant use during pregnancy.
    Clinical therapeutics, 1985, Volume: 7, Issue:2

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Death; Humans; Phenobarbital;

1985
Dosage of phenytoin during pregnancy.
    JAMA, 1985, May-17, Volume: 253, Issue:19

    Topics: Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications

1985
Carbamazepine-phenytoin interaction: elevation of plasma phenytoin concentrations due to carbamazepine comedication.
    Therapeutic drug monitoring, 1985, Volume: 7, Issue:1

    Topics: Adult; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Male;

1985
Steady-state serum levels of anticonvulsant drugs in Chinese epileptic patients living in Taiwan.
    Therapeutic drug monitoring, 1985, Volume: 7, Issue:1

    Topics: Adolescent; Adult; Age Factors; Asian People; Body Weight; Child; Epilepsy; Female; Humans; Male; Mi

1985
Bioavailability of phenytoin: comparison between three preparations.
    Israel journal of medical sciences, 1985, Volume: 21, Issue:4

    Topics: Adult; Biological Availability; Chemistry, Pharmaceutical; Dosage Forms; Epilepsy; Female; Humans; K

1985
CT findings following diphenylhydantoin intoxication.
    Pediatric radiology, 1985, Volume: 15, Issue:4

    Topics: Adult; Cerebellar Ataxia; Child; Epilepsy; Female; Humans; Phenytoin; Tomography, X-Ray Computed

1985
Epilepsy in a community--management and social impact.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1985, Jun-15, Volume: 67, Issue:24

    Topics: Adolescent; Adult; Aged; Ambulatory Care Facilities; Carbamazepine; Craniocerebral Trauma; Epilepsy;

1985
Effect of antiepileptic drugs on short-latency somatosensory evoked potentials.
    Acta neurologica Scandinavica, 1985, Volume: 71, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephal

1985
Gas chromatographic determination of m- and p-hydroxyphenytoin in the urine of epileptic patients.
    Journal of chromatography, 1985, May-03, Volume: 339, Issue:2

    Topics: Adult; Aged; Carbamazepine; Chromatography, Gas; Epilepsy; Female; Humans; Hydrolysis; Male; Phenyto

1985
Stable-isotope methodology for the bioavailability study of phenytoin during multiple-dosing regimens.
    Journal of pharmaceutical sciences, 1985, Volume: 74, Issue:5

    Topics: Adult; Biological Availability; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Ma

1985
Reversible chronic cerebellar ataxia after phenytoin intoxication: possible role of cerebellum in cognitive thought.
    Neurology, 1985, Volume: 35, Issue:8

    Topics: Adolescent; Cerebellar Ataxia; Cerebellum; Chronic Disease; Cognition; Electroencephalography; Elect

1985
Epileptic amnesic attacks: benefit from antiepileptic drugs.
    Neurology, 1985, Volume: 35, Issue:8

    Topics: Aged; Amnesia; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Male; Middle Aged; Neuropsychologic

1985
Damage of Purkinje cell axons following chronic phenytoin administration: an animal model of distal axonopathy.
    Acta neuropathologica, 1985, Volume: 67, Issue:1-2

    Topics: Animals; Axons; Central Nervous System Diseases; Disease Models, Animal; Epilepsy; Male; Mice; Mice,

1985
[The variability of plasma protein binding of phenytoin in epileptic patients with hypoalbuminemia].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1985, Volume: 105, Issue:5

    Topics: Adult; Aged; Blood Proteins; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Protein Binding

1985
The clinical value of free phenytoin levels.
    Annals of neurology, 1985, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Epilepsy; Humans; Middle Aged; Phenytoin

1985
Sister chromatid exchanges in adult epileptic patients on phenytoin therapy.
    Environmental mutagenesis, 1985, Volume: 7, Issue:5

    Topics: Adult; Epilepsy; Humans; Lymphocytes; Middle Aged; Mutation; Phenytoin; Sister Chromatid Exchange; T

1985
[Clinical significance of blood levels of diphenylhydantoin orally administered to epileptic patients].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1985, Volume: 18, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenyto

1985
[Anticonvulsive prophylaxis after juvenile craniocerebral injuries: a retrospective evaluation].
    Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood, 1985, Volume: 40, Issue:4

    Topics: Anticonvulsants; Brain Concussion; Child; Drug Therapy, Combination; Electroencephalography; Epileps

1985
[Diphenylhydantoin poisoning in monotherapy and in combination with other antiepileptic drugs].
    Arquivos de neuro-psiquiatria, 1985, Volume: 43, Issue:2

    Topics: Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin

1985
Increased frequency of goitre in epileptic patients on long-term phenytoin or carbamazepine treatment.
    Clinical endocrinology, 1985, Volume: 23, Issue:4

    Topics: Adolescent; Adult; Aged; Carbamazepine; Epilepsy; Female; Goiter; Humans; Male; Middle Aged; Phenyto

1985
Ambulatory cassette EEG in clinical practice.
    Neurology, 1985, Volume: 35, Issue:12

    Topics: Adolescent; Adult; Aged; Ambulatory Care; Child; Child, Preschool; Electroencephalography; Epilepsy;

1985
Incidence of seizures with phenytoin toxicity.
    Neurology, 1985, Volume: 35, Issue:12

    Topics: Adult; Epilepsy; Female; Humans; Infant; Male; Middle Aged; Phenytoin; Retrospective Studies; Seizur

1985
Prolactin and growth hormone dynamics in epileptic patients receiving phenytoin.
    Clinical endocrinology, 1985, Volume: 23, Issue:3

    Topics: Adolescent; Adult; Bromocriptine; Epilepsy; Female; Growth Hormone; Humans; Male; Metoclopramide; Mi

1985
[Macrocytic anemia due to folic acid deficiency and non-Hodgkin's lymphoma associated with prolonged diphenylhydantoin ingestion].
    Medicina clinica, 1985, Oct-19, Volume: 85, Issue:12

    Topics: Aged; Anemia, Macrocytic; Epilepsy; Female; Folic Acid Deficiency; Humans; Lymphoma; Phenytoin; Time

1985
Michaelis-Menten kinetics and the steady-state serum phenytoin/hydroxyphenytoin ratio.
    Therapeutic drug monitoring, 1985, Volume: 7, Issue:4

    Topics: Adolescent; Adult; Child; Epilepsy; Half-Life; Humans; Kinetics; Middle Aged; Phenytoin

1985
Phenytoin/clonazepam interaction.
    Therapeutic drug monitoring, 1985, Volume: 7, Issue:4

    Topics: Adult; Benzodiazepinones; Clonazepam; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans

1985
The role of antiepileptics in sudden death in epilepsy.
    Acta neurologica Scandinavica, 1985, Volume: 72, Issue:4

    Topics: Adult; Anticonvulsants; Carbamazepine; Death, Sudden; Epilepsy; Female; Humans; Male; Patient Compli

1985
Multiple sclerosis in childhood: long term katamnestic investigations.
    Acta paediatrica Hungarica, 1985, Volume: 26, Issue:3

    Topics: Adolescent; Age Factors; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans;

1985
[Methods of individualizing phenytoin dosage].
    Harefuah, 1985, Nov-15, Volume: 109, Issue:10

    Topics: Drug Administration Schedule; Epilepsy; Humans; Methods; Phenytoin

1985
Comparative safety of carbamazepine & phenytoin in the treatment of epilepsy.
    The Indian journal of medical research, 1985, Volume: 82

    Topics: Carbamazepine; Cells, Cultured; Epilepsy; Humans; Lymphocytes; Phenytoin; Sister Chromatid Exchange

1985
[Convulsive crises in childhood].
    Anales espanoles de pediatria, 1985, Volume: 23, Issue:8

    Topics: Clonazepam; Crying; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Infant; Infant, Newborn; Mi

1985
Effects of diphenylhydantoin and cholinergic agents on the neuronally isolated cerebral cortex.
    Electroencephalography and clinical neurophysiology, 1971, Volume: 30, Issue:5

    Topics: Animals; Atropine; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy;

1971
Plasma gamma-glutamyl transpeptidase elevation in patients receiving enzyme-inducing drugs.
    Lancet (London, England), 1971, Aug-14, Volume: 2, Issue:7720

    Topics: Acyltransferases; Depression; Drug Synergism; Enzyme Induction; Epilepsy; Ethanol; Glutamates; Human

1971
Is phenytoin carcinogenic?
    Lancet (London, England), 1971, Nov-13, Volume: 2, Issue:7733

    Topics: Carcinogens; Cell Transformation, Neoplastic; Epilepsy; Humans; Lymphatic Diseases; Lymphoma; Phenyt

1971
Congenital malformations among infants born to epileptic women.
    Lancet (London, England), 1973, Jan-06, Volume: 1, Issue:7793

    Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Congenital Abnormalities; England; Epilepsy; F

1973
4 C-sex vertex spindles.
    Electroencephalography and clinical neurophysiology, 1973, Volume: 34, Issue:5

    Topics: Action Potentials; Brain; Brain Concussion; Cerebrovascular Disorders; Electroencephalography; Epile

1973
Errors in phenytoin dosage.
    Lancet (London, England), 1973, Aug-04, Volume: 2, Issue:7823

    Topics: Ataxia; Child; Child, Preschool; Epilepsy; Female; Headache; Humans; Male; Medication Errors; Phenyt

1973
Letter: Chronic phenytoin therapy and carbohydrate tolerance.
    Lancet (London, England), 1973, Oct-27, Volume: 2, Issue:7835

    Topics: Adolescent; Adult; Child; Epilepsy; Glucose Tolerance Test; Humans; Hyperglycemia; Pancreas; Phenyto

1973
Coarse features in epilepsy as a consequence of anticonvulsant therapy. Report of cases in two pairs of identical twins.
    Lancet (London, England), 1973, Nov-17, Volume: 2, Issue:7838

    Topics: Acromegaly; Adult; Anticonvulsants; Carbamazepine; Child; Diazepam; Diseases in Twins; Epilepsy; Epi

1973
Are anticonvulsants oncogenic?
    Lancet (London, England), 1974, Apr-20, Volume: 1, Issue:7860

    Topics: Anticonvulsants; Denmark; Epilepsy; Female; Humans; Male; Neoplasms; Phenobarbital; Phenytoin; Primi

1974
Letter: Anticonvulsants and congenital abnormalities.
    Lancet (London, England), 1974, Jul-06, Volume: 2, Issue:7871

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Female; Fingers; He

1974
Comparison of spectrophotometric and gas-liquid chromatographic measurements of serum diphenylhydantoin concentrations in epileptic out-patients.
    Journal of neurology, 1974, Jun-27, Volume: 207, Issue:2

    Topics: Adolescent; Adult; Aged; Ambulatory Care; Child; Chromatography, Gas; Epilepsy; Female; Humans; Male

1974
Phenytoin and folate deficiency: failure to show dose dependency.
    Journal of neurology, 1974, Jun-27, Volume: 207, Issue:2

    Topics: Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenytoin; Time Factors

1974
Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin).
    Lancet (London, England), 1971, Dec-04, Volume: 2, Issue:7736

    Topics: Adolescent; Adult; Aged; Antibody Formation; Antigens, Bacterial; Child; Epilepsy; Hodgkin Disease;

1971
[Calcium metabolism during antiepileptic therapy].
    Der Nervenarzt, 1973, Volume: 44, Issue:3

    Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Antipsychotic Agents; Calcium; Calcium Isotopes; Creat

1973
[Frequency of rickets-like bone lesions during anticonvulsive therapy].
    Kinderarztliche Praxis, 1973, Volume: 41, Issue:2

    Topics: Adolescent; Anticonvulsants; Barbiturates; Bone Development; Carpal Bones; Child; Child, Preschool;

1973
[Diphenylhydantoin in children. Clinico-pharmacological studies].
    Deutsche medizinische Wochenschrift (1946), 1973, Jul-20, Volume: 98, Issue:29

    Topics: Adolescent; Alkaline Phosphatase; Ataxia; Body Weight; Calcium; Child; Child, Preschool; Diplopia; D

1973
Clonazepam (Ro 5-4023) in the treatment of myoclonus epilepsy. Four case reports.
    Acta neurologica Scandinavica. Supplementum, 1973, Volume: 53

    Topics: Adult; Anticonvulsants; Benzodiazepinones; Chlorobenzenes; Diazepam; Drug Therapy, Combination; Elec

1973
Proceedings: Inhibition of phenytoin metabolism by sulthiame.
    British journal of pharmacology, 1973, Volume: 49, Issue:1

    Topics: Anticonvulsants; Depression, Chemical; Drug Interactions; Epilepsy; Humans; Phenytoin; Thiazines

1973
Choreo-athetosis and encephalopathy induced by phenytoin.
    British medical journal, 1974, Apr-27, Volume: 2, Issue:5912

    Topics: Adolescent; Adult; Ataxia; Athetosis; Carbamazepine; Chorea; Diplopia; Electroencephalography; Epile

1974
Prevalence and treatment of vitamin D deficiency in children on anticonvulsant drugs.
    Archives of disease in childhood, 1974, Volume: 49, Issue:5

    Topics: Adolescent; Alkaline Phosphatase; Anticonvulsants; Calcium; Cholecalciferol; Diet; Enzyme Induction;

1974
Assessment of plasma glutamyl transpeptidase activity and urinary D-glucaric acid excretion as indices of enzyme induction.
    Clinical science and molecular medicine, 1974, Volume: 47, Issue:3

    Topics: Adipates; Anticonvulsants; Child; Child, Preschool; Enzyme Induction; Epilepsy; Female; gamma-Glutam

1974
Epilepsy.
    The Practitioner, 1974, Volume: 213, Issue:1276 SPEC

    Topics: Adrenocorticotropic Hormone; Carbamazepine; Diazepam; Drug Hypersensitivity; Drug-Related Side Effec

1974
Gastrointestinal function in anticonvulsant megaloblastic anaemia.
    Lancet (London, England), 1966, Jan-22, Volume: 1, Issue:7430

    Topics: Adult; Anemia, Macrocytic; Epilepsy; Female; Folic Acid; Humans; Intestinal Absorption; Phenobarbita

1966
Effects of folic acid on the mental state and fit-frequency of drug-treated epileptic patients.
    Lancet (London, England), 1967, May-20, Volume: 1, Issue:7499

    Topics: Adolescent; Adult; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Humans; M

1967
Neuropsychiatric aspects of anticonvulsant megaloblastic anaemia.
    Lancet (London, England), 1968, Feb-24, Volume: 1, Issue:7539

    Topics: Acetazolamide; Adult; Anemia, Macrocytic; Epilepsy; Female; Folic Acid; Humans; Male; Middle Aged; P

1968
Sources of error in the determination of phenytoin (Dilantin) by Svensmark & Kristensen's method.
    Acta neurologica Scandinavica, 1967, Volume: 43, Issue:4

    Topics: Dicumarol; Epilepsy; Ethosuximide; Humans; Methods; Phenylbutazone; Phenytoin; Spectrophotometry

1967
Longitudinal EEG and clinical study of children with febrile convulsions.
    Electroencephalography and clinical neurophysiology, 1968, Volume: 24, Issue:3

    Topics: Acute Disease; Age Factors; Blood Chemical Analysis; Cerebral Cortex; Child, Preschool; Electroencep

1968
A neuropathological study of a case of petit mal epilepsy.
    Electroencephalography and clinical neurophysiology, 1968, Volume: 24, Issue:3

