phenytoin and Aura
phenytoin has been researched along with Aura in 2565 studies
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "We sought to determine the effect of changing phenytoin therapy on bone mineral density (BMD) and 25-hydroxyvitamin D in patients with epilepsy." | 9.17 | Effect of switching hepatic enzyme-inducer antiepileptic drug to levetiracetam on bone mineral density, 25 hydroxyvitamin D, and parathyroid hormone in young adult patients with epilepsy. ( Geater, A; Leelawattana, R; Limapichat, K; Phabphal, K; Sathirapanya, P; Setthawatcharawanich, S, 2013) |
| "To evaluate the safety and tolerability of treatment with levetiracetam and determine the trough levels of levetiracetam in patients with traumatic brain injury (TBI) who are at high risk for posttraumatic epilepsy (PTE)." | 9.16 | Results of phase 2 safety and feasibility study of treatment with levetiracetam for prevention of posttraumatic epilepsy. ( Atabaki, SM; He, J; Herr, D; Klein, P; Levine, Z; McCarter, R; Natale, J; Nogay, C; Pearl, PL; Sandoval, F; Soldin, SJ; Trzcinski, S; Tsuchida, T; van den Anker, J, 2012) |
| "To evaluate topiramate (TPM) and phenytoin (PHT) monotherapy following rapid oral initiation in new-onset epilepsy." | 9.14 | Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new-onset epilepsy: a randomized double-blind clinical trial. ( Faught, E; Hulihan, J; Krumholz, A; Mao, L; Naritoku, D; Privitera, M; Ramsay, E; Schwarzman, L; Wiegand, F, 2010) |
| "To evaluate the efficacy and tolerability of the treatment with valproic acid (VPA) in patients with status epilepticus (SE) or acute repetitive seizures (ARS) comparing it with phenytoin (PHT) treatment." | 9.13 | Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin. ( Dabby, R; Gilad, R; Izkovitz, N; Lampl, Y; Rapoport, A; Sadeh, M; Weller, B, 2008) |
| "To evaluate the response to albendazole treatment in patients who had SSECTL and new onset seizures treated with antiepileptic drugs (AED) in a prospective clinical trial." | 9.13 | Albendazole therapy for single small enhancing CT lesions (SSECTL) in the brain in epilepsy. ( Chattopadhyay, A; Khandelwal, N; Sawhney, IM; Thussu, A, 2008) |
| " This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy." | 9.12 | Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021) |
| "The role of folic acid (5mg/day) in combination with oral hygiene measures (group II) vis-a-vis oral hygiene measures alone (group I) in prevention of phenytoin-induced gingival overgrowth was investigated in a one-year follow-up study on sixty, 8-13-year-old epileptic children receiving phenytoin." | 9.11 | Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect. ( Chawla, HS; Gauba, K; Goyal, A; Prasad, VN; Singhi, P, 2004) |
| "This study was designed to measure the effect of the addition of zonisamide on phenytoin pharmacokinetics under steady-state conditions in patients with epilepsy." | 9.11 | Lack of a clinically significant effect of zonisamide on phenytoin steady-state pharmacokinetics in patients with epilepsy. ( Garnett, WR; Levy, RH; Pan, WJ; Ragueneau-Majlessi, I; Rosenfeld, W; Schmerler, M; Shah, J, 2004) |
| "Remacemide hydrochloride is a low-affinity, non-competitive NMDA receptor channel blocker under investigation for the treatment of epilepsy." | 9.10 | Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 800 mg/day) in a B.I.D. regimen. ( Blume, WT; Guberman, A; Holdich, TA; Jones, MW; Lee, MA; Pillay, N; Veloso, F; Weaver, DF, 2002) |
| "Remacemide hydrochloride is a low-affinity, non-competitive N-methyl-D-aspartic acid (NMDA) receptor channel blocker, under investigation in epilepsy." | 9.10 | Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 1200 mg/day) in a Q.I.D. regimen. ( Betts, TA; Boddie, HG; Chadwick, DW; Crawford, PM; Holdich, TA; Lindstrom, P; Newman, PK; Soryal, I; Wroe, S, 2002) |
| "The authors assessed the effect of concomitant antiepileptic therapy on steady-state plasma concentrations of the new antiepileptic drug (AED) topiramate and the potential relation between topiramate plasma levels and side effects in a cohort of 116 patients with epilepsy." | 9.10 | Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs. ( Albani, F; Avoni, P; Baruzzi, A; Contin, M; Riva, R, 2002) |
| "To assess the extent to which adults with epilepsy were optimized and individualized on phenytoin monotherapy in the Western Cape, South Africa and to estimate the average optimized dose and serum phenytoin concentration, and the therapeutic range for this patient group." | 9.09 | Optimization of phenytoin therapy in adults with epilepsy in the Western Cape, South Africa. ( Folb, PI; Kies, BM; Seymour, MA; Valodia, PN, 1999) |
| "Changes in body weight were evaluated in 349 patients from a study comparing efficacy of add-on therapy with tiagabine (TGB), carbamazepine (CBZ) or phenytoin (PHT)." | 9.09 | Total percentage body weight changes during add-on therapy with tiagabine, carbamazepine and phenytoin. ( Bertrand, ME; Deaton, RL; Hogan, RE; Sommerville, KW, 2000) |
| "This prospective observational study explored the efficacy and tolerability of topiramate (TPM) in patients with refractory epilepsy attending a single outpatient clinic." | 9.09 | Topiramate in refractory epilepsy: a prospective observational study. ( Brodie, MJ; Sills, GJ; Stephen, LJ, 2000) |
| "The effects of temperature on binding characteristics of phenytoin (PHT) to serum proteins were determined in adult patients with epilepsy." | 9.09 | Effect of temperature on binding characteristics of phenytoin to serum proteins in monotherapy adult patients with epilepsy. ( Kanemaru, R; Kodama, H; Kodama, Y; Mitsuyama, Y; Shinozawa, S; Todaka, K, 2000) |
| "Fifty-four out-patients with epilepsy who had been taking phenytoin for more than one year were examined for gingival hyperplasia." | 9.08 | Phenytoin as a risk factor in gingival hyperplasia. ( Kolínová, M; Patzelová, V; Perlík, F; Zvárová, J, 1995) |
| "Our objective was to evaluate the patterns of malformations in children exposed in utero to phenytoin (DPH) and carbamazepine (CBZ) monotherapy, and to compare them prospectively with matched mother-child pairs exposed to nonteratogens, and to separate the effects of antiepileptic drugs (AEDs) from those of epilepsy by collecting groups of untreated epileptics and those treated with DPH and CBZ for conditions other than epilepsy." | 9.08 | Findings in children exposed in utero to phenytoin and carbamazepine monotherapy: independent effects of epilepsy and medications. ( Chitayat, D; Farkas, LD; Koren, G; Nulman, I; Scolnik, D, 1997) |
| "To examine the genetic polymorphism of CYP2C9 and CYP2C19 and its effect on the pharmacokinetics of phenytoin among 44 Japanese patients with epilepsy." | 9.08 | Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy. ( Furusho, K; Hashimoto, Y; Hattori, H; Inui, K; Odani, A; Otsuki, Y; Uwai, Y, 1997) |
| "To compare the effectiveness of monotherapy clobazam (CLB) to carbamazepine (CBZ) and phenytoin (PHT) in children with epilepsy." | 9.08 | Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy. ( , 1998) |
| "We measured the levels of estradiol (E2), total testosterone (TT) and free testosterone (FT) in 24 male patients with epilepsy receiving phenytoin (DPH), 21 male patients with epilepsy receiving cabamazepine (CBZ), 23 male epileptics receiving no treatment, and in 10 healthy age-matched male controls." | 9.07 | [Effects of phenytoin and cabamazepine on sex hormones in male patients with epilepsy: a controlled study]. ( Ma, S; Zhou, S, 1994) |
| "Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with behavioural measures before medication and after one and six months of treatment." | 9.07 | Psychiatric aspects of epilepsy in childhood treated with carbamazepine, phenytoin or sodium valproate: a random trial. ( Berg, I; Butler, A; Ellis, M; Foster, J, 1993) |
| "Twenty severely retarded institutionalized epileptic adults with phenytoin-induced gingival hyperplasia were divided into two groups and received a daily 3 mg capsule of either folic acid or lactose for 16 weeks in a randomized, double-blind, parallel study." | 9.07 | The administration of folic acid to institutionalized epileptic adults with phenytoin-induced gingival hyperplasia. A double-blind, randomized, placebo-controlled, parallel study. ( Beaver, WT; Bottomley, WK; Brown, RS; Di Stanislao, PT, 1991) |
| "Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with cognitive tests before medication and three subsequent times over a year." | 9.07 | Cognitive impairment in new cases of epilepsy randomly assigned to carbamazepine, phenytoin and sodium valproate. ( Berg, I; Butler, R; Forsythe, I; McGuire, R, 1991) |
| "Progabide, an experimental GABA-ergic antiepileptic drug, was given in a placebo-controlled double-blind cross-over trial to 19 adult patients with chronic partial epilepsy refractory to previous high-dose antiepileptic drug therapy." | 9.06 | Progabide for refractory partial epilepsy: a controlled add-on trial. ( Schmidt, D; Utech, K, 1986) |
| "In a double-blind trial of phenytoin for the prevention of postoperative epilepsy in craniotomy patients, epilepsy was observed in 7." | 9.05 | Postoperative epilepsy: a double-blind trial of phenytoin after craniotomy. ( Challen, RG; Frewin, DB; Hanieh, A; Hann, CS; North, JB; Penhall, RK, 1980) |
| "A double-blind trial of phenytoin therapy following craniotomy was performed to test the hypothesis that phenytoin is effective in reducing postoperative epilepsy." | 9.05 | Phenytoin and postoperative epilepsy. A double-blind study. ( Frewin, DB; Hanieh, A; North, JB; Penhall, RK; Taylor, WB, 1983) |
| "A double-blind cross-over trial between pheneturide and phenytoin in ninety-four outpatients with epilepsy is described." | 9.05 | A comparison of phenytoin and pheneturide in patients with epilepsy: a double-blind cross-over trial. ( Engler, C; English, JR; Fry, DE; Gawel, MJ; Gibberd, FB; Page, NG; Park, DM; Rose, FC; Scott, G, 1982) |
| "Despite the widespread use of phenytoin in the treatment of epilepsy, few studies have examined its effects on cognitive functioning." | 9.05 | Phenytoin and cognitive function: effects on normal volunteers and implications for epilepsy. ( Huppert, FA; Thompson, P; Trimble, M, 1981) |
| "To determine the influence of phenytoin (PHT) monotherapy on the serum levels of homocysteine (Hcy), folate and vitamin B12 in patients with epilepsy." | 9.01 | Effects of phenytoin on serum levels of homocysteine, vitamin B12, folate in patients with epilepsy: A systematic review and meta-analysis (PRISMA-compliant article). ( Chen, S; Xia, Z; Xu, H; Xu, S; Xu, Y; Zhang, N, 2019) |
| "To review the time to treatment failure, remission and first seizure with carbamazepine compared with phenytoin when used as monotherapy in people with focal onset seizures (simple or complex focal and secondarily generalised), or generalised onset tonic-clonic seizures (with or without other generalised seizure types)." | 9.01 | Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review. ( Marson, AG; Nevitt, SJ; Tudur Smith, C, 2019) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are fatal adverse cutaneous drug reactions which may be induced by phenytoin (PHT) or lamotrigine (LTG)." | 8.91 | HLA-B*1502 increases the risk of phenytoin or lamotrigine induced Stevens-Johnson Syndrome/toxic epidermal necrolysis: evidence from a meta-analysis of nine case-control studies. ( Huo, J; Li, X; Mei, S; Wang, J; Yu, K; Zhao, Z; Zhu, Y, 2015) |
| "Small sample size, poor methodological quality and lack of data on important outcome measures prevent any meaningful conclusions regarding the efficacy and safety of sulthiame as monotherapy in epilepsy." | 8.90 | Sulthiame monotherapy for epilepsy. ( Marson, AG; Milburn-McNulty, P; Powell, G; Sills, GJ, 2014) |
| "To review the best evidence comparing oxcarbazepine and phenytoin when used as monotherapy in patients with epilepsy." | 8.83 | Oxcarbazepine versus phenytoin monotherapy for epilepsy. ( Marson, AG; Muller, M; Williamson, PR, 2006) |
| "Side effects of certain drugs such as cyclosporin A (CsA) and phenytoin may induce gingival overgrowth which in some instances become unacceptable to the patient because esthetic, functional, and other effects." | 8.80 | Reduction of severe gingival overgrowth in a kidney transplant patient by replacing cyclosporin A with tacrolimus. ( Arriba, L; de Andrés, A; Hernández, G; Lucas, M, 2000) |
| " In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i." | 8.02 | Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021) |
| "There was higher frequency of breakthrough seizures during immediate-release phenytoin capsule usage than during extended-release phenytoin capsule usage by epilepsy patients." | 7.96 | Budget Impact Analysis of Extended-Release Phenytoin Capsules Compared With Immediate-Release Phenytoin Capsules for Patients With Epilepsy in Thailand. ( Suthipinijtham, P; Tiamkao, S, 2020) |
| "To examine the influence of obesity and sex on phenytoin LDs." | 7.91 | Evaluation of Intravenous Phenytoin and Fosphenytoin Loading Doses: Influence of Obesity and Sex. ( Alaniz, C; Burghardt, D; DasGupta, R, 2019) |
| "Cerebellar ataxia is present in 40% of patients with epilepsy and chronic exposure to phenytoin." | 7.88 | Phenytoin-related ataxia in patients with epilepsy: clinical and radiological characteristics. ( Aeschlimann, DP; Aeschlimann, PC; Dennis, GJ; Grünewald, RA; Hadjivassiliou, M; Hoggard, N; Howell, SJ; Reuber, M; Shanmugarajah, PD, 2018) |
| "The goal of our study was to investigate the incidence of Stevens-Johnson syndrome (SJS), the frequency of SJS diagnosis, and the association between SJS and prior use of allopurinol, carbamazepine or phenytoin." | 7.88 | Incidence of Stevens-Johnson syndrome following combination drug use of allopurinol, carbamazepine and phenytoin in Taiwan: A case-control study. ( Cheng, CY; Cheng, FJ; Chuang, PC; Huang, YS; Pan, HY; Syu, FK, 2018) |
| " Phenytoin induced dystonia." | 7.88 | Phenytoin induced dystonia. ( Acar, T; Alkan, G; Çaksen, H; Cander, B; Ergin, M; Ertekin, B; Koçak, S, 2018) |
| "Phenytoin (PHE) and carbamazepine (CBZ) are first rank causative drugs that can induce drug rash with eosinophilia and systemic symptoms (DRESS) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)." | 7.88 | Evaluation of a lymphocyte transformation test and cytokine detection assay to identify phenytoin and carbamazepine provoked DRESS or SJS/TEN in epilepsy patients. ( Kumkamthornkul, P; Srinoulprasert, Y; Tansit, T; Tuchinda, P; Udnaen, S, 2018) |
| " He had been administered phenytoin and gabapentin for the treatment of symptomatic traumatic epilepsy 8 years before." | 7.88 | Hypothyroidism induced by phenytoin and gabapentin: A Case Report. ( Ishii, K; Miyake, Z; Tamaoka, A, 2018) |
| "We selected and screened for mutations a group of 24 epileptic patients who experienced significant gingival overgrowth following phenytoin therapy." | 7.85 | Lack of pathogenic mutations in SOS1 gene in phenytoin-induced gingival overgrowth patients. ( Consoli, F; De Luca, A; Di Bonaventura, C; Giallonardo, AT; Guida, V; Margiotti, K; Pascolini, G; Pizzuti, A, 2017) |
| "Recent adverse event reports have raised the question of increased angioedema risk associated with exposure to levetiracetam." | 7.85 | Risk of angioedema associated with levetiracetam compared with phenytoin: Findings of the observational health data sciences and informatics research network. ( Banda, JM; Duke, JD; Hripcsak, G; Jin, P; Khoma, Y; Reich, C; Ryan, PB; Schuemie, MJ; Schwalm, MS; Shah, NH; Suchard, MA; Wu, Y; Xu, H, 2017) |
| "The PPK model, using the power scaling of body weight, effectively elucidated the topiramate serum concentration profile ranging from pediatric to adult patients." | 7.85 | Population Pharmacokinetics of Topiramate in Japanese Pediatric and Adult Patients With Epilepsy Using Routinely Monitored Data. ( Ikeda, A; Ito, S; Matsubara, K; Sugimoto, M; Takeuchi, M; Yamamoto, S; Yano, I; Yonezawa, A, 2017) |
| "We aimed to explore the possible influence of CYP2C9 (*2, *3 and IVS8-109 A>T), CYP2C19 (*2, *3 and *17) and ABCB1 (1236C>T, 2677G>A/T and 3435C>T) on phenytoin (PHT) plasma concentrations in 64 Mexican Mestizo (MM) patients with epilepsy currently treated with PHT in mono- (n=25) and polytherapy (n=39)." | 7.83 | CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy. ( Dorado, P; Familiar-López, I; Fricke-Galindo, I; Jung-Cook, H; LLerena, A; López-López, M; Martínez-Juárez, IE; Monroy-Jaramillo, N; Ortega-Vázquez, A; Peñas-Lledó, E, 2016) |
| "To identify the factors influencing topiramate pharmacokinetics (PK) in a large population of adult patients with epilepsy using population PK analysis." | 7.83 | Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis. ( Bae, EK; Jang, IJ; Kim, TJ; Lee, J; Lee, KJ; Lee, SK; Moon, J; Shin, D; Shin, JW; Shin, YW, 2016) |
| "Although it has been reported that some antiepileptic drugs have inducing or inhibiting effects on lamotrigine (LTG) clearance, whether they have the same effects in Asian epilepsy patients as in those in other countries has not been clarified, especially in children." | 7.83 | The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy. ( Abe, S; Azuma, Y; Ishihara, N; Ito, Y; Itomi, K; Kidokoro, H; Kojima, S; Kurahashi, H; Kurahashi, N; Maruyama, K; Natsume, J; Negoro, T; Okumura, A; Suzuki, M; Takeuchi, T; Tsuji, T; Watanabe, K; Yamada, K; Yamamoto, H, 2016) |
| "Lamotrigine (LTG) is a widely used antiepileptic-drug (AED) for the treatment of epilepsy." | 7.81 | Effect of comedication on lamotrigine clearance in Korean epilepsy patients. ( Hong, SB; Joo, EY; Kim, HJ; Kim, TE; Lee, SY; Seo, DW, 2015) |
| "To examine the effects of cytochrome P450 3A4 (CYP3A4), cytochrome P450 3A5 (CYP3A5) and ATP-binding cassette sub-family B member 1 (ABCB1) genetic polymorphisms on carbamazepine (CBZ) plasma concentrations in Chinese patients with epilepsy using CBZ as monotherapy and bitherapy with phenytoin (PHT), phenobarbital (PB), or valproic acid (VPA)." | 7.81 | Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy. ( Liu, DQ; Ma, HY; Sheng, YH; Wang, C; Wang, P; Yin, T; Zhou, BT, 2015) |
| "Valproic acid (VPA), which is widely used to treat epilepsy, migraine, and bipolar disorder, can causes severe hyperammonemia." | 7.81 | Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy. ( Hirai, K; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y, 2015) |
| "A 12-year-old patient with refractory epilepsy syndrome presented with phenytoin toxicity, following a concomitant treatment with phenytoin, valproic acid, and lamotrigine." | 7.80 | Drug interaction between phenytoin and valproic acid in a child with refractory epilepsy: a case report. ( Carnevale, RC; Carvalho, IV; de Fátima Lopes Ambrósio, R; de Queiroz, RA; dos Reis, MC; Mazzola, PG; Moriel, P; Visacri, MB, 2014) |
| "Lacosamide (LCM), a new antiepileptic drug (AED) approved as adjunctive therapy for the treatment of patients with partial-onset seizures, has limited pharmacokinetic and drug interaction data." | 7.80 | Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs. ( Duncan, JS; Markoula, S; Patsalos, PN; Ratnaraj, N; Sander, JW; Teotonio, R, 2014) |
| "Valproic acid, which is widely used to treat various types of epilepsy, may cause severe hyperammonemia." | 7.80 | 4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. ( Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Miyakawa, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R, 2014) |
| " Pentylenetetrazole (PTZ)-kindled and spontaneous model of epilepsy (EL) mice were used as models of chemically induced and spontaneous epilepsy, respectively." | 7.80 | Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models. ( Ohtsuki, S; Terasaki, T; Uchida, Y, 2014) |
| "To facilitate therapeutic monitoring of antiepileptic drugs (AEDs) by healthcare professionals for patients with epilepsy (PWE), we applied a GC-MS assay to measure three AEDs: carbamazepine (CBZ), phenytoin (PHT) and valproic acid (VPA) levels concurrently in one dried blood spot (DBS), and validated the DBS-measured levels to their plasma levels." | 7.80 | Clinical validation and implications of dried blood spot sampling of carbamazepine, valproic acid and phenytoin in patients with epilepsy. ( Ho, PC; Kong, ST; Kumar, PK; Lee, WB; Lim, SH; Ng, YL; Wang, HY; Wong, PS, 2014) |
| " Adults with a history of epilepsy who used a generic phenytoin and whose therapy was switched to another generic phenytoin between January 2012 and June 2013 were included (n = 80)." | 7.80 | Switching between phenytoin generics in patients with epilepsy may lead to increased risk of breakthrough seizure: chart analysis and practice recommendations. ( Chu, K; Jung, KH; Lee, SK; Lee, ST; Moon, J; Shin, JW, 2014) |
| "Cognitive impairment implicates many factors beyond phenytoin monotherapy in patients with epilepsy." | 7.79 | Association of apolipoprotein E ε4 allele with cognitive impairment in patients with epilepsy and interaction with phenytoin monotherapy. ( Ganesvaran, RA; Narmadha, MP; Palanisamy, A; Rajendran, NN, 2013) |
| "We recruited ambulatory young adults with epilepsy who were taking phenytoin." | 7.79 | The association between BsmI polymorphism and bone mineral density in young patients with epilepsy who are taking phenytoin. ( Geater, A; Leelawattana, R; Limapichart, K; Phabphal, K; Sathirapanya, P; Setthawatcharawanich, S; Thammakumpee, N; Witeerungrot, N, 2013) |
| "Phenytoin is known to be able to induce cerebellar atrophy in patients with epilepsy." | 7.79 | The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy. ( Borgio, JG; De Paola, L; Scola, RH; Silvado, C; Twardowschy, CA; Werneck, LC, 2013) |
| " The distribution of variant CYP2C9 alleles and prevalence of phenytoin adverse reactions were hereby investigated in a population of patients diagnosed with epilepsy." | 7.77 | CYP2C9 polymorphism in patients with epilepsy: genotypic frequency analyzes and phenytoin adverse reactions correlation. ( De Paola, L; Scola, RH; Silvado, CE; Twardowschy, CA; Werneck, LC, 2011) |
| " She was receiving phenytoin for epilepsy for 2 years." | 7.76 | Phenytoin induced vitamin D deficiency presenting as proximal muscle weakness. ( Aggarwal, A; Faridi, MM, 2010) |
| "Phenytoin, one of the most common antiepileptic drugs, is a major cause of antiepileptic drug hypersensitivity syndrome (AHS), which is a rare but potentially fatal complication." | 7.75 | Agranulocytosis following phenytoin-induced hypersensitivity syndrome. ( Imai, K; Ito, S; Oguni, H; Osawa, M; Sasaki, K; Shioda, M, 2009) |
| "To determine the utility and tolerability of levetiracetam (LEV) compared to phenytoin (PHT) in preventing clinical seizures in patients with subarachnoid hemorrhage (SAH)." | 7.75 | Utility of levetiracetam in patients with subarachnoid hemorrhage. ( Husain, AM; Shah, D, 2009) |
| "Phenytoin (PHT) is widely used to treat epilepsy in elderly patients, but information on its pharmacokinetics in this population is limited." | 7.74 | Phenytoin half-life and clearance during maintenance therapy in adults and elderly patients with epilepsy. ( Ahn, JE; Birnbaum, AK; Brundage, RC; Cloyd, JC; Conway, JM; Leppik, IE; Marino, SE; Musib, LC; Ramsay, RE; Rarick, JO; White, JR, 2008) |
| "Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) in Han Chinese, but not in Caucasian populations." | 7.74 | Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. ( Desudchit, T; Hirankarn, N; Kangwanshiratada, O; Korkij, W; Limotai, C; Locharernkul, C; Loplumlert, J; Shotelersuk, V; Suphapeetiporn, K; Tongkobpetch, S, 2008) |
| "Ecto-nucleotidases, one of the main mechanisms involved in the control of adenosine levels in the synaptic cleft, have shown increased activities after the pilocarpine model of epilepsy." | 7.74 | Antiepileptic drugs prevent changes induced by pilocarpine model of epilepsy in brain ecto-nucleotidases. ( Bogo, MR; Bonan, CD; Bruno, AN; Cognato, Gde P; da Silva, RS; Sarkis, JJ, 2007) |
| "To compare the temporal pattern of seizures after acute withdrawal of oxcarbazepine (OXC) and phenytoin (PHT) in the epilepsy monitoring unit (EMU)." | 7.74 | Temporal pattern of oxcarbazepine and phenytoin withdrawal seizures during epilepsy monitoring. ( Abou-Khalil, BW; Azar, NJ; Song, Y; Wang, L, 2008) |
| "This is the first report demonstrating an association between the SCN1A polymorphism and carbamazepine-resistant epilepsy." | 7.74 | Association between SCN1A polymorphism and carbamazepine-resistant epilepsy. ( Abe, T; Hori, M; Ishitsu, T; Nakagawa, K; Nakagawa, T; Seo, T, 2008) |
| " The purpose of this study was to investigate the afferent fiber system to the cerebellum in patients with phenytoin (PHT)-induced cerebellar atrophy in comparison with cerebellar atrophy of other etiologies by using DT-MRI." | 7.72 | Diffusion tensor MRI and fiber tractography of cerebellar atrophy in phenytoin users. ( Chu, M; Heo, K; Kim, DI; Kim, DJ; Kim, SY; Lee, BI; Lee, SK; Mori, S, 2003) |
| "Phenytoin-induced gingival overgrowth is a well-known and frequently reported gingival lesion, which was first detected in 1939." | 7.72 | Phenytoin-induced gingival overgrowth in un-cooperated epilepsy patients. ( Cakmak, H; Gursoy, UK; Marakoglu, I; Marakoglu, K, 2004) |
| "The effects of phenytoin (PHT) and phenobarbital (PHB) on EEG activity and behavior was studied in the model of epilepsy induced by intracerebroventricular (i." | 7.72 | The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats. ( Stanojlovic, O; Stojanovic, J; Susic, V; Zivanovic, D, 2004) |
| "To search for the optimal dosage of phenytoin in patients with epilepsy based on the metabolic activities of CYP2C9 and CYP2C19 polymorphisms, a total of 169 patients receiving phenytoin treatment for more than 1 month were recruited." | 7.72 | Dosage recommendation of phenytoin for patients with epilepsy with different CYP2C9/CYP2C19 polymorphisms. ( Chang, CJ; Chen, CC; Hung, CC; Lin, CJ; Liou, HH, 2004) |
| " The boy was exposed to phenytoin, in combination with carbamazepine, during pregnancy." | 7.71 | Chondrodysplasia punctata (CDP) with features of the tibia-metacarpal type and maternal phenytoin treatment during pregnancy. ( Annerén, G; Brandberg, G; Larsson, M; Lönnerholm, T; Wester, U, 2002) |
| "We report the case of a 24-y-old woman who presented with repeated episodes of otitis due to panhypogammaglobulinemia and low levels of mature CD19 + B cells (84 cells/microl) associated with phenytoin treatment." | 7.71 | Reversible panhypogammaglobulinemia associated with phenytoin treatment. ( Pereira, LF; Sanchez, JF, 2002) |
| "To determine the effects of temperature on binding characteristics of phenytoin to serum proteins in paediatric patients with epilepsy." | 7.71 | Effect of temperature on serum protein binding characteristics of phenytoin in monotherapy paediatric patients with epilepsy. ( Itokazu, N; Kanemaru, R; Kodama, H; Kodama, Y; Shinozawa, S; Sugimoto, T, 2001) |
| "To elucidate the involvement of bFGF (basic fibroblast growth factor) in the pathogenesis of phenytoin-induced gingival overgrowth, we measured the concentration of bFGF in the serum of 36 epileptic patients taking phenytoin and in 94 normal volunteers by enzyme-linked immunosorbent assay technique." | 7.70 | Increased bFGF level in the serum of patients with phenytoin-induced gingival overgrowth. ( Maita, E; Sasaki, T, 1998) |
| "The last premortem serum concentrations of phenobarbital (PB), phenytoin (PHT), carbamazepine (CBZ) and its CBZ-10,11-epoxide metabolite (CE) were compared with the corresponding postmortem serum concentrations in 16 adult patients of an epilepsy centre." | 7.70 | Comparison between premortem and postmortem serum concentrations of phenobarbital, phenytoin, carbamazepine and its 10,11-epoxide metabolite in institutionalized patients with epilepsy. ( Jürgens, U; May, T; Rambeck, B; Schnabel, R, 1999) |
| "A 30-year-old man was given high doses of phenytoin together with 4 antituberculous drugs for a seizure associated with a probable brain tuberculoma." | 7.70 | [Residual cerebellar ataxia following acute phenytoin intoxication]. ( al Beladi, K; al Jumah, M; Amene, P; Awada, A, 1999) |
| "The effects of temperature on the binding kinetics of phenytoin (PHT) to serum proteins were determined in patients with epilepsy." | 7.70 | Temperature effect on serum protein binding kinetics of phenytoin in monotherapy patients with epilepsy. ( Kanemaru, R; Kodama, H; Kodama, Y; Mitsuyama, Y; Shinozawa, S; Todaka, K, 1999) |
| "The potential effect of co-medication with phenobarbitone, primidone and carbamazepine on plasma and saliva concentrations of 5-(4-hydroxyphenyl)-5-phenylhydantoin (4-HPPH), the major metabolite of phenytoin in man and on the incidence of phenytoin-induced gingival overgrowth was investigated in a group of 36 adult epileptic patients." | 7.70 | The effect of multiple anticonvulsant therapy on the expression of phenytoin-induced gingival overgrowth. ( Ball, DE; Kamali, F; McLaughlin, WS; Seymour, RA, 1999) |
| "The chronic treatment with phenytoin or the acute intoxication by this drug may cause permanent cerebellar injury with atrophy of cerebellum vermis and hemispheres, which can be detected by neuroimaging studies." | 7.70 | [Dose-dependent relationship of chronic use of phenytoin and cerebellar atrophy in patients with epilepsy]. ( Cendes, F; Dantas, CD; Del Negro, A; Montenegro, MA; Zanardi, V, 2000) |
| "The aim of the present study was to determine the gender-related binding characteristics of phenytoin (PHT) to serum proteins in adult patients with epilepsy." | 7.70 | No gender effect on binding characteristics of phenytoin to serum proteins in monotherapy for adult patients with epilepsy. ( Kanemaru, R; Kodama, H; Kodama, Y; Mitsuyama, Y; Shinozawa, S; Todaka, K, 2000) |
| "We evaluated the effects of carbamazepine (CBZ) on serum androgen levels and sexual function prospectively for 5 years in 11 men with epilepsy and in 25 patients receiving either CBZ (14 patients) or phenytoin (PHT) (11) monotherapy for > 5 years." | 7.69 | Carbamazepine, phenytoin, sex hormones, and sexual function in men with epilepsy. ( Isojärvi, JI; Lukkarinen, O; Myllylä, VV; Pakarinen, AJ; Repo, M, 1995) |
| "Urinary excretions of carbamazepine, carbamazepine-10,11-epoxide, carbamazepine-10,11-trans-diol, 9-hydroxyacridan and 2- and 3-hydroxycarbamazepine were measured at various stages of pregnancy, and in the post-natal period, in ten epileptic women, six of whom took no other enzyme-inducing anticonvulsant and four of whom took such co-medication." | 7.69 | Metabolism of carbamazepine and co-administered anticonvulsants during pregnancy. ( Bernus, I; Dickinson, RG; Eadie, MJ; Hooper, WD, 1995) |
| "Cerebellar atrophy has been noted in patients with phenytoin exposure." | 7.69 | Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy. ( Barr, WB; Lantos, G; Ney, GC; Schaul, N, 1994) |
| "Phenytoin serum concentrations were evaluated in 88 epileptic women at different stages of pregnancy and 40 women during postnatal periods." | 7.69 | Phenytoin serum concentration monitoring during pregnancy and puerperium in Mexican epileptic women. ( Amancio-Chassin, O; Belmont-Gómez, A; Estrada-Altamirano, A; Hernández-Serrano, M; Herrerías-Cunedo, T; Rodríguez-Palomares, C, 1995) |
| "Topiramate, a structurally novel anticonvulsant, and phenytoin were evaluated in a rat model of ischemia-induced epilepsy." | 7.69 | Anticonvulsant activity of topiramate and phenytoin in a rat model of ischemia-induced epilepsy. ( Edmonds, HL; Jiang, YD; Shank, RP; Zhang, PY, 1996) |
| "The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36." | 7.69 | Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996) |
| "We examined the effect of CYP2C9/19 polymorphisms on the pharmacokinetics of phenytoin in 17 Japanese patients with epilepsy." | 7.69 | Effect of CYP2C polymorphisms on the pharmacokinetics of phenytoin in Japanese patients with epilepsy. ( Furusho, K; Hashimoto, Y; Hattori, H; Iui, K; Odani, A; Otsuki, Y; Takano, M, 1996) |
| "Twelve patients with epilepsy receiving chronic phenytoin therapy and 12 healthy control subjects matched for age and gender received a single oral dose of nisoldipine (40 and 20 mg, respectively)." | 7.69 | Reduced plasma nisoldipine concentrations in phenytoin-treated patients with epilepsy. ( Cipolla, G; Gatti, G; Heinig, R; Michelucci, R; Ochan, M; Passarelli, D; Perucca, E; Tassinari, CA, 1996) |
| "We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy." | 7.69 | BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. ( Morimoto, K; Sato, H; Sato, K; Sato, S; Yamada, N, 1997) |
| "Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline." | 7.68 | Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993) |
| "The steady-state 72 h urinary excretion of various phenytoin metabolites has been measured in 10 epileptic women, whose plasma phenytoin concentrations relative to the phenytoin dose fell during pregnancy and rose again post-partum." | 7.68 | Phenytoin metabolism during pregnancy. ( Dickinson, RG; Eadie, MJ; Hooper, WD; Lander, CM; McKinnon, GE, 1992) |
| "We retrospectively collected plasma level assessments performed in 96 adult patients with epilepsy on stable monotherapy, including 9 patients on clobazam (CLB), 34 on carbamazepine (CBZ), 24 on phenobarbital (PB), 9 on phenytoin (PHT), and 20 on valproate (VPA); these results were compared to those obtained in 54 adult patients on stable bitherapy with the association of CLB with either CBZ (n = 17), PB (n = 17), PHT (n = 5), or VPA (n = 15)." | 7.68 | Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy. ( Bonneton, J; Dravet, C; Genton, P; Mesdjian, E; Roger, J; Sennoune, S, 1992) |
| "We report the cases of four patients who were taking the anticonvulsant drugs phenytoin or carbamazepine and in whom skin lesions developed that showed histologic features suggestive of mycosis fungoides." | 7.68 | Mycosis fungoides-like lesions associated with phenytoin and carbamazepine therapy. ( Kruyswijk, MR; Meijer, CJ; Rijlaarsdam, U; Scheffer, E; Willemze, R, 1991) |
| "Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug." | 7.67 | Bioavailability and pharmacokinetics of phenytoin during pregnancy. ( Chalk, JB; de Wytt, C; Eadie, MJ; Lander, CM; Livingstone, I; Smith, MT; Symoniw, P, 1984) |
| "To assess the most efficient means of monitoring thyroid status in an epilepsy clinic, total thyroxine (T4), free thyroxine stimulating hormone (TSH) were measured in 71 adult patients treated long-term with either phenytoin (DPH), carbamazepine (CBZ) or sodium valproate (VAL)." | 7.67 | The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic. ( Borsey, DQ; Browning, MC; Connacher, AA; Davidson, DL; Jung, RT, 1987) |
| "We report the occurrence of bilateral cataracts in a young adult which developed shortly after documented high serum levels of phenytoin." | 7.67 | Development of presenile cataracts in association with high serum levels of phenytoin. ( Earll, J; Kattan, H; Lemp, M; Mathers, W, 1987) |
| "Report on a prospective longitudinal study of alterations in polygraphic sleep by phenytoin monotherapy for epilepsy." | 7.67 | Response of polygraphic sleep to phenytoin treatment for epilepsy. A longitudinal study of immediate, short- and long-term effects. ( Noachtar, S; Röder-Wanner, UU; Wolf, P, 1987) |
| "Reversible chronic cerebellar ataxia followed phenytoin treatment in two epileptic women." | 7.67 | Reversible chronic cerebellar ataxia after phenytoin intoxication: possible role of cerebellum in cognitive thought. ( Attig, E; Botez, MI; Gravel, J; Vézina, JL, 1985) |
| "Among 50 patients with phenytoin intoxication, 14 had seizures during the episode." | 7.67 | Incidence of seizures with phenytoin toxicity. ( Masdeu, JC; Stilman, N, 1985) |
| "Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered." | 7.66 | Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports. ( Arena, R; Bindi, A; Bonuccelli, U; De Scisciolo, G; Marcacci, G; Rossi, L, 1983) |
| "The problem of phenytoin-induced gingival hyperplasia is dicussed within the context of consultative planning between oral care practitioners and the physician managing the epilepsy." | 7.66 | Therapeutic alternatives in phenytoin-induced gingival hyperplasia. A case report and discussion. ( Kirkham, DB; Reynolds, NC, 1980) |
| "Sodium valproate is often used with phenytoin when epilepsy cannot be controlled by a single drug." | 7.66 | Phenytoin-valproate interaction: importance of saliva monitoring in epilepsy. ( Hamshaw-Thomas, A; Knott, C; Reynolds, F, 1982) |
| "The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)." | 7.66 | Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982) |
| "Cataracts developed in two young adults who were receiving prolonged antiepileptic treatment with phenobarbital sodium and phenytoin sodium." | 7.66 | Presenile cataracts in phenytoin-treated epileptic patients. ( Bar, S; Feller, N; Savir, H, 1983) |
| "Analysis of plasma phenytoin in a group of patients treated for epilepsy showed that only 36% had values in the therapeutic range." | 7.66 | Prediction of phenytoin dosage in epilepsy using multiple linear regression. ( Gray, SP, 1982) |
| " Using accepted CT criteria for the diagnosis of cerebellar atrophy, the films were analyzed in a blind, unbiased fashion to evaluate possible relationship between cerebellar atrophy and phenytoin use or epilepsy itself." | 7.66 | Cerebellar atrophy in epilepsy and headache: lack of relationship to phenytoin. ( Ballenger, CE; Brooks, BS; El Gammal, T; Green, JB; King, DW; Lucke, JF, 1982) |
| "1 Patients with poorly controlled epilepsy were cautiously transferred from multiple drug therapy to treatment with phenytoin sodium alone." | 7.66 | Serum phenytoin concentration and clinical response in patients with epilepsy. ( Gannaway, DJ; Mawer, GE, 1981) |
| "We describe a procedure for determining 2-ethyl-2-phenylmalonamide (I) in serum of epilepsy patients dosed with primidone (II) for seizure control, by extracting the sample with chloroform under basic conditions, with use of an internal standard, 2-ethyl-2-(p-tolyl)malonamide, and without derivative formation." | 7.66 | Monitoring 2-ethyl-2-phenylmalonamide in serum by gas-liquid chromatography: application to retrospective study in epilepsy patients dosed with primidone. ( Haidukewych, D; Rodin, EA, 1980) |
| "Nine cases of childhood epilepsy manifesting motor convulsions uncontrolled despite high levels of phenytoin (PHT) were studied clinically and electroencephalographically." | 7.66 | Childhood epilepsy uncontrolled by phenytoin: clinical and electroencephalographic study. ( Iinuma, K; Onuma, A; Tada, K; Takamatsu, N, 1979) |
| "Blood levels of phenytoin, total thyroxine, and free thyroxine were determined in 10 epileptic women during and following pregnancy." | 7.66 | Epilepsy and pregnancy. Serum thyroxine levels during phenytoin therapy. ( Ramsay, RE; Spellacy, WN; Strauss, RG; Wilder, BJ; Willmore, LJ, 1979) |
| "The effect of long-term phenytoin therapy on serum triglyceride and cholesterol levels in 20 patients with epilepsy was investigated." | 7.66 | Changes in serum triglyceride and cholesterol levels during long-term phenytoin treatment for epilepsy. ( Luoma, PV; Reunanen, MI; Sotaniemi, EA, 1979) |
| "Malignant mesenchymoma developed in an 18-year-old patient with phenytoin-associated cleft lip and palate." | 7.65 | Malignant mesenchymoma and birth defects. Prenatal exposure to phenytoin. ( Blattner, WA; Fraumeni, JF; Henson, DE; Young, RC, 1977) |
| "Cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and probenecid were examined in 14 children with epilepsy (ages 6 months to 17 years) and 17 controls (ages 14 months to 16 years)." | 7.65 | Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. ( Bowers, MB; Cohen, DJ; Shaywitz, BA, 1975) |
| "In vitro and in vivo immunologic studies were performed on a 28-year-old woman with phenytoin sodium-induced pseudolymphoma syndrome." | 7.65 | Phenytoin-induced pseudolymphoma syndrome: an immunologic study. ( Charlesworth, EN, 1977) |
| "Severe osteomalacia was present in two epileptic patients who were under long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide." | 7.65 | Acetazolamide-accelerated anticonvulsant osteomalacia. ( Mallette, LE, 1977) |
| "The relationship among the serum concentration of phenytoin, pneumoencephalographic measurements describing, in particular, cerebellar atrophy, and various other clinical variables was analyzed statistically in a series of 131 phenytoin-treated mentally retarded epileptics." | 7.65 | Cerebellar atrophy in phenytoin-treated mentally retarded epileptics. ( Helle, EP; Iivanainen, M; Viukari, M, 1977) |
| " Thirteen ambulant patients suffering from partial epilepsy with complex symptomatology, who were already being treated with phenytoin in optimal doses (plasma level 14-20 mug/ml) were also given carbamazepine." | 7.65 | Plasma levels of carbamazepine and carbamazepine-10,11-epoxide during treatment of epilepsy. ( Bertilsson, L; Eichelbaum, M; Lund, L; Palmér, L; Sjöqvist, F, 1976) |
| "Lamotrigine is an effective add-on therapy against a range of epileptic seizure types." | 6.69 | Lamotrigine monotherapy in newly diagnosed untreated epilepsy: a double-blind comparison with phenytoin. ( Abbott, R; Dellaportas, CI; Findley, LJ; Gibberd, FB; Gross, M; Park, DM; Perkin, GD; Steiner, TJ, 1999) |
| "Fosphenytoin was as well tolerated as intramuscular placebo at the injection site." | 6.68 | Safety and tolerance of multiple doses of intramuscular fosphenytoin substituted for oral phenytoin in epilepsy or neurosurgery. ( Campbell, K; Garnett, WR; Henkin, SA; Kugler, AR; Pellock, JM; Ramsay, RE; Wilder, BJ, 1996) |
| "The population pharmacokinetic parameters of phenytoin were estimated using routine therapeutic drug monitoring data from 116 epileptic patients." | 6.68 | Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: analysis with a dose-dependent clearance model. ( Furusho, K; Hashimoto, Y; Hattori, H; Inui, K; Koue, T; Odani, A; Otsuki, Y; Takano, M; Takayanagi, K; Yasuhara, M, 1996) |
| "1." | 6.66 | A multicentre study of vigabatrin for drug-resistant epilepsy. ( Ben-Menachem, E; Browne, TR; Mattson, RH; Miketta, RM; Penry, JK; Sherry, KM; Smith, DB; Szabo, GK; Treiman, DM; Wilder, BJ, 1989) |
| "Phenytoin has been widely prescribed alone; our results indicate that sodium valproate may also be used as a single drug in the treatment of several types of epilepsy." | 6.65 | Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy. ( Johnson, RH; Lambie, DG; Melville, ID; Nanda, RN; Shakir, RA, 1981) |
| "Phenytoin has been explored in over 100 different disorders; the last two promising indications tested in the clinic are breast cancer and optic neuritis." | 6.55 | Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action. ( Keppel Hesselink, JM; Kopsky, DJ, 2017) |
| "Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin." | 6.47 | Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011) |
| " The long-term use of phenytoin is not recommended for patients with loss of locomotion, marked cognitive impairment, or symptoms and signs of cerebellar disease." | 6.40 | Phenytoin: effective but insidious therapy for epilepsy in people with intellectual disability. ( Iivanainen, M, 1998) |
| "Plasma concentrations of lamotrigine, an antiepileptic drug obtained in three adult controlled clinical trials conducted in the United States were pooled and analyzed using NONMEM, a population pharmacokinetic computer program, to facilitate development of dosing guidelines." | 6.40 | Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy. ( Chen, C; Cox, E; Fiedler-Kelly, J; Grasela, TH; Risner, ME; Womble, GP, 1999) |
| "Valproic acid has become a regular component of antiepileptic therapy." | 6.36 | [Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)]. ( Fröscher, W; Gugler, R; Schulz, HU, 1978) |
| "Phenytoin (PHT) is a first-line antiepileptic drug in clinics, which could decrease neuronal bioelectric activity by blocking the voltage-operated sodium channels." | 5.91 | Calcium Phosphate-Based Nanoformulation Selectively Abolishes Phenytoin Resistance in Epileptic Neurons for Ceasing Seizures. ( Cao, D; Guan, Q; Li, M; Luo, Z; Mao, X; Wang, X, 2023) |
| "Epilepsy is a chronic neurological disorder that is characterized by episodes of seizure." | 5.72 | Clinical Evaluation of Levetiracetam in the Treatment of Epilepsy. ( Guan, S; Liu, J; Qian, F; Wang, Y; Wu, H; Yang, J, 2022) |
| "Lacosamide is a novel anticonvulsant that acts by enhancing sodium channel slow inactivation." | 5.56 | Therapeutic Monitoring of Lacosamide in Japanese Patients With Epilepsy: Clinical Response, Tolerability, and Optimal Therapeutic Range. ( Araki, Y; Fukushima, Y; Imai, K; Kagawa, Y; Takahashi, Y; Terada, K; Yamamoto, Y, 2020) |
| "Phenytoin has been decreasingly used because of the high interindividual variability in drug concentration and the narrow therapeutic window." | 5.51 | Optimal Dosing Regimen of Phenytoin for Korean Epilepsy Patients: From Premature Babies to the Elderly. ( Chae, D; Guk, J; Kim, JH; Lee, SG; Park, K, 2019) |
| " Phenobarbital versus levetiracetam as first-line ASM in EEG-confirmed neonatal seizures (one trial) Phenobarbital is probably more effective than levetiracetam in achieving seizure control after first loading dose (RR 2." | 5.41 | Anti-seizure medications for neonates with seizures. ( Abiramalatha, T; Brigo, F; Hartmann, H; Pressler, R; Ramaswamy, VV; Thanigainathan, S, 2023) |
| "Tamoxifen is a prodrug, requiring cytochrome P450 enzyme-mediated metabolism to form the active metabolite endoxifen." | 5.40 | Profound reduction in the tamoxifen active metabolite endoxifen in a patient on phenytoin for epilepsy compared with a CYP2D6 genotype matched cohort. ( Gryn, SE; Kim, RB; Teft, WA, 2014) |
| " P-gp polymorphisms may also affect phenytoin efficacy by altering its bioavailability (F)." | 5.39 | Studies on pharmacokinetic mechanism of phenytoin resistance in refractory epilepsy. ( Huang, JD; Huang, YS; Lai, ML; Tien, YE, 2013) |
| " Nevertheless, although the association of these genes with PTH-induced adverse effects has been well-documented in adult populations, this is the first report examining the influence of these genetic polymorphisms on PTH plasma levels and toxicity in a pediatric patient." | 5.39 | Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms. ( Dorado, P; Llerena, A; López-Torres, E; Martínez-Antón, J; Peñas-Lledó, EM, 2013) |
| "We determined PHT bioavailability during steady-state therapy by 1) measurement of the two principal deconjugated PHT urinary metabolites, 5-(4-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) and 5-(3,4-dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin (DHD); and 2) direct determination of absolute bioavailability after simultaneous administration of an oral formulation and parenteral stable-labeled PHT (SL-PHT)." | 5.37 | Excretion of the principal urinary metabolites of phenytoin and absolute oral bioavailability determined by use of a stable isotope in patients with epilepsy. ( Aliwarga, T; Brundage, RC; Cloyd, JC; Goel, V; Leppik, IE; Marino, SE; Remmel, RP, 2011) |
| " The drug combination elevated the plasma level of PHT in a patient on chemotherapy with capecitabine for colorectal cancer." | 5.37 | [A case of toxicity caused by drug interaction between capecitabine and phenytoin in patient with colorectal cancer]. ( Fukui, E; Kawahara, K; Sakurai, M; Ueda, R; Yamada, R, 2011) |
| "Curcumin was co-administered with sub-therapeutic dose of valproate 60min before PTZ injection." | 5.37 | Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. ( Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH, 2011) |
| "Phenytoin is a widely used anti-seizure agent, and a good correlation is observed between its concentration in plasma and the clinical effect." | 5.36 | Determination of free and total levels of phenytoin in human plasma from patients with epilepsy by MEKC: an adequate alternative to HPLC. ( Chen, SH; Hsieh, YH; Liao, FF; Lin, PC, 2010) |
| " The mean plasma drug concentrations at different time points and the pharmacokinetic parameters before and after piperine administration were compared by Student's t-test." | 5.33 | Effect of piperine on the steady-state pharmacokinetics of phenytoin in patients with epilepsy. ( Hota, D; Kharbanda, P; Pandhi, P; Pattanaik, S; Prabhakar, S, 2006) |
| "Oxcarbazepine was generally well tolerated during monotherapy and adjunctive therapy; 2." | 5.32 | Spotlight on oxcarbazepine in epilepsy. ( Bang, LM; Goa, KL, 2004) |
| "Levetiracetam has recently been approved as an adjunctive medication for partial seizures and frequently will be added to phenytoin." | 5.31 | Absence of pharmacokinetic drug interaction of levetiracetam with phenytoin in patients with epilepsy determined by new technique. ( Baltes, E; Browne, TR; Jensen, CM; Josephs, E; Leppik, IE; Paz, J; Szabo, GK, 2000) |
| " In addition, a population pharmacokinetic analysis was performed." | 5.30 | The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics. ( Higuchi, S; Ieiri, I; Imai, J; Mamiya, K; Ninomiya, H; Otsubo, K; Shimamoto, J; Tashiro, N; Yamada, H; Yukawa, E, 1998) |
| " PB was also the most toxic drug, followed by CBZ and by PHT." | 5.30 | Anticonvulsant and neurotoxic effects of intracerebroventricular injection of phenytoin, phenobarbital and carbamazepine in an amygdala-kindling model of epilepsy in the rat. ( Alós, M; Barcia, JA; Belda, V; Rubio, P; Serralta, A, 1999) |
| "Phenytoin toxicity is an uncommon problem seen in clinical practice." | 5.30 | Paradoxical seizures in phenytoin toxicity. ( Chua, HC; Tan, CB; Tjia, H; Venketasubramanian, N, 1999) |
| "Pregnant women with epilepsy on one or more of the following AEDs: lamotrigine, carbamazepine, phenytoin or levetiracetam." | 5.27 | AntiEpileptic drug Monitoring in PREgnancy (EMPiRE): a double-blind randomised trial on effectiveness and acceptability of monitoring strategies. ( Bagary, M; Coleman, J; D'Amico, M; Denny, E; Dodds, J; Eldridge, S; Greenhill, L; Hard, K; Kelso, A; Khan, KS; Marlin, N; McCorry, D; Middleton, L; Moss, N; Newton, S; Pirie, A; Pullen, A; Rikunenko, R; Roberts, T; Rogozińska, E; Thangaratinam, S; Weckesser, A, 2018) |
| "Phenobarbital may cause hyperactivity, behavioral problems, sedation, and even dementia; these effects are dose related to some extent." | 5.27 | Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy. ( Iivanainen, M; Savolainen, H, 1983) |
| "Oxazepam was more than 93% bound to serum proteins, but the extent of binding was not significantly different between the two groups." | 5.27 | Oxazepam pharmacokinetics in patients with epilepsy treated long-term with phenytoin alone or in combination with phenobarbitone. ( Hawksworth, GM; Khir, AS; Petrie, JC; Scott, AK; Steele, WH, 1983) |
| "Phenytoin treatment prevented the occurrence of convulsive and EEG seizures; however, lipid peroxidation was unaffected (16." | 5.27 | Effect of phenytoin and corticosteroids on seizures and lipid peroxidation in experimental posttraumatic epilepsy. ( Triggs, WJ; Willmore, LJ, 1984) |
| " Further, for dogs given phenobarbital, there was a sixfold variation between dosage and achieved serum concentration, whereas dogs given primidone manifested even greater variability between dosage and serum concentration." | 5.27 | Serum concentrations and efficacy of phenytoin, phenobarbital, and primidone in canine epilepsy. ( Farnbach, GC, 1984) |
| " In 48% of the patients the drug dosage had to be increased to combat the increased seizure frequency." | 5.27 | Serum phenytoin during pregnancy, labor and puerperium. ( Bardy, AH; Hiilesmaa, VK; Teramo, KA, 1987) |
| " Reducing the dosage by 19 mg/kg (A to B) decreased VPA plasma levels by 6." | 5.26 | Monitoring free valproic acid in epilepsy patients medicated with coanticonvulsants. ( Haidukewych, D; Rodin, EA, 1982) |
| "Carbamazepine was given to 152 patients who were receiving multiple drug therapy for uncontrolled seizures." | 5.26 | Role of carbamazepine in reducing polypharmacy in epilepsy. ( Maheshwari, MC; Padmini, R, 1981) |
| " Within the therapeutic range, small increments in dosage resulted in large increments in plasma DPH levels, and in the postpartum period high levels of DPH were encountered if the dosage was not reduced." | 5.26 | Phenytoin metabolism in pregnancy. ( Emery, MG; Kochenour, NK; Sawchuk, RJ, 1980) |
| "Patients with chronic renal failure had low plasma total, but disproportionately high plasma free, drug concentrations indicating impaired protein binding." | 5.26 | Salivary phenytoin concentrations in epilepsy and in chronic renal failure. ( Jones, NF; Reynolds, F; Smith, SE; Ziroyanis, PN, 1976) |
| " Although phenytoin dosage remained relatively constant, plasma phenytoin concentrations during pregnancy were significantly lower than nonpregnant concentrations." | 5.26 | Hematologic effects of phenytoin therapy during pregnancy. ( Ramsay, RE; Strauss, RG; Wilder, BJ; Willmore, LJ, 1978) |
| " When clinically indicated the daily dosage rate was adjusted by 50 mg steps until a serum concentration of 10--20 mg/l was produced." | 5.26 | Individual variation in daily dosage requirements for phenytoin sodium in patients with epilepsy. ( Barot, MH; Grant, RH; Maheendran, KK; Mawer, GE; Woodcock, BG, 1978) |
| "Steady-state serum-phenytoin levels were measured in five patients whose phenytoin dosage was changed three or more times for therapeutic purposes." | 5.25 | Serum-phenytoin levels in management of epilepsy. ( Dunlop, A; Richens, A, 1975) |
| "Phenytoin produced a lower serum level than the same dose of its sodium salt." | 5.25 | Systematic determination of the serum phenytoin level as an aid in the management of children with epilepsy. ( Gamstorp, I; Lilienberg, G; Norell, E, 1975) |
| "This article will review the different therapeutic options for status, from early treatment at home to the different first-line (benzodiazepines), second-line (phenobarbital, valproic acid, phenytoin, levetiracetam and lacosamide) or third-line treatments, which include both pharmacological (anaesthetics, propofol, ketamine, lidocaine, topiramate, brivaracetam or perampanel) and non-pharmacological (ketogenic diet, immunomodulatory treatments or epilepsy surgery) therapies." | 5.22 | [Paediatric status epilepticus]. ( García-Peñas, JJ; González-Alguacil, E; Soto-Insuga, V, 2022) |
| " Three groups of patients were studied: (A) epileptic under phenytoin monotherapy (n = 31); (B) with bipolar disorder under valproic acid treatment (n = 28); (C) elderly (n = 41)." | 5.22 | Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia. ( Fagiolino, P; González, R; Guevara, N; Maldonado, C; Queijo, C; Vázquez, M, 2016) |
| "We sought to determine the effect of changing phenytoin therapy on bone mineral density (BMD) and 25-hydroxyvitamin D in patients with epilepsy." | 5.17 | Effect of switching hepatic enzyme-inducer antiepileptic drug to levetiracetam on bone mineral density, 25 hydroxyvitamin D, and parathyroid hormone in young adult patients with epilepsy. ( Geater, A; Leelawattana, R; Limapichat, K; Phabphal, K; Sathirapanya, P; Setthawatcharawanich, S, 2013) |
| "In this prospective, observational, assessor-masked, multicentre study, we enrolled pregnant women with epilepsy on antiepileptic drug monotherapy (carbamazepine, lamotrigine, phenytoin, or valproate) between October, 1999, and February, 2004, at 25 epilepsy centres in the UK and the USA." | 5.17 | Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study. ( Baker, GA; Bromley, RL; Browning, N; Clayton-Smith, J; Cohen, MJ; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2013) |
| "Carbamazepine clearance was not associated with body weight or any parameterization of body size nor was age or race or any marker of hepatic or renal function in community dwelling elderly patients." | 5.16 | Population pharmacokinetics of carbamazepine in elderly patients. ( Birnbaum, AK; Brundage, RC; Collins, JF; Macias, FM; Punyawudho, B; Ramsay, ER, 2012) |
| "To evaluate the safety and tolerability of treatment with levetiracetam and determine the trough levels of levetiracetam in patients with traumatic brain injury (TBI) who are at high risk for posttraumatic epilepsy (PTE)." | 5.16 | Results of phase 2 safety and feasibility study of treatment with levetiracetam for prevention of posttraumatic epilepsy. ( Atabaki, SM; He, J; Herr, D; Klein, P; Levine, Z; McCarter, R; Natale, J; Nogay, C; Pearl, PL; Sandoval, F; Soldin, SJ; Trzcinski, S; Tsuchida, T; van den Anker, J, 2012) |
| "Phenytoin was associated with more fever and worse outcomes after intracerebral hemorrhage." | 5.14 | Anticonvulsant use and outcomes after intracerebral hemorrhage. ( Batjer, HH; Garg, RK; Levasseur, K; Liebling, S; Macken, MP; Naidech, AM; Schuele, SU, 2009) |
| "To evaluate topiramate (TPM) and phenytoin (PHT) monotherapy following rapid oral initiation in new-onset epilepsy." | 5.14 | Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new-onset epilepsy: a randomized double-blind clinical trial. ( Faught, E; Hulihan, J; Krumholz, A; Mao, L; Naritoku, D; Privitera, M; Ramsay, E; Schwarzman, L; Wiegand, F, 2010) |
| "To evaluate the efficacy and tolerability of the treatment with valproic acid (VPA) in patients with status epilepticus (SE) or acute repetitive seizures (ARS) comparing it with phenytoin (PHT) treatment." | 5.13 | Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin. ( Dabby, R; Gilad, R; Izkovitz, N; Lampl, Y; Rapoport, A; Sadeh, M; Weller, B, 2008) |
| "To evaluate the response to albendazole treatment in patients who had SSECTL and new onset seizures treated with antiepileptic drugs (AED) in a prospective clinical trial." | 5.13 | Albendazole therapy for single small enhancing CT lesions (SSECTL) in the brain in epilepsy. ( Chattopadhyay, A; Khandelwal, N; Sawhney, IM; Thussu, A, 2008) |
| " This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy." | 5.12 | Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021) |
| "The role of folic acid (5mg/day) in combination with oral hygiene measures (group II) vis-a-vis oral hygiene measures alone (group I) in prevention of phenytoin-induced gingival overgrowth was investigated in a one-year follow-up study on sixty, 8-13-year-old epileptic children receiving phenytoin." | 5.11 | Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect. ( Chawla, HS; Gauba, K; Goyal, A; Prasad, VN; Singhi, P, 2004) |
| "This study was designed to measure the effect of the addition of zonisamide on phenytoin pharmacokinetics under steady-state conditions in patients with epilepsy." | 5.11 | Lack of a clinically significant effect of zonisamide on phenytoin steady-state pharmacokinetics in patients with epilepsy. ( Garnett, WR; Levy, RH; Pan, WJ; Ragueneau-Majlessi, I; Rosenfeld, W; Schmerler, M; Shah, J, 2004) |
| "Subjects were 85 men with localization-related epilepsy (25 on carbamazepine [CBZ], 25 on phenytoin [PHT], 25 on lamotrigine [LTG], and 10 untreated for at least 6 months [no AED]) and 25 controls." | 5.11 | Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy. ( Bromfield, EB; Drislane, FW; Dworetzky, BA; Farina, EL; Frye, CA; Herzog, AG; Pennell, PB; Schomer, DL, 2005) |
| "Remacemide hydrochloride is a low-affinity, non-competitive NMDA receptor channel blocker under investigation for the treatment of epilepsy." | 5.10 | Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 800 mg/day) in a B.I.D. regimen. ( Blume, WT; Guberman, A; Holdich, TA; Jones, MW; Lee, MA; Pillay, N; Veloso, F; Weaver, DF, 2002) |
| "Remacemide hydrochloride is a low-affinity, non-competitive N-methyl-D-aspartic acid (NMDA) receptor channel blocker, under investigation in epilepsy." | 5.10 | Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 1200 mg/day) in a Q.I.D. regimen. ( Betts, TA; Boddie, HG; Chadwick, DW; Crawford, PM; Holdich, TA; Lindstrom, P; Newman, PK; Soryal, I; Wroe, S, 2002) |
| "The authors assessed the effect of concomitant antiepileptic therapy on steady-state plasma concentrations of the new antiepileptic drug (AED) topiramate and the potential relation between topiramate plasma levels and side effects in a cohort of 116 patients with epilepsy." | 5.10 | Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs. ( Albani, F; Avoni, P; Baruzzi, A; Contin, M; Riva, R, 2002) |
| "To determine whether biological maturation influences the kinetics of carbamazepine-serum protein binding, the carbamazepine free fraction (%) was investigated in the serum of 66 patients, ranging from 4 to 83 years, with epilepsy or trigeminal neuralgia, treated with carbamazepine alone or carbamazepine in combination with phenytoin, phenobarbital, and/or valproic acid, over a relatively long period." | 5.09 | Age-related alteration of carbamazepine-serum protein binding in man. ( Koyama, H; Mori, S; Nakajima, K; Sugioka, N; Uno, A, 1999) |
| "To assess the extent to which adults with epilepsy were optimized and individualized on phenytoin monotherapy in the Western Cape, South Africa and to estimate the average optimized dose and serum phenytoin concentration, and the therapeutic range for this patient group." | 5.09 | Optimization of phenytoin therapy in adults with epilepsy in the Western Cape, South Africa. ( Folb, PI; Kies, BM; Seymour, MA; Valodia, PN, 1999) |
| "Changes in body weight were evaluated in 349 patients from a study comparing efficacy of add-on therapy with tiagabine (TGB), carbamazepine (CBZ) or phenytoin (PHT)." | 5.09 | Total percentage body weight changes during add-on therapy with tiagabine, carbamazepine and phenytoin. ( Bertrand, ME; Deaton, RL; Hogan, RE; Sommerville, KW, 2000) |
| "This prospective observational study explored the efficacy and tolerability of topiramate (TPM) in patients with refractory epilepsy attending a single outpatient clinic." | 5.09 | Topiramate in refractory epilepsy: a prospective observational study. ( Brodie, MJ; Sills, GJ; Stephen, LJ, 2000) |
| "The effects of temperature on binding characteristics of phenytoin (PHT) to serum proteins were determined in adult patients with epilepsy." | 5.09 | Effect of temperature on binding characteristics of phenytoin to serum proteins in monotherapy adult patients with epilepsy. ( Kanemaru, R; Kodama, H; Kodama, Y; Mitsuyama, Y; Shinozawa, S; Todaka, K, 2000) |
| "We compared the cognitive effects of randomly prescribed phenytoin (PHT) and carbamazepine (CBZ) therapy on newly diagnosed patients with epilepsy in a 2-year parallel group follow-up study." | 5.08 | Comparing the cognitive effects of phenytoin and carbamazepine in long-term monotherapy: a two-year follow-up. ( Jokelainen, M; Pulliainen, V, 1995) |
| "Fifty-four out-patients with epilepsy who had been taking phenytoin for more than one year were examined for gingival hyperplasia." | 5.08 | Phenytoin as a risk factor in gingival hyperplasia. ( Kolínová, M; Patzelová, V; Perlík, F; Zvárová, J, 1995) |
| "Our objective was to evaluate the patterns of malformations in children exposed in utero to phenytoin (DPH) and carbamazepine (CBZ) monotherapy, and to compare them prospectively with matched mother-child pairs exposed to nonteratogens, and to separate the effects of antiepileptic drugs (AEDs) from those of epilepsy by collecting groups of untreated epileptics and those treated with DPH and CBZ for conditions other than epilepsy." | 5.08 | Findings in children exposed in utero to phenytoin and carbamazepine monotherapy: independent effects of epilepsy and medications. ( Chitayat, D; Farkas, LD; Koren, G; Nulman, I; Scolnik, D, 1997) |
| "To examine the genetic polymorphism of CYP2C9 and CYP2C19 and its effect on the pharmacokinetics of phenytoin among 44 Japanese patients with epilepsy." | 5.08 | Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy. ( Furusho, K; Hashimoto, Y; Hattori, H; Inui, K; Odani, A; Otsuki, Y; Uwai, Y, 1997) |
| "To compare the effectiveness of monotherapy clobazam (CLB) to carbamazepine (CBZ) and phenytoin (PHT) in children with epilepsy." | 5.08 | Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy. ( , 1998) |
| "We measured the levels of estradiol (E2), total testosterone (TT) and free testosterone (FT) in 24 male patients with epilepsy receiving phenytoin (DPH), 21 male patients with epilepsy receiving cabamazepine (CBZ), 23 male epileptics receiving no treatment, and in 10 healthy age-matched male controls." | 5.07 | [Effects of phenytoin and cabamazepine on sex hormones in male patients with epilepsy: a controlled study]. ( Ma, S; Zhou, S, 1994) |
| "A group of 51 patients with chronic cryptogenic or symptomatic localized epilepsy refractory to therapy with barbiturates underwent progressive substitution with phenytoin or carbamazepine, in standardized and randomized fashion." | 5.07 | Carbamazepine and phenytoin in epilepsies refractory to barbiturates: efficacy, toxicity and mental function. ( Antoniuk, SA; Bigarella, MM; Bittencourt, PR; da Costa, JC; Doro, MP; Ferreira, AS; Fonseca, LC; Gonçalves e Silva, GE; Gorz, AM; Marcourakis, T, 1993) |
| "Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with behavioural measures before medication and after one and six months of treatment." | 5.07 | Psychiatric aspects of epilepsy in childhood treated with carbamazepine, phenytoin or sodium valproate: a random trial. ( Berg, I; Butler, A; Ellis, M; Foster, J, 1993) |
| "The effects of the withdrawal of phenytoin (PT) on cognitive and psychomotor functions of long-term patients in an epilepsy centre were studied." | 5.07 | Effects of withdrawal of phenytoin on cognitive and psychomotor functions in hospitalized epileptic patients on polytherapy. ( Bulmahn, A; May, TW; Rambeck, B; Wohlhüter, M, 1992) |
| "A comparative study of the bioavailability of seven formulations of phenytoin was carried out on 17 patients with epilepsy who were taking phenytoin regularly as part of their drug therapy." | 5.07 | Bioavailability and dissolution of proprietary and generic formulations of phenytoin. ( Richens, A; Soryal, I, 1992) |
| "Twenty severely retarded institutionalized epileptic adults with phenytoin-induced gingival hyperplasia were divided into two groups and received a daily 3 mg capsule of either folic acid or lactose for 16 weeks in a randomized, double-blind, parallel study." | 5.07 | The administration of folic acid to institutionalized epileptic adults with phenytoin-induced gingival hyperplasia. A double-blind, randomized, placebo-controlled, parallel study. ( Beaver, WT; Bottomley, WK; Brown, RS; Di Stanislao, PT, 1991) |
| "Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with cognitive tests before medication and three subsequent times over a year." | 5.07 | Cognitive impairment in new cases of epilepsy randomly assigned to carbamazepine, phenytoin and sodium valproate. ( Berg, I; Butler, R; Forsythe, I; McGuire, R, 1991) |
| "We investigated the neuropsychological effects of carbamazepine, phenobarbital, and phenytoin in 15 partial complex epilepsy patients treated with each drug for 3 months, using a randomized double-blind, triple crossover design." | 5.06 | Comparative cognitive effects of anticonvulsants. ( Gallagher, BB; Huh, K; King, DW; Loring, DW; Meador, KJ, 1990) |
| "It has recently been reported that folic acid supplementation reduced DPH-induced gingival hyperplasia in cat and in a pilot study also in man." | 5.06 | Folate treatment of diphenylhydantoin-induced gingival hyperplasia. ( Bäckman, N; Blomquist, HK; Hänström, L; Heijbel, J; Holm, AK; Säfström, G, 1989) |
| " All the patients had epilepsy that had previously been untreated, and had been randomly assigned to receive carbamazepine, phenytoin, or sodium valproate." | 5.06 | Withdrawal of anticonvulsant drugs in patients free of seizures for two years. A prospective study. ( Callaghan, N; Garrett, A; Goggin, T, 1988) |
| "A prospective, double-blind, placebo-controlled investigation of possible withdrawal symptoms from phenytoin, carbamazepine and sodium valproate is reported in patients with active epilepsy, on combination therapy." | 5.06 | Withdrawal symptoms from phenytoin, carbamazepine and sodium valproate. ( Duncan, JS; Shorvon, SD; Trimble, MR, 1988) |
| "Progabide, an experimental GABA-ergic antiepileptic drug, was given in a placebo-controlled double-blind cross-over trial to 19 adult patients with chronic partial epilepsy refractory to previous high-dose antiepileptic drug therapy." | 5.06 | Progabide for refractory partial epilepsy: a controlled add-on trial. ( Schmidt, D; Utech, K, 1986) |
| "Introduction Phenytoin is a frequently used drug treatment for epilepsy." | 5.05 | An update on CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects. ( Carleton, BC; Chang, WC; Chung, WH; Hung, SI, 2020) |
| "In a double-blind trial of phenytoin for the prevention of postoperative epilepsy in craniotomy patients, epilepsy was observed in 7." | 5.05 | Postoperative epilepsy: a double-blind trial of phenytoin after craniotomy. ( Challen, RG; Frewin, DB; Hanieh, A; Hann, CS; North, JB; Penhall, RK, 1980) |
| "A double-blind trial of phenytoin therapy following craniotomy was performed to test the hypothesis that phenytoin is effective in reducing postoperative epilepsy." | 5.05 | Phenytoin and postoperative epilepsy. A double-blind study. ( Frewin, DB; Hanieh, A; North, JB; Penhall, RK; Taylor, WB, 1983) |
| "Eighty-eight patients with the onset of epilepsy in adult life were randomly allocated to treatment with sodium valproate (600 mg/day), or phenytoin (300 mg/day), and followed up for at least 12 months." | 5.05 | A comparison of phenytoin and valproate in previously untreated adult epileptic patients. ( Chadwick, DW; Rawlins, MD; Turnbull, DM; Weightman, D, 1982) |
| "A double-blind cross-over trial between pheneturide and phenytoin in ninety-four outpatients with epilepsy is described." | 5.05 | A comparison of phenytoin and pheneturide in patients with epilepsy: a double-blind cross-over trial. ( Engler, C; English, JR; Fry, DE; Gawel, MJ; Gibberd, FB; Page, NG; Park, DM; Rose, FC; Scott, G, 1982) |
| "A double blind trial of folic acid against placebo was carried out on out-patients with epilepsy treated with Phenytoin." | 5.05 | The influence of folic acid on the frequency of epileptic attacks. ( Gibberd, FB; Nicholls, A; Wright, MG, 1981) |
| "Despite the widespread use of phenytoin in the treatment of epilepsy, few studies have examined its effects on cognitive functioning." | 5.05 | Phenytoin and cognitive function: effects on normal volunteers and implications for epilepsy. ( Huppert, FA; Thompson, P; Trimble, M, 1981) |
| "The purpose of this clinical study was to evaluate the effect of a 3-min daily toothbrushing with 1% chlorhexidine gluconate toothpaste on dental plaque, gingivitis and gingival hyperplasia in 30 mentally retarded epileptic children treated with phenytoin." | 5.04 | Oral use of chlorhexidine gluconate toothpaste in epileptic children. ( Bay, LM; Russell, BG, 1978) |
| "In double blind crossover 4 month trials, carbamazepine was compared to phenytoin as sole treatment for 45 patients with uncontrolled partial and generalized epilepsy." | 5.04 | Carbamazepine and the electroencephalogram of epileptics: a double blind study in comparison to phenytoin. ( Dodrill, CB; Troupin, AS; Wilkus, RJ, 1978) |
| "To determine the influence of phenytoin (PHT) monotherapy on the serum levels of homocysteine (Hcy), folate and vitamin B12 in patients with epilepsy." | 5.01 | Effects of phenytoin on serum levels of homocysteine, vitamin B12, folate in patients with epilepsy: A systematic review and meta-analysis (PRISMA-compliant article). ( Chen, S; Xia, Z; Xu, H; Xu, S; Xu, Y; Zhang, N, 2019) |
| "To review the time to treatment failure, remission and first seizure with carbamazepine compared with phenytoin when used as monotherapy in people with focal onset seizures (simple or complex focal and secondarily generalised), or generalised onset tonic-clonic seizures (with or without other generalised seizure types)." | 5.01 | Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review. ( Marson, AG; Nevitt, SJ; Tudur Smith, C, 2019) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are fatal adverse cutaneous drug reactions which may be induced by phenytoin (PHT) or lamotrigine (LTG)." | 4.91 | HLA-B*1502 increases the risk of phenytoin or lamotrigine induced Stevens-Johnson Syndrome/toxic epidermal necrolysis: evidence from a meta-analysis of nine case-control studies. ( Huo, J; Li, X; Mei, S; Wang, J; Yu, K; Zhao, Z; Zhu, Y, 2015) |
| " Antiepileptic drugs (AED) such as phenytoin are often used in clinical practice with the hopes of preventing post-traumatic epilepsy." | 4.91 | Pharmacological treatments for preventing epilepsy following traumatic head injury. ( Abel, H; Campbell, LA; Pohlmann-Eden, B; Thompson, K, 2015) |
| "Small sample size, poor methodological quality and lack of data on important outcome measures prevent any meaningful conclusions regarding the efficacy and safety of sulthiame as monotherapy in epilepsy." | 4.90 | Sulthiame monotherapy for epilepsy. ( Marson, AG; Milburn-McNulty, P; Powell, G; Sills, GJ, 2014) |
| "In this systematic review we present information relating to the effectiveness and safety of the following interventions: monotherapy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs (lamotrigine or levetiracetam) for drug-resistant epilepsy; and hemispherectomy for drug-resistant epilepsy." | 4.88 | Epilepsy (generalised). ( Maguire, M; Marson, AG; Ramaratnam, S, 2012) |
| "In this systematic review we present information relating to the effectiveness and safety of the following interventions: antiepileptic drugs after a single seizure; monotherapy for partial epilepsy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs for drug-resistant partial epilepsy (allopurinol, eslicarbazepine, gabapentin, lacosamide, lamotrigine, levetiracetam, losigamone, oxcarbazepine, retigabine, tiagabine, topiramate, vigabatrin, or zonisamide); antiepileptic drug withdrawal for people with partial or generalised epilepsy who are in remission; behavioural and psychological treatments for partial or generalised epilepsy (biofeedback, cognitive behavioural therapy (CBT), educational programmes, family counselling, relaxation therapy (alone or plus behavioural modification therapy, yoga); and surgery for drug-resistant temporal lobe epilepsy ( lesionectomy, temporal lobectomy, vagus nerve stimulation as adjunctive therapy)." | 4.87 | Epilepsy (partial). ( Maguire, M; Marson, AG; Ramaratnam, S, 2011) |
| "Long-term use of phenytoin (PHT) causes gingival hyperplasia; however, little is known about the oral side effects of other antiepileptic drugs (AEDs)." | 4.87 | The effects of antiepileptic drugs on oral health. ( Aragon, CE; Burneo, JG; Cornacchio, AL, 2011) |
| "In this systematic review we present information relating to the effectiveness and safety of the following interventions: monotherapy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs (lamotrigine or levetiracetam) for drug-resistant epilepsy; and hemispherectomy for drug-resistant epilepsy." | 4.86 | Epilepsy (generalised). ( Maguire, M; Marson, AG; Ramaratnam, S, 2010) |
| "In this systematic review we present information relating to the effectiveness and safety of the following interventions: antiepileptic drugs after a single seizure; monotherapy for partial epilepsy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs for drug-resistant partial epilepsy (allopurinol, eslicarbazepine, gabapentin, lacosamide, lamotrigine, levetiracetam, losigamone, oxcarbazepine, retigabine, tiagabine, topiramate, vigabatrin, or zonisamide); antiepileptic drug withdrawal for people with partial or generalised epilepsy who are in remission; behavioural and psychological treatments for partial or generalised epilepsy (biofeedback, cognitive behavioural therapy (CBT), educational programmes, family counselling, relaxation therapy (alone or plus behavioural modification therapy, yoga); and surgery for drug-resistant temporal lobe epilepsy ( lesionectomy, temporal lobectomy, vagus nerve stimulation as adjunctive therapy)." | 4.86 | Epilepsy (partial). ( Maguire, M; Marson, AG; Ramaratnam, S, 2010) |
| "To review the best evidence comparing oxcarbazepine and phenytoin when used as monotherapy in patients with epilepsy." | 4.83 | Oxcarbazepine versus phenytoin monotherapy for epilepsy. ( Marson, AG; Muller, M; Williamson, PR, 2006) |
| "The introduction of these new antiepileptic drugs, from felbamate to levetiracetam, raised hope of control of epilepsy with fewer adverse effects and improved quality of life." | 4.81 | New antiepileptic drug therapies. ( Bergin, AM; Connolly, M, 2002) |
| "The antiepileptic drug hypersensitivity syndrome (AHS) is an adverse drug reaction associated with the aromatic antiepileptic drugs (AEDs) phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), and primidone." | 4.80 | Antiepileptic drug hypersensitivity syndrome. ( Schlienger, RG; Shear, NH, 1998) |
| "Side effects of certain drugs such as cyclosporin A (CsA) and phenytoin may induce gingival overgrowth which in some instances become unacceptable to the patient because esthetic, functional, and other effects." | 4.80 | Reduction of severe gingival overgrowth in a kidney transplant patient by replacing cyclosporin A with tacrolimus. ( Arriba, L; de Andrés, A; Hernández, G; Lucas, M, 2000) |
| " Phenytoin has been used with much clinical success against all types of epileptiform seizures, except petit mal epilepsy, for over 50 years." | 4.79 | Basis of the antiseizure action of phenytoin. ( Tunnicliff, G, 1996) |
| "The major established drugs used in the management of epilepsy are carbamazepine, valproic acid, phenytoin, phenobarbital, primidone, ethosuximide and benzodiazepine drugs." | 4.79 | Established antiepileptic drugs. ( Perucca, E, 1996) |
| "This article provides an analysis of the degree of agreement between in vivo interaction studies performed in patients with epilepsy and healthy individuals, and in vitro studies which identified the cytochromes P450 (CYP) inhibited by felbamate and those involved in its metabolism." | 4.79 | Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation. ( Banfield, CR; Glue, P; Levy, RH; Mather, GG; Perhach, JL; Racha, JK, 1997) |
| "We present a case of a 29-year-old female with a history of epilepsy who was admitted for convulsive status epilepticus (CSE), which was controlled by intravenous VPA, as well as oral VPA and phenytoin." | 4.31 | Valproate-related hyperammonemic encephalopathy with generalized suppression EEG: a case report. ( Liu, X; Peng, X, 2023) |
| "This study was conducted to examine and verify the use of saliva as an alternative matrix for monitoring phenytoin drug levels in patients with epilepsy." | 4.02 | Use of Saliva as an Alternative Matrix to Serum/Plasma for Therapeutic Drug Monitoring Using Reverse-Phase HPLC. ( Ashraf, Z; Farhat, S; Rather, MY, 2021) |
| "The active drugs lamotrigine, oxcarbazepine, and phenobarbital were significantly associated with gingival overgrowth in 61%, 71%, and 53% of cases, respectively, and phenytoin, valproic acid, and carbamazepine in 50%, 44%, and 32% of cases, respectively." | 4.02 | Gingival overgrowth induced by anticonvulsant drugs: A cross-sectional study on epileptic patients. ( Bonvento, G; Gallo, C; Mucignat-Caretta, C; Zagotto, G, 2021) |
| " In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i." | 4.02 | Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021) |
| " In this study, we examined the effect of both acute and chronic treatment with moclobemide on seizures and the action of first-generation antiepileptic drugs: valproate, carbamazepine, phenobarbital and phenytoin." | 4.02 | Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice. ( Banach, M; Borowicz-Reutt, KK, 2021) |
| "There was higher frequency of breakthrough seizures during immediate-release phenytoin capsule usage than during extended-release phenytoin capsule usage by epilepsy patients." | 3.96 | Budget Impact Analysis of Extended-Release Phenytoin Capsules Compared With Immediate-Release Phenytoin Capsules for Patients With Epilepsy in Thailand. ( Suthipinijtham, P; Tiamkao, S, 2020) |
| " Epilepsy-associated comorbid depression was evaluated by tail suspension test, sucrose preference test, and plasma corticosterone levels, whereas epilepsy-associated memory deficit condition was assessed by step-through paradigm, Morris water maze, and nitrite levels." | 3.96 | Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice. ( Goel, RK; Kaur, S; Sharma, NK, 2020) |
| " She had a history of symptomatic epilepsy, which was successfully treated with phenytoin and phenobarbital." | 3.91 | Drug-drug interactions among drugs prescribed for nontuberculous mycobacterial infection and epilepsy: A case report. ( Hatanaka, M; Ikeda, R; Matsumoto, N; Oda, Y; Sonoda, J; Tazaki, T; Yoshikawa, N, 2019) |
| "To examine the influence of obesity and sex on phenytoin LDs." | 3.91 | Evaluation of Intravenous Phenytoin and Fosphenytoin Loading Doses: Influence of Obesity and Sex. ( Alaniz, C; Burghardt, D; DasGupta, R, 2019) |
| " As first-line drug phenobarbital was the most common choice, it was used in 79% of cases of acute symptomatic seizures, in 63% of structural epilepsy, in 42% of genetic epilepsies." | 3.91 | Influence of etiology on treatment choices for neonatal seizures: A survey among pediatric neurologists. ( Capovilla, G; Consonni, D; De Liso, P; Di Capua, M; Dilena, R; Falsaperla, R; Pisani, F; Pruna, D; Suppiej, A; Vitaliti, G, 2019) |
| " Pentylenetetrazole- (PTZ) and pilocarpine-induced seizures are well-established models of human epilepsy." | 3.91 | The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure. ( Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Rezaeian-Varmaziar, H; Shafaat, O, 2019) |
| "Cerebellar ataxia is present in 40% of patients with epilepsy and chronic exposure to phenytoin." | 3.88 | Phenytoin-related ataxia in patients with epilepsy: clinical and radiological characteristics. ( Aeschlimann, DP; Aeschlimann, PC; Dennis, GJ; Grünewald, RA; Hadjivassiliou, M; Hoggard, N; Howell, SJ; Reuber, M; Shanmugarajah, PD, 2018) |
| "The goal of our study was to investigate the incidence of Stevens-Johnson syndrome (SJS), the frequency of SJS diagnosis, and the association between SJS and prior use of allopurinol, carbamazepine or phenytoin." | 3.88 | Incidence of Stevens-Johnson syndrome following combination drug use of allopurinol, carbamazepine and phenytoin in Taiwan: A case-control study. ( Cheng, CY; Cheng, FJ; Chuang, PC; Huang, YS; Pan, HY; Syu, FK, 2018) |
| " Phenytoin induced dystonia." | 3.88 | Phenytoin induced dystonia. ( Acar, T; Alkan, G; Çaksen, H; Cander, B; Ergin, M; Ertekin, B; Koçak, S, 2018) |
| "Phenytoin (PHE) and carbamazepine (CBZ) are first rank causative drugs that can induce drug rash with eosinophilia and systemic symptoms (DRESS) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)." | 3.88 | Evaluation of a lymphocyte transformation test and cytokine detection assay to identify phenytoin and carbamazepine provoked DRESS or SJS/TEN in epilepsy patients. ( Kumkamthornkul, P; Srinoulprasert, Y; Tansit, T; Tuchinda, P; Udnaen, S, 2018) |
| " He had been administered phenytoin and gabapentin for the treatment of symptomatic traumatic epilepsy 8 years before." | 3.88 | Hypothyroidism induced by phenytoin and gabapentin: A Case Report. ( Ishii, K; Miyake, Z; Tamaoka, A, 2018) |
| "We selected and screened for mutations a group of 24 epileptic patients who experienced significant gingival overgrowth following phenytoin therapy." | 3.85 | Lack of pathogenic mutations in SOS1 gene in phenytoin-induced gingival overgrowth patients. ( Consoli, F; De Luca, A; Di Bonaventura, C; Giallonardo, AT; Guida, V; Margiotti, K; Pascolini, G; Pizzuti, A, 2017) |
| "A 71-year-old male with history of epilepsy was admitted for seizures and traumatic brain injury and intravenous fosphenytoin and levetiracetam were initiated." | 3.85 | Fosphenytoin-induced purple glove syndrome: A case report. ( Blunck, JR; Croom, JE; Fields, RK; Newman, JW, 2017) |
| "Recent adverse event reports have raised the question of increased angioedema risk associated with exposure to levetiracetam." | 3.85 | Risk of angioedema associated with levetiracetam compared with phenytoin: Findings of the observational health data sciences and informatics research network. ( Banda, JM; Duke, JD; Hripcsak, G; Jin, P; Khoma, Y; Reich, C; Ryan, PB; Schuemie, MJ; Schwalm, MS; Shah, NH; Suchard, MA; Wu, Y; Xu, H, 2017) |
| "Phenytoin monotherapy may cause a significant increase in the levels of serum homocysteine and a significant decrease in the serum folate and vitamin B12 levels in children with epilepsy, and the significant changes in above mentioned parameters occur early in the course of treatment." | 3.85 | Homocysteine Metabolism and Hematological Parameters in Early Stage of Phenytoin Treated Epileptic Children. ( Sharma, TK; Sitaraman, S; Vardey, SK, 2017) |
| "Sotalol as a drug blocking β-receptors and potassium KCNH2 channels may interact with different substances that affect seizures." | 3.85 | Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model. ( Banach, M; Borowicz-Reutt, KK; Popławska, M, 2017) |
| "5 times lower than the currently available enzyme-multiplied immunoassay technique (EMIT) for measurement of phenytoin in epilepsy patients." | 3.85 | Therapeutic Drug Monitoring of Phenytoin by Simple, Rapid, Accurate, Highly Sensitive and Novel Method and Its Clinical Applications. ( Guo, R; Shaikh, AS, 2017) |
| "In this cross-sectional observational study we enrolled consecutive children aged 2-12 years with epilepsy who had received phenytoin or carbamazepine monotherapy for >6 months." | 3.85 | Hyperhomocysteinaemia in children receiving phenytoin and carbamazepine monotherapy: a cross-sectional observational study. ( Attri, SV; Chandrasekaran, S; Patil, S; Sahu, JK; Sankhyan, N; Singhi, P; Suthar, R; Tageja, M, 2017) |
| "The PPK model, using the power scaling of body weight, effectively elucidated the topiramate serum concentration profile ranging from pediatric to adult patients." | 3.85 | Population Pharmacokinetics of Topiramate in Japanese Pediatric and Adult Patients With Epilepsy Using Routinely Monitored Data. ( Ikeda, A; Ito, S; Matsubara, K; Sugimoto, M; Takeuchi, M; Yamamoto, S; Yano, I; Yonezawa, A, 2017) |
| "After excluding patients in the monotherapy group with vascular etiology or previous cardiovascular events, in the remaining 400 patients, enzyme-inducer AEDs (EIAEDs), especially phenytoin (PHT), were associated with higher prevalence of dyslipidemia (PRa 1." | 3.85 | Prevalence of cardiovascular risk factors in people with epilepsy. ( Díez, L; Elosua, R; Gomez, A; Moreira, A; Roquer, J; Vivanco-Hidalgo, RM, 2017) |
| "We aimed to explore the possible influence of CYP2C9 (*2, *3 and IVS8-109 A>T), CYP2C19 (*2, *3 and *17) and ABCB1 (1236C>T, 2677G>A/T and 3435C>T) on phenytoin (PHT) plasma concentrations in 64 Mexican Mestizo (MM) patients with epilepsy currently treated with PHT in mono- (n=25) and polytherapy (n=39)." | 3.83 | CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy. ( Dorado, P; Familiar-López, I; Fricke-Galindo, I; Jung-Cook, H; LLerena, A; López-López, M; Martínez-Juárez, IE; Monroy-Jaramillo, N; Ortega-Vázquez, A; Peñas-Lledó, E, 2016) |
| "To identify the factors influencing topiramate pharmacokinetics (PK) in a large population of adult patients with epilepsy using population PK analysis." | 3.83 | Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis. ( Bae, EK; Jang, IJ; Kim, TJ; Lee, J; Lee, KJ; Lee, SK; Moon, J; Shin, D; Shin, JW; Shin, YW, 2016) |
| "Although it has been reported that some antiepileptic drugs have inducing or inhibiting effects on lamotrigine (LTG) clearance, whether they have the same effects in Asian epilepsy patients as in those in other countries has not been clarified, especially in children." | 3.83 | The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy. ( Abe, S; Azuma, Y; Ishihara, N; Ito, Y; Itomi, K; Kidokoro, H; Kojima, S; Kurahashi, H; Kurahashi, N; Maruyama, K; Natsume, J; Negoro, T; Okumura, A; Suzuki, M; Takeuchi, T; Tsuji, T; Watanabe, K; Yamada, K; Yamamoto, H, 2016) |
| "We compared persistence of antiepileptic drugs (AEDs) including carbamazepine, oxcarbazepine, gabapentin, lamotrigine, topiramate, valproic acid, and phenytoin in an Asian population with epilepsy." | 3.83 | Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study. ( Hsieh, CY; Huang, CW; Lai, EC; Lin, SJ; Setoguchi, S; Su, CC; Yang, YK, 2016) |
| " This compound was effective in delaying onset of PTZ-evoked seizures at the dose of 5mg/kg in kindled animals and significantly reduced oxidative stress better than standard drug phenobarbital (PB)." | 3.81 | Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents. ( Kumari, S; Mishra, CB; Tiwari, M, 2015) |
| "Lamotrigine (LTG) is a widely used antiepileptic-drug (AED) for the treatment of epilepsy." | 3.81 | Effect of comedication on lamotrigine clearance in Korean epilepsy patients. ( Hong, SB; Joo, EY; Kim, HJ; Kim, TE; Lee, SY; Seo, DW, 2015) |
| "Phenytoin has a widespread use in epilepsy treatment and is mainly metabolized by hepatic cytochrome P450 enzymes (CYP)." | 3.81 | The effect of polymorphic metabolism enzymes on serum phenytoin level. ( Ergeç, D; Gulcebi, MI; Guney, I; Onat, FY; Ozkara, C; Ozkaynakci, A; Ulucan, K; Uzan, M, 2015) |
| " We genotyped normal and epileptic patient cohorts of monoethnic population of Kashmir valley for CYP2C9 gene and allelic polymorphism and investigated the effect of CYP2C9*2 and *3 polymorphism on the Pharmacokinetic and therapeutic and/or adverse pharmacodynamic responses to Phenytoin in the idiopathic epilepsy patients." | 3.81 | Clinical relevance of genetic polymorphism in CYP2C9 gene to pharmacodynamics and pharmacokinetics of phenytoin in epileptic patients: validatory pharmacogenomic approach to pharmacovigilance. ( Andrabi, KI; Jan, TR; Kousar, S; Wafai, ZA; Wani, MA, 2015) |
| " We evaluated influence of DHA on anticonvulsant activity of AEDs phenytoin, valproate, and lamotrigine in maximal electroshock (MES), pentylenetetrazole (PTZ), and kindling models of epilepsy." | 3.81 | Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. ( Babapour, V; Gavzan, H; Sardari, S; Sayyah, M, 2015) |
| "Phenytoin has a narrow therapeutic window and seizures can occur at both ends of the spectrum." | 3.81 | Paradoxical Seizure Response to Phenytoin in an Epileptic Heroin Addict. ( Dewberry, RG; Pula, T; Vasagar, B; Verma, BR, 2015) |
| "A 49-year-old-male has been treated with phenytoin for epilepsy for more than ten years." | 3.81 | Potentially Unsafe Herb-drug Interactions Between a Commercial Product of Noni Juice and Phenytoin- A Case Report. ( Chen, MH; Kang, YC; Lai, SL, 2015) |
| "To examine the effects of cytochrome P450 3A4 (CYP3A4), cytochrome P450 3A5 (CYP3A5) and ATP-binding cassette sub-family B member 1 (ABCB1) genetic polymorphisms on carbamazepine (CBZ) plasma concentrations in Chinese patients with epilepsy using CBZ as monotherapy and bitherapy with phenytoin (PHT), phenobarbital (PB), or valproic acid (VPA)." | 3.81 | Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy. ( Liu, DQ; Ma, HY; Sheng, YH; Wang, C; Wang, P; Yin, T; Zhou, BT, 2015) |
| "Valproic acid (VPA), which is widely used to treat epilepsy, migraine, and bipolar disorder, can causes severe hyperammonemia." | 3.81 | Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy. ( Hirai, K; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y, 2015) |
| "A 12-year-old patient with refractory epilepsy syndrome presented with phenytoin toxicity, following a concomitant treatment with phenytoin, valproic acid, and lamotrigine." | 3.80 | Drug interaction between phenytoin and valproic acid in a child with refractory epilepsy: a case report. ( Carnevale, RC; Carvalho, IV; de Fátima Lopes Ambrósio, R; de Queiroz, RA; dos Reis, MC; Mazzola, PG; Moriel, P; Visacri, MB, 2014) |
