phenytoin has been researched along with Atrophy in 50 studies
Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic intoxication of phenytoin (PHT) is a well known cause of cerebellar atrophy or irreversible cerebellar ataxia." | 8.78 | [Cerebellar atrophy and persistent cerebellar ataxia after acute intoxication of phenytoin]. ( Ejima, A; Imamura, T; Sahara, M; Saito, H; Tsuburaya, K, 1992) |
| "Phenytoin is known to be able to induce cerebellar atrophy in patients with epilepsy." | 7.79 | The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy. ( Borgio, JG; De Paola, L; Scola, RH; Silvado, C; Twardowschy, CA; Werneck, LC, 2013) |
| "A 44-year-old man with treated neurosyphilis presented with subclinical status epilepticus (SE) refractory to intravenous high-dose lorazepam, phenytoin, and valproic acid over 4 days." | 7.72 | Ketamine for refractory status epilepticus: a case of possible ketamine-induced neurotoxicity. ( Lerner, AJ; Maddux, BN; Sagar, SM; Suarez, JI; Ubogu, EE; Werz, MA, 2003) |
| " The purpose of this study was to investigate the afferent fiber system to the cerebellum in patients with phenytoin (PHT)-induced cerebellar atrophy in comparison with cerebellar atrophy of other etiologies by using DT-MRI." | 7.72 | Diffusion tensor MRI and fiber tractography of cerebellar atrophy in phenytoin users. ( Chu, M; Heo, K; Kim, DI; Kim, DJ; Kim, SY; Lee, BI; Lee, SK; Mori, S, 2003) |
| "A 30-year-old man was given high doses of phenytoin together with 4 antituberculous drugs for a seizure associated with a probable brain tuberculoma." | 7.70 | [Residual cerebellar ataxia following acute phenytoin intoxication]. ( al Beladi, K; al Jumah, M; Amene, P; Awada, A, 1999) |
| "The chronic treatment with phenytoin or the acute intoxication by this drug may cause permanent cerebellar injury with atrophy of cerebellum vermis and hemispheres, which can be detected by neuroimaging studies." | 7.70 | [Dose-dependent relationship of chronic use of phenytoin and cerebellar atrophy in patients with epilepsy]. ( Cendes, F; Dantas, CD; Del Negro, A; Montenegro, MA; Zanardi, V, 2000) |
| "There is some evidence that long-term phenytoin (PHT) use may occasionally give rise to irreversible cerebellar atrophy, but it is unclear whether such changes can occur after acute PHT intoxication." | 7.69 | Cerebellar atrophy after acute phenytoin intoxication. ( Bharucha, NE; Kuruvilla, T, 1997) |
| "Thirty-six patients with partial epilepsy and long-term phenytoin exposure were selected from a consecutive sample of admissions to an epilepsy center." | 7.69 | Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy. ( Barr, WB; Lantos, G; Ney, GC; Schaul, N, 1994) |
| "Valproic acid induced coma is presented in an adult patient without a history of metabolic disease." | 7.68 | Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. ( Colombo, JP; Straver, JS; van der Vijver, JC; van Woerkom, TC; Verbiest, HB, 1992) |
| "A patient developed marked cerebellar atrophy after a single suicidal intoxication with 7 grams phenytoin." | 7.67 | Cerebellar atrophy following acute intoxication with phenytoin. ( Elger, CE; Galanski, M; Ludolph, AC; Masur, H, 1989) |
| " Using accepted CT criteria for the diagnosis of cerebellar atrophy, the films were analyzed in a blind, unbiased fashion to evaluate possible relationship between cerebellar atrophy and phenytoin use or epilepsy itself." | 7.66 | Cerebellar atrophy in epilepsy and headache: lack of relationship to phenytoin. ( Ballenger, CE; Brooks, BS; El Gammal, T; Green, JB; King, DW; Lucke, JF, 1982) |