    Topics: Adolescent; Basal Ganglia; Brain; Cerebellum; Cerebral Cortex; Epilepsy; Epilepsy, Absence; Ethosuxi

1968
Folic acid and anticonvulsants.
    Lancet (London, England), 1969, Jan-25, Volume: 1, Issue:7587

    Topics: Anticonvulsants; Epilepsy; Folic Acid; Humans; Nervous System Diseases; Phenytoin

1969
Acute effects of Dilantin on the EEG of epileptic patients: a quantitative study.
    Electroencephalography and clinical neurophysiology, 1970, Volume: 28, Issue:1

    Topics: Blood-Brain Barrier; Electroencephalography; Epilepsy; Humans; Phenytoin

1970
Neonatal coagulation defect due to anticonvulsant drug treatment in pregnancy.
    Lancet (London, England), 1970, Feb-07, Volume: 1, Issue:7641

    Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Blood Coagulation Disorders; Blood Coagulation Tes

1970
Coagulation defect due to anticonvulsant drug treatment in pregnancy.
    Lancet (London, England), 1970, Feb-21, Volume: 1, Issue:7643

    Topics: Adult; Blood Coagulation Disorders; Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, Dise

1970
Neonatal haemorrhage following maternal anticonvulsant therapy.
    Lancet (London, England), 1970, Mar-07, Volume: 1, Issue:7645

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Male; Phenobarbital; Phenytoin; P

1970
A case of reading epilepsy with observations on the effect of sleep deprivation and fasting on eeg correlates.
    Electroencephalography and clinical neurophysiology, 1970, Volume: 28, Issue:5

    Topics: Adult; Electroencephalography; Epilepsy; Fasting; Humans; Male; Phenytoin; Reading; Sleep Deprivatio

1970
Effect of anticonvulsant drugs on insecticide residues.
    Lancet (London, England), 1970, Sep-05, Volume: 2, Issue:7671

    Topics: Agriculture; Epilepsy; Humans; Insecticides; Phenobarbital; Phenytoin

1970
Abnormal pharmacokinetics of phenytoin in a patient with uraemia.
    Lancet (London, England), 1970, Oct-17, Volume: 2, Issue:7677

    Topics: Epilepsy; Humans; Male; Middle Aged; Phenytoin; Uremia

1970
The effect of anticonvulsant therapy upon the absorption of folates.
    Clinical science, 1973, Volume: 44, Issue:6

    Topics: Adult; Aged; Anticonvulsants; Biological Assay; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans;

1973
[Inheritance of spike-wave complexes and febrile seizures in three generations].
    Deutsche medizinische Wochenschrift (1946), 1973, Sep-14, Volume: 98, Issue:37

    Topics: Adult; Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; Ethosuximi

1973
Antiepileptic therapy and rickets in children.
    Radiology, 1973, Volume: 109, Issue:2

    Topics: Adolescent; Anticonvulsants; Barbiturates; Child; Child, Preschool; Diazepam; Epilepsy; Epilepsy, To

1973
[Phenytoin-induced folic acid deficiency].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1973, Jun-30, Volume: 93, Issue:18

    Topics: Adult; Aged; Anemia, Macrocytic; Epilepsy; Epilepsy, Post-Traumatic; Female; Folic Acid; Folic Acid

1973
The pattern of epilepsy in Uganda.
    Tropical and geographical medicine, 1973, Volume: 25, Issue:3

    Topics: Adolescent; Adult; Age Factors; Black People; Child; Child, Preschool; Electroencephalography; Epile

1973
Folate studies in underprivileged children with epilepsy.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, Nov-24, Volume: 47, Issue:46

    Topics: Anticonvulsants; Biological Assay; Child; Child, Preschool; Epilepsy; Euglena; Folic Acid; Hematocri

1973
Binding of folic acid to serum proteins. II. The effect of diphenylhydantoin treatment and of various diseases.
    Acta haematologica, 1973, Volume: 50, Issue:5

    Topics: Adolescent; Adult; Aged; Blood Proteins; Chromatography, Ion Exchange; Dextrans; Epilepsy; Fatty Aci

1973
[Worsening of epilepsies under treatment].
    Arquivos de neuro-psiquiatria, 1973, Volume: 31, Issue:4

    Topics: Anticonvulsants; Benzodiazepinones; Child; Child, Preschool; Chlorobenzenes; Drug Therapy, Combinati

1973
Epilepsy in cerebral hydatidosis.
    Epilepsia, 1974, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Brain Diseases; Child; Child, Preschool; Dominance, Cerebral; Echinococcosis; Ele

1974
[A case of phenytoin intoxication].
    Lakartidningen, 1974, Mar-06, Volume: 71, Issue:10

    Topics: Adult; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Male; Phenytoin

1974
[Enhanced drug hydroxylation in man under diphenyl-hydantoin therapy].
    Arzneimittel-Forschung, 1974, Volume: 24, Issue:7

    Topics: Administration, Oral; Antipyrine; Biodegradation, Environmental; Creatinine; Epilepsy; Epilepsy, Ton

1974
Folic acid and dilantin antagonism in pregnancy.
    Obstetrics and gynecology, 1974, Volume: 44, Issue:3

    Topics: Adult; Chromatography, Gas; Drug Antagonism; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Fe

1974
Inhibition of intestinal absorption of folic acid by phenytoin.
    Acta haematologica, 1974, Volume: 52, Issue:1

    Topics: Adult; Aged; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Hydrogen-Ion Concentration

1974
Occipital lobe epilepsy. A clinical and electroencephalographic study.
    European neurology, 1974, Volume: 11, Issue:6

    Topics: Adolescent; Adult; Blindness; Child; Diagnosis, Differential; Electroencephalography; Epilepsy; Epil

1974
Anticonvulsant effect of diphenylhydantoin relative to plasma levels. A prospective three-year study in ambulant patients with generalized epileptic seizures.
    Archives of neurology, 1974, Volume: 31, Issue:5

    Topics: Adolescent; Adult; Aged; Ambulatory Care; Ataxia; Chromatography, Gas; Epilepsy; Epilepsy, Tonic-Clo

1974
Clonazepam in the treatment of epilepsy.
    The Medical journal of Australia, 1974, Jul-06, Volume: 2, Issue:1

    Topics: Adult; Anticonvulsants; Benzodiazepinones; Chlorobenzenes; Chromatography, Gas; Drug Interactions; E

1974
Therapy of seizures in children.
    American family physician, 1974, Volume: 10, Issue:3

    Topics: Child; Diazepam; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Injections, Intramuscular; Injec

1974
[Polyneuropathy due to diphenylhydantoin overdosage].
    Der Nervenarzt, 1974, Volume: 45, Issue:8

    Topics: Adult; Epilepsy; Humans; Long-Term Care; Male; Paralysis; Phenytoin; Polyneuropathies

1974
Prolonged trance-like stupor in epilepsy. Petit mal status-wave stupor, spaced-out status.
    Archives of internal medicine, 1974, Volume: 134, Issue:6

    Topics: Adult; Behavior; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Abse

1974
[Letter: Ovulation inhibitors during anticonvulsive therapy?].
    Deutsche medizinische Wochenschrift (1946), 1974, Dec-20, Volume: 99, Issue:51

    Topics: Adult; Anticonvulsants; Contraceptives, Oral; Drug Interactions; Epilepsy; Female; Humans; Long-Term

1974
[Myopathy and osteomalacia after longterm antiepileptic treatment (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1974, Nov-29, Volume: 116, Issue:48

    Topics: Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Calcium; Calcium Metabolism Disorders; Chi

1974
The dysmorphogenic potential of phenytoin: experimental observations.
    Drugs, 1974, Volume: 8, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Epilepsy; Female; Fetus; Folic Acid; Folic Acid Deficiency; Ha

1974
Epilepsy in the elderly.
    Age and ageing, 1974, Volume: 3, Issue:4

    Topics: Age Factors; Aged; Angiography; Brain Neoplasms; Cerebrovascular Disorders; Dementia; Electroencepha

1974
Side effects of clonazepam therapy.
    Proceedings of the Australian Association of Neurologists, 1974, Volume: 11

    Topics: Adolescent; Adult; Aggression; Ataxia; Benzodiazepinones; Clonazepam; Drug Interactions; Epilepsy; E

1974
[Phenytoin (5,5-diphenylhydantoin) hypersensitivity presenting a clinical picture of scarlatiniform erythroderma].
    Das Deutsche Gesundheitswesen, 1966, Jul-07, Volume: 21, Issue:27

    Topics: Child; Dermatitis, Exfoliative; Drug Hypersensitivity; Epilepsy; Female; Hematopoietic System; Human

1966
The oxytalan connective tissue fibres in gingival hyperplasia in patients treated with sodium diphenylhydantoin.
    Journal of periodontal research, 1967, Volume: 2, Issue:2

    Topics: Connective Tissue; Epilepsy; Gingival Hyperplasia; Phenytoin

1967
Diphenylhydantoin intoxication and cerebrospinal fluid protein.
    Neurology, 1968, Volume: 18, Issue:10

    Topics: Adenosine Triphosphatases; Adult; Cerebellar Ataxia; Cerebrospinal Fluid Proteins; Epilepsy; Female;

1968
The effect of 5,5-diphenylhydantoin (dilantin) on fibroblast-like cells in culture.
    Journal of periodontal research, 1969, Volume: 4, Issue:2

    Topics: Epilepsy; Fibroblasts; Gingival Hyperplasia; Phenytoin

1969
Diphenylhydantoin therapy.
    Archives of dermatology, 1970, Volume: 102, Issue:5

    Topics: Adolescent; Drug Eruptions; Epilepsy; Erythema Multiforme; Humans; Phenytoin

1970
Current concepts--status epilepticus.
    The Nebraska state medical journal, 1970, Volume: 55, Issue:11

    Topics: Aldehydes; Anesthetics; Anticonvulsants; Barbiturates; Bromides; Epilepsy; Humans; Phenytoin; Tranqu

1970
[Outpatient therapy of epilepsy].
    Zeitschrift fur arztliche Fortbildung, 1970, Jul-15, Volume: 64, Issue:14

    Topics: Anticonvulsants; Barbiturates; Depression, Chemical; Drug Eruptions; Drug Hypersensitivity; Epilepsi

1970
Brain synapses. An in vitro model for the study of seizures.
    Archives of internal medicine, 1972, Volume: 129, Issue:2

    Topics: Adenosine Triphosphatases; Animals; Biological Transport; Brain; Disease Models, Animal; Electroence

1972
Radiologic bone changes and hypocalcemia with anticonvulsant therapy in epilepsy.
    Annals of internal medicine, 1972, Volume: 77, Issue:3

    Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Back Pain; Calcium; Carbamazepine; D

1972
Severe cutaneous reactions to phenytoin.
    Archives of disease in childhood, 1973, Volume: 48, Issue:3

    Topics: Child; Drug Eruptions; Epilepsy; Female; Humans; Male; Phenytoin

1973
Paroxysmal choreoathetosis. Report of Chinese cases.
    Neurology, 1973, Volume: 23, Issue:7

    Topics: Adult; Age Factors; Athetosis; China; Electroencephalography; Epilepsy; Female; Humans; Huntington D

1973
Carbamazepine as an anticonvulsant: a pilot study.
    Neurology, 1974, Volume: 24, Issue:9

    Topics: Administration, Oral; Adult; Anticonvulsants; Carbamazepine; Drug Eruptions; Epilepsy; Eye Movements

1974
Peripheral neuropathy in long-term diphenylhydantoin therapy.
    Archives of neurology, 1968, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Child; Electromyography; Electrophysiology; Epilepsy; Humans; Middle Aged; Muscle

1968
Inhibitory effect of diphenylhydantoin on the feedback control of corticotrophin release.
    Acta endocrinologica, 1969, Volume: 61, Issue:3

    Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult;

1969
The effect of tegretol on some elementary neuronal mechanisms.
    Headache, 1969, Volume: 9, Issue:1

    Topics: Animals; Carbamazepine; Cats; Dibenzazepines; Epilepsy; Phenytoin; Synapses; Synaptic Transmission;

1969
Effect of diphenylhydantoin on the metabolism of metyrapone and release of ACTH in man.
    The Journal of clinical endocrinology and metabolism, 1969, Volume: 29, Issue:12

    Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Depression, Chemical; Epilepsy; Humans; Hydr

1969
[American neurology for Swedish use].
    Lakartidningen, 1968, Apr-10, Volume: 65, Issue:15

    Topics: Adrenocorticotropic Hormone; Ampicillin; Brain Diseases; Cerebrovascular Disorders; Contrast Media;

1968
Peripheral neuropathy in long-term diphenylhydantoin therapy.
    Transactions of the American Neurological Association, 1967, Volume: 92

    Topics: Adult; Aged; Epilepsy; Female; Humans; Male; Middle Aged; Neuritis; Neurologic Examination; Peripher

1967
Dilantin and metyrapone: a clinically significant example of enzyme induction.
    Transactions of the American Clinical and Climatological Association, 1970, Volume: 81

    Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Animals; Depression, Chemical; Endoplasmic R

1970
Drug treatment of convulsive disorders.
    The New England journal of medicine, 1972, Mar-02, Volume: 286, Issue:9

    Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; E

1972
Progressive myoclonus with epilepsy.
    Southern medical journal, 1972, Volume: 65, Issue:1

    Topics: Adult; Child; Chlordiazepoxide; Epilepsy; Female; Humans; Inclusion Bodies; Lipidoses; Myoclonic Cer

1972
Diphenylhydantoin-induced cerebellar degeneration.
    Archives of neurology, 1972, Volume: 27, Issue:5

    Topics: Adolescent; Cerebellar Ataxia; Cerebellar Diseases; Child; Electroencephalography; Epilepsy; Female;

1972
[Hydantoins and neurologic complications].
    La Nouvelle presse medicale, 1973, Feb-24, Volume: 2, Issue:8

    Topics: Adolescent; Brain Diseases; Cerebrospinal Fluid Proteins; Drug Hypersensitivity; Epilepsy; Humans; H

1973
[Epilepsy and perinatal injury].
    Revue medicale de la Suisse romande, 1973, Volume: 93, Issue:1

    Topics: Adolescent; Adrenocorticotropic Hormone; Barbiturates; Birth Injuries; Brain Diseases; Cerebral Hemo

1973
Peripheral nerve function in long-term therapy with diphenylhydantoin. A clinical and electrophysiologic correlation.
    Neurology, 1974, Volume: 24, Issue:5

    Topics: Adult; Aged; Carbamazepine; Electric Stimulation; Electromyography; Epilepsy; Ethosuximide; Evoked P

1974
Nerve conduction velocity in patients on long-term diphenylhydantoin therapy.
    Epilepsia, 1974, Volume: 15, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aged; Child; Drug Therapy, Combination; Electrodiagnosis; Epilepsy;

1974
Iatrogenic disorders in epilepsy.
    Modern trends in neurology, 1970, Volume: 5, Issue:0

    Topics: Adrenal Insufficiency; Anemia, Macrocytic; Animals; Anticonvulsants; Cats; Cerebellar Diseases; Drug

1970
[Anticonvulsants and vitamin D metabolism (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1974, Sep-13, Volume: 116, Issue:37

    Topics: Animals; Anticonvulsants; Avitaminosis; Body Weight; Calcium; Calcium Radioisotopes; Cholecalciferol

