phenytoin has been researched along with Altitude Sickness in 3 studies
Altitude Sickness: Multiple symptoms associated with reduced oxygen at high ALTITUDE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the effect of plateau hypoxia on the concentration of P-glycoprotein (P-gp) substrate phenytoin, Wistar rats are randomly divided into the control group and the hypoxic group, including P-gp inhibited groups respectively." | 7.96 | Enhanced P-glycoprotein expression under high-altitude hypoxia contributes to increased phenytoin levels and reduced clearance in rats. ( Wang, R; Zhang, J; Zhang, M, 2020) |
| "To study the effect of plateau hypoxia on the concentration of P-glycoprotein (P-gp) substrate phenytoin, Wistar rats are randomly divided into the control group and the hypoxic group, including P-gp inhibited groups respectively." | 3.96 | Enhanced P-glycoprotein expression under high-altitude hypoxia contributes to increased phenytoin levels and reduced clearance in rats. ( Wang, R; Zhang, J; Zhang, M, 2020) |
| "Phenytoin sodium was evaluated for its effect on the development and intensity of acute mountain sickness (AMS) because of its ability to reduce intracellular Na+ concentrations in brain and thereby minimize any tendency to increase cellular volume, a hypothetical cause of AMS." | 2.65 | Phenytoin: ineffective against acute mountain sickness. ( Burse, RL; Landowne, M; Maher, JT; Young, AJ, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, J | 2 |
| Zhang, M | 1 |
| Wang, R | 1 |
| Burse, RL | 1 |
| Landowne, M | 1 |
| Young, AJ | 1 |
| Maher, JT | 1 |
| Wohns, RN | 1 |
| Colpitts, M | 1 |
| Clement, T | 1 |
| Karuza, A | 1 |
| Blackett, WB | 1 |
| Foutch, R | 1 |
| Larson, E | 1 |
2 trials available for phenytoin and Altitude Sickness
| Article | Year |
|---|---|
Phenytoin: ineffective against acute mountain sickness.
Topics: Acute Disease; Adult; Aerospace Medicine; Altitude Sickness; Clinical Trials as Topic; Double-Blind | 1982 |
Phenytoin and acute mountain sickness on Mount Everest.
Topics: Acute Disease; Adult; Altitude; Altitude Sickness; Clinical Trials as Topic; Double-Blind Method; Hu | 1986 |
1 other study available for phenytoin and Altitude Sickness
| Article | Year |
|---|---|
Enhanced P-glycoprotein expression under high-altitude hypoxia contributes to increased phenytoin levels and reduced clearance in rats.
Topics: Altitude Sickness; Animals; ATP Binding Cassette Transporter, Subfamily B; Blood-Brain Barrier; Brai | 2020 |