| "Phenytoin, given to a cat in proportions therapeutic for man (5 to 8 mg/kg), induced severe dermal atrophy with excessive fragility of the skin following daily oral administration for 3 weeks." | 7.66 | Reversible dermal atrophy in a cat treated with phenytoin. ( Barthold, SW; Kaplan, BJ; Schwartz, A, 1980) |
| "The relationship among the serum concentration of phenytoin, pneumoencephalographic measurements describing, in particular, cerebellar atrophy, and various other clinical variables was analyzed statistically in a series of 131 phenytoin-treated mentally retarded epileptics." | 7.65 | Cerebellar atrophy in phenytoin-treated mentally retarded epileptics. ( Helle, EP; Iivanainen, M; Viukari, M, 1977) |
| "Phenytoin has been considered a possible cause of cerebellar degeneration, especially after clinical intoxication." | 5.29 | [Cerebellar atrophy and phenytoin poisoning. An MR study]. ( Aichner, F; Bauer, G; Birbamer, G; Felber, S; Luef, G; Marosi, M, 1993) |
| "Chronic intoxication of phenytoin (PHT) is a well known cause of cerebellar atrophy or irreversible cerebellar ataxia." | 4.78 | [Cerebellar atrophy and persistent cerebellar ataxia after acute intoxication of phenytoin]. ( Ejima, A; Imamura, T; Sahara, M; Saito, H; Tsuburaya, K, 1992) |
| "Phenytoin is known to be able to induce cerebellar atrophy in patients with epilepsy." | 3.79 | The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy. ( Borgio, JG; De Paola, L; Scola, RH; Silvado, C; Twardowschy, CA; Werneck, LC, 2013) |
| "A 44-year-old man with treated neurosyphilis presented with subclinical status epilepticus (SE) refractory to intravenous high-dose lorazepam, phenytoin, and valproic acid over 4 days." | 3.72 | Ketamine for refractory status epilepticus: a case of possible ketamine-induced neurotoxicity. ( Lerner, AJ; Maddux, BN; Sagar, SM; Suarez, JI; Ubogu, EE; Werz, MA, 2003) |
| " The purpose of this study was to investigate the afferent fiber system to the cerebellum in patients with phenytoin (PHT)-induced cerebellar atrophy in comparison with cerebellar atrophy of other etiologies by using DT-MRI." | 3.72 | Diffusion tensor MRI and fiber tractography of cerebellar atrophy in phenytoin users. ( Chu, M; Heo, K; Kim, DI; Kim, DJ; Kim, SY; Lee, BI; Lee, SK; Mori, S, 2003) |
| "A 30-year-old man was given high doses of phenytoin together with 4 antituberculous drugs for a seizure associated with a probable brain tuberculoma." | 3.70 | [Residual cerebellar ataxia following acute phenytoin intoxication]. ( al Beladi, K; al Jumah, M; Amene, P; Awada, A, 1999) |
| "The chronic treatment with phenytoin or the acute intoxication by this drug may cause permanent cerebellar injury with atrophy of cerebellum vermis and hemispheres, which can be detected by neuroimaging studies." | 3.70 | [Dose-dependent relationship of chronic use of phenytoin and cerebellar atrophy in patients with epilepsy]. ( Cendes, F; Dantas, CD; Del Negro, A; Montenegro, MA; Zanardi, V, 2000) |
| " The stress-induced CA3 apical dendritic atrophy in subordinates was prevented by administering daily oral doses of the antiepileptic drug phenytoin (Dilantin, Sigma, St." | 3.69 | Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. ( Flügge, G; Fuchs, E; Magariños, AM; McEwen, BS, 1996) |
| "Thirty-six patients with partial epilepsy and long-term phenytoin exposure were selected from a consecutive sample of admissions to an epilepsy center." | 3.69 | Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy. ( Barr, WB; Lantos, G; Ney, GC; Schaul, N, 1994) |
