Page last updated: 2024-10-21

phenytoin and Atrophy

phenytoin has been researched along with Atrophy in 50 studies

Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.

Research Excerpts

ExcerptRelevanceReference
"Chronic intoxication of phenytoin (PHT) is a well known cause of cerebellar atrophy or irreversible cerebellar ataxia."8.78[Cerebellar atrophy and persistent cerebellar ataxia after acute intoxication of phenytoin]. ( Ejima, A; Imamura, T; Sahara, M; Saito, H; Tsuburaya, K, 1992)
"Phenytoin is known to be able to induce cerebellar atrophy in patients with epilepsy."7.79The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy. ( Borgio, JG; De Paola, L; Scola, RH; Silvado, C; Twardowschy, CA; Werneck, LC, 2013)
"A 44-year-old man with treated neurosyphilis presented with subclinical status epilepticus (SE) refractory to intravenous high-dose lorazepam, phenytoin, and valproic acid over 4 days."7.72Ketamine for refractory status epilepticus: a case of possible ketamine-induced neurotoxicity. ( Lerner, AJ; Maddux, BN; Sagar, SM; Suarez, JI; Ubogu, EE; Werz, MA, 2003)
" The purpose of this study was to investigate the afferent fiber system to the cerebellum in patients with phenytoin (PHT)-induced cerebellar atrophy in comparison with cerebellar atrophy of other etiologies by using DT-MRI."7.72Diffusion tensor MRI and fiber tractography of cerebellar atrophy in phenytoin users. ( Chu, M; Heo, K; Kim, DI; Kim, DJ; Kim, SY; Lee, BI; Lee, SK; Mori, S, 2003)
"A 30-year-old man was given high doses of phenytoin together with 4 antituberculous drugs for a seizure associated with a probable brain tuberculoma."7.70[Residual cerebellar ataxia following acute phenytoin intoxication]. ( al Beladi, K; al Jumah, M; Amene, P; Awada, A, 1999)
"The chronic treatment with phenytoin or the acute intoxication by this drug may cause permanent cerebellar injury with atrophy of cerebellum vermis and hemispheres, which can be detected by neuroimaging studies."7.70[Dose-dependent relationship of chronic use of phenytoin and cerebellar atrophy in patients with epilepsy]. ( Cendes, F; Dantas, CD; Del Negro, A; Montenegro, MA; Zanardi, V, 2000)
"There is some evidence that long-term phenytoin (PHT) use may occasionally give rise to irreversible cerebellar atrophy, but it is unclear whether such changes can occur after acute PHT intoxication."7.69Cerebellar atrophy after acute phenytoin intoxication. ( Bharucha, NE; Kuruvilla, T, 1997)
"Thirty-six patients with partial epilepsy and long-term phenytoin exposure were selected from a consecutive sample of admissions to an epilepsy center."7.69Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy. ( Barr, WB; Lantos, G; Ney, GC; Schaul, N, 1994)
"Valproic acid induced coma is presented in an adult patient without a history of metabolic disease."7.68Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. ( Colombo, JP; Straver, JS; van der Vijver, JC; van Woerkom, TC; Verbiest, HB, 1992)
"A patient developed marked cerebellar atrophy after a single suicidal intoxication with 7 grams phenytoin."7.67Cerebellar atrophy following acute intoxication with phenytoin. ( Elger, CE; Galanski, M; Ludolph, AC; Masur, H, 1989)
" Using accepted CT criteria for the diagnosis of cerebellar atrophy, the films were analyzed in a blind, unbiased fashion to evaluate possible relationship between cerebellar atrophy and phenytoin use or epilepsy itself."7.66Cerebellar atrophy in epilepsy and headache: lack of relationship to phenytoin. ( Ballenger, CE; Brooks, BS; El Gammal, T; Green, JB; King, DW; Lucke, JF, 1982)