| "Lacosamide (LCM), a new antiepileptic drug (AED) approved as adjunctive therapy for the treatment of patients with partial-onset seizures, has limited pharmacokinetic and drug interaction data." | 3.80 | Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs. ( Duncan, JS; Markoula, S; Patsalos, PN; Ratnaraj, N; Sander, JW; Teotonio, R, 2014) |
| "The "anticonvulsant face," with a short nose, broad nasal bridge, epicanthal folds, and wide mouth, was described in the 1970s in children who had been exposed during pregnancy to the anticonvulsant drugs phenytoin and phenobarbital." | 3.80 | Laser light scan analysis of the "anticonvulsant face". ( Deutsch, CK; Holmes, LB; Orup, HI, 2014) |
| "Valproic acid, which is widely used to treat various types of epilepsy, may cause severe hyperammonemia." | 3.80 | 4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. ( Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Miyakawa, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R, 2014) |
| " Pentylenetetrazole (PTZ)-kindled and spontaneous model of epilepsy (EL) mice were used as models of chemically induced and spontaneous epilepsy, respectively." | 3.80 | Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models. ( Ohtsuki, S; Terasaki, T; Uchida, Y, 2014) |
| "To facilitate therapeutic monitoring of antiepileptic drugs (AEDs) by healthcare professionals for patients with epilepsy (PWE), we applied a GC-MS assay to measure three AEDs: carbamazepine (CBZ), phenytoin (PHT) and valproic acid (VPA) levels concurrently in one dried blood spot (DBS), and validated the DBS-measured levels to their plasma levels." | 3.80 | Clinical validation and implications of dried blood spot sampling of carbamazepine, valproic acid and phenytoin in patients with epilepsy. ( Ho, PC; Kong, ST; Kumar, PK; Lee, WB; Lim, SH; Ng, YL; Wang, HY; Wong, PS, 2014) |
| " Adults with a history of epilepsy who used a generic phenytoin and whose therapy was switched to another generic phenytoin between January 2012 and June 2013 were included (n = 80)." | 3.80 | Switching between phenytoin generics in patients with epilepsy may lead to increased risk of breakthrough seizure: chart analysis and practice recommendations. ( Chu, K; Jung, KH; Lee, SK; Lee, ST; Moon, J; Shin, JW, 2014) |
| " He had a complex medical history including epilepsy controlled with long-term phenytoin." | 3.79 | When less is more: a case of phenytoin toxicity. ( Arnold, I; Robertson, K; von Stempel, CB, 2013) |
| "We report two cases of drug rash with eosinophilia and systemic symptoms (DRESS) associated with the use of carbamazepine and phenytoin in Brazilian boys tested for human leukocyte antigen (HLA) class I and II alleles." | 3.79 | HLA typing in Brazilian boys with aromatic antiepileptic drug-induced DRESS. ( Cuman, RK; Gaeti, WP; Moliterno, RA; Obreli-Neto, PR; Schiavon, GB, 2013) |
| "The results indicated an increased risk of hypothyroidism among patients using AEDs, especially phenytoin, valproate, phenobarbital, carbamazepine, and oxcarbazepine." | 3.79 | Use of antiepileptic drugs and risk of hypothyroidism. ( Hsieh, CY; Lai, EC; Lin, SJ; Yang, YH, 2013) |
| "Cognitive impairment implicates many factors beyond phenytoin monotherapy in patients with epilepsy." | 3.79 | Association of apolipoprotein E ε4 allele with cognitive impairment in patients with epilepsy and interaction with phenytoin monotherapy. ( Ganesvaran, RA; Narmadha, MP; Palanisamy, A; Rajendran, NN, 2013) |
| "We recruited ambulatory young adults with epilepsy who were taking phenytoin." | 3.79 | The association between BsmI polymorphism and bone mineral density in young patients with epilepsy who are taking phenytoin. ( Geater, A; Leelawattana, R; Limapichart, K; Phabphal, K; Sathirapanya, P; Setthawatcharawanich, S; Thammakumpee, N; Witeerungrot, N, 2013) |
| "Phenytoin is known to be able to induce cerebellar atrophy in patients with epilepsy." | 3.79 | The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy. ( Borgio, JG; De Paola, L; Scola, RH; Silvado, C; Twardowschy, CA; Werneck, LC, 2013) |
| "Clinical studies indicate that phenytoin prevents acute post-traumatic seizures but not subsequent post-traumatic epilepsy." | 3.78 | Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro. ( Berdichevsky, Y; Dzhala, V; Mail, M; Staley, KJ, 2012) |
| "We recruited 98 patients with epilepsy (45 taking phenytoin, 27 taking valproate, and 26 not taking any AED)." | 3.78 | Characterization of glucose homeostasis and lipid profile in adult, seizure-free, epileptic patients in Asian population. ( Geater, A; Limapichat, K; Phabphal, K; Sathirapanya, P; Setthawatcharawanich, S, 2012) |
| "Asians who carry the HLA-B*1502 allele have an elevated risk of developing Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) when treated with the antiepileptic drugs (AEDs) carbamazepine (CBZ) and phenytoin (PHT)." | 3.78 | Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore. ( Dong, D; Finkelstein, EA; Sung, C, 2012) |
| " Using this assay, we examined polymorphisms in 20 Japanese pediatric patients prescribed phenytoin for the treatment of epilepsy, and classified their polymorphisms into four groups: group I, CYP2C9*1/*1 and CYP2C19*1/*1; group II, CYP2C9*1/*1 and CYP2C19*1/*2 or *1/*3; group III, CYP2C9*1/*1 and CYP2C19*2/*2; and group IV, CYP2C9*1/*3 and CYP2C19*1/*2 or *1/*3." | 3.77 | [Development of rapid genotyping methods for single nucleotide polymorphisms of cytochrome P450 2C9 (CYP2C9) and cytochrome P450 2C19 (CYP2C19) and their clinical application in pediatric patients with epilepsy]. ( Ikumi, Y; Kagawa, Y; Mishima, N; Nishimura, S; Takahashi, Y; Yamamoto, Y, 2011) |
| " The distribution of variant CYP2C9 alleles and prevalence of phenytoin adverse reactions were hereby investigated in a population of patients diagnosed with epilepsy." | 3.77 | CYP2C9 polymorphism in patients with epilepsy: genotypic frequency analyzes and phenytoin adverse reactions correlation. ( De Paola, L; Scola, RH; Silvado, CE; Twardowschy, CA; Werneck, LC, 2011) |
| "A retrospective cohort study using a large health insurance plan claims database comparing patients with epilepsy who switched from brand to generic equivalent phenytoin, lamotrigine, or divalproex after 6 months (switch cohorts) to matched patients who remained on the brand (nonswitch cohorts)." | 3.77 | Clinical and pharmacy utilization outcomes with brand to generic antiepileptic switches in patients with epilepsy. ( Curtis, B; Erickson, SC; Harada, AS; Le, L; Ramsey, SD; Solow, BK; Stockl, KM; Zakharyan, A, 2011) |
| "Relationships between reproductive hormone levels, bone turnover marker levels, bone mineral density, and rates of bone loss were evaluated in premenopausal women with epilepsy taking enzyme-inducing antiepileptic drugs (EIAEDs: phenytoin or carbamazepine) or lamotrigine." | 3.77 | Normal vitamin D and low free estradiol levels in women on enzyme-inducing antiepileptic drugs. ( McMahon, DJ; Morrell, MJ; Pack, AM; Shane, E, 2011) |
| "Children aged 5 to 12 years with diagnosed epilepsy who received phenytoin monotherapy seen in the neurological clinic at Queen Sirikit National Institute of Child Health were studied." | 3.77 | Correlation between serum and salivary phenytoin concentrations in Thai epileptic children. ( Jaiweerawattana, U; Liamsuwan, S, 2011) |
| "Fosphenytoin was developed to eliminate the poor aqueous solubility and irritant properties of intravenous phenytoin." | 3.77 | New anticonvulsant drugs. Focus on flunarizine, fosphenytoin, midazolam and stiripentol. ( Bebin, M; Bleck, TP, 1994) |
| "The DNS II acetone fraction of Delphinium nordhagenii has exhibited the anticonvulsant actions by preventing the seizures against PTZ- and picrotoxin-induced seizure as well as 100% seizure protection in MES test." | 3.76 | Anticonvulsant activity of DNS II fraction in the acute seizure models. ( Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M, 2010) |
| "In this study of older adults with epilepsy, lamotrigine was the most effective AED as measured by 12-month retention and seizure freedom, with levetiracetam a close second." | 3.76 | Comparative effectiveness of 10 antiepileptic drugs in older adults with epilepsy. ( Arif, H; Bazil, CW; Buchsbaum, R; Hirsch, LJ; Pierro, J; Resor, SR; Sims, J; Whalen, M, 2010) |
| " The purpose of this study was to determine the allele and genotype frequencies of such genetic variants in patients with epilepsy from North India administered first-line antiepileptic drugs, such as phenobarbitone, phenytoin, carbamazepine and valproic acid, and compare them with worldwide epilepsy populations." | 3.76 | Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment. ( Baghel, R; Bala, K; Brahmachari, SK; Giddaluru, S; Gourie-Devi, M; Grover, S; Gupta, M; Kaur, H; Kaur, K; Kukreti, R; Narayanasamy, K; Sharma, A; Sharma, S; Talwar, P; Varma, B, 2010) |
| " She was receiving phenytoin for epilepsy for 2 years." | 3.76 | Phenytoin induced vitamin D deficiency presenting as proximal muscle weakness. ( Aggarwal, A; Faridi, MM, 2010) |
| " The influence of age and concomitant medications on the dose/concentration ratio of levetiracetam was examined in 103 children with epilepsy." | 3.76 | Age and comedications influence levetiracetam pharmacokinetics in children. ( Dahlin, MG; Ohman, I; Wide, K, 2010) |
| "Phenytoin, one of the most common antiepileptic drugs, is a major cause of antiepileptic drug hypersensitivity syndrome (AHS), which is a rare but potentially fatal complication." | 3.75 | Agranulocytosis following phenytoin-induced hypersensitivity syndrome. ( Imai, K; Ito, S; Oguni, H; Osawa, M; Sasaki, K; Shioda, M, 2009) |
| "Between 1999 and 2004, we enrolled pregnant women with epilepsy who were taking a single antiepileptic agent (carbamazepine, lamotrigine, phenytoin, or valproate) in a prospective, observational, multicenter study in the United States and the United Kingdom." | 3.75 | Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. ( Baker, GA; Browning, N; Clayton-Smith, J; Cohen, M; Combs-Cantrell, DT; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2009) |
| "To determine the utility and tolerability of levetiracetam (LEV) compared to phenytoin (PHT) in preventing clinical seizures in patients with subarachnoid hemorrhage (SAH)." | 3.75 | Utility of levetiracetam in patients with subarachnoid hemorrhage. ( Husain, AM; Shah, D, 2009) |
| "(1) Numerous follow-up studies of pregnancies in women with epilepsy show that valproic acid is more teratogenic than other antiepileptics." | 3.75 | Valproic acid: long-term effects on children exposed in utero. ( , 2009) |
| "Phenytoin has a wide range of pharmacologic effects other than its anticonvulsant activity." | 3.75 | Phenytoin revisited. ( Finkel, MJ, 1984) |
| "Phenytoin (PHT) is widely used to treat epilepsy in elderly patients, but information on its pharmacokinetics in this population is limited." | 3.74 | Phenytoin half-life and clearance during maintenance therapy in adults and elderly patients with epilepsy. ( Ahn, JE; Birnbaum, AK; Brundage, RC; Cloyd, JC; Conway, JM; Leppik, IE; Marino, SE; Musib, LC; Ramsay, RE; Rarick, JO; White, JR, 2008) |
| "Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) in Han Chinese, but not in Caucasian populations." | 3.74 | Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. ( Desudchit, T; Hirankarn, N; Kangwanshiratada, O; Korkij, W; Limotai, C; Locharernkul, C; Loplumlert, J; Shotelersuk, V; Suphapeetiporn, K; Tongkobpetch, S, 2008) |
| " Hyperhomocysteinemia was defined as fasting total Hcy above 12 micromol/L and/or post-methionine load concentrations above 38 micromol/L." | 3.74 | Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins. ( Apeland, T; Frøyland, ES; Kristensen, O; Mansoor, MA; Strandjord, RE, 2008) |
| "Both levetiracetam (LEV) and phenytoin (PHT) were associated with a low risk of early postoperative seizures and a moderate risk of later epilepsy." | 3.74 | Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery. ( Bromfield, EB; Hurwitz, S; Milligan, TA, 2008) |
| "The present work was undertaken to examine the central pharmacokinetics of phenytoin (PHT) in an experimental model of epilepsy, induced by administration of 3-mercaptopropionic acid (MP), and possible participation of P-glycoprotein in this model of epilepsy." | 3.74 | Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model. ( Auzmendi, J; Bramuglia, GF; Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Opezzo, JA; Taira, CA, 2007) |
| "Ecto-nucleotidases, one of the main mechanisms involved in the control of adenosine levels in the synaptic cleft, have shown increased activities after the pilocarpine model of epilepsy." | 3.74 | Antiepileptic drugs prevent changes induced by pilocarpine model of epilepsy in brain ecto-nucleotidases. ( Bogo, MR; Bonan, CD; Bruno, AN; Cognato, Gde P; da Silva, RS; Sarkis, JJ, 2007) |
| "A previous study conducted in Taiwan found a 100% association between HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine-tolerant subjects (odds ratio = 2,504)." | 3.74 | Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese. ( Baum, L; Cheng, AS; Kwan, P; Lau, KM; Man, CB; Ng, MH; Yu, E, 2007) |
| "Using the mouse maximal electroshock-induced seizure model, indicative of tonic-clonic seizures in humans, the present study was aimed at characterizing the interaction between remacemide and valproate, carbamazepine, phenytoin, and phenobarbital." | 3.74 | Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ; Malek, R; Patsalos, PN; Ratnaraj, N, 2007) |
| "Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been associated with some drugs, particularly anticonvulsants such as phenytoin." | 3.74 | [Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy]. ( Fernández, FA; Garcés, FJ; Pintor, E; Quesada, R, 2007) |
| "On the basis of epileptic model induced by pentylenetetrazol (PTZ), cognitive impairment model was induced by kindling epilepsy with PTZ everyday, which were then di-vided into the model-1 group, the CZD-1 group, the nimodipine-1 group, and those by injecting large dosage phenytoin sodium were divided into the model-2 group, the CZD-2 group and the nimodipine-2 group." | 3.74 | [Influence of repeated seizures and large dosage anti-epileptic drug on phosphorylated cAMP response element binding protein in rat's hippocampus and effect of Caoguo Zhimu Decoction]. ( He, J; Ma, SL, 2007) |
| "To compare the temporal pattern of seizures after acute withdrawal of oxcarbazepine (OXC) and phenytoin (PHT) in the epilepsy monitoring unit (EMU)." | 3.74 | Temporal pattern of oxcarbazepine and phenytoin withdrawal seizures during epilepsy monitoring. ( Abou-Khalil, BW; Azar, NJ; Song, Y; Wang, L, 2008) |
| " We previously reported biochemical evidence of increased bone turnover in premenopausal women with epilepsy on phenytoin monotherapy compared with those on carbamazepine, lamotrigine, and valproate." | 3.74 | Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy. ( McMahon, DJ; Morrell, MJ; Pack, AM; Randall, A; Shane, E, 2008) |
| "This is the first report demonstrating an association between the SCN1A polymorphism and carbamazepine-resistant epilepsy." | 3.74 | Association between SCN1A polymorphism and carbamazepine-resistant epilepsy. ( Abe, T; Hori, M; Ishitsu, T; Nakagawa, K; Nakagawa, T; Seo, T, 2008) |
| " We studied premenopausal women with epilepsy receiving antiepileptic drug monotherapy (phenytoin, carbamazepine, valproate, and lamotrigine)." | 3.73 | Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy. ( Doñe, S; Flaster, E; Holloway, L; Marcus, R; Morrell, MJ; Pack, AM; Randall, A; Seale, C; Shane, E, 2005) |
| "Across a range of assumptions used, the risk of hospitalization for Stevens-Johnson syndrome or toxic epidermal necrolysis in new users is low for carbamazepine, lamotrigine, phenytoin, phenobarbital, and valproic acid." | 3.73 | Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics. ( Messenheimer, J; Mockenhaupt, M; Schlingmann, J; Tennis, P, 2005) |
| "3 in a fetus exposed to phenytoin during pregnancy." | 3.73 | A fragile site at 10q23 (FRA10A) in a phenytoin-exposed fetus: a case report and review of the literature. ( Désilets, V; Duncan, AM; Morel, CF, 2005) |
| " In this study the anticonvulsant actions of norfluoxetine and fluoxetine were studied and compared to those of phenytoin and clonazepam in pentylenetetrazol-induced mouse epilepsy models." | 3.73 | Norfluoxetine and fluoxetine have similar anticonvulsant and Ca2+ channel blocking potencies. ( Harasztosi, C; Kecskeméti, V; Nánási, PP; Pál, B; Riba, P; Rusznák, Z; Szûcs, G; Wagner, R, 2005) |
| "We report a patient with epilepsy who presented with acute onset of left hemiparesis associated with phenytoin intoxication due to interaction with clobazam." | 3.73 | Benign angiopathy of the central nervous system associated with phenytoin intoxication. ( Kume, A; Nagao, H; Nakano, N; Wakamoto, H, 2006) |
| " The AEDs received by the mothers with epilepsy were Phenytoin, Carbamazepine, and Sodium valproate." | 3.73 | Physical growth and psychomotor development of infants exposed to antiepileptic drugs in utero. ( Arulmozhi, T; Dhanaraj, M; Rangaraj, R; Vengatesan, A, 2006) |
| "From 100 consecutive epilepsy patients we selected those with phenytoin use for more than 2 months and with MRI scan available for volumetric studies." | 3.72 | Cerebellar volume and long-term use of phenytoin. ( Cendes, F; De Marcos, FA; Ghizoni, E; Kobayashi, E; Li, LM, 2003) |
| " She had been diagnosed with idiopathic epilepsy and was given phenytoin 2 months before admission to our hospital." | 3.72 | Use of biperiden hydrochloride in a child with severe dyskinesia induced by phenytoin. ( Anlar, O; Caksen, H; Odabaş, D, 2003) |
| " The purpose of this study was to investigate the afferent fiber system to the cerebellum in patients with phenytoin (PHT)-induced cerebellar atrophy in comparison with cerebellar atrophy of other etiologies by using DT-MRI." | 3.72 | Diffusion tensor MRI and fiber tractography of cerebellar atrophy in phenytoin users. ( Chu, M; Heo, K; Kim, DI; Kim, DJ; Kim, SY; Lee, BI; Lee, SK; Mori, S, 2003) |
| "An infant who was exposed to phenytoin as monotherapy throughout pregnancy was born with the following abnormalities: midface hypoplasia, digit hypoplasia with syndactyly in the hands and feet, meningomyelocele, talipes equinovarus, and a long skin pedicle on the back." | 3.72 | Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism? ( Holmes, LB; Huang, T; Lyon, HM, 2003) |
| " Hence, the standard of care for older patients with epilepsy should be reevaluated, although the vast use of phenytoin in this population suggests that change in practice patterns may be difficult." | 3.72 | Potentially inappropriate antiepileptic drugs for elderly patients with epilepsy. ( Berlowitz, D; Charbonneau, A; Cramer, J; Kazis, L; Knoefel, J; Mandell, A; Pugh, MJ, 2004) |
| "A 19-year old man with cryptogenic simple partial and secondary generalized epilepsy developed blurred vision and xanthopsia after phenytoin loading for status epilepticus." | 3.72 | Acute visual dysfunction following phenytoin-induced toxicity. ( Deleu, D; Shenoy, R; Thakral, A, 2003) |
| " This clinical policy focuses on 6 critical questions: What laboratory tests are indicated in the otherwise healthy adult patient with a new-onset seizure who has returned to a baseline normal neurologic status?Which new-onset seizure patients who have returned to a normal baseline require a head computed tomography (CT) scan in the emergency department (ED)?Which new-onset seizure patients who have returned to normal baseline need to be admitted to the hospital and/or started on an antiepileptic drug?What are effective phenytoin or fosphenytoin dosing strategies for preventing seizure recurrence in patients who present to the ED after having had a seizure with a subtherapeutic serum phenytoin level?What agent(s) should be administered to a patient in status epilepticus who continues to seize after having received benzodiazepine and phenytoin?When should electroencephalographic (EEG) testing be performed in the ED? Recommendations for patient management are provided for each 1 of these topics on the basis of strength of evidence (Level A, B, or C)." | 3.72 | Clinical policy: Critical issues in the evaluation and management of adult patients presenting to the emergency department with seizures. ( , 2004) |
| "Phenytoin-induced gingival overgrowth is a well-known and frequently reported gingival lesion, which was first detected in 1939." | 3.72 | Phenytoin-induced gingival overgrowth in un-cooperated epilepsy patients. ( Cakmak, H; Gursoy, UK; Marakoglu, I; Marakoglu, K, 2004) |
| "The effects of phenytoin (PHT) and phenobarbital (PHB) on EEG activity and behavior was studied in the model of epilepsy induced by intracerebroventricular (i." | 3.72 | The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats. ( Stanojlovic, O; Stojanovic, J; Susic, V; Zivanovic, D, 2004) |
| "The nootropic drug piracetam was investigated in various experimental models of epilepsy." | 3.72 | Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models. ( De Sarro, G; Fischer, W; Kittner, H; Regenthal, R; Russo, E, 2004) |
| "To search for the optimal dosage of phenytoin in patients with epilepsy based on the metabolic activities of CYP2C9 and CYP2C19 polymorphisms, a total of 169 patients receiving phenytoin treatment for more than 1 month were recruited." | 3.72 | Dosage recommendation of phenytoin for patients with epilepsy with different CYP2C9/CYP2C19 polymorphisms. ( Chang, CJ; Chen, CC; Hung, CC; Lin, CJ; Liou, HH, 2004) |
| "To investigate the relationship between the genetic polymorphism of cytochrome CYP2C19 and CYP2C9 and the serum concentration of phenytoin (PHT) in patients with epilepsy." | 3.72 | [Association between genetic polymorphisms of CYP2C19 and CYP2C9 and phenytoin serum concentration]. ( Chen, B; Huang, Y; Qi, XL; Wang, WZ; Wang, YQ; Yang, JF, 2004) |
| " The boy was exposed to phenytoin, in combination with carbamazepine, during pregnancy." | 3.71 | Chondrodysplasia punctata (CDP) with features of the tibia-metacarpal type and maternal phenytoin treatment during pregnancy. ( Annerén, G; Brandberg, G; Larsson, M; Lönnerholm, T; Wester, U, 2002) |
| "We report the case of a 24-y-old woman who presented with repeated episodes of otitis due to panhypogammaglobulinemia and low levels of mature CD19 + B cells (84 cells/microl) associated with phenytoin treatment." | 3.71 | Reversible panhypogammaglobulinemia associated with phenytoin treatment. ( Pereira, LF; Sanchez, JF, 2002) |
| "To determine the effects of temperature on binding characteristics of phenytoin to serum proteins in paediatric patients with epilepsy." | 3.71 | Effect of temperature on serum protein binding characteristics of phenytoin in monotherapy paediatric patients with epilepsy. ( Itokazu, N; Kanemaru, R; Kodama, H; Kodama, Y; Shinozawa, S; Sugimoto, T, 2001) |
| "To evaluate the potential pharmacokinetic interactions between topiramate (TPM) and phenytoin (PHT) in patients with epilepsy by studying their pharmacokinetics (PK) after monotherapy and concomitant TPM/PHT treatment." | 3.71 | Topiramate and phenytoin pharmacokinetics during repetitive monotherapy and combination therapy to epileptic patients. ( Bialer, M; Bishop, FE; Curtin, CR; Doose, DR; Gisclon, LG; Kunze, KL; Levy, RH; Mather, GG; Roskos, LK; Sachdeo, RC; Sachdeo, SK; Shen, DD; Streeter, AJ; Thummel, KE; Trager, WF, 2002) |
| "To elucidate the involvement of bFGF (basic fibroblast growth factor) in the pathogenesis of phenytoin-induced gingival overgrowth, we measured the concentration of bFGF in the serum of 36 epileptic patients taking phenytoin and in 94 normal volunteers by enzyme-linked immunosorbent assay technique." | 3.70 | Increased bFGF level in the serum of patients with phenytoin-induced gingival overgrowth. ( Maita, E; Sasaki, T, 1998) |
| "To evaluate the interictal autonomic nervous system function in 84 patients with epilepsy: 37 with newly diagnosed, previously untreated epilepsy, and 47 patients receiving long-term carbamazepine (CBZ), phenytoin (PHT), or valproate (VPA) monotherapy, or CBZ plus PHT, or CBZ plus VPA for their seizure disorder." | 3.70 | Interictal cardiovascular autonomic responses in patients with epilepsy. ( Ansakorpi, H; Isojärvi, JI; Myllylä, VV; Repo, M; Suominen, K; Tolonen, U, 1998) |
| "One hundred and ninety-five (113 black and 82 coloured) compliant people with epilepsy receiving generic phenytoin monotherapy." | 3.70 | Benefits of a clinical pharmacokinetic service in optimising phenytoin use in the western Cape. ( Folb, PI; Kies, BM; Seymour, MA; Valodia, P, 1998) |
| "The last premortem serum concentrations of phenobarbital (PB), phenytoin (PHT), carbamazepine (CBZ) and its CBZ-10,11-epoxide metabolite (CE) were compared with the corresponding postmortem serum concentrations in 16 adult patients of an epilepsy centre." | 3.70 | Comparison between premortem and postmortem serum concentrations of phenobarbital, phenytoin, carbamazepine and its 10,11-epoxide metabolite in institutionalized patients with epilepsy. ( Jürgens, U; May, T; Rambeck, B; Schnabel, R, 1999) |
| "A 30-year-old man was given high doses of phenytoin together with 4 antituberculous drugs for a seizure associated with a probable brain tuberculoma." | 3.70 | [Residual cerebellar ataxia following acute phenytoin intoxication]. ( al Beladi, K; al Jumah, M; Amene, P; Awada, A, 1999) |
| "The effects of temperature on the binding kinetics of phenytoin (PHT) to serum proteins were determined in patients with epilepsy." | 3.70 | Temperature effect on serum protein binding kinetics of phenytoin in monotherapy patients with epilepsy. ( Kanemaru, R; Kodama, H; Kodama, Y; Mitsuyama, Y; Shinozawa, S; Todaka, K, 1999) |
| " We report a patient with familial hypercholesterolaemia and epilepsy in whom the introduction and subsequent discontinuation of phenytoin were associated with marked changes in the lipid response to treatment with simvastatin and atorvastatin." | 3.70 | Efficacy of statin therapy: possible effect of phenytoin. ( Dominiczak, MH; Murphy, MJ, 1999) |
| "The potential effect of co-medication with phenobarbitone, primidone and carbamazepine on plasma and saliva concentrations of 5-(4-hydroxyphenyl)-5-phenylhydantoin (4-HPPH), the major metabolite of phenytoin in man and on the incidence of phenytoin-induced gingival overgrowth was investigated in a group of 36 adult epileptic patients." | 3.70 | The effect of multiple anticonvulsant therapy on the expression of phenytoin-induced gingival overgrowth. ( Ball, DE; Kamali, F; McLaughlin, WS; Seymour, RA, 1999) |
| " In PHT nonresponders, TPM significantly increased ADT, which is in line with its proven efficacy in patients with refractory partial epilepsy in whom phenytoin has failed." | 3.70 | Anticonvulsant efficacy of topiramate in phenytoin-resistant kindled rats. ( Ebert, U; Löscher, W; Reissmüller, E, 2000) |
| "Our data indicate that not only fasting but also 6h-PML tHcy levels should be determined in order to identify hyperhomocysteinemia among patients on AEDs." | 3.70 | Homocysteine concentrations and methionine loading in patients on antiepileptic drugs. ( Apeland, T; Kristensen, O; Mansoor, MA; Strandjord, RE, 2000) |
| "The chronic treatment with phenytoin or the acute intoxication by this drug may cause permanent cerebellar injury with atrophy of cerebellum vermis and hemispheres, which can be detected by neuroimaging studies." | 3.70 | [Dose-dependent relationship of chronic use of phenytoin and cerebellar atrophy in patients with epilepsy]. ( Cendes, F; Dantas, CD; Del Negro, A; Montenegro, MA; Zanardi, V, 2000) |
| "The aim of the present study was to determine the gender-related binding characteristics of phenytoin (PHT) to serum proteins in adult patients with epilepsy." | 3.70 | No gender effect on binding characteristics of phenytoin to serum proteins in monotherapy for adult patients with epilepsy. ( Kanemaru, R; Kodama, H; Kodama, Y; Mitsuyama, Y; Shinozawa, S; Todaka, K, 2000) |
| "We evaluated the effects of carbamazepine (CBZ) on serum androgen levels and sexual function prospectively for 5 years in 11 men with epilepsy and in 25 patients receiving either CBZ (14 patients) or phenytoin (PHT) (11) monotherapy for > 5 years." | 3.69 | Carbamazepine, phenytoin, sex hormones, and sexual function in men with epilepsy. ( Isojärvi, JI; Lukkarinen, O; Myllylä, VV; Pakarinen, AJ; Repo, M, 1995) |
| "Urinary excretions of carbamazepine, carbamazepine-10,11-epoxide, carbamazepine-10,11-trans-diol, 9-hydroxyacridan and 2- and 3-hydroxycarbamazepine were measured at various stages of pregnancy, and in the post-natal period, in ten epileptic women, six of whom took no other enzyme-inducing anticonvulsant and four of whom took such co-medication." | 3.69 | Metabolism of carbamazepine and co-administered anticonvulsants during pregnancy. ( Bernus, I; Dickinson, RG; Eadie, MJ; Hooper, WD, 1995) |
| "Cerebellar atrophy has been noted in patients with phenytoin exposure." | 3.69 | Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy. ( Barr, WB; Lantos, G; Ney, GC; Schaul, N, 1994) |
| "Phenytoin serum concentrations were evaluated in 88 epileptic women at different stages of pregnancy and 40 women during postnatal periods." | 3.69 | Phenytoin serum concentration monitoring during pregnancy and puerperium in Mexican epileptic women. ( Amancio-Chassin, O; Belmont-Gómez, A; Estrada-Altamirano, A; Hernández-Serrano, M; Herrerías-Cunedo, T; Rodríguez-Palomares, C, 1995) |
| "To evaluate the population pharmacokinetics of valproic acid in children, 97 steady-state serum valproate concentration measurements were gathered during normal, routine, outpatient care of 52 children with epilepsy (1." | 3.69 | A model for estimating individualized valproate clearance values in children. ( Botha, JH; Gray, AL; Miller, R, 1995) |
| " We studied the pharmacokinetic and pharmacodynamic aspects of an oral 15-mg dose of midazolam in 6 patients with epilepsy who are also taking carbamazepine (CBZ) or phenytoin (PHT)." | 3.69 | Concentrations and effects of oral midazolam are greatly reduced in patients treated with carbamazepine or phenytoin. ( Backman, JT; Laaksovirta, H; Neuvonen, PJ; Ojala, M; Olkkola, KT, 1996) |
| "Topiramate, a structurally novel anticonvulsant, and phenytoin were evaluated in a rat model of ischemia-induced epilepsy." | 3.69 | Anticonvulsant activity of topiramate and phenytoin in a rat model of ischemia-induced epilepsy. ( Edmonds, HL; Jiang, YD; Shank, RP; Zhang, PY, 1996) |
| "The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36." | 3.69 | Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996) |
| "The cobalt model of epilepsy, in combination with the C-14 2-deoxyglucose (2-DG) autoradiographic technique, was used to assess the effects of phenytoin (PHT) and ethosuximide (ESM), two antiepileptic drugs, and ketamine (KET), a drug with anticonvulsant properties, on brain activity." | 3.69 | A combined cobalt and C-14 2-deoxyglucose approach to antiepileptic drug assessment. ( Cooper, RM; Krenz, NR, 1996) |
| "We examined the effect of CYP2C9/19 polymorphisms on the pharmacokinetics of phenytoin in 17 Japanese patients with epilepsy." | 3.69 | Effect of CYP2C polymorphisms on the pharmacokinetics of phenytoin in Japanese patients with epilepsy. ( Furusho, K; Hashimoto, Y; Hattori, H; Iui, K; Odani, A; Otsuki, Y; Takano, M, 1996) |
| " Available history is that he is a 20-year-old student with well-controlled epilepsy for which he takes phenytoin." | 3.69 | Drugs and brain death. ( Chivell, W; Fearnside, M; Kennedy, MC; Moran, JL; Morris, RG; Tobin, B; Upton, RN, 1996) |
| "We report the first case of Epstein Barr virus (EBV) positive non-Hodgkin's lymphoma occurring 20 years after continuous phenytoin therapy for idiopathic epilepsy." | 3.69 | EBV-positive non-Hodgkin's lymphoma developing after phenytoin therapy. ( Del Campo, F; Dominguez-Franjo, P; Garcia-Suarez, J; Herrero, B; Munoz, MA; Pardo, A; Piris, MA, 1996) |
| "Twelve patients with epilepsy receiving chronic phenytoin therapy and 12 healthy control subjects matched for age and gender received a single oral dose of nisoldipine (40 and 20 mg, respectively)." | 3.69 | Reduced plasma nisoldipine concentrations in phenytoin-treated patients with epilepsy. ( Cipolla, G; Gatti, G; Heinig, R; Michelucci, R; Ochan, M; Passarelli, D; Perucca, E; Tassinari, CA, 1996) |
| "We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures." | 3.69 | Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1997) |
| " Eighty patients presenting with epilepsy received monotherapies of valproic acid, phenytoin, or carbamazepine; 18 patients did not receive antiepileptic drug therapy." | 3.69 | Color vision tests for early detection of antiepileptic drug toxicity. ( Bayer, AU; Dichgans, J; Kuehn, M; Paulus, W; Ried, S; Schmidt, D; Thiel, HJ; Zrenner, E, 1997) |
| "We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy." | 3.69 | BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. ( Morimoto, K; Sato, H; Sato, K; Sato, S; Yamada, N, 1997) |
| " We studied the changes in arrhythmia profile and heart-rate variability, during abrupt withdrawal of carbamazepine and phenytoin treatment in 10 patients with side effects on these drugs." | 3.69 | Changes in arrhythmia profile and heart rate variability during abrupt withdrawal of antiepileptic drugs. Implications for sudden death. ( Bergfeldt, L; Ericson, M; Kennebäck, G; Tomson, T, 1997) |
| "The possibility that vigabatrin (VGB) decreases serum phenytoin (PHT) concentration by lowering the oral bioavailability of PHT was investigated in 21 patients with epilepsy." | 3.68 | Vigabatrin-induced decrease in serum phenytoin concentration does not involve a change in phenytoin bioavailability. ( Bartoli, A; Gatti, G; Marchiselli, R; Michelucci, R; Perucca, E; Pisani, F; Richens, A; Tassinari, CA; Timmings, P; Zaccara, G, 1993) |
| "Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline." | 3.68 | Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993) |
| "The anticonvulsant activity of U-54494A was studied in a 4-aminopyridine (4-AP) epilepsy model using extracellular recordings in in vitro hippocampal slices." | 3.68 | U-54494A reduces 4-AP-induced afterdischarges of CA1 pyramidal cells in the hippocampal slice of the rat. ( Camacho-Ochoa, M; Hoffmann, WE; Piercey, MP; VonVoigtlander, PF, 1992) |
| "This investigation examines the incidence of phenytoin-induced gingival overgrowth in a population of epileptic patients who attend General Medical Practices for treatment of their epilepsy and compares the gingival changes with an otherwise healthy group of patients." | 3.68 | Incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients in general medical practice. ( Rawlins, MD; Seymour, RA; Thomason, JM, 1992) |
| "The steady-state 72 h urinary excretion of various phenytoin metabolites has been measured in 10 epileptic women, whose plasma phenytoin concentrations relative to the phenytoin dose fell during pregnancy and rose again post-partum." | 3.68 | Phenytoin metabolism during pregnancy. ( Dickinson, RG; Eadie, MJ; Hooper, WD; Lander, CM; McKinnon, GE, 1992) |
| "We retrospectively collected plasma level assessments performed in 96 adult patients with epilepsy on stable monotherapy, including 9 patients on clobazam (CLB), 34 on carbamazepine (CBZ), 24 on phenobarbital (PB), 9 on phenytoin (PHT), and 20 on valproate (VPA); these results were compared to those obtained in 54 adult patients on stable bitherapy with the association of CLB with either CBZ (n = 17), PB (n = 17), PHT (n = 5), or VPA (n = 15)." | 3.68 | Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy. ( Bonneton, J; Dravet, C; Genton, P; Mesdjian, E; Roger, J; Sennoune, S, 1992) |
| "A single case of IgA nephropathy with a concomitant tubulointerstitial nephritis, developing during a long-term phenytoin therapy is reported." | 3.68 | [Long-term phenytoin (Diphedan) therapy leading to IgA nephropathy]. ( Deák, G; Háber, A; Nagy, J; Süle, T, 1992) |
| "We report the case of a young man suffering from epilepsy who developed chronic calcified pancreatitis after ten years of therapy with the anticonvulsant drugs carbamazepine and phenytoin." | 3.68 | Anticonvulsant-induced chronic pancreatitis. A case report. ( Billi, P; Broccoli, PL; Fontana, G; Melandri, R; Pezzilli, R, 1992) |
| " We report here the occurrence of crusted scabies in a 40-year-old man with acquired selective IgA deficiency suspected to be caused by long-term medication with phenytoin for epilepsy." | 3.68 | Crusted scabies in acquired selective IgA deficiency. ( Hamada, T; Kitajima, J; Kono, T; Shindo, K, 1991) |
| "We report the cases of four patients who were taking the anticonvulsant drugs phenytoin or carbamazepine and in whom skin lesions developed that showed histologic features suggestive of mycosis fungoides." | 3.68 | Mycosis fungoides-like lesions associated with phenytoin and carbamazepine therapy. ( Kruyswijk, MR; Meijer, CJ; Rijlaarsdam, U; Scheffer, E; Willemze, R, 1991) |
| "In newly diagnosed adult patients with epilepsy followed prospectively on monotherapy, carbamazepine and phenytoin were associated with a fall in plasma uric acid, but sodium valproate and phenobarbitone were associated with a rise in plasma uric acid." | 3.68 | Plasma uric acid in patients receiving anticonvulsant monotherapy. ( Heller, AJ; Johnson, AL; Marshall, WJ; Reynolds, EH; Ring, HA, 1991) |
| "The effects of antiepileptic drugs (AED) on infants during pregnancy and delivery were studied in a total of 82 epileptic mothers on various monotherapies; 29 cases receiving valproic acid (VPA), 20 receiving phenytoin (PHT), 18 on carbamazepine (CBZ) and 15 on phenobarbital (PB)." | 3.68 | [Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital]. ( Ishikawa, S; Izumi, M; Okada, H; Takeda, A; Tanaka, H, 1991) |
| "Methsuximide was added to the therapeutic regimens of 25 children with intractable epilepsy." | 3.68 | Methsuximide for intractable childhood seizures. ( Greenwood, RS; Miles, MV; Tennison, MB, 1991) |
| "The case of a mentally handicapped female patient is presented who developed typical pellagra with dermatitis, diarrhoea and mental alteration following a long-term antiepileptic treatment with phenytoin, ethosuximide and valproic acid." | 3.68 | [Pellagra in anticonvulsive therapy]. ( Bartels, H; Hebestreit, H; Mingers, AM; Pannenbecker, J, 1990) |
| " This is a syndrome of idiopathic generalized epilepsy that responds to treatment with valproic acid." | 3.68 | Eyelid twitching seizures and generalized tonic-clonic convulsions: a syndrome of idiopathic generalized epilepsy. ( Ferrendelli, JA; Miller, JW, 1990) |
| "Free and total carbamazepine (CBZ) and carbamazepine-epoxide (CBZ-EP) plasma levels were obtained on 113 patients with epilepsy (18-61 years old) controlled on either monotherapy or coadministration with either phenobarbital (PB), phenytoin (PHT), valproic acid (VPA), or all three." | 3.68 | Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy. ( Briggle, TV; Guterman, A; McManus, DQ; Perchalski, R; Ramsay, RE; Vazquez, D; Wong, P; Yost, RA, 1990) |
| "39 adult patients with intractable epilepsy were successfully treated with high-dose monotherapy, using carbamazepine or phenytoin." | 3.68 | [High-dose monotherapy in intractable epilepsy]. ( Peng, SM; Wu, JZ, 1990) |
| "An infant with dysmorphic features was born to an epileptic mother who had taken phenytoin and sodium valproate throughout pregnancy." | 3.68 | Neocerebellar hypoplasia in a neonate following intra-uterine exposure to anticonvulsants. ( Hope, PL; Lindenbaum, RH; Squier, W, 1990) |
| "A man developed acne keloidalis-like lesions in the scalp during treatment with diphenylhydantoin and carbamazepine for epilepsy." | 3.68 | Acne keloidalis-like lesions on the scalp associated with antiepileptic drugs. ( Ben-Dor, D; Grunwald, MH; Halevy, S; Livni, E, 1990) |
| " Fifty-two children had been exposed to phenytoin monotherapy, 19 to carbamazepine monotherapy, 27 to drug combinations including barbiturates, 29 to other drug combinations, and 17 children had not been exposed to antiepileptic drugs (AEDs) during pregnancy." | 3.68 | Head circumference in children of epileptic mothers: contributions of drug exposure and genetic background. ( Bardy, AH; Gaily, EK; Granström, ML; Hiilesmaa, VK, 1990) |
| "Serum concentrations of the main vitamin D metabolites and of calcium, phosphate, and alkaline phosphatase were determined in each of the three trimesters of pregnancy and in simultaneously obtained maternal and cord blood at delivery in 22 epileptic women treated with diphenylhydantoin or carbamazepine alone or with a combination with one other drug." | 3.67 | Anticonvulsant drug therapy in human pregnancy: effects on serum concentrations of vitamin D metabolites in maternal and cord blood. ( Aarskog, D; Aksnes, L; Markestad, T; Strandjord, RE; Ulstein, M, 1984) |
| "To evaluate the effect of anticonvulsants on serum levels of free thyroxine (FT4) and thyroxine-binding globulin (TBG), 32 patients with epilepsy receiving long-term anticonvulsant treatment (mean duration 81." | 3.67 | Lowering effect of diphenylhydantoin on serum free thyroxine and thyroxine binding globulin (TBG). ( Hiraiwa, M; Miyasaka, M; Mori, K; Shimoda, S; Suzuki, H; Suzuki, Y; Yamazaki, N, 1984) |
| "Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug." | 3.67 | Bioavailability and pharmacokinetics of phenytoin during pregnancy. ( Chalk, JB; de Wytt, C; Eadie, MJ; Lander, CM; Livingstone, I; Smith, MT; Symoniw, P, 1984) |
| "We evaluated the therapeutic efficacy and toxicity of high-dose monotherapy, using carbamazepine or phenytoin, in patients with previously uncontrolled seizures." | 3.67 | High-dose monotherapy in treatment of intractable seizures. ( Dinner, DS; Lesser, RP; Lüders, H; Pippenger, CE, 1984) |
| "Chromosome studies were carried out on the peripheral blood of 26 epilepsy patients treated with phenobarbital and/or diphenylhydantoin, on ten healthy controls and on eight untreated epileptic controls." | 3.67 | Chromosomal studies of peripheral blood from epileptic patients treated with phenobarbital and/or diphenylhydantoin. ( Ambani, LM; Kulkarni, PS; Mondkar, VP; Sonawalla, AB, 1984) |
| "In a cross-sectional, epidemiological study of phenytoin induced gingival overgrowth in 77 institutionalized persons with epilepsy, the severity of the gum lesions was quantified by means of a precise new technique." | 3.67 | Phenytoin induced gingival overgrowth in institutionalized epileptics. ( Best, H; Hassell, T; Murphy, T; O'Donnell, J; Pearlman, J; Tesini, D, 1984) |
| "A patient with epilepsy and psoriasis in phenytoin therapy was treated with PUVA with no effect at all." | 3.67 | Interaction between 8-methoxypsoralen and phenytoin. Consequence for PUVA therapy. ( Hueg, B; Staberg, B, 1985) |
| "The peripheral blood lymphocytes, serum immunoglobulins, C3 and C4 complement protein concentrations of 20 patients with idiopathic epilepsy who were receiving phenytoin were examined and compared with 30 healthy controls in order to obtain a detailed profile of the effects of the drug on the humoral and cellular immune systems." | 3.67 | Serum immunoglobulins, complement levels and lymphocyte subpopulations in phenytoin-treated epileptic patients. ( Başaran, N; Hincal, F; Kansu, E, 1989) |
| "The estimation of Michaelis-Menten pharmacokinetic parameters in patients with epilepsy receiving phenytoin continues to be a vexing problem." | 3.67 | Determination of enzyme or binding constants using generalized linear models, with particular reference to Michaelis-Menten models. ( Friel, P; Guo, SW; Leurgans, S; van Belle, G; Yerby, M, 1989) |
| " Statistical analyses showed that group 2 had a longer history of epilepsy with a consequently longer duration of phenytoin (PHT) consumption." | 3.67 | Role of the cerebellum in complex human behavior. ( Attig, E; Botez, MI; Botez, T; Elie, R, 1989) |
| "We have identified ten children who developed gastritis after prolonged anticonvulsant therapy that included either valproic acid or divalproex sodium." | 3.67 | Gastritis with valproate therapy. ( Bobele, GB; Bodensteiner, JB; Grunow, JE; Hille, MR; Marks, WA; Morris, MP; Tuggle, D, 1988) |
| "A 26-year-old woman, treated with phenytoin for 10 years because of epilepsy, had Norplant subdermal implants inserted after a legal abortion." | 3.67 | Enhanced metabolism of levonorgestrel during phenytoin treatment in a woman with Norplant implants. ( Odlind, V; Olsson, SE, 1986) |
| "To assess the most efficient means of monitoring thyroid status in an epilepsy clinic, total thyroxine (T4), free thyroxine stimulating hormone (TSH) were measured in 71 adult patients treated long-term with either phenytoin (DPH), carbamazepine (CBZ) or sodium valproate (VAL)." | 3.67 | The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic. ( Borsey, DQ; Browning, MC; Connacher, AA; Davidson, DL; Jung, RT, 1987) |
| "In a survey of the red cell folate status of 200 patients with epilepsy, compared to 72 controls, we found that median red cell folate levels were reduced significantly in patients treated with phenytoin (p less than 0." | 3.67 | A comparative study of the relative effects of anticonvulsant drugs and dietary folate on the red cell folate status of patients with epilepsy. ( Baker, M; Bissessar, A; Callaghan, N; Crowley, M; Goggin, T; Gough, H, 1987) |
| "The Comprehensive Epilepsy Program of Minnesota database was searched for patients who had no dose change of carbamazepine (CBZ), phenytoin (PHT) or valproate (VPA) for 3 consecutive visits." | 3.67 | Variability of phenytoin, carbamazepine and valproate concentrations in a clinic population. ( Leppik, IE, 1988) |
| "The need for careful monitoring of plasma concentrations of phenytoin during use of the drug in the treatment of epilepsy is well recognized; there can be great intersubject variation in the absorption rate and clearance rate of the drug, and its therapeutic ratio is narrow." | 3.67 | Comparative determination of phenytoin in plasma by fluorescence polarization immunoassay and high performance liquid chromatography. ( al-Turk, WA; Awidi, AS; Daradkeh, TK; Othman, S; Shaheen, O, 1987) |
| " Of the study group, 106 children had been exposed to antiepileptic drugs (82 to phenytoin) during pregnancy; 44 (36%) mothers had had generalized convulsions during pregnancy." | 3.67 | Minor anomalies in offspring of epileptic mothers. ( Bardy, A; Gaily, E; Granström, ML; Hiilesmaa, V, 1988) |
| "In the routine care of 37 patients at the epilepsy outpatient clinic of Baragwanath Hospital, Johannesburg, 100 steady-state serum phenytoin concentrations were measured." | 3.67 | Population pharmacokinetics of phenytoin in South African black patients. ( Klein, C; Miller, R; Rheeders, M; Suchet, I, 1987) |
| "We report the occurrence of bilateral cataracts in a young adult which developed shortly after documented high serum levels of phenytoin." | 3.67 | Development of presenile cataracts in association with high serum levels of phenytoin. ( Earll, J; Kattan, H; Lemp, M; Mathers, W, 1987) |
| " Their psychiatric interest stems from evidence of an inhibiting effect of certain substances, such as carbamazepine or phenytoin, which are effective in the treatment of both epilepsy and mental disorders, but this effect is also found for lithium (Post et al." | 3.67 | Kindling models and antikindling effects of mood normalizers. ( Azorin, JM; Tramoni, V, 1987) |
| "Report on a prospective longitudinal study of alterations in polygraphic sleep by phenytoin monotherapy for epilepsy." | 3.67 | Response of polygraphic sleep to phenytoin treatment for epilepsy. A longitudinal study of immediate, short- and long-term effects. ( Noachtar, S; Röder-Wanner, UU; Wolf, P, 1987) |
| "The incidence of grand mal seizures, distribution of drug levels relative to the therapeutic range and the incidence of side effects were monitored before and after the provision of same-day preconsultation assay results (phenytoin and carbamazepine) to an epilepsy clinic." | 3.67 | Availability of drug assay results and dosage advice improves antiepileptic care in a specialist neurology outpatient clinic. ( Gilligan, BS; Harrison, PM; Heinzow, U; Horne, M; Ioannides-Demos, LL; McLean, AJ; Tong, N; Wodak, J, 1985) |
| "After treatment with valproic acid a 19-year-old female patient with Friedreich's ataxia and generalised epilepsy died following acute hepatic failure with massive lactacidosis." | 3.67 | [Acute liver necrosis caused by valproate]. ( Hackenberg, K; Rengeling, M; Rühl, G; Zäh, W, 1985) |
| "Steady-state serum concentrations of phenytoin and phenobarbital were obtained in 70 epileptic patients in Taiwan and evaluated with respect to age, sex, and body weight." | 3.67 | Steady-state serum levels of anticonvulsant drugs in Chinese epileptic patients living in Taiwan. ( Lai, ML, 1985) |
| "Reversible chronic cerebellar ataxia followed phenytoin treatment in two epileptic women." | 3.67 | Reversible chronic cerebellar ataxia after phenytoin intoxication: possible role of cerebellum in cognitive thought. ( Attig, E; Botez, MI; Gravel, J; Vézina, JL, 1985) |
| "Among 50 patients with phenytoin intoxication, 14 had seizures during the episode." | 3.67 | Incidence of seizures with phenytoin toxicity. ( Masdeu, JC; Stilman, N, 1985) |
| "Phenytoin has been shown to induce serum IgA deficiency in patients with epilepsy." | 3.66 | The reversibility of phenytoin-induced IgA deficiency. ( Aarli, JA; Gilhus, NE, 1981) |
| "A total of 20 children with various types of epilepsy were treated with valproate, 11 with monotherapy and 9 with valproate in combination with phenobarbitone, phenytoin, or carbamazepine." | 3.66 | Plasma concentrations of valproate during maintenance therapy in epileptic children. ( Boréus, LO; Lundberg, B; Nergårdh, A, 1982) |
| "The effects of delta 9-tetrahydrocannabinol (delta 9-THC), two of its metabolites, 8 beta-hydroxy-delta 9-THC and 11-hydroxy-delta 9-THC, and cannabidiol were comparatively studied by means of an iron-induced cortical focal epilepsy in conscious rats with chronically implanted electrodes." | 3.66 | Central excitatory properties of delta 9-tetrahydrocannabinol and its metabolites in iron-induced epileptic rats. ( Karler, R; Turkanis, SA, 1982) |
| "Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered." | 3.66 | Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports. ( Arena, R; Bindi, A; Bonuccelli, U; De Scisciolo, G; Marcacci, G; Rossi, L, 1983) |
| "The problem of phenytoin-induced gingival hyperplasia is dicussed within the context of consultative planning between oral care practitioners and the physician managing the epilepsy." | 3.66 | Therapeutic alternatives in phenytoin-induced gingival hyperplasia. A case report and discussion. ( Kirkham, DB; Reynolds, NC, 1980) |
| "Sodium valproate is often used with phenytoin when epilepsy cannot be controlled by a single drug." | 3.66 | Phenytoin-valproate interaction: importance of saliva monitoring in epilepsy. ( Hamshaw-Thomas, A; Knott, C; Reynolds, F, 1982) |
| "In 12 institutionalized epilepsy patients who had been treated 19 months (SD +/- 5) with valproic acid, 27." | 3.66 | Serial free and plasma valproic acid and phenytoin monitoring and drug interactions. ( Haidukewych, D; Rodin, EA, 1981) |
| "The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)." | 3.66 | Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982) |
| "Clinical and experimental studies were performed on the mechanisms of metabolic acidosis observed in the children with epilepsy who had long been treated with anticonvulsants such as phenobarbital (PB) or diphenylhydantoin (DPH)." | 3.66 | [Studies on the mechanism of metabolic acidosis observed in the children treated with anticonvulsants]. ( Nagai, B, 1982) |
| "Cataracts developed in two young adults who were receiving prolonged antiepileptic treatment with phenobarbital sodium and phenytoin sodium." | 3.66 | Presenile cataracts in phenytoin-treated epileptic patients. ( Bar, S; Feller, N; Savir, H, 1983) |
| " In severely jaundiced patients (serum bilirubin concentrations greater than 140 mumol/l) a markedly decreased or absent uptake of 99mTc-EHIDA was observed." | 3.66 | The influence of bilirubin, alcohol and certain drugs on the kinetics of 99mTc-Diethyl IDA (EHIDA) in humans. ( Coenegracht, JM; Oei, TL; van Breda Vriesman, PJ, 1983) |
| "Analysis of plasma phenytoin in a group of patients treated for epilepsy showed that only 36% had values in the therapeutic range." | 3.66 | Prediction of phenytoin dosage in epilepsy using multiple linear regression. ( Gray, SP, 1982) |
| "The effect of phenytoin (PHT) on the metabolism of zinc (Zn) and copper (Cu) has been studied during treatment for epilepsy." | 3.66 | Zinc and copper metabolism in phenytoin therapy. ( Hallmans, G; Palm, R, 1982) |
| " Using accepted CT criteria for the diagnosis of cerebellar atrophy, the films were analyzed in a blind, unbiased fashion to evaluate possible relationship between cerebellar atrophy and phenytoin use or epilepsy itself." | 3.66 | Cerebellar atrophy in epilepsy and headache: lack of relationship to phenytoin. ( Ballenger, CE; Brooks, BS; El Gammal, T; Green, JB; King, DW; Lucke, JF, 1982) |
| "A 5-year-old child with epilepsy and underlying brain damage developed choreo-athetosis during intoxication with phenytoin." | 3.66 | Choreo-athetosis induced by phenytoin in an epileptic child. A case report. ( Sandyk, R, 1981) |
| "The folic acid absorption test (FAAT) has carried out in 18 normal control subjects; 8 patients with proven atrophy of the jejunal mucosa; 7 patients with gastric ulcus; 17 patients with reactive hypoglycemia; 13 patients with diabetes mellitus, and, finally, 9 epileptic patients treated with diphenylhydantoin (DPH)." | 3.66 | Folic acid absorption test in various clinical conditions. ( Bachevalier, J; Botez, MI, 1981) |
| "1 Patients with poorly controlled epilepsy were cautiously transferred from multiple drug therapy to treatment with phenytoin sodium alone." | 3.66 | Serum phenytoin concentration and clinical response in patients with epilepsy. ( Gannaway, DJ; Mawer, GE, 1981) |
| "We describe a procedure for determining 2-ethyl-2-phenylmalonamide (I) in serum of epilepsy patients dosed with primidone (II) for seizure control, by extracting the sample with chloroform under basic conditions, with use of an internal standard, 2-ethyl-2-(p-tolyl)malonamide, and without derivative formation." | 3.66 | Monitoring 2-ethyl-2-phenylmalonamide in serum by gas-liquid chromatography: application to retrospective study in epilepsy patients dosed with primidone. ( Haidukewych, D; Rodin, EA, 1980) |
| "Nine cases of childhood epilepsy manifesting motor convulsions uncontrolled despite high levels of phenytoin (PHT) were studied clinically and electroencephalographically." | 3.66 | Childhood epilepsy uncontrolled by phenytoin: clinical and electroencephalographic study. ( Iinuma, K; Onuma, A; Tada, K; Takamatsu, N, 1979) |
| "Gingival hyperplasia caused by phenytoin sodium is rarely encountered in edentulous persons." | 3.66 | Diphenylhydantoinate-induced hyperplasia of the masticatory mucosa in an edentulous epileptic patient. ( Dreyer, WP; Thomas, CJ, 1978) |
| "Blood levels of phenytoin, total thyroxine, and free thyroxine were determined in 10 epileptic women during and following pregnancy." | 3.66 | Epilepsy and pregnancy. Serum thyroxine levels during phenytoin therapy. ( Ramsay, RE; Spellacy, WN; Strauss, RG; Wilder, BJ; Willmore, LJ, 1979) |
| " The treatment of status epilepticus with intravenous phenytoin is effective." | 3.66 | Epilepsy and pregnancy. ( Bruni, J; Willmore, LJ, 1979) |
| "The effect of long-term phenytoin therapy on serum triglyceride and cholesterol levels in 20 patients with epilepsy was investigated." | 3.66 | Changes in serum triglyceride and cholesterol levels during long-term phenytoin treatment for epilepsy. ( Luoma, PV; Reunanen, MI; Sotaniemi, EA, 1979) |
| " Antipyrine t1/2 did not distinguish epileptics with osteomalacia from other epileptic patients and half-lives were similar in patients treated with phenytoin and a barbiturate to those in patients on phenytoin alone." | 3.66 | Antiopyrine half-life as a measure of hepatic enzyme induction: clinical applications in a chronic epileptic population. ( Byrne, E; Frewin, DB; Hallpike, JF; Harman, AW, 1979) |
| "Birth defects associated with phenytoin and phenobarbital taken during pregnancy include craniofacial and limb deformities." | 3.66 | Fetal hydantoin syndrome in triplets. A unique experiment of nature. ( Bustamante, SA; Stumpff, LC, 1978) |
| ", raise the possibility that fetal damage previously attributed to phenytoin and other anticonvulsant drugs, principally phenobarbitone, may be due to epilepsy itself." | 3.65 | Anticonvulsants and parental epilepsy in the development of birth defects. ( Hartz, SC; Heinonen, OP; Mitchell, AA; Monson, RR; Rosenberg, L; Shapiro, S; Siskind, V; Slone, D, 1976) |
| "The therapeutics results with the use of different drugs (diazepam, nitrazepam, clonazepam, diphenylhydantoin, barbiturates--phenobarbital and primidone--, sodium dipropylacetate and ACTH) in twenty-nine patients with Lennox--Gastaut syndrome are carefully analysed." | 3.65 | [Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome]. ( Lison, MP; Speciali, GG, 1977) |
| "Plasma anticonvulsant levels were followed during pregnancy in 11 epileptic women taking phenytoin and/or phenobarbital or a drug metabolized in the body to phenobarbital." | 3.65 | Plasma anticonvulsant concentrations during pregnancy. ( Eadie, MJ; Edwards, VE; Lander, CM; Tyrer, JH, 1977) |
| "Malignant mesenchymoma developed in an 18-year-old patient with phenytoin-associated cleft lip and palate." | 3.65 | Malignant mesenchymoma and birth defects. Prenatal exposure to phenytoin. ( Blattner, WA; Fraumeni, JF; Henson, DE; Young, RC, 1977) |
| "A 49-year-old female with chronic alcoholism and epilepsy, treated with phenytoin, began to convulse when treatment with disulfiram (an inhibitor of phenytoin metabolism) was discontinued." | 3.65 | Multiple drug interactions with phenytoin. ( Birkett, DJ; Chinwah, PM; Graham, GG; Hickie, JB; Wade, DN, 1977) |
| " In the Hungarian Congenital Malformation Register use of the anticonvulsants diazepam and phenobarbiturates during pregnancy was determined in infants delivered with cleft lip with or without cleft palate, posterior cleft palate and, as a control, anencephaly and spina bifida." | 3.65 | A teratological evaluation of anticonvulsant drugs. ( Czeizel, E; Lakos, P, 1977) |
| "The effect of toxic and non-toxic phenytoin levels on carobhydrate tolerance and insulin levels was studied in 18 patients with epilepsy and 17 control subjects." | 3.65 | The effects of toxic and non-toxic serum phenytoin levels on carbohydrate tolerance and insulin levels. ( Callaghan, N; Cramer, B; Duggan, B; Feely, M; McGarry, J; O'Callaghan, M; Seldrup, J; Wheelan, J, 1977) |
| "Cerebellar changes have been reported in relationship to epilepsy alone as well as to phenytoin therapy for the control of seizures." | 3.65 | Phenytoin-related cerebellar degeneration without seizures. ( Rapport, RL; Shaw, CM, 1977) |
| "Cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and probenecid were examined in 14 children with epilepsy (ages 6 months to 17 years) and 17 controls (ages 14 months to 16 years)." | 3.65 | Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. ( Bowers, MB; Cohen, DJ; Shaywitz, BA, 1975) |
| "In vitro and in vivo immunologic studies were performed on a 28-year-old woman with phenytoin sodium-induced pseudolymphoma syndrome." | 3.65 | Phenytoin-induced pseudolymphoma syndrome: an immunologic study. ( Charlesworth, EN, 1977) |
| "The influence of clonazepam on steady-state serum levels of diphenylhydantoin, phenobarbital and carbamazepine was studied in 22 patients with epilepsy receiving one or two of these drugs." | 3.65 | Lack of effect of clonazepam on serum levels of diphenylhydantoin, phenobarbital and carbamazepine. ( Johannessen, SI; Munthe-Kaas, AW; Strandjord, RE, 1977) |
| "Severe osteomalacia was present in two epileptic patients who were under long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide." | 3.65 | Acetazolamide-accelerated anticonvulsant osteomalacia. ( Mallette, LE, 1977) |
| "The relationship among the serum concentration of phenytoin, pneumoencephalographic measurements describing, in particular, cerebellar atrophy, and various other clinical variables was analyzed statistically in a series of 131 phenytoin-treated mentally retarded epileptics." | 3.65 | Cerebellar atrophy in phenytoin-treated mentally retarded epileptics. ( Helle, EP; Iivanainen, M; Viukari, M, 1977) |
| " Thirteen ambulant patients suffering from partial epilepsy with complex symptomatology, who were already being treated with phenytoin in optimal doses (plasma level 14-20 mug/ml) were also given carbamazepine." | 3.65 | Plasma levels of carbamazepine and carbamazepine-10,11-epoxide during treatment of epilepsy. ( Bertilsson, L; Eichelbaum, M; Lund, L; Palmér, L; Sjöqvist, F, 1976) |
| "In the CSF's from 13 out of 30 phenytoin-treated patients the IgG concentrations were lower than the lowest amont 20 controls, while only 3 out of 37 patients with brain lesions without epilepsy had so low IgG value." | 3.65 | Reduced CSF IgG in patients treated with phenytoin (diphenylhydantoin). ( Fossan, GO, 1976) |
| "The influence of tolbutamide administration on the plasma concentrations of diphenylhydantoin (DPH) was investigated in seventeen long-stay patients with epilepsy." | 3.65 | Interaction of diphenylhydantoin (DPH) and tolbutamide in man. ( Mols-Thürkow, I; Wesseling, H, 1975) |
| "Two patients with intractable epilepsy who had been treated with various combinations of anticonvulsant drugs developed phenytoin encephalopathy." | 3.65 | Choreo-athetosis and encephalopathy induced by phenytoin. ( McLellan, DL; Swash, M, 1974) |
| "Various immunological features were measured in 20 patients with epilepsy who had received prolonged treatment with hydantoins." | 3.65 | Immunological abnormalities and hydantoins. ( Grob, PJ; Herold, GE, 1972) |
| "Serum phenytoin concentrations in outpatients and inpatients with epilepsy have been contrasted." | 3.65 | Supervision of epileptic patients taking phenytoin. ( Dunne, JF; Gibberd, FB; Handley, AJ; Hazleman, BL, 1970) |
| " Phenobarbital is usually given as well to prevent grand mal seizures." | 3.64 | Treatment of epilepsy. ( BAILEY, AA, 1963) |
| "Phenytoin is a prototypic drug prescribed for the treatment of a variety of seizure disorders." | 3.01 | Cutaneous Hypersensitivity Reaction After Phenytoin Therapy in a Neonate: A Case Report and Review of Literature Elucidating the Potential Pharmacological Plausibility and Preventive Strategies. ( Prabath, I; Rajendran, P; Rani, J, 2023) |
| "Epilepsy is an important cause of morbidity and mortality especially in low- and middle-income countries." | 3.01 | Challenges in epilepsy diagnosis and management in a low-resource setting: An experience from Bhutan. ( Chhetri, B; Dhakal, GP; Dorji, T; Jamtsho, S; Nirola, DK; Pema, D; Tenzin, K; Wangmo, S, 2023) |
| "Fifth, treating neonatal seizures (including electrographic-only seizures) to achieve a lower seizure burden may be associated with improved outcome (expert agreement)." | 3.01 | Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures. ( Abend, NS; Auvin, S; Boylan, G; Brigo, F; Cilio, MR; De Vries, LS; Elia, M; Espeche, A; Hahn, CD; Hartmann, H; Inder, T; Jette, N; Kakooza-Mwesige, A; Mader, S; Mizrahi, EM; Moshé, SL; Nagarajan, L; Noyman, I; Nunes, ML; Pressler, RM; Samia, P; Shany, E; Shellhaas, RA; Subota, A; Triki, CC; Tsuchida, T; Vinayan, KP; Wilmshurst, JM; Yozawitz, EG, 2023) |
| "Epilepsy is a common neurological condition with a worldwide prevalence of around 1%." | 2.82 | Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Cividini, S; Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C, 2022) |
| "Carbamazepine and phenytoin were the drugs most strongly associated with decreases in T4 and T3 levels while topiramate had the greatest elevating effect on TSH." | 2.82 | Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis. ( Cai, M; Guo, X; Han, Y; Lin, W; Yang, J; Zhong, R, 2022) |
| "The phenytoin treatment causes cerebellar defect and anemia." | 2.82 | The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches. ( Agrawal, M; Dhurandhar, Y; Panda, SP, 2022) |
| " Indeed, because of its interesting pharmacokinetic properties, it is often used outside of the labeled indications, notably in the neurocritical setting as prophylaxis of epileptic seizures." | 2.82 | Pharmacokinetic considerations surrounding the use of levetiracetam for seizure prophylaxis in neurocritical care - an overview. ( Amadori, E; D'Onofrio, G; Lattanzi, S; Riva, A; Rose, K; Striano, P; Verrotti, A, 2022) |
| "The clinical spectrum of tics induced by antiepileptic drugs (AED), a form of 'secondary Tourettism', is largely unknown." | 2.72 | Tics induced by antiepileptic drugs: a pragmatic review. ( Angus-Leppan, H; Peters, J; Vijiaratnam, N, 2021) |
| "We systematically reviewed the existing literature on the cosmetic adverse effects of antiseizure medications (ASMs) in order to depict a clear picture of these unwanted side effects of ASMs with a particular attention to hair loss, hirsutism, acne, and gingival hyperplasia." | 2.72 | Cosmetic adverse effects of antiseizure medications; A systematic review. ( Asadi-Pooya, AA; Mirzaei Damabi, N; Rostaminejad, M; Zeraatpisheh, Z, 2021) |
| "The objective of this study was to compare the efficacy and safety of a chronotherapeutic dosing schedule of phenytoin and carbamazepine versus a conventional dosing schedule for the treatment of tonic-clonic epileptic patients." | 2.72 | Chronotherapeutic dose schedule of phenytoin and carbamazepine in epileptic patients. ( Mahesh, SD; Sangle, S; Yegnanarayan, R, 2006) |
| "Seizure activity in patients with acute liver failure (ALF) may increase cerebral oxygen requirements and worsen cerebral edema." | 2.71 | Prophylactic phenytoin does not improve cerebral edema or survival in acute liver failure--a controlled clinical trial. ( Acharya, SK; Batra, Y; Bhatia, V, 2004) |
| " We measured the plasma phenytoin concentrations at steady-state in 20 routinely treated Japanese patients, and evaluated the usefulness of genotyping the CYP2C subfamily in predicting plasma concentrations and determining the dosage regimens of phenytoin." | 2.71 | Evaluation of phenytoin dosage regimens based on genotyping of CYP2C subfamily in routinely treated Japanese patients. ( Aiba, T; Hashimoto, Y; Hongou, K; Miyawaki, T; Taguchi, M; Takizawa, M; Yagi, S, 2005) |
| "All phenytoin was administered intravenously, and fosphenytoin was given intravenously or intramuscularly (physician preference)." | 2.70 | Randomized evaluation of adverse events and length-of-stay with routine emergency department use of phenytoin or fosphenytoin. ( Clements, EA; Cochran, MS; Coplin, WM; O'Neil, BJ; Rebuck, JA; Rhoney, DH, 2002) |
| " All prior pharmacokinetic studies had the first plasma sample obtained 30 min after IM administration." | 2.70 | Fosphenytoin: pharmacokinetics and tolerance of intramuscular loading doses. ( DeToledo, J; Gidal, B; Morgan, RO; Pryor, FM; Ramsay, RE, 2001) |
| "Phenytoin (PHT) has been widely used intravenously for the treatment of seizures since 1956, and for many years, it has been considered first-line therapy for status epilepticus." | 2.70 | A prospective study of the incidence of the purple glove syndrome. ( Anandan, JV; Barkley, GL; Burneo, JG, 2001) |
| "The most important factor determining seizure recurrence was continued therapy, which was the case for barbiturates, phenytoin and valproate." | 2.69 | Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study. ( Chadwick, D, 1999) |
| "Phenytoin (PHT) is a widely prescribed antiepileptic drug." | 2.69 | Genotoxicity of the anticonvulsant drug phenytoin (PHT): a follow-up study of PHT-untreated epileptic patients. I. Sister chromatid exchange (SCE) analysis. ( Goyle, S; Kaul, A, 1999) |
| "Before epilepsy was diagnosed there was no difference in overall fracture rate between patients and controls (RR = 1." | 2.69 | Fracture risk is increased in epilepsy. ( Dam, M; Mosekilde, L; Rejnmark, L; Tigaran, C; Tigaran, S; Vestergaard, P, 1999) |
| "Lamotrigine is an effective add-on therapy against a range of epileptic seizure types." | 2.69 | Lamotrigine monotherapy in newly diagnosed untreated epilepsy: a double-blind comparison with phenytoin. ( Abbott, R; Dellaportas, CI; Findley, LJ; Gibberd, FB; Gross, M; Park, DM; Perkin, GD; Steiner, TJ, 1999) |
| " Two analyses of adverse events are presented: tolerability and safety." | 2.69 | Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study. ( Bernstein, P; Faught, RE; Holmes, GL; Magnus-Miller, L; McLean, MJ; Morrell, MJ; Privitera, MD; Rose-Legatt, A; Willmore, LJ, 1999) |
| "Odds for epilepsy were higher among people who had positive family history (O." | 2.69 | A case control study and one year follow-up of registered epilepsy cases in a resettlement colony of North India, a developing tropical country. ( Chopra, JS; Kaur, P; Sawhney, IM; Singh, A; Suri, G, 1999) |
| "This open-label study investigated the pharmacokinetic interaction of phenytoin (PHT) and felbamate (FBM)." | 2.69 | Coadministration of phenytoin and felbamate: evidence of additional phenytoin dose-reduction requirements based on pharmacokinetics and tolerability with increasing doses of felbamate. ( Lyness, WH; Perhach, JL; Rosenberg, A; Sachdeo, R; Sachdeo, S; Shumaker, RC; Wagner, ML; Ward, D, 1999) |
| " No significant difference was observed in any of the pharmacokinetic parameters like Cmax, Cmin, Tmax, t1/2a, t1/2e and AUC of DPH after GFJ administration as compared to control values in healthy volunteers and epileptic patients." | 2.69 | Lack of pharmacokinetic interaction between grapefruit juice and phenytoin in healthy male volunteers and epileptic patients. ( Garg, SK; Kumar, N; Prabhakar, S, 1999) |
| "Fosphenytoin was as well tolerated as intramuscular placebo at the injection site." | 2.68 | Safety and tolerance of multiple doses of intramuscular fosphenytoin substituted for oral phenytoin in epilepsy or neurosurgery. ( Campbell, K; Garnett, WR; Henkin, SA; Kugler, AR; Pellock, JM; Ramsay, RE; Wilder, BJ, 1996) |
| " When PB in the dosage of 30-60 mg/d was used in combination with PHT the above mentioned changes were not observed." | 2.68 | Brainstem auditory evoked potentials in epileptics on different anti-epileptic drugs. ( Gupta, HL; Mukhopadhyay, S; Panjwani, U; sel Vamurthy, W; Singh, SH; Thakur, L, 1996) |
| "Lamotrigine (LTG) is a new antiepileptic drug (AED), chemically unrelated to the drugs in current use." | 2.68 | Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication. ( Jürgens, U; May, TW; Rambeck, B, 1996) |
| "The population pharmacokinetic parameters of phenytoin were estimated using routine therapeutic drug monitoring data from 116 epileptic patients." | 2.68 | Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: analysis with a dose-dependent clearance model. ( Furusho, K; Hashimoto, Y; Hattori, H; Inui, K; Koue, T; Odani, A; Otsuki, Y; Takano, M; Takayanagi, K; Yasuhara, M, 1996) |
| "To develop simple clinical rules for dosing phenytoin (PHT) using computer simulations, then to test the rules for accuracy and safety on actual patient data." | 2.67 | Clinical rules for phenytoin dosing. ( Privitera, MD, 1993) |
| "On treatment with carbamazepine (n = 27) and phenytoin (n = 8), the excretion of alpha 1-microglobulin was significantly increased, as compared with the healthy controls." | 2.67 | Renal tubular dysfunction following treatment with anti-epileptic drugs. ( Korinthenberg, R; Wehrle, L; Zimmerhackl, LB, 1994) |
| " Each patient received an individualized loading dose and maintenance dosage targeted at a 60-ng/ml plasma FNR concentration." | 2.67 | Flunarizine for treatment of partial seizures: results of a concentration-controlled trial. ( Drake, ME; Mikati, M; Olson, L; Pellock, JM; Pledger, GW; Sackellares, JC; Sahlroot, JT; Treiman, DM; Tsay, JY; Wright, FS, 1994) |
| "We estimated individual and population Michaelis-Menten pharmacokinetic parameters for phenytoin (DPH) in epileptic patients attending our neurology clinic using the computer programme." | 2.67 | Pharmacokinetics of phenytoin in routine clinic patients in Malaysia. ( Chand, P; Ismail, R; Rahman, AF, 1994) |
| " Consequently, the controlled trial was designed to account for this interaction by reducing the phenytoin dosage by approximately 20% during the felbamate treatment period and using matching placebo capsules to maintain the blind." | 2.67 | Dosage adjustments in response to monitored plasma concentrations: can unblinded staff adhere to objective criteria? ( Pledger, GW; Sahlroot, JT, 1994) |
| " Median AUCs of CBZ, VPA and PHT during a dosage interval did not differ significantly after treatment with OXC and placebo." | 2.67 | A double-blind, placebo-controlled interaction study between oxcarbazepine and carbamazepine, sodium valproate and phenytoin in epileptic patients. ( Blacklaw, J; Brodie, MJ; Connelly, D; Forrest, G; Gillham, RA; McKee, PJ; Walker, SM, 1994) |
| " The results suggest that no overall dosage adjustments are required when switching from one brand to the other." | 2.67 | Comparison of the effectiveness of two oral phenytoin products and chronopharmacokinetics of phenytoin. ( Morton, DJ; Petker, MA, 1993) |
| "Felbamate is a novel antiepileptic drug that is now available in the United States." | 2.67 | Effect of felbamate on carbamazepine and its major metabolites. ( Graves, NM; Leppik, IE; Remmel, RP; Wagner, ML, 1993) |
| "The comparative bioavailability of two phenytoin products, Phenytoin Sodium (CAPS (Pvt) Ltd) and Epanutin (Parke-Davis (Pty) Ltd) was studied." | 2.66 | A comparative bioavailability of 2 oral solid phenytoin dosage forms. ( Morton, DJ; Naik, D, 1989) |
| "1." | 2.66 | A multicentre study of vigabatrin for drug-resistant epilepsy. ( Ben-Menachem, E; Browne, TR; Mattson, RH; Miketta, RM; Penry, JK; Sherry, KM; Smith, DB; Szabo, GK; Treiman, DM; Wilder, BJ, 1989) |
| "Safety and efficacy studies of new antiepileptic drugs require strict adherence to prescribed dosage regimens." | 2.66 | Compliant populations: variability in serum concentrations. ( Graves, NM; Holmes, GB; Leppik, IE, 1988) |
| "Both carbamazepine and phenytoin were associated with significantly lower incidences of intolerable side effects than were primidone or phenobarbital." | 2.66 | Results of a nationwide Veterans Administration Cooperative Study comparing the efficacy and toxicity of carbamazepine, phenobarbital, phenytoin, and primidone. ( Collins, JF; Craft, B; Cramer, JA; Mattson, RH; Novelly, RA; Smith, DB, 1987) |
| "Decreased libido and impotence were more common in patients given primidone." | 2.66 | Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. ( Browne, TR; Collins, JF; Cramer, JA; Delgado-Escueta, AV; Mattson, RH; McCutchen, CB; McNamara, JO; Smith, DB; Treiman, DM; Williamson, PD, 1985) |
| "Phenytoin has been widely prescribed alone; our results indicate that sodium valproate may also be used as a single drug in the treatment of several types of epilepsy." | 2.65 | Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy. ( Johnson, RH; Lambie, DG; Melville, ID; Nanda, RN; Shakir, RA, 1981) |
| " Absolute bioavailability of IM PB was 101 +/- 11%." | 2.65 | Kinetics of phenobarbital in normal subjects and epileptic patients. ( Comfort, CP; Friel, PN; Kaluzny, SP; Levy, RH; Wilensky, AJ, 1982) |
| " Plasma DPH levels of more than 10 mug/ml were achieved within 16 to 38 hr in the children given loading doses and within 5 days in the conventionally dosed children." | 2.64 | Loading and conventional dose therapy with phenytoin in children: kinetic profile of parent drug and main metabolite in plasma. ( Höjer, B; Rane, A; Wilson, JT, 1976) |
| "Ambulant patients with recently diagnosed generalised or psychomotor seizure disorders or both were randomly assigned to two dosage regimens of phenytoin." | 2.64 | Phenytoin dosage in ambulant epileptic patients. ( Alberts, M; Terrence, C, 1978) |
| " The data indicate that the dosage regimen described is suitable for patients on oral phenytoin who have to be transferred to im drug for short periods." | 2.64 | Oral and intramuscular phenytoin. ( Ramsay, RE; Wilder, BJ, 1976) |
| " We aimed to clarify the effects of genetic polymorphisms in both enzymes on daily PHT maintenance dosage in Asian epileptic patients by meta-analysis." | 2.58 | The association between CYP2C9/2C19 polymorphisms and phenytoin maintenance doses in Asian epileptic patients: A systematic review and meta-analysis . ( Ai, CZ; Li, W; Liao, K; Liu, Y; Yu, X, 2018) |
| "Epilepsy is a common neurological condition with a worldwide prevalence of around 1%." | 2.55 | Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017) |
| " The impacts of CYP2C19 and multidrug resistance protein 1 C3435T variants on phenytoin pharmacokinetic and clinical outcomes are unclear and require further investigation." | 2.55 | Impact of Genetic Polymorphisms on Phenytoin Pharmacokinetics and Clinical Outcomes in the Middle East and North Africa Region. ( Dagenais, R; Elewa, H; Ensom, MHH; Wilby, KJ, 2017) |
| "Epilepsy is a common neurological condition with a worldwide prevalence of around 1%." | 2.55 | Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017) |
| "Phenytoin has been explored in over 100 different disorders; the last two promising indications tested in the clinic are breast cancer and optic neuritis." | 2.55 | Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action. ( Keppel Hesselink, JM; Kopsky, DJ, 2017) |
| "Epilepsy is one of the most important neurological disorders with high prevalence worldwide." | 2.53 | The importance of triazole scaffold in the development of anticonvulsant agents. ( Ayati, A; Emami, S; Foroumadi, A, 2016) |
| "Epilepsy affects fetal brain development during gestation in pregnant rats, therefore anti-epileptic therapy should be continued during pregnancy." | 2.53 | Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats. ( Doğan, Z; Kamışlı, Ö; Soysal, H, 2016) |
| " This article reviews the contribution of genetic polymorphisms affecting the activity of CYP2C9, the main enzyme responsible for phenytoin metabolism, to the variation in phenytoin clearance and susceptibility to adverse effects." | 2.52 | CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects. ( Franco, V; Perucca, E, 2015) |
| "Epilepsy is the commonest clinical presentation, though it may also present with headache, symptoms of raised intracranial tension, hydrocephalus and ocular symptoms depending upon the localisation of the parasitic cysts." | 2.52 | Antiepileptic drugs for seizure control in people with neurocysticercosis. ( Mathew, A; Sharma, M; Singh, T, 2015) |
| "Seizures and intracranial hemorrhage are possible medical diseases that any obstetrician may encounter." | 2.49 | Seizures and intracranial hemorrhage. ( Alexander, JM; Wilson, KL, 2013) |
| "Acute seizure and status epilepticus constitute one of the major medical emergencies in children." | 2.48 | Management of acute seizure and status epilepticus in pediatric emergency. ( Sasidaran, K; Singhi, P; Singhi, S, 2012) |
| "54; strength of evidence: low) or adverse events (RR 0." | 2.48 | Efficacy and safety of innovator versus generic drugs in patients with epilepsy: a systematic review. ( Ashaye, A; Baker, EL; Baker, WL; Coleman, CI; Kluger, J; Phung, OP; Scholle, JM; Talati, R; White, CM, 2012) |
| "Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin." | 2.47 | Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011) |
| "Studies on mechanisms of seizure generation and propagation have identified new potential targets for AEDs." | 2.45 | New antiepileptic drugs: molecular targets. ( Mula, M, 2009) |
| " Measuring antiepileptic drug levels in body fluids (therapeutic drug monitoring) is frequently used to optimise drug dosage for individual patients." | 2.44 | Therapeutic monitoring of antiepileptic drugs for epilepsy. ( Dahl, ML; Kimland, E; Tomson, T, 2007) |
| "Febrile seizures and epilepsies are common causes of CSE in infants and young children in Japan, followed by benign infantile convulsions (BIC), convulsions with gastroenteritis (CwG), and acute encephalitis with refractory CSE and intractable epilepsy (AECSEE), which are familiar disorders in Japan." | 2.44 | Treatment of convulsive status epilepticus in infants and young children in Japan. ( Sugai, K, 2007) |
| "Phenytoin has been causally implicated in three human cancers: lymphoma, myeloma and neuroblastoma, the latter specifically in the setting of foetal hydantoin syndrome." | 2.43 | Cancer risk in people with epilepsy: the role of antiepileptic drugs. ( Driever, PH; Sander, JW; Singh, G, 2005) |
| "Agents introduced for the treatment of epilepsy have also been usedsimultaneously for psychiatric indications." | 2.43 | [Anticonvulsants treatment of psychiatric disorder in elderly patients]. ( Bidzan, L, 2006) |
| " The concepts of bioavailability and bioequivalence require further consideration." | 2.41 | Is generic prescribing acceptable in epilepsy? ( Besag, FM, 2000) |
| " However, on rare occasions, they can progress to more severe cutaneous disorders, including Stevens-Johnson syndrome and toxic epidermal necrolysis." | 2.41 | Therapeutic safety monitoring: what to look for and when to look for it. ( Harden, CL, 2000) |
| "Epilepsy affects 1." | 2.41 | New antiepileptic drugs and preparations. ( Jagoda, A; Yoon, Y, 2000) |
| "Minimal requirements: seizure-prevention outcome given as fraction of cases; AED or control assigned by random or quasi-random mechanism." | 2.41 | Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. ( Temkin, NR, 2001) |
| " Rates of metabolism in children may be much faster than in nonelderly adults, requiring dosing adjustments to ensure enough medication is used to control seizures." | 2.41 | Treatment of epilepsy in 3 specialized populations. ( Leppik, IE, 2001) |
| " In this model in Wistar rats, animals which do not respond to repeated or chronic administration of anti-epileptic drugs (non-responders) can be separated from animals in whom anti-epileptics are effective (responders)." | 2.41 | Animal models of drug-resistant epilepsy. ( Löscher, W, 2002) |
| "Phenytoin has been associated predominantly with bradyarrhythmias, some of which were fatal." | 2.40 | Arrhythmia, heart rate variability, and antiepileptic drugs. ( Kennebäck, G; Tomson, T, 1997) |
| "Fosphenytoin has recently been approved as a substitute for parenteral phenytoin." | 2.40 | New drug therapy for acute seizure management. ( Morton, LD; Pellock, JM; Rizkallah, E, 1997) |
| "Felbamate, however, has been linked with substantially increased incidence of aplastic anemia, and the other new AEDs have been studied for relatively short periods of time." | 2.40 | Pharmacologic and dietary therapies in epilepsy: conventional treatments and recent advances. ( Chapman, DP; Giles, WH, 1997) |
| "Moreover, the seizure and the epilepsy type may have been incorrectly diagnosed." | 2.40 | Antiepileptic drug-induced worsening of seizures in children. ( Belmonte, A; Genton, P; Guerrini, R, 1998) |
| " When administered intramuscularly, phenytoin is poorly absorbed and can cause hemorrhagic necrosis of the soft tissues at the injection site." | 2.40 | Pediatric use of intravenous and intramuscular phenytoin: lessons learned. ( Wheless, JW, 1998) |
| " Adverse events associated with fosphenytoin generally were related to the central nervous system and were similar to those associated with phenytoin, except for a higher incidence of transient pruritus with fosphenytoin." | 2.40 | Clinical experience with fosphenytoin in adults: pharmacokinetics, safety, and efficacy. ( Knapp, LE; Kugler, AR, 1998) |
| "Enzymatic biotransformation is the principal determinant of the pharmacokinetic properties of most antiepileptic drugs (AEDs), although some agents are excreted by the kidneys predominantly as unchanged drug." | 2.40 | Pharmacokinetics of antiepileptic drugs. ( Browne, TR, 1998) |
| " The long-term use of phenytoin is not recommended for patients with loss of locomotion, marked cognitive impairment, or symptoms and signs of cerebellar disease." | 2.40 | Phenytoin: effective but insidious therapy for epilepsy in people with intellectual disability. ( Iivanainen, M, 1998) |
| "Plasma concentrations of lamotrigine, an antiepileptic drug obtained in three adult controlled clinical trials conducted in the United States were pooled and analyzed using NONMEM, a population pharmacokinetic computer program, to facilitate development of dosing guidelines." | 2.40 | Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy. ( Chen, C; Cox, E; Fiedler-Kelly, J; Grasela, TH; Risner, ME; Womble, GP, 1999) |
| " Because dosing is often modest, cost should rarely be the overriding factor in choosing a drug for a patient with newly diagnosed epilepsy in the developed world." | 2.40 | Monostars: an aid to choosing an antiepileptic drug as monotherapy. ( Brodie, MJ, 1999) |
| "Oxcarbazepine (OXC) was developed to provide a compound chemically similar enough to CBZ to mimic its efficacy and overall safety while improving its side-effect profile." | 2.40 | Oxcarbazepine. ( Tecoma, ES, 1999) |
| " TPM was added to the baseline antiepileptic drug (AED) at a dosage of up to 800 mg/day, after which the baseline drug was discontinued, when possible." | 2.39 | Drug interaction profile of topiramate. ( Bourgeois, BF, 1996) |
| "Sequelae and risk for recurrence of SE are primarily related to the underlying cause." | 2.39 | Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. ( Mitchell, WG, 1996) |
| "Fosphenytoin is a water-soluble disodium phosphate ester of phenytoin that is converted in plasma to phenytoin." | 2.39 | Intravenous administration of fosphenytoin: options for the management of seizures. ( DeToledo, J; Ramsay, RE, 1996) |
| "Fosphenytoin is a new phenytoin prodrug that fulfills many of the properties of an ideal anticonvulsant drug." | 2.39 | Intramuscular use of fosphenytoin: an overview. ( Ramsay, RE; Uthman, BM; Wilder, BJ, 1996) |
| "Fosphenytoin has fewer local adverse effects (e." | 2.39 | Pharmacology and pharmacokinetics of fosphenytoin. ( Browne, TR; Eldon, MA; Kugler, AR, 1996) |
| " Adverse effects of antiepileptic treatment may affect the patient's quality of life to an even greater extent than the occurrence of seizures." | 2.39 | Adverse effects of established and new antiepileptic drugs: an attempted comparison. ( Gram, L; Rogvi-Hansen, B, 1995) |
| " A drug concentration, however, can only be regarded as a guide around which to alter the dosage according to the patient's clinical condition." | 2.39 | Optimisation of antiepileptic drug therapy. The importance of serum drug concentration monitoring. ( Yukawa, E, 1996) |
| "Fosphenytoin has advantages over phenytoin injection that are related to its greater aqueous solubility, which obviates the extreme alkalinity, propylene glycol, and ethanol needed in the injectable phenytoin formulation." | 2.39 | Safety of fosphenytoin sodium. ( Benezra, DA; Fierro, LS; Savulich, DH, 1996) |
| "Vigabatrin is an irreversible inhibitor of GABA transaminase." | 2.39 | [Antiepileptic drugs: mechanism of action]. ( Mercadé Cerdá, JM, 1996) |
| "The diagnosis of myoclonus was more difficult than those of epilepsy, because the clarification of pathogenesis and definition of diagnosis was lacked." | 2.38 | [Diagnosis and therapy of epilepsy and myoclonus]. ( Okamoto, Y; Ota, K, 1993) |
| " The usual phenytoin (PHT) dosage in adults is 4-6 mg/kg per day, but children may need a dosage three to five times higher." | 2.38 | Metabolism of antiepileptic medication: newborn to elderly. ( Leppik, IE, 1992) |
| "Rare, serious adverse effects of antiepileptic drugs (AEDs) include hepatotoxicity and bone marrow suppression." | 2.38 | Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy. ( Wyllie, E; Wyllie, R, 1991) |
| " In order to use these effectively, the critical care nurse must be aware of the indications and controversies surrounding their use, the patho-physiologic conditions that impact on the disposition, and appropriate dosing and monitoring of these agents in the critical care setting." | 2.38 | Anticonvulsants: pharmacotherapeutic issues in the critically ill patient. ( Dupuis, RE; Miranda-Massari, J, 1991) |
| "Valproic acid is a new antiepileptic drug." | 2.36 | Valproic acid. Review of a new antiepileptic drug. ( Bruni, J; Wilder, BJ, 1979) |
| "Valproic acid has become a regular component of antiepileptic therapy." | 2.36 | [Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)]. ( Fröscher, W; Gugler, R; Schulz, HU, 1978) |
| "Phenytoin (PHT) is a first-line antiepileptic drug in clinics, which could decrease neuronal bioelectric activity by blocking the voltage-operated sodium channels." | 1.91 | Calcium Phosphate-Based Nanoformulation Selectively Abolishes Phenytoin Resistance in Epileptic Neurons for Ceasing Seizures. ( Cao, D; Guan, Q; Li, M; Luo, Z; Mao, X; Wang, X, 2023) |
| "Medicinal treatment against epilepsy is faced with intractable problems, especially epileptogenesis that cannot be blocked by clinical antiepileptic drugs (AEDs) during the latency of epilepsy." | 1.91 | ROS/Electro Dual-Reactive Nanogel for Targeting Epileptic Foci to Remodel Aberrant Circuits and Inflammatory Microenvironment. ( Chen, Q; Fan, H; Guo, Y; Jiang, C; Li, K; Liu, P; Sun, T; Zhou, Z, 2023) |
| "Epilepsy is a chronic neurological disorder that is characterized by episodes of seizure." | 1.72 | Clinical Evaluation of Levetiracetam in the Treatment of Epilepsy. ( Guan, S; Liu, J; Qian, F; Wang, Y; Wu, H; Yang, J, 2022) |
| "When selecting an antiseizure medication, consideration should be given to the individual patient's risks of adverse consequences on other organ systems." | 1.72 | Long-Term Effects of Antiseizure Medications. ( LoPinto-Khoury, C, 2022) |
| "Since arrhythmia often accompanies seizures, patients suffering from epilepsy are frequently co-treated with antiepileptic and antiarrhythmic drugs." | 1.72 | Ranolazine Interacts Antagonistically with Some Classical Antiepileptic Drugs-An Isobolographic Analysis. ( Banach, M; Borowicz-Reutt, K, 2022) |
| "Carbamazepine can cause hypersensitivity reactions in ~10% of patients." | 1.62 | Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine. ( Carr, DF; Maggs, JL; Marson, AG; Meng, X; Park, BK; Pertinez, H; Pirmohamed, M; Yip, VLM, 2021) |
| "Epileptic spasms are often preceded by focal (or multifocal) seizures." | 1.62 | Potential induction of epileptic spasms by nonselective voltage-gated sodium channel blockade: Interaction with etiology. ( Heesch, J; Hussain, SA; Numis, AL; Rajaraman, RR; Sankar, R; Weng, J, 2021) |
| "Pharmaco-resistant Epilepsy has been a major challenge for medical interventions in controlling seizures." | 1.62 | Gene Expression Analysis Identifies Cholesterol Metabolism Dysregulation in Hippocampus of Phenytoin-Resistant Pentylenetetrazol-Kindled Epileptic Mice. ( Amalakanti, S; Bhat, UA; Chakravarty, S; Khandelwal, N; Kumar, A; Mylavarapu, MB; Sundarachary, NV, 2021) |
| "Carbamazepine was the second most common drug followed by lamotrigine and valproic acid." | 1.62 | Post-stroke epilepsy and antiepileptic drug use in men and women. ( Linnér, L; Loikas, D; Sundström, A; von Euler, M; Wettermark, B, 2021) |
| " Similar dose-related responses were seen following the week-long dosing protocol for carbamazepine, phenobarbital, and phenytoin, and these responses were associated with drug levels that were in the human therapeutic range." | 1.62 | Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency. ( Bertram, EH; Edelbroek, P, 2021) |
