Page last updated: 2024-10-21

phenytoin and Ataxia

phenytoin has been researched along with Ataxia in 89 studies

Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.

Research Excerpts

ExcerptRelevanceReference
"Cerebellar ataxia is present in 40% of patients with epilepsy and chronic exposure to phenytoin."7.88Phenytoin-related ataxia in patients with epilepsy: clinical and radiological characteristics. ( Aeschlimann, DP; Aeschlimann, PC; Dennis, GJ; Grünewald, RA; Hadjivassiliou, M; Hoggard, N; Howell, SJ; Reuber, M; Shanmugarajah, PD, 2018)
"Acute ataxia is commonly the chief complaint among patients visiting the emergency department (ED)."5.72A Phenytoin-Induced Ataxia Mimicking a Stroke. ( Urushidani, S, 2022)
"We present the case of a 77 year old man who had been treated for twenty years with phenytoin for partial crises secondary to a left frontal hematoma."4.80[Acute phenytoin poisoning secondary to an interaction with ticlopidine]. ( López-Ariztegui, N; Martín, M; Nevado, C; Ochoà, M; Sánchez-Migallón, MJ, 1998)
"Cerebellar ataxia is present in 40% of patients with epilepsy and chronic exposure to phenytoin."3.88Phenytoin-related ataxia in patients with epilepsy: clinical and radiological characteristics. ( Aeschlimann, DP; Aeschlimann, PC; Dennis, GJ; Grünewald, RA; Hadjivassiliou, M; Hoggard, N; Howell, SJ; Reuber, M; Shanmugarajah, PD, 2018)
" When fluconazole, a potent inhibitor of CYP2C9, was added to the treatment regimen, the patient developed ataxia, tremor, fatigue, slurred speech and somnolence, indicating phenytoin intoxication."3.76Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9. ( Bergman, U; Bertilsson, L; Engström Hellgren, K; Helldén, A; Masquelier, M; Nilsson Remahl, I; Odar-Cederlöf, I; Ramsjö, M, 2010)
"Colchicine poisoning is an uncommon, but potentially life-threatening, toxicologic emergency."3.74Acute colchicine intoxication in a child: a case report. ( Biçer, S; Ctak, A; Karaböcüoğlu, M; Soysal, DD; Uçsel, R; Uzel, N, 2007)
"Aromatic and heterocyclic esters of 1-methyl-4-piperidinol and 1,4-dimethyl-4-piperidinol and aromatic esters of (dialkylamino)alkanols were prepared and evaluated for antiepileptic activity by the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (scMet) assays and for minimal central neurotoxicity by the rotorod ataxia test."3.67Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters. ( Creveling, CR; Daly, JW; Hollingsworth, EB; Lewandowski, G; Waters, JA, 1986)
"A young epileptic presented with spasticity as well as ataxia, diplopia and nystagmus; his serum phenytoin level was very high."3.66Spasticity due to phenytoin toxicity. ( Stark, RJ, 1979)
"Two patients with intractable epilepsy who had been treated with various combinations of anticonvulsant drugs developed phenytoin encephalopathy."3.65Choreo-athetosis and encephalopathy induced by phenytoin. ( McLellan, DL; Swash, M, 1974)
"Clinical signs of ataxia can persist without radiological evidence of cerebellar atrophy, and cerebellar atrophy is seen without any clinical evidence of cerebellar dysfunction."2.82Phenytoin and damage to the cerebellum - a systematic review of published cases. ( Bradberry, SM; Day, R; Ferner, R, 2022)
"Acute ataxia is commonly the chief complaint among patients visiting the emergency department (ED)."1.72A Phenytoin-Induced Ataxia Mimicking a Stroke. ( Urushidani, S, 2022)
"This case suggests that dysphagia related to phenytoin-induced lymphoid hypertrophy may be treated by phenytoin discontinuation followed by a sufficient amount of time to allow symptom resolution rather than by prompt surgery."1.46Velopharyngeal Incoordination Caused by Phenytoin-Induced Toxicity. ( Hwang, CH, 2017)
"1 microg/mL when fluvoxamine was coadministered, although the daily dosage of phenytoin and other drugs had not changed."1.31Phenytoin intoxication induced by fluvoxamine. ( Higuchi, S; Ieiri, I; Kojima, K; Mamiya, K; Ninomiya, H; Tashiro, N; Yukawa, E, 2001)
"In rats aged 18 days or less ataxia of hindlimbs was also marked."1.27Convulsant action of diphenylhydantoin overdose in young rats. ( Lisková-Bernásková, K; Mares, P; Mudrochová, M, 1987)