"Phenytoin, given to a cat in proportions therapeutic for man (5 to 8 mg/kg), induced severe dermal atrophy with excessive fragility of the skin following daily oral administration for 3 weeks."7.66Reversible dermal atrophy in a cat treated with phenytoin. ( Barthold, SW; Kaplan, BJ; Schwartz, A, 1980)
"The relationship among the serum concentration of phenytoin, pneumoencephalographic measurements describing, in particular, cerebellar atrophy, and various other clinical variables was analyzed statistically in a series of 131 phenytoin-treated mentally retarded epileptics."7.65Cerebellar atrophy in phenytoin-treated mentally retarded epileptics. ( Helle, EP; Iivanainen, M; Viukari, M, 1977)
"Phenytoin has been considered a possible cause of cerebellar degeneration, especially after clinical intoxication."5.29[Cerebellar atrophy and phenytoin poisoning. An MR study]. ( Aichner, F; Bauer, G; Birbamer, G; Felber, S; Luef, G; Marosi, M, 1993)
"Chronic intoxication of phenytoin (PHT) is a well known cause of cerebellar atrophy or irreversible cerebellar ataxia."4.78[Cerebellar atrophy and persistent cerebellar ataxia after acute intoxication of phenytoin]. ( Ejima, A; Imamura, T; Sahara, M; Saito, H; Tsuburaya, K, 1992)
"Phenytoin is known to be able to induce cerebellar atrophy in patients with epilepsy."3.79The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy. ( Borgio, JG; De Paola, L; Scola, RH; Silvado, C; Twardowschy, CA; Werneck, LC, 2013)
"A 44-year-old man with treated neurosyphilis presented with subclinical status epilepticus (SE) refractory to intravenous high-dose lorazepam, phenytoin, and valproic acid over 4 days."3.72Ketamine for refractory status epilepticus: a case of possible ketamine-induced neurotoxicity. ( Lerner, AJ; Maddux, BN; Sagar, SM; Suarez, JI; Ubogu, EE; Werz, MA, 2003)
" The purpose of this study was to investigate the afferent fiber system to the cerebellum in patients with phenytoin (PHT)-induced cerebellar atrophy in comparison with cerebellar atrophy of other etiologies by using DT-MRI."3.72Diffusion tensor MRI and fiber tractography of cerebellar atrophy in phenytoin users. ( Chu, M; Heo, K; Kim, DI; Kim, DJ; Kim, SY; Lee, BI; Lee, SK; Mori, S, 2003)
"A 30-year-old man was given high doses of phenytoin together with 4 antituberculous drugs for a seizure associated with a probable brain tuberculoma."3.70[Residual cerebellar ataxia following acute phenytoin intoxication]. ( al Beladi, K; al Jumah, M; Amene, P; Awada, A, 1999)
"The chronic treatment with phenytoin or the acute intoxication by this drug may cause permanent cerebellar injury with atrophy of cerebellum vermis and hemispheres, which can be detected by neuroimaging studies."3.70[Dose-dependent relationship of chronic use of phenytoin and cerebellar atrophy in patients with epilepsy]. ( Cendes, F; Dantas, CD; Del Negro, A; Montenegro, MA; Zanardi, V, 2000)
" The stress-induced CA3 apical dendritic atrophy in subordinates was prevented by administering daily oral doses of the antiepileptic drug phenytoin (Dilantin, Sigma, St."3.69Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. ( Flügge, G; Fuchs, E; Magariños, AM; McEwen, BS, 1996)
"Thirty-six patients with partial epilepsy and long-term phenytoin exposure were selected from a consecutive sample of admissions to an epilepsy center."3.69Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy. ( Barr, WB; Lantos, G; Ney, GC; Schaul, N, 1994)
"There is some evidence that long-term phenytoin (PHT) use may occasionally give rise to irreversible cerebellar atrophy, but it is unclear whether such changes can occur after acute PHT intoxication."3.69Cerebellar atrophy after acute phenytoin intoxication. ( Bharucha, NE; Kuruvilla, T, 1997)