1974
Neonatal effects of maternal treatment with the anticonvulsant drug diphenylhydantoin.
    Obstetrics and gynecology, 1971, Volume: 37, Issue:6

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Blood Coagulation Disorders; Epilepsy; Female; Human

1971
Drugs in management of hyperkinetic and perceptually handicapped children.
    JAMA, 1968, Nov-11, Volume: 206, Issue:7

    Topics: Anticonvulsants; Central Nervous System Stimulants; Child; Child, Preschool; Chlordiazepoxide; Chlor

1968
Sulthiame (Ospolot) as inhibitor of diphenylhydatoin metabolism.
    Epilepsia, 1968, Volume: 9, Issue:1

    Topics: Anticonvulsants; Carbon Isotopes; Chromatography, Thin Layer; Epilepsy; Humans; Phenytoin; Radionucl

1968
"Dilatin" overdosage.
    The Medical journal of Australia, 1968, Oct-12, Volume: 2, Issue:15

    Topics: Anticonvulsants; Ataxia; Brain Neoplasms; Carbamazepine; Diagnosis, Differential; Dibenzazepines; Ep

1968
Epilepsy.
    British medical journal, 1969, Nov-01, Volume: 4, Issue:5678

    Topics: Adult; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, T

1969
Drug treatment of epilepsy in childhood.
    British medical journal, 1969, Nov-22, Volume: 4, Issue:5681

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diazepam; Epilepsy; Epilepsy, Absence; Epil

1969
[Treatment of partial epilepsies with a sultiamum containing combination].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:12

    Topics: Adolescent; Adult; Aggression; Anticonvulsants; Barbiturates; Caffeine; Child; Electroencephalograph

1969
Diphenylhydantoin.
    The Medical letter on drugs and therapeutics, 1971, Jun-11, Volume: 13, Issue:12

    Topics: Affective Symptoms; Arrhythmias, Cardiac; Ataxia; Carbamazepine; Central Nervous System Diseases; Ch

1971
Anticonvulsant drugs in idiopathic epilepsy.
    The Medical letter on drugs and therapeutics, 1970, Jun-26, Volume: 12, Issue:13

    Topics: Acetazolamide; Anticonvulsants; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Hydantoins; Mepho

1970
A comprehensive scheme for the evaluation of anticonvulsant concentrations in blood using thin-layer chromatography.
    Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 35, Issue:1

    Topics: Acetazolamide; Anticonvulsants; Benzazepines; Carbamazepine; Chlordiazepoxide; Chromatography, Thin

1971
[Medical treatment of epilepsy].
    Harefuah, 1971, Apr-01, Volume: 80, Issue:7

    Topics: Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Hydantoins;

1971
Utilization of a microprogrammable computer for statistical analyses of data from a large epileptic patient population. I. Techniques and preliminary results.
    Epilepsia, 1972, Volume: 13, Issue:4

    Topics: Adolescent; Adult; Computers; Data Display; Epilepsy; Factor Analysis, Statistical; Humans; Informat

1972
Serum -glytamyl transpeptidase activity in liver disease.
    Gut, 1972, Volume: 13, Issue:9

    Topics: Acyltransferases; Adolescent; Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Barbit

1972
Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects.
    Drugs, 1972, Volume: 4, Issue:3

    Topics: Acetates; Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Dibenzazepines; Electroencephalog

1972
Diphenylhydantoin-induced asterixis. A clinical study.
    JAMA, 1974, Jul-29, Volume: 229, Issue:5

    Topics: Ataxia; Electroencephalography; Electromyography; Epilepsy; Female; Humans; Male; Middle Aged; Nysta

1974
A method for shifting from oral to intramuscular diphenylhydantoin administration.
    Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:3

    Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Injections,

1974
Letter: Sleep epilepsy.
    British medical journal, 1974, Oct-12, Volume: 4, Issue:5936

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Delayed-Action Preparations; Dextroamphetam

1974
Status epilepticus.
    American family physician, 1974, Volume: 10, Issue:4

    Topics: Diazepam; Epilepsy; Humans; Hypocalcemia; Hypoglycemia; Magnesium Deficiency; Paraldehyde; Phenobarb

1974
Letter: Anticonvulsants and vitamin D metabolism.
    Developmental medicine and child neurology, 1974, Volume: 16, Issue:5

    Topics: Child; Drug Therapy, Combination; Epilepsy; Humans; Osteomalacia; Phenobarbital; Phenytoin; Primidon

1974
[Antiepileptic drugs and congenital malformations. Interaction between antiepileptic drugs and contraceptives?].
    Ugeskrift for laeger, 1974, Nov-04, Volume: 136, Issue:45

    Topics: Abnormalities, Drug-Induced; Contraceptives, Oral; Drug Interactions; Epilepsy; Female; Humans; Infa

1974
Emergency testing and routine monitoring of therapeutic drugs in a comprehensive analytical system.
    Clinical toxicology, 1974, Volume: 7, Issue:4

    Topics: Adolescent; Amobarbital; Chromatography, Gas; Chromatography, Thin Layer; Electroencephalography; Ep

1974
Serum immunoglobulins in epilepsy.
    Journal of the neurological sciences, 1974, Volume: 23, Issue:3

    Topics: Adult; Drug Therapy, Combination; Epilepsy; Erythrocytes; Female; Folic Acid; Humans; Immunoglobulin

1974
Do anticonvulsants have a teratogenic effect?
    Archives of neurology, 1974, Volume: 31, Issue:6

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Cleft Palate; Congenital

1974
[Plasma diphenylhydantoin concentration in epileptic patients].
    Harefuah, 1974, Sep-15, Volume: 87, Issue:6

    Topics: Drug Interactions; Epilepsy; Humans; Phenobarbital; Phenytoin

1974
[Diphenylhydantoin poisoning due to diphenylhydantoin-isoniazid interaction].
    Schweizerische medizinische Wochenschrift, 1974, Aug-31, Volume: 104, Issue:35

    Topics: Adult; Cognition Disorders; Drug Interactions; Epilepsy; Fatigue; Humans; Isoniazid; Male; Middle Ag

1974
Drug estimation in the treatment of epilepsy.
    Proceedings of the Royal Society of Medicine, 1974, Volume: 67, Issue:12 Pt 1

    Topics: Adult; Biological Availability; Dose-Response Relationship, Drug; Epilepsy; Humans; Kinetics; Male;

1974
[Scleroderma developing during treatment of ictal stupor with diphenylhydantoin].
    Ryumachi. [Rheumatism], 1974, Volume: 14, Issue:3

    Topics: Adult; Epilepsy; Female; Humans; Phenytoin; Scleroderma, Localized

1974
[Considerations and research on febrile convulsions].
    Minerva pediatrica, 1974, Apr-14, Volume: 26, Issue:13

    Topics: Anticonvulsants; Brain Diseases; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencepha

1974
[Special viewpoints in the treatment with anticonvulsants in childhood. Value of determination of serum level of anticonvulsants in the treatment of seizures].
    Fortschritte der Medizin, 1974, Oct-10, Volume: 92, Issue:28

    Topics: Adolescent; Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Male; Phenobarbital; Phenyt

1974
Iatrogenic nutritional effects of anticonvulsants.
    The Proceedings of the Nutrition Society, 1974, Volume: 33, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Blood Coagulation Disorders; Bone Diseases; Child; Child, Presch

1974
Enhancement of diphenylhydantoin-induced anticonvulsant activity of a shaking stress.
    Archives internationales de pharmacodynamie et de therapie, 1974, Volume: 211, Issue:2

    Topics: Animals; Anticonvulsants; Drug Interactions; Electroshock; Epilepsy; Female; Male; Mice; Phenoxybenz

1974
Letter: Effect of phenytoin on serum phenobarbitone levels.
    The British journal of psychiatry : the journal of mental science, 1974, Volume: 125

    Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Huma

1974
Chuckling and glugging seizures at night -- sylvian spike epilepsy.
    Proceedings of the Australian Association of Neurologists, 1974, Volume: 11

    Topics: Child; Clonazepam; Electroencephalography; Epilepsy; Humans; Laughter; Male; Migraine Disorders; Phe

1974
Sympodia.
    American journal of diseases of children (1960), 1974, Volume: 128, Issue:3

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abnormalities, Severe Teratoid; Autopsy; Epile

1974
Effects of age, sex, obesity, and pregnancy on plasma diphenylhydantoin levels.
    Epilepsia, 1974, Volume: 15, Issue:4

    Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Chromatography, Gas; Dose-Response Relationshi

1974
Urinary excretion of diphenylhydantoin metabolites in newborn infants.
    The Journal of pediatrics, 1974, Volume: 85, Issue:4

    Topics: Chromatography, Gas; Epilepsy; Female; Half-Life; Humans; Infant, Newborn; Maternal-Fetal Exchange;

1974
Diphenylhydantoin toxicity: dose-dependent blood dyscrasia.
    Neurology, 1974, Volume: 24, Issue:12

    Topics: Adult; Amenorrhea; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Hypothermia; Hypothyr

1974
Letter: Diphenylhydantoin and blood dyscrasias.
    JAMA, 1974, Oct-14, Volume: 230, Issue:2

    Topics: Epilepsy; Hematologic Diseases; Humans; Phenytoin

1974
Augmentation of cerebellar Purkinje cell discharge rate after diphenylhydantoin.
    Epilepsia, 1972, Volume: 13, Issue:3

    Topics: Acetazolamide; Action Potentials; Cerebellum; Electroencephalography; Epilepsy; Phenobarbital; Pheny

1972
Effects of diphenylhydantoin and other antiepileptic drugs on epileptiform activity and Purkinje cell discharge rates.
    Epilepsia, 1972, Volume: 13, Issue:3

    Topics: Acetazolamide; Action Potentials; Animals; Anticonvulsants; Blood Pressure; Cats; Cerebellum; Electr

1972
Inadvertent chronic diphenylhydantoin intoxication in a teenage girl.
    Journal of the South Carolina Medical Association (1975), 1972, Volume: 68, Issue:9

    Topics: Adolescent; Epilepsy; Female; Humans; Medication Errors; Phenytoin; Self Medication

1972
Incidence of diphenylhydantoin gingival hyperplasia.
    Oral surgery, oral medicine, and oral pathology, 1972, Volume: 34, Issue:6

    Topics: Adolescent; Adult; Aged; Epilepsy; Gingival Hyperplasia; Humans; Middle Aged; Oral Hygiene; Phenytoi

1972
Influence of diphenylhydantoin and phenobarbital on intestinal calcium transport in the rat.
    Epilepsia, 1972, Volume: 13, Issue:6

    Topics: Animals; Binding, Competitive; Calcium; Calcium Isotopes; Calcium Metabolism Disorders; Epilepsy; In

1972
[Epileptic children as patients in a systematic school dental service].
    Tandlaegebladet, 1973, Volume: 77, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Dental Plaque; Epilepsy; Female; Gingiva; Gingival Hyperplasia;

1973
Chronic hydantoin intoxication: case report.
    The New Zealand medical journal, 1972, Volume: 76, Issue:487

    Topics: Adult; Cerebellar Ataxia; Cognition Disorders; Epilepsy; Female; Humans; Nystagmus, Pathologic; Phen

1972
Anticonvulsants and pregnancy.
    The New Zealand medical journal, 1973, Volume: 77, Issue:489

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregna

1973
One daily dose of diphenylhydantoin (DPH) to patients with epilepsy.
    Acta neurologica Scandinavica. Supplementum, 1972, Volume: 51

    Topics: Administration, Oral; Epilepsy; Half-Life; Humans; Phenytoin; Time Factors

1972
The effects of some anticonvulsant drugs on cobalt-induced epilepsy.
    Epilepsia, 1973, Volume: 14, Issue:2

    Topics: Animals; Cobalt; Electroencephalography; Epilepsy; Ethosuximide; Evaluation Studies as Topic; Fronta

1973
Experiences with Bivotril in treatment of epilepsy--particularly minor motor epilepsy--in mentally retarded children.
    Acta neurologica Scandinavica. Supplementum, 1973, Volume: 53

    Topics: Acetazolamide; Adolescent; Adult; Anticonvulsants; Benzodiazepinones; Child; Child, Preschool; Chlor

1973
A clinical trial with clonazepam (Ro 5-4023).
    Acta neurologica Scandinavica. Supplementum, 1973, Volume: 53

    Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Benzodiazepinones; Carbamazepine; Child; Chloroben

1973
[Hydantoin-induced hyperplasia].
    Deutsche zahnarztliche Zeitschrift, 1973, Volume: 28, Issue:12

    Topics: Adolescent; Adult; Child; Dental Plaque; Epilepsy; Female; Gingival Hyperplasia; Gingivectomy; Human

1973
Post-rotational nystagmus. An unreliable sign of diphenylhydantoin toxicity.
    Epilepsia, 1973, Volume: 14, Issue:4

    Topics: Chromatography, Thin Layer; Epilepsy; Humans; Nystagmus, Pathologic; Phenytoin; Rotation

1973
Editorial: Management of status epilepticus.
    The New Zealand medical journal, 1974, Feb-27, Volume: 79, Issue:509

    Topics: Barbiturates; Diazepam; Epilepsy; Humans; Paraldehyde; Phenytoin

1974
Anticonvulsant drug-serum levels in psychiatric patients with seizure disorders. Effects of certain psychotropic drugs.
    New York state journal of medicine, 1974, Volume: 74, Issue:9

    Topics: Chlorpromazine; Chromatography, Gas; Diazepam; Drug Interactions; Epilepsy; Humans; Mental Disorders

1974
[Acute leukemia induced by diphenylhydantoin? Apropos of 4 cases].
    Revue neurologique, 1973, Volume: 129, Issue:5

    Topics: Adult; Bone Marrow; Drug Therapy, Combination; Epilepsy; Female; Humans; Leukemia, Lymphoid; Lung; L

1973
One daily dose of diphenylhydantoin for patients with epilepsy.
    Epilepsia, 1974, Volume: 15, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Tim

1974
Root abnormalities in epileptics and the inhibition of parathyroid hormone induced bone resorption by diphenyl hydantoin in tissue culture.
    Archives of oral biology, 1974, Volume: 19, Issue:11

    Topics: Adult; Animals; Bone Resorption; Culture Techniques; Epilepsy; Humans; Mice; Parathyroid Hormone; Pe

1974
Editorial: Plasma diphenylhydantoin levels.
    Australian and New Zealand journal of medicine, 1974, Volume: 4, Issue:5

    Topics: Adult; Age Factors; Child; Drug Interactions; Epilepsy; Female; Humans; Liver; Male; Mixed Function

1974
[Epileptic children as patients in a systematic school dental service].
    Tandlaegebladet, 1973, Volume: 77, Issue:1

    Topics: Adolescent; Child; Denmark; Epilepsy; Gingival Hyperplasia; Humans; Phenytoin; School Dentistry

1973
Initial and maintenance dose of vitamin D2 in the treatment of anticonvulsant osteomalacia.
    Acta neurologica Scandinavica, 1974, Volume: 50, Issue:5

    Topics: Adult; Alkaline Phosphatase; Bone and Bones; Calcium; Epilepsy; Ergocalciferols; Female; Humans; Mal

1974
[An autopsy case of epilepsy complicated with dilantin gingival hyperplasia (author's transl)].
    Nihon Shishubyo Gakkai kaishi, 1974, Volume: 16, Issue:1

