phenytoin has been researched along with Astrocytoma, Grade IV in 16 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Celecoxib (400) mg was administered orally twice a day until tumor progression or dose-limiting toxicity." | 6.73 | Effect of phenytoin on celecoxib pharmacokinetics in patients with glioblastoma. ( Batchelor, T; Desideri, S; Grossman, SA; Hammour, T; Lesser, G; Olson, J; Peereboom, D; Supko, JG; Ye, X, 2008) |
| " The pooled data were analyzed using population pharmacokinetic (POP-PK) methods." | 5.33 | Population pharmacokinetics of motexafin gadolinium in adults with brain metastases or glioblastoma multiforme. ( Boswell, GW; Ford, JM; Hutcheson, SJ; Miles, DR; Phan, SC; Renschler, MF; Smith, JA, 2005) |
| "A 56-year-old man with a small glioblastoma multiforme in the right parasagittal region developed orofacial dyskinesia and slight writhing movement of his hands during treatment with phenytoin and phenobarbitone." | 3.67 | Phenytoin-induced orofacial dyskinesia. A case report. ( Nakanishi, T; Ozaki, Y; Yamada, S; Yoshida, M, 1985) |
| "Celecoxib (400) mg was administered orally twice a day until tumor progression or dose-limiting toxicity." | 2.73 | Effect of phenytoin on celecoxib pharmacokinetics in patients with glioblastoma. ( Batchelor, T; Desideri, S; Grossman, SA; Hammour, T; Lesser, G; Olson, J; Peereboom, D; Supko, JG; Ye, X, 2008) |
| " Newly diagnosed patients with high-grade glioma received IFN-alpha2a at a dosage of 3 to 6 million IU s." | 2.70 | Interferon-alpha2a and 13-cis-retinoic acid with radiation treatment for high-grade glioma. ( Barth, NM; Church, CK; DePriest, C; Dillman, RO; Kharkar, BR; Mahdavi, K; Poor, MM; Shea, WM; Tai, DF, 2001) |
| " The pooled data were analyzed using population pharmacokinetic (POP-PK) methods." | 1.33 | Population pharmacokinetics of motexafin gadolinium in adults with brain metastases or glioblastoma multiforme. ( Boswell, GW; Ford, JM; Hutcheson, SJ; Miles, DR; Phan, SC; Renschler, MF; Smith, JA, 2005) |
| "A 35-year-old man presented with partial seizures 10 years after resection of a left-sided glioblastoma multiforme." | 1.30 | Transient MRI enhancement in a patient with seizures and previously resected glioma: use of MRS. ( Cecil, KM; Hackney, DB; Lenkinski, RE; Pruitt, AA; Quan, D, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lawrence, JE | 1 |
| Steele, CJ | 1 |
| Rovin, RA | 1 |
| Belton, RJ | 1 |
| Winn, RJ | 1 |
| Liang, S | 1 |
| Zhang, J | 1 |
| Zhang, S | 1 |
| Fu, X | 1 |
| Guthrie, GD | 1 |
| Eljamel, S | 1 |
| Camartin, C | 1 |
| Reinhart, WH | 1 |
| Kuhn, M | 1 |
| Miles, DR | 1 |
| Smith, JA | 1 |
| Phan, SC | 1 |
| Hutcheson, SJ | 1 |
| Renschler, MF | 1 |
| Ford, JM | 1 |
| Boswell, GW | 1 |
| Altundag, O | 1 |
| Altundag, K | 1 |
| Boruban, C | 1 |
| Altundag, MB | 1 |
| Turen, S | 1 |
| Grossman, SA | 1 |
| Olson, J | 1 |
| Batchelor, T | 1 |
| Peereboom, D | 1 |
| Lesser, G | 1 |
| Desideri, S | 1 |
| Ye, X | 1 |
| Hammour, T | 1 |
| Supko, JG | 1 |
| Sayk, J | 1 |
| Kmietzyk, HJ | 1 |
| Landolt, H | 1 |
| Langemann, H | 1 |
| Probst, A | 1 |
| Gratzl, O | 1 |
| Janinis, J | 1 |
| Panagos, G | 1 |
| Panousaki, A | 1 |
| Skarlos, D | 1 |
| Athanasiou, E | 1 |
| Karpasitis, N | 1 |
| Pirounaki, M | 1 |
| Lukovits, TG | 1 |
| Fadul, CE | 1 |
| Pipas, JM | 1 |
| Williamson, PD | 1 |
| Quan, D | 1 |
| Hackney, DB | 1 |
| Pruitt, AA | 1 |
| Lenkinski, RE | 1 |
| Cecil, KM | 1 |
| Dillman, RO | 1 |
| Shea, WM | 1 |
| Tai, DF | 1 |
| Mahdavi, K | 1 |
| Barth, NM | 1 |
| Kharkar, BR | 1 |
| Poor, MM | 1 |
| Church, CK | 1 |
| DePriest, C | 1 |
| Vincent, FM | 1 |
| Ghosh, C | 1 |
| Lazarus, HM | 1 |
| Hewlett, JS | 1 |
| Creger, RJ | 1 |
| Yoshida, M | 1 |
| Yamada, S | 1 |
| Ozaki, Y | 1 |
| Nakanishi, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Prospective Trial for Validation of the Role of Levetiracetam as a Sensitizer of Temozolomide in the Treatment of Newly Diagnosed Glioblastoma Patients[NCT02815410] | Phase 2 | 73 participants (Anticipated) | Interventional | 2016-07-31 | Not yet recruiting | ||
| A Pharmacokinetic Study of the Interaction Between Celecoxib and Anticonvulsant Drugs in Patients With Newly Diagnosed Glioblastoma Multiforme Undergoing Radiation Therapy[NCT00068770] | Phase 2 | 35 participants (Actual) | Interventional | 2003-10-31 | Terminated (stopped due to EORTC trail showed TMZ & RT conferred significant survivial in this population) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
subjects will take one dose of celecoxib and will then have 6 hours of blood draws, day 2 subject will take 2 doses of celecoxib 8 hours apart with 2 additional blood samples, one hour apart. Subject, will continue to take 2 doses of celecoxib for 6 weeks, with a sample (PK) drawn every week prior to the first dose of the week. Comparison of Cmax of Celecoxib is reported (NCT00068770)
Timeframe: First dose of celecoxib through completion of radiation, 6 weeks.