| "Epilepsy is very difficult to treat and often involves the combination of two or more AEDs." | 1.56 | Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database. ( Hayashi, T; Noguchi, Y; Tachi, T; Takaoka, M; Teramachi, H, 2020) |
| "Lacosamide is a novel anticonvulsant that acts by enhancing sodium channel slow inactivation." | 1.56 | Therapeutic Monitoring of Lacosamide in Japanese Patients With Epilepsy: Clinical Response, Tolerability, and Optimal Therapeutic Range. ( Araki, Y; Fukushima, Y; Imai, K; Kagawa, Y; Takahashi, Y; Terada, K; Yamamoto, Y, 2020) |
| "The study aims to test the effect of influenza vaccination on phenytoin, CYP2C9, and IFNγ levels in epileptic patients receiving phenytoin monotherapy METHODS: Thirty-one epileptic patients receiving stable-dose phenytoin monotherapy were enrolled onto the study." | 1.56 | Influenza immunization does not predominantly alter levels of phenytoin, and cytochrome P-450 enzymes in epileptic patients receiving phenytoin monotherapy. ( Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Manoyana, N; Nadsasarn, A; Pinyopornpanish, K; Soontornpun, A; Tanprawate, S, 2020) |
| "His phenytoin dose was increased, and he was started on calcium supplementation." | 1.51 | Paradoxical deterioration in seizure control due to anticonvulsant-induced hypocalcaemia. ( Cachia, MJ; Gauci, Z; Mifsud, S; Rizzo, C, 2019) |
| "Phenytoin has been decreasingly used because of the high interindividual variability in drug concentration and the narrow therapeutic window." | 1.51 | Optimal Dosing Regimen of Phenytoin for Korean Epilepsy Patients: From Premature Babies to the Elderly. ( Chae, D; Guk, J; Kim, JH; Lee, SG; Park, K, 2019) |
| " for population pharmacokinetic modeling." | 1.51 | Estimation of Phenytoin Pharmacokinetic Parameters in Saudi Epileptic Patients. ( Alotaibi, M; Alqahtani, S; Alsultan, A; Alzaidi, T, 2019) |
| " The aim of this study was to develop a population pharmacokinetic (PPK) model to describe serum phenytoin concentrations after the intravenous administration of fosphenytoin in adult and elderly epileptic patients." | 1.51 | Population Pharmacokinetic Analysis of Phenytoin After Intravenous Administration of Fosphenytoin in Adult and Elderly Epileptic Patients. ( Higuchi, K; Hirakawa, M; Hirota, T; Ieiri, I; Kakara, M; Kashihara, Y; Yamashita, D, 2019) |
| " Our aim was to translate a recently published comprehensive CNS physiologically-based pharmacokinetic (PBPK) model from rat to human, and to predict drug concentration-time profiles in multiple CNS compartments on available human data of four drugs (acetaminophen, oxycodone, morphine and phenytoin)." | 1.48 | Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach. ( Beukers, MW; Danhof, M; de Lange, ECM; Huntjens, DR; Kokki, H; Kokki, M; Krauwinkel, W; Proost, JH; Välitalo, PA; van Hasselt, JGC; Vermeulen, A; Wong, YC; Yamamoto, Y, 2018) |
| "Evidence for the comparative teratogenic risk of antiepileptic drugs is insufficient, particularly in relation to the dosage used." | 1.48 | Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F, 2018) |
| " We studied whether glucocorticoid receptor (GR) silencing or inhibition in human epileptic brain endothelial cells (EPI-ECs) functionally impacts drug bioavailability across an in vitro model of the blood-brain barrier (BBB) by CYP-multidrug transporter (multidrug resistance protein 1, MDR1) mechanisms." | 1.48 | Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood-brain barrier model. ( Bingaman, W; Ghosh, C; Gonzalez-Martinez, J; Hossain, M; Janigro, D; Khan, S; Marchi, N; Mishra, S; Najm, I, 2018) |
| "Levetiracetam treatment did not affect bone strength, bone mass, and bone turnover." | 1.46 | Effects of the Antiepileptic Drugs Phenytoin, Gabapentin, and Levetiracetam on Bone Strength, Bone Mass, and Bone Turnover in Rats. ( Izumo, N; Kanda, J; Kobayashi, Y; Onodera, K; Shimakura, T; Takahashi, HE; Wakabayashi, H; Yamamoto, N, 2017) |
| " Therefore, H3Rs may have implications for the treatment of degenerative disorders associated with impaired memory function and may represent a novel therapeutic pharmacological target to tackle cognitive problems associated with the chronic use of antiepileptic drugs." | 1.43 | Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats. ( Kieć-Kononowiczc, K; Saad, A; Sadek, B; Shafiullah, M; Subramanian, D; Łażewska, D, 2016) |
| " Long-term use of phenytoin can lead to axonal shrinkage and random clusters of nerve demyelination [1]." | 1.43 | Lacking the 'protective label' of diabetes: Phenytoin-induced distal symmetrical peripheral neuropathy. A clinical case report. ( Mahon, AM, 2016) |
| "Weight gain and alopecia were the most common patient-reported CSEs in this study, and weight gain was the most likely cosmetic side effect to result in dosage adjustment or medication discontinuation." | 1.42 | Cosmetic side effects of antiepileptic drugs in adults with epilepsy. ( Buchsbaum, R; Chen, B; Choi, H; Detyniecki, K; Hirsch, LJ; Javed, A; Kato, K; Legge, A; Moeller, J, 2015) |
| "To use a physiologically based pharmacokinetic (PBPK) modelling system to predict the serum levels achieved by two different intravenous loading doses of phenytoin." | 1.42 | Comparing paediatric intravenous phenytoin doses using physiologically based pharmacokinetic (PBPK) modelling software. ( Appleton, R; Batchelor, H; Hawcutt, DB, 2015) |
| "CNS inflammation is characterized by a disturbance of glial cell functions." | 1.40 | Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation. ( Dambach, H; Faustmann, PM; Haase, CG; Hinkerohe, D; Hufnagel, A; Moinfar, Z; Prochnow, N; Stienen, MN, 2014) |
| "Phenytoin was most commonly implicated (93 %) in rash formation compared with other AEDs (P < 0." | 1.40 | EMPACT syndrome: limited evidence despite a high-risk cohort. ( Barker, CA; Bishop, AJ; Chang, M; Lacouture, ME, 2014) |
| "Phenytoin-treated kindled animals were associated with learning and memory deficit, while tacrine supplementation improved memory deficit with increased seizure severity score." | 1.40 | Adjuvant anticholinesterase therapy for the management of epilepsy-induced memory deficit: a critical pre-clinical study. ( Goel, RK; Mishra, A, 2014) |
| "Tamoxifen is a prodrug, requiring cytochrome P450 enzyme-mediated metabolism to form the active metabolite endoxifen." | 1.40 | Profound reduction in the tamoxifen active metabolite endoxifen in a patient on phenytoin for epilepsy compared with a CYP2D6 genotype matched cohort. ( Gryn, SE; Kim, RB; Teft, WA, 2014) |
| " In order to evaluate the oral bioavailability of PHT, two groups were administered with oral or intraperitoneal doses of 100mg/kg and plasma level were measured." | 1.40 | Chronic administration of phenytoin induces efflux transporter overexpression in rats. ( Alvariza, S; Fagiolino, P; Feria-Romero, I; Orozco-Suárez, S; Vázquez, M, 2014) |
| "Myotonic dystrophy is a clinically and genetically heterogeneous multisystem disorder with a prevalence of 1 in 8000 in the general population." | 1.40 | Concurrence of myotonic dystrophy and epilepsy: a case report. ( Worku, DK, 2014) |
| " In phase IV screening, the bioavailability of active compounds was assessed on oral administration." | 1.40 | Preliminary anticonvulsant and toxicity screening of substituted benzylidenehydrazinyl-N-(6-substituted benzo[d]thiazol-2-yl)propanamides. ( Ali, R; Siddiqui, N, 2014) |
| "Hyperammonemia was defined as a plasma ammonia level exceeding 100 μg/dl with reference to the standard range and previous reports." | 1.39 | Risk factors for hyperammonemia in pediatric patients with epilepsy. ( Imai, K; Inoue, K; Inoue, Y; Itoh, K; Kagawa, Y; Mishima, N; Takahashi, Y; Yamamoto, Y; Yazawa, R, 2013) |
| "Phenytoin is known to cause conduction slowing." | 1.39 | Fosphenytoin induced transient pendular nystagmus. ( Shaikh, AG, 2013) |
| " P-gp polymorphisms may also affect phenytoin efficacy by altering its bioavailability (F)." | 1.39 | Studies on pharmacokinetic mechanism of phenytoin resistance in refractory epilepsy. ( Huang, JD; Huang, YS; Lai, ML; Tien, YE, 2013) |
| "To investigate PHT performance in reaching therapeutic target serum concentration rapidly and sustainably, a Bayesian forecasting (BF) regimen was compared to conventional dosing (CD), according to the official summary of product characteristics." | 1.39 | Intravenous phenytoin: a retrospective analysis of Bayesian forecasting versus conventional dosing in patients. ( Mühlebach, S; Tobler, A, 2013) |
| " Nevertheless, although the association of these genes with PTH-induced adverse effects has been well-documented in adult populations, this is the first report examining the influence of these genetic polymorphisms on PTH plasma levels and toxicity in a pediatric patient." | 1.39 | Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms. ( Dorado, P; Llerena, A; López-Torres, E; Martínez-Antón, J; Peñas-Lledó, EM, 2013) |
| " In addition, there appeared to be a dose-response relationship between stroke risk and PHT prescriptions." | 1.39 | Comparative stroke risk of antiepileptic drugs in patients with epilepsy. ( Hsieh, CY; Lai, EC; Lin, SJ; Yang, YH, 2013) |
| "Phenytoin plasma levels were analyzed by reversed phase HPLC method and pharmacokinetic parameters such as area under the concentration curve (AUC), maximum concentration (C(max)), time to C(max) (t(max)) and half-life (t(1/2)) were estimated by noncompartmental analysis using PK Solutions® software." | 1.38 | Genetic polymorphism of NAT2 metabolizing enzymes on phenytoin pharmacokinetics in Indian epileptic patients developing toxicity. ( Jain, DC; Madhuri, B; Manjari, T; Murali, M; Raghavan, S; Vivekanandhan, S, 2012) |
| "Phenytoin was used in 56 patients (22%) with the majority (n= 43) receiving intravenous phenytoin." | 1.38 | Seizure management at Auckland City Hospital Emergency Department between July and December 2009: time for a change? ( Bergin, P; Jones, P; Rosemergy, I; Walker, E, 2012) |
| "Phenobarbital has been in clinical use as an antiepileptic drug (AED) since 1912." | 1.38 | How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)? ( Bialer, M, 2012) |
| "Phenytoin levels were undetectable despite a high dose." | 1.37 | Reduced phenytoin levels in an epileptic patient following Roux-En-Y gastric bypass for obesity. ( Footitt, D; Mahon, D; Pournaras, DJ; Welbourn, R, 2011) |
| "Stroke is the major cause of acquired epilepsy in the adult population." | 1.37 | An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges. ( Delorenzo, RJ; Deshpande, LS; Ziobro, JM, 2011) |
| "We determined PHT bioavailability during steady-state therapy by 1) measurement of the two principal deconjugated PHT urinary metabolites, 5-(4-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) and 5-(3,4-dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin (DHD); and 2) direct determination of absolute bioavailability after simultaneous administration of an oral formulation and parenteral stable-labeled PHT (SL-PHT)." | 1.37 | Excretion of the principal urinary metabolites of phenytoin and absolute oral bioavailability determined by use of a stable isotope in patients with epilepsy. ( Aliwarga, T; Brundage, RC; Cloyd, JC; Goel, V; Leppik, IE; Marino, SE; Remmel, RP, 2011) |
| " We identified significant associations of CYP2C9 variant alleles with presence of phenytoin (PHT) adverse drug reactions (ADRs) and of GSTM1 copy number variation with the presence of carbamazepine ADRs." | 1.37 | A candidate gene study of antiepileptic drug tolerability and efficacy identifies an association of CYP2C9 variants with phenytoin toxicity. ( Da Cruz, AL; Depondt, C; Espel, RS; Godard, P; Lienard, P; Pandolfo, M, 2011) |
| "Phenytoin use was associated with a statistically significant increased risk of fractures OR=1." | 1.37 | Association of antiepileptic drugs, vitamin D, and calcium supplementation with bone fracture occurrence in epilepsy patients. ( Abner, E; Espinosa, PS; Perez, DL; Ryan, M, 2011) |
| " The drug combination elevated the plasma level of PHT in a patient on chemotherapy with capecitabine for colorectal cancer." | 1.37 | [A case of toxicity caused by drug interaction between capecitabine and phenytoin in patient with colorectal cancer]. ( Fukui, E; Kawahara, K; Sakurai, M; Ueda, R; Yamada, R, 2011) |
| "Curcumin was co-administered with sub-therapeutic dose of valproate 60min before PTZ injection." | 1.37 | Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. ( Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH, 2011) |
| "Phenytoin levels were subjected to analysis of variance and the dose effect was approached using a multiple comparison test." | 1.37 | Capecitabine-phenytoin interaction is dose dependent with an unexpected time course. ( de Los Ríos la Rosa, F; Privitera, M, 2011) |
| "Epilepsy was confirmed in 58 cases." | 1.37 | [Epilepsy in elderly]. ( Kotov, AS; Rudakova, IG, 2011) |
| "Epileptic seizures drive expression of the blood-brain barrier efflux transporter P-glycoprotein via a glutamate/cyclooxygenase-2 mediated signalling pathway." | 1.36 | COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats. ( Aronica, E; Edelbroek, PM; Gorter, JA; Holtman, L; Pekcec, A; Potschka, H; Schlichtiger, J; van Vliet, EA; Zibell, G, 2010) |
| "Antiepileptic drugs (AEDs) have been widely used in patients with epilepsy but the adverse effects in adult Chinese patients have not been investigated." | 1.36 | Adverse effects of carbamazepine, phenytoin, valproate and lamotrigine monotherapy in epileptic adult Chinese patients. ( Wang, X; Xi, Z; Yan, Y; Zeng, K, 2010) |
| "Phenytoin is a widely used anti-seizure agent, and a good correlation is observed between its concentration in plasma and the clinical effect." | 1.36 | Determination of free and total levels of phenytoin in human plasma from patients with epilepsy by MEKC: an adequate alternative to HPLC. ( Chen, SH; Hsieh, YH; Liao, FF; Lin, PC, 2010) |
| "Phenytoin was subsequently administered for seizure prophylaxis." | 1.35 | Phenytoin toxicity due to genetic polymorphism. ( Bullock, MR; McCluggage, LK; Voils, SA, 2009) |
| "Phenytoin levels were measured and found to be grossly elevated at 170 mmol/L." | 1.35 | Phenytoin toxicity and thyroid dysfunction. ( Betteridge, T; Fink, J, 2009) |
| " TDM requests, interpretation and dosage adjustment recommendations were mainly responsible by residents." | 1.35 | Effect of pharmacist participation in the health care team on therapeutic drug monitoring utilization for antiepileptic drugs. ( Faroongsarng, D; Kaewpibal, P; Ratanajamit, C; Setthawacharavanich, S, 2009) |
| "Epilepsy has been associated with poor obstetric outcomes that could be the result of the epilepsy itself or a direct effect of anti-epileptic medication on placentation." | 1.35 | Phenytoin but not valproate directly affected in vitro trophoblast differentiation. ( Anin, S; Bates, MD; Chadwick, D; Neilson, JP; Quenby, SM; Vince, GS, 2008) |
| "Phenytoin is a drug used for the treatment of different types of seizures." | 1.35 | Undetectable phenytoin serum levels by an automated particle-enhanced turbidimetric inhibition immunoassay in a patient with monoclonal IgM lambda. ( Brauchli, YB; Krähenbühl, S; Scholer, A; Schwietert, M, 2008) |
| " The pharmacokinetics of the 260 PB concentrations at a steady-state obtained from 79 patients was described with a one-compartment open pharmacokinetic model with first-order elimination." | 1.34 | Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese. ( Goto, S; Ishitsu, T; Murata, T; Nakada, N; Nakagawa, K; Seo, T; Ueda, N, 2007) |
| "In phenobarbital-treated patients, serum levels in 73% of the patients were in therapeutic range of 10-40 microg/ml, and about 44% of phenytoin-treated patients had serum levels in therapeutic range of 10-20 microg/ml." | 1.34 | Evaluation of therapeutic drug level monitoring of phenobarbital, phenytoin and carbamazepine in Iranian epileptic patients. ( Babaei, A; Eslamai, MH, 2007) |
| "PPhenytoin was 10-fold less (1." | 1.34 | Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs. ( Cucullo, L; Hossain, M; Janigro, D; Manders, T; Marchi, N; Rapp, E, 2007) |
| "Those with epilepsy at diagnosis of macroprolactinoma were examined in detail." | 1.34 | Macroprolactinomas and epilepsy. ( Daousi, C; Deepak, D; Javadpour, M; MacFarlane, IA, 2007) |
| "Interindividual variability in intestinal absorption and bioavailability might contribute to inadequate control of seizures under treatment with carbamazepine and phenytoin." | 1.34 | Intestinal expression of cytochrome P450 enzymes and ABC transporters and carbamazepine and phenytoin disposition. ( Fried, M; Fritschy, JM; Kullak-Ublick, GA; Mueller, S; Pauli-Magnus, C; Simon, C; Stieger, B; Wieser, HG, 2007) |
| "Treatment with phenobarbital or phenytoin caused a reduction in seizure frequency, but did not improve EEG background or prevent death." | 1.34 | The natural history and treatment of epilepsy in a murine model of tuberous sclerosis. ( Erbayat-Altay, E; Gutmann, DH; Wong, M; Xu, L; Zeng, LH, 2007) |
| " Further investigations with an approach to dose assessment that includes comprehensive interpretation of both pharmacogenetic and pharmacokinetic data along with understanding of the mechanism of drug interactions in dosage adjustment is warranted." | 1.34 | Contributions of CYP2C9/CYP2C19 genotypes and drug interaction to the phenytoin treatment in the Korean epileptic patients in the clinical setting. ( Kim, JW; Lee, ST; Lee, SY, 2007) |
| " These results provide evidence of a drug target polymorphism associated with the clinical use of AEDs and set the stage for a prospective evaluation of how pharmacogenetic diagnostics can be used to improve dosing decisions in the use of phenytoin and carbamazepine." | 1.33 | Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin. ( Cavalleri, GL; Depondt, C; Goldstein, DB; Sander, JW; Schorge, S; Sen, A; Shorvon, SD; Sisodiya, SM; Soranzo, N; Tate, SK; Thom, M; Wood, NW, 2005) |
| "Permeability of the blood-brain barrier is one of the factors determining the bioavailability of therapeutic drugs and resistance to chemically different antiepileptic drugs is a consequence of decreased intracerebral accumulation." | 1.33 | RLIP76, a non-ABC transporter, and drug resistance in epilepsy. ( Awasthi, S; Awasthi, YC; Cucullo, L; Dini, G; Fazio, V; Hallene, KL; Janigro, D; Singhal, SS, 2005) |
| "Thus it is necessary to rule out ictal catatonia by electroencephalography in patients with catatonic stupor." | 1.33 | Epileptic seizures superimposed on catatonic stupor. ( Awata, S; Ebina, Y; Honda, T; Matsuoka, H; Miura, N; Shindo, T; Suzuki, K; Takano, T, 2006) |
| " The mean plasma drug concentrations at different time points and the pharmacokinetic parameters before and after piperine administration were compared by Student's t-test." | 1.33 | Effect of piperine on the steady-state pharmacokinetics of phenytoin in patients with epilepsy. ( Hota, D; Kharbanda, P; Pandhi, P; Pattanaik, S; Prabhakar, S, 2006) |
| " This has implications for dosing regimens relying on plasma phenytoin levels." | 1.33 | Free phenytoin concentration measurement in brain extracellular fluid: a pilot study. ( Belli, A; Kitchen, N; Patsalos, P; Petzold, A; Ratnaraj, N; Russo, S; Sen, J; Smith, M; Tisdall, M, 2006) |
| "A 9-year-old girl with akinetic-rigid parkinsonism with tremor is described." | 1.33 | Epilepsy, parkinsonism, and neuroleptic malignant syndrome in a child. ( Cantú-Martínez, L; Flores, Lde L; González, HC; Martínez, HR; Onofre-Castillo, J; Villarreal, HJ, 2006) |
| "Phenytoin is a known inducer of drugs metabolized by CYP2C, CYP2D, and CYP3A, but its own metabolism may be altered by drugs influencing CYP2C9 or CYP2C19, such as diazepam." | 1.32 | Phenytoin-diazepam interaction. ( Murphy, A; Wilbur, K, 2003) |
| "Oxcarbazepine was generally well tolerated during monotherapy and adjunctive therapy; 2." | 1.32 | Spotlight on oxcarbazepine in epilepsy. ( Bang, LM; Goa, KL, 2004) |
| "The average annual cost of outpatient treatment of epilepsy was found to be 47 US dollars per patient." | 1.32 | Cost of epilepsy in patients attending a secondary-level hospital in India. ( Kapoor, SK; Krishnan, A; Sahariah, SU, 2004) |
| "We describe the incidence of newly treated epilepsy in primary care and patterns of antiepileptic drug prescription, numbers of patients who remain on initial therapy and health service utilisation." | 1.32 | The outcome of initiation of antiepileptic drug monotherapy in primary care: a UK database survey. ( Buchan, S; Kerr, MP; Morgan, CL, 2004) |
| "Phenytoin (PHT) dosing regimens are often determined based on experience in those aged <65 years rather than in those aged >or=65 years." | 1.32 | Phenytoin use in elderly nursing home residents. ( Birnbaum, AK; Bowers, SE; Conway, JM; Graves, NM; Hardie, NA; Lackner, TE; Leppik, IE, 2003) |
| "The purpose of this study was to investigate the relationship of changes in the enzyme-inducing anticonvulsant daily dosage (drug score) to variations in urinary D-glucaric acid excretion and gamma-glutamyltransferase and beta-glucuronidase serum activities." | 1.31 | Relationship between changes in drug score, D-glucaric acid excretion, and gamma-glutamyltransferase and beta-glucuronidase serum activities during anticonvulsant treatment. ( Fernández, MP; Hermida, J; Tutor, JC, 2002) |
| "A 21-year-old female with West syndrome was scheduled for resection of hordeolum." | 1.31 | [Anesthetic management of a patient with West syndrome]. ( Kitajima, T; Mishio, M; Okuda, Y; Yamaguchi, S, 2000) |
| "Phenytoin toxicity was defined by clinical features and correlated with drug levels." | 1.31 | Elimination of phenytoin in toxic overdose. ( Chan, SP; Chua, HC; Tjia, H; Venketasubramanian, N, 2000) |
| "Topiramate also may inhibit synaptic conductances responsible for transmission of epileptiform discharges." | 1.31 | Effects of topiramate on sustained repetitive firing and spontaneous recurrent seizure discharges in cultured hippocampal neurons. ( Coulter, DA; DeLorenzo, RJ; Sombati, S, 2000) |
| "Phenytoin nonresponders were proposed as a model for pharmaco-resistant temporal lobe epilepsy." | 1.31 | Kindling alters the anticonvulsant efficacy of phenytoin in Wistar rats. ( Ebert, U; Löscher, W; Reissmüller, E, 2000) |
| " The validity of the pharmacokinetic models and the estimated population parameter values was tested using the naive prediction method." | 1.31 | Validation of population pharmacokinetic parameters of phenytoin using the parallel Michaelis-Menten and first-order elimination model. ( Folb, PI; McFadyen, ML; Miller, R; Seymour, MA; Valodia, PN, 2000) |
| "Levetiracetam has recently been approved as an adjunctive medication for partial seizures and frequently will be added to phenytoin." | 1.31 | Absence of pharmacokinetic drug interaction of levetiracetam with phenytoin in patients with epilepsy determined by new technique. ( Baltes, E; Browne, TR; Jensen, CM; Josephs, E; Leppik, IE; Paz, J; Szabo, GK, 2000) |
| " Since phenytoin has a narrow therapeutic index and genotyping may be carried out rapidly and at low cost, dosage adjustment based on CYP2C9 genotype, especially at the induction of therapy, would be of value in order to lower the risk of concentration dependent drug intoxications in carriers." | 1.31 | The effect of genetic polymorphism of cytochrome P450 CYP2C9 on phenytoin dose requirement. ( de Haan, K; Steijns, LS; van der Weide, J; van Weelden, MJ, 2001) |
| "Chorea is a rare side effect of anticonvulsants." | 1.31 | Anticonvulsants-induced chorea: a role for pharmacodynamic drug interaction? ( Beach, RL; D'Cruz, O; Tennison, M; Zaatreh, M, 2001) |
| "Phenytoin is an effective anticonvulsant, but high serum phenytoin concentrations may be associated with serious toxicity." | 1.31 | How high can we go with phenytoin? ( Kobayashi, J; Koren, G; Kozer, E; Minassian, BA; Parvez, S; Verjee, Z, 2002) |
| " For males, the peak concentration at 9." | 1.30 | Single oral loading dose of phenytoin: a pharmacokinetics study. ( Kaojarern, S; Mokkhavesa, C; Phuapradit, P; Ratanakorn, D, 1997) |
| " The purpose of our study was to evaluate the effects of chronic administration of valproate (VPA), phenytoin (PHT), and MK-801 on the change in seizure phenotype observed in our model system." | 1.30 | Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis. ( Applegate, CD; Ozduman, K; Samoriski, GM, 1997) |
| " AWD 140-190 thus presents an orally active and safe anticonvulsant agent, which is structurally unrelated to anticonvulsants currently used." | 1.30 | AWD 140-190: a new anticonvulsant with a very good margin of safety. ( Bartsch, R; Engel, J; Rostock, A; Rundfeldt, C; Tober, C; Unverferth, K; White, HS; Wolf, HH, 1997) |
| "Phenytoin dosing is often difficult in a clinical situation because of the non-linear nature of phenytoin metabolism at therapeutic plasma concentrations." | 1.30 | Single-point phenytoin dosage predictions in Singapore Chinese. ( Chan, E, 1997) |
| "Phenytoin is a major antiepileptic drug for treatment of limbic seizures." | 1.30 | Phenytoin's effect on the spread of seizure activity in the amygdala kindling model. ( Cramer, S; Ebert, U; Löscher, W, 1997) |
| "Invasive or complex treatments for epilepsy with partial and generalized tonic-clonic seizures should not be used until at least two AEDs have failed to control seizures." | 1.30 | If a first antiepileptic drug fails to control a child's epilepsy, what are the chances of success with the next drug? ( Camfield, CS; Camfield, PR; Dooley, JM; Gordon, K, 1997) |
| "Epilepsy is a relatively common problem in children, adults and the elderly." | 1.30 | Treatment of the epileptic patient in the dental office. ( Haller, JS; Kennedy, BT, 1998) |
| "When phenytoin, 50 mg/kg, was administered i." | 1.30 | Limbic epileptogenesis alters the anticonvulsant efficacy of phenytoin in Sprague-Dawley rats. ( Cramer, S; Ebert, U; Löscher, W, 1998) |
| "Two pharmacoeconomic studies on the treatment of acute seizures have been conducted." | 1.30 | Pharmacoeconomic considerations in treatment options for acute seizures. ( Graves, N, 1998) |
| " A further difference to the Wistar strain is the truncated dose-response with loss of anticonvulsant efficacy at 75 mg/kg in kindled Sprague-Dawley rats, which may, at least in part, explain the inconsistent results reported on the anticonvulsant efficacy of PHT in this strain in the literature." | 1.30 | Selection of phenytoin responders and nonresponders in male and female amygdala-kindled Sprague-Dawley rats. ( Cramer, S; Ebert, U; Löscher, W, 1998) |
| " In addition, a population pharmacokinetic analysis was performed." | 1.30 | The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics. ( Higuchi, S; Ieiri, I; Imai, J; Mamiya, K; Ninomiya, H; Otsubo, K; Shimamoto, J; Tashiro, N; Yamada, H; Yukawa, E, 1998) |
| "The influence of various covariates (including weight, race, smoking, gender, age, mild-to-moderate alcohol intake, and body surface area) on the population pharmacokinetic parameters of phenytoin in adult epileptic patients in South Africa was investigated." | 1.30 | Factors influencing the population pharmacokinetic parameters of phenytoin in adult epileptic patients in South Africa. ( Folb, PI; McFadyen, ML; Miller, R; Seymour, MA; Valodia, P, 1999) |
| "Phenytoin (PH) levels were determined in the head hair of twenty five patients (fourteen males and eleven females, aged from five to seventy seven years old) who were receiving this drug chronically." | 1.30 | Determination of phenytoin in sections of head hair: a preliminary study to evaluate the history of drug use. ( Assithianakis, P; Helidonis, E; Michalodimitrakis, MN; Psillakis, T; Stefis, A; Tsatsakis, AM; Vlahonikolis, IG, 1998) |
| " PB was also the most toxic drug, followed by CBZ and by PHT." | 1.30 | Anticonvulsant and neurotoxic effects of intracerebroventricular injection of phenytoin, phenobarbital and carbamazepine in an amygdala-kindling model of epilepsy in the rat. ( Alós, M; Barcia, JA; Belda, V; Rubio, P; Serralta, A, 1999) |
| "Phenytoin toxicity is an uncommon problem seen in clinical practice." | 1.30 | Paradoxical seizures in phenytoin toxicity. ( Chua, HC; Tan, CB; Tjia, H; Venketasubramanian, N, 1999) |
| " Valproate, when the proper therapeutic dosage was belatedly realized, was seen as a superior treatment for generalized and partial epilepsies." | 1.30 | Clinical experience with new antiepileptic drugs: antiepileptic drugs in Europe. ( Loiseau, PJ, 1999) |
| " Subsequent determination of individual-specific DPH maintenance dosage and volume of distribution data suitable for use in routine therapeutic concentration management procedures." | 1.30 | Practical management of therapeutic diphenylhydantoin concentrations in children. ( Parkin, DP; Schoeman, JF; Seifart, HI; Smit, A, 1999) |
| " They were taking PHT in a dosage ranging from 100 to 300 mg daily, in mono or polytherapy regimen, during 1-5 previous years." | 1.30 | Phenytoin as the first option in female epileptic patients? ( da Silva, VR; Molinari, MA; Trevisol-Bittencourt, PC; Troiano, AR, 1999) |
| "We present the case of a patient that after chronic use of anticonvulsant drugs without proven epilepsy, developed Dupuytren's and Ledderhose's diseases." | 1.30 | [Dupuytren's and Ledderhose's diseases associated with chronic use of anticonvulsants. Case report]. ( Coral, P; Correa Neto, Y; Nóvak, EM; Teive, HA; Werneck, LC; Zanatta, A, 1999) |
| "Phenytoin (DPH) is a widely used anticonvulsant drug but a conclusive mode of action is not yet clear." | 1.29 | Effect of chronic administration of phenytoin on regional monoamine levels in rat brain. ( Lakshmana, KM; Meshkibaf, MH; Rao, BS; Subhash, MN, 1995) |
| "The medication regimens used to treat epilepsy are further complicated by the fact that most seizure medications are metabolized in the liver and have the potential for serious pharmacokinetic drug-drug interactions with many other medications." | 1.29 | Practical considerations in anticonvulsant therapy--Part 2. ( Cloyd, J; Garnett, WR; Holmes, GL; Meyer, MC; Schiffer, JR, 1995) |
| "Treatment with phenytoin did not influence the results." | 1.29 | Positron emission tomographic study of late-onset cryptogenic symptomatic seizures. ( Crevits, L; De Reuck, J; Decoo, D; Goethals, P; Lemahieu, I; Santens, P; Strijckmans, K; Van Maele, G, 1995) |
| "Routine clinical pharmacokinetic data collected from epileptic out-patients who received phenytoin (PHT) were analysed to estimate population pharmacokinetic parameters." | 1.29 | [NONMEM approach for estimating population pharmacokinetic parameters of phenytoin in Chinese epileptics]. ( Cai, MH; Chen, G; Chu, XM; Rui, JZ, 1995) |
| "Phenytoin-treated patients had a significant reduction in the mean IgA and IgG levels compared to healthy and epileptic controls (P < 0." | 1.29 | Humoral and cellular immune parameters in untreated and phenytoin-or carbamazepine-treated epileptic patients. ( Başaran, N; Ciğer, A; Hincal, F; Kansu, E, 1994) |
| "Trends in treatment of epilepsy in an institution for handicapped patients with epilepsy were investigated in a retrospective longitudinal study." | 1.29 | [Changes in drug therapy and in seizure frequency in an institution for epilepsy patients between 1971 and 1986]. ( May, T; Wohlhüter, M; Wolf, P, 1994) |
| " A review of published studies involving small numbers of elderly subjects or patients given phenytoin sodium, valproic acid, or carbamazepine demonstrates decreased protein binding and intrinsic clearance and increased half-life with advancing age." | 1.29 | Antiepileptics in the elderly. Pharmacoepidemiology and pharmacokinetics. ( Cloyd, JC; Lackner, TE; Leppik, IE, 1994) |
| "Diazepam was the first line treatment in 98 episodes, chlormethiazole and phenytoin were used in 27 and 18 episodes, respectively." | 1.29 | Status epilepticus: management and outcome of 107 episodes. ( Martin, PJ; Millac, PA, 1994) |
| " In this context, anticonvulsant and neurotoxic pharmacodynamic interactions between phenytoin (PHT) and valproate (VPA) were assessed in an experimental model in mice." | 1.29 | Pharmacodynamic interactions between phenytoin and valproate: individual and combined antiepileptic and neurotoxic actions in mice. ( Bourgeois, BF; Chez, MG; Knowles, WD; Pippenger, CE, 1994) |
| "Free phenytoin was determined in plasma from epileptic patients and the results were compared to those obtained by ultrafiltration." | 1.29 | Automated determination of free phenytoin in human plasma with on-line equilibrium dialysis and column-switching high-performance liquid chromatography. ( Andresen, AT; Rasmussen, KE; Rugstad, HE, 1993) |
| "Phenytoin is a potent inducer of carbamazepine metabolism." | 1.29 | Unmasking the significant enzyme-inducing effects of phenytoin on serum carbamazepine concentrations during phenytoin withdrawal. ( Abou-Elkair, M; Chapron, DJ; LaPierre, BA, 1993) |
| " Plasma concentrations of total phenytoin, unbound phenytoin, and the major metabolite of phenytoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin, were measured, and pharmacokinetic variables obtained before and after barbiturate therapy were compared." | 1.29 | Effect of barbiturate therapy on phenytoin pharmacokinetics. ( Abe, J; Asada, A; Fujimori, M; Kaji, A; Nishi, S; Oda, Y; Yoshida, N, 1993) |
| "Two protocols were used: assessment of seizures immediately after the completion of the kindling procedure and after the 2-week postkindling PTX-free period, as compared with acute PTX seizures." | 1.29 | Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models. ( Godlevsky, LS; Mazarati, AM; Shandra, AA; Vastyanov, RS, 1996) |
| "D-Cycloserine (DCS) is a high-efficacy partial agonist at the strychnine-insensitive glycine modulatory site within the N-methyl-D-aspartate (NMDA)-receptor/ionophore complex." | 1.29 | Influence of D-cycloserine on the anticonvulsant activity of phenytoin and carbamazepine against electroconvulsions in mice. ( Czuczwar, SJ; Roliński, Z; Wlaź, P, 1996) |
| " Thirty-six adult epileptic patients who had been receiving phenytoin for greater than 6 months without a recent change in dosage were assessed for signs of periodontal disease and gingival overgrowth." | 1.29 | Plasma and saliva concentrations of phenytoin and 5-(4-hydroxyphenyl)-5-phenylhydantoin in relation to the incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients. ( Ball, DE; Kamali, F; McLaughlin, WS; Seymour, RA, 1996) |
| "The duration of the vegetative state was 12 days, 15 days or about 4 months until death and was associated with corresponding stages of generalized ischemic brain damage." | 1.29 | Relationship between ischemic damage and concentrations of phenytoin and phenobarbital in the brain cortex of epileptic patients in vegetative state at death. ( Jürgens, U; Lahl, R; May, T; Rambeck, B; Schnabel, R, 1996) |
| "The seizures were predominantly clonic jerks accompanied by large spikes and slow waves lasting for 30-60s." | 1.29 | Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy. ( Satishchandra, P; Shankar, SK; Ullal, GR, 1996) |
| "Cerebral cavernous angioma (cavernoma) has previously been treated by resection for all presentations when surgically resectable." | 1.28 | Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases. ( Churchyard, A; Grainger, K; Khangure, M, 1992) |
| " Regular 2 weekly follow up for a minimum period of 2 months was done, after altering the drug dosage and bringing plasma level(s) within therapeutic range." | 1.28 | "An analysis of epileptic patients nonresponsive to drugs". ( Joshi, MV; Karande, SC; Kshirsagar, NA; Shah, PU, 1992) |
| " This equation predicts the AUC0-INF produced by a given tracer dose of drug will vary directly with C in drugs with nonlinear pharmacokinetic properties (i." | 1.28 | Bioavailability studies of drugs with nonlinear pharmacokinetics: I. Tracer dose AUC varies directly with serum concentration. ( Browne, TR; Evans, BA; Evans, JE; Greenblatt, DJ; Schumacher, GE; Szabo, GK, 1992) |
| " There was no calcitonin correlation with the anticonvulsant dosage or with the total doses ingested." | 1.28 | Long-term influence of anticonvulsant agents on calcitonin, parathyroid hormone and osteocalcin. ( Arias, JA; Cabranes, JA; Rico, H; Varela de Seijas, E, 1992) |
| " Since praziquantel, the drug used to treat neurocysticercosis, undergoes extensive liver first-pass metabolism, we carried out a prospective study to verify whether there was a decrease in oral bioavailability induced by carbamazepine and phenytoin." | 1.28 | Phenytoin and carbamazepine decreased oral bioavailability of praziquantel. ( Bittencourt, PR; Diekmann, HW; Fernandes, AG; Gracia, CM; Jung, W; Martins, R, 1992) |
| " It could be due to a lower bioavailability (F) of the tested phenytoin preparations and/or a higher volume of distribution (Vd) in Chinese." | 1.28 | Comparison on bioequivalence of four phenytoin preparations in patients with multiple-dose treatment. ( Huang, JD; Lai, ML; Tsai, JJ; Yang, YH, 1992) |
| "A simple and practical graphic method based on Bayesian feedback theory for predicting individual phenytoin dosage was evaluated." | 1.28 | A Bayesian graphic method for predicting individual phenytoin dosage schedule. ( Cai, WM; Chen, G; Chu, XM, 1991) |
| "Only one patient had a complete IgA deficiency." | 1.28 | Anti-IgA antibodies in epileptic patients with a low serum IgA concentration. ( Gilhus, NE; Hammarström, L, 1991) |
| " In order to define the minimal dosage of fentanyl required, the MD was titrated according to increases or decreases in the heart rate and/or mean arterial pressure exceeding 15 per cent of baseline ward values." | 1.28 | Anticonvulsant therapy increases fentanyl requirements during anaesthesia for craniotomy. ( Modica, PA; Spitznagel, EL; Tempelhoff, R, 1990) |
| " Eighty-four patients had been established on treatment with a single anticonvulsant drug (35 carbamazepine (CBZ), 30 sodium valproate (VPA), 19 phenytoin (PHT)) at unaltered dosage for the previous 3 months." | 1.28 | Cognitive function in adult epileptic patients established on anticonvulsant monotherapy. ( Brodie, MJ; Butler, E; Gillham, RA; Larkin, JG; Wiedmann, KD; Williams, N, 1990) |
| "1% seizure control rate), with adverse effects of sedation and intellectual depression." | 1.28 | Plasma level distribution, effect and toxicity of antiepileptic drugs among Ethiopian epileptics. ( Abebe, Y; Bekele, G; T'Haimanot, R, 1990) |
| "Paroxysmal kinesigenic choreoathetosis (PKC) is rare and has only recently been individualized (Kertesz, 1967)." | 1.28 | [Paroxysmal kinesigenic choreoathetosis: autonomic disease or reflex epilepsy?]. ( Bricout, JH; Cler, JM; Vercelletto, M; Vercelletto, P, 1990) |
| "When phenytoin was given with carbamazepine percentage (mean +/- SEM) protein binding was 87." | 1.28 | Serum protein binding of antiepileptic drugs in Sri Lankans. ( Joice, PD; Karunanayake, EH; Meijer, JW; Meinardi, H; Peiris, JB, 1990) |
| " The capability predicting individual phenytoin dosage was assessed by the retrospective analysis of data of 44 patients and the prospective analysis of 15 patients." | 1.28 | [Population kinetic program for Michaelis-Menten elimination]. ( Lü, M; Song, JF; Zhou, HW, 1990) |
| "Phenytoin treatment may impair the validity of the caffeine liver function test." | 1.28 | Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism. ( Büchsel, R; Kohl, D; Kreiten, K; Matern, S; Wietholtz, H; Zysset, T, 1989) |
| " These results support the increased use of dosing aids for PHT that may help clinicians more accurately choose PHT doses and estimate time to steady state." | 1.28 | Dosing accuracy of antiepileptic drug regimens as determined by serum concentrations in outpatient epilepsy clinic patients. ( Privitera, MD, 1989) |
| "The excess numbers of brain cancer were concentrated within 10 years of hospitalization (RR = 20." | 1.28 | Cancer among epileptic patients exposed to anticonvulsant drugs. ( Boice, JD; Fraumeni, JF; Jensen, JP; Olsen, JH, 1989) |
| "25 patients (27." | 1.28 | [Epileptic seizures in patients with a cerebrovascular infarction]. ( Burri, H; Karbowski, K; Schäffler, L, 1989) |
| " We found a noticeable relationship between conduction velocity slowing and daily dosage for CBZ only." | 1.27 | Anticonvulsant therapy and its possible consequences on peripheral nervous system: a neurographic study. ( Faedda, MT; Geraldini, C; Sideri, G, 1984) |
| " Pharmacokinetic interactions between antiepileptic drugs may lead to considerable fluctuation in plasma drug concentration, and monotherapy is often preferable." | 1.27 | Pharmacokinetics of antiepileptic drugs. ( Neuvonen, PJ; Tokola, RA, 1983) |
| "Phenytoin continues to be a very popular drug for most types of seizures, but carbamazepine, used adjunctively until recently, is effective as monotherapy for the control of partial seizures, particularly those of the complex partial variety." | 1.27 | Treatment of the nonconvulsive epilepsies. ( Dreifuss, FE, 1983) |
| "Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given." | 1.27 | [Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983) |
| "Phenobarbital may cause hyperactivity, behavioral problems, sedation, and even dementia; these effects are dose related to some extent." | 1.27 | Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy. ( Iivanainen, M; Savolainen, H, 1983) |
| " However, whereas toxic reactions following phenytoin and carbamazepine are characterised by a rather short duration of exposure before symptoms occur with accompanying clinical features of hypersensitivity, valproate-induced hepatic toxicity exhibits no signs of hypersensitivity and often occurs following prolonged exposure, speaking in favor of a metabolic aberration as the underlying cause." | 1.27 | Hepatic toxicity of antiepileptic drugs: a review. ( Bentsen, KD; Gram, L, 1983) |
| " Significant positive correlations were found between the dosage of CBZ, DPH, PMD and PB and both indices of enzyme induction." | 1.27 | A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. ( Hedges, A; Makki, KA; Perucca, E; Richens, A; Ruprah, M; Wilson, JF, 1984) |
| "Most electrically induced seizures involve forebrain structures, such as the amygdala or frontal cortex, but the following studies characterized a specific anatomic site in the inferior colliculus which generated seizure-like behavior after a single, low current electrical stimulation." | 1.27 | Electrically elicited seizures from the inferior colliculus: a potential site for the genesis of epilepsy? ( Breese, GR; Frye, GD; Greenwood, RS; McCown, TJ, 1984) |
| "The Mullen and Foster method was prospectively applied for individualizing phenytoin dosage in 24 epileptic patients." | 1.27 | Clinical application of the Mullen and Foster method for individualizing phenytoin dosage. ( Arnetoli, G; Bartoli, C; Donati-Cori, G; Messori, A; Muscas, GC; Silvano, R; Tendi, E; Valenza, T; Zaccara, G; Zappoli, R, 1984) |
| " Fifty-one percent of the 53 patients receiving phenytoin were completely controlled at either below or above the 10 to 20 micrograms/ml range, suggesting that individual dosage adjustment is preferably based on clinical judgment rather than numerical limits of published therapeutic ranges." | 1.27 | Therapeutic plasma levels of phenytoin, phenobarbital, and carbamazepine: individual variation in relation to seizure frequency and type. ( Haenel, F; Schmidt, D, 1984) |
| "Phenytoin treatment was associated with further decreases in serum IgA in patients with idiopathic epilepsy (p = 0." | 1.27 | Effects of phenytoin on man's immunity. Evaluation of changes in serum immunoglobulins, complement, and antinuclear antibody. ( Bardana, EJ; Craig, S; Davies, GH; Gabourel, JD, 1983) |
| "Phenytoin was administered intravenously to six adult epileptic patients in doses ranging from 500--1000 mg (equivalent to 5." | 1.27 | Acute effects of intravenous phenytoin on the frequency of inter-ictal spikes in man. ( Milligan, N; Oxley, J; Richens, A, 1983) |
| "Oxazepam was more than 93% bound to serum proteins, but the extent of binding was not significantly different between the two groups." | 1.27 | Oxazepam pharmacokinetics in patients with epilepsy treated long-term with phenytoin alone or in combination with phenobarbitone. ( Hawksworth, GM; Khir, AS; Petrie, JC; Scott, AK; Steele, WH, 1983) |
| "Most patients have quiescent seizure disorders and can manage well on monotherapy." | 1.27 | Reduction of polypharmacy for epilepsy in an institution for the retarded. ( Bennett, HS; Dunlop, T; Ziring, P, 1983) |
| " Due to the increase in tonic-clonic seizures after the initiation of folic acid (1 mg, orally) the sodium phenytoin dosage was increased by 130 mg until control was achieved." | 1.27 | Phenytoin and folic acid: individualized drug-drug interaction. ( Berg, MJ; Fischer, LJ; Rivey, MP; Schottelius, DD; Vern, BA, 1983) |
| "A Bayesian feedback technique for predicting phenytoin dosage was compared to other dosing methods." | 1.27 | Predicting phenytoin dosages using Bayesian feedback: a comparison with other methods. ( Ludden, TM; Murphy, MJ; Taylor, JW; Yuen, GJ, 1983) |
| " In epileptic patients, the plasma PHT concentrations were increased when dosage form was changed from the powder to 99%FG-F." | 1.27 | Comparison of bioavailability for phenytoin products prepared by wet granulation in normal subjects and epileptic patients. ( Hosaka, A; Ishikawa, N; Kohda, Y; Nakagawa, F; Nishihara, K; Saitoh, Y; Tamura, Z, 1983) |
| "Phenytoin treatment prevented the occurrence of convulsive and EEG seizures; however, lipid peroxidation was unaffected (16." | 1.27 | Effect of phenytoin and corticosteroids on seizures and lipid peroxidation in experimental posttraumatic epilepsy. ( Triggs, WJ; Willmore, LJ, 1984) |
| " Predictions are much more complicated when impaired bioavailability exists." | 1.27 | Influence of bioavailability on the calculated Michaelis-Menten parameters of phenytoin in children. ( Brand, N; Koren, G; MacLeod, SM, 1984) |
| " Further, for dogs given phenobarbital, there was a sixfold variation between dosage and achieved serum concentration, whereas dogs given primidone manifested even greater variability between dosage and serum concentration." | 1.27 | Serum concentrations and efficacy of phenytoin, phenobarbital, and primidone in canine epilepsy. ( Farnbach, GC, 1984) |
| "The application of a Bayesian feedback algorithm for phenytoin (PHT) dosing adjustments was modified empirically to take advantage of measurements of plasma unbound PHT concentrations in the estimation of Km values." | 1.27 | Use of plasma unbound drug concentrations in adjusting phenytoin doses. ( Bachmann, K; Forney, R; Voeller, K, 1984) |
| " After the first week of life, drug eliminating mechanisms mature and drug dosage requirements often increase dramatically." | 1.27 | Antiepileptic drug utilization in pediatric patients. ( Dodson, WE, 1984) |
| "Cimetidine can cause significant changes in phenytoin serum levels which may be manifested clinically." | 1.27 | Effect of cimetidine on phenytoin serum levels. ( Breland, BD; Jordan, JE; Mishra, SK; Salem, RB, 1983) |
| "When phenytoin was being reduced, more seizures appeared to originate from the left temporal lobe than from the right." | 1.27 | Falsely localizing ictal onsets with depth EEG telemetry during anticonvulsant withdrawal. ( Crandall, PH; Engel, J, 1983) |
| "Carbamazepine was the most effective to block SEA at concentrations of 1-15 microM." | 1.27 | Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices. ( Franceschetti, S; Hamon, B; Heinemann, U; Konnerth, A; Yaari, Y, 1985) |
| "Phenytoin was associated with the most frequent and highest enzyme elevations in both adult and pediatric patients." | 1.27 | Serum 5'-nucleotidase in patients receiving anti-epileptic drugs. ( Fortman, CS; Witte, DL, 1985) |
| " Frequency and extent of increased activity of gamma-GT were highly related to daily dosage in both preparations." | 1.27 | The influence of long-term anticonvulsant therapy with diphenylhydantoin and carbamazepine on serum gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase. ( Aldenhövel, HG, 1988) |
| " Frequency and extent of increased activity of gamma-GT were highly related to daily dosage in both preparations." | 1.27 | [Altered gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase serum activities in long-term anticonvulsive therapy--comparison of diphenylhydantoin and carbamazepine]. ( Aldenhövel, HG, 1988) |
| " These results show that barbiturates should not be first-choice drugs in patients who have a chronic disease such as epilepsy, and indicate a schedule for barbiturate withdrawal which is safe and independent of hospitalization or monitoring of antiepileptic drug serum concentrations." | 1.27 | Barbiturate-refractory epilepsy: safe schedule for therapeutic substitution. ( Bittencourt, PR; Gorz, AM; Silvado, CE, 1986) |
| "A man with lupus anticoagulant and a prothrombin deficiency was studied before and after cessation of treatment with phenytoin." | 1.27 | Concurrent lupus anticoagulants and prothrombin deficiency due to phenytoin use. ( Alperin, JB; Harrison, RL; Kumar, D, 1987) |
| "In particular, memory deficits, attentional problems, psychomotor slowing and reading and writing difficulties are highlighted, and the impact of the seizures, brain damage, and anticonvulsant drugs on cognitive function noted." | 1.27 | [Cognitive effects of antiepileptic drugs]. ( Trimble, R, 1987) |
| "Phenytoin levels were reduced to 37% of the original values, although the drug was given intravenously." | 1.27 | An interaction between cytostatic and anticonvulsant drugs. ( de Voogd-van der Straaten, I; Neef, C, 1988) |
| " In each patient, the average unbound fraction for a dosing interval increased with increase in sodium valproate dose." | 1.27 | Changes in clearance of sodium valproate with changes in dose. ( Bury, RW; Fullinfaw, RO; Kilpatrick, CJ; Moulds, RF, 1987) |
| " Thus, frequent phenytoin serum concentration determinations or a change in phenytoin dosing rate are probably not necessary after adding phenobarbital." | 1.27 | Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics. ( Browne, TR; Evans, BA; Evans, J; Greenblatt, DJ; Mikati, MA; Szabo, GK, 1988) |
| " In 48% of the patients the drug dosage had to be increased to combat the increased seizure frequency." | 1.27 | Serum phenytoin during pregnancy, labor and puerperium. ( Bardy, AH; Hiilesmaa, VK; Teramo, KA, 1987) |
| "Zonisamide (CI-912) is an experimental antiepileptic drug." | 1.27 | Comparative pharmacokinetics of zonisamide (CI-912) in epileptic patients on carbamazepine or phenytoin monotherapy. ( Buchanan, RA; Friel, PN; Levy, RH; McLean, JR; Ojemann, LM; Shastri, RA; Wilensky, AJ, 1986) |
| " The most common of these causes include malpractice of the dosage build-up in the absence of the clinical effect, polytherapy--not infrequently with drugs of the same chemical group, and insufficient attention to the potentiating drug interaction." | 1.27 | [Phenomenon of "paradoxical poisoning" during antiepileptic therapy]. ( Geladze, TSh, 1986) |
| " Data were excluded for patients who required dosage adjustments because of toxicity or seizures." | 1.27 | Effect of influenza vaccine on serum anticonvulsant concentrations. ( Fidone, GS; Jann, MW, 1986) |
| "Adverse gastrointestinal symptoms from milk may reduce the bioavailability of phenytoin." | 1.27 | Effect of simultaneously ingested milk on phenytoin bioavailability. ( Dasheiff, R; Dickinson, L; Dotson, R; Kang, H, 1985) |
| " The mechanisms responsible for these effects have not been elucidated and possibly include decreased bioavailability or compliance, increased metabolic clearance, or decreased plasma protein binding." | 1.27 | Effects of pregnancy on antiepileptic drug utilization. ( Levy, RH; Yerby, MS, 1985) |
| "According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony." | 1.27 | Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985) |
| "The % of gingival hyperplasia was significantly higher (P less than 0." | 1.27 | The effects of phenytoin and sodium valproate on the periodontal health of adult epileptic patients. ( Seymour, RA; Smith, DG; Turnbull, DN, 1985) |
| "Fifty-nine patients with chronic generalized tonic-clonic or partial seizures refractory to the maximally tolerated daily dosage of single-drug therapy with carbamazepine, phenytoin, phenobarbital, or primidone subsequently received single-drug therapy with another one of these primary anticonvulsant drugs." | 1.27 | Alternative single anticonvulsant drug therapy for refractory epilepsy. ( Richter, K; Schmidt, D, 1986) |
| "Crossover studies, following single oral doses given to 19 healthy volunteers were conducted to compare the bioavailability of three phenytoin preparations: DANTOIN and IDANTOIN (Teva, Israel) and EPANUTIN (Parke-Davis, USA)." | 1.27 | Bioavailability of phenytoin: comparison between three preparations. ( Ackerman, Z; Frumerman, I; Garty, M; Kitzes, R; Levy, M; Shved, A, 1985) |
| " The present stable-isotope methodology offered advantages for the estimation of absolute bioavailability of the oral phenytoin dose in patients, while normal therapy was continued and not withdrawn." | 1.27 | Stable-isotope methodology for the bioavailability study of phenytoin during multiple-dosing regimens. ( Baba, S; Kasuya, Y; Mamada, K; Matsukura, M, 1985) |
| "An animal model of central distal axonopathy following chronic administration of phenytoin is described." | 1.27 | Damage of Purkinje cell axons following chronic phenytoin administration: an animal model of distal axonopathy. ( Kirchgässner, N; Volk, B, 1985) |
| "Epileptiform abnormalities, seizures, or both were detected in 87 patients (17." | 1.27 | Ambulatory cassette EEG in clinical practice. ( Bridgers, SL; Ebersole, JS, 1985) |
| " It is concluded that if, in a given patient, the p-HPPH level corresponds to the value expected from the PHT dose, it can be assumed that compliance and bioavailability are adequate and that the dose does not exceed Vmax." | 1.27 | Michaelis-Menten kinetics and the steady-state serum phenytoin/hydroxyphenytoin ratio. ( Bourgeois, BF; Wad, N, 1985) |
| "Multiple sclerosis is a rare but not exceptional condition in children." | 1.27 | Multiple sclerosis in childhood: long term katamnestic investigations. ( Máttyus, A; Veres, E, 1985) |
| "Patient compliance can be improved by reducing the complexity of drug dosage and by better labeling, packaging and informational exchange." | 1.26 | Once-a-day drug regimen for psychiatric patients. ( Hasan, MK; Mooney, RP, 1981) |
| " A significant correlation was noted between the total dosage and duration of therapy with PHT and the reduction of motor conduction velocity in the posterior tibial nerve." | 1.26 | Peripheral neuropathy in children on long-term phenytoin therapy. ( Mochizuki, Y; Motomura, T; Ohkubo, H; Suyehiro, Y; Tanizawa, A, 1981) |
| " However, no adjustment of phenytoin dosage is warranted, unless clinically indicated, since the free phenytoin levels remain unchanged." | 1.26 | Interaction between phenytoin and valproate. ( Beran, RC; Sansom, LN; Schapel, GJ, 1980) |
| " This would be a manifestation of an independent Phenytoin effect in the high toxic dosage respectively in withdrawal." | 1.26 | [EEG in phenytoin intoxication (author's transl)]. ( Mayr, N; Wessely, P, 1981) |
| "The Michaelis-Menten pharmacokinetics and bioavailability of phenytoin were evaluated in children." | 1.26 | Plasma levels and pharmacokinetics of antipileptic drugs in children. ( Miura, H, 1981) |
| "Ictal and post-ictal confusional states of 24 h or more duration (up to 7-8 days) were noted in 11 patients (14%)." | 1.26 | Epileptic seizures in the elderly: II. Diagnostic problems. ( Caird, FI; Godfrey, JW; Roberts, MA, 1982) |
| "Phenytoin (PHT) binding was also determined for comparison." | 1.26 | Diurnal oscillations in plasma protein binding of valproic acid. ( Levy, RH; Ojemann, LM; Patel, IH; Venkataramanan, R; Viswanathan, CT, 1982) |
| " Reducing the dosage by 19 mg/kg (A to B) decreased VPA plasma levels by 6." | 1.26 | Monitoring free valproic acid in epilepsy patients medicated with coanticonvulsants. ( Haidukewych, D; Rodin, EA, 1982) |
| "Analysis of the recurrence of seizures suggested that the first year of treatment may be crucial in determining the long-term prognosis." | 1.26 | Early prognosis of epilepsy. ( Reynolds, EH; Shorvon, SD, 1982) |
| "Since epilepsy is a long-standing condition lasting for years to decades, short-spanned cross-sectional observations are often misleading." | 1.26 | Therapeutic concentration of antiepileptic drugs and the severity of epileptogenesis. ( Kakegawa, N; Seino, M, 1982) |
| "The prevalence of treated epilepsy in Wellington is 4." | 1.26 | Prescribing patterns for epilepsy. ( Johnson, RH; Lambie, DG; Stanaway, L, 1981) |
| "In the preceding articles, a number of pharmacokinetic concepts have been introduced, and a number of parameters such as plasma half-life, volume of distribution and clearance have been defined." | 1.26 | Elementary pharmacokinetics in clinical practice. 3: Practical pharmacokinetic applications. ( Paxton, JW, 1981) |
| "5%) cases without correlation with the dosage (D in mg/kg)." | 1.26 | Comparative study of bioavailabilities of different phenytoin preparations. ( Fukuyama, Y; Goto, T; Kitahara, H, 1982) |
| "0% at discharge) versus polytherapy; degree of correspondence between recommended and observed dosage regimens (undertreatment being a more common problem than excessive dosing); and reporting of side effects." | 1.26 | Quality of care of epilepsy in Italy: multi-hospital survey of diagnosis and treatment of 1104 epileptic patients. ( Beghi, E; Sasanelli, F; Spagnoli, A; Tognoni, G, 1982) |
| "Among those who showed an IgA deficiency during phenytoin treatment, 14 had the antigen HLA-A2." | 1.26 | HLA antigens in epileptic patients with drug-induced immunodeficiency. ( Aarli, JA; Gilhus, NE; Thorsby, E, 1982) |
| "The bioavailability of phenytoin from rapid release capsule and oral solution formulations relative to that of a slow release capsule formulation was assessed in five patients who had participated in a three-way crossover study performed at steady state." | 1.26 | Rapid and slow release phenytoin in epileptic patients at steady state: assessment of relative bioavailability utilizing Michaelis-Menten parameters. ( Gumnit, RJ; Leppik, IE; Pepin, SM; Sawchuk, RJ, 1982) |
| " The concentration-dependence of the t50% provided the basis for less frequent dosing than one would expect from previous studies of PHT half-life in children with low concentrations." | 1.26 | Phenytoin elimination in childhood: effect of concentration-dependent kinetics. ( Dodson, WE, 1980) |
| " Once two phenytoin serum levels were obtained on two different dosage regimens, a table of future doses and predicted serum levels was calculated and plotted on a graph." | 1.26 | Predicting individual phenytoin serum levels of patients seen in a private office practice. ( Gonzalez, MA; Robinson, FC; Warner, RN, 1981) |
| " Six methods of predicting phenytoin dosage or plasma concentrations--one equation, two nomograms, and three graphs--were compared to actual phenytoin doses and corresponding steady-state serum levels." | 1.26 | Clinical utility of six methods of predicting phenytoin doses and plasma concentrations. ( Bruni, J; Murphy, JE; Stewart, RB, 1981) |
| "Phenytoin half-life was 31." | 1.26 | Rapid infusion of phenytoin sodium loading doses. ( Doering, PL; Lee, C; Salem, RB; Wilder, BJ; Yost, RL, 1981) |
| " The long-term administration of anticonvulsant drugs was monitored by measurement of the serum concentrations of phenytoin and primidone, by seizure anamnesis, and by repeated EEG investigations." | 1.26 | Chromosomal investigations in epileptic children during long-term therapy with phenytoin or primidone. ( Esser, KJ; Habedank, M; Kotlarek, F; Mühler, E; Mühler, U, 1981) |
| "The phenytoin treated children did not differ with respect to the concentrations of IgA in saliva in comparison to the controls." | 1.26 | Phenytoin and IgA concentrations in plasma and saliva in epileptic children. ( Falk, O; Modéer, T; Rane, A; Tomson, G, 1981) |
| "Carbamazepine was given to 152 patients who were receiving multiple drug therapy for uncontrolled seizures." | 1.26 | Role of carbamazepine in reducing polypharmacy in epilepsy. ( Maheshwari, MC; Padmini, R, 1981) |
| "Reversible cerebellar dysfunction is a common manifestation of acute phenytoin toxicity." | 1.26 | [Diphenylhydantoin, epilepsy, cerebellar atrophy--histological and electron microscope examinations (author's transl)]. ( Breiden-Arends, C; Gullotta, F, 1981) |
| " These observations suggest that dosage regimen adjustment of phenytoin based on the averaged Vmax in a given pediatric age group rather than the Km is recommended for a particular patient with inadequate therapeutic control of seizure or toxicity of this drug." | 1.26 | Apparent Michaelis-Menten kinetic parameters of phenytoin in pediatric patients. ( Chiba, K; Ishizaki, T; Minagawa, K; Miura, H, 1980) |
| "Subtherapeutic phenytoin serum levels and loss of seizure control occurred in a 31-year-old man due to decreased bioavailability of oral drug." | 1.26 | Reduced seizure control due to spoiled phenytoin capsules. ( Cloyd, JC; Gumnit, RJ; Lesar, TS, 1980) |
| " Within the therapeutic range, small increments in dosage resulted in large increments in plasma DPH levels, and in the postpartum period high levels of DPH were encountered if the dosage was not reduced." | 1.26 | Phenytoin metabolism in pregnancy. ( Emery, MG; Kochenour, NK; Sawchuk, RJ, 1980) |
| "phenytoin were evaluated." | 1.26 | Neuropsychological correlates of anticonvulsants and epileptiform discharges in adult epileptics. ( Dodrill, CB; Wilkus, RJ, 1978) |
| "Patients with chronic renal failure had low plasma total, but disproportionately high plasma free, drug concentrations indicating impaired protein binding." | 1.26 | Salivary phenytoin concentrations in epilepsy and in chronic renal failure. ( Jones, NF; Reynolds, F; Smith, SE; Ziroyanis, PN, 1976) |
| "Phenytoin dosage was increased to study the effect on the frequency of seizures and the serum concentrations of phenytoin and phenobarbitone." | 1.26 | Therapeutic and pharmacokinetic effects of increasing phenytoin in chronic epileptics on multiple drug therapy. ( Johnson, RH; Lambie, DG; Nanda, RN; Shakir, RA, 1976) |
| "The phenytoin plasma levels were measured in 45 epileptic patients whose only treatment was phenytoin." | 1.26 | In vivo interaction of anticonvulsant drugs. The mathematical correlation of plasma levels of anticonvulsant drugs in epileptic patients. ( Abarbanel, J; Eylath, U; Herishanu, Y; Rosenberg, P, 1978) |
| "Hirsutism was rare in black patients." | 1.26 | Effects of diphenylhydantoin in 41 epileptics institutionalized since childhood. ( Herberg, KP, 1977) |
| "Carbamazepine has recently been introduced for the treatment of generalized tonic-clonic and partial seizures." | 1.26 | Recent advances in drug therapy for epilepsy. ( Bruni, J, 1979) |
| "The mothers of children who developed cancer reported about 25% more illnesses during pregnancy than mothers of healthy control children." | 1.26 | Childhood cancer and drugs in pregnancy. ( Draper, GJ; Sanders, BM, 1979) |
| "Transient hyperkinesia was observed in a 16-year-old epileptic and mentally retarded patient after a single intravenous perfusion of diphenylhydantoin (DPH)." | 1.26 | Transient hyperkinesia after a single intravenous perfusion of diphenylhydantoin. Report of a case associated with nontoxic plasma levels of diphenylhydantoin. ( Courjon, J; Dalery, J; de Villard, R; Mauguière, F, 1979) |
| " The majority of the patients receiving Comital-L tablets showed low serum levels of phenytoin and high serum levels of phenobarbital, while patients treated with the usual daily dosage of Hydantol-F tablets showed adequate therapeutic serum levels of both phenytoin and phenobarbital." | 1.26 | Serum levels of phenytoin and phenobarbital in epileptic patients treated with mixture antiepileptic tablets, Comital-L or Hydantol-F. ( Hattori, M; Kazamatsuri, H, 1979) |
| "The effect of dosage schedules on plasma drug levels was evaluated in two groups of ambulant epileptic patients, whose treatment with diphenylhydantoin (DPH) or phenobarbital (PB) had been simplified by reducing the daily frequency of the dosage regimens." | 1.26 | Effectiveness of simplified dosage schedules on the management of ambulant epileptic patients. ( Galli, A; Zaccara, G, 1979) |
| " The bioavailability of a brand of phenytoin tablets used in Finland was improved in 1976." | 1.26 | Effect of increased bioavailability of phenytoin tablets on serum phenytoin concentration in epileptic out-patients. ( Bardy, A; Lehtovaara, R; Neuvonen, PJ, 1979) |
| "Rhythmic horizontal nystagmus occurred in 7 patients, and only at extreme (40 degrees, 50 degrees) later gaze in 6 of these." | 1.26 | Conjugate lateral gaze nystagmus and free phenytoin concentrations in plasma: lack of correlation. ( Downes, H; Olsen, GD; Riker, WK; Smith, B, 1978) |
| " Monitoring drug levels and electroencephalograms appears to be the method of choice for ensuring safe and effective medication in intractable epilepsy." | 1.26 | Electroencephalography and phenytoin toxicity in mentally retarded epileptic patients. ( Helle, EP; Iivanainen, M; Seppäläinen, AM; Viukari, M, 1978) |
| " Although phenytoin dosage remained relatively constant, plasma phenytoin concentrations during pregnancy were significantly lower than nonpregnant concentrations." | 1.26 | Hematologic effects of phenytoin therapy during pregnancy. ( Ramsay, RE; Strauss, RG; Wilder, BJ; Willmore, LJ, 1978) |
| " Mean saliva phenytoin concentrations did not differ significantly between the two treatment settings and were low largely because of the low mean dosage prescribed." | 1.26 | Compliance with anticonvulsant therapy in a hospital clinic and in the community. ( Dollery, CT; Mucklow, JC, 1978) |
| " When clinically indicated the daily dosage rate was adjusted by 50 mg steps until a serum concentration of 10--20 mg/l was produced." | 1.26 | Individual variation in daily dosage requirements for phenytoin sodium in patients with epilepsy. ( Barot, MH; Grant, RH; Maheendran, KK; Mawer, GE; Woodcock, BG, 1978) |
| " Monitoring plasma concentrations may lead to adaptations of the choice of the drug and of the dosage regimen." | 1.26 | Kinetics of drug interactions in the treatment of epilepsy. ( Guelen, P; Knop, H; Schobten, F; van der Kleijn, E; Vree, T; Westenberg, H, 1978) |
| "The phenytoin therapy was administered as 50 mg chewable Infatabs tablets in a single morning dose of 200 mg." | 1.26 | Comparison of serum phenytoin levels in epileptic patients who swallowed their phenytoin tablets with or without previous chewing. ( Bielmann, P; Levac, T, 1978) |
| "Free phenytoin levels were determined in a group of patients with renal disease treated by hemodialysis or transplantation and in epileptic patients who were otherwise healthy." | 1.26 | Correlation between red cell and free plasma phenytoin levels in renal disease. ( Gonda, A; Harvey, CD; Leppik, IE; Sherwin, AL, 1976) |
| "Gingival hyperplasia was studied in 13 boys with epilepsy living in a state hospital." | 1.26 | The effect of oral physiotherapy on dilantin gingival hyperplasia. ( Bibby, BG; Hawes, RR; King, DA, 1976) |
| "The present study investigated order and temporal spacing interactions of phenytoin and phenobarbital in terms of plasma levels during multiple dosing in monkeys." | 1.26 | Interactions of phenytoin and phenobarbital in terms of order and temporal spacing of administration in monkeys. ( Farquhar, JS; Levy, RH; Lockard, JS; Uhlir, V, 1976) |
| "Two methods for arriving at optimum, individual phenytoin dosage regimens have been evaluated in 12 patients." | 1.26 | Individualization of phenytoin dosage regimens. ( Allen, JP; Hoffman, SF; Lalka, D; Ludden, TM; McNay, JL; Nappi, JM; Valutsky, WA; Vicuna, AV; Wallace, JE, 1977) |
| " Dosage adjustments of DPH in patients were not associated with major changes in the plasma level of unconjugated 4-OH-DPH." | 1.26 | Plasma concentrations of 5-(4-hydroxyphenyl)-5-phenylhydantoin in phenytoin-treated patients. ( Garle, M; Hoppel, C; Rane, A; Sjöqvist, F, 1977) |
| " This indicates that long-term use of phenytoin does not cause a clinically significant state of folate deficiency, unless some other contributing factors are present." | 1.26 | Long-term of phenytoin: Effects on whole blood and red cell folate and haematological parameters. ( Knuutila, S; Tammisto, P; Tontti, K; Weber, TH, 1977) |
| " Intravenous injection of 250 mg phenytoin followed by infusion of 750 mg phenytoin in a mean dosage of 1." | 1.26 | [Plasma concentrations after injection or infusion of phenytoin (author's transl)]. ( Schmidt, D; Vogel, A, 1977) |
| "The possibility of treating status epilepticus by altering the orally administered therapy and leaving parenteral therapy for such cases with progressive impairment of consciousness and/or neuvoregetative disorders was indicated." | 1.26 | [Status epilepticus in Lennox-Gastaut syndrome; therapeutic aspects]. ( Lison, MP; Speciali, JG, 1977) |
| " The incidence increased with the duration of epilepsy and is probably a sequel to long-term administration of phenobarbitone." | 1.26 | Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants. ( Critchley, EM; Hayward, HW; Owen, VM; Vakil, SD, 1976) |
| "Phenytoin is a central anticholinergic agent and a central stimulant of serotonin, and may induce movement disorders as a result of altering these neurotransmitters in the brain." | 1.26 | Phenytoin-induced dystonia and choreoathetosis in two retarded epileptic children. ( Chalhub, EG; Devivo, DC; Volpe, JJ, 1976) |
| "A 28-year-old male of progressive myoclonus epilepsy was reported, who had showed a gradual progression in myoclonus, mental retardation and cerebellar symptoms, and had been treated with a large dosage of diphenylhydantoin." | 1.26 | A neuropathological case-study of myoclonus epilepsy. ( Ikeda, K; Ikeda, S; Namba, M; Nishikubo, M; Yoshimura, T, 1976) |
| " prescribing too low a dosage (the average dose in the adult is 5 mg/kg/day) or lack of cooperation by the patient who either takes the drug irregularly or fails to take it at all." | 1.26 | [Determination of plasma phenytoine and treatment of epileptics]. ( De Crousaz, G, 1976) |
| " Subtherapeutic levels appear to be due to inadequate dosage adjustment." | 1.26 | The necessity of drug level monitoring in anticonvulsant drug therapy. ( Bailey, DG; Davis, HL; Johnson, GE; Wilson, TW, 1976) |
| "In addition to the rate of recurrences, especially oral hygiene, existing bite abnormalities and the degree of mental retardation were considered." | 1.26 | [Prospects of surgical treatment in hydantoin-induced gingival hyperplasia]. ( Wörle, M, 1976) |
| " More common toxic effects were not noted on initial evaluation of the patient." | 1.26 | Acute athetosis as a result of phenytoin toxicity in a child. ( Marks, RE; Zinsmeister, S, 1976) |
| "In two patients, IgA deficiency developed within two to three months of treatment." | 1.26 | Drug-induced IgA deficiency in epileptic patients. ( Aarli, JA, 1976) |
| " Monitoring serum phenytoin levels during chronic therapy is an invaluable therapeutic aid, enabling dosage adjustments to be made in order to achieve a level within the therapeutic range." | 1.25 | A study of the pharmacokinetics of phenytoin (diphenylhydantoin) in epileptic patients, and the development of a nomogram for making dose increments. ( Richens, A, 1975) |
| "Steady-state serum-phenytoin levels were measured in five patients whose phenytoin dosage was changed three or more times for therapeutic purposes." | 1.25 | Serum-phenytoin levels in management of epilepsy. ( Dunlop, A; Richens, A, 1975) |
| "Phenytoin produced a lower serum level than the same dose of its sodium salt." | 1.25 | Systematic determination of the serum phenytoin level as an aid in the management of children with epilepsy. ( Gamstorp, I; Lilienberg, G; Norell, E, 1975) |
| " (3) Use of well-standardized, yet simplified, mental performance tests in combination with changes in the dosage of medication can help in reaching a compromise between acceptable seizure control and avoidance of excessive slowing of mental activity." | 1.25 | Effects of different dosages of anticonvulsant drugs on mental performance in patients with chronic epilepsy. ( Dekaban, AS; Lehman, EJ, 1975) |
| "A tonic-clonic seizure occured after the infusion of 14." | 1.25 | Harmful effect of megadoses of vitamins: electroencephalogram abnormalities and seizures induced by intravenous folate in drug-treated epileptics. ( Butterworth, CE; Ch'ien, LT; Krumdieck, CL; Scott, CW, 1975) |
| "A patient developed disseminated intravascular coagulation with purpura fulminans 1 month after starting Dilantin therapy for a seizure disorder." | 1.25 | Dilantin-induced disseminated intravascular coagulation with purpura fulminans. A case report. ( Chassin, MR; Guze, LB; Targan, SR, 1975) |
| "Phenytoin levels were measured using GLC and magnesium levels by atomic absorption spectrophotometry." | 1.25 | Serum magnesium levles in patients treated with phenytoin. ( Blyth, A; Stewart, MJ, 1975) |
| " All patients were stabilized on diphenylhydantoin alone, and assessment of this drug by gas-liquid chromatography provided a basis for dichotomizing the group into High and Low drug groups, both with and without toxic patients." | 1.25 | Diphenylhydantoin serum levels, toxicity, and neuropsychological performance in patients with epilepsy. ( Dodrill, CB, 1975) |
| "Successful treatment of partial complex seizures (and the epilepsies in general) is a process of management over time and involves several factors." | 1.25 | Management of the difficult patient with complex partial seizures. ( Booker, HE, 1975) |
| "Phenytoin therapy was associated with low immunoglobulin A (21%), failure of antibody response to Salmonella typhi antigen (9%), absence of delayed hypersensitivity (D." | 1.25 | Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin). ( Burness, FR; Forbes, IJ; Rischbieth, RH; Sorrell, TC, 1971) |
| "Blood phenytoin (diphenylhydantoin) concentrations were measured after each dosage change in 12 epileptic patients who were given increasing oral doses of phenytoin." | 1.25 | Effect of dosage increments on blood phenytoin concentrations. ( Bochner, F; Eadie, MJ; Hooper, WD; Tyrer, JH, 1972) |
| "The investigation and treatment of osteomalacia are described in four patients with epilepsy treated with long-term anticonvulsant therapy." | 1.25 | Osteomalacia with long-term anticonvulsant therapy in epilepsy. ( Dent, CE; Richens, A; Rowe, DJ; Stamp, TC, 1970) |
| " Hypocalcaemia was related to high dosage of anticonvulsant drugs, to multiple drug therapy, and to the use of individual anticonvulsant drugs in the following order, with decreasing order of importance: pheneturide, primidone, phenytoin, phenobarbitone." | 1.25 | Disturbance of calcium metabolism by anticonvulsant drugs. ( Richens, A; Rowe, DJ, 1970) |
| " Reduction of phenytoin dosage relieved the intoxication in all patients." | 1.25 | Outbreak of anticonvulsant intoxication in an Australian city. ( Eadie, MJ; Hooper, WD; Sutherland, JM; Tyrer, JH, 1970) |
Research
Studies (2,565)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1608 (62.69) | 18.7374 |
| 1990's | 402 (15.67) | 18.2507 |
| 2000's | 254 (9.90) | 29.6817 |
| 2010's | 238 (9.28) | 24.3611 |
| 2020's | 63 (2.46) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Conley, JD | 1 |
| Kohn, H | 1 |
| Poupaert, JH | 1 |
| Vandervorst, D | 1 |
| Guiot, P | 1 |
| Moustafa, MM | 1 |
| Dumont, P | 1 |
| Flaherty, PT | 1 |
| Greenwood, TD | 1 |
| Manheim, AL | 1 |
| Wolfe, JF | 1 |
| Anger, T | 1 |
| Madge, DJ | 1 |
| Mulla, M | 1 |
| Riddall, D | 1 |
| Ragavendran, JV | 1 |
| Sriram, D | 1 |
| Kotapati, S | 1 |
| Stables, J | 1 |
| Yogeeswari, P | 1 |
| Alam, O | 1 |
| Mullick, P | 1 |
| Verma, SP | 1 |
| Gilani, SJ | 1 |
| Khan, SA | 1 |
| Siddiqui, N | 2 |
| Ahsan, W | 1 |
| Azam, F | 1 |
| El-Gnidi, BA | 1 |
| Alkskas, IA | 1 |
| He, X | 1 |
| Qiu, G | 2 |
| Yang, J | 4 |
| Xiao, Y | 1 |
| Wu, Z | 1 |
| Hu, X | 1 |
| Dawidowski, M | 3 |
| Herold, F | 2 |
| Chodkowski, A | 2 |
| Kleps, J | 2 |
| Szulczyk, P | 1 |
| Wilczek, M | 1 |
| Prakash, CR | 1 |
| Raja, S | 1 |
| Tripathi, L | 1 |
| Kumar, P | 2 |
| Singh, R | 1 |
| Stables, JP | 1 |
| McComsey, DF | 1 |
| Smith-Swintosky, VL | 1 |
| Parker, MH | 1 |
| Brenneman, DE | 1 |
| Malatynska, E | 1 |
| White, HS | 3 |
| Klein, BD | 1 |
| Wilcox, KS | 1 |
| Milewski, ME | 1 |
| Herb, M | 1 |
| Finley, MF | 1 |
| Liu, Y | 2 |
| Lubin, ML | 1 |
| Qin, N | 1 |
| Reitz, AB | 1 |
| Maryanoff, BE | 1 |
| Chońska, J | 1 |
| Mika, W | 1 |
| Turło, J | 1 |
| Kumari, S | 1 |
| Mishra, CB | 1 |
| Tiwari, M | 1 |
| Tanaka, T | 1 |
| Yajima, N | 1 |
| Tanitame, A | 1 |
| Kiyoshi, T | 1 |
| Miura, Y | 1 |
| Ayati, A | 1 |
| Emami, S | 1 |
| Foroumadi, A | 1 |
| Shervani, S | 1 |
| Madden, W | 1 |
| Gleason, LJ | 1 |
| Marefi, A | 1 |
| Srour, M | 1 |
| John, S | 1 |
| Canyuk, B | 1 |
| Anand, TCV | 1 |
| Sukasem, C | 1 |
| Pattharachayakul, S | 1 |
| Ashraf, Z | 1 |
| Farhat, S | 1 |
| Rather, MY | 1 |
| Arabacı Tamer, S | 1 |
| Koyuncuoğlu, T | 1 |
| Karagöz Köroğlu, A | 1 |
| Akakın, D | 1 |
| Yüksel, M | 1 |
| Yeğen, BÇ | 1 |
| Fong, SL | 1 |
| Lim, KS | 1 |
| Hariraj, V | 1 |
| Lee, SC | 1 |
| Wo, WK | 1 |
| Ramli, A | 1 |
| Ho, JH | 1 |
| Lai, PSM | 1 |
| Ng, WL | 1 |
| Nevitt, SJ | 4 |
| Sudell, M | 3 |
| Cividini, S | 1 |
| Marson, AG | 15 |
| Tudur Smith, C | 7 |
| Wu, H | 1 |
| Liu, J | 1 |
| Qian, F | 1 |
| Wang, Y | 2 |
| Guan, S | 1 |
| Verdez, S | 1 |
| Thomas, Q | 1 |
| Garret, P | 1 |
| Verstuyft, C | 1 |
| Tisserant, E | 1 |
| Vitobello, A | 1 |
| Mau-Them, FT | 1 |
| Philippe, C | 1 |
| Bardou, M | 1 |
| Luu, M | 1 |
| Bourredjem, A | 1 |
| Callier, P | 1 |
| Thauvin-Robinet, C | 1 |
| Picard, N | 1 |
| Faivre, L | 1 |
| Duffourd, Y | 1 |
| Rajendran, P | 1 |
| Prabath, I | 1 |
| Rani, J | 1 |
| Han, Y | 1 |
| Zhong, R | 1 |
| Guo, X | 1 |
| Cai, M | 1 |
| Lin, W | 1 |
| Haris, A | 2 |
| Bachour, K | 1 |
| Hopkins, RB | 1 |
| Tarride, JE | 1 |
| Keezer, MR | 1 |
| Panda, SP | 1 |
| Dhurandhar, Y | 1 |
| Agrawal, M | 1 |
| D'Onofrio, G | 2 |
| Riva, A | 2 |
| Amadori, E | 2 |
| Lattanzi, S | 1 |
| Rose, K | 1 |
| Verrotti, A | 1 |
| Striano, P | 3 |
| Moratalla-Navarro, F | 1 |
| Moreno, V | 1 |
| López-Simarro, F | 1 |
| Barceló, ME | 1 |
| Aguado, A | 1 |
| Tomson, T | 10 |
| Battino, D | 4 |
| Bromley, R | 2 |
| Kochen, S | 1 |
| Meador, KJ | 5 |
| Pennell, PB | 5 |
| Thomas, SV | 2 |
| LoPinto-Khoury, C | 1 |
| Soto-Insuga, V | 1 |
| González-Alguacil, E | 1 |
| García-Peñas, JJ | 1 |
| Borowicz-Reutt, K | 2 |
| Banach, M | 4 |
| Roberti, R | 1 |
| Vari, MS | 1 |
| De Giorgis, V | 1 |
| Cerminara, C | 1 |
| Specchio, N | 1 |
| Pietrafusa, N | 1 |
| Tombini, M | 1 |
| Assenza, G | 1 |
| Cappanera, S | 1 |
| Marini, C | 1 |
| Rasmini, P | 1 |
| Veggiotti, P | 1 |
| Zara, F | 2 |
| Russo, E | 2 |
| Dorji, T | 1 |
| Wangmo, S | 1 |
| Tenzin, K | 1 |
| Jamtsho, S | 1 |
| Pema, D | 1 |
| Chhetri, B | 1 |
| Nirola, DK | 2 |
| Dhakal, GP | 1 |
| Guan, Q | 1 |
| Wang, X | 6 |
| Cao, D | 1 |
| Li, M | 1 |
| Luo, Z | 1 |
| Mao, X | 1 |
| Zhou, Z | 1 |
| Li, K | 1 |
| Guo, Y | 1 |
| Liu, P | 1 |
| Chen, Q | 1 |
| Fan, H | 1 |
| Sun, T | 1 |
| Jiang, C | 1 |
| Liu, X | 1 |
| Peng, X | 1 |
| Du, Y | 2 |
| Xu, Q | 1 |
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| Lempp, R | 1 |
| Eisenmann, M | 1 |
| Friedel, B | 1 |
| Lindall, AW | 1 |
| Livingston, HL | 1 |
| Chaud, A | 1 |
| Asi, AE | 1 |
| Espejo, H | 1 |
| Navarrete, J | 1 |
| Segovia, V | 1 |
| Scott, JE | 1 |
| Spilker, B | 1 |
| Yeager, CL | 1 |
| Hirschmann, J | 1 |
| Höglmeier, H | 1 |
| Wenzel, U | 1 |
| Szeberenyi, S | 1 |
| Tacconi, MT | 1 |
| Forster, FM | 1 |
| Paulsen, WA | 1 |
| Takamizawa, M | 1 |
| Kobayashi, T | 1 |
| Otaka, T | 1 |
| Fukuzawa, H | 1 |
| Olsesen, OV | 1 |
| Kramer, MD | 1 |
| Goulding, R | 1 |
| Wise, S | 1 |
| Regli, F | 1 |
| Guggenheim, P | 1 |
| Haynes, J | 2 |
| Molina, P | 1 |
| Madoz, P | 1 |
| Kane, FJ | 1 |
| Lauriault, CD | 1 |
| Berger, H | 1 |
| Olesen, V | 1 |
| Winters, W | 1 |
| McDowell, FH | 1 |
| Schumacher, GA | 1 |
| Campbell, EW | 1 |
| Young, JD | 1 |
Clinical Trials (22)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Precision IFX: Using a Pharmacokinetic Dashboard to Optimize and Individualize Infliximab Dosage for Pediatric Inflammatory Bowel Disease Patients[NCT02624037] | 189 participants (Actual) | Interventional | 2015-01-31 | Completed | |||
| Pilot Study of Seizure Prophylaxis With Levetiracetam in Aneurysmal Subarachnoid Hemorrhage[NCT01935908] | Phase 4 | 0 participants (Actual) | Interventional | 2013-05-31 | Withdrawn (stopped due to no funding) | ||
| A Double-blind Trial Comparing the Efficacy, Tolerability and Safety of Monotherapy Topiramate Versus Phenytoin in Subjects With Seizures Indicative of New Onset Epilepsy[NCT00210782] | Phase 3 | 262 participants (Actual) | Interventional | 2004-06-30 | Completed | ||
| A Retrospective Study to Evaluate Retention Rate of Topiramate With That of Levetiracetam and Oxcarbazepine in a Long-term Epilepsy Treatment[NCT02098941] | 2,500 participants (Anticipated) | Observational | 2014-03-31 | Recruiting | |||
| Efficacy and Tolerability of Low vs. Standard Daily Doses of Antiepileptic Drugs in Newly Diagnosed, Previously Untreated Epilepsy (STANDLOW). A Multicenter, Randomized, Single-blind, Parallel-group Trial[NCT03689114] | Phase 4 | 374 participants (Anticipated) | Interventional | 2020-01-07 | Not yet recruiting | ||
| A Clinical Pharmacokinetics Comparing Brand and Generic Topiramate in Epilepsy Patients : A Open-label,Randomised, Three-period Crossover Study[NCT02113787] | 24 participants (Actual) | Interventional | 2014-02-28 | Completed | |||
| Pilot: Levetiracetam to Prevent Post-Traumatic Epilepsy[NCT01463033] | Phase 2 | 126 participants (Actual) | Interventional | 2005-04-30 | Completed | ||
| Neurodevelopmental Effects of Antiepileptic Drugs II: the NEAD Study[NCT00021866] | 331 participants (Actual) | Observational | 2000-09-30 | Completed | |||
| Verapamil as Adjunctive Seizure Therapy for Children and Young Adults With Dravet Syndrome[NCT01607073] | Phase 2 | 2 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency[NCT01379469] | Phase 2 | 20 participants (Actual) | Interventional | 2012-01-31 | Terminated | ||
| Measurement of Risperidone and 9-Hydroxyrisperidone in Plasma and Saliva[NCT00395499] | 19 participants | Observational | 2001-05-31 | Completed | |||
| Single-dose Potassium Supplementation in ADHD Patients With Lidocaine Ineffectiveness[NCT03563573] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2018-07-01 | Enrolling by invitation | ||
| Prevalence of Lidocaine Ineffectiveness in Those With Hard-to-treat ADHD[NCT04167189] | Early Phase 1 | 28 participants (Actual) | Interventional | 2018-01-20 | Completed | ||
| Reliability Testing of a Non-invasive, Pain-free, Taste-based Assessment Approach to Lidocaine Effectiveness[NCT03680885] | Early Phase 1 | 20 participants (Actual) | Interventional | 2019-08-01 | Completed | ||
| Assessing the Frequency of Lidocaine Ineffectiveness in the General Population vs. Males With ADHD, and Females With ADHD, With or Without PMS[NCT03676725] | Early Phase 1 | 90 participants (Actual) | Interventional | 2019-08-14 | Completed | ||
| Diaphragmatic Breathing and Heart Rate Variability Training for Improving Hypertension in Fragile X Associated Tremor/Ataxia[NCT03816540] | Phase 3 | 20 participants (Actual) | Interventional | 2018-05-01 | Completed | ||
| A Prospective Study on the Treatment of Burning Mouth Syndrome With Integration of Traditional Chinese Medicine(TCM) and Western Medicine Based on TCM Syndrome Differentiation[NCT04189367] | Phase 3 | 80 participants (Anticipated) | Interventional | 2020-06-20 | Not yet recruiting | ||
| The Diagnosis and Management of Patients With Epilepsy: Nationwide, Multicenter Study of Recordings for the Diagnosis and Management of Patients With Epilepsy and Treatment With Levetiracetam in Daily Clinical Practice in Greece[NCT02356731] | 450 participants (Actual) | Observational | 2015-03-31 | Completed | |||
| An Open Prospective Randomised Long-Term Effectiveness Study, Comparing Best Medical Practice With or Without Adjunctive VNS Therapy in Patients 16 Years and Older With Pharmaco-resistant Partial Epilepsy[NCT00522418] | Phase 4 | 122 participants (Actual) | Interventional | 2006-02-28 | Terminated (stopped due to Insufficient enrollment) | ||
| Effect of the Treatment of Vitamin D Deficiency in Drug-resistant Epilepsy[NCT03475225] | Phase 3 | 400 participants (Anticipated) | Interventional | 2018-04-30 | Not yet recruiting | ||
| The Role of Hyaluronic Acid in Reconstruction of Interdental Papilla in The Esthetic Zone[NCT02119741] | 30 participants (Actual) | Observational | 2014-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Post-Traumatic Epilepsy
occurrence of PTE (Post-Traumatic Epilepsy) (NCT01463033)
Timeframe: 2 years
| Intervention | participants (Number) |
|---|---|
| Levetiracetam | 6 |
| Observational | 8 |
Adverse Events
The 66 subjects with acute head injury with a high risk for developing post-traumatic epilepsy that received levetiracetam 55 mg/kg/day in a b.i.d. were monitored for adverse events through the 30 day treatment period. (NCT01463033)
Timeframe: 30 day treatment period
| Intervention | Events (Number) | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Headache | Fatigue | Drowsiness | Memory Impairment | Amnesia | Pain | Irritability | Dizziness | Anorexia | Emotional lability | Insomnia | Cognitive changes | Ataxia | Depression | Hostility | Vertigo | Nausea | Cough | Nervousness | Paraesthesia | Weight gain | Hallucinations | Other | Diplopia | Suicidality | Psychosis | |
| Participants | 28 | 28 | 20 | 9 | 8 | 15 | 10 | 10 | 6 | 7 | 5 | 7 | 6 | 7 | 3 | 1 | 2 | 2 | 5 | 3 | 1 | 5 | 2 | 3 | 3 | 3 |
Change in Number of Absence Seizures From Week 8 (Baseline) to Week 12
The secondary outcome measure is the change in number of absence seizures from Week 8 (Baseline) to Week 12 (NCT01607073)
Timeframe: Week 8 to Week 12
| Intervention | Abscence seizures (Number) |
|---|---|
| Week 8 Baseline | 165 |
| Week 12 Verapamil 4mg/kg/Day | 101 |
Change in Number of General Tonic-clonic Seizures From Week 8 (Baseline) Visit to Week 12 Visit
The primary study endpoint is the change in number of seizures from baseline. Since we only had one participant finish the study, the endpoint was changed to Week 12 visit. Participants were on verapamil for 4 weeks at Week 12. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12
| Intervention | General tonic-clonic seizures (Number) |
|---|---|
| Week 8 Baseline | 39 |
| Week 12 Verapamil 4mg/kg/Day | 14 |
Change in Number of Myoclonic Seizures From Week 8 (Baseline) to Week 12
The secondary outcome is the change in number of myoclonic seizures between baseline Week 8 visit and Week 12 visit. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12
| Intervention | Myoclonic seizures (Number) |
|---|---|
| Week 8 Baseline | 116 |
| Week 12 Verapamil 4mg/kg/Day | 175 |
Change From Baseline in Adverse Event Profile (AEP) Score
Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Mean change from baseline AEP Score at 12 months
| Intervention | Units on a scale (Mean) |
|---|---|
| VNS Therapy | -6.0 |
| Best Medical Practice | -3.2 |
Change From Baseline in Center for Epidemiologic Studies Depression Scale (CES-D) Score
The Center for Epidemiologic Studies Depression Scale (CES-D) includes 20 items comprising six scales reflecting major dimensions of depression: depressed mood, feelings of guilt and worthlessness, feelings of helplessness and hopelessness, psychomotor retardation, loss of appetite, and sleep disturbance. Possible range of scores is 0 to 60, higher scores indicate more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline CES-D Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -2.2 |
| Best Medical Practice | 0.5 |
Change From Baseline in Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) Score
The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is a 6-item questionnaire validated to screen for depression in people with epilepsy. Scores range from 6 to 24, with higher scores indicating more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline NDDI-E Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -1.0 |
| Best Medical Practice | -0.2 |
Changes in Anti-epileptic Drugs (AEDs)
Change from baseline in number of AED medications by visit (NCT00522418)
Timeframe: Change from baseline in number of AEDs at 12 months
| Intervention | Number of AEDs Taken (Median) |
|---|---|
| VNS Therapy | 0 |
| Best Medical Practice | 0 |
Mean Change From Beginning of Intervention Clinical Global Impression-Improvement Scale (CGI-I) Score at 12 Months
The Clinical Global Impression scale (CGI-I) is a 7 point scale that requires the clinician to assess how much the patient's illness has improved or worsened relative to a baseline state at the beginning of the intervention Scores range from 1-7: 1, very much improved; 2, much improved; 3, minimally improved; 4, no change; 5, minimally worse; 6, much worse; or 7, very much worse. (NCT00522418)
Timeframe: Mean change from baseline CGI-I Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -0.8 |
| Best Medical Practice | -0.3 |
Mean Percent Change in Seizure Frequency
Percent change in total seizuires per week from baseline at 12 months (NCT00522418)
Timeframe: Mean percent change from baseline in seizure frequency at 12 months
| Intervention | Percent Change (Mean) |
|---|---|
| VNS Therapy | -19.1 |
| Best Medical Practice | -1.0 |
Overall Quality of Life in Epilepsy-89 (QOLIE-89) Score in Patients With Baseline & at Least One Post-baseline QOLIE Assessment
QOLIE-89 contains 17 multi-item measures of overall quality of life, emotional well-being, role limitations due to emotional problems, social support, social isolation, energy/fatigue, worry about seizure, medication effects, health discouragement, work/driving/social function, attention/concentration, language, memory, physical function, pain, role limitations due to physical problems, and health perceptions. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. (NCT00522418)
Timeframe: Mean change from baseline QOLIE-89 Overall Score at 12 months
| Intervention | units on a scale (Mean) |
|---|---|
| VNS Therapy | 5.5 |
| Best Medical Practice | 1.2 |
Response Rate
Response Rate is defined as the percent of participants who are responders. A Responder is defined as participants with a reduction of at least 50% or 75% in seizure frequency from baseline to the seizure count evaluation period. (NCT00522418)
Timeframe: Number of Responders at 12 Months
| Intervention | participants (Number) |
|---|---|
| VNS Therapy | 10 |
| Best Medical Practice | 7 |
Change From Baseline in QOLIE-89 Measures: Subgroup Analysis of Population With Baseline Adverse Event Profile Score < 40
QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months
| Intervention | units on a scale (Least Squares Mean) | |
|---|---|---|
| VNS Therapy | Best Medical Practice | |
| Baseline Adverse Event Profile Score < 40 | 3.3 | 0.5 |
Change From Baseline in QOLIE-89 Measures: Subgroup Analysis of Population With Baseline Adverse Event Profile Score >= 40
QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months
| Intervention | Units on a Scale (Least Squares Mean) | |
|---|---|---|
| VNS Therapy | Best Medical Practice | |
| Baseline Adverse Event Profile Score >= 40 | 3.3 | 0.7 |
Reviews
219 reviews available for phenytoin and Aura
| Article | Year |
|---|---|
Medicinal chemistry of neuronal voltage-gated sodium channel blockers.
