phenytoin has been researched along with Aging in 84 studies
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Phenytoin sodium (phenytoin) has a side effect of gingival hyperplasia and an effect on the autophagy progress." | 7.96 | Phenytoin sodium-ameliorated gingival fibroblast aging is associated with autophagy. ( Hu, X; Kang, Y; Tang, T; Wei, Z; Yang, R; Zha, G; Zhu, D; Zhu, L, 2020) |
| "Phenytoin (PHT) is widely used to treat epilepsy in elderly patients, but information on its pharmacokinetics in this population is limited." | 7.74 | Phenytoin half-life and clearance during maintenance therapy in adults and elderly patients with epilepsy. ( Ahn, JE; Birnbaum, AK; Brundage, RC; Cloyd, JC; Conway, JM; Leppik, IE; Marino, SE; Musib, LC; Ramsay, RE; Rarick, JO; White, JR, 2008) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 7.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| "Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug." | 7.67 | Bioavailability and pharmacokinetics of phenytoin during pregnancy. ( Chalk, JB; de Wytt, C; Eadie, MJ; Lander, CM; Livingstone, I; Smith, MT; Symoniw, P, 1984) |
| "Cataracts developed in two young adults who were receiving prolonged antiepileptic treatment with phenobarbital sodium and phenytoin sodium." | 7.66 | Presenile cataracts in phenytoin-treated epileptic patients. ( Bar, S; Feller, N; Savir, H, 1983) |
| "The phenytoin cells appear to be a unique phenotype." | 5.28 | Effect of cell donor age on the synthetic properties of fibroblasts obtained from phenytoin-induced gingival hyperplasia. ( Johnson, BD; Narayanan, AS; Page, RC; Pieters, HP, 1990) |
| "Phenytoin was administered as an i." | 5.27 | Aging and drug interactions. II. Effect of phenytoin and smoking on the oxidation of theophylline and cortisol in healthy men. ( Crowley, JJ; Cusack, BJ; Jue, SG; Koup, JR; Park, BK; Vestal, RE, 1988) |
| "Subjects were 85 men with localization-related epilepsy (25 on carbamazepine [CBZ], 25 on phenytoin [PHT], 25 on lamotrigine [LTG], and 10 untreated for at least 6 months [no AED]) and 25 controls." | 5.11 | Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy. ( Bromfield, EB; Drislane, FW; Dworetzky, BA; Farina, EL; Frye, CA; Herzog, AG; Pennell, PB; Schomer, DL, 2005) |
| "To determine whether biological maturation influences the kinetics of carbamazepine-serum protein binding, the carbamazepine free fraction (%) was investigated in the serum of 66 patients, ranging from 4 to 83 years, with epilepsy or trigeminal neuralgia, treated with carbamazepine alone or carbamazepine in combination with phenytoin, phenobarbital, and/or valproic acid, over a relatively long period." | 5.09 | Age-related alteration of carbamazepine-serum protein binding in man. ( Koyama, H; Mori, S; Nakajima, K; Sugioka, N; Uno, A, 1999) |
| " Phenytoin sodium (phenytoin) has a side effect of gingival hyperplasia and an effect on the autophagy progress." | 3.96 | Phenytoin sodium-ameliorated gingival fibroblast aging is associated with autophagy. ( Hu, X; Kang, Y; Tang, T; Wei, Z; Yang, R; Zha, G; Zhu, D; Zhu, L, 2020) |
| "Phenytoin (PHT) is widely used to treat epilepsy in elderly patients, but information on its pharmacokinetics in this population is limited." | 3.74 | Phenytoin half-life and clearance during maintenance therapy in adults and elderly patients with epilepsy. ( Ahn, JE; Birnbaum, AK; Brundage, RC; Cloyd, JC; Conway, JM; Leppik, IE; Marino, SE; Musib, LC; Ramsay, RE; Rarick, JO; White, JR, 2008) |