"Valproic acid induced coma is presented in an adult patient without a history of metabolic disease."3.68Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. ( Colombo, JP; Straver, JS; van der Vijver, JC; van Woerkom, TC; Verbiest, HB, 1992)
" Statistical analyses showed that group 2 had a longer history of epilepsy with a consequently longer duration of phenytoin (PHT) consumption."3.67Role of the cerebellum in complex human behavior. ( Attig, E; Botez, MI; Botez, T; Elie, R, 1989)
"A patient developed marked cerebellar atrophy after a single suicidal intoxication with 7 grams phenytoin."3.67Cerebellar atrophy following acute intoxication with phenytoin. ( Elger, CE; Galanski, M; Ludolph, AC; Masur, H, 1989)
" Using accepted CT criteria for the diagnosis of cerebellar atrophy, the films were analyzed in a blind, unbiased fashion to evaluate possible relationship between cerebellar atrophy and phenytoin use or epilepsy itself."3.66Cerebellar atrophy in epilepsy and headache: lack of relationship to phenytoin. ( Ballenger, CE; Brooks, BS; El Gammal, T; Green, JB; King, DW; Lucke, JF, 1982)
"The folic acid absorption test (FAAT) has carried out in 18 normal control subjects; 8 patients with proven atrophy of the jejunal mucosa; 7 patients with gastric ulcus; 17 patients with reactive hypoglycemia; 13 patients with diabetes mellitus, and, finally, 9 epileptic patients treated with diphenylhydantoin (DPH)."3.66Folic acid absorption test in various clinical conditions. ( Bachevalier, J; Botez, MI, 1981)
"Phenytoin, given to a cat in proportions therapeutic for man (5 to 8 mg/kg), induced severe dermal atrophy with excessive fragility of the skin following daily oral administration for 3 weeks."3.66Reversible dermal atrophy in a cat treated with phenytoin. ( Barthold, SW; Kaplan, BJ; Schwartz, A, 1980)
"The relationship among the serum concentration of phenytoin, pneumoencephalographic measurements describing, in particular, cerebellar atrophy, and various other clinical variables was analyzed statistically in a series of 131 phenytoin-treated mentally retarded epileptics."3.65Cerebellar atrophy in phenytoin-treated mentally retarded epileptics. ( Helle, EP; Iivanainen, M; Viukari, M, 1977)
"Most patients with cerebellar dysfunction have phenytoin concentrations above the reference range."2.82Phenytoin and damage to the cerebellum - a systematic review of published cases. ( Bradberry, SM; Day, R; Ferner, R, 2022)
"Limbic encephalitis is a rare central nervous system (CNS) manifestation of relapsing polychondritis (RP)."1.35Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis. ( Kashihara, K; Kawada, S; Takahashi, Y, 2009)
"Carbamazepine was given to 15 patients, phenytoin to 12, and barbiturate to 7, respectively; 42 patients also received corticosteroids."1.30Late radiation toxicity after whole brain radiotherapy: the influence of antiepileptic drugs. ( Leicht, A; Motaref, B; Nestle, U; Nieder, C; Niewald, M; Schnabel, K, 1999)
"Phenytoin has been considered a possible cause of cerebellar degeneration, especially after clinical intoxication."1.29[Cerebellar atrophy and phenytoin poisoning. An MR study]. ( Aichner, F; Bauer, G; Birbamer, G; Felber, S; Luef, G; Marosi, M, 1993)
"Phenytoin has been implicated as a causative agent in peripheral neuropathy, although structural changes in nerve have not been characterized."1.27Phenytoin neuropathy: structural changes in the sural nerve. ( Griggs, RC; Mendell, JR; Ramirez, JA; Warmolts, JR, 1986)
"Reversible cerebellar dysfunction is a common manifestation of acute phenytoin toxicity."1.26[Diphenylhydantoin, epilepsy, cerebellar atrophy--histological and electron microscope examinations (author's transl)]. ( Breiden-Arends, C; Gullotta, F, 1981)