| "There is some evidence that long-term phenytoin (PHT) use may occasionally give rise to irreversible cerebellar atrophy, but it is unclear whether such changes can occur after acute PHT intoxication." | 3.69 | Cerebellar atrophy after acute phenytoin intoxication. ( Bharucha, NE; Kuruvilla, T, 1997) |
| "Valproic acid induced coma is presented in an adult patient without a history of metabolic disease." | 3.68 | Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. ( Colombo, JP; Straver, JS; van der Vijver, JC; van Woerkom, TC; Verbiest, HB, 1992) |
| " Statistical analyses showed that group 2 had a longer history of epilepsy with a consequently longer duration of phenytoin (PHT) consumption." | 3.67 | Role of the cerebellum in complex human behavior. ( Attig, E; Botez, MI; Botez, T; Elie, R, 1989) |
| "A patient developed marked cerebellar atrophy after a single suicidal intoxication with 7 grams phenytoin." | 3.67 | Cerebellar atrophy following acute intoxication with phenytoin. ( Elger, CE; Galanski, M; Ludolph, AC; Masur, H, 1989) |
| " Using accepted CT criteria for the diagnosis of cerebellar atrophy, the films were analyzed in a blind, unbiased fashion to evaluate possible relationship between cerebellar atrophy and phenytoin use or epilepsy itself." | 3.66 | Cerebellar atrophy in epilepsy and headache: lack of relationship to phenytoin. ( Ballenger, CE; Brooks, BS; El Gammal, T; Green, JB; King, DW; Lucke, JF, 1982) |
| "The folic acid absorption test (FAAT) has carried out in 18 normal control subjects; 8 patients with proven atrophy of the jejunal mucosa; 7 patients with gastric ulcus; 17 patients with reactive hypoglycemia; 13 patients with diabetes mellitus, and, finally, 9 epileptic patients treated with diphenylhydantoin (DPH)." | 3.66 | Folic acid absorption test in various clinical conditions. ( Bachevalier, J; Botez, MI, 1981) |
| "Phenytoin, given to a cat in proportions therapeutic for man (5 to 8 mg/kg), induced severe dermal atrophy with excessive fragility of the skin following daily oral administration for 3 weeks." | 3.66 | Reversible dermal atrophy in a cat treated with phenytoin. ( Barthold, SW; Kaplan, BJ; Schwartz, A, 1980) |
| "The relationship among the serum concentration of phenytoin, pneumoencephalographic measurements describing, in particular, cerebellar atrophy, and various other clinical variables was analyzed statistically in a series of 131 phenytoin-treated mentally retarded epileptics." | 3.65 | Cerebellar atrophy in phenytoin-treated mentally retarded epileptics. ( Helle, EP; Iivanainen, M; Viukari, M, 1977) |
| "Most patients with cerebellar dysfunction have phenytoin concentrations above the reference range." | 2.82 | Phenytoin and damage to the cerebellum - a systematic review of published cases. ( Bradberry, SM; Day, R; Ferner, R, 2022) |
| "Limbic encephalitis is a rare central nervous system (CNS) manifestation of relapsing polychondritis (RP)." | 1.35 | Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis. ( Kashihara, K; Kawada, S; Takahashi, Y, 2009) |
| "Carbamazepine was given to 15 patients, phenytoin to 12, and barbiturate to 7, respectively; 42 patients also received corticosteroids." | 1.30 | Late radiation toxicity after whole brain radiotherapy: the influence of antiepileptic drugs. ( Leicht, A; Motaref, B; Nestle, U; Nieder, C; Niewald, M; Schnabel, K, 1999) |