| "The anticonvulsant actions of lamotrigine and phenytoin against pentylenetetrazol-induced seizures were compared in laboratory rats during ontogenesis." | 3.68 | Anticonvulsant action of lamotrigine during ontogenesis in rats. ( Kubová, H; Mares, P; Stanková, L, 1992) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 3.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| "To examine whether a drug-metabolizing enzyme changes with normal aging, the S:R index of S-mephenytoin 4-hydroxylation was determined in 150, unmedicated elderly Americans (mean age 75." | 3.68 | S-mephenytoin 4-hydroxylation in older Americans. ( Altieri, LP; Kirshner, M; Perel, JM; Pollock, BG; Reynolds, CF; Yeager, AL, 1991) |
| "Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug." | 3.67 | Bioavailability and pharmacokinetics of phenytoin during pregnancy. ( Chalk, JB; de Wytt, C; Eadie, MJ; Lander, CM; Livingstone, I; Smith, MT; Symoniw, P, 1984) |
| "Cataracts developed in two young adults who were receiving prolonged antiepileptic treatment with phenobarbital sodium and phenytoin sodium." | 3.66 | Presenile cataracts in phenytoin-treated epileptic patients. ( Bar, S; Feller, N; Savir, H, 1983) |
| "The pharmacokinetic variability of moclobemide, a new short half-life reversible selective inhibitor of monoamine oxidase (MAO) was investigated through analysis of concentrations measured during early open clinical use." | 2.68 | Potential of concentration monitoring data for a short half-life drug: analysis of pharmacokinetic variability for moclobemide. ( Balant, LP; Balant-Gorgia, AE; Gex-Fabry, M, 1995) |
| "The relationship between a dose of phenytoin and the resultant serum concentration is difficult to predict, and numerous dosing methods have been developed to quantify the dose required to achieve a specific concentration." | 2.38 | An updated comparison of drug dosing methods. Part I: Phenytoin. ( Erdman, SM; Pryka, RD; Rodvold, KA, 1991) |
| " The absorption rate and fraction are very much dependent on the pharmaceutical preparation, and changes of brand may alter the plasma level of phenytoin in spite of unaltered dose." | 2.35 | Clinical pharmacokinetics of anticonvulsants. ( Dam, M; Hvidberg, EF, 1976) |
| "We utilized a middle cerebral artery occlusion model and examined seizure activity and brain injury using combined behavioral and electroencephalographic monitoring and histological assessments." | 1.42 | Modeling early-onset post-ischemic seizures in aging mice. ( Aljarallah, S; Eubanks, JH; Gao, X; Huang, Y; McDonald, R; Patel, N; Peng, J; Wang, J; Wu, C; Zhang, L, 2015) |
| "With either etiology, seizures are a poor prognostic factor." | 1.42 | Early-Onset Convulsive Seizures Induced by Brain Hypoxia-Ischemia in Aging Mice: Effects of Anticonvulsive Treatments. ( Aljarallah, S; Eubanks, JH; Gao, X; Huang, Y; McDonald, R; Patel, N; Peng, J; Wang, J; Wu, C; Zhang, L, 2015) |
| "Although both POPPK and physiologically based pharmacokinetic (PBPK) models can account for age and other covariates within a paediatric population, they generally do not account for real-time growth and maturation of the individuals through the time course of drug exposure; this may be significant in prolonged neonatal studies." | 1.40 | Changes in individual drug-independent system parameters during virtual paediatric pharmacokinetic trials: introducing time-varying physiology into a paediatric PBPK model. ( Abduljalil, K; Jamei, M; Johnson, TN; Rostami-Hodjegan, A, 2014) |