Topics: Amyotrophic Lateral Sclerosis; Analgesics; Anticonvulsants; Epilepsy; Humans; Ion Channel Gating; Mo | 2001 |
The importance of triazole scaffold in the development of anticonvulsant agents.
Topics: Animals; Anticonvulsants; Drug Discovery; Epilepsy; Humans; Triazoles | 2016 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Humans; Network Meta-Analysis; Phenyto | 2022 |
Cutaneous Hypersensitivity Reaction After Phenytoin Therapy in a Neonate: A Case Report and Review of Literature Elucidating the Potential Pharmacological Plausibility and Preventive Strategies.
Topics: Anticonvulsants; Child; Drug Hypersensitivity; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; | 2023 |
Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Lamotrigine; Levetiracetam; Network Meta-Analysis; | 2022 |
The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches.
Topics: Anticonvulsants; Carbamazepine; Dementia; Epilepsy; Felbamate; Gabapentin; Humans; Inflammasomes; La | 2022 |
Pharmacokinetic considerations surrounding the use of levetiracetam for seizure prophylaxis in neurocritical care - an overview.
Topics: Anticonvulsants; Epilepsy; Humans; Levetiracetam; Phenytoin; Piracetam | 2022 |
Breastfeeding while on treatment with antiseizure medications: a systematic review from the ILAE Women Task Force
Topics: Breast Feeding; Cannabidiol; Carbamazepine; Child; Clobazam; Clonazepam; Epilepsy; Ethosuximide; Eve | 2022 |
[Paediatric status epilepticus].
Topics: Adult; Anesthetics; Anticonvulsants; Benzodiazepines; Child; Epilepsy; Humans; Ketamine; Lacosamide; | 2022 |
Challenges in epilepsy diagnosis and management in a low-resource setting: An experience from Bhutan.
Topics: Anticonvulsants; Bhutan; Epilepsy; Humans; Phenytoin; Quality of Life; Social Stigma | 2023 |
Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child.
Topics: Child; Cohort Studies; Epilepsy; Female; Humans; Lamotrigine; Male; Phenytoin; Pregnancy; Prenatal E | 2023 |
Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures.
Topics: Anticonvulsants; Consensus; Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenytoin; Seizures | 2023 |
Anti-seizure medications for neonates with seizures.
Topics: Adolescent; Adult; Child; Epilepsy; Humans; Infant; Infant, Newborn; Levetiracetam; Phenobarbital; P | 2023 |
An update on CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.
Topics: Anticonvulsants; Cytochrome P-450 CYP2C9; Epilepsy; HLA-B Antigens; Humans; Pharmacogenetics; Phenyt | 2020 |
Tics induced by antiepileptic drugs: a pragmatic review.
Topics: Adult; Anticonvulsants; Epilepsy; Humans; Phenytoin; Tic Disorders; Tics | 2021 |
Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications.
Topics: Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam | 2021 |
Cosmetic adverse effects of antiseizure medications; A systematic review.
Topics: Animals; Anticonvulsants; Epilepsy; Humans; Phenytoin; Quality of Life; Valproic Acid | 2021 |
Rational Small Molecule Treatment for Genetic Epilepsies.
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; Genetic Testing; Genetic Therapy; Humans; NAV1. | 2021 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti | 2017 |
Impact of Genetic Polymorphisms on Phenytoin Pharmacokinetics and Clinical Outcomes in the Middle East and North Africa Region.
Topics: Africa, Northern; Anticonvulsants; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Epilepsy; Geno | 2017 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti | 2017 |
Genetic variation in
Topics: Anticonvulsants; Apolipoproteins; Asian People; Carbamazepine; Case-Control Studies; Complement Fact | 2018 |
The association between CYP2C9/2C19 polymorphisms and phenytoin maintenance doses in Asian epileptic patients: A systematic review and meta-analysis
.
Topics: Anticonvulsants; Asian People; Chi-Square Distribution; Cytochrome P-450 CYP2C19; Cytochrome P-450 C | 2018 |
Choice of therapeutic anti-seizure medication in patients with brain tumour.
Topics: Anticonvulsants; Brain Neoplasms; Drug Therapy, Combination; Epilepsy; Gabapentin; Glioma; Humans; L | 2019 |
Effects of phenytoin on serum levels of homocysteine, vitamin B12, folate in patients with epilepsy: A systematic review and meta-analysis (PRISMA-compliant article).
Topics: Anticonvulsants; Epilepsy; Folic Acid; Homocysteine; Humans; Phenytoin; Research Design; Vitamin B 1 | 2019 |
Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review.
Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Humans; Phenytoin; Randomized Controlled Trials as | 2019 |
Seizures and intracranial hemorrhage.
Topics: Anticonvulsants; Carbamazepine; Congenital Abnormalities; Eclampsia; Epilepsy; Female; Folic Acid; H | 2013 |
Oxcarbazepine versus phenytoin monotherapy for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Humans; Induction Chemotherapy; Oxcar | 2013 |
Periodontal growth in areas of vascular malformation in patients with Sturge-Weber syndrome: a management protocol.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Gingiva; Gingival Hyperplasia; Gingivectomy; Humans; Male; | 2014 |
Sulthiame monotherapy for epilepsy.
Topics: Adult; Anticonvulsants; Child; Child, Preschool; Early Termination of Clinical Trials; Epilepsy; Epi | 2014 |
WITHDRAWN: Traditional Chinese medicine for epilepsy.
Topics: Anticonvulsants; Drugs, Chinese Herbal; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medicine, Chinese | 2014 |
HLA-B*1502 increases the risk of phenytoin or lamotrigine induced Stevens-Johnson Syndrome/toxic epidermal necrolysis: evidence from a meta-analysis of nine case-control studies.
Topics: Anticonvulsants; Case-Control Studies; Epilepsy; Genetic Predisposition to Disease; HLA-B15 Antigen; | 2015 |
Burns and epilepsy--review and case report.
Topics: Adult; Anticonvulsants; Burns; Epilepsy; Female; Humans; Phenytoin | 2015 |
CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.
Topics: Anticonvulsants; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Dose-Response Relationship, Drug | 2015 |
Pharmacological treatments for preventing epilepsy following traumatic head injury.
Topics: Adult; Anticonvulsants; Carbamazepine; Cause of Death; Child; Craniocerebral Trauma; Epilepsy; Human | 2015 |
Antiepileptic drugs for seizure control in people with neurocysticercosis.
Topics: Adolescent; Adult; Anticonvulsants; Brain Diseases; Carbamazepine; Child; Child, Preschool; Epilepsy | 2015 |
Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Disease Models, Animal; Electroencephal | 2016 |
Antiepileptic Drugs.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; O | 2016 |
[Preconceptional and perinatal challenges of pregnancy in women with epilepsy].
Topics: Adult; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epileps | 2016 |
Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action.
Topics: Animals; Anticonvulsants; Antineoplastic Agents; Breast Neoplasms; Drug Discovery; Epilepsy; History | 2017 |
Traditional Chinese medicine for epilepsy.
Topics: Anticonvulsants; Drugs, Chinese Herbal; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medicine, Chinese | 2009 |
Arrhythmia, heart rate variability, and antiepileptic drugs.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Elect | 1997 |
New antiepileptic drugs: molecular targets.
Topics: Action Potentials; Animals; Anticonvulsants; Barbiturates; Carbamazepine; Clinical Trials as Topic; | 2009 |
Empact syndrome: a case report and review of the literature.
Topics: Anticonvulsants; Brain Neoplasms; Drug Eruptions; Epilepsy; Humans; Lung Neoplasms; Male; Middle Age | 2010 |
Question 2 Should phenytoin and carbamazepine be avoided in Asian populations with the HLA-B*1502 positive genetic variant?
Topics: Anticonvulsants; Asian People; Carbamazepine; Child; Contraindications; Drug Eruptions; Epilepsy; Ev | 2011 |
Epilepsy (generalised).
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Epilepsy, Generalized; Humans; Incidence; Phenytoin; Remis | 2010 |
Epilepsy (partial).
Topics: Anticonvulsants; Clinical Trials as Topic; Cost-Benefit Analysis; Epilepsies, Partial; Epilepsy; Hum | 2010 |
Epilepsy (partial).
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy; Humans; Phenytoin; Vigabatrin | 2011 |
Pharmacogenetics of the antiepileptic drugs phenytoin and lamotrigine.
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; E | 2011 |
Side effects of phenobarbital in epilepsy: a systematic review.
Topics: Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Cohort Studies; Cross-Over Studies; Data | 2011 |
Management of acute seizure and status epilepticus in pediatric emergency.
Topics: Anesthesia, Intravenous; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Combined Modalit | 2012 |
The effects of antiepileptic drugs on oral health.
Topics: Alveolar Bone Loss; Anticonvulsants; Carbamazepine; Epilepsy; Gingival Hyperplasia; Humans; Oral Hea | 2011 |
Epilepsy (generalised).
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Epilepsy, Generalized; Humans; Incidence; Phenytoin; Remis | 2012 |
Efficacy and safety of innovator versus generic drugs in patients with epilepsy: a systematic review.
Topics: Anticonvulsants; Carbamazepine; Data Interpretation, Statistical; Dose-Response Relationship, Drug; | 2012 |
New antiepileptic drug therapies.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Dioxolanes; Ep | 2002 |
Epilepsy and pregnancy: maternal and fetal effects of phenytoin.
Topics: Adolescent; Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications | 2003 |
[Clinical guidelines for treatment of epilepsy in children].
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Cosyntropin; Electroencephalography; Epileps | 2004 |
Phenobarbital for the treatment of epilepsy in the 21st century: a critical review.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Cost-Benefit Analysis; Developing Countries; Drug Costs; E | 2004 |
Impact of phenytoin therapy on the skin and skin disease.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Child; Connective Tissue Diseases; Drug Eruptio | 2004 |
Cancer risk in people with epilepsy: the role of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Neoplasms; Phenobarbital; Phenytoin; Rats | 2005 |
Therapeutic drug monitoring of old and newer anti-epileptic drugs.
Topics: Anticonvulsants; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Drug Monitoring; Epilepsy; | 2004 |
Pharmacological and clinical aspects of antiepileptic drug use in the elderly.
Topics: Aged; Aging; Anticonvulsants; Epilepsy; Homes for the Aged; Humans; Nursing Homes; Phenytoin; Polyph | 2006 |
Oxcarbazepine versus phenytoin monotherapy for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Humans; Oxcarbazepine; Phenytoin; Ran | 2006 |
[Epilepsy and male sexual dysfunction: etiology, diagnosis and therapy].
Topics: Androgens; Anticonvulsants; Bromocriptine; Carbamazepine; Cognition; Enzyme Induction; Epilepsy; Gon | 2006 |
[Anticonvulsants treatment of psychiatric disorder in elderly patients].
Topics: Aged; Anticonvulsants; Anxiety Disorders; Bipolar Disorder; Carbamazepine; Epilepsy; Humans; Mental | 2006 |
Therapeutic monitoring of antiepileptic drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; Phenobarbital; Phenytoin; Primido | 2007 |
Drug transporters in the epileptic brain.
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain | 2007 |
Treatment of convulsive status epilepticus in infants and young children in Japan.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Child; Child, Preschool; Epilepsy; Humans; Infant; I | 2007 |
Antiepileptic drugs as human teratogens.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital | 2008 |
Clinical pharmacology of parenteral use of antiepileptic drugs.
Topics: Anticonvulsants; Epilepsy; Humans; Infusions, Intravenous; Injections, Intravenous; Levetiracetam; P | 2007 |
Phenytoin: relationship between cerebellar function and epileptic discharges.
Topics: Animals; Cerebellum; Electric Stimulation; Epilepsy; Humans; Neurotransmitter Agents; Phenytoin | 1980 |
Psychopharmacological aspects of antiepileptic treatment.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Electroencephalography; Epilepsy; Ethosux | 1980 |
[Advance and clinic of antiepileptic drugs (author's transl)].
Topics: Animals; Anticonvulsants; Benzodiazepines; Brain; Carbamazepine; Epilepsy; Humans; Ion Channels; Mic | 1981 |
Phenytoin revisited.
Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Cerebrovascular Disorders; Clinical Trials as Topic; | 1984 |
Diagnosis and treatment of epilepsy.
Topics: Automatism; Benzodiazepines; Carbamazepine; Electroencephalography; Epilepsies, Partial; Epilepsy; E | 1983 |
Final adult height of patients with epilepsy.
Topics: Adolescent; Adult; Age Factors; Body Height; Epilepsies, Partial; Epilepsy; Epilepsy, Tonic-Clonic; | 1983 |
Mental effects of antiepileptic medication: a review.
Topics: Adolescent; Adult; Anticonvulsants; Attention; Barbiturates; Brain Chemistry; Carbamazepine; Child; | 1983 |
Clinical pharmacokinetics of sodium valproate, carbamazepine and phenytoin. Level-dose ration and interactions.
Topics: Carbamazepine; Drug Interactions; Epilepsy; Humans; Intestinal Absorption; Kinetics; Phenytoin; Valp | 1984 |
Pharmacological principles in the long-term treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Kinetics; Long | 1981 |
The epileptic mother and her child.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Fetal | 1982 |
Use of antiepileptic drugs in the presence of liver and kidney diseases: a review.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Half-Life; Humans; Kidney Diseases; Kinetics; Liver Diseas | 1982 |
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry.
Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; E | 1980 |
Seizure disorders.
Topics: Animals; Cat Diseases; Cats; Diagnosis, Differential; Diazepam; Dog Diseases; Dogs; Epilepsy; Mephob | 1980 |
Status epilepticus.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Brain; Electroencephalography; Epilepsy; Female; Hum | 1995 |
New anticonvulsant drugs. Focus on flunarizine, fosphenytoin, midazolam and stiripentol.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; Cross-Over Studies; Dioxolanes | 1994 |
Antiepileptic drugs and mechanisms of epileptogenesis. A review.
Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Epilepsy; Phenobarbital; Phenytoin; Receptors, GABA | 1995 |
Phenytoin and carbamazepine: differential effects on cognitive function.
Topics: Carbamazepine; Clinical Trials as Topic; Cognition; Drug Therapy, Combination; Epilepsy; Humans; Neu | 1995 |
Biochemical and molecular teratology of fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Disease Models, Animal; Epilepsy; Face; Female; Fet | 1994 |
Pregnancy, teratogenesis, and epilepsy.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newb | 1994 |
The development of epilepsy in the paediatric brain.
Topics: Age Factors; Animals; Baclofen; Child; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Humans; Infan | 1994 |
Standard approach to antiepileptic drug treatment in the United Kingdom.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Administration Schedule; Drug Monitor | 1994 |
Pharmacologic intervention and treatment of childhood seizure disorders: relative efficacy and safety of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Child; Clinical Trials as Topic; Drug Administration Schedu | 1994 |
[Diagnosis and therapy of epilepsy and myoclonus].
Topics: Acetates; Amines; Cerebral Cortex; Cyclohexanecarboxylic Acids; Electrophysiology; Epilepsy; Gabapen | 1993 |
Drug interaction profile of topiramate.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epile | 1996 |
Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Benzodiazepines; Central Nervous System Disea | 1996 |
Fosphenytoin use in children.
Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Humans; Infant, Newborn; Phenytoin | 1996 |
Intravenous administration of fosphenytoin: options for the management of seizures.
Topics: Anticonvulsants; Epilepsy; Humans; Infusions, Parenteral; Phenytoin; Status Epilepticus | 1996 |
Emergency treatment of status epilepticus.
Topics: Anticonvulsants; Emergencies; Epilepsy; Humans; Phenytoin | 1996 |
Intramuscular use of fosphenytoin: an overview.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Injections, Intramuscular; Male; Phenytoin | 1996 |
Pharmacology and pharmacokinetics of fosphenytoin.
Topics: Animals; Anticonvulsants; Epilepsy; Humans; Phenytoin | 1996 |
Parenteral antiepileptic/anticonvulsant drugs.
Topics: Anticonvulsants; Epilepsy; Humans; Infusions, Parenteral; Phenobarbital; Phenytoin | 1996 |
Antiepileptic drug mechanisms of action.
Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Calciu | 1995 |
Adverse effects of established and new antiepileptic drugs: an attempted comparison.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; gamma-Aminobutyric Acid; Gastrointestinal Disease | 1995 |
Optimisation of antiepileptic drug therapy. The importance of serum drug concentration monitoring.
Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; Phenobarbital; Phenytoin | 1996 |
Safety of fosphenytoin sodium.
Topics: Adult; Anticonvulsants; Biological Availability; Chemistry, Pharmaceutical; Drug Interactions; Epile | 1996 |
Antiepileptic drugs--current use.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenytoin; Valproic Acid | 1996 |
Basis of the antiseizure action of phenytoin.
Topics: Animals; Anticonvulsants; Central Nervous System; Epilepsy; Humans; Neurons; Phenytoin; Sodium Chann | 1996 |
[Antiepileptic drugs: mechanism of action].
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; H | 1996 |
Established antiepileptic drugs.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Epilepsy; Humans; Phenytoin; Succinim | 1996 |
New drug therapy for acute seizure management.
Topics: Acute Disease; Anticonvulsants; Child; Diazepam; Epilepsy; Humans; Phenytoin; Prodrugs; Seizures; Va | 1997 |
Pharmacologic and dietary therapies in epilepsy: conventional treatments and recent advances.
Topics: Acetates; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epil | 1997 |
Recent advancements in epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabap | 1997 |
Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation.
Topics: Anticonvulsants; Area Under Curve; Carbamazepine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-4 | 1997 |
Advances in the medical treatment of epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Diazepam; Drug Approv | 1998 |
Do antiepileptic drugs exacerbate seizures?
Topics: Acute Disease; Anticonvulsants; Epilepsy; Humans; Phenytoin; Seizures | 1998 |
Antiepileptic drug-induced worsening of seizures in children.
Topics: Acute Disease; Anticonvulsants; Child; Drug Overdose; Drug-Related Side Effects and Adverse Reaction | 1998 |
Oral problems and genetic aspects of individuals with epilepsy.
Topics: Dental Care for Chronically Ill; Dental Plaque; Dental Prophylaxis; Epilepsy; Fibroblasts; Gingival | 1994 |
Features and management of poisoning with modern drugs used to treat epilepsy.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenytoin; Valproic Acid | 1998 |
Pediatric use of intravenous and intramuscular phenytoin: lessons learned.
Topics: Anticonvulsants; Chemistry, Pharmaceutical; Child; Child, Preschool; Dose-Response Relationship, Dru | 1998 |
Clinical experience with fosphenytoin in adults: pharmacokinetics, safety, and efficacy.
Topics: Adult; Anticonvulsants; Chemistry, Pharmaceutical; Drug Administration Schedule; Epilepsy; Humans; I | 1998 |
Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs.
Topics: Anticonvulsants; Biotransformation; Carbamazepine; Cytochrome P-450 Enzyme System; Drug Hypersensiti | 1998 |
Antiepileptic drug hypersensitivity syndrome.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross Reactions; Diagnosis, Differential; D | 1998 |
Pharmacokinetics of antiepileptic drugs.
Topics: Adult; Anticonvulsants; Child; Epilepsy; Half-Life; Humans; Kidney; Metabolic Clearance Rate; Phenyt | 1998 |
Phenytoin: effective but insidious therapy for epilepsy in people with intellectual disability.
Topics: Anticonvulsants; Brain; Dose-Response Relationship, Drug; Epilepsy; Humans; Intellectual Disability; | 1998 |
Dilantin jeopardy: avoiding the dangers of phenytoin.
Topics: Adult; Anticonvulsants; Drug Interactions; Drug Monitoring; Epilepsy; Humans; Male; Phenytoin | 1998 |
Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Clinical Trials, Phase II as Topic; Clinical Tria | 1999 |
Monostars: an aid to choosing an antiepileptic drug as monotherapy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Administration S | 1999 |
Oxcarbazepine.
Topics: Adult; Animals; Anticonvulsants; Biological Availability; Biotransformation; Carbamazepine; Controll | 1999 |
Is generic prescribing acceptable in epilepsy?
Topics: Anticonvulsants; Area Under Curve; Biological Availability; Carbamazepine; Chemistry, Pharmaceutical | 2000 |
Reduction of severe gingival overgrowth in a kidney transplant patient by replacing cyclosporin A with tacrolimus.
Topics: Anticonvulsants; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Epilepsy; Female; Gingival | 2000 |
Therapeutic safety monitoring: what to look for and when to look for it.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Monitoring; Epil | 2000 |
New antiepileptic drugs and preparations.
Topics: Acetates; Administration, Rectal; Age Factors; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; | 2000 |
Gender-specific prescribing: medications and the menstrual cycle.
Topics: Adolescent; Adult; Anticonvulsants; Asthma; Bronchodilator Agents; Epilepsy; Female; Humans; Menstru | 1998 |
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic; | 2001 |
Treatment of epilepsy in 3 specialized populations.
Topics: Age Factors; Aged; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Epilepsy; Female; Human | 2001 |
Animal models of drug-resistant epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; | 2002 |
Carbamazepine versus phenytoin monotherapy for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenytoin; Randomized Controlled Trials as Topic | 2002 |
[Diphenylhydantoin. Metabolism, pharmacokinetics, interactions and side effects].
Topics: Anti-Anxiety Agents; Benzodiazepines; Bone and Bones; Bone Marrow; Carbamazepine; Cerebellar Disease | 1976 |
[Pharmacotherapy of epilepsy. II].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Carbamazepin | 1978 |
[Long-term anticonvulsant therapy (author's transl)].
Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Clonazepam; Epilepsy; Ethosuximide; Humans; Long-Te | 1978 |
Valproic acid. Review of a new antiepileptic drug.
Topics: Adolescent; Adult; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Electroencepha | 1979 |
The pharmacological treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies, | 1979 |
Epilepsy and schizophrenia: a neurochemical bridge.
Topics: Amphetamine; Anticonvulsants; Brain; Butyrophenones; Disulfiram; Dopamine; Dopamine beta-Hydroxylase | 1977 |
The medical treatment of epilepsy: initiation of drug therapy.
Topics: Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Bromides; Carbamazepine; Child; Child, Pre | 1979 |
Conceptual issues in the use of drugs for the treatment of aggression in man.
Topics: Adolescent; Adult; Aggression; Alcoholic Intoxication; Animals; Anti-Anxiety Agents; Anticonvulsants | 1975 |
Behavioural effects of anti-epileptic drugs.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Confusion; Disorders of Excess | 1975 |
[Treatment of epileptics with the aid of antiepileptic drug blood level determinations (author's transl)].
Topics: Anticonvulsants; Biological Availability; Dose-Response Relationship, Drug; Drug Interactions; Epile | 1977 |
Pediatric psychopharmacology. A review with special reference to deanol.
Topics: Adolescent; Adult; Amphetamines; Animals; Antidepressive Agents, Tricyclic; Attention Deficit Disord | 1977 |
Brain monoamines in seizure mechanism (review).
Topics: Animals; Brain; Carbonic Anhydrase Inhibitors; Catecholamines; Child; Dextroamphetamine; Dopamine; E | 1977 |
[Epilepsies of infancy and early childhood (author's transl)].
Topics: Clonazepam; Electroencephalography; Epilepsy; Humans; Infant; Infant, Newborn; Infant, Newborn, Dise | 1978 |
[Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)].
Topics: Blood Platelets; Drug Interactions; Electroencephalography; Epilepsy; Fatigue; Half-Life; Humans; Ph | 1978 |
Febrile seizures: the treatment controversy.
Topics: Child; Epilepsy; Humans; Nervous System Diseases; Phenobarbital; Phenytoin; Recurrence; Seizures; Se | 1979 |
Febrile convulsions: diagnosis, treatment, and prognosis.
Topics: Child; Epilepsy; Humans; Infant; Intellectual Disability; Intelligence; Meningitis; Phenobarbital; P | 1979 |
The medical treatment of epilepsy: maintenance of drug therapy.
Topics: Adolescent; Adult; Anticonvulsants; Biological Availability; Bromides; Carbamazepine; Child; Dextroa | 1979 |
The effect of anti-convulsant drugs on cognitive abilities.
Topics: Anticonvulsants; Carbamazepine; Cognition; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; | 1979 |
Pharmacological prophylaxis in the kindling model of epilepsy.
Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carba | 1977 |
Management of seizure disorders: selected aspects. Part I.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Child; Chromatography, Gas; Chromatography, | 1976 |
[Critical remarks on the concept of "osteopathia antiepileptica"].
Topics: Anticonvulsants; Bone Resorption; Calcium; Epilepsy; Humans; Osteomalacia; Phenytoin; Tetany; Vitami | 1976 |
Neurologic disorders in renal failure (first of two parts).
Topics: Blood-Brain Barrier; Brain Diseases; Cerebrospinal Fluid Proteins; Diazepam; Epilepsy; Humans; Lidoc | 1976 |
[Epilepsy and monoamines in the brain].
Topics: Animals; Biogenic Amines; Brain; Catecholamines; Cats; Dihydroxyphenylalanine; Dopamine; Drug Antago | 1975 |
Pharmacological regulation of astrocytic calcium channels: implications for the treatment of seizure disorders.
Topics: Animals; Anticonvulsants; Astrocytes; Calcium; Calcium Channels; Cells, Cultured; Drug Design; Epile | 1992 |
Metabolism of antiepileptic medication: newborn to elderly.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Carbamazepine; Child; Dose-Response Relations | 1992 |
Is there a genetic relationship between epilepsy and birth defects?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Congenital Abnormalities; Dis | 1992 |
Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy.
Topics: Anemia, Aplastic; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Monit | 1991 |
Anticonvulsants: pharmacotherapeutic issues in the critically ill patient.
Topics: Anticonvulsants; Benzodiazepines; Brain Injuries; Carbamazepine; Central Nervous System Diseases; Ep | 1991 |
The newer antiepileptic drugs: carbamazepine and valproic acid.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epilepsy; Humans; Infant | 1991 |
Antiepileptic drugs, cognitive function, and behavior in children: evidence from recent studies.
Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Cognition; Cognition Disorders; Epilepsy; | 1990 |
Immunoglobulins in epilepsy.
Topics: alpha-Fetoproteins; Anticonvulsants; Autoantibodies; Bacterial Infections; DNA; Dysgammaglobulinemia | 1985 |
Medical treatment and pharmacology of antiepileptic drugs.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Epilepsy; Half-Life; Humans; Phenytoin | 1989 |
Efficacy and adverse effects of antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital | 1989 |
Use of phenytoin and carbamazepine in treatment of epilepsy.
Topics: Anemia, Aplastic; Carbamazepine; Cerebellar Ataxia; Chemical and Drug Induced Liver Injury; Cognitio | 1986 |
[GABAergic theory of epilepsy].
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Dogs; E | 1986 |
[Oral loading dose of phenytoin].
Topics: Adult; Aged; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Status Epilepticus | 1988 |
Antiepileptic drugs in adolescents.
Topics: Adaptation, Psychological; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Dru | 1987 |
Mechanisms of anticonvulsant drug action. I. Drugs primarily used for generalized tonic-clonic and partial epilepsies.
Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Humans; Kinetics; Phenobarbital; Phen | 1987 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Humans; Ph | 1987 |
Anticonvulsant drugs and cognitive function: a review of the literature.
Topics: Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Epilepsy; Humans; Phenobarbital; Phe | 1987 |
[Neurotraumatology and post-traumatic epilepsy. Prevention, treatment and long-term follow-up. Barbexaclone + phenobarbital (maliasin) versus diphenylhydantoin, phenobarbital, primidone, carbamazepine].
Topics: Adolescent; Adult; Anticonvulsants; Brain Injuries; Carbamazepine; Child; Child, Preschool; Drug The | 1987 |
[Effect of antiepileptic drugs on thyroid function].
Topics: Epilepsy; Humans; Phenytoin; Thyroid Gland | 1987 |
Current concepts. Seizure disorders and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Administration Schedule; Epilepsy; | 1985 |
Role of the brain-stem reticular formation in tonic-clonic seizures: lesion and pharmacological studies.
Topics: Acoustic Stimulation; Animals; Brain Stem; Electroshock; Epilepsy; Phenytoin; Reticular Formation; S | 1985 |
Pharmacokinetics of anti-epileptic drugs in the dog: a review.
Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Clonazepam; Diazepam; Dog Diseases; Dogs; E | 1985 |
Febrile convulsions. A reappraisal.
Topics: Age Factors; Animals; Animals, Newborn; Body Temperature; Brain; Brain Damage, Chronic; Child, Presc | 1973 |
Anticonvulsants, folic acid, and epilepsy.
Topics: Anemia, Macrocytic; Animals; Anticonvulsants; Blood-Brain Barrier; Chemical Phenomena; Chemistry; Ep | 1973 |
Usefulness of blood levels of antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Chloramphenicol; Chlordiazepoxide; Chlorpromazine; Chromatography, G | 1974 |
Plasma levels of anticonvulsants.
Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Barbiturates; Blood Proteins; Carbamazepine; | 1973 |
Diagnosis and treatment of epilepsy: overview and general principles.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; | 1974 |
[Epilepsy in children].
Topics: Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Absence; Fever; Humans; Infant; | 1974 |
Current drug therapy--antiepilepsy agents.
Topics: Anticonvulsants; Barbiturates; Chemical Phenomena; Chemistry; Drug Interactions; Epilepsies, Partial | 1974 |
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
Effects of tetanization on transmitter dynamics.
Topics: Acetazolamide; Acetylcholine; Action Potentials; Animals; Biological Transport; Carbon Dioxide; Cell | 1969 |
Current trends in Australian neurology.
Topics: Alcoholism; Amino Acids; Aminobutyrates; Animals; Australia; Catecholamines; Central Nervous System; | 1970 |
[Calcium metabolism disorders in antiepileptic therapy].
Topics: Animals; Anticonvulsants; Bone Diseases; Calcium; Calcium Metabolism Disorders; Cholecalciferol; Enz | 1973 |
A basic approach to the understanding of seizures and the mechanism of action and metabolism of anticonvulsants.
Topics: Acetylcholine; Aminobutyrates; Anticonvulsants; Calcium; Cell Membrane Permeability; Depression, Che | 1973 |
Toxic effects of anticonvulsants: general principles.
Topics: Adrenocorticotropic Hormone; Adult; Anticonvulsants; Benzodiazepinones; Body Surface Area; Body Weig | 1974 |
Disordered calcium metabolism during anticonvulsant treatment.
Topics: Adolescent; Animals; Anticonvulsants; Biliary Tract; Bone Diseases; Calcium; Child; Cholecalciferol; | 1973 |
Epilepsy.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Amphetamine; Anesthetics, Local; Anticonvulsants; Ba | 1967 |
The management of children with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Electroencephalography; Epilepsy; Ethosuxim | 1970 |
[The action of hydantoinate in the organism during the therapy of epilepsy with special reference to the origin of gingival hyperplasia. Review II].
Topics: Animals; Culture Techniques; Epilepsy; Gingival Hyperplasia; Humans; Hydantoins; Phenytoin | 1972 |
Epilepsy.
Topics: Animals; Brain; Carbamazepine; Diet Therapy; Epilepsy; Humans; Phenobarbital; Phenytoin | 1972 |
Clinical pharmacology of drug interactions.
Topics: Antihypertensive Agents; Blood Coagulation Disorders; Cardiovascular Diseases; Coumarins; Drug Inter | 1973 |
Recent progress in epilepsy. Diagnostic procedures and treatment.
Topics: Anticonvulsants; Brain Neoplasms; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Temporal Lob | 1973 |
Cerebrospinal folate levels in epileptics and their response to folate therapy.
Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Def | 1974 |
Epilepsy in the adolescent.
Topics: Acetazolamide; Adolescent; Age Factors; Alcoholic Intoxication; Amphetamine; Anticonvulsants; Attitu | 1974 |
The treatment of status epilepticus.
Topics: Anti-Bacterial Agents; Anticonvulsants; Barbiturates; Brain Edema; Central Nervous System Diseases; | 1974 |
The use of blood levels of antiepileptic drugs in clinical practice.
Topics: Administration, Oral; Adult; Anticonvulsants; Biopharmaceutics; Carbamazepine; Child; Drug Tolerance | 1974 |
[Considerations and observations on the pharmacotoxicology of antiepileptic drugs].
Topics: Adolescent; Anticonvulsants; Benzazepines; Epilepsy; Gait; Humans; Libido; Male; Movement Disorders; | 1974 |
Epileptic therapy and gingival considerations.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Disease Models, Animal; Epilepsy; Female; Gingi | 1974 |
Individualization of anticonvulsant therapy.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Body Weight; Dose-Response Relationship, Drug; Drug Int | 1974 |
Convulsions in children.
Topics: Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Ethosuximide; Humans; Infant; M | 1968 |
Neuropharmacology of diphenylhydantoin.
Topics: Animals; Brain; Cell Membrane Permeability; Epilepsy; Feedback; Humans; Learning; Neurons; Phenytoin | 1967 |
Diphenylhydantoin. Its usefulness in clinical disorders of a non-epileptic nature. Discussion on safety.
Topics: Epilepsy; Humans; Mental Disorders; Phenytoin | 1967 |
Anticonvulsant therapy and serum folate.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Depression, Chemical; Epilepsy; Female; | 1969 |
[On the clinical features, histology and etiology of gingival hyperplasia and the hydantoins].
Topics: Diagnosis, Differential; Drug Hypersensitivity; Epilepsy; Gingival Hyperplasia; Humans; Hydantoins; | 1969 |
Role of pharmacological factors in the evaluation of anticonvulsant drugs.
Topics: Acid-Base Equilibrium; Age Factors; Animals; Anticonvulsants; Body Temperature; Cats; Central Nervou | 1969 |
Periodontal disease.
Topics: Adult; Ascorbic Acid Deficiency; Bone Resorption; Child; Dental Deposits; Dental Plaque; Endotoxins; | 1971 |
Osteomalacia and anticonvulsant drugs.
Topics: Alkaline Phosphatase; Anticonvulsants; Calcium; Epilepsy; Folic Acid; Humans; Liver; Osteomalacia; P | 1971 |
[General review of the present therapy of epilepsy].
Topics: Anticonvulsants; Barbiturates; Chlordiazepoxide; Diazepam; Epilepsy; Humans; Hydantoins; Phenobarbit | 1971 |
[Drug therapy of epilepsy].
Topics: Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenobarbital; Phenytoin; Trimethadione; Urea | 1967 |
Trials
191 trials available for phenytoin and Aura
| Article | Year |
|---|---|
AntiEpileptic drug Monitoring in PREgnancy (EMPiRE): a double-blind randomised trial on effectiveness and acceptability of monitoring strategies.
Topics: Anticonvulsants; Carbamazepine; Double-Blind Method; Drug Monitoring; Epilepsy; Female; Humans; Lamo | 2018 |
Effect of switching hepatic enzyme-inducer antiepileptic drug to levetiracetam on bone mineral density, 25 hydroxyvitamin D, and parathyroid hormone in young adult patients with epilepsy.
Topics: Adult; Anticonvulsants; Bone Density; Epilepsy; Female; Femur; Humans; Levetiracetam; Lumbar Vertebr | 2013 |
Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia.
Topics: Acetylcarnitine; Adolescent; Adult; Aged; Aged, 80 and over; Ammonia; Bipolar Disorder; Carnitine; E | 2016 |
Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin.
Topics: Acute Disease; Adult; Aged; Anticonvulsants; Brain; Drug-Related Side Effects and Adverse Reactions; | 2008 |
Anticonvulsant use and outcomes after intracerebral hemorrhage.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Cerebral Hemorrhage; Combined Modality Therapy; Craniotomy | 2009 |
Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new-onset epilepsy: a randomized double-blind clinical trial.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anticonvulsants; Child; Dose-Response Relationship, D | 2010 |
Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new-onset epilepsy: a randomized double-blind clinical trial.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anticonvulsants; Child; Dose-Response Relationship, D | 2010 |
Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new-onset epilepsy: a randomized double-blind clinical trial.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anticonvulsants; Child; Dose-Response Relationship, D | 2010 |
Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new-onset epilepsy: a randomized double-blind clinical trial.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anticonvulsants; Child; Dose-Response Relationship, D | 2010 |
Population pharmacokinetics of carbamazepine in elderly patients.
Topics: Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Body Weight; Carbamazepine; Dose-Response Rel | 2012 |
Results of phase 2 safety and feasibility study of treatment with levetiracetam for prevention of posttraumatic epilepsy.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Brain Injuries; Child; Chr | 2012 |
Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study.
Topics: Adult; Anticonvulsants; Child; Child Development; Child, Preschool; Cognition; Epilepsy; Female; Hum | 2013 |
Randomized evaluation of adverse events and length-of-stay with routine emergency department use of phenytoin or fosphenytoin.
Topics: Adult; Aged; Aged, 80 and over; Drug Administration Schedule; Drug Therapy, Combination; Emergency S | 2002 |
Microdialysis sampling of carbamazepine, phenytoin and phenobarbital in subcutaneous extracellular fluid and subdural cerebrospinal fluid in humans: an in vitro and in vivo study of adsorption to the sampling device.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Extracellular Space; Female; Humans; Male; Microdia | 2002 |
Phenytoin and phenobarbital stable isotope studies in neonates.
Topics: Anticonvulsants; Carbon Isotopes; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Infant; In | 2003 |
Prophylactic phenytoin does not improve cerebral edema or survival in acute liver failure--a controlled clinical trial.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain Edema; Epilepsy; Female; Humans; Liver Failure, Acut | 2004 |
Increased depressant effect of phenytoin sodium as compared to carbamazepine on cortical excitability: a transcranial magnetic evaluation.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Magnetoencephalography; Male; Pheny | 2004 |
Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect.
Topics: Adolescent; Anticonvulsants; Child; Dental Plaque; Epilepsy; Folic Acid; Follow-Up Studies; Gingival | 2004 |
Lack of a clinically significant effect of zonisamide on phenytoin steady-state pharmacokinetics in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Drug Interactions; Epilepsy; Female; Humans; I | 2004 |
Serum albumin-adjusted phenytoin levels: an approach for predicting drug efficacy in patients with epilepsy, suitable for developing countries.
Topics: Adolescent; Adult; Anticonvulsants; Developing Countries; Drug Monitoring; Epilepsy; False Positive | 2004 |
Evaluation of phenytoin dosage regimens based on genotyping of CYP2C subfamily in routinely treated Japanese patients.
Topics: Adolescent; Adult; Anticonvulsants; Asian People; Bayes Theorem; Child; Child, Preschool; Cytochrome | 2005 |
Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy.
Topics: Adolescent; Adult; Age Factors; Aging; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Down | 2005 |
Evaluation of antiepileptic drugs in pregnancy in a Jordanian army hospital.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Clinical Protocols; Drug Monitor | 2005 |
Chronotherapeutic dose schedule of phenytoin and carbamazepine in epileptic patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Chronotherapy; Dose-Response Relationship, | 2006 |
Albendazole therapy for single small enhancing CT lesions (SSECTL) in the brain in epilepsy.
Topics: Adolescent; Adult; Albendazole; Anthelmintics; Carbamazepine; Cerebral Cortex; Child; Child, Prescho | 2008 |
Ineffectiveness of folic acid supplementation against phenytoin-induced decrease in salivary immunoglobulin A concentration of epileptic patients.
Topics: Dietary Supplements; Epilepsy; Female; Folic Acid; Humans; IgA Deficiency; Male; Middle Aged; Phenyt | 2008 |
Postoperative epilepsy: a double-blind trial of phenytoin after craniotomy.
Topics: Clinical Trials as Topic; Craniotomy; Double-Blind Method; Epilepsy; Humans; Phenytoin; Postoperativ | 1980 |
Serum concentrations and enzyme induction in epileptic children treated with phenytoin and valproate.
Topics: Child; Enzyme Induction; Epilepsy; gamma-Glutamyltransferase; Humans; Phenytoin; Valproic Acid | 1982 |
Historical perspective on the choice of antiepileptic drugs for the treatment of seizures in adults.
Topics: Adult; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Epilepsy; History, 20th Century; Hu | 1983 |
Phenytoin and postoperative epilepsy. A double-blind study.
Topics: Clinical Trials as Topic; Craniotomy; Double-Blind Method; Epilepsy; Female; Humans; Male; Middle Ag | 1983 |
Phenytoin revisited.
Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Cerebrovascular Disorders; Clinical Trials as Topic; | 1984 |
[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and child development].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Akathisia, Drug-Induced; Anencephaly; Ant | 1983 |
Controlled and comparative trials of valproate performed in Europe and Asia.
Topics: Adolescent; Adult; Asia; Carbamazepine; Child; Clinical Trials as Topic; Epilepsy; Europe; Humans; P | 1984 |
Controlled and comparative trials with valproate: United States.
Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Epilepsy; Epilepsy, Absence; E | 1984 |
A randomised trial of strategies to improve patient compliance with anticonvulsant therapy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Counseling; Drug Packag | 1984 |
Influence of therapeutic phenobarbital and phenytoin medication on the polygraphic sleep of patients with epilepsy.
Topics: Adolescent; Adult; Aged; Drug Interactions; Epilepsies, Partial; Epilepsy; Female; Humans; Male; Mid | 1984 |
Role of combination of valproic acid with diphenylhydantoin and carbamazepine in the management of intractable seizures.
Topics: Adolescent; Adult; Carbamazepine; Clinical Trials as Topic; Drug Therapy, Combination; Epilepsy; Fem | 1984 |
Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy.
Topics: Adolescent; Adult; Aged; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Pregnancy; T | 1981 |
A comparison of phenytoin and valproate in previously untreated adult epileptic patients.
Topics: Adolescent; Adult; Age Factors; Aged; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Humans | 1982 |
A comparison of phenytoin and pheneturide in patients with epilepsy: a double-blind cross-over trial.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Clinical Trials as Topic; Double-Blind Method; Epilepsies, | 1982 |
Influence of dextropropoxyphene on steady state serum levels and protein binding of three anti-epileptic drugs in man.
Topics: Adolescent; Adult; Aged; Carbamazepine; Chromatography, Gas; Chromatography, High Pressure Liquid; C | 1980 |
The influence of folic acid on the frequency of epileptic attacks.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Epilepsy; Female; Folic Acid; Humans; Male; Ph | 1981 |
Kinetics of phenobarbital in normal subjects and epileptic patients.
Topics: Administration, Oral; Adult; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Injec | 1982 |
Phenytoin and cognitive function: effects on normal volunteers and implications for epilepsy.
Topics: Adolescent; Adult; Attention; Cognition; Decision Making; Epilepsy; Humans; Male; Memory; Motor Skil | 1981 |
Comparing the cognitive effects of phenytoin and carbamazepine in long-term monotherapy: a two-year follow-up.
Topics: Adult; Affect; Carbamazepine; Cognition; Epilepsy; Female; Follow-Up Studies; Humans; Male; Neuropsy | 1995 |
New anticonvulsant drugs. Focus on flunarizine, fosphenytoin, midazolam and stiripentol.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; Cross-Over Studies; Dioxolanes | 1994 |
Thyroid status of patients receiving long-term anticonvulsant therapy assessed by peripheral parameters: a placebo-controlled thyroxine therapy trial.
Topics: Adult; Age Distribution; Anticonvulsants; Carbamazepine; Comorbidity; Cross-Over Studies; Double-Bli | 1995 |
Systematic approach to a dosage regimen for phenytoin based on one-point, steady-state plasma concentration.
Topics: Adult; Bayes Theorem; Epilepsy; Female; Humans; Male; Phenytoin; Retrospective Studies | 1995 |
[Effects of phenytoin and cabamazepine on sex hormones in male patients with epilepsy: a controlled study].
Topics: Adolescent; Adult; Carbamazepine; Case-Control Studies; Epilepsy; Estradiol; Humans; Male; Phenytoin | 1994 |
Cognitive side-effects of phenytoin compared with carbamazepine in patients with localization-related epilepsy.
Topics: Adolescent; Adult; Attention; Carbamazepine; Cognition Disorders; Epilepsy; Female; Humans; Male; Me | 1994 |
Clinical rules for phenytoin dosing.
Topics: Adult; Computer Simulation; Drug Therapy, Computer-Assisted; Epilepsy; Female; Humans; Male; Middle | 1993 |
Renal tubular dysfunction following treatment with anti-epileptic drugs.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross-Sectional Studies; Epilep | 1994 |
Flunarizine for treatment of partial seizures: results of a concentration-controlled trial.
Topics: Adolescent; Adult; Aged; Carbamazepine; Dose-Response Relationship, Drug; Double-Blind Method; Drug | 1994 |
[Clinical analysis of 72 epileptic patients treated with alkaline extract of Euphorbia fisheriana].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Drugs, Chinese | 1994 |
Pharmacokinetics of phenytoin in routine clinic patients in Malaysia.
Topics: Adolescent; Adult; Asian People; Body Weight; Child; Epilepsy; Female; Humans; Linear Models; Malays | 1994 |
Dosage adjustments in response to monitored plasma concentrations: can unblinded staff adhere to objective criteria?
Topics: Attitude of Health Personnel; Carbamazepine; Dose-Response Relationship, Drug; Double-Blind Method; | 1994 |
A double-blind, placebo-controlled interaction study between oxcarbazepine and carbamazepine, sodium valproate and phenytoin in epileptic patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Double-Blind Method; Drug Interactions; Epilepsy; Female; Hal | 1994 |
Effects of phenytoin and carbamazepine on cognitive functions in newly diagnosed epileptic patients.
Topics: Adult; Carbamazepine; Cognition Disorders; Epilepsy; Female; Follow-Up Studies; Humans; Learning; Ma | 1994 |
Carbamazepine and phenytoin in epilepsies refractory to barbiturates: efficacy, toxicity and mental function.
Topics: Adolescent; Adult; Affect; Carbamazepine; Child; Cognition; Epilepsies, Partial; Epilepsy; Female; H | 1993 |
Thiamine and folate treatment of chronic epileptic patients: a controlled study with the Wechsler IQ scale.
Topics: Adult; Brain; Double-Blind Method; Drug Therapy, Combination; Education; Electroencephalography; Epi | 1993 |
Developmental and therapeutic pharmacology of antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Dru | 1993 |
Comparison of the effectiveness of two oral phenytoin products and chronopharmacokinetics of phenytoin.
Topics: Administration, Oral; Adult; Biological Availability; Circadian Rhythm; Drug Administration Schedule | 1993 |
Withdrawal of antiepileptic medication in children--effects on cognitive function: The Multicenter Holmfrid Study.
Topics: Adolescent; Carbamazepine; Child; Cognition; Cognition Disorders; Epilepsy; Female; Follow-Up Studie | 1993 |
Psychiatric aspects of epilepsy in childhood treated with carbamazepine, phenytoin or sodium valproate: a random trial.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Humans; Mal | 1993 |
Effect of felbamate on carbamazepine and its major metabolites.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Double-Blind Method; Drug Interactions; Epilepsy; | 1993 |
Phenytoin as a risk factor in gingival hyperplasia.
Topics: Adult; Analysis of Variance; Anticonvulsants; Chi-Square Distribution; Drug Therapy, Combination; Ep | 1995 |
A comparison of the OPUS and TDx analysers for antiepileptic drug monitoring.
Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Female; Fluorescence Polarization Immunoa | 1995 |
Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; | 1996 |
Assessment of drowsiness in epilepsy patients receiving chronic antiepileptic drug therapy.
Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy; Humans; Middle | 1996 |
Systematic testing of medical intractability for carbamazepine, phenytoin, and phenobarbital or primidone in monotherapy for patients considered for epilepsy surgery.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clinical Protocols; Dose | 1996 |
Safety and tolerance of multiple doses of intramuscular fosphenytoin substituted for oral phenytoin in epilepsy or neurosurgery.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Drug Tolerance; Epilepsy; Female; Humans; Male; Middle Age | 1996 |
Effect of enzyme inducing anticonvulsants on ethosuximide pharmacokinetics in epileptic patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Enzyme Induction; Epilepsy; Ethosuximide; | 1996 |
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System | 1996 |
Brainstem auditory evoked potentials in epileptics on different anti-epileptic drugs.
Topics: Acoustic Stimulation; Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Combinations; Epilepsy | 1996 |
Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication.
Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; D | 1996 |
Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: analysis with a dose-dependent clearance model.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Biological Availability; Child; Child, Preschool; D | 1996 |
Findings in children exposed in utero to phenytoin and carbamazepine monotherapy: independent effects of epilepsy and medications.
Topics: Adult; Carbamazepine; Cohort Studies; Craniofacial Abnormalities; Epilepsy; Female; Fingers; Humans; | 1997 |
Phenytoin kinetics in Japanese adult epileptics: phenotype of phenytoin slow metabolizers.
Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Japa | 1997 |
Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Bayes Theorem; Child; Child, Pres | 1997 |
Homocyst(e)ine levels in patients on phenytoin therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Epilepsy; Female; Homocysteine; Humans; | 1997 |
Cognitive effects of anticonvulsant monotherapy in elderly patients: a placebo-controlled study.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Cognition Disorders; Dose-Response Relation | 1998 |
Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy.
Topics: Adolescent; Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; C | 1998 |
Antiepileptic drug therapy and sexual function in men with epilepsy.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Androgen-Binding Protein; Androstenedione; Anticonvul | 1999 |
[Treatment for generalized seizures: the best of four methods].
Topics: Anticonvulsants; Diazepam; Epilepsy; Humans; Lorazepam; Phenobarbital; Phenytoin | 1999 |
Anti-epileptic drug intake adherence. The value of the blood drug level measurement and the clinical approach.
Topics: Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Drug Monitoring; Epilepsy; Female; Humans; | 1998 |
Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Combinations; Epilepsy; Female; Human | 1999 |
Spotlight on the continual applicability of routine plasma monitoring antiepileptic drugs in the treatment of epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Monitoring; Drug Therapy, Combination; Epile | 1999 |
Genotoxicity of the anticonvulsant drug phenytoin (PHT): a follow-up study of PHT-untreated epileptic patients. I. Sister chromatid exchange (SCE) analysis.
Topics: Adolescent; Adult; Age Factors; Age of Onset; Anticonvulsants; Child; Epilepsy; Female; Humans; Male | 1999 |
Fracture risk is increased in epilepsy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Biomechanical Phenomena; Epilepsy; Fema | 1999 |
Lamotrigine monotherapy in newly diagnosed untreated epilepsy: a double-blind comparison with phenytoin.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Double-Blind Method; Drug Administration Schedule; Epileps | 1999 |
Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study.
Topics: Acetates; Adolescent; Adult; Ambulatory Care; Amines; Anticonvulsants; Asthenia; Carbamazepine; Cycl | 1999 |
A case control study and one year follow-up of registered epilepsy cases in a resettlement colony of North India, a developing tropical country.
Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Child; Craniocerebral Trauma; Developmenta | 1999 |
Coadministration of phenytoin and felbamate: evidence of additional phenytoin dose-reduction requirements based on pharmacokinetics and tolerability with increasing doses of felbamate.
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interac | 1999 |
Comparative double blind clinical trial of phenytoin and sodium valproate as anticonvulsant prophylaxis after craniotomy: efficacy, tolerability, and cognitive effects.
Topics: Adult; Aged; Brain Diseases; Cognition; Craniotomy; Double-Blind Method; Epilepsy; Female; Humans; M | 1999 |
Age-related alteration of carbamazepine-serum protein binding in man.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anticonvulsants; Child; Child, Preschool; Diethyl | 1999 |
Optimization of phenytoin therapy in adults with epilepsy in the Western Cape, South Africa.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Dose-Response Relationship, Drug; Epile | 1999 |
Lack of pharmacokinetic interaction between grapefruit juice and phenytoin in healthy male volunteers and epileptic patients.
Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Fruit; Humans; Male; Middle Aged; Phenytoin; Se | 1999 |
Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus.
Topics: Alleles; Amino Acid Substitution; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome | 2000 |
Total percentage body weight changes during add-on therapy with tiagabine, carbamazepine and phenytoin.
Topics: Anticonvulsants; Body Weight; Carbamazepine; Double-Blind Method; Drug Therapy, Combination; Epileps | 2000 |
Topiramate in refractory epilepsy: a prospective observational study.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Anticonvulsants; Carbamazepine; Drug Administration Schedu | 2000 |
Influence of vitamin D administration on bone ultrasound measurements in patients on anticonvulsant therapy.
Topics: 25-Hydroxyvitamin D 2; Adult; Aged; Anticonvulsants; Bone and Bones; Calcifediol; Carbamazepine; Epi | 2000 |
Fosphenytoin: pharmacokinetics and tolerance of intramuscular loading doses.
Topics: Adolescent; Anticonvulsants; Child; Dose-Response Relationship, Drug; Double-Blind Method; Drug Admi | 2001 |
Effect of temperature on binding characteristics of phenytoin to serum proteins in monotherapy adult patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Blood Proteins; Epilepsy; Female; Humans; Male; Middle Aged; Phe | 2000 |
A prospective study of the incidence of the purple glove syndrome.
Topics: Aged; Anticonvulsants; Edema; Epilepsy; Female; Forearm; Hand; Humans; Incidence; Infusions, Intrave | 2001 |
Prospective study of local cutaneous reactions in patients receiving IV phenytoin.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Contusions; Edema; Epilepsy; Female; Humans; Incide | 2001 |
Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 800 mg/day) in a B.I.D. regimen.
Topics: Acetamides; Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Confid | 2002 |
Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 1200 mg/day) in a Q.I.D. regimen.
Topics: Acetamides; Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Dose-R | 2002 |
[Evaluation of antiepileptic therapy during pregnancy].
Topics: Adult; Anticonvulsants; Apgar Score; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenobarbi | 2002 |
Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Dr | 2002 |
Seizure reduction and quality of life improvements in people with epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Attitude to Health; Carbamazepine; Drug Therapy, Combinati | 2002 |
Letter: Bioavailability of phenytoin.
Topics: Adolescent; Adult; Biological Availability; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin | 1976 |
Letter: Serum-phenytoin.
Topics: Adult; Biological Availability; Child; Epilepsy; Humans; Male; Phenytoin; Time Factors | 1976 |
One drug (phenytoin) in the treatment of epilepsy.
Topics: Adolescent; Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Epilepsy; Epilepsy, Absence; Ep | 1976 |
Carbamazepine vs phenytoin. A controlled clinical trial in focal motor and generalized epilepsy.
Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epilepsies, P | 1979 |
Loading and conventional dose therapy with phenytoin in children: kinetic profile of parent drug and main metabolite in plasma.
Topics: Adolescent; Child; Child, Preschool; Clinical Trials as Topic; Drug Administration Schedule; Drug Er | 1976 |
[Value of anticonvulsant level determination in the treatment of epilepsies].
Topics: Clinical Trials as Topic; Drug Administration Schedule; Epilepsy; Humans; Patient Dropouts; Phenobar | 1977 |
[Experiences with sodium 2-propyl valerate (Depakine) in the treatment of epilepsy].
Topics: Adolescent; Adult; Aged; Carbamazepine; Cerebrospinal Fluid Shunts; Child; Child, Preschool; Clinica | 1977 |
Long-term use of phenytoin: effects on bone-marrow chromosomes in man.
Topics: Adolescent; Adult; Bone Marrow; Bone Marrow Cells; Child; Child, Preschool; Chromosome Aberrations; | 1977 |
Valproate sodium: a controlled clinical trial including monitoring of drug levels.
Topics: Adult; Child; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Drug Therapy, Combinat | 1977 |
Psychotropic effects of carbamazepine in epilepsy: a double-blind comparison with phenytoin.
Topics: Adult; Attention; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Emo | 1977 |
Oral use of chlorhexidine gluconate toothpaste in epileptic children.
Topics: Administration, Oral; Adolescent; Biguanides; Child; Child, Preschool; Chlorhexidine; Clinical Trial | 1978 |
Valproic acid in epilepsy: clinical and pharmacological effects.
Topics: Adult; Binding, Competitive; Biological Availability; Blood Proteins; Clinical Trials as Topic; Drug | 1978 |
Clonazepam: its efficacy in association with phenytoin and phenobarbital in mental patients with generalized major motor seizures.
Topics: Benzodiazepinones; Clinical Trials as Topic; Clonazepam; Double-Blind Method; Drug Therapy, Combinat | 1978 |
Carbamazepine and the electroencephalogram of epileptics: a double blind study in comparison to phenytoin.
Topics: Adult; Carbamazepine; Clinical Trials as Topic; Electroencephalography; Epilepsy; Humans; Hyperventi | 1978 |
Sodium valproate, serum level and clinical effect in epilepsy: a controlled study.
Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Dimethadione; Dose-Response Relati | 1979 |
Fractional intestinal calcium absorption in epileptics on anticonvulsant therapy. Short-term effect of 1,25-dihydroxycholecalciferol and 25-hydroxycholecalciferol.
Topics: Administration, Oral; Adult; Alkaline Phosphatase; Anticonvulsants; Calcium; Dihydroxycholecalcifero | 1979 |
The therapeutic range for phenytoin--a reappraisal.
Topics: Adolescent; Adult; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Prospective Studie | 1979 |
One drug for epilepsy.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoi | 1978 |
Phenytoin dosage in ambulant epileptic patients.
Topics: Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phenytoin | 1978 |
Oral and intramuscular phenytoin.
Topics: Administration, Oral; Adult; Clinical Trials as Topic; Drug Administration Schedule; Epilepsy; Epile | 1976 |
Control of epilepsy with a single daily dose of phenytoin sodium.
Topics: Adolescent; Adult; Clinical Trials as Topic; Epilepsy; Female; Humans; Male; Phenytoin | 1975 |
[Changes in serum concentrations of calcium and inorganic phosphates and alkaline phosphatase activity due to anti-ipileptic treatment].
Topics: Adolescent; Adult; Alkaline Phosphatase; Calcium; Clinical Trials as Topic; Epilepsy; Female; Humans | 1976 |
Carbamazepine (Tegretol) as an anticonvulsant. A controlled double-blind comparison with diphenylhydantoin (Dilantin).
Topics: Adult; Carbamazepine; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Epile | 1975 |
Controlled trial of sodium valproate in severe epilepsy.
Topics: Adult; Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Epilepsy; Female; Humans; Male; | 1975 |
The efficacy of carbamazepine combinations in epilepsy.
Topics: Adult; Biological Availability; Carbamazepine; Clinical Trials as Topic; Drug Administration Schedul | 1975 |
Anticonvulsants in the treatment of aggression.
Topics: Adult; Aggression; Anticonvulsants; Chlordiazepoxide; Chlorpromazine; Drug Therapy, Combination; Epi | 1975 |
Cognitive effects of oxcarbazepine and phenytoin monotherapy in newly diagnosed epilepsy: one year follow-up.
Topics: Adult; Anticonvulsants; Attention; Carbamazepine; Cognition; Double-Blind Method; Epilepsy; Female; | 1992 |
Do prophylactic anticonvulsant drugs alter the pattern of seizures after craniotomy?
Topics: Actuarial Analysis; Adolescent; Adult; Aged; Brain Diseases; Carbamazepine; Craniotomy; Dose-Respons | 1992 |
Effects of withdrawal of phenytoin on cognitive and psychomotor functions in hospitalized epileptic patients on polytherapy.
Topics: Adult; Anticonvulsants; Attention; Cognition; Dose-Response Relationship, Drug; Drug Therapy, Combin | 1992 |
Bioavailability and dissolution of proprietary and generic formulations of phenytoin.
Topics: Adolescent; Adult; Biological Availability; Dose-Response Relationship, Drug; Drug Administration Sc | 1992 |
Clinical trial on sustained-release phenytoin. Preliminary results of the open, non-controlled study. The Phenytoin Trial Group on Canine Epilepsy.
Topics: Animals; Delayed-Action Preparations; Dog Diseases; Dogs; Epilepsy; Phenytoin | 1992 |
The administration of folic acid to institutionalized epileptic adults with phenytoin-induced gingival hyperplasia. A double-blind, randomized, placebo-controlled, parallel study.
Topics: Adult; Dental Care for Disabled; Dental Plaque Index; Double-Blind Method; Epilepsy; Female; Folic A | 1991 |
Cognitive impairment in new cases of epilepsy randomly assigned to carbamazepine, phenytoin and sodium valproate.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cognition; Epilepsy; Humans; In | 1991 |
Discontinuation of antiepileptic drugs in children who have outgrown epilepsy: effects on cognitive function.
Topics: Adolescent; Anticonvulsants; Attention; Carbamazepine; Child; Cognition; Epilepsy; Ethosuximide; Hum | 1990 |
[Clinical and experimental control of optimal therapy in epilepsy].
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Neurocognitive Disorder | 1990 |
Comparative cognitive effects of anticonvulsants.
Topics: Adult; Anticonvulsants; Carbamazepine; Cognition; Epilepsy; Female; Humans; Male; Middle Aged; Neuro | 1990 |
A comparative bioavailability of 2 oral solid phenytoin dosage forms.
Topics: Administration, Oral; Adult; Biological Availability; Epilepsy; Female; Humans; Male; Phenytoin; Ran | 1989 |
A multicentre study of vigabatrin for drug-resistant epilepsy.
Topics: Adult; Aged; Aminocaproates; Anticonvulsants; Clinical Trials as Topic; Drug Resistance; Epilepsy; F | 1989 |
Phenytoin prodrug: preclinical and clinical studies.
Topics: Adult; Aged; Clinical Trials as Topic; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Place | 1989 |
Folate treatment of diphenylhydantoin-induced gingival hyperplasia.
Topics: Adolescent; Child; Epilepsy; Female; Folic Acid; Gingival Hyperplasia; Humans; Intellectual Disabili | 1989 |
Compliant populations: variability in serum concentrations.
Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combina | 1988 |
Serum levels of sodium valproate, phenytoin and carbamazepine and seizure control in epilepsy.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Fema | 1986 |
A comparative study of progabide, valproate, and placebo as add-on therapy in patients with refractory epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug | 1986 |
Withdrawal of anticonvulsant drugs in patients free of seizures for two years. A prospective study.
Topics: Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies, Par | 1988 |
Withdrawal symptoms from phenytoin, carbamazepine and sodium valproate.
Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, | 1988 |
Aspects of compliance: taking drugs and keeping clinic appointments.
Topics: Adolescent; Adult; Anticonvulsants; Appointments and Schedules; Carbamazepine; Clinical Trials as To | 1988 |
Results of a nationwide Veterans Administration Cooperative Study comparing the efficacy and toxicity of carbamazepine, phenobarbital, phenytoin, and primidone.
Topics: Adult; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epilepsy; Humans; Phenobarbital | 1987 |
Progabide for refractory partial epilepsy: a controlled add-on trial.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Double-Blind Meth | 1986 |
Single-dose oral phenytoin loading.
Topics: Administration, Oral; Adult; Aged; Capsules; Drug Administration Schedule; Epilepsy; Female; Humans; | 1987 |
Which drug for the adult epileptic patient: phenytoin or valproate?
Topics: Adolescent; Adult; Aged; Body Weight; Clinical Trials as Topic; Epilepsies, Partial; Epilepsy; Femal | 1985 |
Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures.
Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epilepsies, P | 1985 |
[Efficient serum concentrations after single doses of antiepileptic drugs: concept of loading-dose].
Topics: Absorption; Administration, Oral; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epil | 1985 |
Influence of folic acid on blood-phenytoin levels.
Topics: Adult; Anticonvulsants; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Male; Phenobarbital; Ph | 1971 |
Electroencephalographic investigations during evaluation of the antiepileptic agent sulthiame.
Topics: Anticonvulsants; Clinical Trials as Topic; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe | 1974 |
Sulthiame: evaluation as an anticonvulsant.
Topics: Anticonvulsants; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Evaluation; Electr | 1974 |
Relation of abnormal folate metabolism to neuropathy developing during anticonvulsant drug therapy.
Topics: Adolescent; Adult; Anticonvulsants; Biological Assay; Child; Electrodiagnosis; Electromyography; Epi | 1968 |
Evaluation of albutoin as an antiepileptic drug.
Topics: Adolescent; Adult; Allyl Compounds; Analysis of Variance; Anticonvulsants; Appetite; Biopharmaceutic | 1974 |
"Anticonvulsant action" of vitamin D in epileptic patients? A controlled pilot study.
Topics: Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Calcium; Child; Clinical Trials as Topic; | 1974 |
Carbamazepine for epilepsy. A controlled prospective evaluation.
Topics: Adult; Blood Cell Count; Bone Marrow Diseases; Carbamazepine; Clinical Trials as Topic; Electroencep | 1974 |
Gingival hyperplasia related to treatment with diphenylhydantoin (diphedan; DH).
Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Child; Child, Presc | 1969 |
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
Drug--interaction between sulthiame (Ospolot (R)) and phenytoin in the treatment of epilepsy.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Thiazines; Time Fa | 1969 |
Blood phenytoin concentrations produced by ingestion of three different phenytoin preparations.
Topics: Adolescent; Adult; Calcium; Clinical Trials as Topic; Drug Compounding; Epilepsy; Epilepsy, Temporal | 1972 |
Effect of chronic anticonvulsant therapy on serum 25-hydroxycalciferol levels in adults.
Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Calcium; Clinical Trials as Topic; Epilepsy; Ergocalci | 1972 |
Effect of vitamin D on bone mineral mass in normal subjects and in epileptic patients on anticonvulsants: a controlled therapeutic trial.
Topics: Absorption; Adult; Bone and Bones; Calcium; Clinical Trials as Topic; Epilepsy; Female; Humans; Ligh | 1973 |
Folate therapy in epilepsy. A controlled study.
Topics: Clinical Trials as Topic; Cognition; Epilepsy; Evaluation Studies as Topic; Folic Acid; Humans; Leuc | 1973 |
[Short report on the effect of the anticonvulsant Ro 5-4023 (clonazepam) in different forms of epilepsy].
Topics: Adolescent; Anticonvulsants; Barbiturates; Benzodiazepinones; Carbamazepine; Child; Child, Preschool | 1973 |
Cerebrospinal folate levels in epileptics and their response to folate therapy.
Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Def | 1974 |
Clonazepam--a clinical study of its effectiveness as an anticonvulsant.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepinones; Child; Child, Preschool; Chlorobenzenes; Clin | 1973 |
Renal insensitivity to frusemide caused by chronic anticonvulsant therapy.
Topics: Administration, Oral; Adult; Anticonvulsants; Clinical Trials as Topic; Diuresis; Drug Interactions; | 1974 |
Effect of vitamin D2 on serum phenytoin. A controlled therapeutical trial.
Topics: Adult; Aged; Clinical Trials as Topic; Drug Interactions; Epilepsy; Ergocalciferols; Female; Humans; | 1974 |
Incidence of anticonvulsant osteomalacia and effect of vitamin D: controlled therapeutic trial.
Topics: Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Bone and Bones; Calcium; Creatinine; Epilepsy; F | 1973 |
Behavioral effects of diphenylhydantoin in severe psychiatric disorders.
Topics: Adolescent; Adult; Character; Child; Clinical Trials as Topic; Electroencephalography; Epilepsy; Fem | 1967 |
The psychoactive properties of diphenylhydantoin: experiences with prisoners and juvenile delinquents.
Topics: Adolescent; Adult; Affect; Child; Child Behavior Disorders; Clinical Trials as Topic; Criminal Psych | 1967 |
Subnormal serum folate due to anticonvulsive therapy. A double-blind study of the effect of folic acid treatment in patients with drug-induced subnormal serum folates.
Topics: Adult; Anticonvulsants; Clinical Trials as Topic; Epilepsy; Erythrocyte Count; Female; Folic Acid; H | 1970 |
[Clinical pharmacology (13): therapy control. Discussion introduction].
Topics: Clinical Trials as Topic; Drug Therapy; Epilepsy; Humans; Phenytoin; Thyroxine | 1970 |
Evaluation of folic acid supplements in children taking phenytoin.
Topics: Adolescent; Child; Child Behavior Disorders; Clinical Trials as Topic; Electroencephalography; Epile | 1971 |
A survey of 156 seizure patients in a general pediatric clinic.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Epilepsy; Epilepsy, | 1966 |
Acute treatment of epileptic seizures with diazepamum (Valium).
Topics: Acute Disease; Adolescent; Adult; Aged; Aphasia; Clinical Trials as Topic; Diazepam; Epilepsy; Epile | 1967 |
Diphenylhydantoin as an anticonvulsant: evaluation of treatment in forty mentally subnormal epileptics.
Topics: Adolescent; Adult; Chlorpromazine; Clinical Trials as Topic; Electroencephalography; Epilepsies, Par | 1969 |
Relative anticonvulsant potency of primidone; a double blind comparison.
Topics: Clinical Trials as Topic; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Primidone | 1966 |
Studies on the metabolism of phenytoin.
Topics: Clinical Trials as Topic; Electroencephalography; Epilepsy; Humans; Phenytoin | 1966 |
Phenytoin intoxication during treatment with antabuse (Disulfiram).
Topics: Adult; Alcoholism; Clinical Trials as Topic; Disulfiram; Drug Compounding; Drug Incompatibility; Epi | 1966 |
The influence of phenobarbital on the half-life of diphenylhydantoin in man.
Topics: Adolescent; Adult; Aged; Carbon Isotopes; Enzyme Induction; Epilepsy; Humans; Metabolic Clearance Ra | 1969 |
Other Studies
2159 other studies available for phenytoin and Aura
| Article | Year |
|---|---|
Functionalized DL-amino acid derivatives. Potent new agents for the treatment of epilepsy.
Topics: Amino Acids; Animals; Anticonvulsants; Epilepsy; Magnetic Resonance Spectroscopy; Male; Mice; Seizur | 1987 |
Structure-activity relationships of phenytoin-like anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Electroshock; Epilepsy; Magnetic Resonance S | 1984 |
Synthesis and evaluation of N-(phenylacetyl)trifluoromethanesulfonamides as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Body Weight; Cytochrome P-450 Enzyme System; Epilepsy; Mesylates; Mice; NA | 1996 |
Newer GABA derivatives for the treatment of epilepsy including febrile seizures: a bioisosteric approach.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Dru | 2008 |
Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives.
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Drug Synergism; Epilepsy; Liver; Mice; Nervo | 2010 |
Combating oxidative stress in epilepsy: design, synthesis, quantum chemical studies and anticonvulsant evaluation of 1-(substituted benzylidene/ethylidene)-4-(naphthalen-1-yl)semicarbazides.
Topics: Animals; Anticonvulsants; Antioxidants; Benzylidene Compounds; Drug Design; Electrons; Epilepsy; Mal | 2010 |
Synthesis and anticonvulsant activity of new 6-methyl-1-substituted-4,6-diazaspiro[2.4]heptane-5,7-diones.
Topics: Animals; Anticonvulsants; Electroshock; Epilepsy; Heptanes; Male; Mice; Pentylenetetrazole; Structur | 2010 |
Synthesis and anticonvulsant activity of novel 2,6-diketopiperazine derivatives. Part 1: perhydropyrrole[1,2-a]pyrazines.
Topics: Animals; Anticonvulsants; Diketopiperazines; Electroshock; Epilepsy; Humans; Male; Mice; Models, Mol | 2011 |
Design, synthesis and antiepileptic properties of novel 1-(substituted benzylidene)-3-(1-(morpholino/piperidino methyl)-2,3-dioxoindolin-5-yl)urea derivatives.
Topics: Animals; Anticonvulsants; Electroshock; Epilepsy; Humans; Isatin; Male; Mice; Morpholinos; Piperidin | 2011 |
Design, synthesis and anticonvulsant evaluation of novel N-(4-substituted phenyl)-2-[4-(substituted) benzylidene]-hydrazinecarbothio amides.
Topics: Animals; Anticonvulsants; Drug Design; Epilepsy; Hydrogen Bonding; Male; Mice; Models, Molecular; Pr | 2012 |
Synthesis and anticonvulsant activity of novel 2,6-diketopiperazine derivatives. Part 2: Perhydropyrido[1,2-a]pyrazines.
Topics: Animals; Anticonvulsants; Biological Assay; Diketopiperazines; Electroshock; Epilepsy; Magnetic Reso | 2012 |
Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).
Topics: Absorption; Amides; Animals; Anticonvulsants; Dioxanes; Dogs; Drug Evaluation, Preclinical; Drug Res | 2013 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ep | 2014 |
Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents.
Topics: Animals; Anticonvulsants; Carbamates; Drug Design; Electroshock; Epilepsy; Mice; Pentylenetetrazole; | 2015 |
Discovery of benzothiazine derivatives as novel, orally-active anti-epileptic drug candidates with broad anticonvulsant effect.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, | 2015 |
Electronic Health Record Interoperability-Why Electronically Discontinued Medications Are Still Dispensed.
Topics: Accidental Falls; Aged; Anticonvulsants; Clinical Pharmacy Information Systems; Deprescriptions; Dru | 2021 |
The epilepsy-movement disorder phenotypic spectrum and phenytoin-induced dyskinesia associated with GABRB3 pathogenic variants.
Topics: Dyskinesia, Drug-Induced; Epilepsy; Humans; Movement Disorders; Phenytoin; Receptors, GABA-A | 2021 |
Patient, Disease, and Drug-Related Risk Factors Associated with Phenytoin- Induced Cutaneous Adverse Drug Reactions in South Indian Epileptic Patients - A Prospective Case-Control Study.
Topics: Adult; Anticonvulsants; Case-Control Studies; Drug-Related Side Effects and Adverse Reactions; Epile | 2022 |
Use of Saliva as an Alternative Matrix to Serum/Plasma for Therapeutic Drug Monitoring Using Reverse-Phase HPLC.
Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Drug Monitoring; Epilepsy; Hum | 2021 |
Nesfatin-1 ameliorates oxidative brain damage and memory impairment in rats induced with a single acute epileptic seizure.
Topics: Animals; Anticonvulsants; Brain Injuries; Epilepsy; Glutathione; Male; Memory Disorders; Neuroprotec | 2022 |
Incidence of Antiseizure Medication-Induced Severe Cutaneous Adverse Reactions in Malaysia.
Topics: Anticonvulsants; Drug Eruptions; Epilepsy; HLA Antigens; Humans; Incidence; Lamotrigine; Malaysia; P | 2022 |
Clinical Evaluation of Levetiracetam in the Treatment of Epilepsy.
Topics: Anticonvulsants; Epilepsy; Humans; Levetiracetam; Phenytoin; Valproic Acid | 2022 |
Exome sequencing allows detection of relevant pharmacogenetic variants in epileptic patients.
Topics: Epilepsy; Exome; Humans; Pharmacogenomic Variants; Phenytoin; Retrospective Studies | 2022 |
The treatment of epilepsy in younger and older adults: Demographic differences and prescribing patterns of anti-seizure medications in Canada.
Topics: Aged; Anticonvulsants; Comorbidity; Demography; Drug Prescriptions; Epilepsy; Female; Humans; Male; | 2022 |
Multimorbidity and chronic co-prescription networks and potential interactions in adult patients with epilepsy: MorbiNet study.
Topics: Adult; Comorbidity; Dementia; Epilepsy; Humans; Multimorbidity; Phenytoin; Prescriptions | 2022 |
Long-Term Effects of Antiseizure Medications.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenytoin; Seizures | 2022 |
Trimetazidine, an Anti-Ischemic Drug, Reduces the Antielectroshock Effects of Certain First-Generation Antiepileptic Drugs.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res | 2022 |
Ranolazine Interacts Antagonistically with Some Classical Antiepileptic Drugs-An Isobolographic Analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res | 2022 |
A real-life pilot study of the clinical application of pharmacogenomics testing on saliva in epilepsy.
Topics: Anticonvulsants; Clobazam; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C | 2023 |
Calcium Phosphate-Based Nanoformulation Selectively Abolishes Phenytoin Resistance in Epileptic Neurons for Ceasing Seizures.
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Phosphates; Epilep | 2023 |
ROS/Electro Dual-Reactive Nanogel for Targeting Epileptic Foci to Remodel Aberrant Circuits and Inflammatory Microenvironment.
Topics: Anticonvulsants; Epilepsy; Humans; Nanogels; Phenytoin; Reactive Oxygen Species | 2023 |
Valproate-related hyperammonemic encephalopathy with generalized suppression EEG: a case report.
Topics: Adult; Anticonvulsants; Brain Diseases; Electroencephalography; Epilepsy; Female; Humans; Hyperammon | 2023 |
External validation of the AntiEpileptic Drug Monitoring in PREgnancy (EMPiRE) model for predicting seizures in pregnant women with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Cohort Studies; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam | 2023 |
Evolution of antiseizure medication use and cost in the United States of America 2006-2021.
Topics: Adult; Anticonvulsants; Child; Drugs, Generic; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; | 2023 |
Antiepileptic drug-induced psychosis associated with MTHFR C677T: a case report.
Topics: Adolescent; Anticonvulsants; Avitaminosis; Epilepsy; Humans; Male; Methylenetetrahydrofolate Reducta | 2019 |
An infant with epilepsy: don't forget the importance of skin examination.
Topics: Anticonvulsants; Diagnosis, Differential; Epilepsy; Female; Hemimegalencephaly; Humans; Hypopigmenta | 2019 |
Elevated serum alkaline phosphatase in epilepsy: effect of age and treatment.
Topics: Adolescent; Adult; Age Factors; Alkaline Phosphatase; Anticonvulsants; Carbamazepine; Child; Child, | 2020 |
Hippocampal low-frequency stimulation improves cognitive function in pharmacoresistant epileptic rats.
Topics: Animals; Anticonvulsants; Cognition; Disease Models, Animal; Electric Stimulation; Epilepsy; Hippoca | 2020 |
Budget Impact Analysis of Extended-Release Phenytoin Capsules Compared With Immediate-Release Phenytoin Capsules for Patients With Epilepsy in Thailand.
Topics: Anticonvulsants; Capsules; Delayed-Action Preparations; Epilepsy; Humans; National Health Programs; | 2020 |
Genotoxicity assessment of antiepileptic drugs (AEDs) in human embryonic stem cells.
Topics: Anticonvulsants; Carbamazepine; DNA Damage; Epilepsy; Female; Human Embryonic Stem Cells; Humans; La | 2019 |
Levetiracetam is a useful alternative to phenytoin for epileptic seizures in children.
Topics: Child; Epilepsy; Humans; Levetiracetam; Phenytoin; Seizures; Status Epilepticus | 2019 |
Paradoxical deterioration in seizure control due to anticonvulsant-induced hypocalcaemia.
Topics: Anticonvulsants; Diagnosis, Differential; Epilepsy; Humans; Hypocalcemia; Male; Middle Aged; Phenyto | 2019 |
Drug therapy problems and treatment satisfaction among ambulatory patients with epilepsy in a specialized hospital in Ethiopia.
Topics: Adolescent; Adult; Ambulatory Care Facilities; Anticonvulsants; Cross-Sectional Studies; Drug Intera | 2020 |
Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anticonvulsants; Corticosterone; Depression; Dose- | 2020 |
Diagnostic evaluation and management of seizures and status epilepticus in children with known epilepsy or new-onset seizures: A retrospective and comparative analysis.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clonazepam; Diazepam; Epilepsy; Female; Hospit | 2020 |
Nanocage encapsulation improves antiepileptic efficiency of phenytoin.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri | 2020 |
Patterns of antiepileptic drug use among elderly patients with epilepsy: 2004-2015.
Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Epilepsy; F | 2020 |
Refractory Bullous Pemphigoid Improved by Discontinuation of Phenytoin as an CYP3A4 Inducer.
Topics: Aged; Anti-Inflammatory Agents; Anticonvulsants; Cerebral Palsy; Cytochrome P-450 CYP3A Inducers; Dr | 2020 |
Influence of dose and antiepileptic comedication on brivaracetam serum concentrations in patients with epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dibenzazepines; Drug Interactions; D | 2020 |
Paediatric status epilepticus: finally, some evidence-based treatment guidance, but still a long way to go.
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Emergency Treatment; Epilepsy | 2020 |
Effects of antiepileptic drugs on electroencephalography (EEG): Insights and applicability.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Electroencephalography; Epilepsy | 2020 |
Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database.
Topics: Anticonvulsants; Carbamazepine; Clobazam; Clonazepam; Databases, Factual; Drug Therapy, Combination; | 2020 |
Therapeutic Monitoring of Lacosamide in Japanese Patients With Epilepsy: Clinical Response, Tolerability, and Optimal Therapeutic Range.
Topics: Adult; Anticonvulsants; Asian People; Carbamazepine; Drug Interactions; Drug Monitoring; Drug Therap | 2020 |
Influenza immunization does not predominantly alter levels of phenytoin, and cytochrome P-450 enzymes in epileptic patients receiving phenytoin monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Cytochrome P-450 CYP2C9; Epilepsy; Female; Genotype; Humans; Imm | 2020 |
Pharmacokinetics, tolerability, and clinical effectiveness of perampanel in Japanese patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Drug Monitoring; Drug T | 2020 |
Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Epoxide Hydrolases; Humans; Phenytoin | 2021 |
Developing precision treatments for epilepsy using patient and animal models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Humans; Lamotrigine; Phenytoin | 2021 |
Potential induction of epileptic spasms by nonselective voltage-gated sodium channel blockade: Interaction with etiology.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Phenytoin; Spasm; Spasms, Infantile; Voltage-Gated Sodium | 2021 |
Gingival overgrowth induced by anticonvulsant drugs: A cross-sectional study on epileptic patients.
Topics: Anticonvulsants; Cross-Sectional Studies; Epilepsy; Female; Gingival Overgrowth; Humans; Male; Pheny | 2021 |
Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats.
Topics: Adjuvants, Pharmaceutic; Animals; Anticonvulsants; Behavior, Animal; Centella; Cognitive Dysfunction | 2021 |
Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2021 |
Gene Expression Analysis Identifies Cholesterol Metabolism Dysregulation in Hippocampus of Phenytoin-Resistant Pentylenetetrazol-Kindled Epileptic Mice.
Topics: Animals; Anticonvulsants; Cholesterol; Epilepsy; Gene Expression; Hippocampus; Humans; Kindling, Neu | 2021 |
To determine the effect of long-term antiepileptic drug on the serum folate and vitamin B12 among epileptic patients.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Folic Acid; Humans; Male; Middle Aged; Phenytoin; Vitamin | 2021 |
Effects of antiepileptic drugs' administration during pregnancy on the nerve cell proliferation and axonal outgrowth of human neuroblastoma SH-SY5Y nerve cells.
Topics: Anticonvulsants; Carbamazepine; Cell Line, Tumor; Cell Proliferation; Child; Epilepsy; Female; Human | 2021 |
Post-stroke epilepsy and antiepileptic drug use in men and women.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Lamotrigin | 2021 |
pH-induced homogeneous liquid-liquid microextraction method based on new switchable deep eutectic solvent for the extraction of three antiepileptic drugs from breast milk.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Hydrogen-Ion Concentration; Lamotrigine; Liquid Phase Mic | 2021 |
Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsy; Levetiracetam; Pharmaceut | 2021 |
Lack of pathogenic mutations in SOS1 gene in phenytoin-induced gingival overgrowth patients.
Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Chromatography, High Pressure Liquid; Epil | 2017 |
Fetal Hydantoin Syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Administration, Oral; Epilepsy; Female; Humans | 2017 |
Phenytoin Toxicity.
Topics: Airway Extubation; Anticonvulsants; Drug Administration Schedule; Epilepsy; Humans; Lung Diseases, O | 2017 |
Fosphenytoin-induced purple glove syndrome: A case report.
Topics: Aged; Anticonvulsants; Edema; Epilepsy; Humans; Male; Phenytoin; Skin Diseases; Upper Extremity | 2017 |
Risk of angioedema associated with levetiracetam compared with phenytoin: Findings of the observational health data sciences and informatics research network.
Topics: Angioedema; Community Networks; Databases, Factual; Epilepsy; Female; Humans; Levetiracetam; Male; P | 2017 |
Homocysteine Metabolism and Hematological Parameters in Early Stage of Phenytoin Treated Epileptic Children.
Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Phe | 2017 |
Drug rash with eosinophilia and systemic symptoms (DRESS) caused by phenytoin.
Topics: Adult; Anti-Inflammatory Agents; Anticonvulsants; Diagnosis, Differential; Drug Hypersensitivity Syn | 2017 |
Preliminary study of the association between the elimination parameters of phenytoin and phenobarbital.
Topics: Adult; Anticonvulsants; Drug Monitoring; Epilepsy; Female; Humans; Linear Models; Male; Middle Aged; | 2017 |
Evaluation of phenytoin serum levels following a loading dose in the acute hospital setting.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Community Health Planning; Epile | 2017 |
Effects of the Antiepileptic Drugs Phenytoin, Gabapentin, and Levetiracetam on Bone Strength, Bone Mass, and Bone Turnover in Rats.
Topics: Administration, Oral; Amines; Animals; Anticonvulsants; Bone Density; Bone Remodeling; Bone Resorpti | 2017 |
Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Avoidance Learning; Brain; Disease Models, Animal; | 2017 |
Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach.
Topics: Acetaminophen; Animals; Biological Transport; Brain; Brain Injuries, Traumatic; Central Nervous Syst | 2018 |
Phenytoin-related ataxia in patients with epilepsy: clinical and radiological characteristics.
Topics: Antibodies; Anticonvulsants; Ataxia; Brain; Epilepsy; Female; Folic Acid; Gliadin; GTP-Binding Prote | 2018 |
Therapeutic Drug Monitoring of Phenytoin by Simple, Rapid, Accurate, Highly Sensitive and Novel Method and Its Clinical Applications.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Chromatography, Liquid; Drug Moni | 2017 |
Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug | 2018 |
The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy.
Topics: Action Potentials; Animals; Anticonvulsants; Brain Diseases; Disease Models, Animal; Drug Administra | 2018 |
Incidence of Stevens-Johnson syndrome following combination drug use of allopurinol, carbamazepine and phenytoin in Taiwan: A case-control study.
Topics: Adult; Aged; Allopurinol; Anticonvulsants; Carbamazepine; Case-Control Studies; Drug Combinations; E | 2018 |
Phenytoin induced dystonia.
Topics: Anticonvulsants; Child, Preschool; Dystonia; Epilepsy; Humans; Male; Phenytoin; Primidone | 2018 |
Evaluation of a lymphocyte transformation test and cytokine detection assay to identify phenytoin and carbamazepine provoked DRESS or SJS/TEN in epilepsy patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Cytokines; Drug Hypersensitivity Syndrome; Epilepsy; Female; | 2018 |
Frequency of drug combinations between enzyme-inducing first-generation antiepileptic drugs and inducible drugs in patients with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Cytochrome P-450 Enzyme Inducers; Drug Interactions; Drug Therapy, C | 2018 |
Levetiracetam Induced Neuropsychiatric Manifestation in a 5-year-old Boy.
Topics: Anticonvulsants; Behavior; Child, Preschool; Cognitive Dysfunction; Epilepsy; Humans; Levetiracetam; | 2019 |
Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood-brain barrier model.
Topics: Anticonvulsants; Astrocytes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformat | 2018 |
Drug-drug interactions among drugs prescribed for nontuberculous mycobacterial infection and epilepsy: A case report.
Topics: Aged; Anti-Bacterial Agents; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; E | 2019 |
Hypothyroidism induced by phenytoin and gabapentin: A Case Report.
Topics: Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobutyric | 2018 |
Evaluation of Intravenous Phenytoin and Fosphenytoin Loading Doses: Influence of Obesity and Sex.
Topics: Administration, Intravenous; Adult; Aged; Anticonvulsants; Body Mass Index; Dose-Response Relationsh | 2019 |
HLA-B*5701 and HLA-B*5801 in an Indian patient with anti-epileptics induced cutaneous adverse drug reactions.
Topics: Acute Generalized Exanthematous Pustulosis; Alleles; Anticonvulsants; Carbamazepine; Epilepsy; Genet | 2019 |
Fetal antiepileptic drug exposure and learning and memory functioning at 6 years of age: The NEAD prospective observational study.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Lamotrigine; Learning; Memor | 2019 |
Effects of Sodium Valproate, Levetiracetam and Phenytoin Therapy on Evoked Potentials in Children with Epilepsy.
Topics: Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Evoked Potentials; Humans; L | 2019 |
Optimal Dosing Regimen of Phenytoin for Korean Epilepsy Patients: From Premature Babies to the Elderly.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Body Weight; Child; Child, Preschool; D | 2019 |
Influence of etiology on treatment choices for neonatal seizures: A survey among pediatric neurologists.
Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infant; Infant, | 2019 |
Pharmacotherapy and electroencephalographic evolution in SCN8A encephalopathy: A case report.
Topics: Anticonvulsants; Brain Diseases; Diagnosis, Differential; Electroencephalography; Epilepsy; Humans; | 2019 |
Estimation of Phenytoin Pharmacokinetic Parameters in Saudi Epileptic Patients.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Biological Variation, Popu | 2019 |
The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling, | 2019 |
Population Pharmacokinetic Analysis of Phenytoin After Intravenous Administration of Fosphenytoin in Adult and Elderly Epileptic Patients.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Anticonvulsants; Epilepsy; Female; Huma | 2019 |
Uncommon Treatable Genetic Epileptic Encephalopathies.
Topics: Anticonvulsants; Epilepsy; Genetic Markers; Humans; India; Infant; KCNQ2 Potassium Channel; Mutation | 2019 |
Management and attitudes toward patients with epilepsy in general practice: How far have we come in three decades?
Topics: Adult; Anticonvulsants; Attitude of Health Personnel; Australia; Carbamazepine; Clinical Competence; | 2019 |
FGF12p.Gly112Ser variant as a cause of phenytoin/phenobarbital responsive epilepsy.
Topics: Alleles; Amino Acid Substitution; Anticonvulsants; Child, Preschool; Electroencephalography; Epileps | 2019 |
Risk factors for hyperammonemia in pediatric patients with epilepsy.
Topics: Acetazolamide; Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Dose-Response Rela | 2013 |
Multidrug resistance-associated protein 1 decreases the concentrations of antiepileptic drugs in cortical extracellular fluid in amygdale kindling rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Epilepsy; Extracellular Fluid; Hippocampus | 2013 |
When less is more: a case of phenytoin toxicity.
Topics: Aged, 80 and over; Anticonvulsants; Epilepsy; Humans; Male; Phenytoin | 2013 |
HLA typing in Brazilian boys with aromatic antiepileptic drug-induced DRESS.
Topics: Alleles; Anticonvulsants; Brazil; Carbamazepine; Child; Drug Eruptions; Eosinophilia; Epilepsy; Hist | 2013 |
Phenytoin-induced gingival enlargement: a dental awakening for patients with epilepsy.
Topics: Adult; Anticonvulsants; Epilepsy; Gingival Hyperplasia; Humans; Male; Phenytoin | 2013 |
Fosphenytoin induced transient pendular nystagmus.
Topics: Anticonvulsants; Brain; Epilepsy; Humans; Infusions, Intravenous; Magnetic Resonance Imaging; Male; | 2013 |
Studies on pharmacokinetic mechanism of phenytoin resistance in refractory epilepsy.
Topics: Administration, Oral; Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member | 2013 |
Anonychia due to prenatal phenytoin exposure.
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Nails, Malformed; Phenytoin; Pregnancy; Pregnancy | 2012 |
Intravenous phenytoin: a retrospective analysis of Bayesian forecasting versus conventional dosing in patients.
Topics: Age Factors; Anticonvulsants; Bayes Theorem; Cohort Studies; Dose-Response Relationship, Drug; Drug | 2013 |
Use of antiepileptic drugs and risk of hypothyroidism.
Topics: Anticonvulsants; Databases, Factual; Epilepsy; Humans; Hypothyroidism; Phenytoin; Risk Factors; Taiw | 2013 |
Noninvasive screening for preclinical atherosclerosis in children on phenytoin or carbamazepine monotherapy: a cross sectional study.
Topics: Anticonvulsants; Atherosclerosis; Carbamazepine; Carotid Arteries; Carotid Intima-Media Thickness; C | 2013 |
A case of selective immunoglobulin A deficiency with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.
Topics: Antibodies, Antineutrophil Cytoplasmic; Antibodies, Antinuclear; Anticonvulsants; Epilepsy; Female; | 2014 |
All in his head: an unexpected space-occupying lesion.
Topics: Aged; Anti-Infective Agents; Anticonvulsants; Brain Abscess; Ceftriaxone; Craniotomy; Drainage; Epil | 2014 |
Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation.
Topics: Amines; Animals; Anticonvulsants; Astrocytes; Blotting, Western; Carbamazepine; Cells, Cultured; Coc | 2014 |
P-glycoprotein alters blood-brain barrier penetration of antiepileptic drugs in rats with medically intractable epilepsy.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri | 2013 |
Drug interaction between phenytoin and valproic acid in a child with refractory epilepsy: a case report.
Topics: Anticonvulsants; Child; Drug Interactions; Epilepsy; Female; Humans; Phenytoin; Valproic Acid | 2014 |
Hemodialysis effects on phenytoin pharmacokinetics.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Kidney Failure, Chronic; Male; Phenytoin; Renal Dialysis | 2014 |
Efficacy of dexamethasone on penicillin-induced epileptiform activity in rats: an electrophysiological study.
Topics: Animals; Anticonvulsants; Brain; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, | 2014 |
Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs.
Topics: Acetamides; Adult; Aged; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Inte | 2014 |
EMPACT syndrome: limited evidence despite a high-risk cohort.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Neoplasms; Child; Cranial Irradia | 2014 |
Laser light scan analysis of the "anticonvulsant face".
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Case-Control Studies; Child; Cohort Studie | 2014 |
4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy.
Topics: Alleles; Amino-Acid N-Acetyltransferase; Ammonia; Anticonvulsants; Asian People; Biomarkers, Pharmac | 2014 |
Adjuvant anticholinesterase therapy for the management of epilepsy-induced memory deficit: a critical pre-clinical study.
Topics: Animals; Anticonvulsants; Atropine; Chemotherapy, Adjuvant; Cholinesterase Inhibitors; Epilepsy; Mal | 2014 |
Reboxetine and its influence on the action of classical antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Drug Interactions; Electrosh | 2014 |
Profound reduction in the tamoxifen active metabolite endoxifen in a patient on phenytoin for epilepsy compared with a CYP2D6 genotype matched cohort.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Cohort Studies; Cytochrome P-450 CYP2D6; Drug Inte | 2014 |
[Epilepsy in the child and in the adult. Part 1. Epilepsy in the child].
Topics: Anticonvulsants; Benzodiazepines; Child; Electroencephalography; Epilepsy; Follow-Up Studies; Humans | 2014 |
A young woman with seizures and psychosis.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Hallucinations; Humans; Levetiracetam; Neuropsychological | 2014 |
Angiopep-conjugated electro-responsive hydrogel nanoparticles: therapeutic potential for epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Blood-Brain Barrier; Cell Line; Drug Delivery Systems; Electrici | 2014 |
Phenytoin-induced severe gingival overgrowth in a child.