| "Phenytoin has been considered a possible cause of cerebellar degeneration, especially after clinical intoxication." | 1.29 | [Cerebellar atrophy and phenytoin poisoning. An MR study]. ( Aichner, F; Bauer, G; Birbamer, G; Felber, S; Luef, G; Marosi, M, 1993) |
| "Phenytoin has been implicated as a causative agent in peripheral neuropathy, although structural changes in nerve have not been characterized." | 1.27 | Phenytoin neuropathy: structural changes in the sural nerve. ( Griggs, RC; Mendell, JR; Ramirez, JA; Warmolts, JR, 1986) |
| "Reversible cerebellar dysfunction is a common manifestation of acute phenytoin toxicity." | 1.26 | [Diphenylhydantoin, epilepsy, cerebellar atrophy--histological and electron microscope examinations (author's transl)]. ( Breiden-Arends, C; Gullotta, F, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (40.00) | 18.7374 |
| 1990's | 18 (36.00) | 18.2507 |
| 2000's | 8 (16.00) | 29.6817 |
| 2010's | 3 (6.00) | 24.3611 |
| 2020's | 1 (2.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferner, R | 1 |
| Day, R | 1 |
| Bradberry, SM | 1 |
| Xu, C | 1 |
| Wang, Y | 2 |
| Zhang, S | 1 |
| Nao, J | 1 |
| Liu, Y | 1 |
| Ding, F | 1 |
| Zhong, K | 1 |
| Chen, L | 1 |
| Ying, X | 1 |
| Wang, S | 1 |
| Zhou, Y | 1 |
| Duan, S | 1 |
| Chen, Z | 1 |
| Brown, ES | 1 |
| Lu, H | 1 |
| Denniston, D | 1 |
| Uh, J | 1 |
| Thomas, BP | 1 |
| Carmody, TJ | 1 |
| Auchus, RJ | 1 |
| Diaz-Arrastia, R | 1 |
| Tamminga, C | 1 |
| Kashihara, K | 1 |
| Kawada, S | 1 |
| Takahashi, Y | 1 |
| Twardowschy, CA | 1 |
| Werneck, LC | 1 |
| Scola, RH | 1 |
| Borgio, JG | 1 |
| De Paola, L | 1 |
| Silvado, C | 1 |
| Ubogu, EE | 1 |
| Sagar, SM | 1 |
| Lerner, AJ | 1 |
| Maddux, BN | 1 |
| Suarez, JI | 1 |
| Werz, MA | 1 |
| OKUDA, O | 1 |
| SHINOHARA, S | 1 |
| Lee, SK | 1 |
| Mori, S | 1 |
| Kim, DJ | 1 |
| Kim, SY | 2 |
| Chu, M | 1 |
| Heo, K | 1 |
| Lee, BI | 1 |
| Kim, DI | 1 |
| Chow, KM | 1 |
| Szeto, CC | 1 |
| Feuerstein, T | 1 |
| von Reutern, GM | 1 |
| Cramer, H | 1 |
| Lindvall, O | 1 |
| Nilsson, B | 1 |
| Procházková, V | 1 |
| Urban, P | 1 |
| Roman, EJ | 1 |
| Buchanan, N | 1 |
| Lambert, JB | 1 |
| Barrah, N | 1 |
| Baier, WK | 1 |
| Beck, U | 1 |
| Doose, H | 1 |
| Klinge, H | 1 |
| Hirsch, W | 1 |
| Koller, WC | 1 |
| Glatt, SL | 1 |
| Perlik, S | 1 |
| Huckman, MS | 1 |
| Fox, JH | 1 |
| Claus, D | 1 |
| Aschoff, JC | 1 |
| Ballenger, CE | 1 |
| Lucke, JF | 1 |
| King, DW | 1 |
| El Gammal, T | 1 |
| Brooks, BS | 1 |
| Green, JB | 1 |
| Botez, MI | 2 |
| Bachevalier, J | 1 |
| Breiden-Arends, C | 1 |
| Gullotta, F | 1 |
| McLain, LW | 1 |
| Martin, JT | 1 |
| Allen, JH | 1 |
| Barthold, SW | 1 |
| Kaplan, BJ | 1 |
| Schwartz, A | 1 |
| Theodore, WH | 1 |
| Luef, G | 2 |
| Chemelli, A | 1 |
| Birbamer, G | 2 |
| Aichner, F | 2 |
| Bauer, G | 2 |
| Ney, GC | 1 |
| Lantos, G | 1 |
| Barr, WB | 1 |
| Schaul, N | 1 |
| Ringo, JL | 1 |
| Marosi, M | 1 |
| Felber, S | 1 |
| Blumberg, HP | 1 |
| Kanwal, GS | 1 |
| Relkin, N | 1 |
| Mattis, S | 1 |
| Viederman, M | 1 |
| Makari, GJ | 1 |
| Magariños, AM | 1 |
| McEwen, BS | 2 |
| Flügge, G | 1 |
| Fuchs, E | 1 |
| Kuruvilla, T | 1 |
| Bharucha, NE | 1 |
| Errea-Abad, JM | 1 |
| González-Igual, J | 1 |
| Eito-Cativiela, JL | 1 |
| Gastón-Añaños, J | 1 |
| Awada, A | 1 |
| Amene, P | 1 |
| al Jumah, M | 1 |
| al Beladi, K | 1 |
| Fujimoto, K | 1 |
| Nakano, I | 1 |
| Nieder, C | 1 |
| Leicht, A | 1 |
| Motaref, B | 1 |
| Nestle, U | 1 |
| Niewald, M | 1 |
| Schnabel, K | 1 |
| Hironishi, M | 1 |
| Del Negro, A | 1 |
| Dantas, CD | 1 |
| Zanardi, V | 1 |