| "Epilepsy was confirmed in 58 cases." | 1.37 | [Epilepsy in elderly]. ( Kotov, AS; Rudakova, IG, 2011) |
| " The elimination half-life for the entire patient population was approximately twofold longer than the value reported in the product labeling (40-50 h vs 22 h)." | 1.34 | Factors affecting antiepileptic drug pharmacokinetics in community-dwelling elderly. ( Birnbaum, AK; Cloyd, JC; Marino, S, 2007) |
| " This finding indicates the need for further investigation into the effects of phenytoin on brain regions other than the cerebellum, as intellectual deterioration may be related to chronic use of this drug." | 1.28 | Lipopigment in rat hippocampal and Purkinje neurones after chronic phenytoin administration. ( Dowson, JH; James, NT; Wilton-Cox, H, 1992) |
| "We reviewed our data from 122 records of patients taking phenytoin for the treatment of various types of epilepsy and selected 15 (age range 10-43 years old) who were on phenytoin alone to calculate Michaelis-Menten pharmacokinetic parameters." | 1.28 | Michaelis-Menten pharmacokinetics of phenytoin in adult Malaysian patients. ( Ismail, R; Rahman, AF, 1990) |
| "The phenytoin cells appear to be a unique phenotype." | 1.28 | Effect of cell donor age on the synthetic properties of fibroblasts obtained from phenytoin-induced gingival hyperplasia. ( Johnson, BD; Narayanan, AS; Page, RC; Pieters, HP, 1990) |
| " These findings should therefore be considered when defining dosage regimens or interpreting serum drug concentrations." | 1.28 | Analysis of the factors influencing anti-epileptic drug concentrations--valproic acid. ( Aoyama, T; Higuchi, S; Hirata, K; Ieiri, I; Yamada, H, 1990) |
| "Five methods to predict phenytoin dosage have been compared in nine continuous care elderly patients." | 1.28 | Phenytoin dosage individualization--five methods compared in the elderly. ( Farquhar, DL; Hudson, SA; Smith, RG; Thompson, D, 1990) |
| "The Michaelis-Menten pharmacokinetic parameters Vmax and Km were calculated for 17 epileptic Saudi patients receiving phenytoin." | 1.28 | Phenytoin Michaelis-Menten pharmacokinetics in Saudi patients. ( el-Sayed, YM; Islam, SI, 1989) |
| "Relative bioavailability (RB) of two commercially available phenytoin preparations showed greater differences in absorption in children than in adults." | 1.27 | Relative bioavailability of two different phenytoin preparations. Evidence for an age dependency. ( Higashi, A; Ikeda, T; Matsuda, I; Matsukura, M, 1984) |
| "Phenobarbital was slowly eliminated from the plasma at all ages and there was no indication of p-hydroxylated metabolite formation." | 1.27 | Drug disposition and biotransformation in the developing beagle dog. ( D'Ver, AS; Ecobichon, DJ; Ehrhart, W, 1988) |
| " These observations suggest that dosage regimen adjustment of phenytoin based on the averaged Vmax in a given pediatric age group rather than the Km is recommended for a particular patient with inadequate therapeutic control of seizure or toxicity of this drug." | 1.26 | Apparent Michaelis-Menten kinetic parameters of phenytoin in pediatric patients. ( Chiba, K; Ishizaki, T; Minagawa, K; Miura, H, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 47 (55.95) | 18.7374 |