Research

Studies (89)

TimeframeStudies, this research(%)All Research%
pre-199069 (77.53)18.7374
1990's6 (6.74)18.2507
2000's4 (4.49)29.6817
2010's8 (8.99)24.3611
2020's2 (2.25)2.80

Authors

AuthorsStudies
Pavia, MR3
Lobbestael, SJ3
Taylor, CP3
Hershenson, FM2
Miskell, DL1
Waters, JA1
Hollingsworth, EB1
Daly, JW1
Lewandowski, G1
Creveling, CR1
Ferner, R1
Day, R1
Bradberry, SM1
Urushidani, S1
Shanmugarajah, PD1
Hoggard, N1
Aeschlimann, DP1
Aeschlimann, PC1
Dennis, GJ1
Howell, SJ1
Reuber, M1
Grünewald, RA1
Hadjivassiliou, M1
Watters, M1
Wilson, H1
Everitt, P1
Burns, JM1
Marino, A1
Manno, M1
Rhyee, S1
Boyer, EW1
Zappia, CP1
Piccirillo, B1
Hwang, CH1
Helldén, A1
Bergman, U1
Engström Hellgren, K1
Masquelier, M1
Nilsson Remahl, I1
Odar-Cederlöf, I1
Ramsjö, M1
Bertilsson, L1
Shimizu, T1
Ambrose, T1
Chandra, N1
DAVIS, MA1
WINTHROP, SO1
THOMAS, RA1
HERR, F1
CHAREST, MP1
GAUDRY, R1
KUTT, H7
WINTERS, W3
KOKENGE, R2
MCDOWELL, F5
SCHERMAN, R1
KISHI, Y1
MANMARU, S1
FUKUI, S1
AOKI, Y1
SNYDER, CH1
Biçer, S1
Soysal, DD1
Ctak, A1
Uçsel, R1
Karaböcüoğlu, M1
Uzel, N1
Hansen, OE2
Lund, MA1
Perez del Cerro, M1
Snider, RS1
Frantzen, E1
Hansen, JM1
Kristensen, M1
Berger, JR1
Kovacs, AG1
Gore, JM1
Haffajee, CI1
Alpert, JS1
Skillrud, DM1
Goldstein, NP1
Solomon, JG1
Ikeda, H1
Vincent, FM1
Garson, A1
Kugler, JD1
Gillette, PC1
Simonelli, A1
McNamara, DG1
Abe, K1
Okano, M1
Sasaki, H1
Young, GB1
Oppenheimer, SR1
Gordon, BA1
Wells, GA1
Assis, LP1
Kreeft, JH1
Lohuis, NA1
Blume, WT1
Katz, AA1
Hoffman, RS1
Silverman, RA1
Fleishaker, JC1
Pearson, LK1
Peters, GR1
López-Ariztegui, N1
Ochoà, M1
Sánchez-Migallón, MJ1
Nevado, C1
Martín, M1
Sharma, S1
Dasroy, SK1
Mamiya, K1
Kojima, K1
Yukawa, E1
Higuchi, S1
Ieiri, I1
Ninomiya, H1
Tashiro, N1
Stark, RJ1
Boldyrev, AI1
Fleĭs, EP1
Vaĭntrub, MIa1
Shakir, RA1
Nanda, RN1
Lambie, DG1
Johnson, RH1
Troupin, A1
Ojemann, LM1
Halpern, L1
Dodrill, C1
Wilkus, R1
Friel, P1
Feigl, P1
Beier, R1
Zschiesche, M1
Cammann, R1
Krüger, H1
Glötzner, FL1
Samland, O1
Dommasch, D1
Shapira, Y1
Cederbaum, SD1
Cancilla, PA1
Nielsen, D1
Lippe, BM1
Livingston, S1
Berman, W1
Pauli, LL1
Onuma, T1
Mares, P1
Lisková-Bernásková, K1
Mudrochová, M1
Finestone, AJ1
Williams, FF1
Glogner, P1
Vessell, ES1
Passananti, GT1
Clow, D1
Stephenson, JB1
Logan, RW1
Jamieson, EC1
Gauchel, FD1
Lehr, HJ1
Gauchel, G1
von Harnack, GA1
McLellan, DL1
Swash, M1
Lund, L1
Breithardt, G1
Loogen, F1
Seipel, L1
Edwards, VE1
Critchley, EM1
Clark, DB1
Wikler, A1
Brittain, RT1
Landy, PJ1
Igata, A1
Murphy, MJ1
Goldstein, MN1
Shuttleworth, E1
Wise, G1
Paulson, G1
Booker, HE1
Darcey, B1
Gallagher, BB1
Baumel, IP1
Mattson, RH1
Woodbury, SG1
Juul-Jensen, P1
Schou, M1
Kooiker, JC1
Sumi, SM1
Hopkins, IJ1
Rooney, JC1
Ang, MK1
Guiang, R1
Berger, AR1
Melchior, JC1
Buchthal, F1
Lennox-Buchthal, M1
Holcomb, R1
Lynn, R1
Harvey, B1
Sweetman, BJ1
Gerber, N1
Fischer, KC1
Wilson, WP1
Behrman, S1
Viukari, NM2
Aho, K1
Brennan, RW1
Dehejia, H1
Verebely, K1
Kalensky, J1
Herzka, HS1
Allen, CD1
Klipstein, FA1
Patel, H1
Crichton, JU1
Pifferi, G1
Consonni, P1
Banfi, S1
Diena, A1
Gordon, N1
Garrettson, LK1
Perel, JM1
Dayton, PG1
McDowell, FH1