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-199020 (40.00)18.7374
1990's18 (36.00)18.2507
2000's8 (16.00)29.6817
2010's3 (6.00)24.3611
2020's1 (2.00)2.80

Authors

AuthorsStudies
Ferner, R1
Day, R1
Bradberry, SM1
Xu, C1
Wang, Y2
Zhang, S1
Nao, J1
Liu, Y1
Ding, F1
Zhong, K1
Chen, L1
Ying, X1
Wang, S1
Zhou, Y1
Duan, S1
Chen, Z1
Brown, ES1
Lu, H1
Denniston, D1
Uh, J1
Thomas, BP1
Carmody, TJ1
Auchus, RJ1
Diaz-Arrastia, R1
Tamminga, C1
Kashihara, K1
Kawada, S1
Takahashi, Y1
Twardowschy, CA1
Werneck, LC1
Scola, RH1
Borgio, JG1
De Paola, L1
Silvado, C1
Ubogu, EE1
Sagar, SM1
Lerner, AJ1
Maddux, BN1
Suarez, JI1
Werz, MA1
OKUDA, O1
SHINOHARA, S1
Lee, SK1
Mori, S1
Kim, DJ1
Kim, SY2
Chu, M1
Heo, K1
Lee, BI1
Kim, DI1
Chow, KM1
Szeto, CC1
Feuerstein, T1
von Reutern, GM1
Cramer, H1
Lindvall, O1
Nilsson, B1
Procházková, V1
Urban, P1
Roman, EJ1
Buchanan, N1
Lambert, JB1
Barrah, N1
Baier, WK1
Beck, U1
Doose, H1
Klinge, H1
Hirsch, W1
Koller, WC1
Glatt, SL1
Perlik, S1
Huckman, MS1
Fox, JH1
Claus, D1
Aschoff, JC1
Ballenger, CE1
Lucke, JF1
King, DW1
El Gammal, T1
Brooks, BS1
Green, JB1
Botez, MI2
Bachevalier, J1
Breiden-Arends, C1
Gullotta, F1
McLain, LW1
Martin, JT1
Allen, JH1
Barthold, SW1
Kaplan, BJ1
Schwartz, A1
Theodore, WH1
Luef, G2
Chemelli, A1
Birbamer, G2
Aichner, F2
Bauer, G2
Ney, GC1
Lantos, G1
Barr, WB1
Schaul, N1
Ringo, JL1
Marosi, M1
Felber, S1
Blumberg, HP1
Kanwal, GS1
Relkin, N1
Mattis, S1
Viederman, M1
Makari, GJ1
Magariños, AM1
McEwen, BS2
Flügge, G1
Fuchs, E1
Kuruvilla, T1
Bharucha, NE1
Errea-Abad, JM1
González-Igual, J1
Eito-Cativiela, JL1
Gastón-Añaños, J1
Awada, A1
Amene, P1
al Jumah, M1
al Beladi, K1
Fujimoto, K1
Nakano, I1
Nieder, C1
Leicht, A1
Motaref, B1
Nestle, U1
Niewald, M1
Schnabel, K1
Hironishi, M1
Del Negro, A1
Dantas, CD1
Zanardi, V1
Montenegro, MA1
Cendes, F1
Alioğlu, Z1
Sari, A1
Velioğlu, SK1
Ouml;zmenoğlu, M1
Tan, EK1
Chan, LL1
Auchus, AP1
Heim, M1
Morgner, J1
Iivanainen, M1
Viukari, M1
Helle, EP1
Watanabe, Y1
Gould, E1
Cameron, HA1
Daniels, DC1
Verbiest, HB1
Straver, JS1
Colombo, JP1
van der Vijver, JC1
van Woerkom, TC1
Imamura, T1
Ejima, A1
Sahara, M1
Saito, H1
Tsuburaya, K1
Hirai, M1
Ichikawa, M1
Heikkinen, ER1
Rönty, HS1
Tolonen, U1
Pyhtinen, J1
Masur, H2
Fahrendorf, G1
Oberwittler, C1
Reuther, G1
Botez, T1
Elie, R1
Attig, E1
Elger, CE1
Ludolph, AC1
Galanski, M1
Ramirez, JA1
Mendell, JR1
Warmolts, JR1
Griggs, RC1
Bechinger, D1
Klotz, R1
Kornhuber, HH1
Jensen, ON1
Olesen, OV1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Study to Assess the Efficacy of Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy[NCT05019885]Phase 26 participants (Anticipated)Interventional2022-08-26Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for phenytoin and Atrophy

ArticleYear
Phenytoin and damage to the cerebellum - a systematic review of published cases.
    Expert opinion on drug safety, 2022, Volume: 21, Issue:7

    Topics: Adult; Ataxia; Atrophy; Cerebellar Ataxia; Cerebellar Diseases; Cerebellum; Humans; Phenytoin

2022
[Acquired cortical cerebellar atrophy].
    Ryoikibetsu shokogun shirizu, 1999, Issue:27 Pt 2

    Topics: Alcoholism; Anticonvulsants; Antidepressive Agents; Antineoplastic Agents; Atrophy; Bromisovalum; Ce

1999
[Cerebellar atrophy and persistent cerebellar ataxia after acute intoxication of phenytoin].
    No to shinkei = Brain and nerve, 1992, Volume: 44, Issue:2

    Topics: Adult; Atrophy; Cerebellar Ataxia; Cerebellum; Humans; Male; Phenytoin; Tomography, X-Ray Computed

1992

Trials

1 trial available for phenytoin and Atrophy

ArticleYear
A randomized, placebo-controlled proof-of-concept, crossover trial of phenytoin for hydrocortisone-induced declarative memory changes.
    Journal of affective disorders, 2013, Sep-05, Volume: 150, Issue:2