| Montenegro, MA | 1 |
| Cendes, F | 1 |
| Alioğlu, Z | 1 |
| Sari, A | 1 |
| Velioğlu, SK | 1 |
| Ouml;zmenoğlu, M | 1 |
| Tan, EK | 1 |
| Chan, LL | 1 |
| Auchus, AP | 1 |
| Heim, M | 1 |
| Morgner, J | 1 |
| Iivanainen, M | 1 |
| Viukari, M | 1 |
| Helle, EP | 1 |
| Watanabe, Y | 1 |
| Gould, E | 1 |
| Cameron, HA | 1 |
| Daniels, DC | 1 |
| Verbiest, HB | 1 |
| Straver, JS | 1 |
| Colombo, JP | 1 |
| van der Vijver, JC | 1 |
| van Woerkom, TC | 1 |
| Imamura, T | 1 |
| Ejima, A | 1 |
| Sahara, M | 1 |
| Saito, H | 1 |
| Tsuburaya, K | 1 |
| Hirai, M | 1 |
| Ichikawa, M | 1 |
| Heikkinen, ER | 1 |
| Rönty, HS | 1 |
| Tolonen, U | 1 |
| Pyhtinen, J | 1 |
| Masur, H | 2 |
| Fahrendorf, G | 1 |
| Oberwittler, C | 1 |
| Reuther, G | 1 |
| Botez, T | 1 |
| Elie, R | 1 |
| Attig, E | 1 |
| Elger, CE | 1 |
| Ludolph, AC | 1 |
| Galanski, M | 1 |
| Ramirez, JA | 1 |
| Mendell, JR | 1 |
| Warmolts, JR | 1 |
| Griggs, RC | 1 |
| Bechinger, D | 1 |
| Klotz, R | 1 |
| Kornhuber, HH | 1 |
| Jensen, ON | 1 |
| Olesen, OV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study to Assess the Efficacy of Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy[NCT05019885] | Phase 2 | 6 participants (Anticipated) | Interventional | 2022-08-26 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for phenytoin and Atrophy
| Article | Year |
|---|---|
Phenytoin and damage to the cerebellum - a systematic review of published cases.
Topics: Adult; Ataxia; Atrophy; Cerebellar Ataxia; Cerebellar Diseases; Cerebellum; Humans; Phenytoin | 2022 |
[Acquired cortical cerebellar atrophy].
Topics: Alcoholism; Anticonvulsants; Antidepressive Agents; Antineoplastic Agents; Atrophy; Bromisovalum; Ce | 1999 |
[Cerebellar atrophy and persistent cerebellar ataxia after acute intoxication of phenytoin].
Topics: Adult; Atrophy; Cerebellar Ataxia; Cerebellum; Humans; Male; Phenytoin; Tomography, X-Ray Computed | 1992 |
1 trial available for phenytoin and Atrophy
| Article | Year |
|---|---|
A randomized, placebo-controlled proof-of-concept, crossover trial of phenytoin for hydrocortisone-induced declarative memory changes.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Atrophy; Cross-Over Studies; Double-Blind Method; Femal | 2013 |
46 other studies available for phenytoin and Atrophy
| Article | Year |
|---|---|
Subicular pyramidal neurons gate drug resistance in temporal lobe epilepsy.
Topics: Animals; Atrophy; Clozapine; Drug Resistant Epilepsy; Electric Stimulation; Epilepsy, Temporal Lobe; | 2019 |
Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis.
Topics: Amygdala; Anti-Inflammatory Agents; Anticonvulsants; Atrophy; Autoantibodies; Biomarkers; Brain; Car | 2009 |
The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy.
Topics: Adolescent; Adult; Aged; Alleles; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Atrophy; Cerebella | 2013 |
Ketamine for refractory status epilepticus: a case of possible ketamine-induced neurotoxicity.
Topics: Adult; Anticonvulsants; Atrophy; Brain; Electroencephalography; Excitatory Amino Acid Antagonists; H | 2003 |
[OBSERVATION ON TWO CASES OF EPILEPSIA CURSIVA].
Topics: Adolescent; Atrophy; Barbiturates; Cerebral Cortex; Chlordiazepoxide; Dichlorphenamide; Electroencep | 1964 |
Diffusion tensor MRI and fiber tractography of cerebellar atrophy in phenytoin users.
Topics: Adult; Afferent Pathways; Anisotropy; Anticonvulsants; Atrophy; Cerebellum; Diagnosis, Differential; | 2003 |
Cerebral atrophy and skull thickening due to chronic phenytoin therapy.