| 1990's | 19 (22.62) | 18.2507 |
| 2000's | 10 (11.90) | 29.6817 |
| 2010's | 6 (7.14) | 24.3611 |
| 2020's | 2 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Fox, J | 1 |
| Ajinkya, S | 1 |
| Lekoubou, A | 1 |
| Kang, Y | 1 |
| Yang, R | 1 |
| Wei, Z | 1 |
| Zhu, D | 1 |
| Tang, T | 1 |
| Zhu, L | 1 |
| Hu, X | 1 |
| Zha, G | 1 |
| Abduljalil, K | 1 |
| Jamei, M | 1 |
| Rostami-Hodjegan, A | 1 |
| Johnson, TN | 1 |
| Wu, C | 2 |
| Wang, J | 2 |
| Peng, J | 2 |
| Patel, N | 2 |
| Huang, Y | 2 |
| Gao, X | 2 |
| Aljarallah, S | 2 |
| Eubanks, JH | 2 |
| McDonald, R | 2 |
| Zhang, L | 2 |
| Ahn, JE | 1 |
| Cloyd, JC | 3 |
| Brundage, RC | 1 |
| Marino, SE | 1 |
| Conway, JM | 1 |
| Ramsay, RE | 1 |
| White, JR | 1 |
| Musib, LC | 1 |
| Rarick, JO | 1 |
| Birnbaum, AK | 2 |
| Leppik, IE | 2 |
| Fukuoka, N | 2 |
| Uno, J | 2 |
| Tsukamoto, T | 2 |
| Houchi, H | 1 |
| Kimura, M | 2 |
| Morita, S | 2 |
| Forcelli, PA | 1 |
| Gale, K | 1 |
| Kondratyev, A | 1 |
| Kotov, AS | 1 |
| Rudakova, IG | 1 |
| Abramov, JP | 1 |
| Tran, A | 1 |
| Shapiro, AM | 1 |
| Wells, PG | 1 |
| Perucca, E | 2 |
| Berlowitz, D | 1 |
| Birnbaum, A | 1 |
| Garrard, J | 1 |
| Hanlon, JT | 1 |
| Levy, RH | 1 |
| Pugh, MJ | 1 |
| Herzog, AG | 1 |
| Drislane, FW | 1 |
| Schomer, DL | 1 |
| Pennell, PB | 1 |
| Bromfield, EB | 1 |
| Dworetzky, BA | 1 |
| Farina, EL | 1 |
| Frye, CA | 1 |
| Carter, MD | 1 |
| Weaver, DF | 1 |
| Joudrey, HR | 1 |
| Carter, AO | 1 |
| Rockwood, K | 1 |
| Marino, S | 1 |
| Bukowskyj, M | 1 |
| Nakatsu, K | 1 |
| Munt, PW | 1 |
| Lander, CM | 1 |
| Smith, MT | 1 |
| Chalk, JB | 1 |
| de Wytt, C | 1 |
| Symoniw, P | 1 |
| Livingstone, I | 1 |
| Eadie, MJ | 2 |
| Keith, DA | 2 |
| Gundberg, CM | 1 |
| Japour, A | 1 |
| Aronoff, J | 1 |
| Alvarez, N | 1 |
| Gallop, PM | 1 |
| Kitani, K | 1 |
| Masuda, Y | 1 |
| Sato, Y | 1 |
| Kanai, S | 1 |
| Ohta, M | 1 |
| Nokubo, M | 1 |
| Matsukura, M | 1 |
| Ikeda, T | 1 |
| Higashi, A | 1 |
| Matsuda, I | 1 |
| Morselli, PL | 1 |
| Franco-Morselli, R | 1 |
| Bar, S | 1 |
| Feller, N | 1 |
| Savir, H | 1 |
| Mares, P | 4 |
| Hlavatá, J | 1 |
| Lisková, K | 1 |
| Mudrochová, M | 1 |
| Mullenix, P | 1 |
| Tassinari, MS | 1 |
| Patterson, M | 1 |
| Heazelwood, R | 1 |
| Smithurst, B | 1 |
| Bauer, LA | 1 |
| Blouin, RA | 1 |
| Lowenthal, DT | 1 |
| Affrime, MB | 1 |
| van Boxtel, CJ | 1 |
| Rane, A | 2 |
| Brown, RD | 1 |
| Wilson, JT | 2 |
| Gerken, DK | 1 |
| Yeary, RA | 1 |
| Chiba, K | 1 |
| Ishizaki, T | 1 |
| Miura, H | 1 |
| Minagawa, K | 1 |
| Dilman, VM | 1 |
| Anisimov, VN | 2 |
| Schaeffer, DJ | 1 |
| Janardan, KG | 1 |
| Somani, SM | 1 |
| Easton, D | 1 |
| Sherman, D | 1 |
| Gex-Fabry, M | 1 |
| Balant-Gorgia, AE | 1 |
| Balant, LP | 1 |
| Seidl, J | 1 |
| Nováková, J | 1 |
| Nakashima, E | 1 |
| Matsushita, R | 1 |
| Iida, Y | 1 |
| Ohshima, T | 1 |
| Ichimura, F | 1 |
| Ciancio, SG | 1 |
| Koyama, H | 1 |
| Sugioka, N | 1 |
| Uno, A | 1 |
| Mori, S | 1 |
| Nakajima, K | 1 |
| Brumberg, JC | 1 |
| Nowak, LG | 1 |
| McCormick, DA | 1 |
| Tucha, O | 1 |
| Smely, C | 1 |
| Preier, M | 1 |
| Lange, KW | 1 |
| Baskin, SI | 1 |
| Leibman, AJ | 1 |
| Cohn, EM | 1 |
| Richey, DP | 1 |
| Bender, AD | 2 |
| Dil'man, VM | 1 |
| Illsley, NP | 1 |
| Lamartiniere, CA | 1 |
| James, RC | 1 |
| Franklin, MR | 1 |
| Hvidberg, EF | 1 |
| Dam, M | 1 |
| Jusko, WJ | 1 |
| Gretch, M | 1 |