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Atrophy; Cross-Over Studies; Double-Blind Method; Femal

2013

Other Studies

46 other studies available for phenytoin and Atrophy

ArticleYear
Subicular pyramidal neurons gate drug resistance in temporal lobe epilepsy.
    Annals of neurology, 2019, Volume: 86, Issue:4

    Topics: Animals; Atrophy; Clozapine; Drug Resistant Epilepsy; Electric Stimulation; Epilepsy, Temporal Lobe;

2019
Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis.
    Journal of the neurological sciences, 2009, Dec-15, Volume: 287, Issue:1-2

    Topics: Amygdala; Anti-Inflammatory Agents; Anticonvulsants; Atrophy; Autoantibodies; Biomarkers; Brain; Car

2009
The role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy.
    Seizure, 2013, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Aged; Alleles; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Atrophy; Cerebella

2013
Ketamine for refractory status epilepticus: a case of possible ketamine-induced neurotoxicity.
    Epilepsy & behavior : E&B, 2003, Volume: 4, Issue:1

    Topics: Adult; Anticonvulsants; Atrophy; Brain; Electroencephalography; Excitatory Amino Acid Antagonists; H

2003
[OBSERVATION ON TWO CASES OF EPILEPSIA CURSIVA].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1964, Volume: 66

    Topics: Adolescent; Atrophy; Barbiturates; Cerebral Cortex; Chlordiazepoxide; Dichlorphenamide; Electroencep

1964
Diffusion tensor MRI and fiber tractography of cerebellar atrophy in phenytoin users.
    Epilepsia, 2003, Volume: 44, Issue:12

    Topics: Adult; Afferent Pathways; Anisotropy; Anticonvulsants; Atrophy; Cerebellum; Diagnosis, Differential;

2003
Cerebral atrophy and skull thickening due to chronic phenytoin therapy.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2007, Jan-30, Volume: 176, Issue:3

    Topics: Adult; Anticonvulsants; Atrophy; Cerebellar Diseases; Diagnosis, Differential; Epilepsy; Female; Hum

2007
[Phenytoin poisoning in a degradation disorder, report of a case with cerebellar atrophy].
    Der Nervenarzt, 1983, Volume: 54, Issue:2

    Topics: Adult; Atrophy; Cerebellar Ataxia; Cerebellum; Cholestyramine Resin; Electroencephalography; Epileps

1983
Cerebellar atrophy following phenytoin intoxication.
    Annals of neurology, 1984, Volume: 16, Issue:2

    Topics: Adult; Atrophy; Cerebellar Ataxia; Cerebellum; Humans; Male; Phenytoin; Tomography, X-Ray Computed

1984
[Hydantoin atrophy (degeneration) of the cerebellum].
    Ceskoslovenska neurologie a neurochirurgie, 1984, Volume: 47, Issue:4

    Topics: Adolescent; Adult; Atrophy; Cerebellar Diseases; Female; Humans; Male; Phenytoin

1984
Rationalisation of therapy in severe epilepsy.
    Australian and New Zealand journal of medicine, 1983, Volume: 13, Issue:6

    Topics: Adult; Anticonvulsants; Arousal; Atrophy; Cerebellum; Drug Administration Schedule; Drug Therapy, Co

1983
Cerebellar atrophy following diphenylhydantoin intoxication.
    Neuropediatrics, 1984, Volume: 15, Issue:2

    Topics: Adolescent; Atrophy; Cerebellum; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Ph

1984
Cerebellar atrophy demonstrated by computed tomography.
    Neurology, 1981, Volume: 31, Issue:4

    Topics: Adult; Alcoholism; Atrophy; Carcinoma; Cerebellar Diseases; Cerebellar Neoplasms; Cerebral Ventricul

1981
Evaluation of infratentorial atrophy by computed tomography.
    Journal of neurology, neurosurgery, and psychiatry, 1982, Volume: 45, Issue:11

    Topics: Adolescent; Adult; Aged; Alcoholism; Atrophy; Cerebellopontine Angle; Cerebellum; Cerebral Ventricle

1982
Cerebellar atrophy in epilepsy and headache: lack of relationship to phenytoin.
    Neurology, 1982, Volume: 32, Issue:8

    Topics: Adolescent; Adult; Atrophy; Cerebellum; Epilepsy; Female; Headache; Humans; Male; Phenytoin; Tomogra