    Topics: Adult; Autopsy; Epilepsy; Gingival Hyperplasia; Humans; Male; Phenytoin

1974
Effective treatment of Dilantin gingival hyperplasia.
    Oral surgery, oral medicine, and oral pathology, 1973, Volume: 35, Issue:1

    Topics: Adolescent; Adult; Dentures; Epilepsy; Female; Gingival Hyperplasia; Gingivectomy; Humans; Male; Phe

1973
Penicillin-induced epileptogenic foci. I. Time course and the anticonvulsant effects of diphenylhydantoin and diazepam.
    Neuropharmacology, 1974, Volume: 13, Issue:4

    Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Cerebral Ventricles; Diazepam; Dose-Response Relati

1974
[Dental treatment for patients with epileptic seizures].
    Schweizerische Monatsschrift fur Zahnheilkunde = Revue mensuelle suisse d'odonto-stomatologie, 1974, Volume: 84, Issue:9

    Topics: Adolescent; Dental Care; Denture Repair; Dentures; Epilepsy; Female; Gingival Hyperplasia; Humans; M

1974
Diazepam as an oral long-term anticonvulsant for epileptic mental patients.
    Diseases of the nervous system, 1972, Volume: 33, Issue:2

    Topics: Amobarbital; Anticonvulsants; Diazepam; Epilepsy; Evaluation Studies as Topic; Female; Humans; Long-

1972
A medical and social survey of 231 children with seizures.
    Epilepsia, 1972, Volume: 13, Issue:1

    Topics: Adolescent; Attitude to Health; Child; Child Behavior Disorders; Child, Preschool; Electroencephalog

1972
The density and ultrastructure of the Purkinje cells following diphenylhydantoin treatment in animals and man.
    Acta neurologica Scandinavica. Supplementum, 1972, Volume: 49

    Topics: Animals; Autopsy; Cell Count; Cerebellum; Epilepsy; Epilepsy, Tonic-Clonic; Female; Haplorhini; Huma

1972
The action of some anticonvulsant drugs on cobalt-induced epilepsy and on the bemegride threshold in alert cats.
    Epilepsia, 1972, Volume: 13, Issue:3

    Topics: Animals; Anticonvulsants; Bemegride; Carbamazepine; Cats; Cobalt; Diazepam; Electroencephalography;

1972
Sensory and motor nerve conduction velocity in long-term diphenylhydantoin therapy.
    Arquivos de neuro-psiquiatria, 1972, Volume: 30, Issue:3

    Topics: Adolescent; Adult; Epilepsy; Female; Humans; Long-Term Care; Male; Median Nerve; Middle Aged; Motor

1972
Suppressant effects of diphenylhydantoin on the cortical epileptogenic focus.
    Neurology, 1973, Volume: 23, Issue:3

    Topics: Animals; Cats; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Electroencephalography

1973
[A new case of the so-called "hydantoin perniciosa"].
    Die Medizinische Welt, 1972, Sep-23, Volume: 23, Issue:39

    Topics: Anemia, Pernicious; Epilepsy; Female; Humans; Middle Aged; Phenytoin

1972
Potential hazards of hydantoin use.
    Annals of internal medicine, 1972, Volume: 77, Issue:6

    Topics: Epilepsy; Female; Humans; Immunity, Cellular; Immunoglobulins; Immunologic Deficiency Syndromes; Phe

1972
Effect of dosage increments on blood phenytoin concentrations.
    Journal of neurology, neurosurgery, and psychiatry, 1972, Volume: 35, Issue:6

    Topics: Administration, Oral; Dose-Response Relationship, Drug; Epilepsy; Humans; Phenytoin

1972
[Apnea and heart arrest following distraneurin therapy. Clinical, neurophysiological and neuropathological aspects].
    Der Nervenarzt, 1972, Volume: 43, Issue:12

    Topics: Adult; Apnea; Basal Ganglia; Cerebral Cortex; Chlormethiazole; Drug Synergism; Electroencephalograph

1972
[Hydantoins today].
    La Revue du praticien, 1972, Dec-21, Volume: 22, Issue:33

    Topics: Arrhythmias, Cardiac; Carbohydrate Metabolism; Central Nervous System; Diabetic Neuropathies; Epilep

1972
Effectiveness of single daily doses of diphenylhydantoin.
    Neurology, 1972, Volume: 22, Issue:10

    Topics: Epilepsy; Evaluation Studies as Topic; Humans; Motor Skills; Neurologic Examination; Phenytoin; Refl

1972
Tonic seizures induced by movement.
    Neurology, 1972, Volume: 22, Issue:6

    Topics: Adolescent; Electroencephalography; Epilepsy; Humans; Male; Movement; Neurologic Examination; Phenyt

1972
Relationships between serum and cerebrospinal fluid anticonvulsant drug and folic acid concentrations in epileptic patients.
    Neurology, 1972, Volume: 22, Issue:8

    Topics: Adult; Chromatography, Gas; Epilepsy; Female; Folic Acid; Humans; Male; Phenobarbital; Phenytoin; Pr

1972
Toxic encephalopathy with seizures secondary to ingestion of composition C-4. A clinical and electroencephalographic study.
    Neurology, 1972, Volume: 22, Issue:8

    Topics: Adult; Brain Diseases; Electroencephalography; Epilepsy; Explosions; Humans; Male; Military Medicine

1972
The simultaneous determination of multiple anticonvulsant drug levels by gas-liquid chromatography. Method and clinical application.
    Neurology, 1972, Volume: 22, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Chromatography, Gas; Epilepsy; Ethosuxi

1972
[Diurnal rhythm of plasma cortisol in epileptic patients].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1972, Volume: 74, Issue:7

    Topics: Adult; Age Factors; Circadian Rhythm; Epilepsy; Female; Humans; Hydrocortisone; Male; Middle Aged; P

1972
[Nutritional and experimental studies on folic acid deficiency due to anticonvulsants].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1972, Volume: 61, Issue:7

    Topics: Adult; Anemia, Macrocytic; Animals; Anticonvulsants; Diet; Epilepsy; Folic Acid; Folic Acid Deficien

1972
[Differences between individuals in human pharmacokinetics. Clinical significance].
    Munchener medizinische Wochenschrift (1950), 1972, Sep-22, Volume: 114, Issue:38

    Topics: Binding Sites; Desipramine; Epilepsy; Female; Humans; Male; Nortriptyline; Pharmacogenetics; Phenyto

1972
Clinical and physiological effects of stimulation of the paleocerebellum in humans.
    Journal of the American Geriatrics Society, 1973, Volume: 21, Issue:1

    Topics: Adult; Cerebellum; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy; Ep

1973
Use of diphenylhydantoin.
    Annals of internal medicine, 1973, Volume: 78, Issue:2

    Topics: Epilepsy; Humans; Injections, Intravenous; Phenytoin

1973
Use of diphenylhydantoin.
    Annals of internal medicine, 1973, Volume: 78, Issue:2

    Topics: Epilepsy; Humans; Injections, Intravenous; Nystagmus, Pathologic; Phenytoin

1973
Follow-up of epileptic outpatients.
    Southern medical journal, 1973, Volume: 66, Issue:3

    Topics: Adolescent; Adult; Aged; Educational Status; Employment; Epilepsy; Female; Follow-Up Studies; Humans

1973
[Epilepsy and pregnancy].
    Geburtshilfe und Frauenheilkunde, 1973, Volume: 33, Issue:3

    Topics: Abortion, Spontaneous; Anticonvulsants; Birth Weight; Epilepsy; Female; Humans; Infant, Newborn; Inf

1973
Leucine aminopeptidase isoenzyme changes after treatment with anticonvulsant drugs.
    Clinica chimica acta; international journal of clinical chemistry, 1973, Mar-30, Volume: 44, Issue:3

    Topics: Blood Protein Electrophoresis; Blood Proteins; Epilepsy; Humans; Isoenzymes; Jaundice; Leucyl Aminop

1973
[Phenytoin--blood levels and clinical aspects].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1973, Feb-28, Volume: 93, Issue:6

    Topics: Administration, Oral; Drug Interactions; Epilepsy; Humans; Isoniazid; Phenytoin; Protein Binding; Ti

1973
Effects of diphenylhydantoin on activity of rat cerebellar Purkinje cells.
    Neuropharmacology, 1973, Volume: 12, Issue:5

    Topics: Action Potentials; Animals; Behavior, Animal; Blood Pressure; Dose-Response Relationship, Drug; Elec

1973
Epilepsy and pregnancy: a report from the Oxford Record Linkage Study.
    British medical journal, 1973, May-26, Volume: 2, Issue:5864

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Child; Congenital Abnormalities; Drug S

1973
Abdominal epilepsy.
    Annales chirurgiae et gynaecologiae Fenniae, 1973, Volume: 62, Issue:2

    Topics: Abdomen; Carbamazepine; Colic; Diagnosis, Differential; Electroencephalography; Epilepsy; Humans; Ma

1973
Diencephalic autonomic epilepsy caused by a neoplasm.
    The Journal of pediatrics, 1973, Volume: 83, Issue:2

    Topics: Astrocytoma; Autonomic Nervous System; Brain Neoplasms; Diencephalon; Epilepsy; Female; Humans; Infa

1973
Control rate in diphenylhydantoin therapy.
    The Journal of pediatrics, 1973, Volume: 83, Issue:2

    Topics: Epilepsy; Evaluation Studies as Topic; Humans; Phenytoin

1973
[Ambulatory extended care for the child with seizures].
    Zeitschrift fur arztliche Fortbildung, 1973, Apr-01, Volume: 67, Issue:7

    Topics: Adolescent; Age Factors; Ambulatory Care; Child; Child, Preschool; Diazepam; Epilepsy; Ethosuximide;

1973
Serum diphenylhydantoin, triglyceride and cholesterol concentration.
    The New England journal of medicine, 1973, Oct-11, Volume: 289, Issue:15

    Topics: Adult; Cholesterol; Epilepsy; Female; Humans; Hyperlipidemias; Male; Middle Aged; Phenytoin; Triglyc

1973
Effect of diphenylhydantoin therapy on folate metabolism of mentally retarded epileptics.
    The Tohoku journal of experimental medicine, 1973, Volume: 110, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Azo Compounds; Child; Epilepsy; Female; FIGLU Test; Folic Acid;

1973
Pheneturide, a more potent liver enzyme inducer in man than phenobarbitone?
    British journal of pharmacology, 1973, Volume: 47, Issue:3

    Topics: Adipates; Anticonvulsants; Enzyme Induction; Epilepsy; Female; Humans; Liver; Male; Phenobarbital; P

1973
Diphenylhydantoin-induced gingival hyperplasia: its relationship to dose and serum level.
    Developmental medicine and child neurology, 1973, Volume: 15, Issue:4

    Topics: Adolescent; Adult; Age Factors; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Gingival

1973
[Diphenylhydantoin poisoning induced by isoniazide. A further case].
    Archives francaises de pediatrie, 1973, Volume: 30, Issue:5

    Topics: Child; Drug Interactions; Electroencephalography; Epilepsy; Humans; Isoniazid; Male; Neurologic Mani

1973
Primidone, diphenylhydantoin and phenobarbital. Aspects of acute and chronic toxicity.
    Neurology, 1973, Volume: 23, Issue:2

    Topics: Ataxia; Chromatography, Gas; Drug Tolerance; Epilepsy; Humans; Nystagmus, Pathologic; Phenobarbital;

1973
Plasma diphenylhydantoin values after oral and intramuscular administration of diphenylhydantoin.
    Neurology, 1973, Volume: 23, Issue:3

    Topics: Administration, Oral; Dose-Response Relationship, Drug; Epilepsy; Humans; Injections, Intramuscular;

1973
Inadequate serum levels after intramuscular administration of diphenylhydantoin.
    Neurology, 1973, Volume: 23, Issue:3

    Topics: Administration, Oral; Animals; Child; Epilepsy; Evaluation Studies as Topic; Humans; Injections, Int

1973
Epileptic pain. An uncommon manifestation with localizing value.
    Neurology, 1973, Volume: 23, Issue:5

    Topics: Adenocarcinoma; Adult; Brain Neoplasms; Cerebral Angiography; Diazepam; Epilepsy; Female; Humans; Ma

1973
Rickets precipitated by anticonvulsant drugs in a child receiving prophylactic vitamin D.
    American journal of diseases of children (1960), 1973, Volume: 125, Issue:6

    Topics: Adolescent; Alkaline Phosphatase; Calcium; Epilepsy; Female; Humans; Ilium; Phenobarbital; Phenytoin

1973
Preliminary observations of serum carbamazepine concentration in epileptic patients.
    Neurology, 1973, Volume: 23, Issue:4

    Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Humans; Male; Mid

1973
Diphenylhydantoin in children. Pharmacology and efficacy.
    Neurology, 1973, Volume: 23, Issue:9

    Topics: Age Factors; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Evaluation Studies

1973
[Genetic questionnaire. Genetic counseling for a patient with the complex association of G-6-PD deficiency, Gronblad-Strandberg syndrome (pseudo-xanthoma elasticum) and epilepsy].
    Journal de genetique humaine, 1973, Volume: 21, Issue:1

    Topics: Adult; Epilepsy; Favism; Genetic Counseling; Glucosephosphate Dehydrogenase Deficiency; Humans; Kidn

1973
The role of antiepileptic blood levels in the treatment of patients with epilepsy.
    Journal of the Iowa Medical Society, 1973, Volume: 63, Issue:9

    Topics: Adult; Drug Therapy, Combination; Epilepsy; Female; Humans; Middle Aged; Phenobarbital; Phenytoin; P

1973
Diphenylhydantoin and selected congenital malformations.
    The New England journal of medicine, 1973, Nov-15, Volume: 289, Issue:20

    Topics: Abnormalities, Drug-Induced; Adult; Birth Weight; Congenital Abnormalities; Epilepsy; Female; Fetus;

1973
Editorial: Teratogenesis and antiepileptic drugs.
    The New England journal of medicine, 1973, Nov-15, Volume: 289, Issue:20

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Congenital Abnormalities; Epi

1973
Failure to observe dosage instructions in patients with epilepsy. The short-term effect of a daily dispenser.
    Acta neurologica Scandinavica, 1973, Volume: 49, Issue:3

    Topics: Adolescent; Adult; Chromatography, Gas; Drug Packaging; Drug Therapy, Combination; Epilepsy; Female;

1973
Abnormalities in liver function tests during long-term diphenylhydantoin therapy in epileptic out-patients.
    Acta medica Scandinavica, 1973, Volume: 194, Issue:4

    Topics: Adolescent; Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Bilirubin; Calcium; Epilepsy; F

1973
[Editorial: Antiepileptic agents--folic acid].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1973, Jun-30, Volume: 93, Issue:18

    Topics: Anemia, Macrocytic; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; P

1973
The influence of phenobarbital and diphenylhydantoin on some blood cation transport systems in epileptics.
    Revue roumaine de neurologie, 1973, Volume: 10, Issue:5

    Topics: Adolescent; Adult; Aged; Biological Transport; Brain; Child; Child, Preschool; Electrolytes; Epileps

1973
A rapid method for the estimation of anti-epileptic drugs in blood serum by gas-liquid chromatography.
    Clinica chimica acta; international journal of clinical chemistry, 1973, Nov-15, Volume: 48, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Epilepsy; Ethosuximide; Evaluation Studies as T

