phenytoin has been researched along with Allergic Encephalomyelitis in 8 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " To determine whether phenytoin has a protective effect on axons in a neuroinflammatory model, we studied the effect of phenytoin on axonal degeneration in the optic nerve in MOG-induced experimental allergic encephalomyelitis (EAE)." | 7.71 | Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis. ( Black, JA; Lo, AC; Waxman, SG, 2002) |
| " In this study, we asked whether phenytoin, which is known to block sodium channels, can protect spinal cord axons from degeneration in mice with experimental allergic encephalomyelitis (EAE), which display substantial axonal degeneration and clinical paralysis." | 3.72 | Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivo. ( Black, JA; Lo, AC; Saab, CY; Waxman, SG, 2003) |
| " To determine whether phenytoin has a protective effect on axons in a neuroinflammatory model, we studied the effect of phenytoin on axonal degeneration in the optic nerve in MOG-induced experimental allergic encephalomyelitis (EAE)." | 3.71 | Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis. ( Black, JA; Lo, AC; Waxman, SG, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, S | 4 |
| Zwinger, P | 1 |
| Black, JA | 7 |
| Waxman, SG | 7 |
| Hashiba, N | 1 |
| Nagayama, S | 1 |
| Araya, SI | 1 |
| Inada, H | 1 |
| Sonobe, Y | 1 |
| Suzumura, A | 1 |
| Matsui, M | 1 |
| Lo, AC | 3 |
| Saab, CY | 2 |
| Craner, MJ | 1 |
| Damarjian, TG | 1 |
| Hains, BC | 2 |
| Newcombe, J | 1 |
| Cuzner, ML | 1 |
| Carrithers, M | 1 |
| Carrithers, LM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Cohort Study of Association Between Steady State Phenytoin Treatment and Better Clinical Parameters of Glaucoma[NCT00739154] | 200 participants (Anticipated) | Observational | 2008-11-30 | Not yet recruiting | |||
| OxCarbazepine as a Neuroprotective Agent in MS: A Phase 2a Trial[NCT02104661] | Phase 2 | 30 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for phenytoin and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Phenytoin protects central axons in experimental autoimmune encephalomyelitis.
Topics: Animals; Axons; Central Nervous System; Disease Models, Animal; Encephalomyelitis, Autoimmune, Exper | 2008 |
7 other studies available for phenytoin and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Tapered withdrawal of phenytoin removes protective effect in EAE without inflammatory rebound and mortality.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Encephalomyelitis, Autoimmune, Experi | 2014 |
Phenytoin at optimum doses ameliorates experimental autoimmune encephalomyelitis via modulation of immunoregulatory cells.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Immun | 2011 |
Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis.
Topics: Animals; Axons; Cell Death; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Imm | 2002 |
Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivo.
Topics: Animals; Axonal Transport; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Male | 2003 |
Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.
Topics: Animals; Axons; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gliosis | 2005 |
Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE.
Topics: Action Potentials; Administration, Oral; Animals; Axons; Cell Count; Cervical Vertebrae; Chronic Dis | 2006 |
Exacerbation of experimental autoimmune encephalomyelitis after withdrawal of phenytoin and carbamazepine.
Topics: Animals; Anticonvulsants; Antigens, CD; Axons; Carbamazepine; Cell Count; Disease Models, Animal; En | 2007 |