Topics: Adult; Anticonvulsants; Atrophy; Cerebellar Diseases; Diagnosis, Differential; Epilepsy; Female; Hum | 2007 |
[Phenytoin poisoning in a degradation disorder, report of a case with cerebellar atrophy].
Topics: Adult; Atrophy; Cerebellar Ataxia; Cerebellum; Cholestyramine Resin; Electroencephalography; Epileps | 1983 |
Cerebellar atrophy following phenytoin intoxication.
Topics: Adult; Atrophy; Cerebellar Ataxia; Cerebellum; Humans; Male; Phenytoin; Tomography, X-Ray Computed | 1984 |
[Hydantoin atrophy (degeneration) of the cerebellum].
Topics: Adolescent; Adult; Atrophy; Cerebellar Diseases; Female; Humans; Male; Phenytoin | 1984 |
Rationalisation of therapy in severe epilepsy.
Topics: Adult; Anticonvulsants; Arousal; Atrophy; Cerebellum; Drug Administration Schedule; Drug Therapy, Co | 1983 |
Cerebellar atrophy following diphenylhydantoin intoxication.
Topics: Adolescent; Atrophy; Cerebellum; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Ph | 1984 |
Cerebellar atrophy demonstrated by computed tomography.
Topics: Adult; Alcoholism; Atrophy; Carcinoma; Cerebellar Diseases; Cerebellar Neoplasms; Cerebral Ventricul | 1981 |
Evaluation of infratentorial atrophy by computed tomography.
Topics: Adolescent; Adult; Aged; Alcoholism; Atrophy; Cerebellopontine Angle; Cerebellum; Cerebral Ventricle | 1982 |
Cerebellar atrophy in epilepsy and headache: lack of relationship to phenytoin.
Topics: Adolescent; Adult; Atrophy; Cerebellum; Epilepsy; Female; Headache; Humans; Male; Phenytoin; Tomogra | 1982 |
Folic acid absorption test in various clinical conditions.
Topics: Adult; Aged; Atrophy; Diabetes Mellitus; Epilepsy; Folic Acid; Gastrointestinal Diseases; Humans; Hy | 1981 |
[Diphenylhydantoin, epilepsy, cerebellar atrophy--histological and electron microscope examinations (author's transl)].
Topics: Adult; Atrophy; Cerebellar Diseases; Cerebellum; Endoplasmic Reticulum; Epilepsy; Female; Humans; Ma | 1981 |
Cerebellar degeneration due to chronic phenytoin therapy.
Topics: Adult; Atrophy; Cerebellar Diseases; Female; Humans; Male; Middle Aged; Phenytoin; Seizures; Tomogra | 1980 |
Reversible dermal atrophy in a cat treated with phenytoin.
Topics: Administration, Oral; Animals; Atrophy; Cat Diseases; Cats; Collagen Diseases; Male; Phenytoin; Skin | 1980 |
Phenytoin and cerebellar atrophy.
Topics: Atrophy; Cerebellum; Humans; Phenytoin; Seizures | 1995 |
Phenytoin overdosage and cerebellar atrophy in epileptic patients: clinical and MRI findings.
Topics: Adult; Atrophy; Cerebellar Diseases; Cerebellum; Drug Overdose; Epilepsy; Female; Humans; Magnetic R | 1994 |
Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy.
Topics: Adult; Atrophy; Cerebellum; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin | 1994 |
The medial temporal lobe in encoding, retention, retrieval and interhemispheric transfer of visual memory in primates.
Topics: Animals; Atrophy; Brain Mapping; Corpus Callosum; Discrimination, Psychological; Electric Stimulatio | 1993 |
[Cerebellar atrophy and phenytoin poisoning. An MR study].
Topics: Adult; Anticonvulsants; Atrophy; Cerebellar Ataxia; Cerebellum; Dose-Response Relationship, Drug; Dr | 1993 |
Psychiatric complications in a patient with complex partial seizures.
Topics: Atrophy; Brain; Brain Diseases; Comorbidity; Epilepsy, Complex Partial; Humans; Magnetic Resonance I | 1996 |
Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews.
Topics: Animals; Atrophy; Body Weight; Dendrites; Hippocampus; Hydrocortisone; Male; Phenytoin; Pyramidal Ce | 1996 |
Cerebellar atrophy after acute phenytoin intoxication.