1973
The teratological effects of anticonvulsants and the effects on pregnancy and birth.
    European neurology, 1973, Volume: 10, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cleft Lip; Cleft Palate; Cyclohe

1973
Lymphocytosis in the first-trimester placenta of a mother taking diphenylhydantoin.
    The New England journal of medicine, 1973, Oct-18, Volume: 289, Issue:16

    Topics: Abortion, Induced; Adult; Epilepsy; Female; Humans; Lymphocytosis; Phenytoin; Placenta; Placenta Dis

1973
The orienting reflex in epilepsy: electrographic data concerning the effect of antiepileptic treatment upon the interictal changes in the orienting reflex. Human data.
    Revue roumaine de neurologie, 1973, Volume: 10, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Brain; Cardiovascular System; Child; Drug Combinations; Electroc

1973
[Editorial: Teratogenic risk of the anti-epileptic therapeutics].
    La Nouvelle presse medicale, 1973, Nov-17, Volume: 2, Issue:41

    Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Epilepsy; Female; Humans; Mice; Phenytoin; Ra

1973
Influence of phenobarbital and diphenylhydantoin on plasma carbamazepine levels in patients with epilepsy.
    Acta neurologica Scandinavica, 1973, Volume: 49, Issue:4

    Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Depression, Chemical; Drug Therapy, Combination; Epil

1973
Effect of anticonvulsive drugs on folate absorption and the cerebrospinal folate pump.
    Scandinavian journal of haematology, 1973, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Aged; Carbamazepine; Depression, Chemical; Epilepsy; Female; Folic Acid; Folic Ac

1973
[Folic acid and folate values in plasma and whole blood].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1973, Oct-10, Volume: 93, Issue:28

    Topics: Acute Disease; Barbiturates; Contraceptives, Oral; Epilepsy; Ethanol; Female; Folic Acid; Folic Acid

1973
Minor epileptic status with contractures.
    Proceedings of the Royal Society of Medicine, 1973, Volume: 66, Issue:11

    Topics: Child; Contracture; Electroencephalography; Epilepsy; Female; Humans; Intelligence; Phenytoin; Predn

1973
[Complications of medical therapy for epilepsy in children and adolescents].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1973, Volume: 73, Issue:11

    Topics: Anticonvulsants; Child; Diplopia; Drug Hypersensitivity; Drug Therapy, Combination; Epilepsy; Headac

1973
Correlation of anticonvulsant levels in human plasma and epileptogenic brain.
    Transactions of the American Neurological Association, 1973, Volume: 98

    Topics: Animals; Brain; Cerebral Cortex; Electroencephalography; Epilepsy; Frontal Lobe; Humans; Phenobarbit

1973
[Incompatibility of dilantin with isonicotinic acid hydrazides].
    Klinicheskaia meditsina, 1973, Volume: 51, Issue:9

    Topics: Adult; Drug Incompatibility; Epilepsy; Female; Humans; Isoniazid; Male; Middle Aged; Phenytoin; Trig

1973
Clonazepam in the treatment of epilepsy.
    Proceedings of the Australian Association of Neurologists, 1973, Volume: 10, Issue:0

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepinones; Chlorobenzenes; Chromatography, Gas; Drug Int

1973
Diphenylhydantoin dosage.
    Proceedings of the Australian Association of Neurologists, 1973, Volume: 10, Issue:0

    Topics: Adolescent; Adult; Age Factors; Body Weight; Child; Chromatography, Gas; Drug Interactions; Epilepsy

1973
[Hemostasis in epileptic patients treated with anticonvulsant drugs].
    Acta neurologica latinoamericana, 1973, Volume: 19, Issue:1-4

    Topics: Adolescent; Adult; Aged; Blood Coagulation Disorders; Blood Coagulation Factors; Child; Drug Evaluat

1973
Plasma disappearance of transplacentally transferred diphenylhydantoin in the newborn studied by mass fragmentography.
    Clinical pharmacology and therapeutics, 1974, Volume: 15, Issue:1

    Topics: Adult; Deuterium; Epilepsy; Female; Half-Life; Humans; Infant, Newborn; Kinetics; Male; Mass Spectro

1974
Emergency management of the patient with seizures. 1. Generalized status epilepticus.
    Postgraduate medicine, 1974, Volume: 55, Issue:2

    Topics: Airway Obstruction; Anesthesia, General; Anticonvulsants; Blood Pressure Determination; Blood Specim

1974
The influence of diphenylhydantoin on primidone metabolism.
    Archives of neurology, 1974, Volume: 30, Issue:3

    Topics: Adult; Biotransformation; Chromatography, Gas; Drug Interactions; Enzyme Induction; Epilepsy; Female

1974
[Letter: Diphenylhydantoins and teratogenic hazards].
    La Nouvelle presse medicale, 1974, Jan-12, Volume: 3, Issue:2

    Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications

1974
[Letter: Teratogenic hazards in antiepileptic therapy].
    La Nouvelle presse medicale, 1974, Jan-12, Volume: 3, Issue:2

    Topics: Abnormalities, Drug-Induced; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Preg

1974
Serum copper levels and diphenylhydantoin.
    American journal of clinical pathology, 1974, Volume: 61, Issue:4

    Topics: Ceruloplasmin; Chromatography, Gas; Copper; Drug Interactions; Epilepsy; Humans; Phenytoin; Spectrum

1974
Brain damage after lithium and phenytoin.
    British medical journal, 1974, Mar-09, Volume: 1, Issue:5905

    Topics: Brain Diseases; Cerebellar Ataxia; Epilepsy; Female; Humans; Lithium; Phenytoin; Purkinje Cells

1974
Calcium metabolism in elderly epileptic patients during anticonvulsant therapy.
    Journal of the American Geriatrics Society, 1974, Volume: 22, Issue:5

    Topics: Aged; Alkaline Phosphatase; Calcium; Cerebrovascular Disorders; Drug Therapy, Combination; Epilepsy;

1974
Infants exposed in utero to antiepileptic drugs. A prospective study.
    American journal of diseases of children (1960), 1974, Volume: 127, Issue:5

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro

1974
Letter: Anticonvulsant drugs and congenital abnormalities.
    American journal of diseases of children (1960), 1974, Volume: 127, Issue:5

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetus; Fingers; Humans; Infant; Nail

1974
Pharmacology for the pediatrician. Noncompliance contributing to apparent drug failure in status epilepticus.
    Pediatrics, 1974, Volume: 53, Issue:6

    Topics: Anticonvulsants; Benzodiazepinones; Child; Chlorobenzenes; Diazepam; Epilepsy; Ethosuximide; Female;

1974
Ulcerative colitis, colitic spondylitis and associated apical pulmonary fibrosis.
    Proceedings of the Royal Society of Medicine, 1974, Volume: 67, Issue:5

    Topics: Arthritis; Barium Sulfate; Colitis, Ulcerative; Epilepsy; Humans; Male; Middle Aged; Phenytoin; Pulm

1974
Intravenous glucose tolerance during treatment with phenytoin.
    Acta neurologica Scandinavica, 1974, Volume: 50, Issue:2

    Topics: Blood Glucose; Epilepsy; Glucose Tolerance Test; Humans; Insulin; Phenytoin

1974
Decrease in serum diphenylhydantoin levels after withdrawal of phenobarbital in epileptics treated with both drugs.
    The Tohoku journal of experimental medicine, 1974, Volume: 112, Issue:2

    Topics: Child; Child, Preschool; Chromatography, Gas; Epilepsy; Female; Humans; Male; Phenobarbital; Phenyto

1974
Serum levels of diphenylhydantoin and phenobarbital in epileptic children receiving diphenylhydantoin, phenobarbital and-or mysoline.
    The Tohoku journal of experimental medicine, 1974, Volume: 112, Issue:2

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; Phenytoi

1974
Serum anticonvulsant concentrations in epileptic patients with mental symptoms. A preliminary report.
    The British journal of psychiatry : the journal of mental science, 1974, Volume: 124, Issue:0

    Topics: Adolescent; Adult; Aged; Epilepsy; Female; Humans; Intelligence; Male; Mental Disorders; Middle Aged

1974
[Ethnic differences in serum phenytoin levels].
    Ugeskrift for laeger, 1974, Aug-26, Volume: 136, Issue:35

    Topics: Adolescent; Adult; Child; Child, Preschool; Denmark; Epilepsy; Ethnicity; Female; Greenland; Humans;

1974
Clinical significance of generic inequivalence of three different pharmaceutical preparations of phenytoin.
    European journal of clinical pharmacology, 1974, Volume: 7, Issue:2

    Topics: Acids; Adult; Biopharmaceutics; Epilepsy; Female; Humans; Male; Middle Aged; Particle Size; Phenytoi

1974
Development of anticonvulsant osteomalacia in epileptic patients on phenytoin treatment.
    Acta neurologica Scandinavica, 1974, Volume: 50, Issue:4

    Topics: Adult; Aged; Alkaline Phosphatase; Bone and Bones; Calcium; Epilepsy; Female; Humans; Male; Middle A

1974
Editorial: Congenital malformations and antiepileptic drugs.
    Canadian Medical Association journal, 1974, Aug-17, Volume: 111, Issue:4

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fe

1974
Effect of diphenylhydantoin on hepatic drug hydroxylation.
    European journal of clinical pharmacology, 1974, Jul-26, Volume: 7, Issue:4

    Topics: Adult; Antipyrine; Bilirubin; Colorimetry; Creatinine; Epilepsy; Half-Life; Humans; Hydroxylation; J

1974
Inhibition of high-affinity glial uptake of 14C-glutamate by folate.
    Nature, 1974, Aug-02, Volume: 250, Issue:465

    Topics: Animals; Carbon Radioisotopes; Epilepsy; Extracellular Space; Folic Acid; Ganglia, Spinal; Glutamate

1974
Isolation of 1,4-androstadiene-3,17-dione from urine of an epileptic boy.
    Journal of steroid biochemistry, 1974, Volume: 5, Issue:3

    Topics: Adolescent; Androstenes; Chromatography, Gas; Chromatography, Paper; Chromatography, Thin Layer; Cir

1974
Stress convulsions.
    Archives of neurology, 1974, Volume: 31, Issue:3

    Topics: Adolescent; Adult; Affect; Age Factors; Child; Electroencephalography; Epilepsy; Evaluation Studies

1974
Movement disorder as a manifestation of diphenylhydantoin intoxication.
    Neurology, 1974, Volume: 24, Issue:1

    Topics: Adult; Ataxia; Athetosis; Chorea; Epilepsy; Female; Humans; Middle Aged; Nystagmus, Pathologic; Phen

1974
Delivery of anticonvulsant drug therapy in epileptic patients assessed by plasma level analyses.
    Neurology, 1974, Volume: 24, Issue:7

    Topics: Adolescent; Adult; Child; Chromatography, Gas; Drug Therapy; Electroencephalography; Epilepsy; Human

1974
[Treatment of epilepsy with tegretol (5-carbamyl-5H-dibenzo (b,f) azepine)].
    No to shinkei = Brain and nerve, 1965, Volume: 17, Issue:8

    Topics: Adolescent; Adult; Anticonvulsants; Azepines; Child; Chlordiazepoxide; Electroencephalography; Epile

1965
Electrophysiological studies of the action of intravenous diphenylhydantoin (Dilantin).
    Neurology, 1966, Volume: 16, Issue:10

    Topics: Animals; Cerebral Cortex; Electroencephalography; Epilepsy; Haplorhini; Injections, Intravenous; Phe

1966
The development of Hodgkin's disease and lymphoma during anticonvulsant therapy.
    Blood, 1966, Volume: 28, Issue:3

    Topics: Adult; Aged; Anticonvulsants; Child; Epilepsy; Epilepsy, Absence; Epilepsy, Post-Traumatic; Epilepsy

1966
Lack of significant binding of L-triiodothyronine by thyroxine-binding globulin in vivo as demonstrated by acute disappearance of 131-I-labeled triiodothyronine.
    The Journal of clinical investigation, 1966, Volume: 45, Issue:8

    Topics: Adolescent; Adult; Aged; Epilepsy; Estrogens; Female; Hepatitis; Humans; Hyperthyroidism; Hypothyroi

1966
Controlled evaluation of primidone and diphenyllhydantoin sodium. Comparative anticonvulsant efficacy and toxicity in children.
    JAMA, 1968, May-20, Volume: 204, Issue:8

    Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; Human

1968
[Status elepticus].
    Praxis, 1967, Jun-01, Volume: 56, Issue:22

    Topics: Barbiturates; Diazepam; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenytoin

1967
[The treatment of epilepsy with falepsin. A report of the clinical experience gained].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1968, Volume: 20, Issue:10

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Epilepsy; Epilepsy, Tonic-Clonic;

1968
Precordial pain in an epileptic relic by dilantin.
    The Johns Hopkins medical journal, 1969, Volume: 124, Issue:1

    Topics: Angina Pectoris; Diagnosis, Differential; Electrocardiography; Epilepsy; Female; Humans; Middle Aged

1969
The metabolic significance of thyroxine-binding globulin. Studies in a family with decreased thyroxine-binding globulin.
    Acta endocrinologica, 1969, Volume: 61, Issue:1

    Topics: Adolescent; Adult; Aged; Basal Metabolism; Blood Protein Disorders; Child; Epilepsy; Female; Humans;

1969
Studies of anticonvulsant levels in epileptics. I. Serum diphenylhydantoin concentrations in a group of medically indigent outpatients.
    Acta neurologica Scandinavica, 1969, Volume: 45, Issue:1

    Topics: Anticonvulsants; Barbiturates; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medical Indigency; Neurolog

1969
Diphenylhydantoin as an anticonvulsant: protein binding and fluctuation of the serum and cerebrospinal fluid levels in forty mentally subnormal epileptics.
    Journal of mental deficiency research, 1969, Volume: 13, Issue:4

    Topics: Epilepsy; Epilepsy, Tonic-Clonic; Humans; Intellectual Disability; Phenytoin; Protein Binding; Seizu

1969
Effects of diphenylhydantoin (Dilantin) withdrawal on non-epileptics: preliminary report.
    Current therapeutic research, clinical and experimental, 1970, Volume: 12, Issue:1

    Topics: Adult; Aged; Electroencephalography; Epilepsy; Humans; Middle Aged; Phenytoin; Substance Withdrawal

1970
Treatment of status epilepticus.
    Developmental medicine and child neurology, 1970, Volume: 12, Issue:3

    Topics: Child; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Humans; Male; P

1970
Placental transfer and neonatal elimination of diphenylhydantoin.
    American journal of obstetrics and gynecology, 1971, Mar-15, Volume: 109, Issue:6

    Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Infant, Newborn; Lon

1971
Unwanted effects of anticonvulsant drugs.
    Developmental medicine and child neurology, 1971, Volume: 13, Issue:1

    Topics: Child; Child, Preschool; Epilepsy; Humans; Long-Term Care; Phenytoin

1971
Plasma protein binding, plasma concentrations, and effects of diphenylhydantoin in man.
    Annals of the New York Academy of Sciences, 1971, Jul-06, Volume: 179

    Topics: Blood; Blood Proteins; Epilepsy; Epilepsy, Tonic-Clonic; Female; Humans; Hyperbilirubinemia; In Vitr