| Post, A | 1 |
| Meier, JP | 1 |
| Higson, JE | 1 |
| Reichard, G | 1 |
| Hayes, MJ | 1 |
| Langman, MJ | 1 |
| Short, AH | 1 |
| McDonald, JW | 1 |
| Trescher, WH | 1 |
| Johnston, MV | 1 |
| Stanková, L | 1 |
| Kubová, H | 2 |
| Turski, W | 1 |
| Dziki, M | 1 |
| Parada, J | 1 |
| Kleinrok, Z | 1 |
| Cavalheiro, EA | 1 |
| Dowson, JH | 1 |
| Wilton-Cox, H | 1 |
| James, NT | 1 |
| Pollock, BG | 1 |
| Perel, JM | 1 |
| Kirshner, M | 1 |
| Altieri, LP | 1 |
| Yeager, AL | 1 |
| Reynolds, CF | 1 |
| Pryka, RD | 1 |
| Rodvold, KA | 1 |
| Erdman, SM | 1 |
| Ismail, R | 1 |
| Rahman, AF | 1 |
| Johnson, BD | 1 |
| Narayanan, AS | 1 |
| Pieters, HP | 1 |
| Page, RC | 1 |
| Chan, E | 1 |
| Ti, TY | 1 |
| Lee, HS | 1 |
| Ichikou, N | 1 |
| Ieiri, I | 2 |
| Higuchi, S | 2 |
| Hirata, K | 2 |
| Yamada, H | 2 |
| Aoyama, T | 2 |
| Srivastava, K | 1 |
| Barthwal, JP | 1 |
| Seth, PK | 1 |
| Hudson, SA | 1 |
| Farquhar, DL | 1 |
| Thompson, D | 1 |
| Smith, RG | 1 |
| Vorhees, CV | 1 |
| Rauch, SL | 1 |
| Hitzemann, RJ | 1 |
| Jahn, F | 1 |
| Kadiiska, M | 1 |
| Serbinova, E | 1 |
| Klinger, W | 1 |
| Stoytchev, T | 1 |
| el-Sayed, YM | 1 |
| Islam, SI | 1 |
| Kato, Y | 3 |
| Hirate, J | 3 |
| Sakaguchi, K | 3 |
| Ueno, M | 3 |
| Horikoshi, I | 3 |
| Ecobichon, DJ | 1 |
| D'Ver, AS | 1 |
| Ehrhart, W | 1 |
| Roy, D | 1 |
| Snodgrass, WR | 1 |
| Crowley, JJ | 1 |
| Cusack, BJ | 1 |
| Jue, SG | 1 |
| Koup, JR | 1 |
| Park, BK | 1 |
| Vestal, RE | 1 |
| Ensom, RJ | 1 |
| Nakagawa, RS | 1 |
| Houck, JC | 2 |
| Patel, YM | 1 |
| De Hesse, C | 1 |
| Jacob, R | 1 |
| Williams, MH | 1 |
| Gordon, P | 2 |
| Petty, WC | 1 |
| Karler, R | 1 |
| Ehrnebo, M | 1 |
| Agurell, S | 1 |
| Jalling, B | 1 |
| Boréus, LO | 1 |
| Babcock, JR | 1 |
| Trojaborg, W | 1 |
12 reviews available for phenytoin and Aging
| Article | Year |
|---|---|
Pharmacological and clinical aspects of antiepileptic drug use in the elderly.
Topics: Aged; Aging; Anticonvulsants; Epilepsy; Homes for the Aged; Humans; Nursing Homes; Phenytoin; Polyph | 2006 |
Theophylline reassessed.
Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents; | 1984 |
Clinical pharmacokinetics of antiepileptic drugs in adults.
Topics: Adult; Aging; Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Disease; Ethosuximide; Female; H | 1980 |
Plasma protein binding of phenytoin in health and disease: relevance to therapeutic drug monitoring.
Topics: Aging; Bilirubin; Blood Proteins; Burns; Disease; Drug Interactions; Fatty Acids, Nonesterified; Hum | 1980 |
Medications as risk factors for periodontal disease.
Topics: Aging; Alveolar Process; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvuls | 1996 |
Possible functions of taurine in the central nervous system.
Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Biological Transport, Active; Brain; Cats; Denerv | 1976 |
Pharmacokinetic consequences of aging.
Topics: Adult; Aged; Aging; Aminopyrine; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agent | 1977 |
Clinical pharmacokinetics of anticonvulsants.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Anticonvulsants; Carbamazepine; Child; Clonazepam | 1976 |
Plasma and tissue protein binding of drugs in pharmacokinetics.
Topics: Adrenal Cortex Hormones; Age Factors; Aging; Albumins; Animals; Anti-Bacterial Agents; Antibodies; A | 1976 |
An updated comparison of drug dosing methods. Part I: Phenytoin.