Topics: Anticonvulsants; Child; Diagnosis, Differential; Epilepsy; Gingival Overgrowth; Humans; Male; Oral H | 2014 |
Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri | 2014 |
The P value: probable does not mean practical.
Topics: Anticonvulsants; Epilepsy; Humans; Phenytoin; Probability; Statistics, Nonparametric | 2014 |
Erythematous-to-brownish plaques on the upper back: a quiz. Phenytoin-induced T-cell predominant pseudolymphoma (“pseudomycosis fungoides”) with T-cell clonality.
Topics: Adult; Anticonvulsants; Biopsy; Drug Eruptions; Epilepsy; Erythema; Female; Humans; Immunophenotypin | 2015 |
Individualized phenytoin therapy for Japanese pediatric patients with epilepsy based on CYP2C9 and CYP2C19 genotypes.
Topics: Adolescent; Alleles; Anticonvulsants; Asian People; Child; Child, Preschool; Cytochrome P-450 CYP2C1 | 2015 |
Effect of comedication on lamotrigine clearance in Korean epilepsy patients.
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Half- | 2015 |
Clinical validation and implications of dried blood spot sampling of carbamazepine, valproic acid and phenytoin in patients with epilepsy.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Dried Blood Spot Testing; Drug Monitoring; Drug Therapy | 2014 |
Switching between phenytoin generics in patients with epilepsy may lead to increased risk of breakthrough seizure: chart analysis and practice recommendations.
Topics: Adult; Aged; Anticonvulsants; Biological Availability; Drug Monitoring; Drug Substitution; Epilepsy; | 2014 |
The effect of polymorphic metabolism enzymes on serum phenytoin level.
Topics: Adult; Alleles; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Epilepsy; Female; Genotype; Human | 2015 |
Chronic administration of phenytoin induces efflux transporter overexpression in rats.
Topics: Administration, Oral; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Membe | 2014 |
Concurrence of myotonic dystrophy and epilepsy: a case report.
Topics: Adult; Anticonvulsants; Electromyography; Epilepsy; Ethiopia; Humans; Male; Myotonic Dystrophy; Phen | 2014 |
Cosmetic side effects of antiepileptic drugs in adults with epilepsy.
Topics: Acne Vulgaris; Adult; Alopecia; Anticonvulsants; Epilepsy; Female; gamma-Aminobutyric Acid; Gingival | 2015 |
Effects of phenytoin and valproic acid on cognitive functions of Thai epileptic patients: a pilot study.
Topics: Adolescent; Adult; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Cognition; Ep | 2014 |
[Follow-up of a cohort of patients after substitution of phenytoin for phenytoin sodium in an epilepsy center].
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Dosage Forms; Dose-Response Relationship, Drug; Dru | 2015 |
Preliminary anticonvulsant and toxicity screening of substituted benzylidenehydrazinyl-N-(6-substituted benzo[d]thiazol-2-yl)propanamides.
Topics: Animals; Anticonvulsants; Benzothiazoles; Binding Sites; Dose-Response Relationship, Drug; Drug Eval | 2014 |
Comparative behavioral and neurochemical analysis of phenytoin and valproate treatment on epilepsy induced learning and memory deficit: Search for add on therapy.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Cerebral Cortex; Drug Therapy, Combination; Epilepsy | 2015 |
Clinical relevance of genetic polymorphism in CYP2C9 gene to pharmacodynamics and pharmacokinetics of phenytoin in epileptic patients: validatory pharmacogenomic approach to pharmacovigilance.
Topics: Anticonvulsants; Area Under Curve; Biotransformation; Case-Control Studies; Cytochrome P-450 CYP2C9; | 2015 |
Association analysis of CYP2C9*3 and phenytoin-induced severe cutaneous adverse reactions (SCARs) in Thai epilepsy children.
Topics: Anticonvulsants; Child; Child, Preschool; Cytochrome P-450 CYP2C9; Drug Eruptions; Epilepsy; Female; | 2015 |
Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, | 2015 |
Paradoxical Seizure Response to Phenytoin in an Epileptic Heroin Addict.
Topics: Adult; Anticonvulsants; Epilepsy; Heroin Dependence; Humans; Male; Phenytoin; Seizures | 2015 |
CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Case-Contro | 2016 |
Potentially Unsafe Herb-drug Interactions Between a Commercial Product of Noni Juice and Phenytoin- A Case Report.
Topics: Cytochrome P-450 CYP1A2 Inducers; Cytochrome P-450 CYP2C9 Inducers; Epilepsy; Fruit and Vegetable Ju | 2015 |
Remarkable Phenytoin Sensitivity in 4 Children with SCN8A-related Epilepsy: A Molecular Neuropharmacological Approach.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Mutation, Missense; NAV1.6 | 2016 |
Effect of carbamazepine or phenytoin therapy on blood level of intravenously administered midazolam: a prospective cohort study.
Topics: Administration, Intravenous; Adult; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Therapy, Co | 2016 |
Identifying Reverse Malingering in the Civilian Occupational Setting.
Topics: Adult; Anticonvulsants; Attitude to Health; Confidentiality; Disclosure; Epilepsy; Humans; Male; Mal | 2016 |
Fluoxetine-induced phenytoin toxicity: a clinical reminder about the perils of polypharmacy.
Topics: Antidepressive Agents, Second-Generation; Drug Interactions; Epilepsy; Female; Fluoxetine; Humans; M | 2015 |
Effect observation of anti epileptic drugs on serum folic acid and vitamin B12 of epileptic patients.
Topics: Adult; Anticonvulsants; Biomarkers; Case-Control Studies; Drug Monitoring; Epilepsy; Female; Folic A | 2015 |
Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy.
Topics: Adolescent; Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Carbamazepine; Ch | 2015 |
Concentration of antiepileptic drugs in persons with epilepsy: a comparative study in serum and saliva.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Middle Age | 2016 |
Synaptic vesicle protein2A decreases in amygdaloid-kindling pharmcoresistant epileptic rats.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Drug Resistance; Electric Stimulation; E | 2015 |
Comparing paediatric intravenous phenytoin doses using physiologically based pharmacokinetic (PBPK) modelling software.
Topics: Administration, Intravenous; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, D | 2015 |
Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzothiazoles; Disease Models, Animal; Dose-Response | 2016 |
Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy.
Topics: Adolescent; Ammonia; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Genotype; Glutamate | 2015 |
What is This Rash?
Topics: Adrenal Cortex Hormones; Adult; Anticonvulsants; Drug Hypersensitivity Syndrome; Drug Substitution; | 2016 |
Phenytoin neurotoxicity in a child carrying new STXBP1 and CYP2C9 gene mutations.
Topics: Anticonvulsants; Child; Child, Preschool; Cytochrome P-450 CYP2C9; Epilepsy; Humans; Infant; Infant, | 2016 |
Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fructose; Humans; Male; M | 2016 |
The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy.
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool; Clobazam; Clon | 2016 |
Medication prescribing and patient-reported outcome measures in people with epilepsy in Bhutan.
Topics: Adult; Aged; Anticonvulsants; Bhutan; Carbamazepine; Drug Prescriptions; Electroencephalography; Epi | 2016 |
Frequencies of CYP2C9 polymorphisms in North Indian population and their association with drug levels in children on phenytoin monotherapy.
Topics: Anticonvulsants; Child; Child, Preschool; Cross-Sectional Studies; Cytochrome P-450 CYP2C9; Epilepsy | 2016 |
Evaluating the Role of Genetic Variants on first-line antiepileptic drug response in North India: Significance of SCN1A and GABRA1 Gene Variants in Phenytoin Monotherapy and its Serum Drug Levels.
Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; India; Male; NAV1.1 Voltage-Gat | 2016 |
Development, validation and clinical application of an online-SPE-LC-HRMS/MS for simultaneous quantification of phenobarbital, phenytoin, carbamazepine, and its active metabolite carbamazepine 10,11-epoxide.
Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Epilep | 2016 |
Lacking the 'protective label' of diabetes: Phenytoin-induced distal symmetrical peripheral neuropathy. A clinical case report.
Topics: Amputation, Surgical; Anticonvulsants; Epilepsy; Foot Ulcer; Gas Gangrene; Humans; Male; Middle Aged | 2016 |
Epilepsy in Adults with Supratentorial Glioblastoma: Incidence and Influence Factors and Prophylaxis in 184 Patients.
Topics: Adult; Aged; Anticonvulsants; Craniotomy; Epilepsy; Female; Frontal Lobe; Glioblastoma; Humans; Male | 2016 |
Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study.
Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilep | 2016 |
Hyperhomocysteinaemia in children receiving phenytoin and carbamazepine monotherapy: a cross-sectional observational study.
Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Child, Preschool; Cross-Sectional Studi | 2017 |
Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population-based case-control study.
Topics: Adult; Aged; Anticonvulsants; Carcinoma, Hepatocellular; Case-Control Studies; Epilepsy; Humans; Liv | 2016 |
Reversible lesion involving the splenium of the corpus callosum caused by phenytoin sodium withdrawal.
Topics: Anticonvulsants; Brain Diseases; Corpus Callosum; Diagnosis, Differential; Epilepsy; Humans; Male; M | 2017 |
Utility of Magnetic Resonance Imaging in the Surgical Management of Drug Extravasation: A Case Report.
Topics: Adult; Anticonvulsants; Debridement; Epilepsy; Extravasation of Diagnostic and Therapeutic Materials | 2017 |
Population Pharmacokinetics of Topiramate in Japanese Pediatric and Adult Patients With Epilepsy Using Routinely Monitored Data.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Asian People; Body Weight; Carbamazepine; Child; Child, Pr | 2017 |
Prevalence of cardiovascular risk factors in people with epilepsy.
Topics: Adult; Aged; Anticonvulsants; Cardiovascular Diseases; Comorbidity; Dyslipidemias; Epilepsy; Female; | 2017 |
Phenytoin half-life and clearance during maintenance therapy in adults and elderly patients with epilepsy.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anticonvulsants; Drug Admi | 2008 |
Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Genetic Predisposition t | 2008 |
Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins.
Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Cysteine; Dipeptides; Drug Evaluation; | 2008 |
Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain; Brain Injuries; Drug Tolerance; Drug-Related | 2008 |
Levetiracetam as a possible cause of fulminant liver failure.
Topics: Adult; Anticonvulsants; Brain; Epilepsy; Humans; Levetiracetam; Liver; Liver Failure, Acute; Liver F | 2008 |
Agranulocytosis following phenytoin-induced hypersensitivity syndrome.
Topics: Agranulocytosis; Anti-Bacterial Agents; Anticonvulsants; Cefepime; Cephalosporins; Chemical and Drug | 2009 |
Severe postictal laryngospasm as a potential mechanism for sudden unexpected death in epilepsy: a near-miss in an EMU.
Topics: Adult; Anticonvulsants; Death, Sudden; Electroencephalography; Epilepsy; Humans; Laryngismus; Male; | 2008 |
Treatment of epileptics with epanutin.
Topics: Epilepsy; Humans; Phenytoin | 1947 |
Effect of phenytoin and valproic acid therapy on serum lipid levels and liver function tests.
Topics: Anticonvulsants; Case-Control Studies; Child; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Epile | 2008 |
Phenytoin toxicity due to genetic polymorphism.
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Brain Injuries; Cytochrome P-450 CYP2C9; Epilepsy; F | 2009 |
Dose adjustment of phenytoin for comedication in Japanese patients with epilepsy.
Topics: Adult; Aged; Aging; Algorithms; Anticonvulsants; Body Surface Area; Body Water; Body Weight; Drug In | 2009 |
Synthesis and anticonvulsant activity of 5-chloro-2(3H)-benzoxazolinone-3-acetyl-2-(o/p-substituted benzal) hydrazone derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Epilepsy; Hydrazones; Magnetic Resonance Spectroscopy; Male; | 2008 |
Drug treatment of epilepsy in the century of the ILAE: the first 50 years, 1909-1958.
Topics: Advertising; Anticonvulsants; Bromides; Epilepsy; Herbal Medicine; History, 18th Century; History, 1 | 2009 |
Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Child, Preschool; Cognition; Developmental Disabilities; Dose | 2009 |
Anticonvulsant effect of Ficus religiosa: role of serotonergic pathways.
Topics: Animals; Anticonvulsants; Cyproheptadine; Diazepam; Disease Models, Animal; Dose-Response Relationsh | 2009 |
Intestinal obstruction and phenytoin intoxication.
Topics: Anticonvulsants; Comorbidity; Epilepsy; Female; Half-Life; Humans; Intestinal Absorption; Intestinal | 2009 |
Bone disease induced by phenytoin therapy: clinical and experimental study.
Topics: Adult; Aged; Animals; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Epilepsy; Female; Femu | 2009 |
Guidelines for diagnosis and management of childhood epilepsy.
Topics: Algorithms; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Hu | 2009 |
Differences between the measured and calculated free serum phenytoin concentrations in epileptic patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle | 2009 |
COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri | 2010 |
The little compound that could: how phenytoin changed drug discovery and development.
Topics: Anticonvulsants; Drug Discovery; Epilepsy; History, 20th Century; Humans; Phenytoin; United States | 2009 |
Phenytoin toxicity and thyroid dysfunction.
Topics: Anticonvulsants; Epilepsy; Female; Follow-Up Studies; Humans; Hypothyroidism; Middle Aged; Phenytoin | 2009 |
CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose.
Topics: Anticoagulants; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Base Sequence; Cytochrome P-450 CYP2 | 2010 |
Utility of levetiracetam in patients with subarachnoid hemorrhage.
Topics: Adult; Aged; Anticonvulsants; Epilepsy; Female; Follow-Up Studies; Humans; Levetiracetam; Male; Midd | 2009 |
Effect of pharmacist participation in the health care team on therapeutic drug monitoring utilization for antiepileptic drugs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Chi-Square Distribution; | 2009 |
Valproic acid: long-term effects on children exposed in utero.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Contraindications; Dose | 2009 |
Adverse effects of carbamazepine, phenytoin, valproate and lamotrigine monotherapy in epileptic adult Chinese patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; China; Drug Eruptions; Epilepsy; Female; Hu | 2010 |
Sporadic hemiplegic migraine and epilepsy associated with CACNA1A gene mutation.
Topics: Adult; Anticonvulsants; Calcium Channels; Chromosomes, Human, Pair 19; Epilepsy; Female; Humans; Inj | 2010 |
Anticonvulsant activity of DNS II fraction in the acute seizure models.
Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbre | 2010 |
Reduced phenytoin levels in an epileptic patient following Roux-En-Y gastric bypass for obesity.
Topics: Anticonvulsants; Body Mass Index; Epilepsy; Gastric Bypass; Humans; Lamotrigine; Male; Middle Aged; | 2011 |
Dilantin in the treatment of epilepsy.
Topics: Epilepsy; Humans; Phenytoin | 1947 |
Isopropyl alcohol, other ketogens, and miscellaneous agents on thresholds for electrical convulsions and diphenylhydantoin.
Topics: 2-Propanol; Epilepsy; Humans; Ketone Bodies; Phenytoin; Seizures; Therapeutics | 1947 |
Dilantin treatment for behavior problem children with abnormal electroencephalograms.
Topics: Brain; Child; Electroencephalography; Epilepsy; Humans; Mental Disorders; Phenytoin | 1947 |
Tridione-diphenylhydantoin combination therapy in grand mal with slow-wave EEG dysrhythmia.
Topics: Combined Modality Therapy; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenyto | 1947 |
Determination of free and total levels of phenytoin in human plasma from patients with epilepsy by MEKC: an adequate alternative to HPLC.
Topics: Adult; Calibration; Chromatography, High Pressure Liquid; Chromatography, Micellar Electrokinetic Ca | 2010 |
Intracerebral hemorrhage and seizures.
Topics: Anticonvulsants; Cerebral Hemorrhage; Epilepsy; Humans; Phenytoin; Prevalence | 2010 |
Comparative effectiveness of 10 antiepileptic drugs in older adults with epilepsy.
Topics: Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dose-Response Rela | 2010 |
Influence of CYP2C9 and CYP2C19 genetic polymorphisms on phenytoin-induced neurological toxicity in Indian epileptic patients.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Epilepsy; F | 2010 |
Absence of a general association between ABCB1 genetic variants and response to antiepileptic drugs in epilepsy patients.
Topics: Adolescent; Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Casse | 2010 |
Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.
Topics: Adolescent; Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Case-Control Studi | 2010 |
Phenytoin induced vitamin D deficiency presenting as proximal muscle weakness.
Topics: Child; Epilepsy; Female; Gait; Humans; Hyperparathyroidism, Secondary; Muscle Weakness; Phenytoin; V | 2010 |
Age and comedications influence levetiracetam pharmacokinetics in children.
Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; | 2010 |
Treatment of epilepsy in children with sodium dilantin.
Topics: Child; Epilepsy; Humans; Phenytoin; Sodium | 1946 |
Influence of CYP2C9 genetic polymorphism and undernourishment on plasma-free phenytoin concentrations in epileptic patients.
Topics: Adult; Alleles; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Epilepsy; F | 2010 |
An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges.
Topics: Action Potentials; Animals; Anticonvulsants; Cell Survival; Epilepsy; Ethosuximide; Glutamic Acid; H | 2011 |
A sensitive and selective HPLC method for estimation of lamotrigine in human plasma and saliva: application to plasma-saliva correlation in epileptic patients.
Topics: Anticonvulsants; Calibration; Chromatography, High Pressure Liquid; Epilepsy; Humans; Indicators and | 2010 |
Excretion of the principal urinary metabolites of phenytoin and absolute oral bioavailability determined by use of a stable isotope in patients with epilepsy.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Biological Availability; Chromatography, High Press | 2011 |
Suicidal risk and suicide attempts in people treated with antiepileptic drugs for epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Comorbidity; Depressive Disorder; Electroencephalography; | 2011 |
A candidate gene study of antiepileptic drug tolerability and efficacy identifies an association of CYP2C9 variants with phenytoin toxicity.
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Epilepsy; Female; Genetic A | 2011 |
[Resistance to vecuronium induced muscle relaxation in a patient with mental retardation receiving phenytoin for chronic anticonvulsant therapy].
Topics: Adult; Anesthesia, General; Drug Interactions; Drug Resistance; Epilepsy; Female; Humans; Intellectu | 2011 |
SCN1A splice variants exhibit divergent sensitivity to commonly used antiepileptic drugs.
Topics: Alternative Splicing; Anticonvulsants; Epilepsy; Humans; Lamotrigine; NAV1.1 Voltage-Gated Sodium Ch | 2011 |
Early postnatal exposure of rats to lamotrigine, but not phenytoin, reduces seizure threshold in adulthood.
Topics: Aging; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Female; Lamotrigine; Male; Phenyt | 2011 |
[Ophthalmoplegia produced by phenytoin].
Topics: Anticonvulsants; Epilepsy; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Ophthalmoplegia; P | 2009 |
Prophylactic anticonvulsants after subarachnoid hemorrhage.
Topics: Anticonvulsants; Epilepsy; Humans; Incidence; Levetiracetam; Phenytoin; Piracetam; Subarachnoid Hemo | 2011 |
Comparison of short-duration levetiracetam with extended-course phenytoin for seizure prophylaxis after subarachnoid hemorrhage.
Topics: Adult; Aged; Anticonvulsants; Databases, Factual; Delayed-Action Preparations; Disease-Free Survival | 2011 |
Association of antiepileptic drugs, vitamin D, and calcium supplementation with bone fracture occurrence in epilepsy patients.
Topics: Age Factors; Anticonvulsants; Calcium; Cohort Studies; Dietary Supplements; Epilepsy; Female; Fractu | 2011 |
[Development of rapid genotyping methods for single nucleotide polymorphisms of cytochrome P450 2C9 (CYP2C9) and cytochrome P450 2C19 (CYP2C19) and their clinical application in pediatric patients with epilepsy].
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Child, Preschool; Cytochrome P-450 CYP2C19; Cytochro | 2011 |
Pharmacogenetics: reality or fiction? Or are we there yet?
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Epilepsy; Female; Humans; M | 2011 |
CYP2C9 polymorphism in patients with epilepsy: genotypic frequency analyzes and phenytoin adverse reactions correlation.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Ep | 2011 |
[A case of toxicity caused by drug interaction between capecitabine and phenytoin in patient with colorectal cancer].
Topics: Adult; Anticonvulsants; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycy | 2011 |
Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Curcumin; Disease Models, Animal; Drug Interactions; Drug T | 2011 |
Clinical and pharmacy utilization outcomes with brand to generic antiepileptic switches in patients with epilepsy.
Topics: Anticonvulsants; Drug Substitution; Drugs, Generic; Emergency Service, Hospital; Epilepsy; Female; H | 2011 |
Normal vitamin D and low free estradiol levels in women on enzyme-inducing antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Bone Density; Carbamazepine; Epilepsy; Estradiol; Female; Humans | 2011 |
Vinpocetine inhibits glutamate release induced by the convulsive agent 4-aminopyridine more potently than several antiepileptic drugs.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Calcium; Carbamazepine; Drug Interactions; Epilepsy; Fruc | 2011 |
Capecitabine-phenytoin interaction is dose dependent with an unexpected time course.
Topics: Aged; Anticonvulsants; Antineoplastic Agents; Breast Neoplasms; Capecitabine; Deoxycytidine; Dose-Re | 2011 |
[Epilepsy in elderly].
Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies, | 2011 |
Phenytoin intoxication induced by Mandrax (methaqualone).
Topics: Anticonvulsants; Cerebellar Diseases; Diphenhydramine; Drug Combinations; Epilepsy; Humans; Male; Me | 2012 |
Correlation between serum and salivary phenytoin concentrations in Thai epileptic children.
Topics: Anticonvulsants; Asian People; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; | 2011 |
Effects of long-term antiepileptic drug monotherapy on vascular risk factors and atherosclerosis.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Atherosclerosis; Blood Glucose; Carbamazepine; Carotid Art | 2012 |
Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro.
Topics: Action Potentials; Animals; Anticonvulsants; Brain Injuries; Cell Death; Epilepsy; Excitatory Amino | 2012 |
Conversion from enzyme-inducing antiepileptic drugs to topiramate: effects on lipids and C-reactive protein.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; C-Reactive Protein; Carbamazepine; Epilepsy; Female | 2012 |
Genetic polymorphism of NAT2 metabolizing enzymes on phenytoin pharmacokinetics in Indian epileptic patients developing toxicity.
Topics: Adolescent; Adult; Arylamine N-Acetyltransferase; Epilepsy; Female; Gene Frequency; Humans; India; M | 2012 |
Clinical decision support of therapeutic drug monitoring of phenytoin: measured versus adjusted phenytoin plasma concentrations.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Chi-Square Distribution; Child; Child, | 2012 |
Thyroid hormones may contribute to vascular risk factors and atherosclerosis.
Topics: Anticonvulsants; Atherosclerosis; Carbamazepine; Carotid Artery, Common; Epilepsy; Female; Humans; M | 2012 |
Characterization of glucose homeostasis and lipid profile in adult, seizure-free, epileptic patients in Asian population.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Asian People; Blood Glucose; Cholesterol, LDL; Cross-Secti | 2012 |
Assessing adherence-based quality measures in epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cohort Studies; Epilepsy; Female; Follow-Up | 2012 |
Seizure management at Auckland City Hospital Emergency Department between July and December 2009: time for a change?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Disease Management; Emer | 2012 |
The effect of combination therapy on the plasma concentrations of traditional antiepileptics: a retrospective study.
Topics: Adolescent; Adult; Age Factors; Aged; Analysis of Variance; Anticonvulsants; Carbamazepine; Drug Int | 2012 |
A rat model for LGI1-related epilepsies.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Brain; Carbamazepine; Cells, Cultured; Chlorocebus ae | 2012 |
Functional genetic polymorphisms from phase-II drug metabolizing enzymes.
Topics: Arylamine N-Acetyltransferase; Epilepsy; Female; Humans; Male; Phenytoin; Polymorphism, Genetic | 2012 |
Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding C | 2013 |
B-vitamin deficiency in patients treated with antiepileptic drugs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans | 2012 |
Concentrations of stiripentol in children and adults with epilepsy: the influence of dose, age, and comedication.
Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Child; Child, Preschool; Dioxolanes; Dose-Response | 2012 |
Generalised stunting of roots in an epileptic child: is long-term phenytoin therapy the cause?
Topics: Adolescent; Anticonvulsants; Calcinosis; Diagnosis, Differential; Epilepsy; Female; Follow-Up Studie | 2012 |
DRESS syndrome.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Diagnosis, Differential; Drug Hypersensitivity Sy | 2012 |
Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore.
Topics: Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Cost-Benefit Analysis; Decision Making | 2012 |
Effects of polymorphisms in six candidate genes on phenytoin maintenance therapy in Han Chinese patients.
Topics: Adult; Alleles; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; ATP Binding Cassette T | 2012 |
A novel microextraction by packed sorbent-gas chromatography procedure for the simultaneous analysis of antiepileptic drugs in human plasma and urine.
Topics: Alprazolam; Anticonvulsants; Carbamazepine; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; | 2012 |
Asymmetric dimethylarginine may contribute to vascular risk factors in patients receiving antiepileptic drug treatment.
Topics: Anticonvulsants; Atherosclerosis; Carbamazepine; Carotid Artery, Common; Epilepsy; Female; Humans; M | 2012 |
Comparative stroke risk of antiepileptic drugs in patients with epilepsy.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male | 2013 |
Overexpression of multidrug resistance-associated protein 2 in the brain of pentylenetetrazole-kindled rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Chromatography, Liquid; Coloring Agents; Conv | 2012 |
Role of CYP2C9 polymorphism in phenytoin-related metabolic abnormalities and subclinical atherosclerosis in young adult epileptic patients.
Topics: Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Atherosclerosis; Cross-Sectional Studies; Cyt | 2013 |
How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)?
Topics: Anticonvulsants; Carbamazepine; Drug Discovery; Epilepsy; Ethosuximide; History, 20th Century; Human | 2012 |
Association of apolipoprotein E ε4 allele with cognitive impairment in patients with epilepsy and interaction with phenytoin monotherapy.
Topics: Adult; Anticonvulsants; Apolipoprotein E4; Case-Control Studies; Cholesterol; Cognition Disorders; E | 2013 |
The association between BsmI polymorphism and bone mineral density in young patients with epilepsy who are taking phenytoin.
Topics: 25-Hydroxyvitamin D 2; Absorptiometry, Photon; Adolescent; Adult; Anticonvulsants; Bone Density; Cal | 2013 |
The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy.
Topics: Adolescent; Adult; Aged; Alleles; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Atrophy; Cerebella | 2013 |
Effect of prenatal exposure to anticonvulsant drugs on dermal ridge patterns of fingers.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Dermatogly | 2002 |
Relationship between changes in drug score, D-glucaric acid excretion, and gamma-glutamyltransferase and beta-glucuronidase serum activities during anticonvulsant treatment.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Enzyme Induction; Epilepsy; | 2002 |
Chondrodysplasia punctata (CDP) with features of the tibia-metacarpal type and maternal phenytoin treatment during pregnancy.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Chondrodysplasia Punctata; Craniofacial Abnormalit | 2002 |
Adverse effects of phenytoin given for late-onset seizures in adults with Down syndrome.
Topics: Adult; Age of Onset; Aged; Anticonvulsants; Down Syndrome; Epilepsy; Female; Humans; Male; Middle Ag | 2002 |
Phenytoin toxicity as a result of 5-fluorouracil administration.
Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Drug Interactions; Epilepsy; Female; Fluorouracil; | 2002 |
Neurotoxic damage of granule cells in the dentate gyrus and the cerebellum and cognitive deficit following neonatal administration of phenytoin in mice.
Topics: Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Body Weight; Cerebellum; Cognition Disorders; | 2002 |
Incidence of phenytoin induced gingival overgrowth in epileptic children: a six month evaluation.
Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Gingival Hyperplasia; Humans; Incidence; Phenytoin | 2002 |
Administration of phenytoin and cytomegalovirus infection in the terminal ileum.
Topics: Aged; Anticonvulsants; Cytomegalovirus Infections; Diagnosis, Differential; Epilepsy; Female; Humans | 2002 |
Reversible panhypogammaglobulinemia associated with phenytoin treatment.
Topics: Adult; Agammaglobulinemia; Anticonvulsants; Epilepsy; Female; Follow-Up Studies; Headache; Humans; I | 2002 |
Truncus arteriosus in fetal hydantoin syndrome - a new association?
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Epilepsy; Fatal Outcom | 2003 |
Variability of total phenytoin serum concentrations within elderly nursing home residents.
Topics: Age Distribution; Aged; Aged, 80 and over; Body Weight; Dosage Forms; Drug Administration Routes; Ep | 2003 |
Evaluation of therapeutic drug monitoring of antiepileptic drugs.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Rela | 2003 |
Serum phenytoin concentration and IgG antibody titre to periodontal bacteria in patients with phenytoin-induced gingival overgrowth.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aggregatibacter actinomycetemcomitans; Antibodies, Ba | 2001 |
[Epileptic Münchausen syndrome by idiosyncratic of effect antiepileptic drugs].
Topics: Adult; Anticonvulsants; Diazepam; Electroencephalography; Epilepsy; Female; Headache; Humans; Muncha | 2003 |
Phenytoin-diazepam interaction.
Topics: Adult; Anticonvulsants; Diazepam; Drug Interactions; Epilepsy; Humans; Male; Phenytoin | 2003 |
Cerebellar volume and long-term use of phenytoin.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Cerebellum; Child; Child, Preschool; Dose-Response Relatio | 2003 |
Adverse events associated with intravenous phenytoin in children: a prospective study.
Topics: Adolescent; Anticonvulsants; Arrhythmia, Sinus; Child; Child, Preschool; Epilepsy; Extravasation of | 2003 |
Use of biperiden hydrochloride in a child with severe dyskinesia induced by phenytoin.
Topics: Anticonvulsants; Biperiden; Child, Preschool; Dyskinesia, Drug-Induced; Electroencephalography; Epil | 2003 |
Vigabatrin-induced decrease in serum phenytoin concentration does not involve a change in phenytoin bioavailability.
Topics: Adolescent; Adult; Anticonvulsants; Biological Availability; Drug Combinations; Drug Interactions; E | 1993 |
[Experiences with comital and comital-L].
Topics: Barbiturates; Drug Combinations; Epilepsy; Hydantoins; Mephobarbital; Phenobarbital; Phenytoin | 1951 |
Nuvarone (3-methyl-5, phenylhydantoin) in the treatment of epilepsy.
Topics: Epilepsy; Hydantoins; Phenytoin | 1953 |
Diphenylhydantoin, adrenal function and epilepsy.
Topics: Adrenal Cortex; Epilepsy; Hydantoins; Phenytoin | 1953 |
[Clinical experiences with diphenylhydantoins in the treatment of epilepsy, with special reference to lepitoin].
Topics: Epilepsy; Hydantoins; Phenytoin | 1953 |
[Significance of the attack point of diphenylhydantoin, phenobarbital and the acylureas for our comprehension of the physiopathological mechanism of epilepsy].
Topics: Animals; Barbiturates; Behavior, Animal; Comprehension; Epilepsy; Humans; Hydantoins; Phenobarbital; | 1953 |
[Effects of phenobarbital, acylureas and diphenylhydantoin on coma during electric epileptic crisis in guinea pig. II..].
Topics: Anticonvulsants; Barbiturates; Coma; Electricity; Epilepsy; Guinea Pigs; Phenobarbital; Phenytoin; S | 1953 |
[Further study on paradental changes caused by diphenylhydantoin sodium].
Topics: Disease; Epilepsy; Hydantoins; Hyperplasia; Hypertrophy; Periodontal Diseases; Periodontium; Phenyto | 1953 |
Megaloblastic anaemia due to phenytoin sodium.
Topics: Anemia; Anemia, Megaloblastic; Epilepsy; Humans; Hydantoins; Phenytoin | 1954 |
Megaloblastic anaemia due to phenytoin sodium.
Topics: Anemia; Anemia, Megaloblastic; Epilepsy; Humans; Hydantoins; Phenytoin | 1954 |
[Adrenocortical function, diphenylhydantoin and epilepsy].
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Epilepsy; Humans; Hydantoins; Phenytoin | 1954 |
Hypertrichosis occurring in association with dilantin therapy.
Topics: Child; Epilepsy; Hair; Hair Diseases; Humans; Hydantoins; Hypertrichosis; Infant; Phenytoin | 1955 |
Speculations regarding the nature of gingival hyperplasia due to diphenylhydantoin-sodium.
Topics: Disease; Epilepsy; Gingiva; Gingival Diseases; Gingival Hyperplasia; Hydantoins; Hyperplasia; Hypert | 1956 |
Treatment of epilepsy with diphenylhydantoin sodium (dilantin sodium).
Topics: Epilepsy; Humans; Hydantoins; Phenytoin; Sodium | 1956 |
Treatment of epilepsy with diphenylhydantoin sodium (dilantin sodium).
Topics: Epilepsy; Humans; Hydantoins; Phenytoin; Sodium | 1956 |
Treatment of epilepsy with diphenylhydantoin sodium (dilantin sodium).
Topics: Epilepsy; Humans; Hydantoins; Phenytoin; Sodium | 1956 |
Treatment of epilepsy with diphenylhydantoin sodium (dilantin sodium).
Topics: Epilepsy; Humans; Hydantoins; Phenytoin; Sodium | 1956 |
Megaloblastic anaemia occurring during treatment of epilepsy with phenytoin sodium, primidone and phenobarbitone.
Topics: Anemia; Anemia, Megaloblastic; Anticonvulsants; Epilepsy; Humans; Hydantoins; Phenobarbital; Phenyto | 1957 |
Use of parenteral diphenylhydantoin (dilantin) sodium in control of status epilepticus.
Topics: Epilepsy; Hydantoins; Ions; Phenytoin; Sodium; Sodium, Dietary; Status Epilepticus | 1958 |
Diphenylhydantoin and phenobarbital in serum in patients with epilepsy.
Topics: Epilepsy; Humans; Hydantoins; Phenobarbital; Phenytoin | 1958 |
[Dilantin therapy of epilepsy in children].
Topics: Child; Epilepsy; Humans; Hydantoins; Infant; Phenytoin | 1957 |
Dilantin toxicity. A clinical and electroence-phalographic study.
Topics: Epilepsy; Hydantoins; Phenytoin | 1961 |
[Status of epilepsy in children: clinical experience with sodium diphenylhydantoin by parenteral route].
Topics: Child; Epilepsy; Hydantoins; Infant; Phenytoin; Sodium | 1961 |
[Experimentation with a new antiepileptic drug derived from phenytoin: 5,5-diphenyltetrahydroimidazole-4-one (glior)].
Topics: Anticonvulsants; Epilepsy; Imidazoles; Phenytoin; Research Design | 1959 |
Aspects of the pharmacology of phenytoin (dilantin) and phenobarbital relevant to their dosage in the treatment of epilepsy.
Topics: Epilepsy; Humans; Hydantoins; Phenobarbital; Phenytoin | 1960 |
[Use of parenteral dilantin sodium in control of neurosurgical convulsive seizure].
Topics: Epilepsy; Hydantoins; Neurosurgery; Neurosurgical Procedures; Phenytoin; Seizures; Sodium | 1962 |
Differential effects of antiepileptics on hippocampal and pallidal afterdischarges in cats.
Topics: Animals; Anticonvulsants; Cats; Epilepsy; Globus Pallidus; Hippocampus; Phenobarbital; Phenytoin | 1962 |
[Now and then: development of drug treatment of epilepsy since A. Hauptmann].
Topics: Anticonvulsants; Epilepsy; Humans; Phenobarbital; Phenytoin; Primidone; Pyrrolidinones | 1962 |
Treatment of epilepsy.
Topics: Acetazolamide; Anticonvulsants; Automatism; Child; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clon | 1963 |
A fatal case of erythema multiforme exudativum (Stevens-Johnson's syndrome) following therapy with dilantin.
Topics: Drug Eruptions; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenytoin; Seizures; Stevens-Johnson Syndr | 1962 |
Fatal liver necrosis and diphenylhydantoin sensitivity.
Topics: Drug Hypersensitivity; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Liver Diseases; Phenytoin; Seizures | 1962 |
ANTIEPILEPTIC DRUGS.
Topics: Acetazolamide; Amphetamine; Amphetamines; Anticonvulsants; Barbiturates; Bromides; Epilepsy; Ethosux | 1963 |
ANTI-EPILEPTIC DRUGS AND THE FOETUS.
Topics: Barbiturates; Epilepsy; Female; Fetal Diseases; Fetus; Phenobarbital; Phenytoin; Pregnancy; Pregnanc | 1963 |
MEGALOBLASTIC ANAEMIA ASSOCIATED WITH ANTICONVULSANT THERAPY.
Topics: Amobarbital; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Barbiturates; Epilepsy; Fol | 1963 |
BEHAVIOR DISORDERS OF INTEREST TO DERMATOLOGISTS.
Topics: Adolescent; Behavior; Bites and Stings; Child; Child Behavior Disorders; Dermatology; Epilepsy; Fing | 1963 |
THORAZINE AS AN EPILEPTOGENIC AGENT.
Topics: Chlorpromazine; Epilepsy; Humans; Pharmacology; Phenytoin; Primidone; Schizophrenia | 1963 |
[A CURED CASE OF PANMYELOPATHY DUE TO HYDANTOIN THERAPY].
Topics: Adrenal Cortex Hormones; Anemia; Anemia, Myelophthisic; Anticonvulsants; Blood Transfusion; Epilepsy | 1963 |
THE INFANT WITH EPILEPSY.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Birth Injuries; Classific | 1963 |
[ETIOLOGY AND THERAPY OF STATUS EPILEPTICUS].
Topics: Abortion, Septic; Anticonvulsants; Birth Injuries; Brain Injuries; Brain Neoplasms; Chloral Hydrate; | 1963 |
DOSAGE OF PHENYTOIN AND PHENOBARBITAL IN CHILDREN.
Topics: Blood Chemical Analysis; Child; Epilepsy; Fever; Humans; Phenobarbital; Phenytoin; Seizures | 1963 |
DELAYED TOXICITY AND SERUM CONCENTRATIONS OF PHENYTOIN.
Topics: Blood Chemical Analysis; Consciousness; Depression; Depressive Disorder; Epilepsy; Humans; Neurologi | 1963 |
[QUANTITATIVE DETERMINATIONS OF DIPHENYLHYDANTOIN IN PATIENTS WITH EPILEPSY].
Topics: Blood Chemical Analysis; Epilepsy; Phenytoin | 1963 |
SUBNORMAL SERUM FOLATE AND MACROCYTOSIS ASSOCIATED WITH ANTICONVULSANT DRUG THERAPY.
Topics: Anemia; Anemia, Macrocytic; Anticonvulsants; Biological Assay; Blood Chemical Analysis; Enterococcus | 1964 |
[GENESIS, CLASSIFICATION AND THERAPY OF LOSS OF CONSCIOUSNESS].
Topics: Caffeine; Child; Classification; Electroencephalography; Epilepsy; Epilepsy, Absence; Humans; Oxyphe | 1963 |
CONVULSIONS.
Topics: Black People; Diagnosis, Differential; Epilepsy; Humans; Intellectual Disability; Phenobarbital; Phe | 1964 |
HYPERPLASIA GINGIVAE DIPHENYLHYDANTOINEA. A CLINICAL, HISTOLOGICAL, AND BIOCHEMICAL STUDY.
Topics: Adolescent; Child; Collagen; Dentition; Epilepsy; Gingiva; Gingival Hyperplasia; Glycosaminoglycans; | 1963 |
MEDICAL TREATMENT OF EPILEPSIES IN CHILDHOOD. A LONG-TERM SURVEY OF 801 PATIENTS.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child; Electroenc | 1963 |
SOME INHIBITORY EFFECTS OF ATTENTIVE FACTORS ON EXPERIMENTAL EPILEPSY.
Topics: Acetylcholine; Aminobutyrates; Carboxy-Lyases; Cats; Electric Stimulation; Electroencephalography; E | 1963 |
GINGIVAL HYPERPLASIA AND DILANTIN CONTENT OF SALIVA: A PILOT STUDY.
Topics: Adolescent; Chemistry Techniques, Analytical; Epilepsy; Gingiva; Gingival Hyperplasia; Humans; Hyper | 1964 |
[INCREASE OF INTELLECTUAL EFFICIENCY BY ANTICONVULSIVE THERAPY IN LATENT DISPOSITION TO CONVULSIONS].
Topics: Anticonvulsants; Child; Electroencephalography; Epilepsy; Humans; Intelligence Tests; Phenytoin; Sei | 1963 |
SOME OBSERVATIONS ON THE ELECTROGRAPHIC CORRELATES OF THE DECEREBRATE ATTACK.
Topics: Child; Coma; Decerebrate State; Electroencephalography; Epilepsy; Humans; Hypoxia, Brain; Infusions, | 1964 |
[PSEUDOCOLLAGENOSIS OR MALIGNANT PSEUDOLYMPHOMA?INJURIOUS EFFECT OF A HYDANTOIN DERIVATIVE].
Topics: Adrenal Cortex Hormones; Biopsy; Diagnosis, Differential; Epilepsy; Erythema; Fever; Humans; Hydanto | 1964 |
PSYCHOMOTOR VARIANT TYPE OF SEIZURE DISCHARGE.
Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, T | 1963 |
CONVULSIVE EQUIVALENT SYNDROME OF CHILDHOOD.
Topics: Acetazolamide; Adolescent; Anticonvulsants; Autonomic Nervous System Diseases; Child; Chlorpromazine | 1964 |
[FEBRILE CONVULSIONS IN CHILDREN. PROGNOSTIC STUDIES AND AN ATTEMPTED EVALUATION OF THE EFFECTS OF PROLONGED PROPHYLACTIC ANTIEPILEPSY TREATMENT. A PRELIMINARY REPORT].
Topics: Child; Denmark; Epilepsy; Exanthema Subitum; Fever; Humans; Infant; Phenytoin; Prognosis; Respirator | 1964 |
[SERUM PHENYTOIN CONCENTRATION IN EPILEPTIC OUTPATIENTS].
Topics: Adolescent; Blood Chemical Analysis; Child; Denmark; Epilepsy; Geriatrics; Humans; Outpatients; Phen | 1964 |
[TREATMENT OF EPILEPSY IN ADULTS. A BRIEF SURVEY OF THE CLINICAL PROBLEMS].
Topics: Acetazolamide; Anticonvulsants; Blood Chemical Analysis; Chloral Hydrate; Data Collection; Electroen | 1964 |
CONVULSIONS IN INFANCY AND CHILDHOOD.
Topics: Anticonvulsants; Child; Electroencephalography; Encephalitis; Epilepsy; Epilepsy, Absence; Epilepsy, | 1963 |
DIPHENYLHYDANTOIN AND PHENOBARBITAL. SERUM LEVELS IN CHILDREN.
Topics: Adolescent; Blood; Child; Drug Therapy; Epilepsy; Humans; Infant; Pharmacology; Phenobarbital; Pheny | 1964 |
SEIZURES INDUCED BY MOVEMENT: A FORM OF REFLEX EPILEPSY.
Topics: Adolescent; Athetosis; Cerebral Angiography; Diagnosis, Differential; Electroencephalography; Epilep | 1964 |
[MEGALOBLASTIC ANEMIA PRODUCED BY ANTICONVULSANTS].
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Argentina; Barbiturates; Blood C | 1963 |
[OBSERVATION ON TWO CASES OF EPILEPSIA CURSIVA].
Topics: Adolescent; Atrophy; Barbiturates; Cerebral Cortex; Chlordiazepoxide; Dichlorphenamide; Electroencep | 1964 |
SERUM DIPHENYLHYDANTOIN (PHENYTOIN) IN AMBULANT PATIENTS WITH EPILEPSY.
Topics: Adolescent; Biomedical Research; Blood; Child; Drug Therapy; Epilepsy; Epilepsy, Temporal Lobe; Epil | 1964 |
REPORT ON THE ANTI-EPILEPTIC ACTION OF TEGRETOL.
Topics: Acetazolamide; Adolescent; Anticonvulsants; Biomedical Research; Carbamazepine; Child; Chlordiazepox | 1964 |
ZARONTIN (ETHOSUXIMIDE) IN THE TREATMENT OF PETIT MAL AND RELATED DISORDERS.
Topics: Adolescent; Anticonvulsants; Biomedical Research; Child; Denmark; Drug Therapy; Epilepsy; Epilepsy, | 1964 |
[ANTI-EPILEPTIC ACTIVITY OF TRINURIDE].
Topics: Anticonvulsants; Epilepsy; Pharmacology; Phenobarbital; Phenytoin; Toxicology | 1964 |
EFFECTS OF ANTICONVULSIVE MEDICATION ON VESTIBULAR FUNCTION. AN ELECTRONYSTAGMOGRAPHIC STUDY.
Topics: Electronystagmography; Epilepsy; Humans; Nystagmus, Pathologic; Pharmacology; Phenobarbital; Phenyto | 1964 |
[DEMONSTRATION OF THE "TRANSFER FACTOR" IN HYDANTOIN ALLERGY PRESENTING AS SUBACUTE LUPUS ERYTHEMATOSUS IN GENUINE EPILEPSY].
Topics: Anticonvulsants; Drug Eruptions; Drug Hypersensitivity; Epilepsy; Lupus Erythematosus, Systemic; Phe | 1964 |
[REHABILITATION OF THE EPILEPTIC. CLINICAL EXPERIENCE WITH A POTENTIALIZED ANTICONVULSANT].
Topics: Anticonvulsants; Barbiturates; Epilepsy; Humans; Mephobarbital; Phenobarbital; Phenytoin | 1964 |
DRUG-INDUCED IN-VITRO STIMULATION OF PERIPHERAL LYMPHOCYTES.
Topics: Antigen-Antibody Reactions; Child; Dermatitis; Drug Hypersensitivity; Epilepsy; Fever; Hepatomegaly; | 1964 |
EXPERIMENTAL SUBCORTICAL EPILEPTIFORM FOCUS.
Topics: Aluminum; Amygdala; Cats; Electroencephalography; Epilepsy; Hippocampus; Pharmacology; Phenobarbital | 1964 |
HINTS ON SEIZURE MANAGEMENT.
Topics: Anticonvulsants; Drug Therapy; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Hu | 1964 |
IATROGENIC MEGALOBLASTIC ANAEMIA WITH NEUROLOGICAL COMPLICATIONS.
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Brain Diseases; Cysticercosis; Drug Therapy; Epil | 1964 |
[3 CASES OF TELEVISION EPILEPSY].
Topics: Child; Drug Therapy; Electroencephalography; Epilepsy; Epilepsy, Reflex; Humans; Phenobarbital; Phen | 1964 |
NOTE ON THE INTERACTIONS OF AMPHETAMINE WITH ANTICONVULSANT DRUGS.
Topics: Amphetamine; Amphetamines; Animals; Anticonvulsants; Electricity; Electroshock; Epilepsy; Epilepsy, | 1964 |
ANESTHETIC MANAGEMENT OF THE PARTURIENT WITH INTRACRANIAL TUMOR.
Topics: Anesthesia; Anesthesia, Endotracheal; Anesthesia, Spinal; Anesthetics; Angiography; Brain Neoplasms; | 1964 |
[POSSIBILITIES OF COMBINED ANTICONVULSANT TREATMENT IN CHRONIC SEIZURES].
Topics: Adolescent; Anticonvulsants; Child; Drug Therapy; Epilepsy; Humans; Infant; Infant, Newborn; Phenoba | 1964 |
MEGALOBLASTIC ANEMIA AND NEUROLOGIC DISTURBANCES COMBINED WITH FOLIC ACID DEFICIENCY. OBSERVATIONS ON AN EPILEPTIC PATIENT TREATED WITH ANTICONVULSANTS.
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Avitaminosis; Barbiturates; Brai | 1964 |
EFFECT OF DIPHENYLHYDANTOIN ON NEUROMUSCULAR SYNAPSE.
Topics: Electromyography; Epilepsy; Humans; Infant; Muscular Diseases; Neural Conduction; Neuromuscular Junc | 1964 |
CONVULSIONS.
Topics: Epilepsy; Humans; Infant; Paraldehyde; Phenytoin; Seizures; Toxicology | 1964 |
TREATMENT OF HEADACHES IN CHILDREN.
Topics: Adolescent; Child; Drug Therapy; Epilepsy; Headache; Humans; Methysergide; Migraine Disorders; Pheno | 1964 |
TEMPORAL LOBE EPILEPSY: A CLINICAL STUDY OF 47 CASES.
Topics: Adolescent; Biomedical Research; Birth Injuries; Depression; Depressive Disorder; Diagnosis, Differe | 1964 |
CHILD CARE IN GENERAL PRACTICE. CONVULSIONS IN INFANCY AND CHILDHOOD. II.
Topics: Acetazolamide; Anticonvulsants; Bromides; Child; Child Care; Chloral Hydrate; Diagnosis; Drug Therap | 1965 |
DIPHENYLHYDANOIN-INDUCED HYPERSENSITIVITY REACTION.
Topics: Blood Cell Count; Child; Drug Eruptions; Drug Hypersensitivity; Drug Therapy; Epilepsy; Epilepsy, Te | 1965 |
SODIUM DIPHENYLHYDANTOIN REACTION WITH EVIDENCE OF CIRCULATING ANTIBODIES.
Topics: Antibodies; Anticonvulsants; Drug Hypersensitivity; Drug Therapy; Epilepsy; Epilepsy, Tonic-Clonic; | 1965 |
[TREATMENT OF EPILEPSY WITH 3-ETHOXYCARBO-5,5-DIPHENYLHYDANTOIN (P-6127), A NEW ANTICONVULSANT].
Topics: Anticonvulsants; Ataxia; Blood Chemical Analysis; Drug Therapy; Electroencephalography; Epilepsy; Ep | 1964 |
PROBENECID (BENEMID) INTOXICATION WITH STATUS EPILEPTICUS.
Topics: Coma; Drug Therapy; Epilepsy; Gout; Phenobarbital; Phenytoin; Poisoning; Probenecid; Status Epilepti | 1965 |
SERUM PHENYTOIN DETERMINATIONS IN EPILEPTICS.
Topics: Anticonvulsants; Blood Chemical Analysis; Child; Drug Therapy; Electroencephalography; Epilepsy; Hum | 1964 |
NEUROLOGICAL PROBLEMS IN ADOLESCENCE WITH PARTICULAR ATTENTION TO SEIZURES.
Topics: Adolescent; Attention; Child; Child Behavior Disorders; Drug Therapy; Electroencephalography; Epilep | 1965 |
MEGALOBLASTIC ANAEMIA ASSOCIATED WITH ANTICONVULSANT DRUGS: STUDIES ON A CASE WITH FOUR RELAPSES.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Drug Therapy; Electrophoresis; Epilepsy; | 1965 |
DIPHENYLHYDANTOIN ACTIVATED SEIZURES.
Topics: Drug Therapy; Electroencephalography; Epilepsy; Phenytoin; Seizures; Toxicology | 1965 |
NEUROLOGICAL SEQUELAE FOLLOWING DILANTIN OVERDOSE IN A PATIENT AND IN EXPERIMENTAL ANIMALS.
Topics: Adolescent; Ataxia; Biomedical Research; Cats; Chlordiazepoxide; Drug Therapy; Epilepsy; Humans; Neu | 1965 |
THE PERIODICALLY RECURRING FOCAL DISCHARGE.
Topics: Animals; Cerebrovascular Disorders; Child; Drug Therapy; Electrocardiography; Electroencephalography | 1965 |
SYNDROME OF GINGIVAL HYPERPLASIA, HIRSUTISM, AND CONVULSIONS; DILANTIN INTOXICATION WITHOUT DILANTIN.
Topics: Ataxia; Brain Diseases; Child; Chlorpheniramine; Diagnosis, Differential; Diencephalon; Drug Therapy | 1965 |
GINGIVAL HYPERPLASIA IN DILANTIN THERAPY FOR EPILEPTICS.
Topics: Drug Therapy; Epilepsy; Gingival Hyperplasia; Humans; Phenytoin; Toxicology | 1965 |
[Leukemia in an epileptic treated with gardenal and dihydan; recovery; fatal mysoline poisoning with fatty degeneration of the liver and acute epithelial nephritis].
Topics: Anticonvulsants; Barbiturates; Epilepsy; Humans; Hydantoins; Leukemia; Leukocytosis; Liver Diseases; | 1955 |
Megaloblastic anaemia due to phenytoin sodium.
Topics: Anemia; Anemia, Megaloblastic; Epilepsy; Hydantoins; Phenytoin; Tracheophyta | 1955 |
Recent experiences with parenteral dilantin.
Topics: Epilepsy; Phenytoin | 1959 |
Diffusion tensor MRI and fiber tractography of cerebellar atrophy in phenytoin users.
Topics: Adult; Afferent Pathways; Anisotropy; Anticonvulsants; Atrophy; Cerebellum; Diagnosis, Differential; | 2003 |
Influence of coadministered antiepileptic drugs on serum zonisamide concentrations in epileptic patients: quantitative analysis based on suitable transforming factor.
Topics: Administration, Oral; Adolescent; Adult; Aging; Anticonvulsants; Biological Availability; Body Surfa | 2003 |
CYP2C polymorphisms, phenytoin metabolism and gingival overgrowth in epileptic subjects.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; C | 2004 |
Validated high performance liquid chromatographic method for simultaneous determination of phenytoin, phenobarbital and carbamazepine in human serum.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Humans; Indicators a | 2003 |
Spotlight on oxcarbazepine in epilepsy.
Topics: Adolescent; Anticonvulsants; Area Under Curve; Carbamazepine; Child; Child, Preschool; Clinical Tria | 2004 |
Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism?
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Epilepsy; Female; Gest | 2003 |
Oral tegafur/folinic acid chemotherapy decreases phenytoin efficacy.
Topics: Administration, Oral; Anticonvulsants; Antimetabolites, Antineoplastic; Carcinoma; Drug Interactions | 2004 |
What comes after dilantin?
Topics: Epilepsy; Humans; Hydantoins; Phenytoin; Psychotherapy | 1950 |
Comparative results in seizure control using phenobarbital, dilantin, and mesantoin.
Topics: Barbital; Epilepsy; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Seizures | 1950 |
Dilantin hyperplasia.
Topics: Epilepsy; Gingiva; Humans; Hyperplasia; Phenytoin | 1951 |
[Therapy of genuine epilepsy with sodium diphenylhydantoinate].
Topics: Anions; Epilepsy; Humans; Ions; Phenytoin; Sodium; Sodium, Dietary | 1951 |
The mode of action of sodium diphenylhydantoinate (dilantin) in epilepsy.
Topics: Epilepsy; Hydantoins; Phenytoin | 1951 |
Potentially inappropriate antiepileptic drugs for elderly patients with epilepsy.
Topics: Acetates; Aged; Amines; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Epilepsy; Female; Ga | 2004 |
Acute visual dysfunction following phenytoin-induced toxicity.
Topics: Adult; Anticonvulsants; Color Perception; Epilepsy; Evoked Potentials, Visual; Humans; Male; Optic N | 2003 |
Interaction between anticonvulsants and human placental carnitine transporter.
Topics: Acetates; Amines; Aminoisobutyric Acids; Anticonvulsants; Carnitine; Carrier Proteins; Culture Techn | 2004 |
Cost of epilepsy in patients attending a secondary-level hospital in India.
Topics: Anticonvulsants; Carbamazepine; Efficiency, Organizational; Epilepsy; Hospital Costs; Hospitalizatio | 2004 |
The effect of long-term antiepileptic treatment on serum cholesterol (TC, HDL, LDL) and triglyceride levels in adult epileptic patients on monotherapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cholesterol; Cholesterol, HDL; Cholesterol, | 2004 |
Modulation of antiepileptic effect of phenytoin and carbamazepine by melatonin in mice.
Topics: Animals; Anticonvulsants; Area Under Curve; Carbamazepine; Chromatography, High Pressure Liquid; Dis | 2004 |
Clinical policy: Critical issues in the evaluation and management of adult patients presenting to the emergency department with seizures.
Topics: Adult; Anticonvulsants; Electroencephalography; Emergency Service, Hospital; Epilepsy; Humans; Pheny | 2004 |
Phenytoin-induced gingival overgrowth in un-cooperated epilepsy patients.
Topics: Adult; Anticonvulsants; Epilepsy; Gingival Overgrowth; Humans; Male; Oral Hygiene; Patient Complianc | 2004 |
The role of seizures in reversible posterior leukoencephalopathy.
Topics: Anticonvulsants; Electroencephalography; Epilepsy; Female; Functional Laterality; Humans; Magnetic R | 2004 |
The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats.
Topics: Animals; Anticonvulsants; Cilastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Elec | 2004 |
Activation of serum aminotransferases by pyridoxal-5' -phosphate in epileptic patients treated with anticonvulsant drugs.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Carbamazepine; Drug Therapy, Combination; | 2004 |
Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models.
Topics: Action Potentials; Animals; Anticonvulsants; Brain; Cobalt; Disease Models, Animal; Drug Combination | 2004 |
Dosage recommendation of phenytoin for patients with epilepsy with different CYP2C9/CYP2C19 polymorphisms.
Topics: Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CYP2C19; Cytoc | 2004 |
The use of 3,-methyl,5,phenylhydantoin (AC 114) in the treatment of epilepsy (a preliminary report).
Topics: Epilepsy; Hydantoins; Phenytoin | 1950 |
The outcome of initiation of antiepileptic drug monotherapy in primary care: a UK database survey.
Topics: Aged; Anticonvulsants; Carbamazepine; Child, Preschool; Clinical Competence; Epilepsy; Family Practi | 2004 |
Significance of MDR1 and multiple drug resistance in refractory human epileptic brain.
Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Anticonvulsants; Astrocytes; ATP Binding Cassette Tr | 2004 |
Assessment of the epilepsy treatment gap in two cities of south-east of Brazil.
Topics: Adult; Anticonvulsants; Brazil; Carbamazepine; Epilepsy; Health Services Accessibility; Health Servi | 2004 |
Longer term outcome of children born to mothers with epilepsy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Fema | 2004 |
Lower phenytoin serum levels in persons switched from brand to generic phenytoin.
Topics: Adult; Anticonvulsants; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Drugs, Generic; Epi | 2004 |
Phenytoin use in elderly nursing home residents.
Topics: Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Cross-Sectional Studies; Data Collection; Epi | 2003 |
Hypogeusia as an adverse reaction of phenytoin.
Topics: Ageusia; Anticonvulsants; Epilepsy; Humans; Male; Middle Aged; Phenytoin | 2004 |
[Association between genetic polymorphisms of CYP2C19 and CYP2C9 and phenytoin serum concentration].
Topics: Adolescent; Adult; Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Child; Child, Preschool; Cytochrome | 2004 |
Isoforms of serum gamma-glutamyltransferase in epileptic patients treated with enzyme-inducing anticonvulsant drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; gamma-Glutamyltransferase; Humans; Isoenzym | 2004 |
Influence of coadministered antiepileptic drugs on serum phenobarbital concentrations in epileptic patients: quantitative analysis based on a suitable transforming factor.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Chil | 2004 |
[Influence of psychotropic drugs on thrombocytes aggregation in patients with epilepsy].
Topics: Adolescent; Adult; Barbiturates; Carbamazepine; Epilepsy; Humans; In Vitro Techniques; Lamotrigine; | 2004 |
Mechanisms of edema after gamma knife surgery for meningiomas. Report of two cases.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Anticonvulsants; Brain Edema; Dexamethasone; Epilepsy; | 2005 |
Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Bone and Bones; Bone Remodeling; Carbamazepine; Epilepsy; Female | 2005 |
Phenytoin intoxication in critically ill patients.
Topics: Epilepsy; Face; Female; Humans; Liver Failure, Acute; Middle Aged; Phenytoin | 2005 |
Letter to the neurology editor.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden; Epilepsy; Humans; Myocardial Infarction | 2005 |
Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin.
Topics: Adolescent; Adult; Aged; Alleles; Amino Acid Sequence; Anticonvulsants; Aryl Hydrocarbon Hydroxylase | 2005 |
Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics.
Topics: Anticonvulsants; Carbamazepine; Causality; Epilepsy; Germany; Humans; Incidence; Inpatients; Lamotri | 2005 |
A fragile site at 10q23 (FRA10A) in a phenytoin-exposed fetus: a case report and review of the literature.
Topics: Adult; Amniocentesis; Anticonvulsants; Cells, Cultured; Chromosome Deletion; Chromosome Fragile Site | 2005 |
Lower phenytoin serum levels in persons switched from brand to generic phenytoin.
Topics: Anticonvulsants; Drug and Narcotic Control; Drugs, Generic; Epilepsy; Humans; Legislation, Pharmacy; | 2005 |
Lower phenytoin serum levels in persons switched from brand to generic phenytoin.
Topics: Anticonvulsants; Conflict of Interest; Drug Industry; Drugs, Generic; Epilepsy; Humans; Phenytoin; T | 2005 |
Gene variants affect response to antiepileptic drugs.
Topics: Alternative Splicing; Anticonvulsants; Carbamazepine; Cytochrome P-450 Enzyme System; Drug Resistanc | 2005 |
An epilepsy mutation in the beta1 subunit of the voltage-gated sodium channel results in reduced channel sensitivity to phenytoin.
Topics: Animals; CHO Cells; Cricetinae; Epilepsy; Humans; Mutation; NAV1.3 Voltage-Gated Sodium Channel; Ner | 2005 |
Seizures following reduction in phenytoin level after orally administered folic acid.
Topics: Administration, Oral; Anemia, Macrocytic; Anticonvulsants; Dose-Response Relationship, Drug; Down-Re | 2005 |
Fit for a fracture.
Topics: Anticonvulsants; Epilepsy; Ergocalciferols; Female; Femoral Neck Fractures; Follow-Up Studies; Fract | 2005 |
Lower phenytoin serum levels in persons switched from brand to generic phenytoin.
Topics: Anticonvulsants; Clinical Trials as Topic; Conflict of Interest; Disclosure; Drug Industry; Epilepsy | 2005 |
Lower phenytoin serum levels in persons switched from brand to generic phenytoin.
Topics: Anticonvulsants; Bone Marrow Transplantation; Busulfan; Epilepsy; Humans; Phenytoin; Seizures; Thera | 2005 |
Lower phenytoin serum levels in persons switched from brand to generic phenytoin.
Topics: Anticonvulsants; Clinical Protocols; Clinical Trials as Topic; Epilepsy; Humans; Phenytoin; Reproduc | 2005 |
Lower phenytoin serum levels in persons switched from brand to generic phenytoin.
Topics: Anticonvulsants; Clinical Protocols; Clinical Trials as Topic; Drug Administration Routes; Epilepsy; | 2005 |
Norfluoxetine and fluoxetine have similar anticonvulsant and Ca2+ channel blocking potencies.
Topics: Animals; Anticonvulsants; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signa | 2005 |
RLIP76, a non-ABC transporter, and drug resistance in epilepsy.
Topics: Adolescent; Adult; Animals; ATP-Binding Cassette Transporters; Child; Child, Preschool; Drug Resista | 2005 |
Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Casse | 2005 |
Treatment delay and the risk of prolonged status epilepticus.
Topics: Administration, Rectal; Anticonvulsants; Benzodiazepines; Child, Preschool; Clinical Protocols; Dise | 2005 |
Improvement of oligoasthenozoospermia in epileptic patients on switching anti-epilepsy medication from sodium valproate to phenytoin.
Topics: Adult; Anticonvulsants; Epilepsy; Follow-Up Studies; Humans; Male; Oligospermia; Phenytoin; Sperm Co | 2005 |
[Anticonvulsive pharmacotherapy may aggravate epilepsy course].
Topics: Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy; | 2005 |
Benign angiopathy of the central nervous system associated with phenytoin intoxication.
Topics: Adult; Anticonvulsants; Cerebral Angiography; Epilepsy; Humans; Male; Paresis; Phenytoin; Vascular D | 2006 |
Introduction to the International Geriatric Epilepsy Symposium (IGES).
Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Brain Diseases; Epilepsy; Geriatrics; Homes for the | 2006 |
Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, vitamin B12, folic acid and vitamin B6.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Epilepsy; Female; Folic Aci | 2006 |
Epileptic seizures superimposed on catatonic stupor.
Topics: Aged; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Catatonia; Combined Modality Therapy; | 2006 |
Physical growth and psychomotor development of infants exposed to antiepileptic drugs in utero.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Growth; Humans; Infant; Maternal Age; Motor Activity; Pari | 2006 |
[Odinophagia and cutaneous lesions in patient with cerebral metastases].
Topics: Aged; Anticonvulsants; Back; Brain Neoplasms; Cyclosporine; Dermis; Epilepsy; Fatal Outcome; Humans; | 2006 |
[Rapid analysis of antiepileptic drugs in human plasma by micellar electrokinetic capillary chromatography].
Topics: Anticonvulsants; Buffers; Carbamazepine; Chromatography, Micellar Electrokinetic Capillary; Clonazep | 2006 |
Effect of piperine on the steady-state pharmacokinetics of phenytoin in patients with epilepsy.
Topics: Adult; Alkaloids; Anticonvulsants; Area Under Curve; Benzodioxoles; Biological Availability; Dose-Re | 2006 |
Seizure disorder in a professional American football player.
Topics: Adult; Anticonvulsants; Dietary Supplements; Electroencephalography; Epilepsy; Football; Humans; Hyp | 2006 |
Phenytoin-induced DRESS with cross-reactivity to carbamazepine in a 10-year-old Indian child.
Topics: Anticonvulsants; Blood Chemical Analysis; Carbamazepine; Child; Drug Eruptions; Eosinophilia; Epilep | 2006 |
Antiepileptic TDM pattern at a tertiary care hospital in India.
Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; India; Pharmacology, Clinical; Ph | 2006 |
Epilepsy in the elderly.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Anticonvulsants; Comorbidity; Drug Costs; Drug Int | 2006 |
Polymorphic variants of the multidrug resistance gene Mdr1a and response to antiepileptic drug treatment in the kindling model of epilepsy.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transp | 2006 |
Toxic epidermal necrolysis in a mother and fetus.
Topics: Adolescent; Anticonvulsants; Biopsy; Epilepsy; Female; Fetal Death; Fetus; Humans; Infectious Diseas | 2006 |
Free phenytoin concentration measurement in brain extracellular fluid: a pilot study.
Topics: Adolescent; Adult; Anticonvulsants; Brain Chemistry; Brain Injuries; Epilepsy; Extracellular Fluid; | 2006 |
Is oral azithromycin effective for the treatment of phenytoin-induced gingival overgrowth in epileptic patients?
Topics: Administration, Oral; Anti-Bacterial Agents; Anticonvulsants; Azithromycin; Drug Interactions; Epile | 2007 |
Epilepsy, parkinsonism, and neuroleptic malignant syndrome in a child.
Topics: Anticonvulsants; Antiparkinson Agents; Aspartic Acid; Basal Ganglia; Benzothiazoles; Carbamazepine; | 2006 |
Epilepsy and antiepileptic drug use in elderly people as risk factors for dementia.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Anticonvulsants; Cohort Studies; Epilepsy; Female | 2007 |
Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, M | 2007 |
Cerebral atrophy and skull thickening due to chronic phenytoin therapy.
Topics: Adult; Anticonvulsants; Atrophy; Cerebellar Diseases; Diagnosis, Differential; Epilepsy; Female; Hum | 2007 |
Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese.
Topics: Adult; Algorithms; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CY | 2007 |
Evaluation of therapeutic drug level monitoring of phenobarbital, phenytoin and carbamazepine in Iranian epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Monitoring; Drug Therapy, Combination; Epile | 2007 |
Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs.
Topics: Anticonvulsants; Astrocytes; Blood-Brain Barrier; Brain; Cells, Cultured; Coculture Techniques; Diaz | 2007 |
Macroprolactinomas and epilepsy.
Topics: Adult; Anticonvulsants; Dopamine Agonists; Drug Therapy, Combination; Epilepsy; Epilepsy, Temporal L | 2007 |
Intestinal expression of cytochrome P450 enzymes and ABC transporters and carbamazepine and phenytoin disposition.
Topics: Adult; Aged; Anticonvulsants; ATP-Binding Cassette Transporters; Carbamazepine; Cytochrome P-450 Enz | 2007 |
Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri | 2007 |
Antiepileptic drugs prevent changes induced by pilocarpine model of epilepsy in brain ecto-nucleotidases.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphatases; Adenosine Triphosphate; A | 2007 |
Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy.
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Trans | 2007 |
Diminished response of CA1 neurons to antiepileptic drugs in chronic epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamazepine; Chronic Disease; Dentate Gyrus; Disease | 2007 |
The natural history and treatment of epilepsy in a murine model of tuberous sclerosis.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalograp | 2007 |
Rash from antiepileptic drugs: influence by gender, age, and learning disability.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Comorbidity; Drug Eruptions; Epileps | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Therapeutic drug monitoring and clinical outcomes in epileptic Egyptian patients: a gene polymorphism perspective study.
Topics: Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transpor | 2007 |
Phenytoin but not valproate directly affected in vitro trophoblast differentiation.
Topics: Anticonvulsants; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Epilepsy; | 2008 |
Contributions of CYP2C9/CYP2C19 genotypes and drug interaction to the phenytoin treatment in the Korean epileptic patients in the clinical setting.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; Bayes Theorem | 2007 |
Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Acetamides; Algorithms; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease | 2007 |
[Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy].
Topics: Adenocarcinoma; Aged; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Combined Modality Therapy; | 2007 |
[Drug-induced hypersensitivity due to phenytoin].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Hypersensitivity; Epilepsy; Humans; Male; | 2007 |
A painful gum.
Topics: Anticonvulsants; Epilepsy; Family Practice; Gingiva; Gingival Hyperplasia; Humans; Hygiene; Male; Mi | 2007 |
Preliminary explorations of the role of mitochondrial proteins in refractory epilepsy: some findings from comparative proteomics.
Topics: Animals; Anticonvulsants; Databases, Factual; Disease Models, Animal; Electric Stimulation; Electrop | 2007 |
[Influence of repeated seizures and large dosage anti-epileptic drug on phosphorylated cAMP response element binding protein in rat's hippocampus and effect of Caoguo Zhimu Decoction].
Topics: Animals; Cognition Disorders; Cyclic AMP Response Element-Binding Protein; Drugs, Chinese Herbal; Ep | 2007 |
Undetectable phenytoin serum levels by an automated particle-enhanced turbidimetric inhibition immunoassay in a patient with monoclonal IgM lambda.
Topics: Aged; Anticonvulsants; Automation; Epilepsy; Female; Humans; Immunoassay; Immunoglobulin M; Paraprot | 2008 |
Temporal pattern of oxcarbazepine and phenytoin withdrawal seizures during epilepsy monitoring.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Electroencephalography; Epi | 2008 |
Phenytoin toxicity: an easily missed cause of cerebellar syndrome.
Topics: Aged; Anticonvulsants; Cerebellar Diseases; Epilepsy; Humans; Male; Middle Aged; Phenytoin | 2008 |
Contraindications to phenytoin in emergency department patients with seizures.
Topics: Anticonvulsants; Contraindications; Emergency Service, Hospital; Epilepsy; Female; Humans; Levetirac | 2009 |
Simultaneous toxicities in a child on multiple anticonvulsants.
Topics: Anticonvulsants; Bone Marrow; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Child, P | 2008 |
Bone health.
Topics: Adult; Anticonvulsants; Bone Diseases, Metabolic; Epilepsy; Female; Humans; Patient Dropouts; Phenyt | 2008 |
Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy.
Topics: Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Biomarkers; Bone Density; Bone Diseases, M | 2008 |
Association between SCN1A polymorphism and carbamazepine-resistant epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Female; Genotype; | 2008 |
Generalized tonic-clonic seizures after acute oxcarbazepine withdrawal.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged; Oxca | 2008 |
Post-hemiplegic epilepsy in the elderly.
Topics: Aged; Epilepsy; Female; Hemiplegia; Humans; Intracranial Embolism and Thrombosis; Male; Middle Aged; | 1967 |
Epilepsy--facts and fancy.
Topics: Electroencephalography; Epilepsy; Humans; Phenobarbital; Phenytoin | 1967 |
The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine.
Topics: Acetazolamide; Adult; Aged; Alcoholism; Amitriptyline; Chlordiazepoxide; Chlorpromazine; Chromatogra | 1967 |
Movement epilepsy. Two case reports with photographs of the typical movements.
Topics: Adolescent; Electroencephalography; Epilepsy; Humans; Male; Movement; Movement Disorders; Phenytoin | 1967 |
The epidemiology of drug-induced systemic lupus erythematosus.
Topics: Adolescent; Adult; Aged; Child; Epilepsy; Female; Heart Diseases; Humans; Hydralazine; Hypertension; | 1967 |
Serum creatine phosphokinase activity in epilepsy. Clinical and experimental studies.
Topics: Animals; Child; Creatine Kinase; Electroshock; Epilepsy; Female; Gallamine Triethiodide; Humans; Mal | 1967 |
Epilepsy induced by cardiac pacemaker.
Topics: Aged; Amobarbital; Digoxin; Epilepsy; Female; Humans; Nerve Crush; Pacemaker, Artificial; Phenobarbi | 1967 |
[Motor activity after diphenylhydantoin intoxication].
Topics: Adult; Cerebellum; Electroencephalography; Epilepsy; Humans; Male; Motor Activity; Movement Disorder | 1967 |
Phenytoin (Dilantin) intoxication.
Topics: Adolescent; Adult; Aged; Anorexia Nervosa; Ataxia; Child; Epilepsy; Female; Humans; Male; Mental Dis | 1967 |
Anticonvulsant therapy and its possible consequences on peripheral nervous system: a neurographic study.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Neural Conduction; Peripheral Nerves; Peripheral N | 1984 |
Anticonvulsant drug therapy in human pregnancy: effects on serum concentrations of vitamin D metabolites in maternal and cord blood.
Topics: 24,25-Dihydroxyvitamin D 3; Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Calcifediol; C | 1984 |
Phenytoin toxicity secondary to cimetidine administration.
Topics: Aged; Cimetidine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Peptic Ulc | 1984 |
The effects of diphenylhydantoin on the relationship between high-density lipoprotein cholesterol and several biochemical assays.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Australia; Cholesterol; Epilepsy; Fasting; Female; ga | 1980 |
Psychiatric implications of anticonvulsant drugs.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Dose-Response Relationship, Dr | 1980 |
[Effect of barbexaclone treatment on thyroid function in epileptic children and juveniles (author's transl)].
Topics: Adolescent; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phenyt | 1980 |
Transfer from multiple to single antiepileptic drug therapy.
Topics: Adult; Anticonvulsants; Drug Administration Schedule; Epilepsy; Female; Humans; Male; Middle Aged; P | 1981 |
Effects of phenytoin on serum gamma-glutamyl transpeptidase activity.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Dose-Response Relationship, Drug; Enz | 1981 |
Once-a-day drug regimen for psychiatric patients.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Anxiety; Depressive Disorder; Drug Administratio | 1981 |
Choice of anticonvulsants in epilepsy.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool | 1981 |
The influence of antiepileptic drugs on the electroencephalogram: a review of controlled clinical studies.
Topics: Anti-Anxiety Agents; Anticonvulsants; Brain; Carbamazepine; Clonazepam; Electroencephalography; Epil | 1982 |
[Rise in gamma-GT during anticonvulsive therapy].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combinatio | 1982 |
Pharmacokinetics of antiepileptic drugs.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool | 1983 |
Pharmacodynamic factors in the occurrence of psychiatric symptoms among patients with epilepsy.
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Epilepsy; Folic Acid; Humans; Kinetics; Mental Disorde | 1983 |
A rapid gas liquid chromatography method for simultaneous determination of various anticonvulsants.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Drug Therapy, Combination; Epilepsy; Humans; Ph | 1980 |
Quantitative analysis of training, sleep EEG and clinical response to EEG operant conditioning in epileptics.
Topics: Adolescent; Adult; Biofeedback, Psychology; Conditioning, Operant; Electroencephalography; Electromy | 1980 |
The reversibility of phenytoin-induced IgA deficiency.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Child; Epilepsy; Female; Humans; IgA Deficiency; Immu | 1981 |
Plasma concentrations of valproate during maintenance therapy in epileptic children.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Epilepsy, A | 1982 |
Plasma arginine vasopressin concentrations in epileptics under monotherapy.
Topics: Adult; Anticonvulsants; Arginine Vasopressin; Carbamazepine; Epilepsy; Humans; Phenytoin; Primidone; | 1983 |
Diabetes mellitus in a mongoloid child with chronic diphenylhydantoin therapy.
Topics: Child; Diabetes Mellitus, Type 1; Down Syndrome; Epilepsy; Female; Humans; Phenytoin; Risk | 1982 |
[Hodgkin's disease in an epileptic treated with hydantoins].
Topics: Adult; Epilepsy; Hodgkin Disease; Humans; Male; Phenytoin | 1983 |
Acne and anticonvulsants.
Topics: Acne Vulgaris; Adolescent; Adult; Aged; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged | 1983 |
Serum anticonvulsant concentrations and the risk of drug induced skin eruptions.
Topics: Carbamazepine; Craniotomy; Drug Eruptions; Epilepsy; Humans; Phenytoin; Postoperative Complications | 1984 |
Epilepsy and the management of dental disease.
Topics: Dental Care for Disabled; Epilepsy; Gingival Hyperplasia; Humans; Phenytoin | 1984 |
Side effects of antiepileptic drugs: a peripheral neuropathy due to diphenylhydantoin (DPH) intoxication.
Topics: Adolescent; Adult; Aged; Electromyography; Epilepsy; Female; Humans; Male; Middle Aged; Peripheral N | 1980 |
Peripheral neuropathy in epileptic patients.
Topics: Epilepsy; H-Reflex; Humans; Neural Conduction; Peripheral Nervous System Diseases; Peroneal Nerve; P | 1981 |
Lack of effect of phenytoin on functions related to Na+,K+-ATPase activity of the intact erythrocytes of epileptic patients.
Topics: Digoxin; Epilepsy; Erythrocyte Membrane; Erythrocytes; Humans; Phenytoin; Sodium-Potassium-Exchangin | 1981 |
[Survival period of patients with gliomata or glioblastomata under anti-convulsive therapy (author's transl)].
Topics: Adult; Brain Neoplasms; Epilepsy; Female; Glioblastoma; Glioma; Humans; Male; Phenytoin; Prognosis | 1981 |
Peripheral neuropathy in children on long-term phenytoin therapy.
Topics: Adolescent; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Long-Term Care; Male; | 1981 |
Phenytoin prolongs far-field somatosensory and auditory evoked potential interpeak latencies.
Topics: Acoustic Stimulation; Auditory Pathways; Dose-Response Relationship, Drug; Electric Stimulation; Epi | 1982 |
Central excitatory properties of delta 9-tetrahydrocannabinol and its metabolites in iron-induced epileptic rats.
Topics: Animals; Cannabidiol; Central Nervous System; Dronabinol; Electrophysiology; Epilepsy; Iron; Male; P | 1982 |
Peripheral neuropathy in epileptics.
Topics: Animals; Epilepsy; Humans; Peripheral Nervous System Diseases; Phenytoin; Rats | 1982 |
Cytomegalovirus antibodies in epileptics receiving diphenylhydantoin.
Topics: Adolescent; Adult; Antibodies, Viral; Antibody Formation; Cytomegalovirus; Cytomegalovirus Infection | 1982 |
Lack of interaction between ranitidine and phenytoin.
Topics: Drug Interactions; Epilepsy; Furans; Humans; Phenytoin; Ranitidine | 1983 |
Peripheral nerve damage in epileptic patients treated with phenytoin.
Topics: Adolescent; Adult; Epilepsy; Female; Humans; Male; Middle Aged; Peripheral Nervous System Diseases; | 1983 |
The treatable epilepsies.
Topics: Adrenocorticotropic Hormone; Child; Epilepsy; Humans; Phenytoin; Spasms, Infantile; Valproic Acid | 1983 |
[Side-effects of phenytoin and carbamazepine on electrophysiologic functions of the peripheral and central nervous system].
Topics: Brain; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalog | 1983 |
Variability of phenytoin protein binding in epileptic patients.
Topics: Epilepsy; Humans; Immunoenzyme Techniques; Phenytoin; Protein Binding; Retrospective Studies; Ultraf | 1983 |
Landmark article Sept 17, 1938: Sodium diphenyl hydantoinate in the treatment of convulsive disorders. By H. Houston Merritt and Tracy J. Putnam.
Topics: Adolescent; Adult; Epilepsy; History, 20th Century; Humans; Middle Aged; Phenytoin; United States | 1984 |
Landmark perspective: Introduction of sodium diphenyl hydantoinate.
Topics: Epilepsy; History, 20th Century; Humans; Phenytoin; United States | 1984 |
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo | 1983 |
Serum folate concentrations during pregnancy in women with epilepsy: relation to antiepileptic drug concentrations, number of seizures, and fetal outcome.
Topics: Carbamazepine; Congenital Abnormalities; Epilepsy; Female; Fetal Death; Folic Acid; Humans; Phenobar | 1983 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Humans; Phenobarbital; Phenytoin; Statu | 1983 |
Treatment of the nonconvulsive epilepsies.
Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Humans; Phenobarbi | 1983 |
[Myasthenic syndrome following long-term diphenylhydantoin therapy].
Topics: Adult; Electromyography; Epilepsy; Female; Humans; Long-Term Care; Myasthenia Gravis; Phenytoin | 1983 |
[Role of the brain stem in the modification of epileptic activity in sleep states].
Topics: Adolescent; Adult; Aged; Brain Stem; Child; Child, Preschool; Electroencephalography; Epilepsy; Evok | 1983 |
[Pharmacotherapy of epilepsy--current problems and controversies].
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, | 1983 |
Should we routinely measure free plasma phenytoin concentration?
Topics: Adolescent; Adult; Aged; Blood Proteins; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Pro | 1984 |
Unnecessary polypharmacy in patients with frequent seizures.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Drug Therapy, Combination; Epi | 1984 |
Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy.
Topics: Abnormalities, Drug-Induced; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Endocrine Syst | 1983 |
Hepatic toxicity of antiepileptic drugs: a review.
Topics: Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Energy Metabolism; Epilepsy; | 1983 |
Pituitary responsiveness to gonadotrophin-releasing and thyrotrophin-releasing hormones in epileptic patients receiving carbamazepine or phenytoin.
Topics: Adult; Carbamazepine; Epilepsy; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone | 1984 |
Lowering effect of diphenylhydantoin on serum free thyroxine and thyroxine binding globulin (TBG).
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Phenytoin; | 1984 |
Antiepileptic drugs and psychiatric disorders: mechanism involved in manifestation of psychic symptoms of high blood level of antiepileptics.
Topics: Adult; Anticonvulsants; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Humans; Male; Mental D | 1983 |
Effect of anticonvulsant drugs on thalamo-cortical and hippocampo-cortical self-sustained after-discharges in the rat.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Electric Stimulation; Electroencephalograp | 1984 |
Summing up of the success so far gained through choice of drugs or combinations of drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Cognition Disorders; Drug Therapy, Combination; Epilepsy; Hum | 1984 |
Effect of valproate on free plasma phenytoin concentrations.
Topics: Adult; Binding, Competitive; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Protein Binding | 1984 |
[The incidence of postoperative epilepsy and prophylactic anticonvulsants in patients with intracranial aneurysm].
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; In | 1984 |
Clinical value of determination of serum concentration of antiepileptics.
Topics: Adolescent; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; In | 1984 |
Nonsedative regimens in the treatment of epilepsy.
Topics: Carbamazepine; Epilepsy; Ethosuximide; Humans; Phenytoin; Seizures; Valproic Acid | 1983 |
A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients.
Topics: Anticonvulsants; Antipyrine; Carbamazepine; Enzyme Induction; Epilepsy; Female; Glucaric Acid; Half- | 1984 |
[Plasma levels of antiepileptic agents in the treatment of epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Interac | 1984 |
Electrically elicited seizures from the inferior colliculus: a potential site for the genesis of epilepsy?
Topics: Animals; Chlordiazepoxide; Electric Stimulation; Electrophysiology; Epilepsy; Inferior Colliculi; Ma | 1984 |
Anticonvulsant effects on the memory performance of epileptics.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Intelligence; Memory; Memory Di | 1984 |
Anticonvulsants, folic acid and memory dysfunction in epileptics.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Erythrocytes; Folic Acid; Humans; Memor | 1984 |
[Mono- or polytherapy of epilepsy?].
Topics: Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Long-Term Care; Phenytoin | 1984 |
Epilepsy in children.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diagnosis, Differential; Electroencephalogr | 1984 |
Fetal exposure to anticonvulsant drugs. Detailed pathological study of a case.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Adult; Anticonvulsants; Brain; Cardiomegaly; Epilepsy; E | 1980 |
Systemic effects of oral use of chlorhexidine gel in multihandicapped epileptic children.
Topics: Adolescent; Adult; Child; Child, Preschool; Chlorhexidine; Dental Care for Disabled; Double-Blind Me | 1981 |
Clinical application of the Mullen and Foster method for individualizing phenytoin dosage.
Topics: Aged; Epilepsy; Female; Humans; Kinetics; Male; Middle Aged; Phenytoin | 1984 |
Maprotiline hydrochloride associated with a clinical state of catatonic stupor and epileptic encephalogram.
Topics: Anthracenes; Catatonia; Depressive Disorder; Diazepam; Drug Therapy, Combination; Electroencephalogr | 1984 |
Medically resistant epilepsy: low levels of drugs in the brain or pharmacological inefficacy?
Topics: Adolescent; Adult; Brain; Drug Resistance; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin | 1984 |
Bioavailability and pharmacokinetics of phenytoin during pregnancy.
Topics: Aging; Biological Availability; Epilepsy; Female; Humans; Kinetics; Phenytoin; Pregnancy; Pregnancy | 1984 |
Functional palatal incompetence in the fetal anticonvulsant syndrome.
Topics: Abnormalities, Drug-Induced; Child, Preschool; Epilepsy; Female; Humans; Male; Maternal-Fetal Exchan | 1984 |
Acquired craniofacial features associated with chronic phenytoin therapy.
Topics: Adult; Chronic Disease; Epilepsy; Face; Female; Humans; Male; Maxillofacial Development; Phenytoin; | 1984 |
Excretion of organic acids associated with biotin deficiency in chronic anticonvulsant therapy.
Topics: Adult; Anticonvulsants; Biotin; Carbamazepine; Carboxy-Lyases; Carboxylic Acids; Epilepsy; Female; H | 1984 |
Determination of plasma phenytoin by capillary gas chromatography with nitrogen-phosphorus detection and with selective ion monitoring.
Topics: Adult; Alkylation; Chemical Phenomena; Chemistry; Chromatography, Gas; Epilepsy; Female; Gas Chromat | 1984 |
Changes induced in human liver by long-term anticonvulsant therapy. Functional and ultrastructural data.
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Endoplasm | 1984 |
Bribery.
Topics: Adolescent; Epilepsy; Family Health; Gingival Hypertrophy; Humans; Lymph Nodes; Lymphatic Diseases; | 1984 |
Teratogenicity of anticonvulsant drugs. III: Radiographic hand analysis of children exposed in utero to diphenylhydantoin.
Topics: Epilepsy; Female; Hand; Hand Deformities, Congenital; Humans; Male; Phenytoin; Pregnancy; Pregnancy | 1984 |
Genetic background: the elusive component in the fetal hydantoin syndrome.
Topics: Epilepsy; Female; Hand Deformities, Congenital; Head; Humans; Phenytoin; Pregnancy; Pregnancy Compli | 1984 |
[Epilepsy, anticonvulsants and pregnancy].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications | 1984 |
Differential effect of antiepileptic and non-antiepileptic drugs on the reticular formation.
Topics: Action Potentials; Animals; Anticonvulsants; Baclofen; Carbamazepine; Cats; Dose-Response Relationsh | 1984 |
Effect of folic acid supplementation on congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Folic Aci | 1984 |
Single dose pharmacokinetic study of clobazam in normal volunteers and epileptic patients.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbama | 1984 |
High-dose monotherapy in treatment of intractable seizures.
Topics: Adult; Carbamazepine; Epilepsy; Humans; Middle Aged; Phenytoin; Seizures | 1984 |
Therapeutic plasma levels of phenytoin, phenobarbital, and carbamazepine: individual variation in relation to seizure frequency and type.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenobar | 1984 |
Chromosomal studies of peripheral blood from epileptic patients treated with phenobarbital and/or diphenylhydantoin.
Topics: Adult; Animals; Chromosome Aberrations; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; M | 1984 |
The estimation of working capacity in epileptic patients.
Topics: Adolescent; Adult; Disability Evaluation; Epilepsy; Finland; Humans; Phenytoin; Prognosis; Rehabilit | 1983 |
Case of the month. Gingival enlargement.
Topics: Adolescent; Epilepsy; Gingival Hypertrophy; Humans; Male; Phenytoin | 1983 |
Medical exorcism--acute dilantin intoxication.
Topics: Cardiovascular Diseases; Epilepsy; Humans; Kinetics; Nystagmus, Pathologic; Phenytoin | 1984 |
Phenytoin induced gingival overgrowth in institutionalized epileptics.
Topics: Adolescent; Adult; Aged; Epilepsy; Female; Gingival Hyperplasia; Gingivitis; Humans; Institutionaliz | 1984 |
Rationalisation of therapy in severe epilepsy.
Topics: Adult; Anticonvulsants; Arousal; Atrophy; Cerebellum; Drug Administration Schedule; Drug Therapy, Co | 1983 |
Oral hygiene status of epileptic patients under treatment with diphenyl hydantoin.
Topics: Adolescent; Adult; Aged; Child; Epilepsy; Female; Gingival Hyperplasia; Humans; Male; Middle Aged; P | 1983 |
The influence of carbamazepine and phenytoin on memory and other aspects of cognitive function in new referrals with epilepsy.
Topics: Adolescent; Adult; Aged; Carbamazepine; Cognition Disorders; Decision Making; Epilepsy; Fixation, Oc | 1984 |
Dementia in epilepsy.
Topics: Adult; Anticonvulsants; Brain Injuries; Dementia; Epilepsy; Epilepsy, Temporal Lobe; Humans; Middle | 1984 |
Regression of gingival hyperplasia after cessation of phenytoin drug therapy--a case report.
Topics: Adult; Epilepsy; Gingival Hyperplasia; Humans; Male; Phenytoin; Remission, Spontaneous | 1984 |
Effects of phenobarbital, diphenylhydantoin and carbamazepine on thyroid function in epileptic children.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Epilepsy; Humans; Phenobarbital; Phenytoin; Thyr | 1984 |
Effects of phenytoin on man's immunity. Evaluation of changes in serum immunoglobulins, complement, and antinuclear antibody.
Topics: Adolescent; Adult; Aged; Antibodies, Antinuclear; Central Nervous System Diseases; Child; Child, Pre | 1983 |
Brain regional pharmacokinetics of 11C-labeled diphenylhydantoin: positron emission tomography in humans.
Topics: Adolescent; Adult; Brain; Carbon Radioisotopes; Epilepsy; Female; Humans; Kinetics; Male; Phenytoin; | 1983 |
The effect of prolonged phenytoin administration on non-collagenous components of gingival tissue.
Topics: Adult; Epilepsy; Gingiva; Hexosamines; Humans; Hyperplasia; Middle Aged; Phenytoin; Proteins; Uronic | 1983 |
Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports.
Topics: Adult; Drug Therapy, Combination; Epilepsy; Gynecomastia; Humans; Male; Phenobarbital; Phenytoin; Pr | 1983 |
Routine determination of hydroxyphenytoin in urine by high-performance liquid chromatography using an automatic column-switching technique.
Topics: Chromatography, High Pressure Liquid; Epilepsy; Humans; Phenytoin; Statistics as Topic | 1983 |
Acute effects of intravenous phenytoin on the frequency of inter-ictal spikes in man.
Topics: Adult; Electroencephalography; Epilepsy; Humans; Infusions, Parenteral; Phenytoin; Time Factors | 1983 |
Oxazepam pharmacokinetics in patients with epilepsy treated long-term with phenytoin alone or in combination with phenobarbitone.
Topics: Adult; Bilirubin; Dialysis; Drug Interactions; Epilepsy; Female; Humans; Kinetics; Male; Middle Aged | 1983 |
[Development of malignant lymphoma during anticonvulsant therapy].
Topics: Epilepsy; Gastrointestinal Neoplasms; Humans; Lung Neoplasms; Lymphoma; Male; Middle Aged; Phenytoin | 1983 |
[Phenytoin kinetics in toxic serum levels].
Topics: Adolescent; Adult; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Kinetics; Male | 1983 |
Gas-liquid chromatographic determination of propylene glycol in plasma and urine.
Topics: Butylene Glycols; Chromatography, Gas; Epilepsy; Flame Ionization; Humans; Phenytoin; Propylene Glyc | 1983 |
[Relations to the use of antiepileptics by the pregnant woman to the development of congenital abnormalities in her child].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Hydantoins; Infant, Newborn; | 1983 |
[Hydantoin poisoning: clinical aspects, laboratory parameters and EEG].
Topics: Adolescent; Adult; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Therapy, Combinat | 1983 |
A quantitative determination of anticonvulsant-induced bone demineralization by an improved X-ray densitometry technique.
Topics: Absorptiometry, Photon; Adolescent; Adult; Aged; Anticonvulsants; Bone and Bones; Carbamazepine; Dru | 1983 |
Reduction of polypharmacy for epilepsy in an institution for the retarded.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Huma | 1983 |
Salivary phenytoin levels in institutionalized epileptics.
Topics: Adolescent; Adult; Aged; Chromatography, Gas; Epilepsy; Humans; Institutionalization; Intellectual D | 1983 |
Presenile cataracts in hydantoin-treated epileptic patients.
Topics: Adult; Animals; Cataract; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Rats | 1983 |
Phenytoin and folic acid: individualized drug-drug interaction.
Topics: Drug Interactions; Epilepsy; Folic Acid; Humans; Male; Middle Aged; Phenytoin | 1983 |
Predicting phenytoin dosages using Bayesian feedback: a comparison with other methods.
Topics: Adult; Bayes Theorem; Epilepsy; Female; Humans; Kinetics; Male; Middle Aged; Models, Biological; Phe | 1983 |
Fluctuations in steady-state phenytoin concentrations as measured in saliva in children.
Topics: Capsules; Child; Child, Preschool; Epilepsy; Female; Humans; Kinetics; Male; Phenytoin; Saliva; Susp | 1983 |
A design for the prospective evaluation of the efficacy and toxicity of antiepileptic drugs in adults.
Topics: Adult; Aged; Anticonvulsants; Behavior; Carbamazepine; Clinical Trials as Topic; Double-Blind Method | 1983 |
Comparison of bioavailability for phenytoin products prepared by wet granulation in normal subjects and epileptic patients.
Topics: Adolescent; Adult; Biological Availability; Child; Child, Preschool; Epilepsy; Feces; Female; Humans | 1983 |
Effect of phenytoin and corticosteroids on seizures and lipid peroxidation in experimental posttraumatic epilepsy.
Topics: Animals; Brain Injuries; Chlorides; Electroencephalography; Epilepsy; Ferric Compounds; Lipid Peroxi | 1984 |
Variability of phenytoin protein binding in epilepsy.
Topics: Epilepsy; Humans; Phenytoin | 1984 |
Influence of bioavailability on the calculated Michaelis-Menten parameters of phenytoin in children.