Reviews

6 reviews available for phenytoin and Ataxia

ArticleYear
Phenytoin and damage to the cerebellum - a systematic review of published cases.
    Expert opinion on drug safety, 2022, Volume: 21, Issue:7

    Topics: Adult; Ataxia; Atrophy; Cerebellar Ataxia; Cerebellar Diseases; Cerebellum; Humans; Phenytoin

2022
[Acute phenytoin poisoning secondary to an interaction with ticlopidine].
    Revista de neurologia, 1998, Volume: 26, Issue:154

    Topics: Acute Disease; Aged; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Ataxia; Cerebrovascular Disorde

1998
Biochemical and genetic factors regulating dilantin metabolism in man.
    Annals of the New York Academy of Sciences, 1971, Jul-06, Volume: 179

    Topics: Aminosalicylic Acids; Animals; Ataxia; Cats; Chlordan; Cycloserine; DDT; Dicumarol; Disulfiram; Enzy

1971
Utility of clinical chemical determinations of drug concentrations in biological fluids.
    Clinical chemistry, 1971, Volume: 17, Issue:9

    Topics: Adult; Allopurinol; Antipyrine; Ataxia; Chemistry, Clinical; Chromatography, Gas; Coffee; Desipramin

1971
[Long-term treatment of arrhythmias].
    Zeitschrift fur Kardiologie, 1974, Volume: 63, Issue:3

    Topics: Ajmaline; Arrhythmias, Cardiac; Ataxia; Electric Countershock; Gastrointestinal Diseases; Humans; Li

1974
[Ataxia associated with infections and toxicosis].
    Nihon rinsho. Japanese journal of clinical medicine, 1971, Volume: 29, Issue:8

    Topics: Abdomen; Adult; Animals; Ataxia; Cerebellar Ataxia; Cerebrovascular Disorders; Demyelinating Disease

1971

Trials

2 trials available for phenytoin and Ataxia

ArticleYear
Induction of tirilazad clearance by phenytoin.
    Biopharmaceutics & drug disposition, 1998, Volume: 19, Issue:2

    Topics: Adult; Anticonvulsants; Antioxidants; Ataxia; Cross-Over Studies; Dizziness; Dose-Response Relations

1998
Carbamazepine--a double-blind comparison with phenytoin.
    Neurology, 1977, Volume: 27, Issue:6

    Topics: Adult; Ataxia; Carbamazepine; Clinical Trials as Topic; Drug Evaluation; Epilepsies, Partial; Hemato

1977

Other Studies

81 other studies available for phenytoin and Ataxia

ArticleYear
N-phenyl-N'-pyridinylureas as anticonvulsant agents.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:2

    Topics: Administration, Oral; Animals; Anticonvulsants; Ataxia; Chemical Phenomena; Chemistry; Dose-Response

1990
6-Alkyl-N,N-disubstituted-2-pyridinamines as anticonvulsant agents.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:6

    Topics: Aminopyridines; Animals; Ataxia; Blepharoptosis; Chemical Phenomena; Chemistry; Electroshock; Kindli

1989
Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:8

    Topics: Amino Alcohols; Animals; Anticonvulsants; Ataxia; Bridged Bicyclo Compounds; Bridged Bicyclo Compoun

1986
6-Alkoxy-N,N-disubstituted-2-pyridinamines as anticonvulsant agents.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:7

    Topics: Animals; Anticonvulsants; Ataxia; Male; Mice; Rats; Structure-Activity Relationship