1971
[Studies of the effect of 5,5-diphenylhydantoin on the bioelectric activity of the brain in epilepsy].
    Neurologia i neurochirurgia polska, 1971, Volume: 5, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Brain; Electroencephalography; Epilepsy; Epilepsy, Absence;

1971
[Results of treatment of epilepsy in children up to 14 years of age].
    Neurologia i neurochirurgia polska, 1971, Volume: 5, Issue:3

    Topics: Adolescent; Age Factors; Barbiturates; Child; Child, Preschool; Diazepam; Drug Synergism; Electroenc

1971
Epilepsia partialis continua.
    Epilepsia, 1971, Volume: 12, Issue:3

    Topics: Adult; Brain Diseases; Brain Stem; Electroencephalography; Epilepsies, Partial; Epilepsy; Hematoma,

1971
Relationship between paroxysmal atrial tachycardia and paroxysmal cerebral discharges.
    Bulletin of the Los Angeles neurological societies, 1972, Volume: 37, Issue:1

    Topics: Anticonvulsants; Child, Preschool; Electrocardiography; Electroencephalography; Epilepsy; Humans; Hy

1972
Folate deficiency after anticonvulsant drugs: an effect of hepatic enzyme induction?
    British medical journal, 1972, Jan-29, Volume: 1, Issue:5795

    Topics: Adipates; Adolescent; Anticonvulsants; Child; Enzyme Induction; Epilepsy; Female; Folic Acid; Folic

1972
Unplanned pregnancy in an epileptic.
    British medical journal, 1972, Mar-11, Volume: 1, Issue:5801

    Topics: Amenorrhea; Contraceptives, Oral; Epilepsy; Ethinyl Estradiol; Female; Folic Acid; Gluconates; Human

1972
[The diffusion of diphenylhydantoin across the cellophane membrane of the artificial kidney in a patient with uremia and epilepsy].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1972, Mar-28, Volume: 61, Issue:13

    Topics: Cellophane; Diffusion; Epilepsy; Humans; Kidney Diseases, Cystic; Kidney Failure, Chronic; Kidneys,

1972
Minor epileptic status.
    Developmental medicine and child neurology, 1972, Volume: 14, Issue:1

    Topics: Brain Diseases; Child; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Phenytoin; Primidone

1972
[Teratogenic effect of phenytoin].
    Nederlands tijdschrift voor geneeskunde, 1972, Jan-15, Volume: 116, Issue:3

    Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Infant, Newborn; Phe

1972
[Vitamins and medicines. New and complicated relations].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1972, Mar-30, Volume: 92, Issue:9

    Topics: Arthritis, Rheumatoid; Aspirin; Drug Combinations; Drug Interactions; Epilepsy; Humans; Phenytoin; P

1972
Immunological abnormalities and hydantoins.
    British medical journal, 1972, Jun-03, Volume: 2, Issue:5813

    Topics: Adult; Agammaglobulinemia; Antigens; Epilepsy; Female; Humans; Hydantoins; Immunity, Cellular; Immun

1972
Antiepileptic drug concentrations in plasma. Clinical evaluation of 321 estimations in 237 unselected patients.
    Acta neurologica Scandinavica, 1972, Volume: 48, Issue:2

    Topics: Carbamazepine; Chromatography, Gas; Chromatography, Thin Layer; Epilepsy; Humans; Methods; Phenobarb

1972
Anticonvulsant hypocalcaemia.
    British medical journal, 1972, Jun-24, Volume: 2, Issue:5816

    Topics: Calcium; Epilepsy; Humans; Hypocalcemia; Phenobarbital; Phenytoin

1972
Treatment of epilepsy in the light of determinations of the blood levels of anticonvulsants.
    Polish medical journal, 1972, Volume: 11, Issue:1

    Topics: Adult; Child; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Primidone

1972
Factors involved in an outbreak of phenytoin intoxication.
    Journal of the neurological sciences, 1972, Volume: 16, Issue:4

    Topics: Australia; Calcium; Capsules; Epilepsy; Evaluation Studies as Topic; Humans; Lactose; Pharmaceutic A

1972
Osteomalacia accompanying chronic anticonvulsant therapy.
    The Journal of clinical endocrinology and metabolism, 1972, Volume: 35, Issue:3

    Topics: Adolescent; Alkaline Phosphatase; Biopsy; Bone and Bones; Calcium; Epilepsy; Humans; Hydroxyproline;

1972
Diphenylhydantoin and epilepsy management.
    Annals of internal medicine, 1972, Volume: 77, Issue:3

    Topics: Administration, Oral; Epilepsy; Humans; Injections, Intramuscular; Injections, Intravenous; Phenobar

1972
Coarse facies, calvarial thickening and hyperphosphatasia after anticonvulsants.
    The New England journal of medicine, 1972, Oct-05, Volume: 287, Issue:14

    Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Child; Epilepsy; Facial Expression; Female; Humans; Ph

1972
Drug interactions. 3. Therapeutic implications of enzyme induction.
    Pediatrics, 1972, Volume: 50, Issue:3

    Topics: Age Factors; Child; Child, Preschool; Drug Interactions; Drug Synergism; Enzyme Induction; Epilepsy;

1972
[Speech disorders in children with cerebral convulsions].
    Klinische Padiatrie, 1972, Volume: 184, Issue:1

    Topics: Adolescent; Barbiturates; Carbamazepine; Drug Hypersensitivity; Electroencephalography; Epilepsy; Et

1972
Diphenylhydantoin risks in children.
    JAMA, 1972, May-01, Volume: 220, Issue:5

    Topics: Child; Child, Preschool; Epilepsy; Humans; Medication Errors; Nervous System Diseases; Phenytoin; Su

1972
Status epilepticus as a complication of intrathecal fluorescein. Case report.
    Journal of neurosurgery, 1972, Volume: 36, Issue:5

    Topics: Aged; Cerebrospinal Fluid Rhinorrhea; Contrast Media; Epilepsy; Fluoresceins; Glucocorticoids; Human

1972
Abdominal epilepsy.
    JAMA, 1972, Oct-02, Volume: 222, Issue:1

    Topics: Abdomen; Age Factors; Child; Electroencephalography; Epilepsy; Humans; Nausea; Pain; Phenytoin; Prog

1972
Febrile convulsions in early childhood.
    British medical journal, 1972, Aug-12, Volume: 3, Issue:5823

    Topics: Child, Preschool; Epilepsy; Fever; Hospitalization; Humans; Phenobarbital; Phenytoin; Seizures

1972
Checking compliance of epileptic patients.
    The New England journal of medicine, 1972, Nov-02, Volume: 287, Issue:18

    Topics: Adolescent; Anticonvulsants; Epilepsy; Humans; Phenobarbital; Phenytoin

1972
Latent osteomalacia in epileptic patients on anticonvulsants.
    British medical journal, 1972, Sep-23, Volume: 3, Issue:5829

    Topics: Adult; Bone and Bones; Calcium; Epilepsy; Female; Humans; Male; Middle Aged; Minerals; Osteomalacia;

1972
Folate deficiency in malnutrition, malabsorption, and during phenytoin treatment diagnosed by determination of serine synthesis in lymphocytes.
    European journal of clinical investigation, 1972, Volume: 2, Issue:5

    Topics: Adult; Aged; Anemia; Carbon Isotopes; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficie

1972
Effect of a delayed-action phenytoin preparation on blood phenytoin concentration.
    Journal of neurology, neurosurgery, and psychiatry, 1972, Volume: 35, Issue:5

    Topics: Chromatography, Gas; Delayed-Action Preparations; Epilepsy; Humans; Phenytoin

1972
Epilepsy in multiple sclerosis.
    Journal of the neurological sciences, 1972, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Barbiturates; Basal Ganglia; Carbamazepine; Cerebral Cortex; Demyelinating Diseas

1972
Serum folic acid and phenytoin levels in permanently hospitalized epileptic patients receiving anticonvulsant drug therapy.
    The Medical journal of Australia, 1971, Aug-14, Volume: 2, Issue:7

    Topics: Central Nervous System Diseases; Epilepsy; Folic Acid; Folic Acid Deficiency; Hospitalization; Human

1971
Motor nerve conduction velocity during diphenylhydantoin intoxication.
    Acta neurologica Scandinavica, 1971, Volume: 47, Issue:3

    Topics: Depression, Chemical; Electric Stimulation; Epilepsy; Evoked Potentials; Humans; Neural Conduction;

1971
Concurrent administration of phenobarbital and diphenylhydantoin: lack of an interference effect.
    Neurology, 1971, Volume: 21, Issue:4

    Topics: Adolescent; Adult; Child; Chronic Disease; Drug Antagonism; Epilepsy; Humans; Phenobarbital; Phenoth

1971
Diphenylhydantoin (Dilatin) and phenobarbital blood levels in epileptic children.
    Neurology, 1971, Volume: 21, Issue:8

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Chromatography, Gas; Electroencephalogr

1971
[Treatment of epilepsy in the light of the determination of the anticonvulsant blood level].
    Neurologia i neurochirurgia polska, 1971, Volume: 5, Issue:3

    Topics: Administration, Oral; Age Factors; Anticonvulsants; Drug Synergism; Epilepsy; Humans; Phenobarbital;

1971
[Effect of 5,5-diphenylhydantoin and pneumoencephalography on urinary excretion of 5-hydroxyindoloacetic acid, a serotonin metabolite, and serum ceruloplasmin activity in epileptics].
    Neurologia i neurochirurgia polska, 1971, Volume: 5, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Ceruloplasmin; Epilepsy; Female; Humans; Hydroxyindoleaceti

1971
[Treatment of epilepsy with a combination of anticonvulsants in a group refractory to previously used drugs].
    Neurologia i neurochirurgia polska, 1971, Volume: 5, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Barbiturates; Child; Drug Synergism; Drug Tolerance; Epile

1971
The rapid quantitative determination of diphenyl hydantoin in plasma, serum, and whole blood of patients with epilepsy.
    Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 34, Issue:1

    Topics: Chloroform; Epilepsy; Humans; Ketones; Methods; Phenytoin; Solubility; Spectrophotometry

1971
Variations of serum diphenylhydantoin concentrations in epileptic out-patients.
    European neurology, 1971, Volume: 5, Issue:5

    Topics: Adolescent; Adult; Aged; Blood Proteins; Body Weight; Drug Synergism; Epilepsy; Female; Humans; Male

1971
[Clinical and pharmacodynamic correlations of phenobarbital (PB) and diphenylhydantoin (DPH) in the treatment of infantile epilepsy].
    Minerva pediatrica, 1971, Dec-15, Volume: 23, Issue:50

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Infant; Phenobarbital; Phenytoin

1971
Metabolite(s) of diphenylhydantoin in human plasma inhibit(s) the pentose phosphate pathway of leukocytes.
    Pharmacology, 1971, Volume: 6, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Aged; Blood Glucose; Body Weight; Child, Preschool; Epileps

1971
Bone density in patients receiving long-term anticonvulsant therapy.
    Acta neurologica Scandinavica, 1971, Volume: 47, Issue:5

    Topics: Absorptiometry, Photon; Adult; Alkaline Phosphatase; Anticonvulsants; Calcium; Carbamazepine; Epilep

1971
[3 cases of malignant lymphoma or pseudolymphoma in epileptics treated with diphenylhydantoin].
    Schweizerische medizinische Wochenschrift, 1971, Dec-11, Volume: 101, Issue:49

    Topics: Adult; Epilepsy; Female; Hodgkin Disease; Humans; Lymphoma; Male; Phenytoin

1971
Folic acid concentrations in cerebrospinal fluid in relation to anticonvulsant drugs and cerebral atrophy.
    Acta psychiatrica Scandinavica, 1971, Volume: 47, Issue:2

    Topics: Adult; Anticonvulsants; Atrophy; Brain Diseases; Epilepsy; Female; Folic Acid; Humans; Male; Mental

1971
[Anticonvulsants. 4. Determination of phenytoin in plasma. Clinical studies].
    Lakartidningen, 1971, Oct-18, Volume: 68

    Topics: Adult; Chromatography, Gas; Epilepsy; Female; Humans; Male; Phenytoin

1971
Folate metabolism in epileptic and psychiatric patients.
    Journal of neurology, neurosurgery, and psychiatry, 1971, Volume: 34, Issue:6

    Topics: Adult; Antidepressive Agents; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Hum

1971
[Considerations apropos of drug treatment of 1,217 epileptic patients. 3: Study in relation to the drugs used].
    Revista paulista de medicina, 1971, Volume: 77, Issue:6

    Topics: Barbiturates; Drug Evaluation; Drug Synergism; Epilepsy; Humans; Phenytoin; Primidone

1971
Drug interactions: effect of methylphenidate on the disposition of diphenylhydantoin in man.
    Neurology, 1971, Volume: 21, Issue:11

    Topics: Adult; Drug Interactions; Epilepsy; Female; Half-Life; Humans; Male; Methylphenidate; Phenytoin

1971
[Onset of systemic lupus erythematosus during long term administration of diphenyl-hydantoin].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1971, Sep-10, Volume: 60, Issue:9

    Topics: Adult; Biopsy; Epilepsy; Humans; Kidney; Lupus Erythematosus, Systemic; Male; Phenytoin

1971
Musicogenic epilepsy. A case report.
    Acta neurologica Scandinavica. Supplementum, 1965, Volume: 13 Pt 2

    Topics: Adult; Chlordiazepoxide; Electroencephalography; Emotions; Epilepsy; Epilepsy, Temporal Lobe; Hearin

1965
A case report of evaluation and management of hyperplastic gingiva in epileptics caused by sodium dilantin therapy.
    West Virginia dental journal, 1966, Volume: 40, Issue:3

    Topics: Dentistry; Epilepsy; Gingival Hyperplasia; Phenytoin

1966
Recurrent ulcerative stomatitis and dilantin gingival fibromatosis.
    Journal of clinical stomatology conferences, 1966, Volume: 7, Issue:1

    Topics: Dentistry; Epilepsy; Fibromatosis, Gingival; Gingivitis, Necrotizing Ulcerative; Phenytoin

1966
[Gingival hyperplasia caused by Diphedan].
    Fogorvosi szemle, 1967, Volume: 60, Issue:1

    Topics: Adolescent; Adult; Child; Epilepsy; Female; Gingival Hyperplasia; Humans; Male; Phenytoin

1967
Management of gingival hyperplasia in patients receiving Dilantin therapy.
    Journal of the Indian Dental Association, 1967, Volume: 39, Issue:8

    Topics: Dentistry; Epilepsy; Gingival Hyperplasia; Phenytoin

1967
[On the pathomechanism of hydantoin-induced gingival hyperplasia].
    Fogorvosi szemle, 1968, Volume: 61, Issue:8

    Topics: Adolescent; Anticonvulsants; Child; Child, Institutionalized; Epilepsy; Female; Gingival Hyperplasia

1968
[Clinical statistical contribution on gingival hyperplasia caused by anticonvulsants].
    Rivista italiana di stomatologia, 1968, Volume: 23, Issue:10

    Topics: Adolescent; Adult; Barbiturates; Child; Epilepsy; Female; Gingival Hyperplasia; Histocytochemistry;

1968
Comparative neuronal mechanisms.
    Epilepsia, 1969, Volume: 10, Issue:2

    Topics: Action Potentials; Animals; Annelida; Anura; Axons; Cell Membrane; Electric Stimulation; Epilepsy; G