Topics: Absorption; Adolescent; Biological Availability; Child; Child, Preschool; Dose-Response Relationship | 1984 |
Phenytoin preferentially suppresses epileptiform activity in the superficial cortical layers of the cat.
Topics: Animals; Cats; Cerebral Cortex; Electroencephalography; Epilepsy; Penicillins; Phenytoin | 1984 |
Serum concentrations and efficacy of phenytoin, phenobarbital, and primidone in canine epilepsy.
Topics: Animals; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Phenobarbital; Phenytoin; Primidon | 1984 |
[Initial therapeutic results in epileptic children with and without serum-controlled phenytoin treatment].
Topics: Child; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Humans; Phenytoin; Progno | 1984 |
[EEG findings and phenytoin concentration in the serum of children with epilepsy].
Topics: Child; Electroencephalography; Epilepsy; Female; Humans; Male; Phenytoin | 1984 |
Plasma concentrations of unbound phenytoin in the management of epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbon Radioisotopes; Child; Drug Therapy, Combination; Ep | 1984 |
Cerebellar atrophy following diphenylhydantoin intoxication.
Topics: Adolescent; Atrophy; Cerebellum; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Ph | 1984 |
Kinetics of intravenous phenytoin in children.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Infant; Injections, Intravenous; Kinetics; Ph | 1984 |
Urinary hydroxyphenytoin/creatinine ratios as an index of compliance in adult epileptic patients on phenytoin therapy.
Topics: Creatinine; Epilepsy; Female; Humans; Male; Models, Biological; Patient Compliance; Phenytoin | 1984 |
Use of plasma unbound drug concentrations in adjusting phenytoin doses.
Topics: Adolescent; Adult; Blood Proteins; Child; Child, Preschool; Epilepsy; Female; Humans; Kinetics; Male | 1984 |
Prospective neurometric studies during the beginning of carbamazepine and phenytoin therapy.
Topics: Action Potentials; Adolescent; Adult; Carbamazepine; Cerebral Cortex; Electroencephalography; Electr | 1984 |
Antiepileptic drug utilization in pediatric patients.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Infant; Infant, Newborn; Kin | 1984 |
[Anticonvulsive combined therapy (author's transl)].
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epileps | 1980 |
Sex hormone changes in male epileptics.
Topics: Adult; Epilepsy; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Humans; Luteinizing Hormone | 1980 |
[Differential treatment of epilepsy patients].
Topics: Anticonvulsants; Carbamazepine; Diagnosis, Differential; Drug Therapy, Combination; Epilepsy; Epilep | 1980 |
Variable in vivo binding of valproic acid in epilepsy patients being medicated with other anticonvulsants.
Topics: Binding, Competitive; Epilepsy; Humans; Phenytoin; Serum Albumin; Valproic Acid | 1980 |
Therapeutic alternatives in phenytoin-induced gingival hyperplasia. A case report and discussion.
Topics: Adolescent; Epilepsy; Female; Gingival Hyperplasia; Humans; Phenytoin; Primidone; Valproic Acid | 1980 |
Binding of drugs to human serum albumin. XIV. The theoretical basis for the interaction between phenytoin and valproate.
Topics: Adolescent; Binding, Competitive; Blood Proteins; Child; Epilepsy; Humans; Phenytoin; Protein Bindin | 1980 |
Interaction between phenytoin and valproate.
Topics: Blood Proteins; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Protein B | 1980 |
Pharmacokinetics of anticonvulsant drugs.
Topics: Anticonvulsants; Binding, Competitive; Brain; Carbamazepine; Drug Interactions; Drug Tolerance; Epil | 1980 |
Drug interactions in epilepsy.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Humans; Isoniazid; P | 1980 |
Impact of therapeutic audit on phenytoin prescribing.
Topics: Drug Administration Schedule; Epilepsy; Humans; Medical Audit; Phenytoin | 1981 |
Cimetidine interaction with phenytoin.
Topics: Adult; Cimetidine; Drug Interactions; Epilepsy; Guanidines; Humans; Middle Aged; Phenytoin | 1981 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Female; | 1981 |
[Daily fluctuations of plasma diphenylhydantoin in patients treated with diphenylhydantoin and sodium valproate].
Topics: Adult; Circadian Rhythm; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Valproic Acid | 1981 |
[Daily plasma fluctuations of diphenylhydantoin in patients treated with diphenylhydantoin and sodium valproate].
Topics: Adult; Epilepsy; Humans; Phenytoin; Time Factors; Valproic Acid | 1981 |
[Polytherapy and monotherapy in the treatment of patients with epilepsy].
Topics: Adult; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, | 1981 |
Recent advances in the treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Huma | 1980 |
[Spindles and spike waves in the sleep EEG of epileptic patients under administration of phenobarbital (PB) and phenytoin (DPH) (author's transl)].
Topics: Electroencephalography; Epilepsy; Evoked Potentials; Humans; Phenobarbital; Phenytoin; Sleep Stages | 1981 |
[EEG in phenytoin intoxication (author's transl)].
Topics: Adult; Central Nervous System Diseases; Cerebellar Ataxia; Dose-Response Relationship, Drug; Electro | 1981 |
Phenytoin-valproate interaction: importance of saliva monitoring in epilepsy.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Epil | 1982 |
Daily fluctuations of dipropylacetate (DPA) serum level in epileptic patients.
Topics: Adolescent; Adult; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle | 1980 |
Serial free and plasma valproic acid and phenytoin monitoring and drug interactions.
Topics: Adolescent; Adult; Circadian Rhythm; Drug Interactions; Epilepsy; Female; Humans; Male; Phenytoin; V | 1981 |
Plasma levels and pharmacokinetics of antipileptic drugs in children.
Topics: Adolescent; Age Factors; Anticonvulsants; Biological Availability; Biotransformation; Carbamazepine; | 1981 |
Epileptic seizures in the elderly: II. Diagnostic problems.
Topics: Aged; Brain; Cerebral Infarction; Confusion; Dementia; Diagnosis, Differential; Electroencephalograp | 1982 |
Diurnal oscillations in plasma protein binding of valproic acid.
Topics: Adolescent; Adult; Blood Proteins; Circadian Rhythm; Epilepsy; Fatty Acids, Nonesterified; Female; H | 1982 |
Stuporous episodes during treatment with sodium valproate: report of seven cases.
Topics: Anticonvulsants; Cognition Disorders; Consciousness Disorders; Electroencephalography; Epilepsy; Fem | 1982 |
Monitoring free valproic acid in epilepsy patients medicated with coanticonvulsants.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Phenytoin; Valpro | 1982 |
The effects of anticonvulsants on memory function in epileptic patients: preliminary findings.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Memory; Memory, Short-Term; Mental Recall; Phenyto | 1981 |
Phenytoin elimination after intoxication during long-term treatment.
Topics: Adolescent; Adult; Epilepsy; Female; Humans; Long-Term Care; Middle Aged; Phenytoin | 1982 |
Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy.
Topics: Adult; Anticonvulsants; Antipyrine; Delivery, Obstetric; Dose-Response Relationship, Drug; Epilepsy; | 1982 |
Early prognosis of epilepsy.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsies, Partial; Epilepsy; Female; Humans; Male; | 1982 |
Therapeutic concentration of antiepileptic drugs and the severity of epileptogenesis.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Isoxazoles; Phenytoin; Valproic Acid; Zonisamide | 1982 |
[A study on cerebrospinal fluid and saliva to serum concentration ratios of anticonvulsants--Phenytoin, Phenobarbital, Valproic Acid and Primidone in epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Middle Aged; Phenobar | 1982 |
[Studies on the mechanism of metabolic acidosis observed in the children treated with anticonvulsants].
Topics: Acidosis; Adolescent; Binding Sites; Calcium; Carbonic Anhydrases; Child; Child, Preschool; Drug The | 1982 |
[Mono- or polytherapy in the treatment of epileptic patients].
Topics: Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phen | 1983 |
Presenile cataracts in phenytoin-treated epileptic patients.
Topics: Adult; Aging; Animals; Cataract; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Rodentia | 1983 |
Motor and sensory conduction velocities and electromyographic findings in man before and after carbamazepine treatment.
Topics: Carbamazepine; Electromyography; Epilepsy; Humans; Neural Conduction; Peripheral Nerves; Phenytoin | 1983 |
Serum concentration of clonazepam and the therapeutic effect of the drug.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepinones; Clonazepam; Epilepsy; Female; Humans; Male; M | 1983 |
Hypermetabolism of phenytoin as a cause of treatment failure.
Topics: Adult; Drug Resistance; Epilepsy; Humans; Kinetics; Male; Phenytoin | 1983 |
Effect of cimetidine on phenytoin serum levels.
Topics: Cimetidine; Drug Synergism; Epilepsy; Guanidines; Humans; Male; Phenytoin | 1983 |
Falsely localizing ictal onsets with depth EEG telemetry during anticonvulsant withdrawal.
Topics: Adult; Electroencephalography; Epilepsy; Humans; Male; Meningeal Neoplasms; Meningioma; Phenytoin; S | 1983 |
The influence of bilirubin, alcohol and certain drugs on the kinetics of 99mTc-Diethyl IDA (EHIDA) in humans.
Topics: Alcoholism; Bilirubin; Epilepsy; Ethanol; Humans; Imino Acids; Jaundice; Kinetics; Phenobarbital; Ph | 1983 |
[Monitoring of plasma diphenylhydantoin levels in epileptic patients].
Topics: Adolescent; Adult; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infant | 1983 |
High-performance liquid chromatographic determination of phenytoin and hydroxyphenytoin in human urine.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Epilepsy; Female; Humans; Male; Middle Aged; Phen | 1983 |
[Radioimmunologic study of the plasma concentrations of folic acid and various antiepileptic preparations during the treatment of epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Benzamidines; Drug Therapy, Combination; Epilepsy; Female; Folic | 1983 |
Phenytoin in pregnancy: a review of the reported risks.
Topics: Abnormalities, Drug-Induced; Blood Coagulation Disorders; Epilepsy; Female; Humans; Infant; Infant, | 1983 |
Epileptic seizures controlled with paramethadione/primidone.
Topics: Animals; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Male; Oxazoles; Phenytoin; Primido | 1981 |
A study of the action of anticonvulsant drugs on an experimental model of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Electric Stimulation; Epi | 1980 |
Dental root abnormalities and gingival overgrowth in epileptic patients receiving anticonvulsant therapy.
Topics: Adolescent; Adult; Child; Epilepsy; Female; Gingival Hyperplasia; Humans; Intellectual Disability; M | 1980 |
Anticonvulsants and mental symptoms.
Topics: Anticonvulsants; Barbiturates; Biogenic Amines; Epilepsy; Folic Acid Deficiency; Hormones; Humans; M | 1980 |
Anticonvulsant drugs, cognitive function and memory.
Topics: Anticonvulsants; Carbamazepine; Double-Blind Method; Epilepsy; Humans; Male; Memory Disorders; Menta | 1980 |
Prescribing patterns for epilepsy.
Topics: Adult; Anticonvulsants; Child; Drug Prescriptions; Drug Therapy, Combination; Drug Utilization; Epil | 1981 |
Elementary pharmacokinetics in clinical practice. 3: Practical pharmacokinetic applications.
Topics: Administration, Oral; Biopharmaceutics; Dose-Response Relationship, Drug; Epilepsy; Humans; Injectio | 1981 |
Carbamazepine. Pharmacology and clinical uses.
Topics: Adult; Alcohol Withdrawal Delirium; Arrhythmias, Cardiac; Behavior; Carbamazepine; Child; Diabetes I | 1981 |
[Gingival fibromatosis associated with bilateral palatal fibromas].
Topics: Adult; Epilepsy; Female; Fibroma; Gingival Hyperplasia; Humans; Palatal Neoplasms; Phenytoin | 1982 |
[Combined surgical and prosthetic rehabilitation of epileptics].
Topics: Denture, Complete; Epilepsy; Gingival Hyperplasia; Gingivectomy; Gingivoplasty; Humans; Phenytoin; T | 1982 |
Binge eating - therapeutic response to diphenylhydantoin: case report.
Topics: Adult; Electroencephalography; Epilepsy; Feeding and Eating Disorders; Female; Humans; Hyperphagia; | 1982 |
Effect of 5,5-diphenylhydantoin on a gingival hyperplasia development.
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Gingiva; Gingival Hyperplasia; Humans; | 1980 |
Phenytoin intoxication and cotrimoxazole.
Topics: Adult; Drug Combinations; Drug Interactions; Epilepsy; Humans; Male; Phenytoin; Sulfamethoxazole; Tr | 1981 |
Some immunological reactions during chronic treatment with antiepileptic drugs.
Topics: Adult; Antibody Formation; B-Lymphocytes; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; | 1981 |
Lymphocyte subpopulations and lymphocyte function in phenytoin-treated patients with epilepsy.
Topics: Adolescent; Adult; Aged; Dysgammaglobulinemia; Epilepsy; Female; Humans; IgA Deficiency; Leukocytes; | 1982 |
Serum vitamin D metabolites in epileptic patients treated with 2 different anti-convulsants.
Topics: 24,25-Dihydroxyvitamin D 3; Adult; Aged; Alkaline Phosphatase; Calcifediol; Calcitriol; Calcium; Car | 1982 |
Effect of single doses of sodium valproate on serum phenytoin levels and protein binding in epileptic patients.
Topics: Adult; Blood Proteins; Epilepsy; Humans; Kinetics; Male; Phenytoin; Protein Binding; Valproic Acid | 1980 |
Epilepsy and the oral manifestations of phenytoin therapy.
Topics: Animals; Anticonvulsants; Epilepsy; Gingival Hypertrophy; History, Ancient; History, Medieval; Histo | 1981 |
[The determination of anticonvulsant drug levels in blood by enzyme immunoassay: method and clinical application (author's transl)].
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Immunoenzyme Techniques; Male; P | 1980 |
Antibodies to Escherichia coli and serum immunoglobulin levels in epileptics on long-term anticonvulsant therapy.
Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Antibodies, Bacterial; Epilepsy; Esch | 1981 |
Stability of antiepileptic drug level in serum. Reliability of enzyme immunoassay method.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Immunoenzyme Techniques; Phenobarbital; Phe | 1980 |
[Therapy control by determination of serum drug concentrations].
Topics: Asthma; Drug Therapy; Epilepsy; Humans; Phenytoin; Quality Control; Reference Standards; Theophyllin | 1982 |
Age and phenytoin kinetics in adult epileptics.
Topics: Adult; Aged; Aging; Epilepsy; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; | 1982 |
Comparative study of bioavailabilities of different phenytoin preparations.
Topics: Administration, Oral; Adolescent; Biological Availability; Child; Child, Preschool; Dose-Response Re | 1982 |
[Reduction of biotin level as a possible factor in the mode of action of anticonvulsants (author's transl)].
Topics: Adult; Anticonvulsants; Biotin; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Female; Hu | 1982 |
Drug interactions on an alcohol unit.
Topics: Adult; Alcoholism; Ataxia; Diagnosis, Differential; Drug Interactions; Epilepsy; Humans; Male; Oxaze | 1982 |
Serum elevation of high density lipoprotein (HDL) cholesterol in epileptic patients taking carbamazepine or phenytoin.
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Cholesterol; Cholesterol, HDL; Epilepsy; | 1982 |
Combined fetal alcohol and hydantoin syndromes.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Alcoholism; Epilepsy; Female; Fetal Alc | 1982 |
[Humoral and cell-mediated immunities in epileptic patients (author's transl)].
Topics: Adolescent; Adult; Antibody Formation; Complement System Proteins; Epilepsy; Female; Humans; Immunit | 1982 |
Quality of care of epilepsy in Italy: multi-hospital survey of diagnosis and treatment of 1104 epileptic patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Health Surveys; | 1982 |
Comparative bioavailability of phenytoin from generic formulations in the United Kingdom.
Topics: Adult; Aged; Biological Availability; Dosage Forms; Epilepsy; Humans; Middle Aged; Phenytoin; Tablet | 1982 |
Diphenylhydantoin excretion in the semen of treated epileptics.
Topics: Adolescent; Adult; Epilepsy; Humans; Male; Phenytoin; Semen | 1982 |
Prediction of phenytoin dosage in epilepsy using multiple linear regression.
Topics: Body Weight; Dose-Response Relationship, Drug; Epilepsy; Humans; Phenytoin | 1982 |
Cerebrospinal fluid and blood thiamine concentrations in phenytoin-treated epileptics.
Topics: Epilepsy; Folic Acid; Humans; Middle Aged; Phenytoin; Thiamine | 1982 |
Phenytoin influence on human lymphocyte mitogen response: a prospective study of epileptic and nonepileptic patients.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Concanavalin A; Epilepsy; Female; Humans; Immunogl | 1982 |
Comparison of phenytoin and phenobarbital effects on far-field auditory and somatosensory evoked potential interpeak latencies.
Topics: Epilepsy; Evoked Potentials, Auditory; Evoked Potentials, Somatosensory; Humans; Phenobarbital; Phen | 1982 |
Is there a climatic influence on the blood level of anticonvulsive drugs?
Topics: Climate; Epilepsy; Hot Temperature; Humans; Humidity; Phenytoin; Sweating | 1982 |
[Phenytoin serum concentration in epileptic patients: influence of therapeutic and physiological factors (author's transl)].
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Fema | 1982 |
Phenytoin: an inhibitor and inducer of primidone metabolism in an epileptic patient.
Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Phenobarbital; Phenylethylmalonamide; Phenytoin; | 1982 |
Plasma protein binding of phenytoin in 100 epileptic patients.
Topics: Adolescent; Adult; Aged; Blood Proteins; Child; Child, Preschool; Drug Interactions; Epilepsy; Femal | 1982 |
Therapeutic failures in epileptic children due to impaired diphenylhydantoin bioavailability.
Topics: Biological Availability; Child; Epilepsy; Humans; Phenytoin | 1982 |
Differences between the concentrations of antiepileptic drugs in normal and pathological human brain.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Carbamazepine; Child; Electroencephalography; Epilepsy; F | 1982 |
Urine and plasma free phenytoin concentration correlation.
Topics: Adolescent; Adult; Child; Chromatography, Gas; Epilepsy; Humans; Middle Aged; Phenytoin | 1982 |
Hypertrophic retroauricular folds attributable to diphenylhydantoin therapy.
Topics: Adult; Ear, External; Epilepsy; Humans; Hypertrophy; Male; Phenytoin; Skin; Skin Diseases; Time Fact | 1982 |
[Serum beta-glucuronidase activity in patients treated with phenobarbital and diphenylhydantoin].
Topics: Adult; Drug Therapy, Combination; Enzyme Induction; Epilepsy; Female; Glucuronidase; Humans; Liver; | 1982 |
Zinc and copper metabolism in phenytoin therapy.
Topics: Adult; Aged; Anticonvulsants; Copper; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Mid | 1982 |
[Diphenylhydantoin in the comprehensive treatment of epileptic attacks].
Topics: Adolescent; Adult; Aged; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin | 1982 |
HLA antigens in epileptic patients with drug-induced immunodeficiency.
Topics: Adult; Anticonvulsants; Carbamazepine; Dysgammaglobulinemia; Epilepsy; Female; HLA Antigens; Humans; | 1982 |
Rapid and slow release phenytoin in epileptic patients at steady state: comparative plasma levels and toxicity.
Topics: Adolescent; Adult; Delayed-Action Preparations; Epilepsy; Female; Humans; Kinetics; Male; Middle Age | 1982 |
Rapid and slow release phenytoin in epileptic patients at steady state: assessment of relative bioavailability utilizing Michaelis-Menten parameters.
Topics: Biological Availability; Delayed-Action Preparations; Epilepsy; Humans; Kinetics; Phenytoin | 1982 |
[Results of phenytoin monitoring in patients with epilepsy].
Topics: Adult; Epilepsy; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Phenytoin | 1982 |
Drug interactions during anticonvulsant medication.
Topics: Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phen | 1982 |
Immunoglobulins in epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Fe | 1982 |
[Cytogenetic study of diphenylhydantoin therapy using SCE].
Topics: Adult; Crossing Over, Genetic; Epilepsy; Humans; Mutagens; Phenytoin; Sister Chromatid Exchange | 1982 |
[Effectiveness of anticonvulsant monotherapy with phenytoin in relation to its plasma levels].
Topics: Adult; Epilepsy; Humans; Phenytoin | 1982 |
Phenytoin elimination in childhood: effect of concentration-dependent kinetics.
Topics: Adolescent; Adult; Age Factors; Biopharmaceutics; Child; Child, Preschool; Drug Administration Sched | 1980 |
Plasma levels and clinical effects of antiepileptic drugs in pregnant epileptic patients and their newborns.
Topics: Adult; Anticonvulsants; Clonazepam; Epilepsy; Female; Humans; Infant, Newborn; Phenobarbital; Phenyt | 1980 |
Predicting individual phenytoin serum levels of patients seen in a private office practice.
Topics: Epilepsy; Humans; Metabolic Clearance Rate; Phenytoin | 1981 |
Nonlinear kinetics of phenytoin in children.
Topics: Adolescent; Adult; Age Factors; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, | 1982 |
Cerebellar atrophy in epilepsy and headache: lack of relationship to phenytoin.
Topics: Adolescent; Adult; Atrophy; Cerebellum; Epilepsy; Female; Headache; Humans; Male; Phenytoin; Tomogra | 1982 |
Reversal by phenytoin of carbamazepine-induced water intoxication: a pharmacokinetic interaction.
Topics: Adult; Carbamazepine; Drug Antagonism; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Mi | 1980 |
Saliva phenobarbital and phenytoin concentrations in epileptic adolescents.
Topics: Adolescent; Child; Epilepsy; Female; Humans; Male; Patient Compliance; Phenobarbital; Phenytoin; Sal | 1981 |
Mianserin and epilepsy.
Topics: Adult; Depressive Disorder; Dibenzazepines; Epilepsy; Humans; Male; Mianserin; Phenytoin; Seizures | 1980 |
[Medication reliability of epileptic children treated with phenytoin].
Topics: Adolescent; Ambulatory Care; Child; Epilepsy; Female; Humans; Male; Patient Compliance; Phenytoin; S | 1980 |
[Measurements of nerve conduction velocity during decreasing toxic diphenylhydantoin levels and the beginning of carbamazepine medication. A clinical neurophysiological documentation (author's transl)].
Topics: Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Humans; Male; Middle Aged; Motor Neurons; | 1981 |
Anterior spinal artery syndrome during the postpartum period.
Topics: Adult; Cerebral Hemorrhage; Epilepsy; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange | 1981 |
[Determination of optimal diphenylhydantoin dosage by monitoring serum concentrations].
Topics: Aged; Brain; Epilepsy; Humans; Middle Aged; Phenytoin; Postoperative Care | 1980 |
The teratological problem of antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Adult; Animals; Anticonvulsants; Chromosome Aberrations; Cleft Lip; Cle | 1980 |
Therapeutic plasma concentration in epileptics treated with phenytoin alone.
Topics: Epilepsy; Humans; Phenytoin | 1980 |
Clinical effects of phenytoin (PHT) against various epileptic seizure types: investigation on effective serum concentration.
Topics: Adolescent; Adult; Child; Epilepsy; Female; Humans; Middle Aged; Phenytoin | 1980 |
Michaelis-Menten pharmacokinetics of diphenylhydantoin and application in the pediatric age patient.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Infant; Kinetics; Phenytoin | 1980 |
Quantitative assessment of smooth-pursuit eye movements in healthy and epileptic subjects.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Electrooculography; Epilepsy; Eye Movements; Huma | 1980 |
[Phenobarbital intoxication in a patient with primidone and diphenylhydantoin (author's transl)].
Topics: Adult; Drug Interactions; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Primidone | 1980 |
Clinical utility of six methods of predicting phenytoin doses and plasma concentrations.
Topics: Adult; Aged; Epilepsy; Female; Humans; Male; Methods; Middle Aged; Patient Compliance; Phenytoin | 1981 |
Rapid infusion of phenytoin sodium loading doses.
Topics: Blood Pressure; Epilepsy; Half-Life; Humans; Infusions, Parenteral; Phenytoin | 1981 |
[Influence of anti-epileptic drugs on blood lipid parameters: preliminary data].
Topics: Anticonvulsants; Carbamazepine; Cholesterol; Epilepsy; Humans; Lipids; Phenobarbital; Phenytoin; Tri | 1981 |
Ictal effects of anticonvulsant medication withdrawal in epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy; Humans; Middle | 1981 |
Chromosomal investigations in epileptic children during long-term therapy with phenytoin or primidone.
Topics: Adolescent; Cells, Cultured; Child; Child, Preschool; Chromosome Aberrations; Chromosomes, Human; Ep | 1981 |
Cardiovascular and hematologic effects of diphenylhydantoin in maternal and fetal sheep.
Topics: Acid-Base Equilibrium; Alkalosis; Animals; Blood Pressure; Cardiovascular System; Epilepsy; Female; | 1981 |
Phenytoin and IgA concentrations in plasma and saliva in epileptic children.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Immunoglobulin A; Male; Phenytoin; Sa | 1981 |
[Polytherapy and monotherapy in the treatment of epileptic patients].
Topics: Adult; Computers; Drug Combinations; Epilepsy; Female; Humans; Male; Monitoring, Physiologic; Phenob | 1981 |
[Neurological signs in diphenylhydantoin intoxication (case reports and review) (author's transl)].
Topics: Adult; Biopsy; Cerebellar Ataxia; Electroencephalography; Epilepsy; Evoked Potentials; Female; Human | 1981 |
Salivary anticonvulsant levels in children with epilepsy.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Epilepsy; Humans; Infant; Phenytoin; Saliva | 1981 |
[Epilepsy and hypocalcemia. Further considerations on a case].
Topics: Adult; Calcium; Epilepsy; Female; Goiter; Humans; Hypocalcemia; Hypoparathyroidism; Phenobarbital; P | 1981 |
Anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fe | 1981 |
Choreo-athetosis induced by phenytoin in an epileptic child. A case report.
Topics: Athetosis; Child, Preschool; Chorea; Epilepsy; Humans; Male; Phenytoin | 1981 |
Effect of phenytoin on immunoglobulin concentrations in nasal secretions.
Topics: Adolescent; Adult; Aged; Albumins; Child; Epilepsy; Humans; Immunoglobulin A; Immunoglobulin G; Immu | 1981 |
Effects of phenytoin withdrawal on matching to sample and workshop performance of mentally retarded persons.
Topics: Adolescent; Adult; Color Perception; Discrimination Learning; Epilepsy; Female; Humans; Intellectual | 1981 |
Chronic anticonvulsive therapy, peripheral nerve conduction velocity, and EMG.
Topics: Adult; Anticonvulsants; Electromyography; Epilepsy; Female; Humans; Male; Middle Aged; Neural Conduc | 1981 |
Plasma level analysis of some antiepileptic drugs in 180 patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilep | 1980 |
The relationship between the serum levels of phenobarbital and diphenylhydantoin and clinical data in patients with drug resistant epilepsy.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Resistance; Electroencephalography; Epilepsy; Femal | 1980 |
Possible drug interaction in chronic treatment of epileptic patients: serum level studies.
Topics: Adolescent; Adult; Anticonvulsants; Brain Damage, Chronic; Chronic Disease; Clonazepam; Drug Interac | 1980 |
A follow-up study of 880 adult ambulatory epileptics.
Topics: Adult; Age Factors; Employment; Epilepsy; Female; Follow-Up Studies; Humans; Male; Middle Aged; Phen | 1980 |
Smooth pursuit eye movements in epileptics under antiepileptic medication.
Topics: Adult; Aged; Anticonvulsants; Cerebellum; Epilepsy; Eye Movements; Female; Humans; Male; Middle Aged | 1981 |
Phenytoin and phenobarbitone plasma level-dose relationships in Chinese epileptic children in Singapore.
Topics: Adolescent; Child; Child, Preschool; China; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; P | 1981 |
Role of carbamazepine in reducing polypharmacy in epilepsy.
Topics: Acetazolamide; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Ther | 1981 |
Folic acid absorption test in various clinical conditions.
Topics: Adult; Aged; Atrophy; Diabetes Mellitus; Epilepsy; Folic Acid; Gastrointestinal Diseases; Humans; Hy | 1981 |
Protein-bound and free plasma phenytoin during pregnancy.
Topics: Blood Proteins; Epilepsy; Female; Fetus; Humans; Ovulation Induction; Phenytoin; Pregnancy; Pregnanc | 1981 |
[Monotherapy or polytherapy in epilepsy?].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Combinations; Drug Evaluation; Drug I | 1981 |
Serum phenytoin concentration and clinical response in patients with epilepsy.
Topics: Adolescent; Adult; Epilepsy; Female; Handwriting; Humans; Male; Memory, Short-Term; Middle Aged; Mot | 1981 |
[Diphenylhydantoin, epilepsy, cerebellar atrophy--histological and electron microscope examinations (author's transl)].
Topics: Adult; Atrophy; Cerebellar Diseases; Cerebellum; Endoplasmic Reticulum; Epilepsy; Female; Humans; Ma | 1981 |
[Bioavailability of phenytoin. Comparison of data obtained in vitro, in healthy volunteers and in epileptic patients].
Topics: Adolescent; Adult; Biological Availability; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin | 1981 |
[Diagnosis of osteopathy caused by antiepileptic drugs].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Bone Diseases; Carbamazepine; Epilepsy; Female; Femur; Han | 1981 |
Apparent Michaelis-Menten kinetic parameters of phenytoin in pediatric patients.
Topics: Adolescent; Aging; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Hu | 1980 |
From the NIH: Some side effects of phenytoin are studied.
Topics: Adult; Animals; Blood; Child; Epilepsy; Female; Fetus; Gingiva; Gingival Hypertrophy; Humans; Matern | 1980 |
Micropsia: an uncommon pediatric symptom.
Topics: Child; Epilepsy; Humans; Male; Phenytoin; Size Perception; Vision Disorders | 1980 |
Improvement in antiepileptic drug levels following reduction of intervals between clinic visits.
Topics: Adolescent; Adult; Anticonvulsants; Appointments and Schedules; Carbamazepine; Epilepsy; Ethosuximid | 1980 |
Reduced seizure control due to spoiled phenytoin capsules.
Topics: Adult; Biological Availability; Drug Stability; Drug Storage; Epilepsy; Humans; Humidity; Male; Phen | 1980 |
Plasma high-density lipoprotein cholesterol in epileptics treated with various anticonvulsants.
Topics: Adult; Anticonvulsants; Carbamazepine; Cholesterol; Epilepsy; Female; Humans; Lipoproteins, HDL; Mal | 1980 |
The syndrome of aphasia, headaches, and left temporal spikes.
Topics: Adult; Aphasia; Electroencephalography; Epilepsy; Female; Headache; Humans; Middle Aged; Phenytoin; | 1980 |
Antiepileptic drug distribution in cerebral cortex, ammon's horn, and amygdala in man.
Topics: Adolescent; Adult; Amygdala; Anticonvulsants; Carbamazepine; Cerebral Cortex; Child; Epilepsy; Femal | 1980 |
[Paroxysmal dyskinesia during treatment with diphenylhydantoin].
Topics: Adult; Brain Diseases; Child; Child, Preschool; Diazepam; Dyskinesia, Drug-Induced; Epilepsy; Female | 1980 |
Multivariate statistical methods in toxicology: application to the analysis of outpatient clinical data for diphenylhydantoin and phenobarbital in the treatment of epilepsy.
Topics: Adolescent; Adult; Aging; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Sex | 1980 |
Inhibition of collagen breakdown by diphenylhydantoin.
Topics: Carbon Radioisotopes; Cells, Cultured; Collagen; Depression, Chemical; DNA; Epilepsy; Female; Gingiv | 1980 |
Monitoring 2-ethyl-2-phenylmalonamide in serum by gas-liquid chromatography: application to retrospective study in epilepsy patients dosed with primidone.
Topics: Adult; Carbamazepine; Chromatography, Gas; Drug Interactions; Epilepsy; Humans; Malonates; Middle Ag | 1980 |
Fetal hydantoin syndrome, neuroblastoma, and hemorrhagic disease in a neonate.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Epilepsy; Female; Humans; Hydantoins; Infant, | 1980 |
Antiepileptic drugs, the developing nervous system, and the pregnant woman with epilepsy.
Topics: Abnormalities, Drug-Induced; Central Nervous System; Epilepsy; Female; Fetus; Humans; Infant, Newbor | 1980 |
[Panmyelopathy in combined epilepsy therapy using ethosuccimide, diphenylhydantoin, and phenobarbital in childhood].
Topics: Child; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Humans; Pancytopenia; Phenobarbita | 1980 |
Phenytoin metabolism in pregnancy.
Topics: Adult; Epilepsy; Female; Fetal Blood; Humans; Kinetics; Phenytoin; Pregnancy; Pregnancy Complication | 1980 |
Practical and theoretical aspects of phenytoin administration. I. Relationship between dose and plasma concentration.
Topics: Adult; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; | 1980 |
Arrhythmogenic epilepsy: an hypothesis.
Topics: Adolescent; Adult; Arrhythmias, Cardiac; Carbamazepine; Digoxin; Electroencephalography; Electrophys | 1980 |
Anticonvulsant-induced unclassified porphyria.
Topics: Adult; Aminolevulinic Acid; Anticonvulsants; Diagnosis, Differential; Epilepsy; Humans; Male; Phenob | 1980 |
[Failure of diphenylhydantoin treatment in children].
Topics: Child; Epilepsy; Humans; Patient Compliance; Phenytoin | 1980 |
Rapid quantitative determination of underivatized carbamazepine, phenytoin, phenobarbital and p-hydroxyphenobarbital in biological fluids by packed column gas chromatography.
Topics: Adult; Carbamazepine; Chromatography, Gas; Epilepsy; Female; Gas Chromatography-Mass Spectrometry; H | 1980 |
Phenytoin-induced teratogenesis: a mouse model.
Topics: Animals; Disease Models, Animal; Epilepsy; Female; Mice; Mice, Neurologic Mutants; Phenytoin; Terato | 1981 |
[Reflections on epileptic personality changes].
Topics: Epilepsy; Female; Humans; Middle Aged; Personality; Personality Disorders; Phenytoin; Psychotherapy; | 1980 |
Hospital prescribing of phenytoin for epilepsy.
Topics: Adult; Drug Administration Schedule; Drug Therapy, Combination; England; Epilepsy; Humans; Outpatien | 1981 |
Respiratory disease and nasal immunoglobulin concentrations in phenytoin-treated epileptic patients.
Topics: Epilepsy; Humans; Immunoglobulins; Nasal Mucosa; Phenytoin; Respiratory Tract Diseases | 1981 |
Power spectral analysis of EEG characteristics during sleep in epileptics.
Topics: Adolescent; Adult; Carbamazepine; Circadian Rhythm; Electroencephalography; Epilepsy; Ethosuximide; | 1981 |
Diphenylhydantoin and primidone in tears.
Topics: Adult; Child; Epilepsy; Female; Humans; Male; Phenytoin; Primidone; Saliva; Tears | 1981 |
Effect of chronic administration of phenytoin on regional monoamine levels in rat brain.
Topics: Animals; Anticonvulsants; Brain; Chromatography, High Pressure Liquid; Dopamine; Epilepsy; Injection | 1995 |
Practical considerations in anticonvulsant therapy--Part 2.
Topics: Anticonvulsants; Benzodiazepines; Cost Control; Epilepsy; Ethosuximide; Humans; Monitoring, Physiolo | 1995 |
[A change in the thyroid status of children with epilepsy being treated with diphenylhydantoin].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Hu | 1995 |
Automated analysis of free and total concentrations of three antiepileptic drugs in plasma with on-line dialysis and high-performance liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Dialysis; Epilepsy; Humans; Ph | 1995 |
Positron emission tomographic study of late-onset cryptogenic symptomatic seizures.
Topics: Aged; Aged, 80 and over; Blood Flow Velocity; Brain Damage, Chronic; Cerebral Cortex; Diagnosis, Dif | 1995 |
Red cell folate levels in pregnant epileptic women.
Topics: Adult; Carbamazepine; Epilepsy; Erythrocytes; Female; Folic Acid; Follow-Up Studies; Humans; Phenyto | 1995 |
Carbamazepine, phenytoin, sex hormones, and sexual function in men with epilepsy.
Topics: Adolescent; Adult; Carbamazepine; Epilepsy; Follow-Up Studies; Humans; Male; Middle Aged; Phenytoin; | 1995 |
[Persistent cerebellar ataxia after toxic administration of diphenylhydantoin].
Topics: Arachnoid Cysts; Brain Diseases; Cerebellar Ataxia; Epilepsy; Humans; Male; Middle Aged; Phenytoin; | 1994 |
Interactions of phenobarbital and phenytoin with carbamazepine and its metabolites' concentrations, concentration ratios, and level/dose ratios in epileptic children.
Topics: Biotransformation; Carbamazepine; Child; Chromatography, High Pressure Liquid; Dose-Response Relatio | 1995 |
[NONMEM approach for estimating population pharmacokinetic parameters of phenytoin in Chinese epileptics].
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Middle Aged; Model | 1995 |
Metabolism of carbamazepine and co-administered anticonvulsants during pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenytoi | 1995 |
Anticonvulsant effect of intraventricular antiepileptic drugs. Experimental study.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Injections, Intraventricul | 1995 |
Predicting unbound phenytoin concentrations in patients receiving valproic acid: a comparison of two prediction methods.
Topics: Adult; Bias; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Pred | 1995 |
Is there a pathophysiological and therapeutic link between panic disorder and epilepsy?
Topics: Adult; Brain; Carbamazepine; Electroencephalography; Epilepsy; Female; Humans; Magnetic Resonance Im | 1995 |
Humoral and cellular immune parameters in untreated and phenytoin-or carbamazepine-treated epileptic patients.
Topics: Adolescent; Adult; Aged; Antibody Formation; B-Lymphocytes; Carbamazepine; Complement C3; Complement | 1994 |
Effect of phenytoin on phenobarbital pharmacokinetics in a patient with epilepsy.
Topics: Adult; Drug Interactions; Drug Monitoring; Epilepsy; Female; Humans; Phenobarbital; Phenytoin | 1995 |
Drugs for epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin | 1995 |
[Disorders of color perception and increase glare sensitivity in phenytoin and carbamazepine therapy. Ocular side effects of anticonvulsants].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Color Perception Tests; Color Vision Defec | 1995 |
Preventing omission errors.
Topics: Accidental Falls; Epilepsy; Female; Humans; Mandibular Fractures; Medication Errors; Middle Aged; Ph | 1995 |
[Sensitive physiologic perceptual tests for ocular side effects of drugs exemplified by various anticonvulsants].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Color Perception; Contrast Sensitivity; Da | 1995 |
[Changes in drug therapy and in seizure frequency in an institution for epilepsy patients between 1971 and 1986].
Topics: Aged; Aged, 80 and over; Anticonvulsants; Barbiturates; Carbamazepine; Drug Therapy, Combination; Dr | 1994 |
Antiepileptic treatment and risk for hepatobiliary cancer and malignant lymphoma.
Topics: Aged; Aged, 80 and over; Biliary Tract Neoplasms; Case-Control Studies; Epilepsy; Female; Humans; Li | 1995 |
Differential up-regulation of voltage-dependent Na+ channels induced by phenytoin in brains of genetically seizure-susceptible (E1) and control (ddY) mice.
Topics: Amphibian Proteins; Animals; Carrier Proteins; Cerebral Cortex; Epilepsy; Mice; Mice, Neurologic Mut | 1994 |
Comparison of community and institutional prescription of antiepileptic drugs for individuals with learning disabilities.
Topics: Adult; Ambulatory Care; Anticonvulsants; Cognition Disorders; Day Care, Medical; Drug Therapy, Combi | 1994 |
A comparative study of serum F protein and other liver function tests as an index of hepatocellular damage in epileptic patients.
Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Aspartate Aminotransferases; Carbamazepine; Chemical a | 1994 |
Delayed fatal agranulocytosis in an epileptic taking primidone and phenytoin.
Topics: Adult; Agranulocytosis; Drug Therapy, Combination; Epilepsy; Fatal Outcome; Humans; Male; Phenytoin; | 1994 |
Antiepileptics in the elderly. Pharmacoepidemiology and pharmacokinetics.
Topics: Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; H | 1994 |
Basilar invagination and mid-line skeletal abnormalities due to in utero exposure to phenytoin.
Topics: Adult; Arnold-Chiari Malformation; Bone Transplantation; Cleft Lip; Cleft Palate; Diseases in Twins; | 1994 |
Changes of thyroid hormone levels in epileptic patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Phenytoin; Thyrotropin; Thyro | 1994 |
Epilepsy treatment in The Netherlands. Comparison of matched groups of two medical centres.
Topics: Adolescent; Adult; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Female; gamma-Aminobutyric Acid; | 1994 |
Ataxia in institutionalized patients with epilepsy.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Anticonvulsants; Ataxia; Cerebellar Ataxia; Epilepsy; | 1994 |
MDR1 gene expression in brain of patients with medically intractable epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; | 1995 |
Phenytoin overdosage and cerebellar atrophy in epileptic patients: clinical and MRI findings.
Topics: Adult; Atrophy; Cerebellar Diseases; Cerebellum; Drug Overdose; Epilepsy; Female; Humans; Magnetic R | 1994 |
Holoprosencephaly and the teratogenicity of anticonvulsants.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Face; Female; Finge | 1994 |
Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy.
Topics: Adult; Atrophy; Cerebellum; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin | 1994 |
Bone mineral density measured by dual-energy x-ray absorptiometry and novel markers of bone formation and resorption in patients on antiepileptic drugs.
Topics: Absorptiometry, Photon; Adult; Alkaline Phosphatase; Bone Density; Bone Development; Bone Resorption | 1994 |
Effect of phenytoin on cortical epileptic foci in cerveau isolé rats.
Topics: Animals; Brain Stem; Cerebral Cortex; Cortical Synchronization; Decerebrate State; Electroencephalog | 1994 |
Status epilepticus: management and outcome of 107 episodes.
Topics: Adolescent; Adult; Aged; Chlormethiazole; Clinical Protocols; Diazepam; Epilepsy; Female; Humans; In | 1994 |
Interaction between phenytoin and fluoxetine.
Topics: Adult; Depressive Disorder; Dose-Response Relationship, Drug; Epilepsy; Fluoxetine; Humans; Male; Ph | 1994 |
Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Amino Acids, Cyclic; Analysis of Var | 1993 |
Dihydropyridine group of calcium channel antagonist in epilepsy.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Electrodes, Implanted; Electroencephalography; | 1994 |
Kohlschütter syndrome: syndrome of epilepsy--dementia--amelogenesis imperfecta.
Topics: Amelogenesis Imperfecta; Brain; Dementia; Epilepsy; Female; Humans; Infant; Male; Phenytoin; Psychom | 1993 |
Pharmacodynamic interactions between phenytoin and valproate: individual and combined antiepileptic and neurotoxic actions in mice.
Topics: Animals; Brain; Brain Diseases; Drug Interactions; Drug Synergism; Electroshock; Epilepsy; Female; M | 1994 |
Carbamazepine offers no psychotropic advantage over phenytoin in adult epileptic subjects.
Topics: Adult; Carbamazepine; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Humans; In | 1993 |
Pregnancy, epilepsy, management and outcome: a 10-year perspective.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Birth Weight; Carbamazepine; Cohort Studies; Drug Ther | 1993 |
Acute psychosis and epileptic seizures as the presenting symptom of late-onset epilepsy.
Topics: Aged; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalo | 1994 |
[Gelastic seizures, precocious puberty and hypothalamic hamartomas. A case report and the contributions of Single Photon Emission Computed Tomography (SPECT)].
Topics: Adolescent; Epilepsy; Female; Hamartoma; Humans; Hypothalamus; Laughter; Magnetic Resonance Imaging; | 1994 |
[Repetitive serum determinations of anticonvulsants in epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Chronic Disease; Epilepsy; Female; Humans; Middle | 1993 |
Effects of non-opioid antitussives on hypoxia-induced electrical changes in rat hippocampal slices: a comparative study with anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Antitussive Agents; Cyclopentanes; Dizocilpine Maleate; Electrophysiology; | 1993 |
Neurophysiologic and clinical correlations of epileptic nystagmus.
Topics: Adult; Aged; Child; Consciousness; Diazepam; Electroencephalography; Epilepsy; Eye Movements; Female | 1993 |
Metabolic bone disease (anticonvulsant osteomalacia) and renal tubular acidosis in tuberous sclerosis.
Topics: Acidosis, Renal Tubular; Adult; Back Pain; Bicarbonates; Bone and Bones; Calcitriol; Calcium; Calciu | 1993 |
Phenytoin toxicity due to rifampicin induced hepatic dysfunction.
Topics: Chemical and Drug Induced Liver Injury; Child; Drug Interactions; Epilepsy; Female; Humans; Isoniazi | 1993 |
Automated determination of free phenytoin in human plasma with on-line equilibrium dialysis and column-switching high-performance liquid chromatography.
Topics: Autoanalysis; Blood Proteins; Chromatography, High Pressure Liquid; Dialysis; Epilepsy; Humans; Phen | 1993 |
Immunoglobulin A levels in serum and saliva of patients treated with phenytoin.
Topics: Adolescent; Adult; Dental Plaque Index; Epilepsy; Female; Gingival Hyperplasia; Humans; Immunoglobul | 1993 |
Unmasking the significant enzyme-inducing effects of phenytoin on serum carbamazepine concentrations during phenytoin withdrawal.
Topics: Adult; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Enzyme Induction; Epilepsy; Huma | 1993 |
Effect of barbiturate therapy on phenytoin pharmacokinetics.
Topics: Adult; Aged; Aged, 80 and over; Critical Illness; Epilepsy; Female; Humans; Intracranial Pressure; M | 1993 |
Free phenytoin monitoring in serum and saliva of epileptic patients in China.
Topics: Administration, Oral; Adolescent; Adult; China; Dialysis; Drug Monitoring; Epilepsy; Female; Fluores | 1993 |
Five years of anticonvulsant monitoring on site at the epilepsy clinic.
Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; Outpatient Clinics, Hospital; Phe | 1993 |
An audit of therapeutic drug monitoring of anticonvulsants.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Monitoring; Epilepsy; Humans; Medical Audit; Nort | 1995 |
Phenytoin serum concentration monitoring during pregnancy and puerperium in Mexican epileptic women.
Topics: Adolescent; Adult; Epilepsy; Female; Humans; Male; Phenytoin; Postpartum Period; Pregnancy; Pregnanc | 1995 |
A model for estimating individualized valproate clearance values in children.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Ther | 1995 |
Lack of effect of histological lesions on the phenytoin and phenobarbital concentrations in the brain cortex of epileptic patients.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Cerebellum; Cerebral Cortex; Child, Preschool; Epilep | 1995 |
Concentrations and effects of oral midazolam are greatly reduced in patients treated with carbamazepine or phenytoin.
Topics: Administration, Oral; Adult; Carbamazepine; Drug Interactions; Enzyme Induction; Epilepsy; Female; F | 1996 |
Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Phenobarbita | 1996 |
Pharmacology of cortical epileptic afterdischarges in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Dimethyl Sulfoxide; Disease Models, Animal | 1996 |
Anticonvulsants.
Topics: Anticonvulsants; Dental Care for Chronically Ill; Drug Interactions; Epilepsy; Gingival Hyperplasia; | 1994 |
Effect of valproate on cerebral metabolism and blood flow: an 18F-2-deoxyglucose and 15O water positron emission tomography study.
Topics: Adult; Brain; Carbamazepine; Cerebrovascular Circulation; Deoxyglucose; Dose-Response Relationship, | 1996 |
Use of parenteral antiepileptic drugs and the role for fosphenytoin.
Topics: Anticonvulsants; Epilepsy; Humans; Infusions, Parenteral; Phenytoin | 1996 |
[Study of the influence of anticonvulsant treatment on thyroid function].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Enzyme-Linked Immunosorbent Assay; E | 1995 |
Influence of D-cycloserine on the anticonvulsant activity of phenytoin and carbamazepine against electroconvulsions in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Carbamazepine; Cycloserine; Disease | 1996 |
[Subependymal nodular heterotopia and epilepsy].
Topics: Age of Onset; Anticonvulsants; Brain; Choristoma; Epilepsy; Female; Humans; Middle Aged; Pedigree; P | 1996 |
Anticonvulsant activity of topiramate and phenytoin in a rat model of ischemia-induced epilepsy.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Brain Ischemia; Epilepsy; Fructose; Male; Phenytoin; | 1996 |
Plasma and saliva concentrations of phenytoin and 5-(4-hydroxyphenyl)-5-phenylhydantoin in relation to the incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients.
Topics: Adult; Aged; Anticonvulsants; Epilepsy; Female; Gingival Hyperplasia; Humans; Male; Middle Aged; Phe | 1996 |
Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Half-Life; Humans; Metabolic Clearance Rate | 1996 |
A combined cobalt and C-14 2-deoxyglucose approach to antiepileptic drug assessment.
Topics: Animals; Anticonvulsants; Antimetabolites; Autoradiography; Brain Chemistry; Cobalt; Deoxyglucose; D | 1996 |
Magnetic resonance volumetry of the cerebellum in epileptic patients after phenytoin overdosages.
Topics: Adult; Cerebellum; Drug Overdose; Epilepsy; Female; Humans; Magnetic Resonance Imaging; Male; Middle | 1996 |
The necessity of adjusting the dosage of zonisamide when coadministered with other anti-epileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combinatio | 1996 |
Effect of CYP2C polymorphisms on the pharmacokinetics of phenytoin in Japanese patients with epilepsy.
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Sys | 1996 |
Salivary protein composition in epileptic patients on different medications.
Topics: Adult; Aged; Albumins; Amylases; Anticonvulsants; Carbamazepine; Cystatin C; Cystatins; Cysteine Pro | 1996 |
Drugs and brain death.
Topics: Adult; Australia; Brain Death; Brain Injuries; Cause of Death; Coroners and Medical Examiners; Epile | 1996 |
EBV-positive non-Hodgkin's lymphoma developing after phenytoin therapy.
Topics: Anticonvulsants; Antigens, CD20; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoco | 1996 |
Reduced plasma nisoldipine concentrations in phenytoin-treated patients with epilepsy.
Topics: Adult; Contraindications; Delayed-Action Preparations; Drug Interactions; Epilepsy; Female; Humans; | 1996 |
Severe transitory encephalopathy with reversible lesions of the claustrum.
Topics: Aphasia; Basal Ganglia Diseases; Blindness; Child; Deafness; Epilepsies, Myoclonic; Epilepsy; Epilep | 1996 |
Fosphenytoin safety and economics.
Topics: Anticonvulsants; Epilepsy; Humans; Phenytoin; Prescription Fees; Prodrugs | 1996 |
Valproate metabolites in high-dose valproate plus phenytoin therapy.
Topics: Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injur | 1996 |
Relationship between ischemic damage and concentrations of phenytoin and phenobarbital in the brain cortex of epileptic patients in vegetative state at death.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Autopsy; Brain Ischemia; Case-Control Studies; Cere | 1996 |
Effects of various valproic acid derivatives on low-calcium spontaneous epileptiform activity in hippocampal slices.
Topics: Animals; Anticonvulsants; Calcium; Carbohydrates; Electroshock; Epilepsy; Hippocampus; In Vitro Tech | 1995 |
Reactions to fosphenytoin editorial and review article.
Topics: Anticonvulsants; Cost Savings; Epilepsy; Humans; Phenytoin | 1997 |
Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy.
Topics: Animals; Anticonvulsants; Body Temperature; Calcium Channel Blockers; Disease Models, Animal; Electr | 1996 |
Phenytoin monitoring in pregnancy and puerperium.
Topics: Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications; Puerperal Disorders | 1997 |
Phenytoin-mediated oxidative stress in serum of female epileptics: a possible pathogenesis in the fetal hydantoin syndrome.
Topics: Analysis of Variance; Anticonvulsants; Copper; Epilepsy; Female; Glutathione; Humans; Lipid Peroxida | 1997 |
Single oral loading dose of phenytoin: a pharmacokinetics study.
Topics: Administration, Oral; Adult; Anticonvulsants; Case-Control Studies; Epilepsy; Female; Half-Life; Hum | 1997 |
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Color vision tests for early detection of antiepileptic drug toxicity.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Color Perception; Epilepsy; Humans; Osmolar Conce | 1997 |
Topiramate for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Int | 1997 |
Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain Stem; Disease Models, Animal; Dizocilpine Maleate; | 1997 |
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran | 1997 |
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran | 1997 |
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran | 1997 |
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran | 1997 |
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran | 1997 |
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran | 1997 |
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran | 1997 |
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran | 1997 |
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran | 1997 |
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran | 1997 |
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran | 1997 |
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran | 1997 |
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran | 1997 |
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran | 1997 |
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran | 1997 |
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin.
Topics: Animals; Anticonvulsants; Culture Techniques; Electroencephalography; Epilepsy; Hippocampus; Membran | 1997 |
[Therapy of the status epilepticus].
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Diagnosis, Differential; Epilepsy; Epilepsy, Tonic-C | 1994 |
Bone status after long-term anticonvulsant therapy in epileptic patients: evaluation using quantitative ultrasound of calcaneus and phalanges.
Topics: Adult; Anticonvulsants; Calcaneus; Carbamazepine; Case-Control Studies; Drug Therapy, Combination; E | 1997 |
Decreased total antioxidant capacity and elevated lipid hydroperoxide concentrations in sera of epileptic patients receiving phenytoin.
Topics: Antioxidants; Cholesterol; Epilepsy; Free Radicals; Humans; Lipid Peroxidation; Lipid Peroxides; Oxi | 1997 |
AWD 140-190: a new anticonvulsant with a very good margin of safety.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; E | 1997 |
[Pharmacokinetic variations in anticonvulsants in Mexican epileptic women during different stages of the postpartum period].
Topics: Animals; Anticonvulsants; Carbamazepine; Cricetinae; Epilepsy; Female; Humans; Milk, Human; Phenytoi | 1997 |
Single-point phenytoin dosage predictions in Singapore Chinese.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Drug Monitoring; Epilepsy; Female | 1997 |
Huge ossified crust-like subdural hematoma covering the hemisphere and causing acute signs of increased intracranial pressure.
Topics: Adolescent; Anticonvulsants; Brain Diseases; Calcinosis; Epilepsy; Hematoma, Subdural; Humans; Intra | 1997 |
Extrashot-ODS, a syringe-type minicolumn sample injector for a reversed-phase high-performance liquid chromatographic column. Application to antiepileptics in human sera.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Epi | 1997 |
Phenytoin's effect on the spread of seizure activity in the amygdala kindling model.
Topics: Animals; Anticonvulsants; Brain; Electroencephalography; Epilepsy; Female; Kindling, Neurologic; Mal | 1997 |
Influence of phenytoin on cortical epileptic afterdischarges.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Electric Stimulation; Electroencephalography; Epilepsy; P | 1996 |
If a first antiepileptic drug fails to control a child's epilepsy, what are the chances of success with the next drug?
Topics: Age of Onset; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cohort Studies; Drug Administ | 1997 |
Weak blockade of AMPA receptor-mediated depolarisations in the rat cortical wedge by phenytoin but not lamotrigine or carbamazepine.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Epilepsy; Evoked Potentials; Excitatory Am | 1997 |
BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response R | 1997 |
Risk of seizures from concomitant use of ciprofloxacin and phenytoin in patients with epilepsy.
Topics: Anti-Infective Agents; Anticonvulsants; Ciprofloxacin; Drug Interactions; Epilepsy; Humans; Phenytoi | 1998 |
Increased bFGF level in the serum of patients with phenytoin-induced gingival overgrowth.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Chromatography, High Pressure Liquid; Enzyme | 1998 |
Fetal hydantoin syndrome: an unusual cause of hip dysplasia.
Topics: Abnormalities, Drug-Induced; Acetabulum; Adult; Anticonvulsants; Epilepsy; Female; Hip Dislocation, | 1998 |
[Optimisation of epilepsy monotherapy (clinico-pharmacological study)].
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Chromatography, High Pressure Liquid; Electroencephalo | 1997 |
When the face tells the tale. Course facial features caused by phenytoin use.
Topics: Anticonvulsants; Epilepsy; Facial Expression; Facies; Humans; Male; Middle Aged; Phenytoin | 1998 |
Treatment of the epileptic patient in the dental office.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dental Care for Chronically Ill; Emergencies; Ep | 1998 |
Interictal cardiovascular autonomic responses in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Autonomic Nervous System; Blood Pressure; Epilepsy; Female; Hear | 1998 |
Does antiepileptic therapy affect immune response?
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbama | 1998 |
Comparison of anti-epileptic drug levels in different cases of sudden death.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Cause of Death; Child; Child, Preschool | 1998 |
Postmortem changes in blood concentrations of phenytoin and carbamazepine: an experimental study.
Topics: Animals; Anticonvulsants; Carbamazepine; Death, Sudden; Epilepsy; Humans; Phenytoin; Postmortem Chan | 1998 |
Antiepileptic drugs in developing countries.
Topics: Anticonvulsants; Child; Clinical Trials as Topic; Developing Countries; Epilepsy; Humans; India; Phe | 1998 |
Antiepileptic drugs in developing countries.
Topics: Anticonvulsants; Developing Countries; Drug Utilization; Epilepsy; Humans; Phenobarbital; Phenytoin | 1998 |
Changes in arrhythmia profile and heart rate variability during abrupt withdrawal of antiepileptic drugs. Implications for sudden death.
Topics: Adult; Aged; Analysis of Variance; Anticonvulsants; Arrhythmias, Cardiac; Autonomic Nervous System; | 1997 |
Benefits of a clinical pharmacokinetic service in optimising phenytoin use in the western Cape.
Topics: Ambulatory Care Facilities; Anticonvulsants; Epilepsy; Humans; Patient Compliance; Phenytoin; Referr | 1998 |
Age-dependent phenytoin effects on cortical stimulation in rats.
Topics: Age Factors; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Electric Stimulation | 1998 |
Limbic epileptogenesis alters the anticonvulsant efficacy of phenytoin in Sprague-Dawley rats.
Topics: Amygdala; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsy | 1998 |
Peripheral benzodiazepine receptor expression on leukocytes and neutrophil function during anticonvulsant monotherapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Leukocytes; Lymph | 1998 |
Antiepileptic drug use in nursing home residents: effect of age, gender, and comedication on patterns of use.
Topics: Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carb | 1998 |
Intravenous phenytoin: cheap but not necessarily a bargain.
Topics: Anticonvulsants; Drug Costs; Epilepsy; Humans; Injections, Intravenous; Phenytoin | 1998 |
Pharmacoeconomic considerations in treatment options for acute seizures.
Topics: Anticonvulsants; Child; Child, Preschool; Cost-Benefit Analysis; Diazepam; Economics, Pharmaceutical | 1998 |
Allergic hypersensitivity to antiepileptic drugs: past, present, and future.
Topics: Anticonvulsants; Child; Drug Hypersensitivity; Epilepsy; Forecasting; Germany; History, 20th Century | 1998 |
Quantifying the costs of serious adverse drug reactions to antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Direct Service Costs; Drug Costs; Drug Hypersensitivity; Epileps | 1998 |
Selection of phenytoin responders and nonresponders in male and female amygdala-kindled Sprague-Dawley rats.
Topics: Amygdala; Animals; Anticonvulsants; Drug Resistance; Epilepsy; Female; Kindling, Neurologic; Male; P | 1998 |
Paroxysmal kinesigenic choreoathetosis in Singapore and its relationship to epilepsy.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Athetosis; Carbamazepine; Child; Chorea; Comorbidi | 1998 |
[Serum lipids. lipoproteins, and apolipoproteins in adult epileptics treated with carbamazepine, valproic acid, or phenytoin].
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Apolipoproteins; Carbamazepine; Cholesterol; Choles | 1998 |
The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 E | 1998 |
A study of the pharmacokinetics of phenytoin (diphenylhydantoin) in epileptic patients, and the development of a nomogram for making dose increments.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Biological Availability; Clinical Pharmacy Information Sys | 1975 |
Comparison between premortem and postmortem serum concentrations of phenobarbital, phenytoin, carbamazepine and its 10,11-epoxide metabolite in institutionalized patients with epilepsy.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Hospitalization; H | 1999 |
Factors influencing the population pharmacokinetic parameters of phenytoin in adult epileptic patients in South Africa.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alcohol Drinking; Amino Acid Sequence; Anti | 1999 |
Phenytoin-associated thrombocytopenia in a toddler.
Topics: Anticonvulsants; Child, Preschool; Dandy-Walker Syndrome; Epilepsy; Female; Humans; Phenytoin; Throm | 1999 |
Determination of phenytoin in sections of head hair: a preliminary study to evaluate the history of drug use.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Chromatography, High Pressure Liquid; Epilepsy; Fem | 1998 |
Allergic skin reactions to anticonvulsant medications in patients receiving cranial radiation therapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Astrocytoma; Brain Neoplasms; Drug Eruptions; Drug Therapy | 1999 |
Elevated plasma concentrations of homocysteine in antiepileptic drug treatment.
Topics: Age Factors; Ambulatory Care; Anticonvulsants; Carbamazepine; Convulsants; Depression, Chemical; Epi | 1999 |
Bone mineral density of epileptic patients on long-term antiepileptic drug therapy: a quantitative digital radiography study.
Topics: Absorptiometry, Photon; Acetazolamide; Adult; Anticonvulsants; Barbiturates; Bone Density; Epilepsy; | 1999 |
Anticonvulsant and neurotoxic effects of intracerebroventricular injection of phenytoin, phenobarbital and carbamazepine in an amygdala-kindling model of epilepsy in the rat.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Injec | 1999 |
Systemic vasculitis associated with long-term phenytoin therapy.
Topics: Antibodies, Antinuclear; Anticonvulsants; Biopsy; Chronic Disease; Epilepsy; Humans; Male; Middle Ag | 1999 |
Phenytoin dosage adjustment in Saudi epileptics: utilization of steady-state pharmacokinetic parameters.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Child; Child, Preschool; Chromatography, Hi | 1999 |
Anticonvulsant hypersensitivity syndrome with an epoxide hydrolase defect.
Topics: Anticonvulsants; Drug Hypersensitivity; Epilepsy; Humans; Male; Middle Aged; Neurocysticercosis; Phe | 1999 |
Landau Kleffner syndrome.
Topics: Adolescent; Anticonvulsants; Clonazepam; Epilepsy; GABA Modulators; Humans; Hyperkinesis; Landau-Kle | 1998 |
Changes in phenytoin concentrations in blood and cerebrospinal fluid caused by direct hemoperfusion in a patient intoxicated with phenytoin.
Topics: Acute Disease; Anticonvulsants; Drug Monitoring; Epilepsy; Female; Hemoperfusion; Humans; Metabolic | 1998 |
Atrioventricular septal defect with separate right and left atrioventricular valvar orifices in a patient with foetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cardiac Catheterization; Echocardiography, Doppler; Ep | 1999 |
[Residual cerebellar ataxia following acute phenytoin intoxication].
Topics: Adult; Anticonvulsants; Atrophy; Brain; Brain Neoplasms; Cerebellar Ataxia; Cerebellum; Epilepsy; Hu | 1999 |
Temperature effect on serum protein binding kinetics of phenytoin in monotherapy patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Blood Proteins; Child; Child, Preschool; Epilepsy; Female; Human | 1999 |
Phenytoin metabolism to 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) in man, cat and rat in vitro and in vivo, and susceptibility to phenytoin-induced gingival overgrowth.
Topics: Adult; Aged; Animals; Anticonvulsants; Area Under Curve; Biotransformation; Cats; Chlorophyll; Chrom | 1999 |
Efficacy of statin therapy: possible effect of phenytoin.
Topics: Anticholesteremic Agents; Atorvastatin; Cytochrome P-450 Enzyme System; Drug Interactions; Epilepsy; | 1999 |
Paradoxical seizures in phenytoin toxicity.
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Middle Age | 1999 |
Malformations in offspring of women with epilepsy: a prospective study.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Comorbidity; Congenital Abnormalities; | 1999 |
Problem of managing patients with epilepsy in developing countries.
Topics: Anticonvulsants; Carbamazepine; Cost-Benefit Analysis; Developing Countries; Drug Costs; Economics, | 1999 |
Clinical experience with new antiepileptic drugs: antiepileptic drugs in Europe.
Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Cross-Cultural Comparison; Drug Approval; | 1999 |
Reversible total IgA deficiency associated with phenytoin treatment.
Topics: Anticonvulsants; Epilepsy; Humans; IgA Deficiency; Lung Diseases; Male; Middle Aged; Phenytoin | 1999 |
Subtherapeutic levels of phenytoin with standard doses in infants: need to review dosage schedule.
Topics: Anticonvulsants; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Epilepsy; | 1999 |
Practical management of therapeutic diphenylhydantoin concentrations in children.
Topics: Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Monitoring; Epileps | 1999 |
The effect of multiple anticonvulsant therapy on the expression of phenytoin-induced gingival overgrowth.
Topics: Adult; Anticonvulsants; Chromatography, High Pressure Liquid; Drug Interactions; Drug Therapy, Combi | 1999 |
Postoperative anticonvulsant prophylaxis for patients treated for cerebral aneurysms.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Craniotomy; Drug Administration Schedule; Epilepsy; | 1999 |
In vivo binding characteristics of phenytoin to serum proteins in monotherapy pediatric patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Blood Proteins; Child; Child, Preschool; Epilepsy; Female; Human | 2000 |
[Anesthetic management of a patient with West syndrome].
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Anticonvulsants; Epilepsy; Female; Hordeol | 2000 |
Elimination of phenytoin in toxic overdose.
Topics: Adult; Aged; Anticonvulsants; Drug Overdose; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; | 2000 |
Onset and duration of action of rocuronium in children receiving chronic anticonvulsant therapy.
Topics: Analysis of Variance; Androstanols; Anesthesia Recovery Period; Anticonvulsants; Carbamazepine; Case | 2000 |
Phenytoin as the first option in female epileptic patients?
Topics: Acne Vulgaris; Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Follow-Up Studies; Gingival Hyp | 1999 |
[Dupuytren's and Ledderhose's diseases associated with chronic use of anticonvulsants. Case report].
Topics: Adult; Anticonvulsants; Diazepam; Dupuytren Contracture; Epilepsy; Foot Diseases; Humans; Male; Phen | 1999 |
Anticonvulsant efficacy of topiramate in phenytoin-resistant kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Drug Resistance; Electric Stimulation; E | 2000 |
Phenytoin administration in the newborn and infant.
Topics: Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Infant; Infant, Newborn; Male; Phenytoi | 2000 |
Effects of topiramate on sustained repetitive firing and spontaneous recurrent seizure discharges in cultured hippocampal neurons.
Topics: Action Potentials; Animals; Anticonvulsants; Calcium Channels; Cells, Cultured; Dose-Response Relati | 2000 |
Homocysteine concentrations and methionine loading in patients on antiepileptic drugs.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Cytochrome P-450 Enzyme System; E | 2000 |
Kindling alters the anticonvulsant efficacy of phenytoin in Wistar rats.
Topics: Amygdala; Animals; Anticonvulsants; Electric Stimulation; Electrodes, Implanted; Epilepsy; Female; I | 2000 |
Changes in bone turnover and deoxypyridinoline levels in epileptic patients.
Topics: Adult; Alkaline Phosphatase; Amino Acids; Anticonvulsants; Bone and Bones; Calcium; Carbamazepine; C | 2000 |
[Drug resistant epilepsy in Senegal: therapeutic, clinical and socioeconomic factors].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Resistance; Epilepsy; Female; Humans; | 1999 |
[Phenytoin-induced hypersensitivity reaction with liver failure].
Topics: Anticonvulsants; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Administration Sche | 2000 |
Seizure-inducing paradoxical reaction to antiepileptic drugs.
Topics: Anticonvulsants; Clonazepam; Drug Therapy, Combination; Electroencephalography; Epilepsy; Female; Hu | 2000 |
[Dose-dependent relationship of chronic use of phenytoin and cerebellar atrophy in patients with epilepsy].
Topics: Adult; Anticonvulsants; Atrophy; Cerebellum; Dose-Response Relationship, Drug; Epilepsy; Female; Hum | 2000 |
Validation of population pharmacokinetic parameters of phenytoin using the parallel Michaelis-Menten and first-order elimination model.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Data Interpretation, Statistical; Dose- | 2000 |
Association of prenatal phenobarbital and phenytoin exposure with small head size at birth and with learning problems.
Topics: Adult; Anticonvulsants; Cephalometry; Cognition; Cross-Sectional Studies; Epilepsy; Female; Follow-U | 2000 |
A story of "Ayurvedic" tablets and misled epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epi | 1999 |
Absence of pharmacokinetic drug interaction of levetiracetam with phenytoin in patients with epilepsy determined by new technique.
Topics: Adult; Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Levetiraceta | 2000 |
Plasma total glutathione concentrations in epileptic patients taking anticonvulsants.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cysteine; Epilepsy; Glutathione; Humans; Oxidatio | 2000 |
A clinical study of 57 children with fetal anticonvulsant syndromes.
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep | 2000 |
An unresponsive patient with a history of stroke.
Topics: Aged; Anticonvulsants; Diagnosis, Differential; Drug Overdose; Epilepsy; Female; Humans; Phenytoin; | 1999 |
[Cerebellar damage caused by phenytoin intoxication].
Topics: Adolescent; Anticonvulsants; Cerebellar Ataxia; Drug Monitoring; Epilepsy; Female; Humans; Phenytoin | 1997 |
[Progressive, small spotted, confluent erythema with bullae formation and general symptoms. Acute Lyell syndrome].
Topics: Adult; Anticonvulsants; Diagnosis, Differential; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; S | 2000 |
Effect of sex on serum protein binding characteristics of phenytoin in pediatric patients with epilepsy.
Topics: Adolescent; Anticonvulsants; Blood Proteins; Child; Child, Preschool; Epilepsy; Female; Fluorescence | 2000 |
Bone mineral density, vitamin D and anticonvulsant therapy.
Topics: Adult; Anticonvulsants; Bone Density; Case-Control Studies; Epilepsy; Humans; Male; Phenobarbital; P | 2000 |
Epilepsy.
Topics: Animals; Anticonvulsants; Electrophysiology; Epilepsy; Humans; Mutation; Neurons; Phenytoin; Seizure | 2000 |
Effects of combined administration of zonisamide and valproic acid or phenytoin to nitric oxide production, monoamines and zonisamide concentrations in the brain of seizure-susceptible EL mice.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Interactions; Dru | 2000 |
Purple glove syndrome caused by oral administration of phenytoin.
Topics: Administration, Oral; Anticonvulsants; Child; Drug Overdose; Edema; Epilepsy; Extremities; Humans; M | 2000 |
[Prodilantin: a new antiepileptic?].
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; Humans; Phenytoin; Treatment Outcome | 2000 |
I. The modulatory effect in genotoxic responses due to age and duration of PHT-therapy in epileptic patients.
Topics: Adolescent; Adult; Age Factors; Age of Onset; Anticonvulsants; Child; Epilepsy; Female; Humans; Lymp | 2001 |
II. An altered proliferation response due to the anticonvulsant phenytoin (PHT) in epileptic patients.
Topics: Adolescent; Adult; Age Factors; Age of Onset; Anticonvulsants; Cell Cycle; Cell Division; Child; Epi | 2001 |
The teratogenicity of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Case-Control Studies; Congenital Abnorm | 2001 |
In vivo binding characteristics of phenytoin to serum proteins in monotherapy for adults with epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Blood Proteins; Epilepsy; Female; Humans; Kinetics; Male; | 2000 |
No gender effect on binding characteristics of phenytoin to serum proteins in monotherapy for adult patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Sex | 2000 |
Antiepileptic drug therapy and its management in sudden unexpected death in epilepsy: a case-control study.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Cohort Studies; Death, Sudd | 2001 |
Effect of temperature on serum protein binding characteristics of phenytoin in monotherapy paediatric patients with epilepsy.
Topics: Adolescent; Anticonvulsants; Blood Proteins; Child; Child, Preschool; Epilepsy; Female; Humans; Infa | 2001 |
[Reversible phenytoin-induced extrapontine myelinolysis].
Topics: Adult; Epilepsy; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Myelinolysis, Centra | 2001 |
Seizures at high altitude in a patient on antiseizure medications.
Topics: Anticonvulsants; Epilepsy; Humans; Male; Middle Aged; Mountaineering; Phenytoin; Seizures | 2001 |
The effect of genetic polymorphism of cytochrome P450 CYP2C9 on phenytoin dose requirement.
Topics: Adolescent; Adult; Aged; Alleles; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 C | 2001 |
Induction of hypersensitivity to a previously tolerated antiepileptic drug by a second antiepileptic drug.
Topics: Adult; Anticonvulsants; Carbamazepine; Cross Reactions; Drug Eruptions; Drug Hypersensitivity; Drug | 2001 |
Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain.
Topics: Animals; Anticonvulsants; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Drug Resist | 2001 |
Epilepsy.
Topics: Anticonvulsants; Automobile Driving; Epilepsy; Female; Guidelines as Topic; Humans; Phenytoin; Valpr | 2001 |
Genetic polymorphisms and functional characterization of the 5'-flanking region of the human CYP2C9 gene: in vitro and in vivo studies.
Topics: Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Bayes Theorem; Cytochrome P-450 CYP2C9; Cytoc | 2001 |
Are serum anticonvulsant levels in people with epilepsy appropriately monitored?
Topics: Anticonvulsants; Drug Monitoring; Epilepsy; Humans; Logistic Models; Phenytoin; Valproic Acid | 2001 |
Dietary iron reduces the anti-convulsion activity of phenytoin in electroconvulsion via inhibition of brain penetration.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Dose-Response Relationship, Drug; Drug Interac | 2001 |
Prevalence and risk of gingival enlargement in patients treated with anticonvulsant drugs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Anticonvulsants; Cross-Sectional Studi | 2001 |
[Analogs of generic preparations for the treatment of epilepsy: is their use safe?].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Child, Preschool; | 2001 |
Effects of antiepileptic drugs on afterdischarge generation in rat hippocampal slices.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Bicuculline; Carbamazepine; Dose-Respo | 2002 |
Intravenous diphenylhydantoin in treatment of acute repetitive seizures. 1968.
Topics: Acute Disease; Anticonvulsants; Epilepsy; History, 20th Century; Humans; Infusions, Intravenous; Phe | 2001 |
Anticonvulsants-induced chorea: a role for pharmacodynamic drug interaction?
Topics: Anticonvulsants; Child, Preschool; Chorea; Drug Synergism; Drug Therapy, Combination; Dyskinesia, Dr | 2001 |
An algorithm for monitoring phenytoin therapy.
Topics: Algorithms; Anticonvulsants; Epilepsy; Evidence-Based Medicine; Humans; Nurse Practitioners; Phenyto | 2000 |
Ophthalmic findings in fetal anticonvulsant syndrome(s).
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep | 2002 |
Fatal case of accidental intra-arterial phenytoin injection.
Topics: Accidents; Aged; Aged, 80 and over; Anticonvulsants; Arm; Epilepsy; Fatal Outcome; Female; Gangrene; | 2002 |
How high can we go with phenytoin?
Topics: Anticonvulsants; Child; Child, Hospitalized; Drug Monitoring; Epilepsy; Female; Glasgow Coma Scale; | 2002 |
Topiramate and phenytoin pharmacokinetics during repetitive monotherapy and combination therapy to epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochr | 2002 |
[Adverse effects of anti-epileptic drugs].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethos | 1975 |
Prognosis and therapy of complex partial seizures with barbiturates, hydantoins, and other drugs.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Drug Therapy, Combination; Epilepsy; Epilepsy, Tempo | 1975 |
Activity of gamma-glutamyl transpeptidase in serum of patients receiving anticonvulsant of anticoagulant therapy.
Topics: Alkaline Phosphatase; Anticoagulants; Anticonvulsants; Aspartate Aminotransferases; Epilepsy; gamma- | 1976 |
Resistant transitory epilepsy in children.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Carbamazepine; Child, Preschool; Encephalomyelitis, Ac | 1976 |
[Determination of phenobarbital, mephenytoin and diphenylhydantoin in the surveillance of anticonvulsant treatment].
Topics: Barbiturates; Child; Chromatography, Gas; Epilepsy; Ether; Humans; Hydantoins; Mephenytoin; Methylat | 1976 |
Anticonvulsant therapy and serum gamma-glutamyl-transferase.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Epilepsy; Female; gamma-Glutamyltran | 1978 |
Use of anticonvulsant drugs.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Epilepsy; Ethosuximide; Humans; Phenobarbital | 1979 |
Neuropsychological correlates of anticonvulsants and epileptiform discharges in adult epileptics.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy; Humans; Phenyto | 1978 |
Amines, anticonvulsants, and epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Chromatography, Gas; Drug Therapy, Combination; Epilepsy; | 1975 |
Letter: Bioavailability of drugs after intramuscular injection.
Topics: Absorption; Administration, Oral; Adult; Biological Availability; Biotransformation; Carbamazepine; | 1975 |
Letter: Amines, anticonvulsants, and epilepsy.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Humans; Hydroxyindoleacetic Ac | 1975 |
[Anticonvulsant drugs and liver damage (Author's transl)].
Topics: Adult; Anticonvulsants; Antitubercular Agents; Autopsy; Chemical and Drug Induced Liver Injury; Chol | 1975 |
Letter: Amines, anticonvulsants, and epilepsy.
Topics: Animals; Anticonvulsants; Brain; Epilepsy; Humans; Phenobarbital; Phenytoin; Rats; Serotonin | 1975 |
Letter: Word reversal during phenytoin therapy.
Topics: Adult; Aphasia; Epilepsy; Female; Humans; Phenytoin | 1975 |
Serum-phenytoin levels in management of epilepsy.
Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy; Humans; Phenytoin; Time Fa | 1975 |
Editorial: Drug levels in epilepsy.
Topics: Adult; Biological Availability; Child; Dose-Response Relationship, Drug; Drug Tolerance; Epilepsy; H | 1975 |
Letter: Phenytoin dosage.
Topics: Biological Availability; Dose-Response Relationship, Drug; Epilepsy; Humans; Phenytoin | 1975 |
EEG changes after withdrawal of medication in epileptic patients.
Topics: Adult; Anticonvulsants; Brain; Electroencephalography; Epilepsy; Humans; Phenobarbital; Phenytoin; P | 1975 |
The effect of phenytoin and ethosuximide on primidone metabolism in patients with epilepsy.
Topics: Drug Interactions; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Humans; Male; Phenobar | 1975 |
Letter: Drug levels in epilepsy.
Topics: Epilepsy; Humans; Phenytoin | 1975 |
Proceedings: Influence of a single intravenous dose of phenytoin on to EEG.
Topics: Adult; Child; Electroencephalography; Epilepsy; Humans; Injections, Intravenous; Phenytoin | 1975 |
IgA deficiency, epilepsy, and phenytoin treatment.
Topics: Adolescent; Cell Membrane; Child; Child, Preschool; Epilepsy; Female; Humans; IgA Deficiency; Immuno | 1975 |
Letter: Phenytoin dosage nomogram.
Topics: Epilepsy; Follow-Up Studies; Humans; Phenytoin; Retrospective Studies | 1975 |
Letter: Pyridoxine and serum concentration of phenytoin and phenobarbitone.
Topics: Child; Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Pyridoxine; Time Factors | 1976 |
Anticonvulsants and parental epilepsy in the development of birth defects.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Epilepsy; Female; Finland; Follow-Up Studies; | 1976 |
Letter: Serum-phenytoin and body-weight.
Topics: Adult; Body Weight; Dose-Response Relationship, Drug; Epilepsy; Humans; Male; Phenytoin | 1976 |
Letter: Immunosuppression by phenytoin.
Topics: Child, Preschool; Dysgammaglobulinemia; Epilepsy; Humans; Immunoglobulin A; Immunologic Deficiency S | 1976 |
Letter: Immunodeficiency and epilepsy.
Topics: Adolescent; Adult; Agammaglobulinemia; Autoimmune Diseases; Child; Dysgammaglobulinemia; Epilepsy; H | 1976 |
Letter: Anticonvulsants and fetal malformations.
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Phenobarbital; Phenytoin; Pr | 1976 |
Letter: Lymphocyte-count in children treated with phenytoin.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Epilepsy; Humans; Leukocyte Count; Lymphocytes; Ph | 1976 |
Letter: One drug (phenytoin) in treatment of epilepsy.
Topics: Drug Interactions; Epilepsy; Humans; Phenytoin | 1976 |
Salivary concentrations of antiepileptic drugs.
Topics: Epilepsy; Humans; Methods; Parotid Gland; Phenytoin; Saliva | 1976 |
VACTERL congenital malformation and phenytoin therapy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Epilepsy; Female; Humans; Infant, | 1976 |
Lymphocytes in children treated with phenytoin.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Infant; Leukocyte Count; Lymphocytes; Phenyto | 1976 |
Valproate may lower serum-phenytoin.
Topics: Drug Interactions; Epilepsy; Humans; Phenytoin; Valerates; Valproic Acid | 1976 |
How doctors deal with epilepsy.
Topics: Adolescent; Adult; Aged; Automobile Driving; Diazepam; Drug Therapy, Combination; Electroencephalogr | 1977 |
Serum-phenytoin, seizures, and electroencephalography.
Topics: Electroencephalography; Epilepsy; Humans; Phenytoin; Retrospective Studies | 1977 |
Salivary phenytoin concentrations in epilepsy and in chronic renal failure.
Topics: Adolescent; Adult; Biological Availability; Child; Child, Preschool; Epilepsy; Female; Humans; Kidne | 1976 |
Therapeutic and pharmacokinetic effects of increasing phenytoin in chronic epileptics on multiple drug therapy.
Topics: Adult; Biological Availability; Chronic Disease; Dose-Response Relationship, Drug; Drug Therapy, Com | 1976 |
In vivo interaction of anticonvulsant drugs. The mathematical correlation of plasma levels of anticonvulsant drugs in epileptic patients.
Topics: Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; In | 1978 |
Haematological effects of anticonvulsant treatment.
Topics: Anemia, Macrocytic; Epilepsy; Female; Humans; Male; Phenytoin | 1978 |
Haematological effects of anticonvulsant treatment.
Topics: Drug Therapy, Combination; Epilepsy; Erythrocyte Volume; Erythrocytes, Abnormal; Humans; Phenytoin; | 1978 |
Effects of anticonvulsant drugs on thyroid hormones in epileptic children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Cholesterol; Dose-Response Relationship, Drug; Dr | 1978 |
Coefficient of variation as measure of compliance.
Topics: Analysis of Variance; Epilepsy; Humans; Patient Compliance; Phenytoin | 1978 |
Anticonvulsant drugs and cancer. A cohort study in patients with severe epilepsy.
Topics: Adolescent; Adult; Brain Neoplasms; Child; England; Epilepsy; Female; Follow-Up Studies; Humans; Mal | 1979 |
Epilepsy in childhood.
Topics: Anticonvulsants; Child; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Humans; Infant; Infant, | 1978 |
Effect of carbamazepine, phenytoin and phenobarbitone on serum levels of thyroid hormones and thyrotropin in humans.
Topics: Adult; Carbamazepine; Epilepsy; Humans; Phenobarbital; Phenytoin; Radioimmunoassay; Thyroid Hormones | 1978 |
Bone morphology in epileptics.
Topics: Adult; Aged; Bone and Bones; Bone Diseases; Bone Resorption; Epilepsy; Female; Humans; Male; Middle | 1979 |
Bone mineral content in epileptics.
Topics: Aged; Bone and Bones; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged; Minerals; Muscle C | 1979 |
Childhood epilepsy uncontrolled by phenytoin: clinical and electroencephalographic study.
Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy | 1979 |
Valproic acid-phenytoin interaction.
Topics: Adult; Chromatography, Gas; Drug Interactions; Epilepsy; Humans; Monitoring, Physiologic; Phenytoin; | 1979 |
Letter: Exfoliative dermatitis during treatment with pheneturide.
Topics: Adult; Anticonvulsants; Dermatitis, Exfoliative; Epilepsy; Humans; Male; Phenobarbital; Phenylbutyra | 1975 |
Human epileptic brain Na, K ATPase activity and phenytoin concentrations.
Topics: Acetylcholinesterase; Adenosine Triphosphatases; Adolescent; Adult; Astrocytes; Brain; Child; Epilep | 1975 |
[Acne and phenytoin].
Topics: Acne Vulgaris; Adult; Epilepsy; Female; Humans; Phenytoin; Time Factors | 1977 |
[Phenytoin-induced acne].
Topics: Acne Vulgaris; Adult; Cysts; Drug Eruptions; Drug Hypersensitivity; Epilepsy; Female; Humans; Phenyt | 1977 |
Seizure activity and anticonvulsant drug concentration.
Topics: Anticonvulsants; Child; Circadian Rhythm; Diazepam; Dose-Response Relationship, Drug; Drug Administr | 1975 |
Patients with epilepsy.
Topics: Affective Symptoms; Age Factors; Alcoholism; Barbiturates; Child; Child, Preschool; Craniocerebral T | 1975 |
Calcium and folic acid absorption in patients taking anticonvulsant drugs.
Topics: Adult; Aged; Calcium; Cholecalciferol; Epilepsy; Folic Acid; Humans; Male; Middle Aged; Osteomalacia | 1975 |
Motor nerve conduction study in patients on diphenylhydantoin therapy.
Topics: Adolescent; Adult; Epilepsy; Folic Acid; Humans; Male; Middle Aged; Motor Neurons; Neural Conduction | 1975 |
[Hepatocellular adenoma].
Topics: Abdomen; Adult; Carcinoma, Hepatocellular; Epilepsy; Hemorrhage; Humans; Liver Neoplasms; Male; Phen | 1976 |
Prophylactic effects of phenytoin, phenobarbital, and carbamazepine examined in kindling cat preparations.
Topics: Animals; Carbamazepine; Cats; Disease Models, Animal; Drug Evaluation, Preclinical; Electric Stimula | 1976 |
Effects of diphenylhydantoin in 41 epileptics institutionalized since childhood.
Topics: Adolescent; Adult; Alkaline Phosphatase; Anemia; Central Nervous System Diseases; Child; Epilepsy; F | 1977 |
Reversible subacute peripheral neuropathy induced by phenytoin.
Topics: Adult; Epilepsy; Female; Humans; Peripheral Nervous System Diseases; Phenytoin; Reflex, Abnormal | 1977 |
[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, Preschool; Clonazepam; Dia | 1977 |
Increase of serum high-density lipoprotein in phenytoin users.
Topics: Adult; Apolipoproteins; Cholesterol; Epilepsy; Female; Humans; Lipoproteins, HDL; Male; Middle Aged; | 1978 |
Elevation of high-density lipoprotein in epileptic patients treated with phenytoin.
Topics: Adult; Cholesterol; Epilepsy; Female; Humans; Hypertrophy; Lipids; Lipoproteins; Lipoproteins, HDL; | 1978 |
[Neurotransmission mechanisms underlying seizures and epilepsies (author's transl)].
Topics: Acetylcholine; Amino Acids; Animals; Catecholamines; Electroencephalography; Epilepsy; Humans; Pheny | 1978 |
Plasma high-density lipoproteins.
Topics: Age Factors; Animals; Coronary Disease; Epilepsy; Female; Humans; Infant; Infant, Newborn; Lipoprote | 1979 |
Drug interactions in epilepsy.
Topics: Anticonvulsants; Child; Depression, Chemical; Drug Interactions; Epilepsy; Humans; Phenytoin; Thiazi | 1975 |
The drug management of acute behavioural disturbances.
Topics: Acting Out; Acute Disease; Adrenergic beta-Antagonists; Aged; Antidepressive Agents, Tricyclic; Anti | 1975 |
Plasma albumin concentration and diphenylhydantoin binding in man.
Topics: Adolescent; Adult; Aged; Aspirin; Blood Protein Electrophoresis; Blood-Brain Barrier; Chromatography | 1975 |
Involuntary movements caused by phenytoin intoxication in epileptic patients.
Topics: Adult; Chlorpheniramine; Diazepam; Drug Interactions; Drug Therapy, Combination; Electroencephalogra | 1975 |
[Effects of combination of anti-epileptic drugs].
Topics: Adrenergic beta-Antagonists; Anticonvulsants; Benzodiazepines; Carbamazepine; Digitoxin; Drug Intera | 1975 |
Inhibition of phenytoin metabolism by other drugs used in epilepsy.
Topics: Adult; Aged; Chloramphenicol; Chlorpromazine; Depression, Chemical; Drug Interactions; Epilepsy; Hal | 1975 |
[Epilepsy--seizures are preventable].
Topics: Adult; Birth Injuries; Brain Damage, Chronic; Brain Injuries; Brain Neoplasms; Child; Epilepsy; Fema | 1979 |
Diphenylhydantoin and pulmonary function.
Topics: Adolescent; Adult; Epilepsy; Female; Humans; Male; Phenytoin; Respiration; Respiratory Function Test | 1979 |
Dilantin and its relation to caries incidence.
Topics: Adolescent; Adult; Dental Caries; Dental Health Surveys; DMF Index; Epilepsy; Female; Humans; Male; | 1977 |
Diphenylhydantoinate-induced hyperplasia of the masticatory mucosa in an edentulous epileptic patient.
Topics: Adult; Denture, Complete; Diagnosis, Differential; Epilepsy; Gingival Hyperplasia; Humans; Male; Mou | 1978 |
Interrelationships between serum 25-hydroxycholecalciferol, serum parathyroid hormone and morphometric bone changes in anticonvulsant osteomalacia. Therapeutic effect of vitamin D2.
Topics: Bone and Bones; Epilepsy; Ergocalciferols; Humans; Hydroxycholecalciferols; Ileum; Osteomalacia; Par | 1977 |
Lymphocytotoxins in epileptic patients receiving phenytoin.
Topics: Antibodies; Antibodies, Antinuclear; Epilepsy; Humans; Immunoglobulin M; Lupus Erythematosus, System | 1977 |
Metabolism of immunoglobulin A, lymphocyte function, and histocompatibility antigens in patients on anticonvulsants.
Topics: Adolescent; Adult; Aged; Blood Proteins; Epilepsy; Female; Folic Acid; HLA Antigens; Humans; Immunol | 1978 |
Antipyretic analgesics in patients on antiepileptic drug therapy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Carbamazepine; Drug Interactions; Epilepsy; Female; | 1979 |
Measurement of the normal ventricular system and supratentorial subarachnoid space in children with computed tomography.
Topics: Adolescent; Age Factors; Anesthesia, General; Cerebral Ventricles; Cerebral Ventriculography; Child; | 1979 |
[Drug therapy of epilepsy].
Topics: Age Factors; Anticonvulsants; Barbiturates; Benzodiazepines; Bromides; Carbamazepine; Chlormethiazol | 1977 |
Drug interactions during anticonvulsant therapy in childhood: diphenylhydantoin, primidone, phenobarbitone, clonazepam, nitrazepam, carbamazepin and dipropylacetate.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Interactions; | 1977 |
Management of childhood epilepsy.
Topics: Child; Epilepsy; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1977 |
Implications of measuring anticonvulsant blood levels in epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Epilepsy; Humans; Middle Aged; Patient Compliance; | 1977 |
Preliminary observations on valproic acid kinetics in patients with epilepsy.
Topics: Adult; Child; Chromatography, Gas; Epilepsy; Humans; Phenobarbital; Phenytoin; Valerates; Valproic A | 1977 |
High-pressure liquid chromatography and enzyme immunoassay compared with gas chromatography for determing phenytoin.
Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Costs and Cost Analysis; Epilepsy; Humans | 1977 |
Deposits of plasma proteins in the skin during treatment with carbamazepine and diphenylhydantoin.
Topics: Adult; Aged; Blood Proteins; Carbamazepine; Epilepsy; Female; Fluorescent Antibody Technique; Humans | 1977 |
Epilepsy and IgA deficiency--the effect of sodium valproate.
Topics: Adult; Agammaglobulinemia; Carbamazepine; Epilepsy; Female; Humans; Immunoglobulin A; Male; Phenobar | 1977 |
Choice of drug therapy in epilepsy.
Topics: Acetazolamide; Anticonvulsants; Benzodiazepines; Carbamazepine; Clonazepam; Epilepsy; Ethosuximide; | 1977 |
[Plasma levels of anticonvulsants. Experiences with routine plasma level determination of 6 different anticonvulsants].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Ethos | 1978 |
Serum protein binding of diphenylhydantoin in man. I. Interaction with sodium valproate.
Topics: Drug Interactions; Epilepsy; Humans; In Vitro Techniques; Phenytoin; Protein Binding; Valerates; Val | 1978 |
Long-term use of the major anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximi | 1978 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; | 1979 |
Recent advances in drug therapy for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Drug Interactions; Epilepsy; Humans; Phenobarbital; Phen | 1979 |
The use of antiepileptic drugs.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximide; Humans; | 1979 |
Comparative trial of valproate sodium and clonazepam in chronic epilepsy.
Topics: Adult; Ataxia; Benzodiazepinones; Chronic Disease; Clonazepam; Drug Therapy, Combination; Epilepsy; | 1979 |
Serum protein binding of diphenylhydantoin in man. II. Interaction with sodium valproate in epileptic patients.
Topics: Adult; Binding, Competitive; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Phenyto | 1979 |
Decreased plasma protein binding of phenytoin in patients on valproic acid.
Topics: Adolescent; Adult; Blood Proteins; Child; Creatinine; Depression, Chemical; Epilepsy; Humans; Phenyt | 1979 |
[Changes in the thyroid hormone system with combined anticonvulsion treatment of epileptic children and adolescents (author's transl)].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Cholesterol; Drug Therapy, Combination; Enzyme In | 1977 |
Haemopexin, caeruloplasmin and C3: effect of diphenylhydantion.
Topics: Adolescent; Age Factors; Ceruloplasmin; Child; Child, Preschool; Complement C3; Complement System Pr | 1977 |
[Anticonvulsants and simultaneous medication - a problem in pregnancy (author's transl)].
Topics: Adult; Anticonvulsants; Antiemetics; Dihydroergotamine; Drug Combinations; Drug Interactions; Drug T | 1977 |
Medical treatment of epilepsy: part I.
Topics: Anticonvulsants; Bromides; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combina | 1978 |
Medical treatment of epilepsy: Part II.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Calcium; Child; Drug Interactions; Epilepsy; Ep | 1978 |
Anticonvulsant therapy. Approaches to some common clinical problems.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Eth | 1979 |
Epilepsy among parents of children with facial clefts.
Topics: Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Male; Parents; Phenobarbital; Ph | 1979 |
Epilepsy and pregnancy. Serum thyroxine levels during phenytoin therapy.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Epilepsy; Female; Fetus; Humans; Infant, Newborn; | 1979 |
Metabolism of diphenylhydantoin (phenytoin) during pregnancy.
Topics: Adolescent; Adult; Epilepsy; Female; Humans; Phenytoin; Postpartum Period; Pregnancy; Pregnancy Comp | 1979 |
Childhood cancer and drugs in pregnancy.
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Fetus; Humans; Infant; Infant, Newborn | 1979 |
Biochemical variables related to calcium metabolism in epileptics.
Topics: Aged; Alkaline Phosphatase; Anticonvulsants; Calcium; Carbamazepine; Epilepsy; Female; Humans; Male; | 1979 |
One drug for epilepsy [proceedings].