1987
A Phenytoin-Induced Ataxia Mimicking a Stroke.
    The American journal of emergency medicine, 2022, Volume: 60

    Topics: Ataxia; Carbamazepine; Female; Humans; Middle Aged; Phenytoin; Stroke; Valproic Acid

2022
Phenytoin-related ataxia in patients with epilepsy: clinical and radiological characteristics.
    Seizure, 2018, Volume: 56

    Topics: Antibodies; Anticonvulsants; Ataxia; Brain; Epilepsy; Female; Folic Acid; Gliadin; GTP-Binding Prote

2018
Phenytoin-induced hypothermia.
    BMJ case reports, 2019, Jan-22, Volume: 12, Issue:1

    Topics: Aftercare; Ataxia; Cytochrome P-450 CYP1A2 Inducers; Diagnosis, Differential; Humans; Hypothermia; L

2019
Status epilepticus in a child secondary to ingestion of skin-lightening cream.
    Pediatric emergency care, 2013, Volume: 29, Issue:5

    Topics: Anticonvulsants; Ataxia; Eating; Emergencies; Humans; Hydroquinones; Infant; Intubation, Intratrache

2013
Ataxia and dizziness in a patient on hemodialysis.
    JAAPA : official journal of the American Academy of Physician Assistants, 2014, Volume: 27, Issue:12

    Topics: Anticonvulsants; Ataxia; Dizziness; Humans; Kidney Failure, Chronic; Male; Middle Aged; Phenytoin; R

2014
Velopharyngeal Incoordination Caused by Phenytoin-Induced Toxicity.
    American journal of physical medicine & rehabilitation, 2017, Volume: 96, Issue:2

    Topics: Adult; Anticonvulsants; Ataxia; Deglutition Disorders; Gastroesophageal Reflux; Humans; Hypertrophy;

2017
Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:8

    Topics: Alleles; Angiotensin II Type 1 Receptor Blockers; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; At

2010
[Ataxia].
    Nihon rinsho. Japanese journal of clinical medicine, 2012, Volume: 70 Suppl 6

    Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Antipsychotic Agents; Ataxia; Fluorouracil; Humans

2012
The ataxic cirrhotic.
    Clinical medicine (London, England), 2012, Volume: 12, Issue:6

    Topics: Anticonvulsants; Ataxia; Female; Humans; Liver Cirrhosis, Alcoholic; Middle Aged; Phenytoin; Seizure

2012
ANTICONVULSANTS. I. DIBENZO(A,D)CYCLOHEPTADIENE-5-CARBOXAMIDE AND RELATED COMPOUNDS.
    Journal of medicinal chemistry, 1964, Volume: 7

    Topics: Amides; Anticonvulsants; Ataxia; Chemistry, Pharmaceutical; Mice; Pentylenetetrazole; Pharmacology;

1964
DIPHENYLHYDANTOIN METABOLISM, BLOOD LEVELS, AND TOXICITY.
    Archives of neurology, 1964, Volume: 11

    Topics: Ataxia; Blood Chemical Analysis; Drug Tolerance; Humans; Mental Disorders; Metabolism; Nystagmus, Pa

1964
DIPHENYLHYDANTOIN AND PHENOBARBITAL TOXICITY. THE ROLE OF LIVER DISEASE.
    Archives of neurology, 1964, Volume: 11

    Topics: Ataxia; Barbiturates; Blood Chemical Analysis; Chromatography; Drug Tolerance; Hepatitis; Hepatitis

1964
[TREATMENT OF EPILEPSY WITH 3-ETHOXYCARBO-5,5-DIPHENYLHYDANTOIN (P-6127), A NEW ANTICONVULSANT].
    No to shinkei = Brain and nerve, 1964, Volume: 16

    Topics: Anticonvulsants; Ataxia; Blood Chemical Analysis; Drug Therapy; Electroencephalography; Epilepsy; Ep

1964
NEUROLOGICAL SEQUELAE FOLLOWING DILANTIN OVERDOSE IN A PATIENT AND IN EXPERIMENTAL ANIMALS.
    Neurology, 1965, Volume: 15

    Topics: Adolescent; Ataxia; Biomedical Research; Cats; Chlordiazepoxide; Drug Therapy; Epilepsy; Humans; Neu

1965
SYNDROME OF GINGIVAL HYPERPLASIA, HIRSUTISM, AND CONVULSIONS; DILANTIN INTOXICATION WITHOUT DILANTIN.
    The Journal of pediatrics, 1965, Volume: 67

    Topics: Ataxia; Brain Diseases; Child; Chlorpheniramine; Diagnosis, Differential; Diencephalon; Drug Therapy