Topics: Aging; Algorithms; Bayes Theorem; Cost-Benefit Analysis; Humans; Phenytoin | 1991 |
Diphenylhydantoin and procainamide: normalization of suboptimal learning behavior.
Topics: Aging; Amino Acids; Animals; Brain; Learning; Male; Phenytoin; Procainamide; Rats; RNA | 1968 |
Molecular approaches to the drug enhancement of deteriorated functioning in the aged.
Topics: 1-Propanol; Aging; Amino Alcohols; Amphetamine; Animals; Brain; Cognition; Deoxyribonucleases; DNA; | 1971 |
3 trials available for phenytoin and Aging
| Article | Year |
|---|---|
Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy.
Topics: Adolescent; Adult; Age Factors; Aging; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Down | 2005 |
Potential of concentration monitoring data for a short half-life drug: analysis of pharmacokinetic variability for moclobemide.
Topics: Adult; Aged; Aged, 80 and over; Aging; Benzamides; Chromatography, Gas; Depressive Disorder; Drug In | 1995 |
Age-related alteration of carbamazepine-serum protein binding in man.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anticonvulsants; Child; Child, Preschool; Diethyl | 1999 |
69 other studies available for phenytoin and Aging
| Article | Year |
|---|---|
Patterns of antiepileptic drug use among elderly patients with epilepsy: 2004-2015.
Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Epilepsy; F | 2020 |
Phenytoin sodium-ameliorated gingival fibroblast aging is associated with autophagy.
Topics: Aging; Autophagy; Fibroblasts; Gingiva; Gingival Hyperplasia; Humans; Phenytoin; Voltage-Gated Sodiu | 2020 |
Changes in individual drug-independent system parameters during virtual paediatric pharmacokinetic trials: introducing time-varying physiology into a paediatric PBPK model.
Topics: Aging; Anticonvulsants; Bronchodilator Agents; Child; Child, Preschool; Clinical Trials as Topic; Hu | 2014 |
Modeling early-onset post-ischemic seizures in aging mice.
Topics: Aging; Analysis of Variance; Animals; Anticonvulsants; Brain; Chi-Square Distribution; Disease Model | 2015 |
Early-Onset Convulsive Seizures Induced by Brain Hypoxia-Ischemia in Aging Mice: Effects of Anticonvulsive Treatments.
Topics: Age of Onset; Aging; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Hippocampus; | 2015 |
Phenytoin half-life and clearance during maintenance therapy in adults and elderly patients with epilepsy.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anticonvulsants; Drug Admi | 2008 |
Dose adjustment of phenytoin for comedication in Japanese patients with epilepsy.
Topics: Adult; Aged; Aging; Algorithms; Anticonvulsants; Body Surface Area; Body Water; Body Weight; Drug In | 2009 |
Early postnatal exposure of rats to lamotrigine, but not phenytoin, reduces seizure threshold in adulthood.
Topics: Aging; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Female; Lamotrigine; Male; Phenyt | 2011 |
[Epilepsy in elderly].
Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies, | 2011 |
Protective role of endogenous catalase in baseline and phenytoin-enhanced neurodevelopmental and behavioral deficits initiated in utero and in aged mice.
Topics: Aging; Animals; Behavior, Animal; Brain; Catalase; Female; Litter Size; Male; Maternal-Fetal Exchang | 2012 |
Influence of coadministered antiepileptic drugs on serum zonisamide concentrations in epileptic patients: quantitative analysis based on suitable transforming factor.
Topics: Administration, Oral; Adolescent; Adult; Aging; Anticonvulsants; Biological Availability; Body Surfa | 2003 |
Introduction to the International Geriatric Epilepsy Symposium (IGES).
Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Brain Diseases; Epilepsy; Geriatrics; Homes for the | 2006 |
Epilepsy and antiepileptic drug use in elderly people as risk factors for dementia.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Anticonvulsants; Cohort Studies; Epilepsy; Female | 2007 |
Factors affecting antiepileptic drug pharmacokinetics in community-dwelling elderly.
Topics: Absorption; Adult; Aged; Aged, 80 and over; Aging; Anticonvulsants; Biological Availability; Carbama | 2007 |
Bioavailability and pharmacokinetics of phenytoin during pregnancy.
Topics: Aging; Biological Availability; Epilepsy; Female; Humans; Kinetics; Phenytoin; Pregnancy; Pregnancy | 1984 |
Vitamin K-dependent proteins and anticonvulsant medication.