Topics: Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin | 1979 |
Cerebellar stimulation: regional effects on a thalamocortical system.
Topics: Animals; Cats; Cerebellum; Electric Stimulation; Epilepsy; Evoked Potentials; Phenytoin; Thalamus | 1979 |
Serum phenytoin, phenobarbital, carbamazepine, albumin; and plasma estradiol, progesterone concentrations during the menstrual cycle in women with epilepsy.
Topics: Adult; Carbamazepine; Epilepsy; Estradiol; Female; Humans; Menstruation; Phenobarbital; Phenytoin; P | 1979 |
Schizophrenia-like psychosis associated with anticonvulsant toxicity.
Topics: Adult; Anticonvulsants; Athetosis; Carbamazepine; Chorea; Dose-Response Relationship, Drug; Drug The | 1979 |
[Dynamics of serum hydantoinate levels following single intravenous administration and simultaneous electroencephalographic changes].
Topics: Adult; Brain; Child; Electroencephalography; Epilepsy; Female; Humans; Injections, Intravenous; Male | 1979 |
Transient hyperkinesia after a single intravenous perfusion of diphenylhydantoin. Report of a case associated with nontoxic plasma levels of diphenylhydantoin.
Topics: Adolescent; Epilepsy; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Hyperkinesis; Infusions, | 1979 |
[Drug therapy of epilepsy with control of the serum level of anti-epileptic agents].
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; | 1979 |
Drugs for epilepsy.
Topics: Carbamazepine; Epilepsy; Humans; Phenytoin | 1979 |
Drugs for epilepsy.
Topics: Drug Therapy, Combination; Epilepsy; Humans; Male; Phenytoin | 1979 |
Epilepsy and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Coagulation Disorders; Chromosome Aberrations; C | 1979 |
Chronic diphenyl hydantoin encephalopathy in mentally retarded children and adolescent with severe epilepsy.
Topics: Adolescent; Adult; Brain Diseases; Child; Child, Preschool; Chronic Disease; Epilepsy; Female; Human | 1979 |
Changes in serum triglyceride and cholesterol levels during long-term phenytoin treatment for epilepsy.
Topics: Adolescent; Adult; Cholesterol; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Time Factors | 1979 |
Phenytoin ("dilantin") and fits.
Topics: Epilepsy; Humans; Phenytoin | 1979 |
[Transient lowering of the IgA level during Diphedan therapy].
Topics: Child; Child, Preschool; Epilepsy; Female; Humans; Immunoglobulin A; Male; Phenytoin | 1979 |
Interaction between plasma phenytoin and phenobarbital concentrations in epileptic patients.
Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Phenobarbital; Phenytoin | 1979 |
Serum levels of phenytoin and phenobarbital in epileptic patients treated with mixture antiepileptic tablets, Comital-L or Hydantol-F.
Topics: Anticonvulsants; Drug Combinations; Epilepsy; Humans; Mephobarbital; Phenobarbital; Phenytoin | 1979 |
Effect of anticonvulsants on experimental cortical epilepsy induced by tungstic acid gel in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Electrocardiography; Electroencephalography; Epilepsy; F | 1979 |
[Quantitative analysis of EEG basic rhythms in epileptics (author's transl)].
Topics: Adult; Alpha Rhythm; Delta Rhythm; Electroencephalography; Epilepsy; Female; Humans; Male; Middle Ag | 1979 |
Problems in counseling the epileptic mother.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Barbiturates; Epilepsy; Female; Genetic Counseling; | 1979 |
Immunoglobulin G in serum and cerebrospinal fluid from epileptic patients treated with phenytoin.
Topics: Adolescent; Adult; Aged; Epilepsy; Female; Humans; Immunoglobulin A; Immunoglobulin G; Male; Middle | 1979 |
Effectiveness of simplified dosage schedules on the management of ambulant epileptic patients.
Topics: Adolescent; Adult; Ambulatory Care; Drug Administration Schedule; Epilepsy; Female; Humans; Male; Mi | 1979 |
[Fetal hydantoin syndrome (side effects of hydantoin preparations)].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Fetal Diseases; Fetus; Humans; Infant, Newborn; Male; | 1979 |
[Studies on the serum levels of the antiepileptic drugs-with particular reference to diphenylhydantoin, phenobarbital and carbamazepine-(author's transl)].
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsy; Humans; Middle Aged; Phenobarbi | 1979 |
The [14C]-aminopyrine breath test. A comparison of different forms of analysis.
Topics: Aminopyrine; Breath Tests; Carbon Dioxide; Epilepsy; Glucaric Acid; Glutethimide; Humans; Liver Dise | 1979 |
[Peripheral nerve function in patients with long-term anticonvulsant therapy (author's transl)].
Topics: Adolescent; Adult; Epilepsy; Female; Humans; Male; Middle Aged; Neural Conduction; Peripheral Nerves | 1979 |
[Diphenylhydantoin stimulation test in Wilson's disease].
Topics: Adult; Ceruloplasmin; Epilepsy; Female; Hepatolenticular Degeneration; Humans; Male; Middle Aged; Ph | 1979 |
Antiopyrine half-life as a measure of hepatic enzyme induction: clinical applications in a chronic epileptic population.
Topics: Adult; Antipyrine; Barbiturates; Enzyme Induction; Epilepsy; Female; Half-Life; Humans; Male; Micros | 1979 |
The epoxide of carbamazepine.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Biotransformation; Carbamazepine; Child; Child, Preschool; | 1979 |
Problems with the use of conventional anticonvulsant drugs in mentally retarded individuals.
Topics: Adolescent; Child; Child Behavior Disorders; Child, Preschool; Cognition; Epilepsy; Humans; Intellec | 1979 |
Effects of subjects' sex, and intake of tobacco, alcohol and oral contraceptives on plasma phenytoin levels.
Topics: Adolescent; Adult; Aged; Alcohol Drinking; Analysis of Variance; Child; Child, Preschool; Contracept | 1979 |
Effect of increased bioavailability of phenytoin tablets on serum phenytoin concentration in epileptic out-patients.
Topics: Biological Availability; Dose-Response Relationship, Drug; Epilepsy; Humans; Phenytoin; Tablets | 1979 |
The effect of salicylate on phenytoin pharmacokinetics.
Topics: Aspirin; Drug Interactions; Epilepsy; Humans; Phenytoin | 1979 |
Decreased phenytoin levels in antineoplastic therapy.
Topics: Adult; Antineoplastic Agents; Drug Interactions; Epilepsy; Humans; Intestinal Absorption; Male; Moni | 1979 |
Effect of influenza vaccination on plasma phenytoin concentrations.
Topics: Epilepsy; Humans; Influenza Vaccines; Metabolic Clearance Rate; Phenytoin; Vaccination | 1979 |
Predicting phenytoin dose - a revised nomogram.
Topics: Adolescent; Adult; Aged; Child; Epilepsy; Humans; Kinetics; Middle Aged; Phenytoin | 1979 |
Plasma anticonvulsant concentrations during pregnancy.
Topics: Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications | 1977 |
Induction of sex hormone binding globulin by phenytoin.
Topics: Adult; Epilepsy; Female; Humans; Phenytoin; Sex Hormone-Binding Globulin | 1977 |
The fetal hydantoin syndrome. A case report.
Topics: Abnormalities, Drug-Induced; Adult; Epilepsy; Female; Fetus; Humans; Hydantoins; Infant; Male; Pheny | 1978 |
Controversies in the treatment of febrile convulsions.
Topics: Child; Epilepsy; Humans; Intelligence; Phenobarbital; Phenytoin; Prognosis; Seizures; Seizures, Febr | 1979 |
The interrelationships between serum 25-hydroxycholecalciferol, serum parathyroid hormone and bone changes in anticonvulsant osteomalacia.
Topics: Adolescent; Adult; Binding, Competitive; Calcium, Dietary; Epilepsy; Feeding Behavior; Female; Human | 1977 |
Malignant mesenchymoma and birth defects. Prenatal exposure to phenytoin.
Topics: Adolescent; Adult; Cleft Lip; Cleft Palate; Epilepsy; Female; Follow-Up Studies; Humans; Male; Mater | 1977 |
Removal of phenytoin by hemodialysis in uremic patients.
Topics: Adolescent; Adult; Epilepsy; Female; Half-Life; Humans; Male; Middle Aged; Phenytoin; Plasma; Renal | 1977 |
[Methsuximide in the treatment of epilepsies (author's transl)].
Topics: Adolescent; Adult; Child; Drug Evaluation; Drug Interactions; Epilepsy; Gastrointestinal Diseases; H | 1977 |
Bioavailability of three phenytoin preparations in healthy subjects and in epileptics.
Topics: Adult; Biological Availability; Body Surface Area; Epilepsy; Female; Humans; Male; Phenytoin; Tablet | 1977 |
A case of musicogenic epilepsy.
Topics: Aged; Diazoxide; Electroencephalography; Epilepsy; Female; Humans; Music; Phenytoin | 1977 |
Phenytoin, phenobarbitone and serum cholesterol.
Topics: Adolescent; Adult; Cholesterol; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoi | 1977 |
[Consequeces of the elimination of a combination drug. Transition from combination antisacer: attention].
Topics: Adult; Drug Combinations; Epilepsy; Humans; Phenobarbital; Phenytoin | 1977 |
[Epilepsy and contraception].
Topics: Contraceptives, Oral; Contraceptives, Oral, Hormonal; Drug Interactions; Epilepsy; Female; Humans; O | 1977 |
Multiple drug interactions with phenytoin.
Topics: Alcoholism; Disulfiram; Epilepsy; Female; Humans; Middle Aged; Phenytoin; Substance Withdrawal Syndr | 1977 |
A teratological evaluation of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anencephaly; Anticonvulsants; Cleft Lip; Cleft Palate; Diazepam; Epilep | 1977 |
The effects of toxic and non-toxic serum phenytoin levels on carbohydrate tolerance and insulin levels.
Topics: Adolescent; Adult; Aged; Blood Glucose; Carbohydrate Metabolism; Child; Epilepsy; Female; Glucose To | 1977 |
Serum protein binding of diphenylhydantoin in healthy man.
Topics: Blood Proteins; Epilepsy; Female; Humans; Male; Phenytoin; Protein Binding; Temperature | 1977 |
[Chromosomal in study patients treated with anticonvulsant drugs].
Topics: Adolescent; Adult; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human | 1977 |
Stabilization of the thalamocortical motor system by cerebellar stimulation.
Topics: Animals; Cats; Cerebellar Cortex; Electric Stimulation; Electroencephalography; Epilepsy; Evoked Pot | 1977 |
Phenytoin-related cerebellar degeneration without seizures.
Topics: Cerebellum; Epilepsy; Female; Gliosis; Humans; Isoniazid; Middle Aged; Nerve Degeneration; Neuroglia | 1977 |
Conjugate lateral gaze nystagmus and free phenytoin concentrations in plasma: lack of correlation.
Topics: Adolescent; Adult; Aged; Electrooculography; Epilepsy; Female; Humans; Male; Middle Aged; Nystagmus, | 1978 |
Acute and chronic antiepileptic drug effect on the T complex interhemispheric latency difference.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Auditory Pathways; Brain; Child; Clonazepam; Electroenceph | 1978 |
[Phenytoin side effects. A study of children and young people with severe epilepsy].
Topics: Adolescent; Adult; Brain Diseases; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Phenytoi | 1978 |
Simultaneous gas liquid chromatographic dosage of phenobarbital and diphenylhydantoin in serum.
Topics: Chromatography, Gas; Epilepsy; Humans; Phenobarbital; Phenytoin | 1978 |
Electroencephalography and phenytoin toxicity in mentally retarded epileptic patients.
Topics: Adolescent; Adult; Brain; Child; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; | 1978 |
One drug for epilepsy.
Topics: Drug Therapy, Combination; Epilepsy; Humans; Phenytoin | 1978 |
[Do antiepileptics have a teratogenic effect?].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Congenital Abnormalities; Epilepsy; Female; Humans; In | 1978 |
The effects of dose, age, and sex on the serum levels of phenobarbital and diphenylhydantoin in epileptic patients.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Epilepsy; Female; Humans; Kinetics; M | 1978 |
[Optimizing the therapeutic process in long-term antiepileptic therapy through the determination of drug levels in patients].
Topics: Anticonvulsants; Carbamazepine; Drug Therapy; Epilepsy; Ethosuximide; Germany, East; Humans; Methods | 1978 |
[Toxic "atrophie cerebelleuse". (problems associated with permanent cerebellar damage due to chronic diphenylhydantion intoxication)].
Topics: Adult; Atrophy; Brain Damage, Chronic; Cerebellar Diseases; Epilepsy; Female; Humans; Phenytoin; Rad | 1978 |
[Determination of serum levels of phenobarbital and diphenylhydantoin in the treatment of epilepsy].
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Humans; Middle Aged; Phenobarbital; Phen | 1978 |
Soft neurological correlates of compulsive eaters.
Topics: Adolescent; Adult; Child; Compulsive Behavior; Eating; Electroencephalography; Epilepsy; Female; Hum | 1978 |
Hematologic effects of phenytoin therapy during pregnancy.
Topics: Carotenoids; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Hematologic Tests; Humans; Phenyto | 1978 |
[Calcium and phospate metabolism disorders in patients on long-term diphenylhydantoin therapy].
Topics: Adolescent; Adult; Bone and Bones; Calcium; Epilepsy; Humans; Hypocalcemia; Magnesium; Middle Aged; | 1978 |
Compliance with anticonvulsant therapy in a hospital clinic and in the community.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Drug Prescriptions; Epilepsy; Female; Humans; Male; | 1978 |
[Phenytoin determination in blood in epileptic children].
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Phenytoin; Protein Binding; Tim | 1978 |
Individual variation in daily dosage requirements for phenytoin sodium in patients with epilepsy.
Topics: Adult; Age Factors; Body Weight; Drug Administration Schedule; Epilepsy; Female; Glucaric Acid; Huma | 1978 |
Drug compliance and therapeutic considerations in 75 black epileptic children.
Topics: Adolescent; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Ma | 1978 |
School-children with epilepsy at risk for learning and behaviour problems.
Topics: Achievement; Attention; Child; Child Behavior Disorders; Cognition; Dependency, Psychological; Epile | 1978 |
Effect of anticonvulsant therapy on serum 25-hydroxyvitamin D level.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Humans; H | 1978 |
[Antiepileptic emergency therapy in the adult age].
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Diazepam; Emergencies; Epilepsy; Humans; Phenobarbi | 1978 |
Kinetics of drug interactions in the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Ethanol; Female; Humans; Kinet | 1978 |
[Phenytoin intoxication and serum level].
Topics: Adolescent; Adult; Aged; Ataxia; Athetosis; Attention; Child; Child, Preschool; Chorea; Dose-Respons | 1978 |
Abdominal epilepsy. A cause of abdominal pain in adults.
Topics: Abdomen; Adolescent; Adult; Diagnosis, Differential; Electroencephalography; Epilepsy; Female; Human | 1978 |
Fetal hydantoin syndrome in triplets. A unique experiment of nature.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Epilepsy; Face; Female; Growth Disorder | 1978 |
Congenital malformations and seizure disorders in the offspring of parents with epilepsy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Barbiturates; Child; Child, Preschool; Congenital Ab | 1978 |
[Blood levels of phenytoin and phenobarbital in epileptics treated with phenydantin and phenytoinum].
Topics: Drug Synergism; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phenytoin | 1978 |
[Change of diphenylhydantoin tolerance at the time of reaching puberty in a 16-year-old girl suffering from epilepsy].
Topics: Adolescent; Drug Tolerance; Epilepsy; Female; Humans; Meniere Disease; Nystagmus, Pathologic; Phenyt | 1978 |
Action of anticonvulsants on pentylenetetrazol-induced epileptiform activity on invertebrate neurones (Helix aspersa).
Topics: Action Potentials; Amobarbital; Animals; Anticonvulsants; Diazepam; Epilepsy; Helix, Snails; In Vitr | 1978 |
[Severe cerebellar lesions caused by diphenylhydantoin--a contribution to the problem of hydantoin poisoning].
Topics: Adolescent; Ataxia; Dietary Proteins; Dysarthria; Encephalitis; Epilepsy; Female; Humans; Nystagmus, | 1978 |
Brain concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic patients.
Topics: Adolescent; Brain; Carbamazepine; Child; Epilepsy; Epoxy Compounds; Female; Humans; Male; Phenobarbi | 1978 |
Comparison of serum phenytoin levels in epileptic patients who swallowed their phenytoin tablets with or without previous chewing.
Topics: Epilepsy; Humans; Phenytoin; Solubility; Tablets; Time Factors | 1978 |
Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.
Topics: Epilepsy; Humans; Male; Middle Aged; Multiple Myeloma; Phenytoin | 1978 |
Preliminary report on the magnesium deficient rat as a model of epilepsy.
Topics: Age Factors; Animals; Disease Models, Animal; Epilepsy; Female; Magnesium Deficiency; Male; Phenobar | 1978 |
[Measurement of the blood concentration of antiepileptic drugs. II Special cases].
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Epilepsy; Ethosuximide; Humans; Phenobarbi | 1975 |
Correlation between red cell and free plasma phenytoin levels in renal disease.
Topics: Adult; Aged; Epilepsy; Erythrocytes; Female; Humans; Kidney Diseases; Kidney Transplantation; Male; | 1976 |
Proposals on antiepileptic pharmacotherapy for use in developing countries.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Developing Countries; Diazepam | 1976 |
Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy.
Topics: Acetazolamide; Adolescent; Age Factors; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy | 1975 |
Findings in routine laboratory examination in progressive myoclonus epilepsy.
Topics: Adolescent; Adult; Age Factors; Blood Glucose; Blood Proteins; Cerebrospinal Fluid Proteins; Child; | 1975 |
Criteria for selection of patients for neurosurgical treatment.
Topics: Adolescent; Age Factors; Child; Electroencephalography; Encephalitis; Epilepsies, Partial; Epilepsy; | 1975 |
Thickening of the heel-pad associated with long-term Dilantin therapy.
Topics: Anthropometry; Connective Tissue; Epilepsy; Female; Foot Diseases; Heel; Humans; Long-Term Care; Mal | 1975 |
Systematic determination of the serum phenytoin level as an aid in the management of children with epilepsy.
Topics: Acetazolamide; Adolescent; Carbamazepine; Child; Child, Preschool; Contraceptives, Oral; Drug Intera | 1975 |
Seizures in adolescents.
Topics: Adolescent; Anticonvulsants; Automobile Driving; Benzodiazepines; Carbamazepine; Diagnosis, Differen | 1975 |
Diseases of the central nervous system: Epilepsy.
Topics: Age Factors; Diazepam; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Eth | 1975 |
Sensible prescribing. XI.--Juvenile and adult epilepsy.
Topics: Adolescent; Adult; Age Factors; Carbamazepine; Child; Clonazepam; Epilepsy; Epilepsy, Absence; Epile | 1975 |
Effects of different dosages of anticonvulsant drugs on mental performance in patients with chronic epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Chronic Disease; Dose-Response Relationship, Drug; Epilep | 1975 |
The effect of oral physiotherapy on dilantin gingival hyperplasia.
Topics: Adolescent; Epilepsy; Gingival Crevicular Fluid; Gingival Hyperplasia; Gingivectomy; Gingivitis; Hum | 1976 |
Epilepsy: a controllable disease. Part 2. Drug therapy and nursing care.
Topics: Acute Disease; Adolescent; Anticonvulsants; Child; Epilepsy; Ethosuximide; Gingival Hyperplasia; Hum | 1976 |
Phenytoin and phenobarbitone plasma clearance during pregnancy.
Topics: Adult; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; Human | 1976 |
Sodium valproate in the treatment of resistant epilepsy.
Topics: Adolescent; Adult; Alopecia; Anticonvulsants; Body Weight; Diarrhea; Drug Interactions; Epilepsies, | 1976 |
Epilepsy and other seizure disorders in children: drug management.
Topics: Acetazolamide; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, T | 1976 |
Behavioral management of epileptic seizures following EEG biofeedback training of the sensorimotor rhythm.
Topics: Action Potentials; Adolescent; Adult; Biofeedback, Psychology; Dose-Response Relationship, Drug; Ele | 1976 |
Interactions of phenytoin and phenobarbital in terms of order and temporal spacing of administration in monkeys.
Topics: Animals; Drug Interactions; Epilepsy; Half-Life; Haplorhini; Macaca mulatta; Male; Phenobarbital; Ph | 1976 |
Salivary phenytoin radioimmunoassay. A simple method of the assessment of non-protein bound drug concentrations.
Topics: Adult; Blood Proteins; Epilepsy; Half-Life; Humans; Phenytoin; Protein Binding; Radioimmunoassay; Sa | 1977 |
Immunoglobulin levels and autoantibodies in epileptics on long-term anticonvulsant therapy.
Topics: Adolescent; Adult; Anticonvulsants; Autoantibodies; Epilepsy; Female; Humans; Immunoglobulin A; Immu | 1977 |
Athetosis and phenytoin toxicity.
Topics: Athetosis; Epilepsy; Humans; Infant; Male; Phenytoin | 1977 |
Techniques for demonstration of the specificity of circulating anticoagulants against antihemophilic factor (factor VIII), with studies of two cases possibly related to diphenylhydantoin therapy.
Topics: Adult; Anticoagulants; Blood Coagulation Tests; Epilepsy; Factor VIII; Humans; Immunoglobulins; Male | 1977 |
Individualization of phenytoin dosage regimens.
Topics: Adolescent; Adult; Drug Administration Schedule; Epilepsy; Female; Humans; Kinetics; Male; Middle Ag | 1977 |
Plasma concentrations of 5-(4-hydroxyphenyl)-5-phenylhydantoin in phenytoin-treated patients.
Topics: Dose-Response Relationship, Drug; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylat | 1977 |
Long-term of phenytoin: Effects on whole blood and red cell folate and haematological parameters.
Topics: Adolescent; Adult; Anemia, Megaloblastic; Child; Child, Preschool; Epilepsy; Erythrocyte Count; Eryt | 1977 |
Menstrual epileptoid psychosis in an adolescent girl.
Topics: Adolescent; Catatonia; Epilepsy; Female; Humans; Menstruation; Neurocognitive Disorders; Phenytoin | 1977 |
[Plasma concentrations after injection or infusion of phenytoin (author's transl)].
Topics: Adult; Arrhythmias, Cardiac; Epilepsy; Female; Humans; Infusions, Parenteral; Injections, Intravenou | 1977 |
Phenytoin-induced pseudolymphoma syndrome: an immunologic study.
Topics: Adult; Antibody Formation; Drug Hypersensitivity; Epilepsy; Female; Humans; Hypersensitivity, Delaye | 1977 |
[Liver damage after long-term administration of phenylethylbarbituric acid and diphenylhydantoin].
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Humans; Leucy | 1977 |
Plasma levels of phenobarbital and phenytoin in epileptic outpatients.
Topics: Adolescent; Adult; Ambulatory Care; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Human | 1977 |
Serum levels of anticonvulsants and haematological sequelae in black epileptics.
Topics: Adolescent; Adult; Aged; Black People; Child; Child, Preschool; Drug Combinations; Epilepsy; Erythro | 1977 |
[Symptomatic treatment of epilepsy].
Topics: Anticonvulsants; Diazepam; Epilepsy; Humans; Phenobarbital; Phenytoin | 1977 |
[Serum phenytoin determination, its value in the treatment of epilepsy].
Topics: Epilepsy; Humans; Phenytoin; Seizures | 1977 |
[Poisoning by small doses of diphenylhydantoin].
Topics: Administration, Oral; Aged; Drug Combinations; Epilepsy; Humans; Male; Phenytoin; Poisoning | 1977 |
Evidence of osteomalacia in an outpatient group of adult epileptics.
Topics: Adult; Aged; Diet; Epilepsy; Female; Humans; Male; Middle Aged; Osteomalacia; Phenobarbital; Phenyto | 1977 |
Chromosome studies of bone marrow cells and peripheral blood lymphocytes from diphenylhydantoin-treated patients.
Topics: Adult; Bone Marrow; Bone Marrow Cells; Cell Nucleus; Chromosomes; Epilepsy; Female; Humans; Lymphocy | 1977 |
Plasma protein binding of phenytoin after cholecystectomy and neurosurgical operations.
Topics: Adolescent; Adult; Blood Proteins; Cholecystectomy; Epilepsy; Female; Humans; Intracranial Aneurysm; | 1977 |
Lack of effect of clonazepam on serum levels of diphenylhydantoin, phenobarbital and carbamazepine.
Topics: Adolescent; Adult; Benzodiazepinones; Carbamazepine; Child; Clonazepam; Drug Interactions; Drug Ther | 1977 |
The effect of anticonvulsant drugs which induce liver microsomal enzymes on derived and ingested phenobarbitone levels.
Topics: Adolescent; Adult; Biotransformation; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Fem | 1977 |
Acetazolamide-accelerated anticonvulsant osteomalacia.
Topics: Acetazolamide; Adult; Anticonvulsants; Calcium; Epilepsy; Female; Humans; Mephobarbital; Osteomalaci | 1977 |
The investigation of phenobarbitone, phenytoin and primidone in the death of epileptics.
Topics: Epilepsy; Forensic Medicine; Humans; Phenobarbital; Phenytoin; Primidone | 1977 |
[Biotransformation and its modification by barbiturates].
Topics: Binding Sites; Biotransformation; Drug Interactions; Enzyme Induction; Epilepsy; Humans; Liver; Live | 1977 |
[The anti-epileptic drugs].
Topics: Age Factors; Anticonvulsants; Carbamazepine; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoi | 1977 |
Cerebellar atrophy in phenytoin-treated mentally retarded epileptics.
Topics: Adolescent; Adult; Atrophy; Cerebellum; Child; Child, Preschool; Epilepsy; Female; Humans; Intellect | 1977 |
Epilepsy.
Topics: Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phenytoin | 1977 |
Evaluation of serum levels during prolonged combination therapy with phenytoin and phenobarbitone.
Topics: Adult; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Middle Aged; Phenobarbital; P | 1977 |
Phenytoin dosage in the elderly.
Topics: Age Factors; Aged; Epilepsy; Female; Humans; Male; Phenytoin | 1977 |
[Status epilepticus in Lennox-Gastaut syndrome; therapeutic aspects].
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Child; Child, Preschool; Electroencephalography; Epi | 1977 |
Interaction between phenytoin and imipramine.
Topics: Adult; Depression; Drug Interactions; Epilepsy; Humans; Imipramine; Phenytoin; Time Factors | 1977 |
Distribution of plasma phenobarbital, diphenylhydantoin and primidone levels in epileptic patients.
Topics: Adult; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Primidone | 1977 |
[Diphenylhydantoin inducing a lupus erythematosus-like syndrome].
Topics: Adult; Diagnosis, Differential; Epilepsy; Female; Humans; Lupus Erythematosus, Systemic; Male; Middl | 1977 |
Pharmacokinetics of phenytoin following intravenous administration in epileptic patients.
Topics: Adult; Epilepsy; Humans; Injections, Intravenous; Kinetics; Male; Phenytoin | 1977 |
Hydantoin ring glucuronidation: characterization of a new metabolite of 5,5-diphenylhydantoin in man and the rat.
Topics: Animals; Bile; Chemical Phenomena; Chemistry; Epilepsy; Glucuronates; Humans; Ions; Liver; Male; Mas | 1977 |
Incidence of fracture in epileptics.
Topics: Adult; Age Factors; Aged; Epilepsy; Female; Fractures, Bone; Humans; Male; Middle Aged; Osteomalacia | 1977 |
Comparison of six procedures for the simultaneous determination of antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Epilepsy; Humans; Phenobarbital; Phenytoin; Pri | 1977 |
[Determination of blood level of diphenylhydantoin in the treatment of epilepsy. The need for monitoring].
Topics: Biological Availability; Epilepsy; Female; Humans; Male; Methods; Phenytoin | 1977 |
Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants.
Topics: Adult; Anticonvulsants; Dupuytren Contracture; Epilepsy; Female; Humans; Male; Middle Aged; Phenobar | 1976 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio | 1976 |
Letter: Diazoxide-diphenylhydantoin interaction.
Topics: Child, Preschool; Diazoxide; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Hypogly | 1976 |
Phenytoin-induced dystonia and choreoathetosis in two retarded epileptic children.
Topics: Athetosis; Child; Chorea; Epilepsy; Humans; Intellectual Disability; Male; Muscular Diseases; Phenyt | 1976 |
Editorial: The control of anti-epileptic drug treatment.
Topics: Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin | 1976 |
[Brain stem seizures with circumscrbed elementary symptoms].
Topics: Adult; Amitriptyline; Ataxia; Brain Neoplasms; Brain Stem; Carbamazepine; Epilepsy; Female; Humans; | 1976 |
[A laboratory method for the control of diphenylhydantoin treatment (author's transl)].
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Phenytoin | 1976 |
Plasma levels of carbamazepine and carbamazepine-10,11-epoxide during treatment of epilepsy.
Topics: Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Epoxy Compounds; Humans; Phenytoin | 1976 |
Immunoglobulin abnormalities in epileptic patients treated with diphenylhydantoin.
Topics: Adolescent; Adult; Aged; Child; Dysgammaglobulinemia; Epilepsy; Female; Humans; Immunoglobulin A; Im | 1976 |
Ascorbic acid concentrations in human plasma and cerebrospinal fluid [proceedings].
Topics: Ascorbic Acid; Epilepsy; Humans; Phenobarbital; Phenytoin; Primidone | 1976 |
Clonazepam: a review of its pharmacological properties and therapeutic efficacy in epilepsy.
Topics: Absorption; Animals; Antitussive Agents; Benzodiazepinones; Brain; Cats; Clonazepam; Drug Interactio | 1976 |
Phenytoin-induced depression of salivary IgA and gingival hyperplasia.
Topics: Adolescent; Adult; Child; Depression, Chemical; Epilepsy; Gingival Hyperplasia; Humans; Immunoglobul | 1976 |
Serum calcium balance during early phase of diphenylhydantoin therapy.
Topics: Adolescent; Adult; Alkaline Phosphatase; Epilepsy; Female; Humans; Hydroxyproline; Hypocalcemia; Mal | 1976 |
Use of phenytoin serum levels in a case of status epilepticus.
Topics: Adult; Burns; Epilepsy; Female; Humans; Oxacillin; Phenytoin | 1976 |
Further observations on carbamazepine plasma levels in epileptic patients. Relationships with therapeutic and side effects.
Topics: Adult; Age Factors; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalography; Epileps | 1976 |
[Influencing of the thyroid hormone system by long-term treatment with 5-5 diphenylhydantion in children and adolescens (author's transl)].
Topics: Adolescent; Child; Epilepsy; Female; Humans; Hypothalamus; Iodine; Liver; Male; Phenytoin; Protein B | 1976 |
Death due to isoniazid (INH) and phenytoin.
Topics: Drug Interactions; Epilepsy; Female; Humans; Isoniazid; Middle Aged; Phenytoin; Tuberculosis, Lymph | 1976 |
Reduced CSF IgG in patients treated with phenytoin (diphenylhydantoin).
Topics: Adolescent; Adult; Cerebrospinal Fluid Proteins; Child, Preschool; Epilepsy; Humans; Immunoglobulin | 1976 |
A neuropathological case-study of myoclonus epilepsy.
Topics: Adult; Brain Diseases; Cysts; Epilepsy; Humans; Male; Myoclonus; Phenytoin | 1976 |
[Determination of plasma phenytoine and treatment of epileptics].
Topics: Alcoholism; Epilepsy; Female; Humans; Male; Patient Compliance; Phenytoin | 1976 |
Changes in serum immunoglobulin levels during phenytoin treatment of epilepsy.
Topics: Adolescent; Adult; Child; Depression, Chemical; Epilepsy; Erythrocytes; Female; Folic Acid; Humans; | 1976 |
Chromosomal damage in epileptics on monotherapy with carbamazepine and diphenylhydantoin.
Topics: Adolescent; Adult; Carbamazepine; Chromosome Aberrations; Chromosomes; Epilepsy; Female; Humans; Mal | 1976 |
[Current problems of phenytoin treatment (authors transl)].
Topics: Drug Interactions; Epilepsy; Humans; Phenytoin | 1976 |
Anticonvulsant drugs and mental symptoms: a review.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Folic Acid | 1976 |
[Toxic epidermal necrolosys -- Lyell's syndrome in a patient protractedly treated by anti-epileptic agents].
Topics: Adult; Anticonvulsants; Barbiturates; Epilepsy; Humans; Male; Mephenytoin; Phenobarbital; Phenytoin; | 1976 |
[Interval therapy of febrile convulsions for the management of their prognosis. I. Methods and therapeutic advice for interval therapy of febrile convulsions].
Topics: Child, Preschool; Epilepsy; Humans; Infant; Periodicity; Phenobarbital; Phenytoin; Recurrence; Seizu | 1976 |
[Psychotropic drugs for behavior disorder treatment in oligophrenic epileptics].
Topics: Adult; Epilepsy; Humans; Intellectual Disability; Methotrimeprazine; Phenytoin; Primidone; Promazine | 1976 |
The necessity of drug level monitoring in anticonvulsant drug therapy.
Topics: Body Weight; Dose-Response Relationship, Drug; Epilepsy; Humans; Patient Compliance; Phenobarbital; | 1976 |
[Pathological changes in the oral cavity and some problems of stomatological treatment of epileptics].
Topics: Epilepsy; Gingival Hypertrophy; Humans; Phenytoin | 1975 |
New uses for phenytoin.
Topics: Arrhythmias, Cardiac; Diabetic Neuropathies; Digitalis Glycosides; Drug Evaluation; Epilepsy; Gastro | 1975 |
[Prospects of surgical treatment in hydantoin-induced gingival hyperplasia].
Topics: Adolescent; Adult; Child; Epilepsy; Female; Gingival Hyperplasia; Gingivectomy; Humans; Hydantoins; | 1976 |
[Histopathology of gingival manifestations of hydantoin therapy].
Topics: Adolescent; Adult; Aged; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Gingiva; Gingiva | 1976 |
[Prosthetic treatment of periodontal disease in epileptics].
Topics: Epilepsy; Humans; Periodontal Diseases; Periodontal Prosthesis; Phenytoin | 1976 |
The excessively small ventricle on computed axial tomography of the brain.
Topics: Adolescent; Adult; Brain; Brain Concussion; Brain Diseases; Brain Neoplasms; Cerebral Ventriculograp | 1976 |
Letter: Sodium valproate in the treatment of intractable childhood epilepsy.
Topics: Diazepam; Drug Therapy, Combination; Epilepsy; Phenobarbital; Phenytoin; Primidone; Pyridoxine; Vale | 1975 |
Elevation of diphenylhydantoin and primidone serum concentration by addition of dipropylacetate, a new anticonvulsant drug.
Topics: Child; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Primidone; Valerat | 1975 |
Method for diphenylhydantoin and phenobarbital assay by gas chromatography.
Topics: Buffers; Chloroform; Chromatography, Gas; Chromatography, Thin Layer; Colorimetry; Epilepsy; Humans; | 1975 |
The adverse effect of anticonvulsant therapy on renal allograft survival. A preliminary report.
Topics: Adolescent; Anticonvulsants; Cadaver; Child; Child, Preschool; Epilepsy; Ethosuximide; Humans; Kidne | 1976 |
The influence of aldosterone and anticonvulsant drugs on electroencephalographic and clinical disturbances induced by the spirolactone derivative, potassium canrenoate.
Topics: Aldosterone; Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Dogs; Electroencepha | 1975 |
Letter: Epanutin and isoniazid interaction.
Topics: Adult; Carbamazepine; Drug Interactions; Electroencephalography; Epilepsy; Ethambutol; Ethosuximide; | 1975 |
Dermatology mediquiz. Case 5.
Topics: Adult; Diagnosis, Differential; Epilepsy; Female; Gingival Hypertrophy; Humans; Leukemia, Lymphoid; | 1975 |
Harmful effect of megadoses of vitamins: electroencephalogram abnormalities and seizures induced by intravenous folate in drug-treated epileptics.
Topics: Adolescent; Adult; Aged; Child; Electroencephalography; Epilepsy; Female; Folic Acid; Humans; Male; | 1975 |
Anaesthesia and the epileptic pateint. A review.
Topics: Adult; Anesthesia, General; Anticonvulsants; Barbiturates; Central Nervous System; Child, Preschool; | 1975 |
The freezing lesion. III. The effects of diphenylhydantoin on potassium transport within nerve terminals from the primary foci.
Topics: Animals; Cats; Cerebral Cortex; Electroencephalography; Electrophysiology; Epilepsy; Freezing; In Vi | 1975 |
Letter: Metric blood levels of diphenylhydantoin.
Topics: Epilepsy; Humans; Phenytoin | 1975 |
Letter: Plasma levels of antidepressants and anticonvulsants.
Topics: Epilepsy; Humans; Phenytoin | 1975 |
[Letter: Diphenylhydrantoin poisoning during disulfiram therapy].
Topics: Adult; Alcoholism; Biotransformation; Disulfiram; Enzyme Inhibitors; Epilepsy; Humans; Liver; Male; | 1975 |
Iatrogenic osteomalacia in epileptic children. A controlled therapeutic trial.
Topics: Bone and Bones; Calcium; Epilepsy; Osteomalacia; Phenytoin; Placebos; Radius; Stimulation, Chemical; | 1975 |
Letter; myocardial infarction in epileptics.
Topics: Epilepsy; Humans; Myocardial Infarction; Osteomalacia; Phenytoin; Vitamin D | 1975 |
[Dynamics of the serum level increase of hydantoins following the begin of oral administration].
Topics: Administration, Oral; Adult; Child; Epilepsy; Female; Humans; Male; Phenytoin; Time Factors | 1975 |
Dilantin-induced disseminated intravascular coagulation with purpura fulminans. A case report.
Topics: Adolescent; Blood Coagulation Tests; Disseminated Intravascular Coagulation; Epilepsy; Female; Hepar | 1975 |
Serum magnesium levles in patients treated with phenytoin.
Topics: Epilepsy; Humans; Magnesium; Phenytoin; Serum Albumin | 1975 |
Chlormethiazole in status epilepticus--three cases.
Topics: Adult; Chlormethiazole; Diazepam; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin | 1975 |
[Plasma concentration of phenytoin in epileptics--importance for the clinician].
Topics: Adult; Child; Chromatography, Gas; Dose-Response Relationship, Drug; Epilepsy; Humans; Medication Er | 1975 |
Delayed and insidious onset of diphenylhydantoin toxicity.
Topics: Adolescent; Adult; Animals; Cerebellar Ataxia; Drug Interactions; Electroencephalography; Epilepsy; | 1975 |
[Personality and sex behavior among epileptics during long term treatment with DPH].
Topics: Adolescent; Adult; Attitude; Epilepsy; Follicle Stimulating Hormone; Humans; Libido; Luteinizing Hor | 1975 |
[Anti epileptic therapy with diphenylhydantoin with serum controls in childhood. Clinical experiences].
Topics: Adolescent; Body Weight; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Phenytoin | 1975 |
[Determination of phenytoin in saliva and its clinical significance].
Topics: Adolescent; Adult; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Saliva | 1975 |
[Effects of anticonvulsive treatment on drug elimination in man. Induction of liver hydroxylating enzyme system by diphenylhydantoin and carbamazepine].
Topics: Adult; Antipyrine; Bilirubin; Carbamazepine; Creatinine; Epilepsy; Female; Half-Life; Humans; Hydrox | 1975 |
Diphenylhydantoin-induced gingival hyperplasia: its response to changes in drug dosage.
Topics: Adolescent; Adult; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Gingival Hyperplasia; | 1975 |
[Diphenylhydantoin poisoning].
Topics: Epilepsy; Humans; Phenytoin | 1975 |
The management of epilepsy.
Topics: Amobarbital; Anticonvulsants; Diazepam; Drug Therapy, Combination; Emergencies; Epilepsy; Humans; Ph | 1975 |
Maternal phenytoin ingestion and congenital abnormalities: report of a case.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anus, Imperforate; Bladder Exstrophy; E | 1975 |
A rapid gas-liquid chromatographic determination of serum levels of phenobarbital and diphenyllhydantoin.
Topics: Chromatography, Gas; Epilepsy; Humans; Microchemistry; Phenobarbital; Phenytoin | 1975 |
The value of serum diphenylhydantoin (phenytoin) levels in the management of epilepsy.
Topics: Child; Epilepsy; Humans; Mental Disorders; Phenytoin | 1975 |
Teratogenic effects of diphenylhydantoin.
Topics: Abnormalities, Drug-Induced; Adult; Breast; Epilepsy; Face; Female; Hernia, Inguinal; Hip Dislocatio | 1975 |
Cognitive and motor-sensory performances in toxic and nontoxic epileptic subjects.
Topics: Adult; Attention; Cognition; Epilepsy; Female; Humans; Intelligence Tests; Male; Motor Skills; Pheno | 1975 |
Congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord | 1975 |
Unexpected, unexplained death in epileptic patients.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Death, Sudden; Epilepsy; Female; Humans; Male; Mid | 1975 |
Photically induced epilepsy in Papio papio as a model for drug studies.
Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose- | 1975 |
Delayed idiosyncratic psychosis with diphenylhydantoin.
Topics: Adult; Epilepsy; Female; Humans; Paranoid Disorders; Phenytoin; Psychoses, Substance-Induced; Time F | 1975 |
Anticonvulsant drug blood levels.
Topics: Anticonvulsants; Ataxia; Diplopia; Drug Therapy, Combination; Epilepsy; Humans; Nystagmus, Pathologi | 1975 |
Letter: Reporting of anticonvulsant blood levels.
Topics: Epilepsy; Humans; Phenytoin | 1975 |
Status epilepticus.
Topics: Anesthesia, General; Anticonvulsants; Diazepam; Emergencies; Epilepsy; Humans; Injections, Intramusc | 1975 |
The gingival hyperplasia resulting from diphenylhydantoin in children and adults.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Gingiv | 1975 |
[Current viewpoints in drug treatment of epilepsy, with reference to the most common drugs in current use].
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin | 1975 |
Relationships among dose, serum and CSF levels and urinary output in fenobarbital and fenitoin treatment of epileptics.
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Middle Aged; Phe | 1975 |
Comparative study of proteins and lactic dehydrogenase isoenzymes in the blood and cerebrospinal fluid of nontreated and of phenobarbital and diphenylhydantoin treated epileptic patients.
Topics: Blood Proteins; Cerebrospinal Fluid Proteins; Epilepsy; Humans; Isoenzymes; L-Lactate Dehydrogenase; | 1975 |
Therapeutic response relationship to phenobarbital and diphenylhydantoin serum and cerebrospinal fluid levels in epileptics.
Topics: Adolescent; Adult; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Female; Huma | 1975 |
Phenytoin and phenobarbital concentrations in saliva and plasma measured by radioimmunoassay.
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Humans; Infant; Middle Aged; Phenobarbital; Ph | 1975 |
Diphenylhydantoin serum levels, toxicity, and neuropsychological performance in patients with epilepsy.
Topics: Adult; Blood-Brain Barrier; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Mental | 1975 |
The effect of anticonvulsant therapy on serum levels of 25-hydroxy-vitamin D, calcium, and parathyroid hormone.
Topics: Calcium; Cholesterol; Epilepsy; Female; Humans; Hyperparathyroidism, Secondary; Hypocalcemia; Parath | 1975 |
Folate and monoamine metabolism in epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Biogenic Amines; Epilepsy; Erythrocytes; Folic Acid; Homovanilli | 1975 |
Fluctuations of plasma phenytoin levels on single dose and twice daily dose regimes.
Topics: Adolescent; Adult; Child; Chronic Disease; Drug Administration Schedule; Epilepsy; Female; Humans; M | 1975 |
Hematologic toxicity of carbamazepine.
Topics: Adult; Aged; Anemia, Aplastic; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Female; Hu | 1975 |
Management of the difficult patient with complex partial seizures.
Topics: Adult; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epileps | 1975 |
Psychosocial management of patients with complex partial seizures.
Topics: Adult; Alcoholism; Carbamazepine; Delivery of Health Care; Drug Administration Schedule; Epilepsy; E | 1975 |
Epilepsy anticonvulsants and malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1975 |
Interaction of diphenylhydantoin (DPH) and tolbutamide in man.
Topics: Adult; Animals; Blood Proteins; Drug Interactions; Epilepsy; Female; Humans; In Vitro Techniques; Ma | 1975 |
Pharmacokinetics and side-effects of clonazepam and its 7-amino-metabolite in man.
Topics: Adolescent; Adult; Aged; Benzodiazepinones; Biotransformation; Child; Clonazepam; Drug Interactions; | 1975 |
Effect of age, height, weight and sex on serum phenytoin concentration in epileptic patients.
Topics: Adult; Age Factors; Aged; Body Height; Body Weight; Epilepsy; Female; Humans; Male; Middle Aged; Phe | 1975 |
Paroxysmal "nightmares". Sequel of a stroke responsive to diphenylhydantoin.
Topics: Aged; Dreams; Epilepsy; Humans; Male; Phenytoin; Sleep Wake Disorders | 1975 |
Plasma level studies on different brands of sodium diphenylhydantoin (DPH) and primidone.
Topics: Biological Availability; Capsules; Epilepsy; Female; Humans; Kinetics; Male; Phenobarbital; Phenytoi | 1975 |
[Problems in the use of anti-epileptics. 2. Resorption and the influence of resorption].
Topics: Animals; Anticonvulsants; Child; Epilepsy; Humans; Hydroxylation; Milk; Phenobarbital; Phenytoin; Po | 1975 |
Hydantoin derivatives and malignancies of the haemopoietic system.
Topics: Adult; Epilepsy; Hematopoietic System; Humans; Lymphoma, Non-Hodgkin; Male; Middle Aged; Phenytoin | 1975 |
Discrepancies in recommended dosage regimens of drugs.
Topics: Adult; Epilepsy; Humans; Phenobarbital; Phenytoin | 1976 |
Acute athetosis as a result of phenytoin toxicity in a child.
Topics: Athetosis; Child, Preschool; Epilepsy; Humans; Male; Phenytoin | 1976 |
Letter: Failure to confirm anticonvulsant hypomagnesaemia.
Topics: Epilepsy; Humans; Magnesium Deficiency; Phenobarbital; Phenytoin | 1976 |
Interaction of quinidine with anticonvulsant drugs.
Topics: Adult; Arrhythmias, Cardiac; Depression, Chemical; Drug Interactions; Enzyme Induction; Epilepsy; Fe | 1976 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; | 1976 |
[Drug induced IgA deficiency in epilepsy].
Topics: Adolescent; Adult; Child; Dysgammaglobulinemia; Epilepsy; Humans; Immunoglobulin A; Immunologic Defi | 1976 |
Drug-induced IgA deficiency in epileptic patients.
Topics: Adolescent; Adult; Age Factors; Depression, Chemical; Epilepsy; Female; Humans; IgA Deficiency; Immu | 1976 |
Interlaboratory variability in determination of plasma antiepileptic drug concentrations.
Topics: Anticonvulsants; Epilepsy; Ethosuximide; Humans; Laboratories; Phenobarbital; Phenytoin; Primidone; | 1976 |
Letter: Treatment of ethanol intoxication.
Topics: Alcoholism; Epilepsy; Humans; Phenytoin; Substance Withdrawal Syndrome | 1976 |
[Determination of serum diphenylhydantoin during antiepileptic therapy].
Topics: Adolescent; Adult; Aged; Body Weight; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Ma | 1976 |
Liver biopsies in epileptics during anticonvulsant therapy.
Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubi | 1976 |
Anticonvulsant osteomalacia determined by quantitative analysis of bone changes. Population study and possible risk factors.
Topics: Adolescent; Adult; Alkaline Phosphatase; Bone and Bones; Calcification, Physiologic; Calcium; Calciu | 1976 |
Radioimmunoassay, enzyme immunoassay, spectrophotometry, and gas-liquid chromatography compared for determination of phenobarbital and diphenylhydantoin.
Topics: Chromatography, Gas; Cross Reactions; Enzymes; Epilepsy; Evaluation Studies as Topic; Humans; Immuno | 1976 |
Treatment of epilepsy.
Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Male; Phenytoin; Valproic Acid | 1992 |
Cognitive functions, epileptic syndromes and antiepileptic drugs.
Topics: Adolescent; Adult; Carbamazepine; Child; Cognition; Epilepsy; Female; Humans; Male; Middle Aged; Phe | 1992 |
U-54494A reduces 4-AP-induced afterdischarges of CA1 pyramidal cells in the hippocampal slice of the rat.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Calcium; Electrophysiology; Epilepsy; Hippocampus; Male; | 1992 |
A study of nerve conduction velocity in patients on diphenylhydantoin therapy.
Topics: Action Potentials; Epilepsy; Humans; Motor Neurons; Neural Conduction; Neurons, Afferent; Peripheral | 1992 |
Salivary concentrations of antiepileptic drugs, oestradiol and progesterone throughout pregnancy in epileptic women.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Estradiol; Female; Humans; Osmolar Concentration; P | 1992 |
What to do when the first anticonvulsant does not work.
Topics: Aminocaproates; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Lamotrigine; Phenytoin; Treatment | 1992 |
Applications of molecular physics 'biotechnology' to the rational design of an improved phenytoin analogue.
Topics: Biotechnology; Computer Simulation; Drug Design; Epilepsy; Humans; Models, Molecular; Phenytoin; Phy | 1992 |
Therapeutic drug monitoring improves seizure control and reduces anticonvulsant side-effects in patients with refractory epilepsy.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Monitoring; Electroencephalog | 1992 |
Binding parameters of phenytoin during monotherapy and polytherapy.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Chromatography, Gas; Drug Interactions | 1992 |
Phenytoin-induced IgG2 and IgG4 deficiencies in a patient with epilepsy.
Topics: Child, Preschool; Epilepsy; Female; Humans; IgG Deficiency; Immunoglobulins; Immunoglobulins, Intrav | 1992 |
Incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients in general medical practice.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Child; Dental Plaque Index; England; Epilepsy; Female | 1992 |
Phenytoin metabolism during pregnancy.
Topics: Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications; Time Factors | 1992 |
[The problem of diffuse cranial hyperostosis following cerebral trauma in early childhood--a case report].
Topics: Brain Injuries; Epilepsy; Humans; Hyperostosis; Male; Middle Aged; Phenytoin | 1992 |
Induction of sister chromatid exchanges in phenytoin treated & untreated patients with epilepsy.
Topics: Adolescent; Adult; Epilepsy; Female; Humans; Male; Mutagenicity Tests; Phenytoin; Sister Chromatid E | 1992 |
Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases.
Topics: Adolescent; Adult; Angiography; Brain Neoplasms; Carbamazepine; Cerebral Hemorrhage; Child; Epilepsy | 1992 |
"An analysis of epileptic patients nonresponsive to drugs".
Topics: Anticonvulsants; Carbamazepine; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combina | 1992 |
Cognitive effects of antiepileptic drug discontinuation.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Epilepsy; Humans; | 1992 |
Bioavailability studies of drugs with nonlinear pharmacokinetics: I. Tracer dose AUC varies directly with serum concentration.
Topics: Adolescent; Adult; Aged; Biological Availability; Epilepsy; Humans; Male; Middle Aged; Phenytoin | 1992 |
Long-term influence of anticonvulsant agents on calcitonin, parathyroid hormone and osteocalcin.
Topics: Adult; Anticonvulsants; Calcitonin; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epi | 1992 |
Enhanced prostaglandin biosynthesis in human gingival fibroblasts isolated from patients treated with phenytoin.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acids; Cells, Cultured; Child; Dinoprostone; Dose-Response | 1992 |
Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbama | 1992 |
[Occurrence of the protozoa, Entamoeba gingivalis and Trichomonas tenax in the mouths of children and adolescents with hyperplastic gingivitis caused by phenytoin].
Topics: Adolescent; Animals; Child; Entamoeba; Epilepsy; Female; Gingivitis; Humans; Male; Mouth; Phenytoin; | 1992 |
Elevation of plasma phenytoin by viloxazine in epileptic patients: a clinically significant drug interaction.
Topics: Adult; Aged; Depressive Disorder; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Ph | 1992 |
Postmortem concentrations of phenytoin in different regions of the brain and in the serum: analysis of autoptic specimens from 24 epileptic patients.
Topics: Adult; Aged; Aged, 80 and over; Brain; Chromatography, High Pressure Liquid; Epilepsy; Female; Human | 1992 |
Phenytoin and carbamazepine decreased oral bioavailability of praziquantel.
Topics: Adult; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Male; Phenytoin; Praziquant | 1992 |
Comparison on bioequivalence of four phenytoin preparations in patients with multiple-dose treatment.
Topics: Administration, Oral; Biological Availability; Chemistry, Pharmaceutical; Chromatography, High Press | 1992 |
Phenytoin and smoking.
Topics: Adult; Aged; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Smoking; Tranquilizing Agents | 1992 |
Pharmacogenetics and drug interactions: role in antiepileptic-drug-induced teratogenesis.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Disease Susceptibility; Epilepsy; Epoxide Hydrolases; | 1992 |
Epilepsy, antiepileptic drugs, and malformations in children of women with epilepsy: a French prospective cohort study.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cohort Studies; Epilepsy; Female; Humans; Odds | 1992 |
Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Prescriptions; Epi | 1992 |
Clinical utility of unbound antiepileptic drug blood levels in the management of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Valproic Aci | 1992 |
Course of pregnancy and fetal outcome following maternal exposure to carbamazepine and phenytoin: a prospective study.
Topics: Abnormalities, Drug-Induced; Analysis of Variance; Carbamazepine; Epilepsy; Female; Humans; Phenytoi | 1992 |
Toxic reaction following the combined administration of fluoxetine and phenytoin: two case reports.
Topics: Aged; Aged, 80 and over; Depressive Disorder; Drug Therapy, Combination; Epilepsy; Female; Fluoxetin | 1992 |
[Long-term phenytoin (Diphedan) therapy leading to IgA nephropathy].
Topics: Adult; Epilepsy; Glomerulonephritis, IGA; Humans; Male; Nephritis, Interstitial; Phenytoin | 1992 |
Anticonvulsant-induced chronic pancreatitis. A case report.
Topics: Adult; Anticonvulsants; Carbamazepine; Chronic Disease; Cytochrome P-450 Enzyme System; Epilepsy; Fr | 1992 |
More on high-dose busulfan and seizure prophylaxis.
Topics: Adult; Bone Marrow Purging; Bone Marrow Transplantation; Busulfan; Epilepsy; Female; Humans; Leukemi | 1992 |
Kindling as a model of drug-resistant partial epilepsy: selection of phenytoin-resistant and nonresistant rats.
Topics: Animals; Carbamazepine; Drug Resistance; Electrodes; Epilepsy; Female; Kindling, Neurologic; Phenyto | 1991 |
Ralitoline (CI-946) and CI-953 block sustained repetitive sodium action potentials in cultured mouse spinal cord neurons and displace batrachotoxinin A 20-alpha-benzoate binding in vitro.
Topics: Action Potentials; Animals; Anticonvulsants; Batrachotoxins; Carbamazepine; Cells, Cultured; Electro | 1991 |
Phosphorylation of brain (Na+,K+)-ATPase alpha catalytic subunits in normal and epileptic cerebral cortex: I. The audiogenic mice and the cat with a freeze lesion.
Topics: Acoustic Stimulation; Animals; Brain; Catalysis; Cats; Cerebral Cortex; Electrophoresis, Polyacrylam | 1991 |
Phosphorylation of brain (Na+,K+)-ATPase alpha catalytic subunits in normal and epileptic cerebral cortex: II. Partial seizures in human epilepsy.
Topics: Brain; Catalysis; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Epilepsies, Partial; Epileps | 1991 |
Crusted scabies in acquired selective IgA deficiency.
Topics: Adult; Dysgammaglobulinemia; Epilepsy; Humans; IgA Deficiency; Male; Phenytoin; Scabies | 1991 |
Influence of antiepileptic drugs on sleep patterns.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain; Carbamazepine; Chil | 1991 |
Outpatient compliance with theophylline and phenytoin therapy.
Topics: Adolescent; Adult; Asthma; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Infant, Newbor | 1991 |
Estimating phenytoin dosages in black African and Indian children.
Topics: Adolescent; Bayes Theorem; Black People; Child; Child, Preschool; Epilepsy; Feedback; Humans; India; | 1991 |
A Bayesian graphic method for predicting individual phenytoin dosage schedule.
Topics: Adolescent; Adult; Bayes Theorem; Drug Administration Schedule; Epilepsy; Female; Humans; Male; Midd | 1991 |
[Evaluation of the effectiveness of monotherapy in the treatment of epilepsy].
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Drug Evaluation; Epilepsy; Humans; Middle Aged; Pheno | 1991 |
[Epilepsy in Spain: comments concerning an unusual factor in decompensation].
Topics: Anticonvulsants; Epilepsy; Humans; Phenytoin; Spain | 1991 |
Phenytoin toxicity in a patient with isoniazid-induced hepatitis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Interactions; Epilepsy; Female; Humans; Isoniazi | 1991 |
[Binding of phenytoin to serum albumin in vitro and in vivo].
Topics: Adult; Epilepsy; Female; Humans; In Vitro Techniques; Male; Phenytoin; Protein Binding; Serum Albumi | 1991 |
Mycosis fungoides-like lesions associated with phenytoin and carbamazepine therapy.
Topics: Adult; Aged; Aged, 80 and over; Carbamazepine; Diagnosis, Differential; Drug Eruptions; Epilepsy; Fe | 1991 |
[Altered monoamine metabolism in children with epilepsy].
Topics: Biogenic Monoamines; Child; Epilepsy; Female; Humans; Male; Phenytoin | 1991 |
Comparison of gabapentin with other antiepileptic and GABAergic drugs.
Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Carbamazepine; Cats; Cyclohexanecarbo | 1991 |
Plasma uric acid in patients receiving anticonvulsant monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenobarbital; Phenytoin; Prosp | 1991 |
Regression of phenytoin-induced gingival overgrowth after withdrawal of medication.
Topics: Adolescent; Child; Epilepsy; Female; Gingival Hyperplasia; Gingival Pocket; Humans; Male; Periodonta | 1991 |
Sleep spindles in epilepsy.
Topics: Adolescent; Adult; Aged; Carbamazepine; Drug Therapy, Combination; Electroencephalography; Epilepsy; | 1991 |
A specific 70K protein found in epileptic rat cortex: induction of bursting activity and negative resistance by its intracellular application in Euhadra neurons.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibody Specificity; Calcium; Cerebral Cortex; Electrophoresis | 1991 |
A reduction in verapamil concentrations with phenytoin.
Topics: Adult; Cardiomyopathy, Hypertrophic; Drug Interactions; Epilepsy; Female; Humans; Phenytoin; Verapam | 1991 |
[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Carbamazepine; Embryonic and Feta | 1991 |
Epileptic patients refractory to drug therapy.
Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Immunoglobulin G; Immunoglobulins; Male; Middle Aged | 1991 |
Clinical response in epilepsy in relation to total and free serum levels of phenytoin.
Topics: Adolescent; Adult; Aged; Biological Availability; Blood Proteins; Child; Child, Preschool; Drug Moni | 1991 |
Measurement of phenytoin and carbamazepine in an ultrafiltrate of saliva.
Topics: Adolescent; Adult; Aged; Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Drug | 1991 |
Methsuximide for intractable childhood seizures.
Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dr | 1991 |
A novel protein induced in cortical epileptic focus of rat cerebrum: a possible linkage to epileptogenesis.
Topics: Animals; Cerebral Cortex; Cobalt; Epilepsy; Immune Sera; Immunohistochemistry; Male; Microscopy, Ele | 1991 |
Seizures: introduction and commentary.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Humans; Phenobarbital; Phenytoin; Valpr | 1991 |
Seizure-associated speech arrest in elderly patients.
Topics: Aged; Aged, 80 and over; Aphasia; Electroencephalography; Epilepsy; Female; Humans; Male; Phenytoin | 1991 |
Evaluation and treatment of seizures.
Topics: Child; Epilepsy; Humans; Phenytoin; Seizures | 1991 |
Nomogram for the prediction of unbound phenytoin concentrations in patients on a combined treatment of phenytoin and valproic acid.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Chromatography, Gas; Chromatogr | 1991 |
Fetal phenytoin exposure, hypoplastic nails, and jitteriness.
Topics: Abnormalities, Drug-Induced; Akathisia, Drug-Induced; Epilepsy; Female; Fetus; Humans; Infant, Newbo | 1991 |
Comparison of methods for the prediction of phenytoin concentrations.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Bayes Theorem; Dose-Response Relationship, Drug; Epil | 1991 |
Epilepsy after craniotomy and the place of prophylactic anticonvulsant drugs: discussion paper.
Topics: Carbamazepine; Craniotomy; Epilepsy; Humans; Phenytoin; Postoperative Complications; Retrospective S | 1991 |
Hydantoin immunosuppression clinical study.
Topics: Adolescent; Adult; Antibody Formation; Epilepsy; Female; Humans; Immunoglobulins; Male; Middle Aged; | 1991 |
[Bradyarrhythmias induced by antiepileptics increase frequency of epileptic seizures].
Topics: Aged; Bradycardia; Carbamazepine; Epilepsy; Humans; Male; Phenytoin | 1991 |
Effects of acute valproic acid administration on carnitine plasma concentrations in epileptic patients.
Topics: Adult; Ammonia; Carnitine; Epilepsy; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1991 |
Protein changes associated with cobalt-induced epileptic activity in rat cerebral cortex.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Cobalt; Electroencephalography; Epilepsy; Male; Motor Co | 1991 |
Anti-IgA antibodies in epileptic patients with a low serum IgA concentration.
Topics: Antibodies, Anti-Idiotypic; Dysgammaglobulinemia; Epilepsy; Humans; IgA Deficiency; Immunoglobulin A | 1991 |
[Pellagra in anticonvulsive therapy].
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Humans; Intellect | 1990 |
The effects of phenytoin and carbamazepine on serum concentrations of mono-unsaturated metabolites of valproic acid.
Topics: Adult; Aged; Biotransformation; Carbamazepine; Drug Interactions; Epilepsy; Female; Humans; Male; Mi | 1990 |
Fluctuations of unbound and total phenytoin concentrations during the day in epileptic patients on valproic acid comedication.
Topics: Adolescent; Adult; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Middle Aged; Phen | 1990 |
Anticonvulsant therapy increases fentanyl requirements during anaesthesia for craniotomy.
Topics: Adolescent; Adult; Anesthesia, Intravenous; Anticonvulsants; Carbamazepine; Craniotomy; Drug Interac | 1990 |
Eyelid twitching seizures and generalized tonic-clonic convulsions: a syndrome of idiopathic generalized epilepsy.
Topics: Acetazolamide; Adult; Epilepsy; Eyelid Diseases; Female; Humans; Phenytoin; Spasm; Valproic Acid | 1990 |
Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy.
Topics: Administration, Oral; Adolescent; Adult; Carbamazepine; Chromatography, High Pressure Liquid; Drug I | 1990 |
Possible roles for frequent salivary antiepileptic drug monitoring in the management of epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Female; Humans; Male; Menstrua | 1990 |
[High-dose monotherapy in intractable epilepsy].
Topics: Adolescent; Adult; Carbamazepine; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; Female; Huma | 1990 |
Treatment of epilepsy in people with multiple handicap.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Disabled Persons; Epilepsy; Hum | 1990 |
Panel discussion: the oral manifestations of gingival hyperplasia.
Topics: Dental Care for Disabled; Epilepsy; Gingival Hyperplasia; Humans; Oral Hygiene; Phenytoin | 1990 |
Effect of posture on total phenytoin plasma concentration.
Topics: Adult; Aged; Epilepsy; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Phenytoin; Postur | 1990 |
Direct serum injection high-performance liquid chromatographic method for the simultaneous determination of phenobarbital, carbamazepine and phenytoin.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Humans; Immunoenzyme Techniques; Phen | 1990 |
Neocerebellar hypoplasia in a neonate following intra-uterine exposure to anticonvulsants.
Topics: Abnormalities, Drug-Induced; Cerebellum; Drug Therapy, Combination; Epilepsy; Female; Humans; Nerve | 1990 |
A specific 70 kDa protein induced in the epileptogenic cortex of rats elicits bursting activity and inactivation of potassium current in snail neurons.
Topics: Animals; Cerebral Cortex; Epilepsy; In Vitro Techniques; Membrane Potentials; Molecular Weight; Nerv | 1990 |
[A case of childhood choreoathetosis induced by diphenylhydantoin].
Topics: Athetosis; Chorea; Dose-Response Relationship, Drug; Epilepsy; Humans; Infant; Male; Phenytoin | 1990 |
Rapid anti-epileptic drug assay.
Topics: Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Hum | 1990 |
Foetal hydantoin syndrome.
Topics: Abnormalities, Multiple; Clubfoot; Epilepsy; Facial Bones; Female; Humans; Infant, Newborn; Phenytoi | 1990 |
Cardiac arrhythmia and epilepsy.
Topics: Adolescent; Epilepsy; Humans; Male; Phenytoin; Tachycardia, Supraventricular | 1990 |
Acne keloidalis-like lesions on the scalp associated with antiepileptic drugs.
Topics: Acne Keloid; Adult; Carbamazepine; Epilepsy; Humans; Male; Phenytoin; Scalp Dermatoses | 1990 |
Effects of age and antiepileptic drugs on plasma levels and kinetics of clobazam and N-desmethylclobazam.
Topics: Adolescent; Adult; Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepin | 1990 |
Deteriorating epilepsies: severely deteriorated cases.
Topics: Adult; Anticonvulsants; Ataxia; Brain Damage, Chronic; Diagnosis, Differential; Drug Therapy, Combin | 1990 |
Five epileptic cases who manifested psychotic states under the toxic levels of antiepileptic drugs.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Humans; Phen | 1990 |
Phenytoin induced osteomalacia and fracture in a young epileptic.
Topics: Adolescent; Epilepsy; Female; Femoral Neck Fractures; Humans; Osteomalacia; Phenytoin | 1990 |
Postmortem serum protein binding and brain concentrations of antiepileptic drugs in autoptic specimens from 45 epileptic patients.
Topics: Anticonvulsants; Blood Proteins; Brain; Carbamazepine; Epilepsy; Female; Humans; Male; Phenobarbital | 1990 |
[Blood levels of phenytoin. Pharmacokinetics and individualization of dosages in controlled children with crises and with persistence of crises].
Topics: Adolescent; Child; Epilepsy; Female; Humans; Male; Phenytoin | 1990 |
Cognitive function in adult epileptic patients established on anticonvulsant monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cognition; Epilepsy; Female; Humans; Intelligence | 1990 |
Plasma level distribution, effect and toxicity of antiepileptic drugs among Ethiopian epileptics.
Topics: Adolescent; Adult; Child; Drug Therapy, Combination; Epilepsy; Ethiopia; Female; Humans; Male; Pheno | 1990 |
[Paroxysmal kinesigenic choreoathetosis: autonomic disease or reflex epilepsy?].
Topics: Athetosis; Autonomic Nervous System Diseases; Child; Chorea; Diagnosis, Differential; Electroencepha | 1990 |
Pharmacokinetics and safety of a phenytoin prodrug given i.v. or i.m. in patients.
Topics: Adult; Aged; Electrocardiography; Epilepsy; Female; Half-Life; Hemodynamics; Humans; Infusions, Intr | 1990 |
[Therapeutic drug monitoring of phenytoin].
Topics: Adolescent; Adult; Age Factors; Biological Availability; Child; Child, Preschool; Dosage Forms; Drug | 1990 |
Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours.
Topics: Adult; Anticonvulsants; Brain Neoplasms; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged; | 1990 |
Anticonvulsant effects of zonisamide and phenytoin on seizure activity of the feline visual cortex.
Topics: Animals; Anticonvulsants; Cats; Dose-Response Relationship, Drug; Epilepsy; Female; Isoxazoles; Kind | 1990 |
Serum protein binding of antiepileptic drugs in Sri Lankans.
Topics: Adolescent; Adult; Anticonvulsants; Blood Proteins; Carbamazepine; Drug Therapy, Combination; Epilep | 1990 |
Direct high-performance liquid chromatographic analysis of p-hydroxyphenyl-phenylhydantoin glucuronide, the final metabolite of phenytoin, in human serum and urine.
Topics: Chromatography, High Pressure Liquid; Epilepsy; Glucuronates; Glucuronidase; Humans; Phenytoin; Ster | 1990 |
Treating epilepsy in Malawi: lessons learned.
Topics: Adult; Child; Epilepsy; Follow-Up Studies; Humans; Malawi; Patient Education as Topic; Phenobarbital | 1990 |
Monitoring of phenytoin in epileptic children: value of the single morning sample.
Topics: Adolescent; Blood Specimen Collection; Child; Circadian Rhythm; Epilepsy; Humans; Monitoring, Physio | 1990 |
Head circumference in children of epileptic mothers: contributions of drug exposure and genetic background.
Topics: Adult; Anticonvulsants; Carbamazepine; Child, Preschool; Epilepsy; Female; Humans; Intelligence Test | 1990 |
Pharmacokinetics of anticonvulsants in pregnancy: alterations in plasma protein binding.
Topics: Adult; Anticonvulsants; Blood Proteins; Carbamazepine; Epilepsy; Female; Humans; Maternal-Fetal Exch | 1990 |
A study of the interaction between omeprazole and phenytoin in epileptic patients.
Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Omeprazole; Phenytoin; Time F | 1990 |
[Population kinetic program for Michaelis-Menten elimination].
Topics: Epilepsy; Humans; Phenytoin; Software | 1990 |
Valproic acid and phenytoin effects on serum proteins and immunoglobulins of epileptic patients.
Topics: Adolescent; Adult; Aged; Alpha-Globulins; Beta-Globulins; Blood Proteins; Child; Child, Preschool; E | 1985 |
Interaction between 8-methoxypsoralen and phenytoin. Consequence for PUVA therapy.
Topics: Drug Interactions; Epilepsy; Female; Humans; Methoxsalen; Middle Aged; Phenytoin; Psoriasis; PUVA Th | 1985 |
Intelligence of children of epileptic mothers.
Topics: Child, Preschool; Developmental Disabilities; Epilepsy; Female; Humans; Intelligence; Intelligence T | 1988 |
Drugs for epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Epilepsy; Humans; Phenytoin; Valpro | 1989 |
Serum aspirin-esterase activity in epileptic patients receiving treatment with phenobarbital, phenytoin, carbamazepine and valproic acid.
Topics: Adult; Anticonvulsants; Aspirin; Carbamazepine; Epilepsy; Esterases; Female; Humans; Male; Phenobarb | 1989 |
IgG subclasses in epileptic patients treated with phenytoin.
Topics: Adolescent; Adult; Antibodies, Monoclonal; Epilepsy; Humans; Immunoglobulin gamma-Chains; Immunoglob | 1989 |
A model for managing epilepsy in a rural community in Africa.
Topics: Epilepsy; Health Education; Health Services Administration; Humans; Malawi; Mobile Health Units; Out | 1989 |
Derivation and evaluation of an equation for prediction of free phenytoin concentration in patients co-medicated with valproic acid.
Topics: Adult; Aged; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Mathematics; Middle Aged; Ph | 1989 |
Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism.
Topics: Adolescent; Adult; Aged; Antipyrine; Caffeine; Carbamazepine; Cytochrome P-450 Enzyme System; Enzyme | 1989 |
Thyroid hormone concentrations in epileptic patients.
Topics: Anticonvulsants; Carbamazepine; Drug Combinations; Epilepsy; Humans; Phenytoin; Thyrotropin; Thyroxi | 1989 |
Serum free levels and evaluation anticonvulsant drug interactions.
Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Valproi | 1989 |
Probable pseudocholinesterase induction by valproic acid, carbamazepine and phenytoin leading to increased serum aspirin-esterase activity in epileptics.
Topics: Adolescent; Adult; Analysis of Variance; Carbamazepine; Carboxylic Ester Hydrolases; Cholinesterases | 1989 |
[Clinical study of gingival hyperplasia in epilepsy patient].
Topics: Adult; Dental Care for Disabled; Epilepsy; Gingival Hyperplasia; Gingivectomy; Humans; Phenytoin | 1989 |
Axonal dystrophy in the posterior column nuclei of young adult epileptics with chronic phenytoin intoxication.
Topics: Adult; Axons; Epilepsy; Female; Gliosis; Humans; Inclusion Bodies; Male; Medulla Oblongata; Neural P | 1989 |
[The fetal hydantoin syndrome].
Topics: Adult; Epilepsy; Female; Hand Deformities, Congenital; Humans; Hypospadias; Infant, Newborn; Male; M | 1989 |
Clinical problems during the fast of Ramadan.
Topics: Drug Therapy; Epilepsy; Fasting; Female; Humans; Islam; Male; Patient Compliance; Phenytoin | 1989 |
Phenytoin and fasting.
Topics: Drug Administration Schedule; Epilepsy; Fasting; Half-Life; Humans; Phenytoin | 1989 |
Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices.
Topics: Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Cell Membrane Permeability; Epilepsy; Hipp | 1985 |
Dosing accuracy of antiepileptic drug regimens as determined by serum concentrations in outpatient epilepsy clinic patients.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Outpatients; Phenobarbital; Phenytoin | 1989 |
[The effect of vanillin on the fully amygdala-kindled seizures in the rat].
Topics: Amygdala; Animals; Anticonvulsants; Benzaldehydes; Disease Models, Animal; Epilepsy; Female; Kindlin | 1989 |
Serum immunoglobulins, complement levels and lymphocyte subpopulations in phenytoin-treated epileptic patients.
Topics: Adolescent; Adult; Antibodies, Monoclonal; Antibody Formation; Complement C3c; Complement C4; Comple | 1989 |
Level dose ratio and the threshold of intoxication level by dosages of three different phenytoin preparations.
Topics: Dose-Response Relationship, Drug; Epilepsy; Humans; Phenytoin | 1989 |
[A 11-year-old boy of idiopathic accelerated idioventricular rhythm].
Topics: Age Factors; Arrhythmias, Cardiac; Child; Echocardiography; Electrocardiography; Epilepsy; Humans; M | 1989 |
Daily salivary anticonvulsant monitoring in patients with intractable epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Monitoring, Physiologic; Phenobarbi | 1989 |
Cancer among epileptic patients exposed to anticonvulsant drugs.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Brain Neoplasms; Child; Child, Preschool; Denmark; | 1989 |
[Epileptic seizures in patients with a cerebrovascular infarction].
Topics: Adult; Aged; Aged, 80 and over; Cerebral Infarction; Electroencephalography; Epilepsy; Female; Human | 1989 |
Clinical and EEG response to anticonvulsants in neonatal seizures.
Topics: Anticonvulsants; Diazepam; Electroencephalography; Epilepsy; Humans; Infant, Newborn; Paraldehyde; P | 1989 |
Phenytoin withdrawal and seizure frequency.
Topics: Adult; Carbamazepine; Diazepam; Drug Therapy, Combination; Epilepsy; Epilepsy, Temporal Lobe; Female | 1989 |
Determination of enzyme or binding constants using generalized linear models, with particular reference to Michaelis-Menten models.
Topics: Adult; Enzymes; Epilepsy; Female; Humans; Models, Biological; Pharmacokinetics; Phenytoin; Pregnancy | 1989 |
Pregnancy and epilepsy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Estrogens; Female; Hum | 1989 |
The effect of anticonvulsants on the dexamethasone suppression test.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Carbamazepine; Depressive Disorder; Dexamethasone; Epileps | 1989 |
Pharmacology of ACC-9653 (phenytoin prodrug).
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Epilepsy; Heart Rate; Mice; Phenytoin; Prodrugs | 1989 |
Role of the cerebellum in complex human behavior.
Topics: Adult; Atrophy; Behavior; Cerebellum; Cognition Disorders; Epilepsy; Humans; Intelligence Tests; Neu | 1989 |
Modelling medical decision-making under uncertainty.
Topics: Decision Making; Drug Therapy, Computer-Assisted; Education, Medical; Epilepsy; Humans; Phenytoin; T | 1989 |
Serum 5'-nucleotidase in patients receiving anti-epileptic drugs.
Topics: 5'-Nucleotidase; Adolescent; Adult; Age Factors; Aged; Alkaline Phosphatase; Carbamazepine; Child; C | 1985 |
Genetic predisposition to phenytoin-induced birth defects.
Topics: Abnormalities, Multiple; Child; Epilepsy; Female; Humans; Phenytoin; Pregnancy | 1985 |
Factors that affect the induction of gamma glutamyltransferase in epileptic patients receiving anti-convulsant drugs.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Dose-Response Relationship, Drug; Dru | 1987 |
Gastritis with valproate therapy.
Topics: Adolescent; Antacids; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; | 1988 |
The influence of long-term anticonvulsant therapy with diphenylhydantoin and carbamazepine on serum gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Carbamazepine; Chemi | 1988 |
[Some experience in antiepileptic treatment drugs monitoring in clinic].
Topics: Adolescent; Adult; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Temazepam | 1988 |
[Altered gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase serum activities in long-term anticonvulsive therapy--comparison of diphenylhydantoin and carbamazepine].
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Carbamazepine; Cytoc | 1988 |
Effect of source of population data on phenytoin dosage predictions in black patients.
Topics: Adolescent; Adult; Aged; Bayes Theorem; Black People; Epilepsy; Europe; Feedback; Humans; Male; Midd | 1989 |
[Epileptics and their oral health].
Topics: Dental Care for Disabled; Epilepsy; Female; Gingival Hyperplasia; Humans; Male; Phenytoin | 1985 |
[Epileptic patients in dental treatment].
Topics: Adolescent; Adult; Anesthesia, Dental; Anesthesia, Local; Dental Care for Disabled; Epilepsy; Female | 1986 |
Development of phenytoin-induced gingival overgrowth in non-institutionalized epileptic children subjected to different plaque control programs.
Topics: Adolescent; Child; Dental Care for Disabled; Dental Plaque; Dental Plaque Index; Epilepsy; Female; G | 1987 |
[Convulsive attacks and the dentist].
Topics: Adolescent; Child; Child, Preschool; Dental Care for Disabled; Diazepam; Emergencies; Epilepsy; Ging | 1988 |
Different actions of vitamin D2 and D3 on bone metabolism in patients treated with phenobarbitone/phenytoin.
Topics: Adult; Alkaline Phosphatase; Bone and Bones; Calcium; Cholecalciferol; Double-Blind Method; Epilepsy | 1985 |
Different metabolism of vitamin D2/D3 in epileptic patients treated with phenobarbitone/phenytoin.
Topics: 24,25-Dihydroxyvitamin D 3; 25-Hydroxyvitamin D 2; Adult; Aged; Calcifediol; Calcium; Cholecalcifero | 1986 |
Impact of a pharmacokinetics consultation service on clinical outcomes in an ambulatory-care epilepsy clinic.
Topics: Carbamazepine; Epilepsy; Humans; Immunoenzyme Techniques; Outpatient Clinics, Hospital; Pharmacology | 1988 |
Carbamazepine, phenytoin and sodium valproate monotherapy.
Topics: Carbamazepine; Epilepsy; Humans; Phenytoin; Valproic Acid | 1986 |
Antiepileptic effects of globulin-N, an intact human immunoglobulin and its tissue-distribution in kindled cats.
Topics: Amygdala; Animals; Anticonvulsants; Autoradiography; Cats; Drug Combinations; Epilepsy; Half-Life; I | 1986 |
The influence of seizure type and medication on psychiatric symptoms in epileptic patients.
Topics: Adult; Anticonvulsants; Attention; Carbamazepine; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Tempora | 1986 |
Enhanced metabolism of levonorgestrel during phenytoin treatment in a woman with Norplant implants.
Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Kinetics; Levonorgestrel; Menstruation; Norgestr | 1986 |
Phenylethylmalonamide serum levels in patients treated with primidone and the effects of other antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Malonates; Phenobarbita | 1986 |
Drugs for epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Epilepsy; Humans; Phenytoin; Status | 1986 |
A comparative study of the relative influence of different anticonvulsant drugs, UV exposure and diet on vitamin D and calcium metabolism in out-patients with epilepsy.
Topics: Adult; Calcium; Carbamazepine; Diet; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Ultra | 1986 |
[Various matters concerning the improvement of therapeutic tactics in epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Drug Therapy, Comb | 1986 |
[Rational phenytoin therapy: a method for individualizing dosage].
Topics: Adolescent; Adult; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Kinetics; Male | 1986 |
[Relation between serum IgA and HLA in patients with epilepsy].
Topics: Adult; Epilepsy; Epilepsy, Tonic-Clonic; Female; HLA Antigens; HLA-A2 Antigen; Humans; Immunoglobuli | 1986 |
Memory disturbances in epileptic patients.
Topics: Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Memory Disorders; Phenytoin; Valproic Ac | 1986 |
Synergistic effects of oxiracetam and piracetam in combination with antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Clonazepam; Drug Synergism; Drug Therapy, Combination; Epil | 1986 |
Gynaecomastia induced by phenytoin in men with epilepsy.
Topics: Adult; Epilepsy; Gonadotropins; Gynecomastia; Humans; Male; Phenytoin; Steroids | 1987 |
Barbiturate-refractory epilepsy: safe schedule for therapeutic substitution.
Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Carbamazepine; Drug Tolerance; Epilepsy; Female; H | 1986 |
Anticonvulsant drugs in monotherapy. Effect on the fetus.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fe | 1987 |
Concurrent lupus anticoagulants and prothrombin deficiency due to phenytoin use.
Topics: Adult; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Coagulation Tests; Epilepsy; Hu | 1987 |
[Cognitive effects of antiepileptic drugs].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cognition Disorders; Epilepsy; | 1987 |
An interaction between cytostatic and anticonvulsant drugs.
Topics: Adenocarcinoma, Papillary; Adult; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carba | 1988 |
The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Midd | 1987 |
Adrenal cortex hormones in male epileptic patients before and during a 2-year phenytoin treatment.
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex; Adrenal Cortex Hormones; Adult; Epilepsies, Partial; Epil | 1988 |
[Ultrastructural study on phenytoin-induced gingival proliferation].
Topics: Adolescent; Epilepsy; Gingiva; Gingival Hyperplasia; Humans; Male; Phenytoin | 1988 |
Delayed bone development in epileptic children assessed by microdensitometer.
Topics: Adolescent; Anticonvulsants; Bone Development; Calcifediol; Calcitriol; Child; Child, Preschool; Den | 1988 |
A comparative study of the relative effects of anticonvulsant drugs and dietary folate on the red cell folate status of patients with epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Diet; Drug Therapy, Combination; Epilepsy; Erythrocytes; Fema | 1987 |
Predictability of unbound antiepileptic drug concentrations in children treated with valproic acid and phenytoin.
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Phenytoin; Prote | 1988 |
Variability of phenytoin, carbamazepine and valproate concentrations in a clinic population.
Topics: Carbamazepine; Epilepsy; Female; Humans; Male; Minnesota; Outpatient Clinics, Hospital; Patient Comp | 1988 |
[Clinical treatment of resistant epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Resistance; Electroencephalography; E | 1988 |
Changes in clearance of sodium valproate with changes in dose.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; M | 1987 |
Altered phenytoin clearance during intensive chemotherapy for acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Epilepsy; Humans; Leukemia, Lymphoid; Male; M | 1988 |
Phenytoin-induced resistance to pancuronium. Use of atracurium infusion in management of a neurosurgical patient.
Topics: Adolescent; Atracurium; Brain Neoplasms; Drug Interactions; Drug Tolerance; Epilepsy; Humans; Infusi | 1988 |
Gingival hyperplasia of an edentulous alveolar ridge in an epileptic--a case report.
Topics: Adult; Denture, Partial, Removable; Epilepsy; Female; Gingival Hyperplasia; Humans; Jaw, Edentulous, | 1988 |
Are phenobarbital and phenytoin obsolete in the treatment of epilepsy?
Topics: Epilepsy; Humans; Phenobarbital; Phenytoin | 1988 |
Long-term use of phenytoin: effect on haematological parameters in Nigerian epileptics.
Topics: Adolescent; Adult; Child; Epilepsy; Erythrocyte Indices; Female; Folic Acid; Hematocrit; Hematologic | 1988 |
Relevance of poor compliance for seizure control.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Middle Aged; Patient Compliance | 1988 |
Comparative determination of phenytoin in plasma by fluorescence polarization immunoassay and high performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Epilepsy; Fluorescent Antibody Technique; Humans; Phenytoin; R | 1987 |
Fatal paracetamol poisoning in an epileptic.
Topics: Acetaminophen; Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clobazam; Cytochrome | 1988 |
Minor anomalies in offspring of epileptic mothers.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Child; Child, Preschool; Congenital Abnormalities; E | 1988 |
Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics.
Topics: Adult; Aged; Epilepsy; Humans; Male; Middle Aged; Phenobarbital; Phenytoin | 1988 |
Phenytoin toxicity causing priapism.
Topics: Adult; Epilepsy; Humans; Male; Phenytoin; Priapism | 1988 |
Plasma and urinary taurine in epilepsy.
Topics: Anticonvulsants; Electroencephalography; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; T | 1988 |
Phenytoin-induced gum hypertrophy in patients with epilepsy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Drug Therapy, Combination; Epilepsy; Female; Ging | 1988 |
[Visual disorders caused by diphenylhydantoin: clinical and electro-ophthalmologic findings].
Topics: Electrooculography; Electroretinography; Epilepsy; Evoked Potentials, Visual; Female; Fluorescein An | 1988 |
Is free fraction measurement of phenytoin always necessary in pediatric epileptic patients?
Topics: Adolescent; Age Factors; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Monitoring | 1988 |
Evaluation of serum phenytoin monitoring in an acute care setting.
Topics: Acute Disease; Adult; Dose-Response Relationship, Drug; Epilepsy; Female; Hospitals, Teaching; Human | 1988 |
Comparison of a Bayesian forecasting technique with a new method for estimating phenytoin dose requirements.
Topics: Adult; Aged; Aged, 80 and over; Bayes Theorem; Epilepsy; Female; Humans; Male; Mathematics; Methods; | 1988 |
Onychopathy in a patient with fetal hydantoin syndrome.
Topics: Epilepsy; Female; Humans; Infant; Nail Diseases; Nails; Phenytoin; Pregnancy; Pregnancy Complication | 1988 |
Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance.
Topics: Adult; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Male; Middle Aged; Phenytoin; Tim | 1988 |
Corticosteroid-unresponsive pemphigus vulgaris following antiepileptic therapy.
Topics: Adult; Drug Interactions; Epilepsy; Humans; Male; Pemphigus; Phenobarbital; Phenytoin; Prednisolone; | 1988 |
Carbamazepine and phenytoin. Comparison of cognitive effects in epileptic patients during monotherapy and withdrawal.
Topics: Carbamazepine; Cognition; Epilepsy; Humans; Intelligence Tests; Neuropsychological Tests; Phenytoin | 1988 |
[Loading-doses of carbamazepine and diphenylhydantoin: use in high-risk patients].
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsy; Humans; Middle Aged; Phenytoin; Risk | 1987 |
[Cursive and gelastic manifestations of epilepsies].
Topics: Adolescent; Adult; Carbamazepine; Child; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; | 1987 |
[Clinical course and histological evaluation of hydantoin-induced gingival hyperplasia].
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Gingival Hyperplasia; Humans; Phenytoin | 1986 |
Oral health in non-institutionalized epileptic children with special reference to phenytoin medication.
Topics: Adolescent; Ambulatory Care; Child; Dental Caries; DMF Index; Epilepsy; Female; Humans; Male; Oral H | 1986 |
Putnam, Merritt, and the discovery of Dilantin.
Topics: Animals; Anticonvulsants; Boston; Epilepsy; History, 19th Century; History, 20th Century; Humans; Ph | 1986 |
[Diphenylhydantoin and primary hypothyroidism].
Topics: Epilepsy; Female; Humans; Hypothyroidism; Middle Aged; Phenytoin | 1986 |
Factors influencing the optimisation of phenytoin therapy in epileptic paediatric patients.
Topics: Child; Epilepsy; Humans; Phenytoin | 1987 |
Stereochemistry of aromatic phenytoin hydroxylation in various drug hydroxylation phenotypes in humans.
Topics: Adult; Chromatography, High Pressure Liquid; Epilepsy; Epoxy Compounds; Female; Glucuronates; Humans | 1987 |
Minor additive inducing effects of phenobarbital on carbamazepine clearance in patients on combined carbamazepine-phenytoin therapy.
Topics: Aged; Carbamazepine; Drug Interactions; Epilepsy; Humans; Male; Middle Aged; Phenobarbital; Phenytoi | 1987 |
Transient global amnesia and epilepsy. Electroencephalographic distinction.
Topics: Amnesia; Electroencephalography; Epilepsy; Humans; Male; Middle Aged; Phenytoin | 1987 |
[Electrophysiologic changes after taking sodium phenytoin].
Topics: Adult; Alpha Rhythm; Epilepsy; Female; Humans; Male; Neural Conduction; Phenytoin | 1986 |
Cognitive effects of phenytoin during monotherapy and after withdrawal.
Topics: Adult; Attention; Cognition; Epilepsy; Humans; Middle Aged; Neuropsychological Tests; Phenytoin; Psy | 1987 |
Monitoring of drug therapy in epileptic children.
Topics: Child; Epilepsy; Humans; Monitoring, Physiologic; Phenobarbital; Phenytoin | 1987 |
Phenytoin and carbamazepine, alone and in combination: anticonvulsant and neurotoxic effects.
Topics: Animals; Brain; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Co | 1987 |
Population pharmacokinetics of phenytoin in South African black patients.
Topics: Adolescent; Adult; Black People; Child; Epilepsy; Female; Humans; Kinetics; Male; Middle Aged; Pheny | 1987 |
Desipramine and phenytoin: a potential drug interaction of therapeutic relevance.
Topics: Adult; Depressive Disorder; Desipramine; Drug Interactions; Epilepsy; Female; Humans; Male; Phenytoi | 1987 |
Folate metabolism and problem behaviour in mentally handicapped epileptics.
Topics: Adolescent; Adult; Aged; Epilepsy; Female; Folic Acid; Humans; Intellectual Disability; Male; Mental | 1987 |
Serum phenytoin during pregnancy, labor and puerperium.
Topics: Adult; Epilepsy; Female; Humans; Labor, Obstetric; Osmolar Concentration; Phenytoin; Postpartum Peri | 1987 |
Your CE topic this month (No. 20). Antiepileptic pharmacotherapy.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Humans; Nu | 1986 |
Development of presenile cataracts in association with high serum levels of phenytoin.
Topics: Adult; Cataract; Epilepsy; Humans; Male; Phenytoin | 1987 |
Kindling models and antikindling effects of mood normalizers.
Topics: Animals; Cats; Diethylcarbamazine; Electric Stimulation; Epilepsy; Humans; Kindling, Neurologic; Lit | 1987 |
Utilization of Km for phenytoin dosage after folate addition to patient regimen.
Topics: Adult; Aged; Epilepsy; Folic Acid; Humans; Male; Middle Aged; Phenytoin | 1987 |
Response of polygraphic sleep to phenytoin treatment for epilepsy. A longitudinal study of immediate, short- and long-term effects.
Topics: Adult; Epilepsy; Female; Humans; Longitudinal Studies; Phenytoin; Sleep; Sleep, REM; Time Factors | 1987 |
Spread and arrest of seizures: the importance of layer 4 in laminar interactions during neocortical epileptogenesis.
Topics: Action Potentials; Animals; Anticonvulsants; Bicuculline; Biomechanical Phenomena; Cats; Cerebral Co | 1986 |
Prevalence of toxic anticonvulsant drug concentrations in mentally retarded persons with epilepsy.
Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Intellectual Disability; Kinetics; Male; Phenytoin; | 1986 |
Does prolonged use of diphenylhydantoin predispose to pulmonary sarcoidosis?
Topics: Adult; Epilepsy; Female; Humans; Immunoglobulins; Lung Diseases; Lymphocyte Activation; Lymphocytes; | 1986 |
Measuring anti-convulsant levels in the accident and emergency department.
Topics: Adult; Carbamazepine; Emergencies; Epilepsy; Humans; Patient Compliance; Phenobarbital; Phenytoin; P | 1986 |
Assessment of polymorphonucleate leucocyte functions in adult epileptic patients undergoing long-term phenytoin treatment.
Topics: Adult; Aged; Chemotaxis, Leukocyte; Epilepsy; Female; Humans; Leukocyte Count; Male; Middle Aged; Ne | 1986 |
Decision-making in refractory epilepsy: an analysis based on computer simulation.
Topics: Carbamazepine; Computers; Epilepsy; Humans; Models, Theoretical; Patient Compliance; Phenytoin | 1986 |
Comparative pharmacokinetics of zonisamide (CI-912) in epileptic patients on carbamazepine or phenytoin monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Body Weight; Carbamazepine; Drug Therapy, Combination; Epilepsy; | 1986 |
[Phenomenon of "paradoxical poisoning" during antiepileptic therapy].
Topics: Adult; Anticonvulsants; Barbiturates; Carbamazepine; Child; Drug Synergism; Drug Therapy, Combinatio | 1986 |
[Concentration of benzonal in the blood of epileptic patients at different daily doses and with other anticonvulsants].
Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Benzamidines; Epilepsy; Female; Humans; Male; Phen | 1986 |
Interaction of dietary pudding with phenytoin.
Topics: Adolescent; Adult; Child; Drug Interactions; Epilepsy; Female; Food, Formulated; Humans; Male; Middl | 1986 |
[Drug interactions with phenytoin and carbamazepine].
Topics: Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin | 1986 |
[Determination of sodium phenytoin concentration in the blood by radioimmunologic PEG].
Topics: Adolescent; Adult; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Radioimmunoassay | 1986 |
Epilepsy and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant Care; Infant, Newborn | 1986 |
Effect of influenza vaccine on serum anticonvulsant concentrations.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Influenza Vaccines; Inf | 1986 |
Epilepsy after operation for aneurysms.
Topics: Craniotomy; Epilepsy; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Phenytoin; Postopera | 1986 |
Developmental effects of anticonvulsants.
Topics: Animals; Anticonvulsants; Body Weight; Epilepsy; Female; Fetal Diseases; Humans; Motor Activity; Phe | 1986 |
Phenytoin kinetics during pregnancy and the puerperium.
Topics: Adult; Epilepsy; Female; Fetal Blood; Humans; Kinetics; Phenytoin; Postpartum Period; Pregnancy; Pre | 1986 |
Phenytoin vs carbamazepine in seizure disorder.
Topics: Carbamazepine; Epilepsy; Humans; Phenytoin | 1986 |
Effect of simultaneously ingested milk on phenytoin bioavailability.
Topics: Adult; Aged; Animals; Biological Availability; Epilepsy; Humans; Male; Middle Aged; Milk; Phenytoin; | 1985 |
Availability of drug assay results and dosage advice improves antiepileptic care in a specialist neurology outpatient clinic.
Topics: Adolescent; Adult; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Humans; Outpatient Cli | 1985 |
Studies of qingyangshen (root of Cynanchum otophyllum). I. Effect of qingyangshen on copper and zinc metabolism.
Topics: Animals; Anticonvulsants; Copper; Drugs, Chinese Herbal; Epilepsy; Medicine, Chinese Traditional; Me | 1985 |
The effects of long-term anticonvulsant drug therapy on vitamin D metabolites and mineral homeostasis in pregnant epileptic women and their newborns.