1965
Acute colchicine intoxication in a child: a case report.
    Pediatric emergency care, 2007, Volume: 23, Issue:5

    Topics: Acute Disease; Alopecia; Ataxia; Blood Transfusion; Case Management; Child, Preschool; Colchicine; C

2007
[Acute cerebellar ataxia associated with infectious mononucleosis].
    Nordisk medicin, 1967, Feb-02, Volume: 77, Issue:5

    Topics: Adolescent; Adult; Ataxia; Blood Cell Count; Cerebellar Diseases; Child, Preschool; Encephalitis; Hu

1967
Studies on Dilantin intoxication. I. Ultrastructural analogies with the lipoidoses.
    Neurology, 1967, Volume: 17, Issue:5

    Topics: Animals; Ataxia; Cerebellar Cortex; Coma; Cytoplasmic Granules; Lipidoses; Male; Microscopy, Electro

1967
Phenytoin (Dilantin) intoxication.
    Acta neurologica Scandinavica, 1967, Volume: 43, Issue:4

    Topics: Adolescent; Adult; Aged; Anorexia Nervosa; Ataxia; Child; Epilepsy; Female; Humans; Male; Mental Dis

1967
Downbeat nystagmus with phenytoin.
    Journal of clinical neuro-ophthalmology, 1982, Volume: 2, Issue:3

    Topics: Adult; Ataxia; Central Nervous System Diseases; Female; Humans; Male; Middle Aged; Nystagmus, Pathol

1982
Interaction of amiodarone and diphenylhydantoin.
    The American journal of cardiology, 1984, Nov-01, Volume: 54, Issue:8

    Topics: Aged; Amiodarone; Ataxia; Benzofurans; Drug Interactions; Humans; Male; Myocardial Infarction; Pheny

1984
Paroxysmal limb hemiataxia with crossed facial paresthesias in multiple sclerosis.
    JAMA, 1983, Nov-25, Volume: 250, Issue:20

    Topics: Adult; Ataxia; Carbamazepine; Face; Humans; Male; Multiple Sclerosis; Paresthesia; Phenytoin; Thromb

1983
Drug interactions on an alcohol unit.
    Virginia medical, 1982, Volume: 109, Issue:4

    Topics: Adult; Alcoholism; Ataxia; Diagnosis, Differential; Drug Interactions; Epilepsy; Humans; Male; Oxaze

1982
[Pharmacological studies on the functional development of the central nervous system in first generation rats born to phenytoin-treated mothers (author's transl)].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1982, Volume: 79, Issue:1

    Topics: Animals; Animals, Newborn; Ataxia; Birth Rate; Brain; Catalepsy; Diazepam; Eye; Feeding Behavior; Fe

1982
Phenothiazine-induced phenytoin intoxication.
    Annals of internal medicine, 1980, Volume: 93, Issue:1

    Topics: Adult; Aged; Ataxia; Drug Interactions; Dysarthria; Female; Humans; Male; Nystagmus, Pathologic; Phe

1980
Control of late postoperative ventricular arrhythmias with phenytoin in young patients.
    The American journal of cardiology, 1980, Volume: 46, Issue:2

    Topics: Adolescent; Adult; Arrhythmias, Cardiac; Ataxia; Child; Dose-Response Relationship, Drug; Electrocar

1980
Phenytoin elimination kinetics in two children with drug intoxication.
    European journal of pediatrics, 1980, Volume: 135, Issue:1

    Topics: Ataxia; Child; Female; Humans; Kinetics; Nystagmus, Pathologic; Phenytoin

1980
Ataxia in institutionalized patients with epilepsy.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1994, Volume: 21, Issue:3

    Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Anticonvulsants; Ataxia; Cerebellar Ataxia; Epilepsy;

1994
Phenytoin toxicity from smoking crack cocaine adulterated with phenytoin.
    Annals of emergency medicine, 1993, Volume: 22, Issue:9

    Topics: Adult; Ataxia; Charcoal; Crack Cocaine; Drug Contamination; Gastric Lavage; Humans; Male; Middle Age

1993
Images in clinical medicine. Gingival hyperplasia induced by phenytoin.
    The New England journal of medicine, 2000, Feb-03, Volume: 342, Issue:5

    Topics: Adolescent; Anticonvulsants; Ataxia; Epilepsy, Tonic-Clonic; Gingiva; Gingival Hyperplasia; Humans;

2000
Phenytoin intoxication induced by fluvoxamine.
    Therapeutic drug monitoring, 2001, Volume: 23, Issue:1

    Topics: Alleles; Anticonvulsants; Antidepressive Agents, Second-Generation; Aryl Hydrocarbon Hydroxylases; A