1969
[Modified technic for the treatment of gingival hyperplasia in epileptic patients].
    Istanbul Universitesi Dishekimligi Fakultesi dergisi = The journal of the Dental Faculty of Istanbul, 1969, Volume: 3, Issue:2

    Topics: Epilepsy; Gingival Hyperplasia; Phenytoin; Subgingival Curettage

1969
[Dentistry for epileptics].
    Tidning. Sveriges Tandlakarforbund, 1970, Sep-15, Volume: 62, Issue:18

    Topics: Dentistry; Epilepsy; Gingival Hyperplasia; Phenytoin

1970
A clinical study of serum primidone levels.
    Epilepsia, 1970, Volume: 11, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Biotransformation; Child; Child, Preschool; Chromatography,

1970
Interaction between phenobarbital and diphenylhydantoin in animals and in epileptic patients.
    Annals of the New York Academy of Sciences, 1971, Jul-06, Volume: 179

    Topics: Adolescent; Adult; Animals; Brain; Brain Chemistry; Child; Child, Preschool; Chromatography, Gas; Ep

1971
Epileptic nystagmus.
    Epilepsia, 1971, Volume: 12, Issue:2

    Topics: Adult; Chlordiazepoxide; Electroencephalography; Epilepsy; Female; Humans; Neurologic Examination; N

1971
[Etiology of hydantoin gingiva hyperplasia and of the recidives].
    ZWR, 1971, Oct-25, Volume: 80, Issue:20

    Topics: Epilepsy; Female; Gingival Hyperplasia; Gingivectomy; Humans; Male; Phenytoin

1971
Anticonvulsant drugs and folic acid in young mentally retarded epileptic patients. A study of serum folate, fit frequency and I.Q.
    Epilepsia, 1971, Volume: 12, Issue:3

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Ethosuximide; Female; Folic Acid; Human

1971
Self-induced television epilepsy.
    Epilepsia, 1971, Volume: 12, Issue:3

    Topics: Adolescent; Electroencephalography; Epilepsy; Ethosuximide; Female; Humans; Myoclonus; Phenytoin; Te

1971
Focal spike discharges in children, a longitudinal study.
    Acta paediatrica Scandinavica, 1966

    Topics: Adolescent; Aging; Central Nervous System Diseases; Cerebral Palsy; Cerebral Ventriculography; Child

1966
Osteomalacia with long-term anticonvulsant therapy in epilepsy.
    British medical journal, 1970, Oct-10, Volume: 4, Issue:5727

    Topics: Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Biopsy; Calcium; Enzyme Induction; Epileps

1970
Plasma protein binding of diphenylhydantoin in man.
    Acta pharmacologica et toxicologica, 1971, Volume: 29 Suppl 3

    Topics: Adult; Aspirin; Bilirubin; Blood Proteins; Carbon Isotopes; Epilepsy; Female; Humans; Hydrogen-Ion C

1971
Delayed phenytoin idiosyncrasy.
    British medical journal, 1969, Nov-22, Volume: 4, Issue:5681

    Topics: Ataxia; Epilepsy; Humans; Nystagmus, Pathologic; Phenytoin

1969
Studies on the glucaric acid pathway in the metabolism of D-glucuronic acid in mammals. V. Stimulatory effect of diphenylhydantoin and phenobarbital on the D-glucaric acid synthesis in man.
    Chemical & pharmaceutical bulletin, 1969, Volume: 17, Issue:12

    Topics: Adipates; Epilepsy; Hexoses; Humans; Phenobarbital; Phenytoin; Stimulation, Chemical

1969
Central effects of diphenylhydantoin (dilantin) in epileptic oligophrenics during phenobarbital-primidone withdrawal, sodium bicarbonate, and ammonium chloride administration.
    Behavioral neuropsychiatry, 1969, Volume: 1, Issue:8

    Topics: Adolescent; Adult; Ammonium Chloride; Bicarbonates; Epilepsy; Female; Humans; Hydrogen-Ion Concentra

1969
[Determination of diphenylhydantoin (DFH) in plasma in patients with epilepsy].
    Lakartidningen, 1969, Oct-13, Volume: 66

    Topics: Drug Synergism; Epilepsy; Humans; Methods; Phenytoin

1969
Lack of effect of diphenylhydantoin ingestion on vesical transitional epithelium in the rat.
    Journal of surgical oncology, 1969, Volume: 1, Issue:1

    Topics: Animals; Carcinogens; Carcinoma, Papillary; Epilepsy; Epithelium; Female; Humans; Male; Middle Aged;

1969
Central effect of diphenylhydantoin (Dilantin) in epileptic oligophrenics during phenobarbital-primidone withdrawal, sodium bicarbonate, and ammonium chloride administration.
    Behavioral neuropsychiatry, 1969, Volume: 1, Issue:8

    Topics: Adolescent; Adult; Ammonium Chloride; Bicarbonates; Epilepsy; Female; Humans; Hydrogen-Ion Concentra

1969
Supervision of epileptic patients taking phenytoin.
    British medical journal, 1970, Jan-17, Volume: 1, Issue:5689

    Topics: Adult; Epilepsy; Female; Hospitalization; Humans; Male; Middle Aged; Outpatient Clinics, Hospital; P

1970
Diphenylhydantoin intoxication. A complication of isoniazid therapy.
    The American review of respiratory disease, 1970, Volume: 101, Issue:3

    Topics: Adolescent; Adult; Animals; Biotransformation; Cats; Epilepsy; Female; Humans; Isoniazid; Male; Midd

1970
Treatment of status epilepticus in dogs with diazepam sodium.
    Journal of the American Veterinary Medical Association, 1970, Feb-15, Volume: 156, Issue:4

    Topics: Animals; Barbiturates; Diazepam; Dog Diseases; Dogs; Epilepsy; Female; Injections, Intravenous; Male

1970
Epileptics on phenytoin.
    British medical journal, 1970, May-02, Volume: 2, Issue:5704

    Topics: Epilepsy; Humans; Myocardial Infarction; Phenytoin

1970
Pseudolymphoma induced by diphenylhydantoin.
    The Journal of pediatrics, 1970, Volume: 76, Issue:4

    Topics: Child; Epilepsy; Humans; Lymphoma; Male; Phenytoin; Skull Fractures

1970
Classical hysterical seizures facilitated by anticonvulsant toxicity.
    Psychiatria clinica, 1970, Volume: 3, Issue:2

    Topics: Achondroplasia; Adolescent; Adult; Electroencephalography; Epilepsy; Female; Humans; Hysteria; Male;

1970
[Decentralized treatment and control of patients with epilepsy. 3-year material].
    Nordisk medicin, 1970, May-28, Volume: 83, Issue:22

    Topics: Adolescent; Adult; Age Factors; Ambulatory Care; Child; Child, Preschool; Electroencephalography; Ep

1970
Phenytoin tolerance tests.
    British medical journal, 1970, Jul-25, Volume: 3, Issue:5716

    Topics: Administration, Oral; Adult; Arrhythmias, Cardiac; Chromatography, Thin Layer; Drug Tolerance; Epile

1970
Folate and vitamin B12 in epilepsy.
    British medical journal, 1970, Sep-05, Volume: 3, Issue:5722

    Topics: Animals; Brain Chemistry; Cats; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenytoin; Rats

1970
Calvarial thickening after Dilantin medication.
    The American journal of roentgenology, radium therapy, and nuclear medicine, 1970, Volume: 110, Issue:1

    Topics: Adolescent; Adult; Age Factors; Epilepsy; Female; Humans; Male; Phenytoin; Radiography; Skull

1970
Diphenylhydantoin intoxication attendant to slow inactivation of isoniazid.
    Neurology, 1970, Volume: 20, Issue:7

    Topics: Animals; Ataxia; Cats; Drug Tolerance; Epilepsy; Genetics, Medical; Humans; Isoniazid; Nystagmus, Pa

1970
Passage of diphenylhydantoin across the placenta.
    JAMA, 1970, Jul-20, Volume: 213, Issue:3

    Topics: Adult; Epilepsy; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Phenytoin; Placenta

1970
[Case of tonic seizure].
    No to shinkei = Brain and nerve, 1970, Volume: 22, Issue:6

    Topics: Adult; Arm; Benzazepines; Diphenhydramine; Electroencephalography; Epilepsy; Humans; Injections, Int

1970
Disturbance of calcium metabolism by anticonvulsant drugs.
    British medical journal, 1970, Oct-10, Volume: 4, Issue:5727

    Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Calcium Metabolism Disorders; Enzyme

1970
[Phenytoin intoxication--an insidous complication in the treatment of epilepsy].
    Duodecim; laaketieteellinen aikakauskirja, 1970, Volume: 86, Issue:17

    Topics: Adult; Body Weight; Cerebellar Diseases; Child; Epilepsy; Female; Humans; Male; Movement Disorders;

1970
The clinical significance of microsomal enzyme induction in the therapy of epileptic patients.
    Annals of clinical research, 1970, Volume: 2, Issue:3

    Topics: Adult; Chromatography; Enzyme Induction; Epilepsy; Female; Humans; Male; Microsomes, Liver; Phenobar

1970
Micro-determination of serum phenobarbitone and diphenylhydantoin by gas-liquid chromatography.
    Clinica chimica acta; international journal of clinical chemistry, 1970, Volume: 30, Issue:1

    Topics: Adult; Anticonvulsants; Chromatography, Gas; Epilepsy; Humans; Indicators and Reagents; Methods; Mic

1970
Outbreak of anticonvulsant intoxication in an Australian city.
    British medical journal, 1970, Oct-31, Volume: 4, Issue:5730

    Topics: Australia; Calcium; Disease Outbreaks; Drug Compounding; Epilepsy; Humans; Lactose; Pharmaceutical V

1970
Diphenylhydantoin fatal hepatic necrosis (a review of literature and report of a case treated with exchange transfusion).
    The Alabama journal of medical sciences, 1970, Volume: 7, Issue:3

    Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Exchange Tran

1970
Elevated serum alkaline phosphatase levels in epilepsy during diphenylhydantoin therapy.
    The New England journal of medicine, 1970, Dec-17, Volume: 283, Issue:25

    Topics: Adolescent; Adult; Alkaline Phosphatase; Epilepsy; Humans; Middle Aged; Phenytoin

1970
'Idiopathic epilepsy'.
    The Practitioner, 1970, Volume: 205, Issue:227

    Topics: Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenytoin; Primidone; Prognosi

1970
Pseudolymphoma induced by diphenylhydantoin.
    The Journal of pediatrics, 1970, Volume: 77, Issue:6

    Topics: Epilepsy; Humans; Lymphoma; Phenytoin

1970
The value of phenytoin plasma levels in the treatment of epilepsy.
    The Medical journal of Australia, 1970, Dec-05, Volume: 2, Issue:23

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Middle Aged; Pheny

1970
The value of blood phenytoin estimations in management of epilepsy.
    Archives of disease in childhood, 1970, Volume: 45, Issue:244

    Topics: Child; Child, Preschool; Epilepsy; Humans; Phenytoin

1970
New developments in anticonvulsant therapy.
    Postgraduate medicine, 1970, Volume: 48, Issue:6

    Topics: Anticonvulsants; Epilepsy; Humans; Phenobarbital; Phenytoin

1970
Potentiation of the antiepileptic action of diphenylhydantoin by chlorothiazide congeners.
    The Indian journal of medical research, 1970, Volume: 58, Issue:10

    Topics: Animals; Chlorothiazide; Drug Synergism; Epilepsy; Female; Male; Phenytoin; Rats; Seizures

1970
Anticonvulsants and hemorrhagic diseases of the newborn infant.
    The Journal of pediatrics, 1970, Volume: 77, Issue:3

    Topics: Epilepsy; Female; Humans; Infant, Newborn; Phenytoin; Pregnancy; Pregnancy Complications; Vitamin K

1970
The distribution of plasma phenytoin levels in epileptic patients.
    Journal of neurology, neurosurgery, and psychiatry, 1970, Volume: 33, Issue:4

    Topics: Adult; Drug Tolerance; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Primidone

1970
Ammonium chloride as an adjuvant to diphenyl-hydantoin therapy, and bulk ions in the CSF and serum in forty mentally subnormal epileptics.
    Journal of mental deficiency research, 1970, Volume: 14, Issue:2

    Topics: Ammonium Chloride; Bicarbonates; Calcium; Carbon Dioxide; Chlorides; Epilepsy; Humans; Intellectual

1970
[Therapy of epilepsy in mentally retarded children. Neuropsychiatric disorders caused by diphenylhydantoin].
    Therapeutische Umschau. Revue therapeutique, 1970, Volume: 27, Issue:7

    Topics: Adolescent; Affective Symptoms; Ataxia; Child; Epilepsy; Humans; Intellectual Disability; Male; Musc

1970
Investigation of an outbreak of anticonvulsant intoxication.
    Proceedings of the Australian Association of Neurologists, 1970, Volume: 7

    Topics: Calcium; Epilepsy; Humans; Lactose; Pharmaceutical Vehicles; Phenytoin; Sulfates

1970
Aspects of diphenylhydantoin metabolism.
    Proceedings of the Australian Association of Neurologists, 1970, Volume: 7

    Topics: Anticonvulsants; Blood Proteins; Chemical Phenomena; Chemistry; Drug Antagonism; Drug Synergism; Dru

1970
Effects of diphenylhydantoin, pH and total carbon dioxide in the cerebrospinal fluid during sodium bicarbonate and ammonium chloride intake in forty mentally sub-normal epileptics.
    Journal of mental deficiency research, 1970, Volume: 14, Issue:1

    Topics: Acid-Base Equilibrium; Adolescent; Adult; Ammonium Chloride; Bicarbonates; Calcium; Carbon Dioxide;

1970
Ammonium chloride as an adjuvant to diphenylhydantoin therapy, and pH, base bicarbonate and sodium in the serum of forty mentally subnormal epileptics.
    Journal of mental deficiency research, 1970, Volume: 14, Issue:1

    Topics: Acid-Base Equilibrium; Ammonium Chloride; Bicarbonates; Chlorides; Epilepsy; Humans; Hydrogen-Ion Co

1970
P henobarbital-Dilantin treatment of the intrauterine patient.
    The Journal of reproductive medicine, 1970, Volume: 5, Issue:2

    Topics: Enzyme Induction; Epilepsy; Erythroblastosis, Fetal; Female; Fetal Diseases; Humans; Infant, Newborn

1970
[Status epilepticus].
    Neuropsihijatrija, 1970, Volume: 18, Issue:2

    Topics: Diazepam; Electroencephalography; Epilepsy; Humans; Phenytoin

1970
Elevated serum alkaline phosphatase levels in the epileptic patients treated with diphenylhydantoin.
    Folia psychiatrica et neurologica japonica, 1970, Volume: 24, Issue:3

    Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Epilepsy

1970
Effect of intraluminal pH on the absorption of pteroylmonoglutamic acid.
    British medical journal, 1971, Jan-16, Volume: 1, Issue:5741

    Topics: Bicarbonates; Epilepsy; Female; Folic Acid; Humans; Hydrogen-Ion Concentration; Intestinal Absorptio

1971
Severe bradykinesia as a manifestation of toxicity to antiepileptic medications.
    The Journal of pediatrics, 1971, Volume: 78, Issue:4

    Topics: Acetazolamide; Anticonvulsants; Child; Epilepsy; Ethosuximide; Humans; Male; Mental Processes; Movem