1982
Folic acid absorption test in various clinical conditions.
    Annals of nutrition & metabolism, 1981, Volume: 25, Issue:6

    Topics: Adult; Aged; Atrophy; Diabetes Mellitus; Epilepsy; Folic Acid; Gastrointestinal Diseases; Humans; Hy

1981
[Diphenylhydantoin, epilepsy, cerebellar atrophy--histological and electron microscope examinations (author's transl)].
    Fortschritte der Neurologie-Psychiatrie, 1981, Volume: 49, Issue:11

    Topics: Adult; Atrophy; Cerebellar Diseases; Cerebellum; Endoplasmic Reticulum; Epilepsy; Female; Humans; Ma

1981
Cerebellar degeneration due to chronic phenytoin therapy.
    Annals of neurology, 1980, Volume: 7, Issue:1

    Topics: Adult; Atrophy; Cerebellar Diseases; Female; Humans; Male; Middle Aged; Phenytoin; Seizures; Tomogra

1980
Reversible dermal atrophy in a cat treated with phenytoin.
    Veterinary pathology, 1980, Volume: 17, Issue:4

    Topics: Administration, Oral; Animals; Atrophy; Cat Diseases; Cats; Collagen Diseases; Male; Phenytoin; Skin

1980
Phenytoin and cerebellar atrophy.
    Archives of neurology, 1995, Volume: 52, Issue:3

    Topics: Atrophy; Cerebellum; Humans; Phenytoin; Seizures

1995
Phenytoin overdosage and cerebellar atrophy in epileptic patients: clinical and MRI findings.
    European neurology, 1994, Volume: 34 Suppl 1

    Topics: Adult; Atrophy; Cerebellar Diseases; Cerebellum; Drug Overdose; Epilepsy; Female; Humans; Magnetic R

1994
Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy.
    Archives of neurology, 1994, Volume: 51, Issue:8

    Topics: Adult; Atrophy; Cerebellum; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin

1994
The medial temporal lobe in encoding, retention, retrieval and interhemispheric transfer of visual memory in primates.
    Experimental brain research, 1993, Volume: 96, Issue:3

    Topics: Animals; Atrophy; Brain Mapping; Corpus Callosum; Discrimination, Psychological; Electric Stimulatio

1993
[Cerebellar atrophy and phenytoin poisoning. An MR study].
    Der Nervenarzt, 1993, Volume: 64, Issue:8

    Topics: Adult; Anticonvulsants; Atrophy; Cerebellar Ataxia; Cerebellum; Dose-Response Relationship, Drug; Dr

1993
Psychiatric complications in a patient with complex partial seizures.
    The American journal of psychiatry, 1996, Volume: 153, Issue:3

    Topics: Atrophy; Brain; Brain Diseases; Comorbidity; Epilepsy, Complex Partial; Humans; Magnetic Resonance I

1996
Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, May-15, Volume: 16, Issue:10

    Topics: Animals; Atrophy; Body Weight; Dendrites; Hippocampus; Hydrocortisone; Male; Phenytoin; Pyramidal Ce

1996
Cerebellar atrophy after acute phenytoin intoxication.
    Epilepsia, 1997, Volume: 38, Issue:4

    Topics: Acute Disease; Adult; Atrophy; Cerebellar Diseases; Cerebellum; Drug Overdose; Humans; Magnetic Reso

1997
[Acute phenytoin poisoning due to its interaction with fluoropyramidine].
    Revista de neurologia, 1998, Volume: 27, Issue:160

    Topics: Acute Disease; Aged; Anticonvulsants; Atrophy; Brain; Drug Interactions; Humans; Magnetic Resonance

1998
[Residual cerebellar ataxia following acute phenytoin intoxication].
    Revue neurologique, 1999, Volume: 155, Issue:4

    Topics: Adult; Anticonvulsants; Atrophy; Brain; Brain Neoplasms; Cerebellar Ataxia; Cerebellum; Epilepsy; Hu

1999
Late radiation toxicity after whole brain radiotherapy: the influence of antiepileptic drugs.
    American journal of clinical oncology, 1999, Volume: 22, Issue:6

    Topics: Actuarial Analysis; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anticonvulsants; Atrophy;

1999
[Cerebellar atrophy associated with phenytoin intoxication].
    No to shinkei = Brain and nerve, 2000, Volume: 52, Issue:3