2001
Index of suspicion.
    Pediatrics in review, 2002, Volume: 23, Issue:7

    Topics: Adolescent; Anticonvulsants; Ataxia; Cellulitis; Child; Child, Preschool; Creatinine; Diagnosis, Dif

2002
Spasticity due to phenytoin toxicity.
    The Medical journal of Australia, 1979, Mar-10, Volume: 1, Issue:5

    Topics: Adult; Ataxia; Epilepsy, Tonic-Clonic; Humans; Male; Muscle Spasticity; Phenytoin; Reflex, Abnormal

1979
[Neurologic complications following medical treatment of epileptic patients].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1979, Volume: 79, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Ataxia; Benzodiazepines; Consciousness Disorders; Dysarthria; Ey

1979
Comparative trial of valproate sodium and clonazepam in chronic epilepsy.
    Archives of neurology, 1979, Volume: 36, Issue:5

    Topics: Adult; Ataxia; Benzodiazepinones; Chronic Disease; Clonazepam; Drug Therapy, Combination; Epilepsy;

1979
[Phenytoin intoxication and serum level].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1978, Volume: 30, Issue:7

    Topics: Adolescent; Adult; Aged; Ataxia; Athetosis; Attention; Child; Child, Preschool; Chorea; Dose-Respons

1978
[Severe cerebellar lesions caused by diphenylhydantoin--a contribution to the problem of hydantoin poisoning].
    Zeitschrift fur arztliche Fortbildung, 1978, Oct-01, Volume: 72, Issue:19

    Topics: Adolescent; Ataxia; Dietary Proteins; Dysarthria; Encephalitis; Epilepsy; Female; Humans; Nystagmus,

1978
[Brain stem seizures with circumscrbed elementary symptoms].
    Der Nervenarzt, 1976, Volume: 47, Issue:9

    Topics: Adult; Amitriptyline; Ataxia; Brain Neoplasms; Brain Stem; Carbamazepine; Epilepsy; Female; Humans;

1976
Familial poliodystrophy, mitochondrial myopathy, and lactate acidemia.
    Neurology, 1975, Volume: 25, Issue:7

    Topics: Adolescent; Ataxia; Cerebral Cortex; Child; Child, Preschool; Diazepam; Diffuse Cerebral Sclerosis o

1975
Anticonvulsant drug blood levels.
    JAMA, 1975, Apr-07, Volume: 232, Issue:1

    Topics: Anticonvulsants; Ataxia; Diplopia; Drug Therapy, Combination; Epilepsy; Humans; Nystagmus, Pathologi

1975
Deteriorating epilepsies: severely deteriorated cases.
    The Japanese journal of psychiatry and neurology, 1990, Volume: 44, Issue:2

    Topics: Adult; Anticonvulsants; Ataxia; Brain Damage, Chronic; Diagnosis, Differential; Drug Therapy, Combin

1990
Convulsant action of diphenylhydantoin overdose in young rats.
    Activitas nervosa superior, 1987, Volume: 29, Issue:1

    Topics: Animals; Animals, Newborn; Ataxia; Disease Susceptibility; Dose-Response Relationship, Drug; Male; P

1987
Generic substitution resulting in toxicity.
    Pennsylvania medicine, 1985, Volume: 88, Issue:12

    Topics: Aged; Ataxia; Biological Availability; Female; Humans; Phenytoin; Therapeutic Equivalency

1985
[Unfavorable and problematic drug combinations. IV].
    Der Internist, 1970, Volume: 11, Issue:11

    Topics: Amphetamine; Ataxia; Bone Marrow; Cerebral Hemorrhage; Depression, Chemical; Dicumarol; Dihydroxyphe

1970
Errors in phenytoin dosage.
    Lancet (London, England), 1973, Aug-04, Volume: 2, Issue:7823

    Topics: Ataxia; Child; Child, Preschool; Epilepsy; Female; Headache; Humans; Male; Medication Errors; Phenyt

1973
[Diphenylhydantoin in children. Clinico-pharmacological studies].
    Deutsche medizinische Wochenschrift (1946), 1973, Jul-20, Volume: 98, Issue:29

    Topics: Adolescent; Alkaline Phosphatase; Ataxia; Body Weight; Calcium; Child; Child, Preschool; Diplopia; D

1973
Choreo-athetosis and encephalopathy induced by phenytoin.
    British medical journal, 1974, Apr-27, Volume: 2, Issue:5912

    Topics: Adolescent; Adult; Ataxia; Athetosis; Carbamazepine; Chorea; Diplopia; Electroencephalography; Epile