1971
Therapeutic dilantin levels.
    The New England journal of medicine, 1971, Apr-08, Volume: 284, Issue:14

    Topics: Epilepsy; Humans; Phenytoin

1971
Maternal folate deficiency and pregnancy wastage. IV. Effects of folic acid supplements, anticonvulsants, and oral contraceptives.
    American journal of obstetrics and gynecology, 1971, Feb-01, Volume: 109, Issue:3

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Anemia, Macrocytic; Anemia, Sickle Cell; Anemia,

1971
Value of blood phenytoin estimation in management of childhood epilepsy.
    Archives of disease in childhood, 1971, Volume: 46, Issue:247

    Topics: Child; Child, Preschool; Epilepsy; Humans; Infant; Phenytoin

1971
[Different adverse effects of phenytoin].
    Duodecim; laaketieteellinen aikakauskirja, 1971, Volume: 87, Issue:11

    Topics: Epilepsy; Hematologic Diseases; Humans; Phenytoin

1971
[Congenital abnormalities, cleft lip and cleft palate in particular, in children of epileptic mothers].
    Nederlands tijdschrift voor geneeskunde, 1971, Aug-14, Volume: 115, Issue:33

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Cleft Lip; Cleft Palate; Epilepsy; Fema

1971
Gas chromatographic assay of underivatized 5,5-diphenylhydantoin (dilantin) in plasma extracts.
    Clinical chemistry, 1971, Volume: 17, Issue:5

    Topics: Carbamazepine; Chloroform; Chromatography, Gas; Coma; Epilepsy; Humans; Hydrogen-Ion Concentration;

1971
Jejunal pH and folic acid.
    British medical journal, 1971, May-08, Volume: 2, Issue:5757

    Topics: Barbiturates; Epilepsy; Folic Acid; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Jejun

1971
Diphenylhydantoin: evidence for a central action.
    Life sciences. Pt. 1: Physiology and pharmacology, 1971, May-15, Volume: 10, Issue:10

    Topics: Action Potentials; Animals; Cats; Cerebral Cortex; Epilepsy; Penicillins; Phenytoin; Purkinje Cells

1971
The diagnostic and therapeutic use of diphenylhydantoin in the subictal state and non-epileptic dysphoria.
    International journal of neuropsychiatry, 1967, Volume: 3

    Topics: Adjustment Disorders; Antisocial Personality Disorder; Anxiety Disorders; Depression; Emotions; Epil

1967
ACNP--session on diphenylhydantoin: introductory remarks.
    International journal of neuropsychiatry, 1967, Volume: 3

    Topics: Epilepsy; Humans; Mental Disorders; Phenytoin

1967
The usefulness of diphenylhydantoin in treatment of non-epileptic emotional disorders.
    International journal of neuropsychiatry, 1967, Volume: 3

    Topics: Age Factors; Cell Membrane; Depression; Electroencephalography; Emotions; Epilepsy; Fear; Female; He

1967
[The anti-epileptic and psychotropic properties of carbamazepine (Tegretol)].
    L'union medicale du Canada, 1967, Volume: 96, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Dibenzazepines; Epilepsy; Female; Humans; Male; M

1967
[Present status of the treatment of epilepsy].
    Revista de neuro-psiquiatria, 1967, Volume: 30, Issue:3

    Topics: Anticonvulsants; Epilepsy; Phenytoin; Sodium

1967
Epileptic seizures in non-embolic cerebral infarction.
    Transactions of the American Neurological Association, 1967, Volume: 92

    Topics: Cerebrovascular Disorders; Epilepsy; Follow-Up Studies; Humans; Phenobarbital; Phenytoin

1967
Serum folate deficiency in children receiving anticonvulsant therapy.
    Pediatrics, 1968, Volume: 41, Issue:3

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Erythrocyte Coun

1968
[On the changes of conduction velocity of peripheral motor nerve fibers by dephenylhydantoin].
    Deutsche Zeitschrift fur Nervenheilkunde, 1968, Volume: 193, Issue:1

    Topics: Adolescent; Adult; Electrophysiology; Epilepsy; Female; Humans; Male; Middle Aged; Motor Activity; M

1968
Low specific gravity syndrome.
    Clinical chemistry, 1968, Volume: 14, Issue:5

    Topics: Adult; Anticonvulsants; Calcium; Chlorides; Chronic Disease; Creatinine; Epilepsy; Female; Humans; I

1968
[Clinical side effects of phenytoin therapy].
    Das Deutsche Gesundheitswesen, 1968, Apr-11, Volume: 23, Issue:15

    Topics: Adult; Epilepsy; Humans; Middle Aged; Phenytoin

1968
"Dilantin" overdosage.
    The Medical journal of Australia, 1968, Sep-21, Volume: 2, Issue:12

    Topics: Epilepsy; Humans; Phenytoin

1968
The neurologic hazards of diphenylhydantoin in childhood.
    The Journal of pediatrics, 1968, Volume: 73, Issue:5

    Topics: Adolescent; Ataxia; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Neurologic Mani

1968
"Dilantin" overdose.
    The Medical journal of Australia, 1968, Sep-14, Volume: 2, Issue:11

    Topics: Epilepsy; Humans; Phenytoin

1968
Folic acid deficiency from anticonvulsant therapy.
    Developmental medicine and child neurology, 1968, Volume: 10, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Folic Acid Defic

1968
[Course of epilepsy and significance of determination of phenytoin in the serum].
    Ceskoslovenska pediatrie, 1968, Volume: 23, Issue:9

    Topics: Child; Epilepsy; Humans; Phenobarbital; Phenytoin; Prognosis

1968
Comparison of blood levels with oral and intramuscular diphenylhydantoin.
    Neurology, 1968, Volume: 18, Issue:8

    Topics: Adult; Aged; Electroencephalography; Epilepsy; Female; Humans; Injections, Intramuscular; Male; Midd

1968
Management of epilepsy with diphenylhydantoin sodium. Dosage regulation for problem patients.
    JAMA, 1968, Mar-11, Volume: 203, Issue:11

    Topics: Adult; Antitubercular Agents; Ataxia; Drug Tolerance; Epilepsy; Hospitalization; Humans; Nystagmus,

1968
Diphenylhydantoin in emotional disorders.
    JAMA, 1968, May-06, Volume: 204, Issue:6

    Topics: Arrhythmias, Cardiac; Epilepsy; Humans; Mental Disorders; Migraine Disorders; Phenytoin; Tic Disorde

1968
Plasma hydroxyproline in epilepsy.
    Acta neurologica Scandinavica, 1968, Volume: 44, Issue:3

    Topics: Adolescent; Adult; Collagen; Connective Tissue; Epilepsy; Female; Humans; Hydroxyproline; Male; Meth

1968
Effect of phenytoin on the tryptophan load test.
    Acta paediatrica Scandinavica, 1968, Volume: 57, Issue:2

    Topics: Adolescent; Age Factors; Child; Child, Preschool; Diagnosis, Differential; Epilepsy; Female; Humans;

1968
[On the problem of the treatment of cerebral epilepsy during pregnancy, labor and puerperium].
    Zentralblatt fur Gynakologie, 1968, Nov-02, Volume: 90, Issue:44

    Topics: Anticonvulsants; Delivery, Obstetric; Epilepsy; Female; Humans; Obstetric Labor Complications; Pheno

1968
Dilantin dementia.
    Transactions of the American Neurological Association, 1968, Volume: 93

    Topics: Epilepsy; Humans; Mental Processes; Phenytoin

1968
[The necessary dosis of antiepileptic drugs in epileptic children during their growth period].
    Der Nervenarzt, 1968, Volume: 39, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Body Weight; Child; Child Development; Child, Pres

1968
Mental effects of anticonvulsants, and folic acid metabolism.
    Brain : a journal of neurology, 1968, Volume: 91, Issue:2

    Topics: Age Factors; Anemia, Macrocytic; Anticonvulsants; Brain; Epilepsy; Female; Folic Acid; Folic Acid De

1968
A quantitative study of the acute effects of diphenylhydantoin on the electroencephalogram of epileptic patients. Theoretical considerations for its use in the treatment of status epilepticus.
    Neurology, 1968, Volume: 18, Issue:11

    Topics: Adolescent; Adult; Central Nervous System; Computers; Electroencephalography; Epilepsy; Female; Huma

1968
[Changing of the photosensible threshold in the electroencephalogram by drugs acting in the central nervous system].
    Arztliche Forschung, 1968, May-10, Volume: 22, Issue:5

    Topics: Adolescent; Adult; Aged; Barbiturates; Central Nervous System; Child; Diazepam; Electroencephalograp

1968
The multiple system effects of diphenylhydantoin (Dilantin).
    Minnesota medicine, 1969, Volume: 52, Issue:2

    Topics: Epilepsy; Female; Humans; Middle Aged; Phenytoin

1969
Diphenylhydantoin gingival hyperplasia.
    American journal of diseases of children (1960), 1969, Volume: 117, Issue:3

    Topics: Adolescent; Child; Epilepsy; Female; Gingival Hyperplasia; Gingivectomy; Humans; Male; Middle Aged;

1969
[Effect of 5-5-sodium diphenylhydantoin on the gastric mucosa].
    Revista espanola de las enfermedades del aparato digestivo, 1969, Volume: 28, Issue:2

    Topics: Adult; Aged; Epilepsy; Female; Gastric Mucosa; Gastritis; Humans; Male; Middle Aged; Phenytoin

1969
Thin-layer chromatography of anticonvulsant drugs.
    Clinical chemistry, 1969, Volume: 15, Issue:3

    Topics: Anticonvulsants; Chromatography, Thin Layer; Epilepsy; Humans; Hydantoins; Methods; Phenobarbital; P

1969
Ten years EEG studies in epileptic children (two cases).
    Diseases of the nervous system, 1969, Volume: 30, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Emotions; Epilepsy; Humans; Mephobarbit

1969
[Control of diphenylhydantoin dosage in epileptic seizures by determination of the serum levels].
    Die Medizinische Welt, 1969, Mar-29, Volume: 13

    Topics: Adult; Epilepsy; Female; Humans; Male; Methods; Phenytoin

1969
[Permanent cerebellar damage through temporary overdase of hydantoin].
    Deutsche medizinische Wochenschrift (1946), 1969, Jun-20, Volume: 94, Issue:25

    Topics: Adult; Cerebellar Diseases; Chronic Disease; Electroencephalography; Epilepsy; Female; Humans; Pheny

1969
Use of diphenylhydantoin in epilepsy treatment.
    Developmental medicine and child neurology, 1969, Volume: 11, Issue:1

    Topics: Ataxia; Chemical and Drug Induced Liver Injury; Epilepsy; Humans; Necrosis; Nervous System Diseases;

1969
Increased metabolism of metyrapone in rats pretreated with diphenylhydantoin or phenobarbital.
    Endocrinology, 1969, Volume: 85, Issue:3

    Topics: Adrenal Glands; Animals; Biotransformation; Chromatography, Thin Layer; Enzyme Induction; Epilepsy;

1969
[Phenytoin dosage and preparation forms].
    Ugeskrift for laeger, 1969, May-08, Volume: 131, Issue:19

    Topics: Drug Compounding; Drug Synergism; Epilepsy; Humans; Phenytoin; Tablets

1969
Folic acid and anticonvulsive drugs.
    Archives of neurology, 1969, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Erythrocyte Count; Female; FIGLU Test; Folic Acid; Fol

1969
Clinical therapeutic conditioning in reading epilepsy.
    Neurology, 1969, Volume: 19, Issue:8

    Topics: Adolescent; Behavior Therapy; Electroencephalography; Epilepsy; Galvanic Skin Response; Humans; Male

1969
Nil nocere. Unusual hyperkinetic syndromes following diphenylhydantoin administration.
    Munchener medizinische Wochenschrift (1950), 1969, Aug-22, Volume: 111, Issue:34

    Topics: Adult; Epilepsy; Female; Humans; Hyperkinesis; Injections, Intravenous; Middle Aged; Phenytoin

1969
[Study on long-active effect of antiepileptic agents].
    No to shinkei = Brain and nerve, 1969, Volume: 21, Issue:7

    Topics: Adolescent; Adult; Chronic Disease; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Seizures

1969
[Serum phenytoin levels following intramuscular injection in relation to treatment of status epilepticus].
    Ugeskrift for laeger, 1965, Aug-12, Volume: 127, Issue:32

    Topics: Adolescent; Adult; Blood; Epilepsy; Humans; Injections, Intramuscular; Middle Aged; Phenytoin

1965
EFG activation of patients receiving phenothiazines and chlordiazepoxide.
    The Journal of nervous and mental disease, 1965, Volume: 141, Issue:1

    Topics: Adult; Anxiety; Cerebral Cortex; Chloralose; Chlordiazepoxide; Chlorpromazine; Depression; Electroen

1965
[Myasthenic syndrome as a rare complication of hydantoin treatment].
    Der Nervenarzt, 1965, Volume: 36, Issue:7

    Topics: Adult; Blood Sedimentation; Curare; Edrophonium; Electrocardiography; Electromyography; Epilepsy; Fe

1965
Studies of diphenylhydantoin metabolism.
    Transactions of the American Neurological Association, 1965, Volume: 90

    Topics: Blood; Epilepsy; Intestinal Absorption; Phenytoin

1965
[Association of pyrithioxin and diphenylhydantoin in the treatment of organic epileptic syndromes].
    Medicina clinica, 1965, Volume: 45, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Infant; Middle Aged;

1965
Significance of seizures in patients receiving psychotropic drugs.
    JAMA, 1965, Oct-18, Volume: 194, Issue:3

    Topics: Adult; Drug Hypersensitivity; Epilepsy; Humans; Male; Meprobamate; Phenytoin; Schizophrenia; Seizure

1965
Diphenylhydantoin toxicity; lymphadenopathy and low platelet count.
    Pediatrics, 1966, Volume: 37, Issue:2

    Topics: Adolescent; Blood Coagulation Disorders; Blood Platelet Disorders; Epilepsy; Humans; Lymphadenitis;

1966
Some causes of ineffectiveness of diphenylhydantoin.
    Archives of neurology, 1966, Volume: 14, Issue:5

    Topics: Aged; Blood; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin

1966
Fever. An unusual manifestation of epilepsy.
    Postgraduate medicine, 1966, Volume: 40, Issue:4

    Topics: Child; Epilepsy; Fever; Humans; Male; Phenytoin

1966
Intramuscular administration of phenytoin.
    Neurology, 1966, Volume: 16, Issue:3

    Topics: Epilepsy; Humans; Injections, Intramuscular; Phenytoin

1966
Depression of prahydroxylation of diphenylhydantoin by antituberculosis chemotherapy.
    Neurology, 1966, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Aged; Aminosalicylic Acids; Anticonvulsants; Ataxia; Cycloserine; Drug Incompatib

1966
Drug-induced systemic lupus erythematosus. Primidone as a possible cause.
    JAMA, 1966, Nov-07, Volume: 198, Issue:6

    Topics: Electroencephalography; Epilepsy; Female; Humans; Hydralazine; Hydroxychloroquine; Lupus Erythematos

1966
Enuresis and its relationship to electroencephalographic disturbances.
    The Journal of urology, 1966, Volume: 96, Issue:6

    Topics: Adolescent; Adult; Brain Diseases; Child; Child, Preschool; Electroencephalography; Enuresis; Epilep

1966