Topics: Acute Disease; Adult; Atrophy; Cerebellar Diseases; Cerebellum; Drug Overdose; Humans; Magnetic Reso | 1997 |
[Acute phenytoin poisoning due to its interaction with fluoropyramidine].
Topics: Acute Disease; Aged; Anticonvulsants; Atrophy; Brain; Drug Interactions; Humans; Magnetic Resonance | 1998 |
[Residual cerebellar ataxia following acute phenytoin intoxication].
Topics: Adult; Anticonvulsants; Atrophy; Brain; Brain Neoplasms; Cerebellar Ataxia; Cerebellum; Epilepsy; Hu | 1999 |
Late radiation toxicity after whole brain radiotherapy: the influence of antiepileptic drugs.
Topics: Actuarial Analysis; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anticonvulsants; Atrophy; | 1999 |
[Cerebellar atrophy associated with phenytoin intoxication].
Topics: Adult; Atrophy; Cerebellar Diseases; Humans; Male; Phenytoin; Poisoning | 2000 |
[Dose-dependent relationship of chronic use of phenytoin and cerebellar atrophy in patients with epilepsy].
Topics: Adult; Anticonvulsants; Atrophy; Cerebellum; Dose-Response Relationship, Drug; Epilepsy; Female; Hum | 2000 |
Cerebellar atrophy following acute phenytoin intoxication.
Topics: Acute Disease; Adult; Anticonvulsants; Atrophy; Cerebellum; Female; Humans; Phenytoin | 2000 |
Phenytoin cerebellopathy without epilepsy.
Topics: Anticonvulsants; Atrophy; Cerebellar Diseases; Female; Humans; Middle Aged; Motor Skills Disorders; | 2001 |
[Toxic "atrophie cerebelleuse". (problems associated with permanent cerebellar damage due to chronic diphenylhydantion intoxication)].
Topics: Adult; Atrophy; Brain Damage, Chronic; Cerebellar Diseases; Epilepsy; Female; Humans; Phenytoin; Rad | 1978 |
Cerebellar atrophy in phenytoin-treated mentally retarded epileptics.
Topics: Adolescent; Adult; Atrophy; Cerebellum; Child; Child, Preschool; Epilepsy; Female; Humans; Intellect | 1977 |
Phenytoin prevents stress- and corticosterone-induced atrophy of CA3 pyramidal neurons.
Topics: Adrenal Glands; Animals; Atrophy; Body Weight; Corticosterone; Dendrites; Hippocampus; Male; Neurons | 1992 |
Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Atrophy; Carbamoyl-Phosphate Synthase (Ammonia | 1992 |
Changes in serum glucocorticoid levels and thymic atrophy induced by phenytoin administration in mice.
Topics: Animals; Atrophy; Glucocorticoids; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Organ | 1991 |
Development of posttraumatic epilepsy.
Topics: Adolescent; Adult; Aged; Alcoholism; Atrophy; Brain Injuries; Carbamazepine; Cerebral Cortex; Cerebr | 1990 |
Cerebellar atrophy following acute intoxication with phenytoin.
Topics: Atrophy; Cerebellum; Humans; Magnetic Resonance Imaging; Phenytoin; Tomography, X-Ray Computed | 1990 |
Role of the cerebellum in complex human behavior.
Topics: Adult; Atrophy; Behavior; Cerebellum; Cognition Disorders; Epilepsy; Humans; Intelligence Tests; Neu | 1989 |
Cerebellar atrophy following acute intoxication with phenytoin.
Topics: Adult; Atrophy; Cerebellar Diseases; Cerebellum; Humans; Male; Phenytoin; Tomography, X-Ray Computed | 1989 |
Phenytoin neuropathy: structural changes in the sural nerve.
Topics: Atrophy; Axons; Electrodiagnosis; Humans; Male; Microscopy, Electron; Middle Aged; Peripheral Nerves | 1986 |
[Cerebellar injury caused by phenytoin].
Topics: Atrophy; Cerebellum; Humans; Phenytoin | 1986 |
Folic acid concentrations in cerebrospinal fluid in relation to anticonvulsant drugs and cerebral atrophy.
Topics: Adult; Anticonvulsants; Atrophy; Brain Diseases; Epilepsy; Female; Folic Acid; Humans; Male; Mental | 1971 |