1974
Anticonvulsant effect of diphenylhydantoin relative to plasma levels. A prospective three-year study in ambulant patients with generalized epileptic seizures.
    Archives of neurology, 1974, Volume: 31, Issue:5

    Topics: Adolescent; Adult; Aged; Ambulatory Care; Ataxia; Chromatography, Gas; Epilepsy; Epilepsy, Tonic-Clo

1974
Side effects of clonazepam therapy.
    Proceedings of the Australian Association of Neurologists, 1974, Volume: 11

    Topics: Adolescent; Adult; Aggression; Ataxia; Benzodiazepinones; Clonazepam; Drug Interactions; Epilepsy; E

1974
An adult form of acanthocytosis.
    Transactions of the American Neurological Association, 1967, Volume: 92

    Topics: Abetalipoproteinemia; Adult; Ataxia; Diazepam; Female; Haloperidol; Humans; Huntington Disease; Hydr

1967
The intracerebral effects of noradrenaline and its modification by drugs in the mouse.
    The Journal of pharmacy and pharmacology, 1966, Volume: 18, Issue:9

    Topics: Amitriptyline; Animals; Antidepressive Agents; Ataxia; Atropine; Body Temperature; Brain; Central Ne

1966
"Dilatin" overdosage.
    The Medical journal of Australia, 1968, Oct-12, Volume: 2, Issue:15

    Topics: Anticonvulsants; Ataxia; Brain Neoplasms; Carbamazepine; Diagnosis, Differential; Dibenzazepines; Ep

1968
Diphenylhydantoin.
    The Medical letter on drugs and therapeutics, 1971, Jun-11, Volume: 13, Issue:12

    Topics: Affective Symptoms; Arrhythmias, Cardiac; Ataxia; Carbamazepine; Central Nervous System Diseases; Ch

1971
Diphenylhydantoin-induced asterixis. A clinical study.
    JAMA, 1974, Jul-29, Volume: 229, Issue:5

    Topics: Ataxia; Electroencephalography; Electromyography; Epilepsy; Female; Humans; Male; Middle Aged; Nysta

1974
Choreoathetosis and diphenylhydantoin intoxication.
    JAMA, 1974, Nov-25, Volume: 230, Issue:8

    Topics: Adolescent; Adult; Ataxia; Athetosis; Chorea; Diplopia; Female; Humans; Male; Nystagmus, Pathologic;

1974
Serum concentrations of free diphenylhydantoin and their relationship to clinical intoxication.
    Epilepsia, 1973, Volume: 14, Issue:2

    Topics: Ataxia; Blood Proteins; Chromatography, Gas; Humans; Methods; Nystagmus, Pathologic; Phenytoin; Prot

1973
Primidone, diphenylhydantoin and phenobarbital. Aspects of acute and chronic toxicity.
    Neurology, 1973, Volume: 23, Issue:2

    Topics: Ataxia; Chromatography, Gas; Drug Tolerance; Epilepsy; Humans; Nystagmus, Pathologic; Phenobarbital;

1973
Letter: Permanent brain damage after lithium intoxication.
    British medical journal, 1973, Dec-15, Volume: 4, Issue:5893

    Topics: Adult; Ataxia; Brain Damage, Chronic; Diuresis; Female; Humans; Lithium; Middle Aged; Nystagmus, Pat

1973
Movement disorder as a manifestation of diphenylhydantoin intoxication.
    Neurology, 1974, Volume: 24, Issue:1

    Topics: Adult; Ataxia; Athetosis; Chorea; Epilepsy; Female; Humans; Middle Aged; Nystagmus, Pathologic; Phen

1974
Phenytoin intoxication in childhood due to incorrect prescribing, dispensing and administration of suspensions.
    The Medical journal of Australia, 1969, Aug-09, Volume: 2, Issue:6

    Topics: Age Factors; Ataxia; Child; Child, Preschool; Drug Prescriptions; Epilepsy, Tonic-Clonic; Female; Hu

1969
Diphenylhydantoin (Dilantin) neurotoxicity--a deceptive syndrome.
    Journal of the American Geriatrics Society, 1969, Volume: 17, Issue:11

    Topics: Aged; Ataxia; Capsules; Diagnosis, Differential; Epilepsy, Tonic-Clonic; Humans; Male; Medication Er

1969
The ineffectiveness of diphenylhydantoin in preventing febrile convulsions in the age of greatest risk, under three years.
    Epilepsia, 1971, Volume: 12, Issue:1

    Topics: Age Factors; Ataxia; Attention; Child, Preschool; Epilepsy, Absence; Fever; Humans; Infant; Phenytoi