| Intervention | (ng/ml) (Geometric Mean) |
|---|---|
| nonp450 | 1752 |
| p450 | 1813 |
duration of survival when celecoxib is administered concurrently with radiation in pts with newly diagnosed glioblastoma multiforme (NCT00068770)
Timeframe: date pt started treatment to date pt last known alive
| Intervention | months (Mean) |
|---|---|
| p450 ( +EIASD) | 11.5 |
| nonp450 (-EIASD) | 16 |
1 review available for phenytoin and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Impact of particular antiepileptic drugs on the survival of patients with glioblastoma multiforme.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain Neoplasms; Carbamazepine; Cohort Studies; Female; Gl | 2013 |
3 trials available for phenytoin and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Effect of phenytoin on celecoxib pharmacokinetics in patients with glioblastoma.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Antineoplastic Agents; Area Under Curve; Brain Neoplasms; | 2008 |
Interferon-alpha2a and 13-cis-retinoic acid with radiation treatment for high-grade glioma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Adjuvant; Comb | 2001 |
Fluctuation of serum phenytoin concentrations during autologous bone marrow transplant for primary central nervous system tumors.
Topics: Adult; Anticonvulsants; Astrocytoma; Bone Marrow Transplantation; Brain Neoplasms; Carbamazepine; Fe | 1992 |
12 other studies available for phenytoin and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Dexamethasone alone and in combination with desipramine, phenytoin, valproic acid or levetiracetam interferes with 5-ALA-mediated PpIX production and cellular retention in glioblastoma cells.
Topics: Aminolevulinic Acid; Anti-Inflammatory Agents; Anticonvulsants; Desipramine; Dexamethasone; Drug The | 2016 |
Epilepsy in Adults with Supratentorial Glioblastoma: Incidence and Influence Factors and Prophylaxis in 184 Patients.
Topics: Adult; Aged; Anticonvulsants; Craniotomy; Epilepsy; Female; Frontal Lobe; Glioblastoma; Humans; Male | 2016 |
[Brain irradiation and phenytoin: a dangerous liaison?].
Topics: Adenocarcinoma; Adult; Aged; Anticonvulsants; Brain Neoplasms; Drug Eruptions; Female; Glioblastoma; | 2003 |
Population pharmacokinetics of motexafin gadolinium in adults with brain metastases or glioblastoma multiforme.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alkaline Phosphatase; Anticonvulsants; Antineoplastic A | 2005 |
Phenytoin may increase the efficacy of temozolomide by methylating DNA-repair enzyme, O6-methylguanine-DNA methyltransferase in patients with glioblastoma.
Topics: Dacarbazine; DNA Repair; Glioblastoma; Humans; Methylation; O(6)-Methylguanine-DNA Methyltransferase | 2005 |
[Survival period of patients with gliomata or glioblastomata under anti-convulsive therapy (author's transl)].
Topics: Adult; Brain Neoplasms; Epilepsy; Female; Glioblastoma; Glioma; Humans; Male; Phenytoin; Prognosis | 1981 |
Levels of water-soluble antioxidants in astrocytoma and in adjacent tumor-free tissue.
Topics: Adult; Aged; Antioxidants; Artifacts; Ascorbic Acid; Astrocytoma; Biopsy; Brain Chemistry; Brain Ede | 1994 |
Stevens-Johnson syndrome and epidermal necrolysis after administration of sodium phenytoin with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cranial Irradiation; Glioblastoma; Humans; Male; Middle Aged; Phenytoin; Ste | 1993 |
Nonconvulsive status epilepticus after intravenous contrast medium administration.
Topics: Brain Neoplasms; Contrast Media; Diatrizoate Meglumine; Electroencephalography; Glioblastoma; Humans | 1996 |
Transient MRI enhancement in a patient with seizures and previously resected glioma: use of MRS.
Topics: Adult; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Carmustine; Combi | 1999 |
Phenytoin/dexamethasone interaction.
Topics: Brain Neoplasms; Dexamethasone; Drug Interactions; Glioblastoma; Humans; Methylprednisolone; Phenyto | 1978 |
Phenytoin-induced orofacial dyskinesia. A case report.
Topics: Brain Neoplasms; Cerebral Cortex; Dyskinesia, Drug-Induced; Electroencephalography; Face; Glioblasto | 1985 |