Topics: Adolescent; Adult; Anticonvulsants; Calcifediol; Calcitriol; Carbamazepine; Dihydroxycholecalciferol | 1985 |
Effect of chronic anticonvulsant monotherapy on lymphocyte subpopulations in adult epileptic patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Complement System Proteins; Epilepsy; Femal | 1985 |
Examination of infants for both minor and major malformations to evaluate for possible teratogenic exposures.
Topics: Abnormalities, Drug-Induced; Diabetes Mellitus, Type 1; Epilepsy; Female; Gonadal Steroid Hormones; | 1985 |
Isolated malignant lymphoma of the jejunum and long-term diphenylhydantoin therapy.
Topics: Aged; Epilepsy; Humans; Jejunal Neoplasms; Lymphoma, Large B-Cell, Diffuse; Male; Phenytoin; Time Fa | 1985 |
Ultrafiltration compared with equilibrium dialysis in the determination of unbound phenytoin in plasma.
Topics: Blood Proteins; Dialysis; Epilepsy; Humans; Immunoenzyme Techniques; Phenytoin; Protein Binding; Ult | 1985 |
[Side effects of anticonvulsants on the peripheral nervous system and vestibulo-ocular functions].
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Epilepsy, Temporal Lobe; | 1985 |
Time-dependent interaction between phenytoin and valproic acid.
Topics: Adolescent; Adult; Child; Child, Preschool; Circadian Rhythm; Drug Interactions; Drug Therapy, Combi | 1985 |
[Acute liver necrosis caused by valproate].
Topics: Adult; Creatine Kinase; Epilepsy; Female; Humans; Liver Cirrhosis; Phenytoin; Transaminases; Valproi | 1985 |
Effects of pregnancy on antiepileptic drug utilization.
Topics: Anticonvulsants; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Kinetics; Metabol | 1985 |
Adaptation of hepatic ammonia metabolism after chronic valproate administration in epileptics treated with phenytoin.
Topics: Adaptation, Physiological; Adult; Ammonia; Drug Interactions; Drug Therapy, Combination; Epilepsy; H | 1985 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M | 1985 |
The effects of phenytoin and sodium valproate on the periodontal health of adult epileptic patients.
Topics: Adolescent; Adult; Aged; Alveolar Process; Bone Resorption; Cross-Sectional Studies; Dental Plaque I | 1985 |
Drug compliance and seizure control in epileptic children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infan | 1985 |
Monotherapy and polytherapy for intractable epilepsies.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clobazam; D | 1985 |
Interictal EEG prediction of response to antiepileptic drug monotherapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Electroencephalogr | 1985 |
Evaluation of the effects of antiepileptic drugs on sleep-wakefulness patterns following 1 night total sleep deprivation in epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Human | 1985 |
Chronic valproic acid therapy and incidence of increases in venous plasma ammonia.
Topics: Adolescent; Adult; Aged; Ammonia; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epileps | 1985 |
The optimum use of anticonvulsants.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phen | 1985 |
Mortality from ischaemic heart disease among patients using anticonvulsive drugs: a case-control study.
Topics: Aged; Anticonvulsants; Barbiturates; Carbamazepine; Cardiovascular Diseases; Cerebrovascular Disorde | 1985 |
Where, why, and what type of therapy.
Topics: Carbamazepine; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Hum | 1985 |
Monitoring: the most important role of the pediatrician.
Topics: Activities of Daily Living; Anticonvulsants; Carbamazepine; Child, Preschool; Environmental Monitori | 1985 |
Serum concentrations of valproic acid: influence of dose and comedication.
Topics: Adolescent; Adult; Body Weight; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epileps | 1985 |
Influence of anticonvulsant drugs on thyroid hormones in epileptic children.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Mephenytoin; Phenytoin; Primidone; Thyro | 1985 |
Use of total and free anticonvulsant serum levels in clinical practice.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Immunoenzyme Techniques; Phenobarbital; Phenytoin; | 1985 |
Alternative single anticonvulsant drug therapy for refractory epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Chronic Disease; Epilepsy; Humans; Phenobarbital; Phenytoin; | 1986 |
The influence of seizure type on the efficacy of plasma concentrations of phenytoin, phenobarbital, and carbamazepine.
Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin | 1986 |
Maternal anticonvulsants and fetal hemorrhage. A report of two cases.
Topics: Adolescent; Adult; Cesarean Section; Epilepsy; Female; Fetal Diseases; Hemorrhage; Hemostasis; Human | 1986 |
Ovarian hormones, anticonvulsant drugs, and seizures during the menstrual cycle in women with epilepsy.
Topics: Adolescent; Adult; Epilepsy; Estradiol; Estriol; Estrone; Female; Gonadal Steroid Hormones; Humans; | 1986 |
Behavioral and cognitive impairments in children with epilepsy: the long-term effects of anticonvulsant therapy.
Topics: Adolescent; Anticonvulsants; Child; Child Behavior Disorders; Child, Preschool; Electroencephalograp | 1985 |
Hypothyroidism and phenytoin intoxication.
Topics: Aged; Epilepsy; Female; Humans; Hypothyroidism; Phenytoin; Thyrotropin; Thyroxine | 1985 |
Carbamazepine and carbamazepine-10,11-epoxide serum concentrations in epileptic children.
Topics: Adolescent; Age Factors; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy | 1985 |
Thyroid function in epileptic mothers and their infants at birth.
Topics: Anticonvulsants; Epilepsy; Female; Fetal Blood; Humans; Infant, Newborn; Phenytoin; Pregnancy; Pregn | 1985 |
Differential effect of cimetidine on serum concentrations of carbamazepine and phenytoin.
Topics: Adolescent; Adult; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Hu | 1985 |
Anticonvulsant use during pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Death; Humans; Phenobarbital; | 1985 |
Dosage of phenytoin during pregnancy.
Topics: Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications | 1985 |
Carbamazepine-phenytoin interaction: elevation of plasma phenytoin concentrations due to carbamazepine comedication.
Topics: Adult; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; | 1985 |
Steady-state serum levels of anticonvulsant drugs in Chinese epileptic patients living in Taiwan.
Topics: Adolescent; Adult; Age Factors; Asian People; Body Weight; Child; Epilepsy; Female; Humans; Male; Mi | 1985 |
Bioavailability of phenytoin: comparison between three preparations.
Topics: Adult; Biological Availability; Chemistry, Pharmaceutical; Dosage Forms; Epilepsy; Female; Humans; K | 1985 |
CT findings following diphenylhydantoin intoxication.
Topics: Adult; Cerebellar Ataxia; Child; Epilepsy; Female; Humans; Phenytoin; Tomography, X-Ray Computed | 1985 |
Epilepsy in a community--management and social impact.
Topics: Adolescent; Adult; Aged; Ambulatory Care Facilities; Carbamazepine; Craniocerebral Trauma; Epilepsy; | 1985 |
Effect of antiepileptic drugs on short-latency somatosensory evoked potentials.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephal | 1985 |
Gas chromatographic determination of m- and p-hydroxyphenytoin in the urine of epileptic patients.
Topics: Adult; Aged; Carbamazepine; Chromatography, Gas; Epilepsy; Female; Humans; Hydrolysis; Male; Phenyto | 1985 |
Stable-isotope methodology for the bioavailability study of phenytoin during multiple-dosing regimens.
Topics: Adult; Biological Availability; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Ma | 1985 |
Reversible chronic cerebellar ataxia after phenytoin intoxication: possible role of cerebellum in cognitive thought.
Topics: Adolescent; Cerebellar Ataxia; Cerebellum; Chronic Disease; Cognition; Electroencephalography; Elect | 1985 |
Epileptic amnesic attacks: benefit from antiepileptic drugs.
Topics: Aged; Amnesia; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Male; Middle Aged; Neuropsychologic | 1985 |
Damage of Purkinje cell axons following chronic phenytoin administration: an animal model of distal axonopathy.
Topics: Animals; Axons; Central Nervous System Diseases; Disease Models, Animal; Epilepsy; Male; Mice; Mice, | 1985 |
[The variability of plasma protein binding of phenytoin in epileptic patients with hypoalbuminemia].
Topics: Adult; Aged; Blood Proteins; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Protein Binding | 1985 |
The clinical value of free phenytoin levels.
Topics: Adolescent; Adult; Epilepsy; Humans; Middle Aged; Phenytoin | 1985 |
Sister chromatid exchanges in adult epileptic patients on phenytoin therapy.
Topics: Adult; Epilepsy; Humans; Lymphocytes; Middle Aged; Mutation; Phenytoin; Sister Chromatid Exchange; T | 1985 |
[Clinical significance of blood levels of diphenylhydantoin orally administered to epileptic patients].
Topics: Administration, Oral; Adolescent; Adult; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenyto | 1985 |
[Anticonvulsive prophylaxis after juvenile craniocerebral injuries: a retrospective evaluation].
Topics: Anticonvulsants; Brain Concussion; Child; Drug Therapy, Combination; Electroencephalography; Epileps | 1985 |
[Diphenylhydantoin poisoning in monotherapy and in combination with other antiepileptic drugs].
Topics: Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin | 1985 |
Increased frequency of goitre in epileptic patients on long-term phenytoin or carbamazepine treatment.
Topics: Adolescent; Adult; Aged; Carbamazepine; Epilepsy; Female; Goiter; Humans; Male; Middle Aged; Phenyto | 1985 |
Ambulatory cassette EEG in clinical practice.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Child; Child, Preschool; Electroencephalography; Epilepsy; | 1985 |
Incidence of seizures with phenytoin toxicity.
Topics: Adult; Epilepsy; Female; Humans; Infant; Male; Middle Aged; Phenytoin; Retrospective Studies; Seizur | 1985 |
Prolactin and growth hormone dynamics in epileptic patients receiving phenytoin.
Topics: Adolescent; Adult; Bromocriptine; Epilepsy; Female; Growth Hormone; Humans; Male; Metoclopramide; Mi | 1985 |
[Macrocytic anemia due to folic acid deficiency and non-Hodgkin's lymphoma associated with prolonged diphenylhydantoin ingestion].
Topics: Aged; Anemia, Macrocytic; Epilepsy; Female; Folic Acid Deficiency; Humans; Lymphoma; Phenytoin; Time | 1985 |
Michaelis-Menten kinetics and the steady-state serum phenytoin/hydroxyphenytoin ratio.
Topics: Adolescent; Adult; Child; Epilepsy; Half-Life; Humans; Kinetics; Middle Aged; Phenytoin | 1985 |
Phenytoin/clonazepam interaction.
Topics: Adult; Benzodiazepinones; Clonazepam; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans | 1985 |
The role of antiepileptics in sudden death in epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Death, Sudden; Epilepsy; Female; Humans; Male; Patient Compli | 1985 |
Multiple sclerosis in childhood: long term katamnestic investigations.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; | 1985 |
[Methods of individualizing phenytoin dosage].
Topics: Drug Administration Schedule; Epilepsy; Humans; Methods; Phenytoin | 1985 |
Comparative safety of carbamazepine & phenytoin in the treatment of epilepsy.
Topics: Carbamazepine; Cells, Cultured; Epilepsy; Humans; Lymphocytes; Phenytoin; Sister Chromatid Exchange | 1985 |
[Convulsive crises in childhood].
Topics: Clonazepam; Crying; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Infant; Infant, Newborn; Mi | 1985 |
Effects of diphenylhydantoin and cholinergic agents on the neuronally isolated cerebral cortex.
Topics: Animals; Atropine; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; | 1971 |
Plasma gamma-glutamyl transpeptidase elevation in patients receiving enzyme-inducing drugs.
Topics: Acyltransferases; Depression; Drug Synergism; Enzyme Induction; Epilepsy; Ethanol; Glutamates; Human | 1971 |
Is phenytoin carcinogenic?
Topics: Carcinogens; Cell Transformation, Neoplastic; Epilepsy; Humans; Lymphatic Diseases; Lymphoma; Phenyt | 1971 |
Congenital malformations among infants born to epileptic women.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Congenital Abnormalities; England; Epilepsy; F | 1973 |
4 C-sex vertex spindles.
Topics: Action Potentials; Brain; Brain Concussion; Cerebrovascular Disorders; Electroencephalography; Epile | 1973 |
Errors in phenytoin dosage.
Topics: Ataxia; Child; Child, Preschool; Epilepsy; Female; Headache; Humans; Male; Medication Errors; Phenyt | 1973 |
Letter: Chronic phenytoin therapy and carbohydrate tolerance.
Topics: Adolescent; Adult; Child; Epilepsy; Glucose Tolerance Test; Humans; Hyperglycemia; Pancreas; Phenyto | 1973 |
Coarse features in epilepsy as a consequence of anticonvulsant therapy. Report of cases in two pairs of identical twins.
Topics: Acromegaly; Adult; Anticonvulsants; Carbamazepine; Child; Diazepam; Diseases in Twins; Epilepsy; Epi | 1973 |
Are anticonvulsants oncogenic?
Topics: Anticonvulsants; Denmark; Epilepsy; Female; Humans; Male; Neoplasms; Phenobarbital; Phenytoin; Primi | 1974 |
Letter: Anticonvulsants and congenital abnormalities.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Female; Fingers; He | 1974 |
Comparison of spectrophotometric and gas-liquid chromatographic measurements of serum diphenylhydantoin concentrations in epileptic out-patients.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Child; Chromatography, Gas; Epilepsy; Female; Humans; Male | 1974 |
Phenytoin and folate deficiency: failure to show dose dependency.
Topics: Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenytoin; Time Factors | 1974 |
Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin).
Topics: Adolescent; Adult; Aged; Antibody Formation; Antigens, Bacterial; Child; Epilepsy; Hodgkin Disease; | 1971 |
[Calcium metabolism during antiepileptic therapy].
Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Antipsychotic Agents; Calcium; Calcium Isotopes; Creat | 1973 |
[Frequency of rickets-like bone lesions during anticonvulsive therapy].
Topics: Adolescent; Anticonvulsants; Barbiturates; Bone Development; Carpal Bones; Child; Child, Preschool; | 1973 |
[Diphenylhydantoin in children. Clinico-pharmacological studies].
Topics: Adolescent; Alkaline Phosphatase; Ataxia; Body Weight; Calcium; Child; Child, Preschool; Diplopia; D | 1973 |
Clonazepam (Ro 5-4023) in the treatment of myoclonus epilepsy. Four case reports.
Topics: Adult; Anticonvulsants; Benzodiazepinones; Chlorobenzenes; Diazepam; Drug Therapy, Combination; Elec | 1973 |
Proceedings: Inhibition of phenytoin metabolism by sulthiame.
Topics: Anticonvulsants; Depression, Chemical; Drug Interactions; Epilepsy; Humans; Phenytoin; Thiazines | 1973 |
Choreo-athetosis and encephalopathy induced by phenytoin.
Topics: Adolescent; Adult; Ataxia; Athetosis; Carbamazepine; Chorea; Diplopia; Electroencephalography; Epile | 1974 |
Prevalence and treatment of vitamin D deficiency in children on anticonvulsant drugs.
Topics: Adolescent; Alkaline Phosphatase; Anticonvulsants; Calcium; Cholecalciferol; Diet; Enzyme Induction; | 1974 |
Assessment of plasma glutamyl transpeptidase activity and urinary D-glucaric acid excretion as indices of enzyme induction.
Topics: Adipates; Anticonvulsants; Child; Child, Preschool; Enzyme Induction; Epilepsy; Female; gamma-Glutam | 1974 |
Epilepsy.
Topics: Adrenocorticotropic Hormone; Carbamazepine; Diazepam; Drug Hypersensitivity; Drug-Related Side Effec | 1974 |
Gastrointestinal function in anticonvulsant megaloblastic anaemia.
Topics: Adult; Anemia, Macrocytic; Epilepsy; Female; Folic Acid; Humans; Intestinal Absorption; Phenobarbita | 1966 |
Effects of folic acid on the mental state and fit-frequency of drug-treated epileptic patients.
Topics: Adolescent; Adult; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Humans; M | 1967 |
Neuropsychiatric aspects of anticonvulsant megaloblastic anaemia.
Topics: Acetazolamide; Adult; Anemia, Macrocytic; Epilepsy; Female; Folic Acid; Humans; Male; Middle Aged; P | 1968 |
Sources of error in the determination of phenytoin (Dilantin) by Svensmark & Kristensen's method.
Topics: Dicumarol; Epilepsy; Ethosuximide; Humans; Methods; Phenylbutazone; Phenytoin; Spectrophotometry | 1967 |
Longitudinal EEG and clinical study of children with febrile convulsions.
Topics: Acute Disease; Age Factors; Blood Chemical Analysis; Cerebral Cortex; Child, Preschool; Electroencep | 1968 |
A neuropathological study of a case of petit mal epilepsy.
Topics: Adolescent; Basal Ganglia; Brain; Cerebellum; Cerebral Cortex; Epilepsy; Epilepsy, Absence; Ethosuxi | 1968 |
Folic acid and anticonvulsants.
Topics: Anticonvulsants; Epilepsy; Folic Acid; Humans; Nervous System Diseases; Phenytoin | 1969 |
Acute effects of Dilantin on the EEG of epileptic patients: a quantitative study.
Topics: Blood-Brain Barrier; Electroencephalography; Epilepsy; Humans; Phenytoin | 1970 |
Neonatal coagulation defect due to anticonvulsant drug treatment in pregnancy.
Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Blood Coagulation Disorders; Blood Coagulation Tes | 1970 |
Coagulation defect due to anticonvulsant drug treatment in pregnancy.
Topics: Adult; Blood Coagulation Disorders; Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, Dise | 1970 |
Neonatal haemorrhage following maternal anticonvulsant therapy.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Male; Phenobarbital; Phenytoin; P | 1970 |
A case of reading epilepsy with observations on the effect of sleep deprivation and fasting on eeg correlates.
Topics: Adult; Electroencephalography; Epilepsy; Fasting; Humans; Male; Phenytoin; Reading; Sleep Deprivatio | 1970 |
Effect of anticonvulsant drugs on insecticide residues.
Topics: Agriculture; Epilepsy; Humans; Insecticides; Phenobarbital; Phenytoin | 1970 |
Abnormal pharmacokinetics of phenytoin in a patient with uraemia.
Topics: Epilepsy; Humans; Male; Middle Aged; Phenytoin; Uremia | 1970 |
The effect of anticonvulsant therapy upon the absorption of folates.
Topics: Adult; Aged; Anticonvulsants; Biological Assay; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; | 1973 |
[Inheritance of spike-wave complexes and febrile seizures in three generations].
Topics: Adult; Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; Ethosuximi | 1973 |
Antiepileptic therapy and rickets in children.
Topics: Adolescent; Anticonvulsants; Barbiturates; Child; Child, Preschool; Diazepam; Epilepsy; Epilepsy, To | 1973 |
[Phenytoin-induced folic acid deficiency].
Topics: Adult; Aged; Anemia, Macrocytic; Epilepsy; Epilepsy, Post-Traumatic; Female; Folic Acid; Folic Acid | 1973 |
The pattern of epilepsy in Uganda.
Topics: Adolescent; Adult; Age Factors; Black People; Child; Child, Preschool; Electroencephalography; Epile | 1973 |
Folate studies in underprivileged children with epilepsy.
Topics: Anticonvulsants; Biological Assay; Child; Child, Preschool; Epilepsy; Euglena; Folic Acid; Hematocri | 1973 |
Binding of folic acid to serum proteins. II. The effect of diphenylhydantoin treatment and of various diseases.
Topics: Adolescent; Adult; Aged; Blood Proteins; Chromatography, Ion Exchange; Dextrans; Epilepsy; Fatty Aci | 1973 |
[Worsening of epilepsies under treatment].
Topics: Anticonvulsants; Benzodiazepinones; Child; Child, Preschool; Chlorobenzenes; Drug Therapy, Combinati | 1973 |
Epilepsy in cerebral hydatidosis.
Topics: Adolescent; Adult; Brain Diseases; Child; Child, Preschool; Dominance, Cerebral; Echinococcosis; Ele | 1974 |
[A case of phenytoin intoxication].
Topics: Adult; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Male; Phenytoin | 1974 |
[Enhanced drug hydroxylation in man under diphenyl-hydantoin therapy].
Topics: Administration, Oral; Antipyrine; Biodegradation, Environmental; Creatinine; Epilepsy; Epilepsy, Ton | 1974 |
Folic acid and dilantin antagonism in pregnancy.
Topics: Adult; Chromatography, Gas; Drug Antagonism; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Fe | 1974 |
Inhibition of intestinal absorption of folic acid by phenytoin.
Topics: Adult; Aged; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Hydrogen-Ion Concentration | 1974 |
Occipital lobe epilepsy. A clinical and electroencephalographic study.
Topics: Adolescent; Adult; Blindness; Child; Diagnosis, Differential; Electroencephalography; Epilepsy; Epil | 1974 |
Anticonvulsant effect of diphenylhydantoin relative to plasma levels. A prospective three-year study in ambulant patients with generalized epileptic seizures.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Ataxia; Chromatography, Gas; Epilepsy; Epilepsy, Tonic-Clo | 1974 |
Clonazepam in the treatment of epilepsy.
Topics: Adult; Anticonvulsants; Benzodiazepinones; Chlorobenzenes; Chromatography, Gas; Drug Interactions; E | 1974 |
Therapy of seizures in children.
Topics: Child; Diazepam; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Injections, Intramuscular; Injec | 1974 |
[Polyneuropathy due to diphenylhydantoin overdosage].
Topics: Adult; Epilepsy; Humans; Long-Term Care; Male; Paralysis; Phenytoin; Polyneuropathies | 1974 |
Prolonged trance-like stupor in epilepsy. Petit mal status-wave stupor, spaced-out status.
Topics: Adult; Behavior; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Abse | 1974 |
[Letter: Ovulation inhibitors during anticonvulsive therapy?].
Topics: Adult; Anticonvulsants; Contraceptives, Oral; Drug Interactions; Epilepsy; Female; Humans; Long-Term | 1974 |
[Myopathy and osteomalacia after longterm antiepileptic treatment (author's transl)].
Topics: Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Calcium; Calcium Metabolism Disorders; Chi | 1974 |
The dysmorphogenic potential of phenytoin: experimental observations.
Topics: Abnormalities, Drug-Induced; Animals; Epilepsy; Female; Fetus; Folic Acid; Folic Acid Deficiency; Ha | 1974 |
Epilepsy in the elderly.
Topics: Age Factors; Aged; Angiography; Brain Neoplasms; Cerebrovascular Disorders; Dementia; Electroencepha | 1974 |
Side effects of clonazepam therapy.
Topics: Adolescent; Adult; Aggression; Ataxia; Benzodiazepinones; Clonazepam; Drug Interactions; Epilepsy; E | 1974 |
[Phenytoin (5,5-diphenylhydantoin) hypersensitivity presenting a clinical picture of scarlatiniform erythroderma].
Topics: Child; Dermatitis, Exfoliative; Drug Hypersensitivity; Epilepsy; Female; Hematopoietic System; Human | 1966 |
The oxytalan connective tissue fibres in gingival hyperplasia in patients treated with sodium diphenylhydantoin.
Topics: Connective Tissue; Epilepsy; Gingival Hyperplasia; Phenytoin | 1967 |
Diphenylhydantoin intoxication and cerebrospinal fluid protein.
Topics: Adenosine Triphosphatases; Adult; Cerebellar Ataxia; Cerebrospinal Fluid Proteins; Epilepsy; Female; | 1968 |
The effect of 5,5-diphenylhydantoin (dilantin) on fibroblast-like cells in culture.
Topics: Epilepsy; Fibroblasts; Gingival Hyperplasia; Phenytoin | 1969 |
Diphenylhydantoin therapy.
Topics: Adolescent; Drug Eruptions; Epilepsy; Erythema Multiforme; Humans; Phenytoin | 1970 |
Current concepts--status epilepticus.
Topics: Aldehydes; Anesthetics; Anticonvulsants; Barbiturates; Bromides; Epilepsy; Humans; Phenytoin; Tranqu | 1970 |
[Outpatient therapy of epilepsy].
Topics: Anticonvulsants; Barbiturates; Depression, Chemical; Drug Eruptions; Drug Hypersensitivity; Epilepsi | 1970 |
Brain synapses. An in vitro model for the study of seizures.
Topics: Adenosine Triphosphatases; Animals; Biological Transport; Brain; Disease Models, Animal; Electroence | 1972 |
Radiologic bone changes and hypocalcemia with anticonvulsant therapy in epilepsy.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Back Pain; Calcium; Carbamazepine; D | 1972 |
Severe cutaneous reactions to phenytoin.
Topics: Child; Drug Eruptions; Epilepsy; Female; Humans; Male; Phenytoin | 1973 |
Paroxysmal choreoathetosis. Report of Chinese cases.
Topics: Adult; Age Factors; Athetosis; China; Electroencephalography; Epilepsy; Female; Humans; Huntington D | 1973 |
Carbamazepine as an anticonvulsant: a pilot study.
Topics: Administration, Oral; Adult; Anticonvulsants; Carbamazepine; Drug Eruptions; Epilepsy; Eye Movements | 1974 |
Peripheral neuropathy in long-term diphenylhydantoin therapy.
Topics: Adolescent; Adult; Child; Electromyography; Electrophysiology; Epilepsy; Humans; Middle Aged; Muscle | 1968 |
Inhibitory effect of diphenylhydantoin on the feedback control of corticotrophin release.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; | 1969 |
The effect of tegretol on some elementary neuronal mechanisms.
Topics: Animals; Carbamazepine; Cats; Dibenzazepines; Epilepsy; Phenytoin; Synapses; Synaptic Transmission; | 1969 |
Effect of diphenylhydantoin on the metabolism of metyrapone and release of ACTH in man.
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Depression, Chemical; Epilepsy; Humans; Hydr | 1969 |
[American neurology for Swedish use].
Topics: Adrenocorticotropic Hormone; Ampicillin; Brain Diseases; Cerebrovascular Disorders; Contrast Media; | 1968 |
Peripheral neuropathy in long-term diphenylhydantoin therapy.
Topics: Adult; Aged; Epilepsy; Female; Humans; Male; Middle Aged; Neuritis; Neurologic Examination; Peripher | 1967 |
Dilantin and metyrapone: a clinically significant example of enzyme induction.
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Animals; Depression, Chemical; Endoplasmic R | 1970 |
Drug treatment of convulsive disorders.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; E | 1972 |
Progressive myoclonus with epilepsy.
Topics: Adult; Child; Chlordiazepoxide; Epilepsy; Female; Humans; Inclusion Bodies; Lipidoses; Myoclonic Cer | 1972 |
Diphenylhydantoin-induced cerebellar degeneration.
Topics: Adolescent; Cerebellar Ataxia; Cerebellar Diseases; Child; Electroencephalography; Epilepsy; Female; | 1972 |
[Hydantoins and neurologic complications].
Topics: Adolescent; Brain Diseases; Cerebrospinal Fluid Proteins; Drug Hypersensitivity; Epilepsy; Humans; H | 1973 |
[Epilepsy and perinatal injury].
Topics: Adolescent; Adrenocorticotropic Hormone; Barbiturates; Birth Injuries; Brain Diseases; Cerebral Hemo | 1973 |
Peripheral nerve function in long-term therapy with diphenylhydantoin. A clinical and electrophysiologic correlation.
Topics: Adult; Aged; Carbamazepine; Electric Stimulation; Electromyography; Epilepsy; Ethosuximide; Evoked P | 1974 |
Nerve conduction velocity in patients on long-term diphenylhydantoin therapy.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Drug Therapy, Combination; Electrodiagnosis; Epilepsy; | 1974 |
Iatrogenic disorders in epilepsy.
Topics: Adrenal Insufficiency; Anemia, Macrocytic; Animals; Anticonvulsants; Cats; Cerebellar Diseases; Drug | 1970 |
[Anticonvulsants and vitamin D metabolism (author's transl)].
Topics: Animals; Anticonvulsants; Avitaminosis; Body Weight; Calcium; Calcium Radioisotopes; Cholecalciferol | 1974 |
Neonatal effects of maternal treatment with the anticonvulsant drug diphenylhydantoin.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Blood Coagulation Disorders; Epilepsy; Female; Human | 1971 |
Drugs in management of hyperkinetic and perceptually handicapped children.
Topics: Anticonvulsants; Central Nervous System Stimulants; Child; Child, Preschool; Chlordiazepoxide; Chlor | 1968 |
Sulthiame (Ospolot) as inhibitor of diphenylhydatoin metabolism.
Topics: Anticonvulsants; Carbon Isotopes; Chromatography, Thin Layer; Epilepsy; Humans; Phenytoin; Radionucl | 1968 |
"Dilatin" overdosage.
Topics: Anticonvulsants; Ataxia; Brain Neoplasms; Carbamazepine; Diagnosis, Differential; Dibenzazepines; Ep | 1968 |
Epilepsy.
Topics: Adult; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, T | 1969 |
Drug treatment of epilepsy in childhood.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diazepam; Epilepsy; Epilepsy, Absence; Epil | 1969 |
[Treatment of partial epilepsies with a sultiamum containing combination].
Topics: Adolescent; Adult; Aggression; Anticonvulsants; Barbiturates; Caffeine; Child; Electroencephalograph | 1969 |
Diphenylhydantoin.
Topics: Affective Symptoms; Arrhythmias, Cardiac; Ataxia; Carbamazepine; Central Nervous System Diseases; Ch | 1971 |
Anticonvulsant drugs in idiopathic epilepsy.
Topics: Acetazolamide; Anticonvulsants; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Hydantoins; Mepho | 1970 |
A comprehensive scheme for the evaluation of anticonvulsant concentrations in blood using thin-layer chromatography.
Topics: Acetazolamide; Anticonvulsants; Benzazepines; Carbamazepine; Chlordiazepoxide; Chromatography, Thin | 1971 |
[Medical treatment of epilepsy].
Topics: Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Hydantoins; | 1971 |
Utilization of a microprogrammable computer for statistical analyses of data from a large epileptic patient population. I. Techniques and preliminary results.
Topics: Adolescent; Adult; Computers; Data Display; Epilepsy; Factor Analysis, Statistical; Humans; Informat | 1972 |
Serum -glytamyl transpeptidase activity in liver disease.
Topics: Acyltransferases; Adolescent; Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Barbit | 1972 |
Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects.
Topics: Acetates; Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Dibenzazepines; Electroencephalog | 1972 |
Diphenylhydantoin-induced asterixis. A clinical study.
Topics: Ataxia; Electroencephalography; Electromyography; Epilepsy; Female; Humans; Male; Middle Aged; Nysta | 1974 |
A method for shifting from oral to intramuscular diphenylhydantoin administration.
Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Injections, | 1974 |
Letter: Sleep epilepsy.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Delayed-Action Preparations; Dextroamphetam | 1974 |
Status epilepticus.
Topics: Diazepam; Epilepsy; Humans; Hypocalcemia; Hypoglycemia; Magnesium Deficiency; Paraldehyde; Phenobarb | 1974 |
Letter: Anticonvulsants and vitamin D metabolism.
Topics: Child; Drug Therapy, Combination; Epilepsy; Humans; Osteomalacia; Phenobarbital; Phenytoin; Primidon | 1974 |
[Antiepileptic drugs and congenital malformations. Interaction between antiepileptic drugs and contraceptives?].
Topics: Abnormalities, Drug-Induced; Contraceptives, Oral; Drug Interactions; Epilepsy; Female; Humans; Infa | 1974 |
Emergency testing and routine monitoring of therapeutic drugs in a comprehensive analytical system.
Topics: Adolescent; Amobarbital; Chromatography, Gas; Chromatography, Thin Layer; Electroencephalography; Ep | 1974 |
Serum immunoglobulins in epilepsy.
Topics: Adult; Drug Therapy, Combination; Epilepsy; Erythrocytes; Female; Folic Acid; Humans; Immunoglobulin | 1974 |
Do anticonvulsants have a teratogenic effect?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Cleft Palate; Congenital | 1974 |
[Plasma diphenylhydantoin concentration in epileptic patients].
Topics: Drug Interactions; Epilepsy; Humans; Phenobarbital; Phenytoin | 1974 |
[Diphenylhydantoin poisoning due to diphenylhydantoin-isoniazid interaction].
Topics: Adult; Cognition Disorders; Drug Interactions; Epilepsy; Fatigue; Humans; Isoniazid; Male; Middle Ag | 1974 |
Drug estimation in the treatment of epilepsy.
Topics: Adult; Biological Availability; Dose-Response Relationship, Drug; Epilepsy; Humans; Kinetics; Male; | 1974 |
[Scleroderma developing during treatment of ictal stupor with diphenylhydantoin].
Topics: Adult; Epilepsy; Female; Humans; Phenytoin; Scleroderma, Localized | 1974 |
[Considerations and research on febrile convulsions].
Topics: Anticonvulsants; Brain Diseases; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencepha | 1974 |
[Special viewpoints in the treatment with anticonvulsants in childhood. Value of determination of serum level of anticonvulsants in the treatment of seizures].
Topics: Adolescent; Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Male; Phenobarbital; Phenyt | 1974 |
Iatrogenic nutritional effects of anticonvulsants.
Topics: Adolescent; Adult; Anticonvulsants; Blood Coagulation Disorders; Bone Diseases; Child; Child, Presch | 1974 |
Enhancement of diphenylhydantoin-induced anticonvulsant activity of a shaking stress.
Topics: Animals; Anticonvulsants; Drug Interactions; Electroshock; Epilepsy; Female; Male; Mice; Phenoxybenz | 1974 |
Letter: Effect of phenytoin on serum phenobarbitone levels.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Huma | 1974 |
Chuckling and glugging seizures at night -- sylvian spike epilepsy.
Topics: Child; Clonazepam; Electroencephalography; Epilepsy; Humans; Laughter; Male; Migraine Disorders; Phe | 1974 |
Sympodia.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abnormalities, Severe Teratoid; Autopsy; Epile | 1974 |
Effects of age, sex, obesity, and pregnancy on plasma diphenylhydantoin levels.
Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Chromatography, Gas; Dose-Response Relationshi | 1974 |
Urinary excretion of diphenylhydantoin metabolites in newborn infants.
Topics: Chromatography, Gas; Epilepsy; Female; Half-Life; Humans; Infant, Newborn; Maternal-Fetal Exchange; | 1974 |
Diphenylhydantoin toxicity: dose-dependent blood dyscrasia.
Topics: Adult; Amenorrhea; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Hypothermia; Hypothyr | 1974 |
Letter: Diphenylhydantoin and blood dyscrasias.
Topics: Epilepsy; Hematologic Diseases; Humans; Phenytoin | 1974 |
Augmentation of cerebellar Purkinje cell discharge rate after diphenylhydantoin.
Topics: Acetazolamide; Action Potentials; Cerebellum; Electroencephalography; Epilepsy; Phenobarbital; Pheny | 1972 |
Effects of diphenylhydantoin and other antiepileptic drugs on epileptiform activity and Purkinje cell discharge rates.
Topics: Acetazolamide; Action Potentials; Animals; Anticonvulsants; Blood Pressure; Cats; Cerebellum; Electr | 1972 |
Inadvertent chronic diphenylhydantoin intoxication in a teenage girl.
Topics: Adolescent; Epilepsy; Female; Humans; Medication Errors; Phenytoin; Self Medication | 1972 |
Incidence of diphenylhydantoin gingival hyperplasia.
Topics: Adolescent; Adult; Aged; Epilepsy; Gingival Hyperplasia; Humans; Middle Aged; Oral Hygiene; Phenytoi | 1972 |
Influence of diphenylhydantoin and phenobarbital on intestinal calcium transport in the rat.
Topics: Animals; Binding, Competitive; Calcium; Calcium Isotopes; Calcium Metabolism Disorders; Epilepsy; In | 1972 |
[Epileptic children as patients in a systematic school dental service].
Topics: Adolescent; Anticonvulsants; Child; Dental Plaque; Epilepsy; Female; Gingiva; Gingival Hyperplasia; | 1973 |
Chronic hydantoin intoxication: case report.
Topics: Adult; Cerebellar Ataxia; Cognition Disorders; Epilepsy; Female; Humans; Nystagmus, Pathologic; Phen | 1972 |
Anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregna | 1973 |
One daily dose of diphenylhydantoin (DPH) to patients with epilepsy.
Topics: Administration, Oral; Epilepsy; Half-Life; Humans; Phenytoin; Time Factors | 1972 |
The effects of some anticonvulsant drugs on cobalt-induced epilepsy.
Topics: Animals; Cobalt; Electroencephalography; Epilepsy; Ethosuximide; Evaluation Studies as Topic; Fronta | 1973 |
Experiences with Bivotril in treatment of epilepsy--particularly minor motor epilepsy--in mentally retarded children.
Topics: Acetazolamide; Adolescent; Adult; Anticonvulsants; Benzodiazepinones; Child; Child, Preschool; Chlor | 1973 |
A clinical trial with clonazepam (Ro 5-4023).
Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Benzodiazepinones; Carbamazepine; Child; Chloroben | 1973 |
[Hydantoin-induced hyperplasia].
Topics: Adolescent; Adult; Child; Dental Plaque; Epilepsy; Female; Gingival Hyperplasia; Gingivectomy; Human | 1973 |
Post-rotational nystagmus. An unreliable sign of diphenylhydantoin toxicity.
Topics: Chromatography, Thin Layer; Epilepsy; Humans; Nystagmus, Pathologic; Phenytoin; Rotation | 1973 |
Editorial: Management of status epilepticus.
Topics: Barbiturates; Diazepam; Epilepsy; Humans; Paraldehyde; Phenytoin | 1974 |
Anticonvulsant drug-serum levels in psychiatric patients with seizure disorders. Effects of certain psychotropic drugs.
Topics: Chlorpromazine; Chromatography, Gas; Diazepam; Drug Interactions; Epilepsy; Humans; Mental Disorders | 1974 |
[Acute leukemia induced by diphenylhydantoin? Apropos of 4 cases].
Topics: Adult; Bone Marrow; Drug Therapy, Combination; Epilepsy; Female; Humans; Leukemia, Lymphoid; Lung; L | 1973 |
One daily dose of diphenylhydantoin for patients with epilepsy.
Topics: Administration, Oral; Adolescent; Adult; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Tim | 1974 |
Root abnormalities in epileptics and the inhibition of parathyroid hormone induced bone resorption by diphenyl hydantoin in tissue culture.
Topics: Adult; Animals; Bone Resorption; Culture Techniques; Epilepsy; Humans; Mice; Parathyroid Hormone; Pe | 1974 |
Editorial: Plasma diphenylhydantoin levels.
Topics: Adult; Age Factors; Child; Drug Interactions; Epilepsy; Female; Humans; Liver; Male; Mixed Function | 1974 |
[Epileptic children as patients in a systematic school dental service].
Topics: Adolescent; Child; Denmark; Epilepsy; Gingival Hyperplasia; Humans; Phenytoin; School Dentistry | 1973 |
Initial and maintenance dose of vitamin D2 in the treatment of anticonvulsant osteomalacia.
Topics: Adult; Alkaline Phosphatase; Bone and Bones; Calcium; Epilepsy; Ergocalciferols; Female; Humans; Mal | 1974 |
[An autopsy case of epilepsy complicated with dilantin gingival hyperplasia (author's transl)].
Topics: Adult; Autopsy; Epilepsy; Gingival Hyperplasia; Humans; Male; Phenytoin | 1974 |
Effective treatment of Dilantin gingival hyperplasia.
Topics: Adolescent; Adult; Dentures; Epilepsy; Female; Gingival Hyperplasia; Gingivectomy; Humans; Male; Phe | 1973 |
Penicillin-induced epileptogenic foci. I. Time course and the anticonvulsant effects of diphenylhydantoin and diazepam.
Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Cerebral Ventricles; Diazepam; Dose-Response Relati | 1974 |
[Dental treatment for patients with epileptic seizures].
Topics: Adolescent; Dental Care; Denture Repair; Dentures; Epilepsy; Female; Gingival Hyperplasia; Humans; M | 1974 |
Diazepam as an oral long-term anticonvulsant for epileptic mental patients.
Topics: Amobarbital; Anticonvulsants; Diazepam; Epilepsy; Evaluation Studies as Topic; Female; Humans; Long- | 1972 |
A medical and social survey of 231 children with seizures.
Topics: Adolescent; Attitude to Health; Child; Child Behavior Disorders; Child, Preschool; Electroencephalog | 1972 |
The density and ultrastructure of the Purkinje cells following diphenylhydantoin treatment in animals and man.
Topics: Animals; Autopsy; Cell Count; Cerebellum; Epilepsy; Epilepsy, Tonic-Clonic; Female; Haplorhini; Huma | 1972 |
The action of some anticonvulsant drugs on cobalt-induced epilepsy and on the bemegride threshold in alert cats.
Topics: Animals; Anticonvulsants; Bemegride; Carbamazepine; Cats; Cobalt; Diazepam; Electroencephalography; | 1972 |
Sensory and motor nerve conduction velocity in long-term diphenylhydantoin therapy.
Topics: Adolescent; Adult; Epilepsy; Female; Humans; Long-Term Care; Male; Median Nerve; Middle Aged; Motor | 1972 |
Suppressant effects of diphenylhydantoin on the cortical epileptogenic focus.
Topics: Animals; Cats; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Electroencephalography | 1973 |
[A new case of the so-called "hydantoin perniciosa"].
Topics: Anemia, Pernicious; Epilepsy; Female; Humans; Middle Aged; Phenytoin | 1972 |
Potential hazards of hydantoin use.
Topics: Epilepsy; Female; Humans; Immunity, Cellular; Immunoglobulins; Immunologic Deficiency Syndromes; Phe | 1972 |
Effect of dosage increments on blood phenytoin concentrations.
Topics: Administration, Oral; Dose-Response Relationship, Drug; Epilepsy; Humans; Phenytoin | 1972 |
[Apnea and heart arrest following distraneurin therapy. Clinical, neurophysiological and neuropathological aspects].
Topics: Adult; Apnea; Basal Ganglia; Cerebral Cortex; Chlormethiazole; Drug Synergism; Electroencephalograph | 1972 |
[Hydantoins today].
Topics: Arrhythmias, Cardiac; Carbohydrate Metabolism; Central Nervous System; Diabetic Neuropathies; Epilep | 1972 |
Effectiveness of single daily doses of diphenylhydantoin.
Topics: Epilepsy; Evaluation Studies as Topic; Humans; Motor Skills; Neurologic Examination; Phenytoin; Refl | 1972 |
Tonic seizures induced by movement.
Topics: Adolescent; Electroencephalography; Epilepsy; Humans; Male; Movement; Neurologic Examination; Phenyt | 1972 |
Relationships between serum and cerebrospinal fluid anticonvulsant drug and folic acid concentrations in epileptic patients.
Topics: Adult; Chromatography, Gas; Epilepsy; Female; Folic Acid; Humans; Male; Phenobarbital; Phenytoin; Pr | 1972 |
Toxic encephalopathy with seizures secondary to ingestion of composition C-4. A clinical and electroencephalographic study.
Topics: Adult; Brain Diseases; Electroencephalography; Epilepsy; Explosions; Humans; Male; Military Medicine | 1972 |
The simultaneous determination of multiple anticonvulsant drug levels by gas-liquid chromatography. Method and clinical application.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Chromatography, Gas; Epilepsy; Ethosuxi | 1972 |
[Diurnal rhythm of plasma cortisol in epileptic patients].
Topics: Adult; Age Factors; Circadian Rhythm; Epilepsy; Female; Humans; Hydrocortisone; Male; Middle Aged; P | 1972 |
[Nutritional and experimental studies on folic acid deficiency due to anticonvulsants].
Topics: Adult; Anemia, Macrocytic; Animals; Anticonvulsants; Diet; Epilepsy; Folic Acid; Folic Acid Deficien | 1972 |
[Differences between individuals in human pharmacokinetics. Clinical significance].
Topics: Binding Sites; Desipramine; Epilepsy; Female; Humans; Male; Nortriptyline; Pharmacogenetics; Phenyto | 1972 |
Clinical and physiological effects of stimulation of the paleocerebellum in humans.
Topics: Adult; Cerebellum; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy; Ep | 1973 |
Use of diphenylhydantoin.
Topics: Epilepsy; Humans; Injections, Intravenous; Phenytoin | 1973 |
Use of diphenylhydantoin.
Topics: Epilepsy; Humans; Injections, Intravenous; Nystagmus, Pathologic; Phenytoin | 1973 |
Follow-up of epileptic outpatients.
Topics: Adolescent; Adult; Aged; Educational Status; Employment; Epilepsy; Female; Follow-Up Studies; Humans | 1973 |
[Epilepsy and pregnancy].
Topics: Abortion, Spontaneous; Anticonvulsants; Birth Weight; Epilepsy; Female; Humans; Infant, Newborn; Inf | 1973 |
Leucine aminopeptidase isoenzyme changes after treatment with anticonvulsant drugs.
Topics: Blood Protein Electrophoresis; Blood Proteins; Epilepsy; Humans; Isoenzymes; Jaundice; Leucyl Aminop | 1973 |
[Phenytoin--blood levels and clinical aspects].
Topics: Administration, Oral; Drug Interactions; Epilepsy; Humans; Isoniazid; Phenytoin; Protein Binding; Ti | 1973 |
Effects of diphenylhydantoin on activity of rat cerebellar Purkinje cells.
Topics: Action Potentials; Animals; Behavior, Animal; Blood Pressure; Dose-Response Relationship, Drug; Elec | 1973 |
Epilepsy and pregnancy: a report from the Oxford Record Linkage Study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Child; Congenital Abnormalities; Drug S | 1973 |
Abdominal epilepsy.
Topics: Abdomen; Carbamazepine; Colic; Diagnosis, Differential; Electroencephalography; Epilepsy; Humans; Ma | 1973 |
Diencephalic autonomic epilepsy caused by a neoplasm.
Topics: Astrocytoma; Autonomic Nervous System; Brain Neoplasms; Diencephalon; Epilepsy; Female; Humans; Infa | 1973 |
Control rate in diphenylhydantoin therapy.
Topics: Epilepsy; Evaluation Studies as Topic; Humans; Phenytoin | 1973 |
[Ambulatory extended care for the child with seizures].
Topics: Adolescent; Age Factors; Ambulatory Care; Child; Child, Preschool; Diazepam; Epilepsy; Ethosuximide; | 1973 |
Serum diphenylhydantoin, triglyceride and cholesterol concentration.
Topics: Adult; Cholesterol; Epilepsy; Female; Humans; Hyperlipidemias; Male; Middle Aged; Phenytoin; Triglyc | 1973 |
Effect of diphenylhydantoin therapy on folate metabolism of mentally retarded epileptics.
Topics: Adolescent; Adult; Anticonvulsants; Azo Compounds; Child; Epilepsy; Female; FIGLU Test; Folic Acid; | 1973 |
Pheneturide, a more potent liver enzyme inducer in man than phenobarbitone?
Topics: Adipates; Anticonvulsants; Enzyme Induction; Epilepsy; Female; Humans; Liver; Male; Phenobarbital; P | 1973 |
Diphenylhydantoin-induced gingival hyperplasia: its relationship to dose and serum level.
Topics: Adolescent; Adult; Age Factors; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Gingival | 1973 |
[Diphenylhydantoin poisoning induced by isoniazide. A further case].
Topics: Child; Drug Interactions; Electroencephalography; Epilepsy; Humans; Isoniazid; Male; Neurologic Mani | 1973 |
Primidone, diphenylhydantoin and phenobarbital. Aspects of acute and chronic toxicity.
Topics: Ataxia; Chromatography, Gas; Drug Tolerance; Epilepsy; Humans; Nystagmus, Pathologic; Phenobarbital; | 1973 |
Plasma diphenylhydantoin values after oral and intramuscular administration of diphenylhydantoin.
Topics: Administration, Oral; Dose-Response Relationship, Drug; Epilepsy; Humans; Injections, Intramuscular; | 1973 |
Inadequate serum levels after intramuscular administration of diphenylhydantoin.
Topics: Administration, Oral; Animals; Child; Epilepsy; Evaluation Studies as Topic; Humans; Injections, Int | 1973 |
Epileptic pain. An uncommon manifestation with localizing value.
Topics: Adenocarcinoma; Adult; Brain Neoplasms; Cerebral Angiography; Diazepam; Epilepsy; Female; Humans; Ma | 1973 |
Rickets precipitated by anticonvulsant drugs in a child receiving prophylactic vitamin D.
Topics: Adolescent; Alkaline Phosphatase; Calcium; Epilepsy; Female; Humans; Ilium; Phenobarbital; Phenytoin | 1973 |
Preliminary observations of serum carbamazepine concentration in epileptic patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Humans; Male; Mid | 1973 |
Diphenylhydantoin in children. Pharmacology and efficacy.
Topics: Age Factors; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Evaluation Studies | 1973 |
[Genetic questionnaire. Genetic counseling for a patient with the complex association of G-6-PD deficiency, Gronblad-Strandberg syndrome (pseudo-xanthoma elasticum) and epilepsy].
Topics: Adult; Epilepsy; Favism; Genetic Counseling; Glucosephosphate Dehydrogenase Deficiency; Humans; Kidn | 1973 |
The role of antiepileptic blood levels in the treatment of patients with epilepsy.
Topics: Adult; Drug Therapy, Combination; Epilepsy; Female; Humans; Middle Aged; Phenobarbital; Phenytoin; P | 1973 |
Diphenylhydantoin and selected congenital malformations.
Topics: Abnormalities, Drug-Induced; Adult; Birth Weight; Congenital Abnormalities; Epilepsy; Female; Fetus; | 1973 |
Editorial: Teratogenesis and antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Congenital Abnormalities; Epi | 1973 |
Failure to observe dosage instructions in patients with epilepsy. The short-term effect of a daily dispenser.
Topics: Adolescent; Adult; Chromatography, Gas; Drug Packaging; Drug Therapy, Combination; Epilepsy; Female; | 1973 |
Abnormalities in liver function tests during long-term diphenylhydantoin therapy in epileptic out-patients.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Bilirubin; Calcium; Epilepsy; F | 1973 |
[Editorial: Antiepileptic agents--folic acid].
Topics: Anemia, Macrocytic; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; P | 1973 |
The influence of phenobarbital and diphenylhydantoin on some blood cation transport systems in epileptics.
Topics: Adolescent; Adult; Aged; Biological Transport; Brain; Child; Child, Preschool; Electrolytes; Epileps | 1973 |
A rapid method for the estimation of anti-epileptic drugs in blood serum by gas-liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Epilepsy; Ethosuximide; Evaluation Studies as T | 1973 |
The teratological effects of anticonvulsants and the effects on pregnancy and birth.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cleft Lip; Cleft Palate; Cyclohe | 1973 |
Lymphocytosis in the first-trimester placenta of a mother taking diphenylhydantoin.
Topics: Abortion, Induced; Adult; Epilepsy; Female; Humans; Lymphocytosis; Phenytoin; Placenta; Placenta Dis | 1973 |
The orienting reflex in epilepsy: electrographic data concerning the effect of antiepileptic treatment upon the interictal changes in the orienting reflex. Human data.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Cardiovascular System; Child; Drug Combinations; Electroc | 1973 |
[Editorial: Teratogenic risk of the anti-epileptic therapeutics].
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Epilepsy; Female; Humans; Mice; Phenytoin; Ra | 1973 |
Influence of phenobarbital and diphenylhydantoin on plasma carbamazepine levels in patients with epilepsy.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Depression, Chemical; Drug Therapy, Combination; Epil | 1973 |
Effect of anticonvulsive drugs on folate absorption and the cerebrospinal folate pump.
Topics: Adolescent; Adult; Aged; Carbamazepine; Depression, Chemical; Epilepsy; Female; Folic Acid; Folic Ac | 1973 |
[Folic acid and folate values in plasma and whole blood].
Topics: Acute Disease; Barbiturates; Contraceptives, Oral; Epilepsy; Ethanol; Female; Folic Acid; Folic Acid | 1973 |
Minor epileptic status with contractures.
Topics: Child; Contracture; Electroencephalography; Epilepsy; Female; Humans; Intelligence; Phenytoin; Predn | 1973 |
[Complications of medical therapy for epilepsy in children and adolescents].
Topics: Anticonvulsants; Child; Diplopia; Drug Hypersensitivity; Drug Therapy, Combination; Epilepsy; Headac | 1973 |
Correlation of anticonvulsant levels in human plasma and epileptogenic brain.
Topics: Animals; Brain; Cerebral Cortex; Electroencephalography; Epilepsy; Frontal Lobe; Humans; Phenobarbit | 1973 |
[Incompatibility of dilantin with isonicotinic acid hydrazides].
Topics: Adult; Drug Incompatibility; Epilepsy; Female; Humans; Isoniazid; Male; Middle Aged; Phenytoin; Trig | 1973 |
Clonazepam in the treatment of epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepinones; Chlorobenzenes; Chromatography, Gas; Drug Int | 1973 |
Diphenylhydantoin dosage.
Topics: Adolescent; Adult; Age Factors; Body Weight; Child; Chromatography, Gas; Drug Interactions; Epilepsy | 1973 |
[Hemostasis in epileptic patients treated with anticonvulsant drugs].
Topics: Adolescent; Adult; Aged; Blood Coagulation Disorders; Blood Coagulation Factors; Child; Drug Evaluat | 1973 |
Plasma disappearance of transplacentally transferred diphenylhydantoin in the newborn studied by mass fragmentography.
Topics: Adult; Deuterium; Epilepsy; Female; Half-Life; Humans; Infant, Newborn; Kinetics; Male; Mass Spectro | 1974 |
Emergency management of the patient with seizures. 1. Generalized status epilepticus.
Topics: Airway Obstruction; Anesthesia, General; Anticonvulsants; Blood Pressure Determination; Blood Specim | 1974 |
The influence of diphenylhydantoin on primidone metabolism.
Topics: Adult; Biotransformation; Chromatography, Gas; Drug Interactions; Enzyme Induction; Epilepsy; Female | 1974 |
[Letter: Diphenylhydantoins and teratogenic hazards].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications | 1974 |
[Letter: Teratogenic hazards in antiepileptic therapy].
Topics: Abnormalities, Drug-Induced; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Preg | 1974 |
Serum copper levels and diphenylhydantoin.
Topics: Ceruloplasmin; Chromatography, Gas; Copper; Drug Interactions; Epilepsy; Humans; Phenytoin; Spectrum | 1974 |
Brain damage after lithium and phenytoin.
Topics: Brain Diseases; Cerebellar Ataxia; Epilepsy; Female; Humans; Lithium; Phenytoin; Purkinje Cells | 1974 |
Calcium metabolism in elderly epileptic patients during anticonvulsant therapy.
Topics: Aged; Alkaline Phosphatase; Calcium; Cerebrovascular Disorders; Drug Therapy, Combination; Epilepsy; | 1974 |
Infants exposed in utero to antiepileptic drugs. A prospective study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro | 1974 |
Letter: Anticonvulsant drugs and congenital abnormalities.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetus; Fingers; Humans; Infant; Nail | 1974 |
Pharmacology for the pediatrician. Noncompliance contributing to apparent drug failure in status epilepticus.
Topics: Anticonvulsants; Benzodiazepinones; Child; Chlorobenzenes; Diazepam; Epilepsy; Ethosuximide; Female; | 1974 |
Ulcerative colitis, colitic spondylitis and associated apical pulmonary fibrosis.
Topics: Arthritis; Barium Sulfate; Colitis, Ulcerative; Epilepsy; Humans; Male; Middle Aged; Phenytoin; Pulm | 1974 |
Intravenous glucose tolerance during treatment with phenytoin.
Topics: Blood Glucose; Epilepsy; Glucose Tolerance Test; Humans; Insulin; Phenytoin | 1974 |
Decrease in serum diphenylhydantoin levels after withdrawal of phenobarbital in epileptics treated with both drugs.
Topics: Child; Child, Preschool; Chromatography, Gas; Epilepsy; Female; Humans; Male; Phenobarbital; Phenyto | 1974 |
Serum levels of diphenylhydantoin and phenobarbital in epileptic children receiving diphenylhydantoin, phenobarbital and-or mysoline.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; Phenytoi | 1974 |
Serum anticonvulsant concentrations in epileptic patients with mental symptoms. A preliminary report.
Topics: Adolescent; Adult; Aged; Epilepsy; Female; Humans; Intelligence; Male; Mental Disorders; Middle Aged | 1974 |
[Ethnic differences in serum phenytoin levels].
Topics: Adolescent; Adult; Child; Child, Preschool; Denmark; Epilepsy; Ethnicity; Female; Greenland; Humans; | 1974 |
Clinical significance of generic inequivalence of three different pharmaceutical preparations of phenytoin.
Topics: Acids; Adult; Biopharmaceutics; Epilepsy; Female; Humans; Male; Middle Aged; Particle Size; Phenytoi | 1974 |
Development of anticonvulsant osteomalacia in epileptic patients on phenytoin treatment.
Topics: Adult; Aged; Alkaline Phosphatase; Bone and Bones; Calcium; Epilepsy; Female; Humans; Male; Middle A | 1974 |
Editorial: Congenital malformations and antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fe | 1974 |
Effect of diphenylhydantoin on hepatic drug hydroxylation.
Topics: Adult; Antipyrine; Bilirubin; Colorimetry; Creatinine; Epilepsy; Half-Life; Humans; Hydroxylation; J | 1974 |
Inhibition of high-affinity glial uptake of 14C-glutamate by folate.
Topics: Animals; Carbon Radioisotopes; Epilepsy; Extracellular Space; Folic Acid; Ganglia, Spinal; Glutamate | 1974 |
Isolation of 1,4-androstadiene-3,17-dione from urine of an epileptic boy.
Topics: Adolescent; Androstenes; Chromatography, Gas; Chromatography, Paper; Chromatography, Thin Layer; Cir | 1974 |
Stress convulsions.
Topics: Adolescent; Adult; Affect; Age Factors; Child; Electroencephalography; Epilepsy; Evaluation Studies | 1974 |
Movement disorder as a manifestation of diphenylhydantoin intoxication.
Topics: Adult; Ataxia; Athetosis; Chorea; Epilepsy; Female; Humans; Middle Aged; Nystagmus, Pathologic; Phen | 1974 |
Delivery of anticonvulsant drug therapy in epileptic patients assessed by plasma level analyses.
Topics: Adolescent; Adult; Child; Chromatography, Gas; Drug Therapy; Electroencephalography; Epilepsy; Human | 1974 |
[Treatment of epilepsy with tegretol (5-carbamyl-5H-dibenzo (b,f) azepine)].
Topics: Adolescent; Adult; Anticonvulsants; Azepines; Child; Chlordiazepoxide; Electroencephalography; Epile | 1965 |
Electrophysiological studies of the action of intravenous diphenylhydantoin (Dilantin).
Topics: Animals; Cerebral Cortex; Electroencephalography; Epilepsy; Haplorhini; Injections, Intravenous; Phe | 1966 |
The development of Hodgkin's disease and lymphoma during anticonvulsant therapy.
Topics: Adult; Aged; Anticonvulsants; Child; Epilepsy; Epilepsy, Absence; Epilepsy, Post-Traumatic; Epilepsy | 1966 |
Lack of significant binding of L-triiodothyronine by thyroxine-binding globulin in vivo as demonstrated by acute disappearance of 131-I-labeled triiodothyronine.
Topics: Adolescent; Adult; Aged; Epilepsy; Estrogens; Female; Hepatitis; Humans; Hyperthyroidism; Hypothyroi | 1966 |
Controlled evaluation of primidone and diphenyllhydantoin sodium. Comparative anticonvulsant efficacy and toxicity in children.
Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; Human | 1968 |
[Status elepticus].
Topics: Barbiturates; Diazepam; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenytoin | 1967 |
[The treatment of epilepsy with falepsin. A report of the clinical experience gained].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Epilepsy; Epilepsy, Tonic-Clonic; | 1968 |
Precordial pain in an epileptic relic by dilantin.
Topics: Angina Pectoris; Diagnosis, Differential; Electrocardiography; Epilepsy; Female; Humans; Middle Aged | 1969 |
The metabolic significance of thyroxine-binding globulin. Studies in a family with decreased thyroxine-binding globulin.
Topics: Adolescent; Adult; Aged; Basal Metabolism; Blood Protein Disorders; Child; Epilepsy; Female; Humans; | 1969 |
Studies of anticonvulsant levels in epileptics. I. Serum diphenylhydantoin concentrations in a group of medically indigent outpatients.
Topics: Anticonvulsants; Barbiturates; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medical Indigency; Neurolog | 1969 |
Diphenylhydantoin as an anticonvulsant: protein binding and fluctuation of the serum and cerebrospinal fluid levels in forty mentally subnormal epileptics.
Topics: Epilepsy; Epilepsy, Tonic-Clonic; Humans; Intellectual Disability; Phenytoin; Protein Binding; Seizu | 1969 |
Effects of diphenylhydantoin (Dilantin) withdrawal on non-epileptics: preliminary report.
Topics: Adult; Aged; Electroencephalography; Epilepsy; Humans; Middle Aged; Phenytoin; Substance Withdrawal | 1970 |
Treatment of status epilepticus.
Topics: Child; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Humans; Male; P | 1970 |
Placental transfer and neonatal elimination of diphenylhydantoin.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Infant, Newborn; Lon | 1971 |
Unwanted effects of anticonvulsant drugs.
Topics: Child; Child, Preschool; Epilepsy; Humans; Long-Term Care; Phenytoin | 1971 |
Plasma protein binding, plasma concentrations, and effects of diphenylhydantoin in man.
Topics: Blood; Blood Proteins; Epilepsy; Epilepsy, Tonic-Clonic; Female; Humans; Hyperbilirubinemia; In Vitr | 1971 |
[Studies of the effect of 5,5-diphenylhydantoin on the bioelectric activity of the brain in epilepsy].
Topics: Administration, Oral; Adolescent; Adult; Brain; Electroencephalography; Epilepsy; Epilepsy, Absence; | 1971 |
[Results of treatment of epilepsy in children up to 14 years of age].
Topics: Adolescent; Age Factors; Barbiturates; Child; Child, Preschool; Diazepam; Drug Synergism; Electroenc | 1971 |
Epilepsia partialis continua.
Topics: Adult; Brain Diseases; Brain Stem; Electroencephalography; Epilepsies, Partial; Epilepsy; Hematoma, | 1971 |
Relationship between paroxysmal atrial tachycardia and paroxysmal cerebral discharges.
Topics: Anticonvulsants; Child, Preschool; Electrocardiography; Electroencephalography; Epilepsy; Humans; Hy | 1972 |
Folate deficiency after anticonvulsant drugs: an effect of hepatic enzyme induction?
Topics: Adipates; Adolescent; Anticonvulsants; Child; Enzyme Induction; Epilepsy; Female; Folic Acid; Folic | 1972 |
Unplanned pregnancy in an epileptic.
Topics: Amenorrhea; Contraceptives, Oral; Epilepsy; Ethinyl Estradiol; Female; Folic Acid; Gluconates; Human | 1972 |
[The diffusion of diphenylhydantoin across the cellophane membrane of the artificial kidney in a patient with uremia and epilepsy].
Topics: Cellophane; Diffusion; Epilepsy; Humans; Kidney Diseases, Cystic; Kidney Failure, Chronic; Kidneys, | 1972 |
Minor epileptic status.
Topics: Brain Diseases; Child; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Phenytoin; Primidone | 1972 |
[Teratogenic effect of phenytoin].
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Infant, Newborn; Phe | 1972 |
[Vitamins and medicines. New and complicated relations].
Topics: Arthritis, Rheumatoid; Aspirin; Drug Combinations; Drug Interactions; Epilepsy; Humans; Phenytoin; P | 1972 |
Immunological abnormalities and hydantoins.
Topics: Adult; Agammaglobulinemia; Antigens; Epilepsy; Female; Humans; Hydantoins; Immunity, Cellular; Immun | 1972 |
Antiepileptic drug concentrations in plasma. Clinical evaluation of 321 estimations in 237 unselected patients.
Topics: Carbamazepine; Chromatography, Gas; Chromatography, Thin Layer; Epilepsy; Humans; Methods; Phenobarb | 1972 |
Anticonvulsant hypocalcaemia.
Topics: Calcium; Epilepsy; Humans; Hypocalcemia; Phenobarbital; Phenytoin | 1972 |
Treatment of epilepsy in the light of determinations of the blood levels of anticonvulsants.
Topics: Adult; Child; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Primidone | 1972 |
Factors involved in an outbreak of phenytoin intoxication.
Topics: Australia; Calcium; Capsules; Epilepsy; Evaluation Studies as Topic; Humans; Lactose; Pharmaceutic A | 1972 |
Osteomalacia accompanying chronic anticonvulsant therapy.
Topics: Adolescent; Alkaline Phosphatase; Biopsy; Bone and Bones; Calcium; Epilepsy; Humans; Hydroxyproline; | 1972 |
Diphenylhydantoin and epilepsy management.
Topics: Administration, Oral; Epilepsy; Humans; Injections, Intramuscular; Injections, Intravenous; Phenobar | 1972 |
Coarse facies, calvarial thickening and hyperphosphatasia after anticonvulsants.
Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Child; Epilepsy; Facial Expression; Female; Humans; Ph | 1972 |
Drug interactions. 3. Therapeutic implications of enzyme induction.
Topics: Age Factors; Child; Child, Preschool; Drug Interactions; Drug Synergism; Enzyme Induction; Epilepsy; | 1972 |
[Speech disorders in children with cerebral convulsions].
Topics: Adolescent; Barbiturates; Carbamazepine; Drug Hypersensitivity; Electroencephalography; Epilepsy; Et | 1972 |
Diphenylhydantoin risks in children.
Topics: Child; Child, Preschool; Epilepsy; Humans; Medication Errors; Nervous System Diseases; Phenytoin; Su | 1972 |
Status epilepticus as a complication of intrathecal fluorescein. Case report.
Topics: Aged; Cerebrospinal Fluid Rhinorrhea; Contrast Media; Epilepsy; Fluoresceins; Glucocorticoids; Human | 1972 |
Abdominal epilepsy.
Topics: Abdomen; Age Factors; Child; Electroencephalography; Epilepsy; Humans; Nausea; Pain; Phenytoin; Prog | 1972 |
Febrile convulsions in early childhood.
Topics: Child, Preschool; Epilepsy; Fever; Hospitalization; Humans; Phenobarbital; Phenytoin; Seizures | 1972 |
Checking compliance of epileptic patients.
Topics: Adolescent; Anticonvulsants; Epilepsy; Humans; Phenobarbital; Phenytoin | 1972 |
Latent osteomalacia in epileptic patients on anticonvulsants.
Topics: Adult; Bone and Bones; Calcium; Epilepsy; Female; Humans; Male; Middle Aged; Minerals; Osteomalacia; | 1972 |
Folate deficiency in malnutrition, malabsorption, and during phenytoin treatment diagnosed by determination of serine synthesis in lymphocytes.
Topics: Adult; Aged; Anemia; Carbon Isotopes; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficie | 1972 |
Effect of a delayed-action phenytoin preparation on blood phenytoin concentration.
Topics: Chromatography, Gas; Delayed-Action Preparations; Epilepsy; Humans; Phenytoin | 1972 |
Epilepsy in multiple sclerosis.
Topics: Adolescent; Adult; Barbiturates; Basal Ganglia; Carbamazepine; Cerebral Cortex; Demyelinating Diseas | 1972 |
Serum folic acid and phenytoin levels in permanently hospitalized epileptic patients receiving anticonvulsant drug therapy.
Topics: Central Nervous System Diseases; Epilepsy; Folic Acid; Folic Acid Deficiency; Hospitalization; Human | 1971 |
Motor nerve conduction velocity during diphenylhydantoin intoxication.
Topics: Depression, Chemical; Electric Stimulation; Epilepsy; Evoked Potentials; Humans; Neural Conduction; | 1971 |
Concurrent administration of phenobarbital and diphenylhydantoin: lack of an interference effect.
Topics: Adolescent; Adult; Child; Chronic Disease; Drug Antagonism; Epilepsy; Humans; Phenobarbital; Phenoth | 1971 |
Diphenylhydantoin (Dilatin) and phenobarbital blood levels in epileptic children.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Chromatography, Gas; Electroencephalogr | 1971 |
[Treatment of epilepsy in the light of the determination of the anticonvulsant blood level].
Topics: Administration, Oral; Age Factors; Anticonvulsants; Drug Synergism; Epilepsy; Humans; Phenobarbital; | 1971 |
[Effect of 5,5-diphenylhydantoin and pneumoencephalography on urinary excretion of 5-hydroxyindoloacetic acid, a serotonin metabolite, and serum ceruloplasmin activity in epileptics].
Topics: Administration, Oral; Adolescent; Adult; Ceruloplasmin; Epilepsy; Female; Humans; Hydroxyindoleaceti | 1971 |
[Treatment of epilepsy with a combination of anticonvulsants in a group refractory to previously used drugs].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Barbiturates; Child; Drug Synergism; Drug Tolerance; Epile | 1971 |
The rapid quantitative determination of diphenyl hydantoin in plasma, serum, and whole blood of patients with epilepsy.
Topics: Chloroform; Epilepsy; Humans; Ketones; Methods; Phenytoin; Solubility; Spectrophotometry | 1971 |
Variations of serum diphenylhydantoin concentrations in epileptic out-patients.
Topics: Adolescent; Adult; Aged; Blood Proteins; Body Weight; Drug Synergism; Epilepsy; Female; Humans; Male | 1971 |
[Clinical and pharmacodynamic correlations of phenobarbital (PB) and diphenylhydantoin (DPH) in the treatment of infantile epilepsy].
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Infant; Phenobarbital; Phenytoin | 1971 |
Metabolite(s) of diphenylhydantoin in human plasma inhibit(s) the pentose phosphate pathway of leukocytes.
Topics: Administration, Oral; Adolescent; Adult; Aged; Blood Glucose; Body Weight; Child, Preschool; Epileps | 1971 |
Bone density in patients receiving long-term anticonvulsant therapy.
Topics: Absorptiometry, Photon; Adult; Alkaline Phosphatase; Anticonvulsants; Calcium; Carbamazepine; Epilep | 1971 |
[3 cases of malignant lymphoma or pseudolymphoma in epileptics treated with diphenylhydantoin].
Topics: Adult; Epilepsy; Female; Hodgkin Disease; Humans; Lymphoma; Male; Phenytoin | 1971 |
Folic acid concentrations in cerebrospinal fluid in relation to anticonvulsant drugs and cerebral atrophy.
Topics: Adult; Anticonvulsants; Atrophy; Brain Diseases; Epilepsy; Female; Folic Acid; Humans; Male; Mental | 1971 |
[Anticonvulsants. 4. Determination of phenytoin in plasma. Clinical studies].
Topics: Adult; Chromatography, Gas; Epilepsy; Female; Humans; Male; Phenytoin | 1971 |
Folate metabolism in epileptic and psychiatric patients.
Topics: Adult; Antidepressive Agents; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Hum | 1971 |
[Considerations apropos of drug treatment of 1,217 epileptic patients. 3: Study in relation to the drugs used].
Topics: Barbiturates; Drug Evaluation; Drug Synergism; Epilepsy; Humans; Phenytoin; Primidone | 1971 |
Drug interactions: effect of methylphenidate on the disposition of diphenylhydantoin in man.
Topics: Adult; Drug Interactions; Epilepsy; Female; Half-Life; Humans; Male; Methylphenidate; Phenytoin | 1971 |
[Onset of systemic lupus erythematosus during long term administration of diphenyl-hydantoin].
Topics: Adult; Biopsy; Epilepsy; Humans; Kidney; Lupus Erythematosus, Systemic; Male; Phenytoin | 1971 |
Musicogenic epilepsy. A case report.
Topics: Adult; Chlordiazepoxide; Electroencephalography; Emotions; Epilepsy; Epilepsy, Temporal Lobe; Hearin | 1965 |
A case report of evaluation and management of hyperplastic gingiva in epileptics caused by sodium dilantin therapy.
Topics: Dentistry; Epilepsy; Gingival Hyperplasia; Phenytoin | 1966 |
Recurrent ulcerative stomatitis and dilantin gingival fibromatosis.
Topics: Dentistry; Epilepsy; Fibromatosis, Gingival; Gingivitis, Necrotizing Ulcerative; Phenytoin | 1966 |
[Gingival hyperplasia caused by Diphedan].
Topics: Adolescent; Adult; Child; Epilepsy; Female; Gingival Hyperplasia; Humans; Male; Phenytoin | 1967 |
Management of gingival hyperplasia in patients receiving Dilantin therapy.
Topics: Dentistry; Epilepsy; Gingival Hyperplasia; Phenytoin | 1967 |
[On the pathomechanism of hydantoin-induced gingival hyperplasia].
Topics: Adolescent; Anticonvulsants; Child; Child, Institutionalized; Epilepsy; Female; Gingival Hyperplasia | 1968 |
[Clinical statistical contribution on gingival hyperplasia caused by anticonvulsants].
Topics: Adolescent; Adult; Barbiturates; Child; Epilepsy; Female; Gingival Hyperplasia; Histocytochemistry; | 1968 |
Comparative neuronal mechanisms.
Topics: Action Potentials; Animals; Annelida; Anura; Axons; Cell Membrane; Electric Stimulation; Epilepsy; G | 1969 |
[Modified technic for the treatment of gingival hyperplasia in epileptic patients].
Topics: Epilepsy; Gingival Hyperplasia; Phenytoin; Subgingival Curettage | 1969 |
[Dentistry for epileptics].
Topics: Dentistry; Epilepsy; Gingival Hyperplasia; Phenytoin | 1970 |
A clinical study of serum primidone levels.
Topics: Administration, Oral; Adolescent; Adult; Biotransformation; Child; Child, Preschool; Chromatography, | 1970 |
Interaction between phenobarbital and diphenylhydantoin in animals and in epileptic patients.
Topics: Adolescent; Adult; Animals; Brain; Brain Chemistry; Child; Child, Preschool; Chromatography, Gas; Ep | 1971 |
Epileptic nystagmus.
Topics: Adult; Chlordiazepoxide; Electroencephalography; Epilepsy; Female; Humans; Neurologic Examination; N | 1971 |
[Etiology of hydantoin gingiva hyperplasia and of the recidives].
Topics: Epilepsy; Female; Gingival Hyperplasia; Gingivectomy; Humans; Male; Phenytoin | 1971 |
Anticonvulsant drugs and folic acid in young mentally retarded epileptic patients. A study of serum folate, fit frequency and I.Q.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Ethosuximide; Female; Folic Acid; Human | 1971 |
Self-induced television epilepsy.
Topics: Adolescent; Electroencephalography; Epilepsy; Ethosuximide; Female; Humans; Myoclonus; Phenytoin; Te | 1971 |
Focal spike discharges in children, a longitudinal study.
Topics: Adolescent; Aging; Central Nervous System Diseases; Cerebral Palsy; Cerebral Ventriculography; Child | 1966 |
Osteomalacia with long-term anticonvulsant therapy in epilepsy.
Topics: Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Biopsy; Calcium; Enzyme Induction; Epileps | 1970 |
Plasma protein binding of diphenylhydantoin in man.
Topics: Adult; Aspirin; Bilirubin; Blood Proteins; Carbon Isotopes; Epilepsy; Female; Humans; Hydrogen-Ion C | 1971 |
Delayed phenytoin idiosyncrasy.
Topics: Ataxia; Epilepsy; Humans; Nystagmus, Pathologic; Phenytoin | 1969 |
Studies on the glucaric acid pathway in the metabolism of D-glucuronic acid in mammals. V. Stimulatory effect of diphenylhydantoin and phenobarbital on the D-glucaric acid synthesis in man.
Topics: Adipates; Epilepsy; Hexoses; Humans; Phenobarbital; Phenytoin; Stimulation, Chemical | 1969 |
Central effects of diphenylhydantoin (dilantin) in epileptic oligophrenics during phenobarbital-primidone withdrawal, sodium bicarbonate, and ammonium chloride administration.
Topics: Adolescent; Adult; Ammonium Chloride; Bicarbonates; Epilepsy; Female; Humans; Hydrogen-Ion Concentra | 1969 |
[Determination of diphenylhydantoin (DFH) in plasma in patients with epilepsy].
Topics: Drug Synergism; Epilepsy; Humans; Methods; Phenytoin | 1969 |
Lack of effect of diphenylhydantoin ingestion on vesical transitional epithelium in the rat.
Topics: Animals; Carcinogens; Carcinoma, Papillary; Epilepsy; Epithelium; Female; Humans; Male; Middle Aged; | 1969 |
Central effect of diphenylhydantoin (Dilantin) in epileptic oligophrenics during phenobarbital-primidone withdrawal, sodium bicarbonate, and ammonium chloride administration.
Topics: Adolescent; Adult; Ammonium Chloride; Bicarbonates; Epilepsy; Female; Humans; Hydrogen-Ion Concentra | 1969 |
Supervision of epileptic patients taking phenytoin.
Topics: Adult; Epilepsy; Female; Hospitalization; Humans; Male; Middle Aged; Outpatient Clinics, Hospital; P | 1970 |
Diphenylhydantoin intoxication. A complication of isoniazid therapy.
Topics: Adolescent; Adult; Animals; Biotransformation; Cats; Epilepsy; Female; Humans; Isoniazid; Male; Midd | 1970 |
Treatment of status epilepticus in dogs with diazepam sodium.
Topics: Animals; Barbiturates; Diazepam; Dog Diseases; Dogs; Epilepsy; Female; Injections, Intravenous; Male | 1970 |
Epileptics on phenytoin.
Topics: Epilepsy; Humans; Myocardial Infarction; Phenytoin | 1970 |
Pseudolymphoma induced by diphenylhydantoin.
Topics: Child; Epilepsy; Humans; Lymphoma; Male; Phenytoin; Skull Fractures | 1970 |
Classical hysterical seizures facilitated by anticonvulsant toxicity.
Topics: Achondroplasia; Adolescent; Adult; Electroencephalography; Epilepsy; Female; Humans; Hysteria; Male; | 1970 |
[Decentralized treatment and control of patients with epilepsy. 3-year material].
Topics: Adolescent; Adult; Age Factors; Ambulatory Care; Child; Child, Preschool; Electroencephalography; Ep | 1970 |
Phenytoin tolerance tests.
Topics: Administration, Oral; Adult; Arrhythmias, Cardiac; Chromatography, Thin Layer; Drug Tolerance; Epile | 1970 |
Folate and vitamin B12 in epilepsy.
Topics: Animals; Brain Chemistry; Cats; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenytoin; Rats | 1970 |
Calvarial thickening after Dilantin medication.
Topics: Adolescent; Adult; Age Factors; Epilepsy; Female; Humans; Male; Phenytoin; Radiography; Skull | 1970 |
Diphenylhydantoin intoxication attendant to slow inactivation of isoniazid.
Topics: Animals; Ataxia; Cats; Drug Tolerance; Epilepsy; Genetics, Medical; Humans; Isoniazid; Nystagmus, Pa | 1970 |
Passage of diphenylhydantoin across the placenta.
Topics: Adult; Epilepsy; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Phenytoin; Placenta | 1970 |
[Case of tonic seizure].
Topics: Adult; Arm; Benzazepines; Diphenhydramine; Electroencephalography; Epilepsy; Humans; Injections, Int | 1970 |
Disturbance of calcium metabolism by anticonvulsant drugs.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Calcium Metabolism Disorders; Enzyme | 1970 |
[Phenytoin intoxication--an insidous complication in the treatment of epilepsy].
Topics: Adult; Body Weight; Cerebellar Diseases; Child; Epilepsy; Female; Humans; Male; Movement Disorders; | 1970 |
The clinical significance of microsomal enzyme induction in the therapy of epileptic patients.
Topics: Adult; Chromatography; Enzyme Induction; Epilepsy; Female; Humans; Male; Microsomes, Liver; Phenobar | 1970 |
Micro-determination of serum phenobarbitone and diphenylhydantoin by gas-liquid chromatography.
Topics: Adult; Anticonvulsants; Chromatography, Gas; Epilepsy; Humans; Indicators and Reagents; Methods; Mic | 1970 |
Outbreak of anticonvulsant intoxication in an Australian city.
Topics: Australia; Calcium; Disease Outbreaks; Drug Compounding; Epilepsy; Humans; Lactose; Pharmaceutical V | 1970 |
Diphenylhydantoin fatal hepatic necrosis (a review of literature and report of a case treated with exchange transfusion).
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Exchange Tran | 1970 |
Elevated serum alkaline phosphatase levels in epilepsy during diphenylhydantoin therapy.
Topics: Adolescent; Adult; Alkaline Phosphatase; Epilepsy; Humans; Middle Aged; Phenytoin | 1970 |
'Idiopathic epilepsy'.
Topics: Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenytoin; Primidone; Prognosi | 1970 |
Pseudolymphoma induced by diphenylhydantoin.
Topics: Epilepsy; Humans; Lymphoma; Phenytoin | 1970 |
The value of phenytoin plasma levels in the treatment of epilepsy.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Middle Aged; Pheny | 1970 |
The value of blood phenytoin estimations in management of epilepsy.
Topics: Child; Child, Preschool; Epilepsy; Humans; Phenytoin | 1970 |
New developments in anticonvulsant therapy.
Topics: Anticonvulsants; Epilepsy; Humans; Phenobarbital; Phenytoin | 1970 |
Potentiation of the antiepileptic action of diphenylhydantoin by chlorothiazide congeners.
Topics: Animals; Chlorothiazide; Drug Synergism; Epilepsy; Female; Male; Phenytoin; Rats; Seizures | 1970 |
Anticonvulsants and hemorrhagic diseases of the newborn infant.
Topics: Epilepsy; Female; Humans; Infant, Newborn; Phenytoin; Pregnancy; Pregnancy Complications; Vitamin K | 1970 |
The distribution of plasma phenytoin levels in epileptic patients.
Topics: Adult; Drug Tolerance; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Primidone | 1970 |
Ammonium chloride as an adjuvant to diphenyl-hydantoin therapy, and bulk ions in the CSF and serum in forty mentally subnormal epileptics.
Topics: Ammonium Chloride; Bicarbonates; Calcium; Carbon Dioxide; Chlorides; Epilepsy; Humans; Intellectual | 1970 |
[Therapy of epilepsy in mentally retarded children. Neuropsychiatric disorders caused by diphenylhydantoin].
Topics: Adolescent; Affective Symptoms; Ataxia; Child; Epilepsy; Humans; Intellectual Disability; Male; Musc | 1970 |
Investigation of an outbreak of anticonvulsant intoxication.
Topics: Calcium; Epilepsy; Humans; Lactose; Pharmaceutical Vehicles; Phenytoin; Sulfates | 1970 |
Aspects of diphenylhydantoin metabolism.
Topics: Anticonvulsants; Blood Proteins; Chemical Phenomena; Chemistry; Drug Antagonism; Drug Synergism; Dru | 1970 |
Effects of diphenylhydantoin, pH and total carbon dioxide in the cerebrospinal fluid during sodium bicarbonate and ammonium chloride intake in forty mentally sub-normal epileptics.
Topics: Acid-Base Equilibrium; Adolescent; Adult; Ammonium Chloride; Bicarbonates; Calcium; Carbon Dioxide; | 1970 |
Ammonium chloride as an adjuvant to diphenylhydantoin therapy, and pH, base bicarbonate and sodium in the serum of forty mentally subnormal epileptics.
Topics: Acid-Base Equilibrium; Ammonium Chloride; Bicarbonates; Chlorides; Epilepsy; Humans; Hydrogen-Ion Co | 1970 |
P henobarbital-Dilantin treatment of the intrauterine patient.
Topics: Enzyme Induction; Epilepsy; Erythroblastosis, Fetal; Female; Fetal Diseases; Humans; Infant, Newborn | 1970 |
[Status epilepticus].
Topics: Diazepam; Electroencephalography; Epilepsy; Humans; Phenytoin | 1970 |
Elevated serum alkaline phosphatase levels in the epileptic patients treated with diphenylhydantoin.
Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Epilepsy | 1970 |
Effect of intraluminal pH on the absorption of pteroylmonoglutamic acid.
Topics: Bicarbonates; Epilepsy; Female; Folic Acid; Humans; Hydrogen-Ion Concentration; Intestinal Absorptio | 1971 |
Severe bradykinesia as a manifestation of toxicity to antiepileptic medications.
Topics: Acetazolamide; Anticonvulsants; Child; Epilepsy; Ethosuximide; Humans; Male; Mental Processes; Movem | 1971 |
Therapeutic dilantin levels.
Topics: Epilepsy; Humans; Phenytoin | 1971 |
Maternal folate deficiency and pregnancy wastage. IV. Effects of folic acid supplements, anticonvulsants, and oral contraceptives.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Anemia, Macrocytic; Anemia, Sickle Cell; Anemia, | 1971 |
Value of blood phenytoin estimation in management of childhood epilepsy.
Topics: Child; Child, Preschool; Epilepsy; Humans; Infant; Phenytoin | 1971 |
[Different adverse effects of phenytoin].
Topics: Epilepsy; Hematologic Diseases; Humans; Phenytoin | 1971 |
[Congenital abnormalities, cleft lip and cleft palate in particular, in children of epileptic mothers].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Cleft Lip; Cleft Palate; Epilepsy; Fema | 1971 |
Gas chromatographic assay of underivatized 5,5-diphenylhydantoin (dilantin) in plasma extracts.
Topics: Carbamazepine; Chloroform; Chromatography, Gas; Coma; Epilepsy; Humans; Hydrogen-Ion Concentration; | 1971 |
Jejunal pH and folic acid.
Topics: Barbiturates; Epilepsy; Folic Acid; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Jejun | 1971 |
Diphenylhydantoin: evidence for a central action.
Topics: Action Potentials; Animals; Cats; Cerebral Cortex; Epilepsy; Penicillins; Phenytoin; Purkinje Cells | 1971 |
The diagnostic and therapeutic use of diphenylhydantoin in the subictal state and non-epileptic dysphoria.
Topics: Adjustment Disorders; Antisocial Personality Disorder; Anxiety Disorders; Depression; Emotions; Epil | 1967 |
ACNP--session on diphenylhydantoin: introductory remarks.
Topics: Epilepsy; Humans; Mental Disorders; Phenytoin | 1967 |
The usefulness of diphenylhydantoin in treatment of non-epileptic emotional disorders.
Topics: Age Factors; Cell Membrane; Depression; Electroencephalography; Emotions; Epilepsy; Fear; Female; He | 1967 |
[The anti-epileptic and psychotropic properties of carbamazepine (Tegretol)].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Dibenzazepines; Epilepsy; Female; Humans; Male; M | 1967 |
[Present status of the treatment of epilepsy].
Topics: Anticonvulsants; Epilepsy; Phenytoin; Sodium | 1967 |
Epileptic seizures in non-embolic cerebral infarction.
Topics: Cerebrovascular Disorders; Epilepsy; Follow-Up Studies; Humans; Phenobarbital; Phenytoin | 1967 |
Serum folate deficiency in children receiving anticonvulsant therapy.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Erythrocyte Coun | 1968 |
[On the changes of conduction velocity of peripheral motor nerve fibers by dephenylhydantoin].
Topics: Adolescent; Adult; Electrophysiology; Epilepsy; Female; Humans; Male; Middle Aged; Motor Activity; M | 1968 |
Low specific gravity syndrome.
Topics: Adult; Anticonvulsants; Calcium; Chlorides; Chronic Disease; Creatinine; Epilepsy; Female; Humans; I | 1968 |
[Clinical side effects of phenytoin therapy].
Topics: Adult; Epilepsy; Humans; Middle Aged; Phenytoin | 1968 |
"Dilantin" overdosage.
Topics: Epilepsy; Humans; Phenytoin | 1968 |
The neurologic hazards of diphenylhydantoin in childhood.
Topics: Adolescent; Ataxia; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Neurologic Mani | 1968 |
"Dilantin" overdose.
Topics: Epilepsy; Humans; Phenytoin | 1968 |
Folic acid deficiency from anticonvulsant therapy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Folic Acid Defic | 1968 |
[Course of epilepsy and significance of determination of phenytoin in the serum].
Topics: Child; Epilepsy; Humans; Phenobarbital; Phenytoin; Prognosis | 1968 |
Comparison of blood levels with oral and intramuscular diphenylhydantoin.
Topics: Adult; Aged; Electroencephalography; Epilepsy; Female; Humans; Injections, Intramuscular; Male; Midd | 1968 |
Management of epilepsy with diphenylhydantoin sodium. Dosage regulation for problem patients.
Topics: Adult; Antitubercular Agents; Ataxia; Drug Tolerance; Epilepsy; Hospitalization; Humans; Nystagmus, | 1968 |
Diphenylhydantoin in emotional disorders.
Topics: Arrhythmias, Cardiac; Epilepsy; Humans; Mental Disorders; Migraine Disorders; Phenytoin; Tic Disorde | 1968 |
Plasma hydroxyproline in epilepsy.
Topics: Adolescent; Adult; Collagen; Connective Tissue; Epilepsy; Female; Humans; Hydroxyproline; Male; Meth | 1968 |
Effect of phenytoin on the tryptophan load test.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Diagnosis, Differential; Epilepsy; Female; Humans; | 1968 |
[On the problem of the treatment of cerebral epilepsy during pregnancy, labor and puerperium].
Topics: Anticonvulsants; Delivery, Obstetric; Epilepsy; Female; Humans; Obstetric Labor Complications; Pheno | 1968 |
Dilantin dementia.
Topics: Epilepsy; Humans; Mental Processes; Phenytoin | 1968 |
[The necessary dosis of antiepileptic drugs in epileptic children during their growth period].
Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Body Weight; Child; Child Development; Child, Pres | 1968 |
Mental effects of anticonvulsants, and folic acid metabolism.
Topics: Age Factors; Anemia, Macrocytic; Anticonvulsants; Brain; Epilepsy; Female; Folic Acid; Folic Acid De | 1968 |
A quantitative study of the acute effects of diphenylhydantoin on the electroencephalogram of epileptic patients. Theoretical considerations for its use in the treatment of status epilepticus.
Topics: Adolescent; Adult; Central Nervous System; Computers; Electroencephalography; Epilepsy; Female; Huma | 1968 |
[Changing of the photosensible threshold in the electroencephalogram by drugs acting in the central nervous system].
Topics: Adolescent; Adult; Aged; Barbiturates; Central Nervous System; Child; Diazepam; Electroencephalograp | 1968 |
The multiple system effects of diphenylhydantoin (Dilantin).
Topics: Epilepsy; Female; Humans; Middle Aged; Phenytoin | 1969 |
Diphenylhydantoin gingival hyperplasia.
Topics: Adolescent; Child; Epilepsy; Female; Gingival Hyperplasia; Gingivectomy; Humans; Male; Middle Aged; | 1969 |
[Effect of 5-5-sodium diphenylhydantoin on the gastric mucosa].
Topics: Adult; Aged; Epilepsy; Female; Gastric Mucosa; Gastritis; Humans; Male; Middle Aged; Phenytoin | 1969 |
Thin-layer chromatography of anticonvulsant drugs.
Topics: Anticonvulsants; Chromatography, Thin Layer; Epilepsy; Humans; Hydantoins; Methods; Phenobarbital; P | 1969 |
Ten years EEG studies in epileptic children (two cases).
Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Emotions; Epilepsy; Humans; Mephobarbit | 1969 |
[Control of diphenylhydantoin dosage in epileptic seizures by determination of the serum levels].
Topics: Adult; Epilepsy; Female; Humans; Male; Methods; Phenytoin | 1969 |
[Permanent cerebellar damage through temporary overdase of hydantoin].
Topics: Adult; Cerebellar Diseases; Chronic Disease; Electroencephalography; Epilepsy; Female; Humans; Pheny | 1969 |
Use of diphenylhydantoin in epilepsy treatment.
Topics: Ataxia; Chemical and Drug Induced Liver Injury; Epilepsy; Humans; Necrosis; Nervous System Diseases; | 1969 |
Increased metabolism of metyrapone in rats pretreated with diphenylhydantoin or phenobarbital.
Topics: Adrenal Glands; Animals; Biotransformation; Chromatography, Thin Layer; Enzyme Induction; Epilepsy; | 1969 |
[Phenytoin dosage and preparation forms].
Topics: Drug Compounding; Drug Synergism; Epilepsy; Humans; Phenytoin; Tablets | 1969 |
Folic acid and anticonvulsive drugs.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Erythrocyte Count; Female; FIGLU Test; Folic Acid; Fol | 1969 |
Clinical therapeutic conditioning in reading epilepsy.
Topics: Adolescent; Behavior Therapy; Electroencephalography; Epilepsy; Galvanic Skin Response; Humans; Male | 1969 |
Nil nocere. Unusual hyperkinetic syndromes following diphenylhydantoin administration.
Topics: Adult; Epilepsy; Female; Humans; Hyperkinesis; Injections, Intravenous; Middle Aged; Phenytoin | 1969 |
[Study on long-active effect of antiepileptic agents].
Topics: Adolescent; Adult; Chronic Disease; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Seizures | 1969 |
[Serum phenytoin levels following intramuscular injection in relation to treatment of status epilepticus].
Topics: Adolescent; Adult; Blood; Epilepsy; Humans; Injections, Intramuscular; Middle Aged; Phenytoin | 1965 |
EFG activation of patients receiving phenothiazines and chlordiazepoxide.
Topics: Adult; Anxiety; Cerebral Cortex; Chloralose; Chlordiazepoxide; Chlorpromazine; Depression; Electroen | 1965 |
[Myasthenic syndrome as a rare complication of hydantoin treatment].
Topics: Adult; Blood Sedimentation; Curare; Edrophonium; Electrocardiography; Electromyography; Epilepsy; Fe | 1965 |
Studies of diphenylhydantoin metabolism.
Topics: Blood; Epilepsy; Intestinal Absorption; Phenytoin | 1965 |
[Association of pyrithioxin and diphenylhydantoin in the treatment of organic epileptic syndromes].
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Infant; Middle Aged; | 1965 |
Significance of seizures in patients receiving psychotropic drugs.
Topics: Adult; Drug Hypersensitivity; Epilepsy; Humans; Male; Meprobamate; Phenytoin; Schizophrenia; Seizure | 1965 |
Diphenylhydantoin toxicity; lymphadenopathy and low platelet count.
Topics: Adolescent; Blood Coagulation Disorders; Blood Platelet Disorders; Epilepsy; Humans; Lymphadenitis; | 1966 |
Some causes of ineffectiveness of diphenylhydantoin.
Topics: Aged; Blood; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin | 1966 |
Fever. An unusual manifestation of epilepsy.
Topics: Child; Epilepsy; Fever; Humans; Male; Phenytoin | 1966 |
Intramuscular administration of phenytoin.
Topics: Epilepsy; Humans; Injections, Intramuscular; Phenytoin | 1966 |
Depression of prahydroxylation of diphenylhydantoin by antituberculosis chemotherapy.
Topics: Adolescent; Adult; Aged; Aminosalicylic Acids; Anticonvulsants; Ataxia; Cycloserine; Drug Incompatib | 1966 |
Drug-induced systemic lupus erythematosus. Primidone as a possible cause.
Topics: Electroencephalography; Epilepsy; Female; Humans; Hydralazine; Hydroxychloroquine; Lupus Erythematos | 1966 |
Enuresis and its relationship to electroencephalographic disturbances.
Topics: Adolescent; Adult; Brain Diseases; Child; Child, Preschool; Electroencephalography; Enuresis; Epilep | 1966 |