1971
Intoxication with 5,5-diphenylhydantoin (Dilantin): clinical features, blood levels, urinary metabolites, and metabolic changes in a child.
    The Journal of pediatrics, 1972, Volume: 80, Issue:4

    Topics: Ataxia; Child, Preschool; Glucuronates; Half-Life; Humans; Hyperglycemia; Insulin; Male; Movement Di

1972
Adverse effects of hydantoins.
    The Medical journal of Australia, 1971, Aug-14, Volume: 2, Issue:7

    Topics: Ataxia; Drug Hypersensitivity; Folic Acid; Humans; Neurologic Manifestations; Phenytoin; Skin Manife

1971
Methylphenidate and the hyperkinetic state.
    Diseases of the nervous system, 1971, Volume: 32, Issue:10

    Topics: Ataxia; Child; Drug Synergism; Feeding and Eating Disorders; Humans; Hyperkinesis; Hypertension; Met

1971
Delayed phenytoin idiosyncrasy.
    British medical journal, 1969, Nov-22, Volume: 4, Issue:5681

    Topics: Ataxia; Epilepsy; Humans; Nystagmus, Pathologic; Phenytoin

1969
Intolerance to diphenylhydantoin in five cases of Vogt-Spielmeyer disease.
    Journal of mental deficiency research, 1969, Volume: 13, Issue:4

    Topics: Ataxia; Brain; Humans; L-Lactate Dehydrogenase; Lipidoses; Phenobarbital; Phenytoin; Primidone; Seiz

1969
Digoxin-phenytoin interaction.
    British medical journal, 1970, Apr-04, Volume: 2, Issue:5700

    Topics: Ataxia; Cerebellar Diseases; Coma; Digoxin; Humans; Male; Middle Aged; Phenytoin

1970
Diphenylhydantoin intoxication attendant to slow inactivation of isoniazid.
    Neurology, 1970, Volume: 20, Issue:7

    Topics: Animals; Ataxia; Cats; Drug Tolerance; Epilepsy; Genetics, Medical; Humans; Isoniazid; Nystagmus, Pa

1970
[Therapy of epilepsy in mentally retarded children. Neuropsychiatric disorders caused by diphenylhydantoin].
    Therapeutische Umschau. Revue therapeutique, 1970, Volume: 27, Issue:7

    Topics: Adolescent; Affective Symptoms; Ataxia; Child; Epilepsy; Humans; Intellectual Disability; Male; Musc

1970
Brain folate and diphenylhydantoin (DPH) concentrations in ataxic cats receiving DPH.
    Transactions of the American Neurological Association, 1970, Volume: 95

    Topics: Animals; Ataxia; Brain; Cats; Folic Acid; Liver; Phenytoin

1970
The neurologic hazards of diphenylhydantoin in childhood.
    The Journal of pediatrics, 1968, Volume: 73, Issue:5

    Topics: Adolescent; Ataxia; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Neurologic Mani

1968
Management of epilepsy with diphenylhydantoin sodium. Dosage regulation for problem patients.
    JAMA, 1968, Mar-11, Volume: 203, Issue:11

    Topics: Adult; Antitubercular Agents; Ataxia; Drug Tolerance; Epilepsy; Hospitalization; Humans; Nystagmus,

1968
2,3-benzoxazines. IX. Synthesis and central nervous system depressant activity of some 3,6- and 3,7-disubstituted 1H-3,4-dihydro-2,3-benzoxazines.
    Journal of medicinal chemistry, 1969, Volume: 12, Issue:2

    Topics: Analgesia; Animals; Aspirin; Ataxia; Barbiturates; Central Nervous System; Chlordiazepoxide; Chlorpr

1969
Use of diphenylhydantoin in epilepsy treatment.
    Developmental medicine and child neurology, 1969, Volume: 11, Issue:1

    Topics: Ataxia; Chemical and Drug Induced Liver Injury; Epilepsy; Humans; Necrosis; Nervous System Diseases;

1969
Methylphenidate interaction with both anticonvulsants and ethyl biscoumacetate.
    JAMA, 1969, Mar-17, Volume: 207, Issue:11

    Topics: Adult; Anticonvulsants; Ataxia; Brain Diseases; Child, Preschool; Depression, Chemical; Ethyl Biscou

1969
Depression of prahydroxylation of diphenylhydantoin by antituberculosis chemotherapy.
    Neurology, 1966, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Aged; Aminosalicylic Acids; Anticonvulsants; Ataxia; Cycloserine; Drug Incompatib

1966