    Topics: Adult; Atrophy; Cerebellar Diseases; Humans; Male; Phenytoin; Poisoning

2000
[Dose-dependent relationship of chronic use of phenytoin and cerebellar atrophy in patients with epilepsy].
    Arquivos de neuro-psiquiatria, 2000, Volume: 58, Issue:2A

    Topics: Adult; Anticonvulsants; Atrophy; Cerebellum; Dose-Response Relationship, Drug; Epilepsy; Female; Hum

2000
Cerebellar atrophy following acute phenytoin intoxication.
    Journal of neuroradiology = Journal de neuroradiologie, 2000, Volume: 27, Issue:1

    Topics: Acute Disease; Adult; Anticonvulsants; Atrophy; Cerebellum; Female; Humans; Phenytoin

2000
Phenytoin cerebellopathy without epilepsy.
    Acta neurologica Scandinavica, 2001, Volume: 104, Issue:1

    Topics: Anticonvulsants; Atrophy; Cerebellar Diseases; Female; Humans; Middle Aged; Motor Skills Disorders;

2001
[Toxic "atrophie cerebelleuse". (problems associated with permanent cerebellar damage due to chronic diphenylhydantion intoxication)].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1978, Volume: 30, Issue:3

    Topics: Adult; Atrophy; Brain Damage, Chronic; Cerebellar Diseases; Epilepsy; Female; Humans; Phenytoin; Rad

1978
Cerebellar atrophy in phenytoin-treated mentally retarded epileptics.
    Epilepsia, 1977, Volume: 18, Issue:3

    Topics: Adolescent; Adult; Atrophy; Cerebellum; Child; Child, Preschool; Epilepsy; Female; Humans; Intellect

1977
Phenytoin prevents stress- and corticosterone-induced atrophy of CA3 pyramidal neurons.
    Hippocampus, 1992, Volume: 2, Issue:4

    Topics: Adrenal Glands; Animals; Atrophy; Body Weight; Corticosterone; Dendrites; Hippocampus; Male; Neurons

1992
Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.
    Acta neurologica Scandinavica, 1992, Volume: 86, Issue:3

    Topics: Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Atrophy; Carbamoyl-Phosphate Synthase (Ammonia

1992
Changes in serum glucocorticoid levels and thymic atrophy induced by phenytoin administration in mice.
    Toxicology letters, 1991, Volume: 56, Issue:1-2

    Topics: Animals; Atrophy; Glucocorticoids; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Organ

1991
Development of posttraumatic epilepsy.
    Stereotactic and functional neurosurgery, 1990, Volume: 54-55

    Topics: Adolescent; Adult; Aged; Alcoholism; Atrophy; Brain Injuries; Carbamazepine; Cerebral Cortex; Cerebr

1990
Cerebellar atrophy following acute intoxication with phenytoin.
    Neurology, 1990, Volume: 40, Issue:11

    Topics: Atrophy; Cerebellum; Humans; Magnetic Resonance Imaging; Phenytoin; Tomography, X-Ray Computed

1990
Role of the cerebellum in complex human behavior.
    Italian journal of neurological sciences, 1989, Volume: 10, Issue:3

    Topics: Adult; Atrophy; Behavior; Cerebellum; Cognition Disorders; Epilepsy; Humans; Intelligence Tests; Neu

1989
Cerebellar atrophy following acute intoxication with phenytoin.
    Neurology, 1989, Volume: 39, Issue:3

    Topics: Adult; Atrophy; Cerebellar Diseases; Cerebellum; Humans; Male; Phenytoin; Tomography, X-Ray Computed

1989
Phenytoin neuropathy: structural changes in the sural nerve.
    Annals of neurology, 1986, Volume: 19, Issue:2

    Topics: Atrophy; Axons; Electrodiagnosis; Humans; Male; Microscopy, Electron; Middle Aged; Peripheral Nerves

1986
[Cerebellar injury caused by phenytoin].
    Deutsche medizinische Wochenschrift (1946), 1986, Feb-07, Volume: 111, Issue:6

    Topics: Atrophy; Cerebellum; Humans; Phenytoin

1986
Folic acid concentrations in cerebrospinal fluid in relation to anticonvulsant drugs and cerebral atrophy.
    Acta psychiatrica Scandinavica, 1971, Volume: 47, Issue:2

    Topics: Adult; Anticonvulsants; Atrophy; Brain Diseases; Epilepsy; Female; Folic Acid; Humans; Male; Mental

1971