Topics: Adolescent; Adult; Aging; Anticonvulsants; Calcium-Binding Proteins; Child; Child, Preschool; Drug I | 1983 |
Increased anticonvulsant effect of phenytoin in aging BDF1 mice.
Topics: Aging; Animals; Anticonvulsants; Brain; Electroshock; Female; Male; Mice; Phenytoin | 1984 |
Relative bioavailability of two different phenytoin preparations. Evidence for an age dependency.
Topics: Adolescent; Adult; Aging; Biological Availability; Child; Child, Preschool; Humans; Infant; Intestin | 1984 |
Presenile cataracts in phenytoin-treated epileptic patients.
Topics: Adult; Aging; Animals; Cataract; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Rodentia | 1983 |
Effects of carbamazepine and diphenylhydantoin on metrazol seizures during ontogenesis in rats.
Topics: Aging; Animals; Carbamazepine; Male; Pentylenetetrazole; Phenytoin; Rats; Rats, Inbred Strains; Seiz | 1983 |
Behavioral outcome after prenatal exposure to phenytoin in rats.
Topics: Aging; Animals; Behavior, Animal; Body Weight; Female; Learning; Motor Activity; Phenytoin; Pregnanc | 1983 |
Plasma protein binding of phenytoin in the aged: in vivo studies.
Topics: Aged; Aging; Bilirubin; Blood Proteins; Female; Humans; Male; Middle Aged; Phenytoin; Protein Bindin | 1982 |
Age and phenytoin kinetics in adult epileptics.
Topics: Adult; Aged; Aging; Epilepsy; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; | 1982 |
Cardiovascular drugs for the geriatric patient.
Topics: Aged; Aging; Antihypertensive Agents; Cardiovascular Agents; Cardiovascular Physiological Phenomena; | 1981 |
The formation of carbamazepine epoxide by rat liver microsomes: an investigation of the biphasic kinetic profile.
Topics: Aging; Animals; Carbamazepine; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; | 1981 |
Effect of anticonvulsants on in vitro prothrombin synthesis in adult and fetal rat liver.
Topics: Aging; Animals; Anticonvulsants; Female; In Vitro Techniques; Liver; Male; Phenobarbital; Phenytoin; | 1981 |
Apparent Michaelis-Menten kinetic parameters of phenytoin in pediatric patients.
Topics: Adolescent; Aging; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Hu | 1980 |
Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice.
Topics: Adenocarcinoma; Aging; Animals; Female; Leukemia, Experimental; Levodopa; Mammary Neoplasms, Experim | 1980 |
Multivariate statistical methods in toxicology: application to the analysis of outpatient clinical data for diphenylhydantoin and phenobarbital in the treatment of epilepsy.
Topics: Adolescent; Adult; Aging; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Sex | 1980 |
Differential action of phenytoin and carbamazepine on cortical interhemispheric responses in young but not in adult rats.
Topics: Aging; Analysis of Variance; Animals; Carbamazepine; Electric Stimulation; Epilepsy, Tonic-Clonic; M | 1993 |
Age-related changes in pharmacokinetic parameters of phenytoin after liver resection in rats.
Topics: Aging; Animals; Anticonvulsants; Hepatectomy; Liver; Male; Phenytoin; Rats; Rats, Wistar | 1995 |
Ionic mechanisms underlying repetitive high-frequency burst firing in supragranular cortical neurons.
Topics: Action Potentials; Aging; Animals; Calcium; Chelating Agents; Cycloleucine; Egtazic Acid; Female; Fe | 2000 |
Cognitive deficits before treatment among patients with brain tumors.
Topics: Adult; Aged; Aging; Anticonvulsants; Brain Edema; Brain Neoplasms; Cognition; Cognition Disorders; D | 2000 |
[Increase in longevity and a decrease in the frequency of tumors in C3H/Sn mice under the influence of fenformin and diphenin].
Topics: Aging; Animals; Female; Levodopa; Longevity; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Phenfo | 1979 |
Prenatal programming of hepatic monoamine oxidase by 5,5-diphenylhydantoin.
Topics: Aging; Animals; Female; Hormones; Liver; Male; Maternal-Fetal Exchange; Monoamine Oxidase; Phenytoin | 1979 |
The triphasic amphetamine lethal dose curve in mice and its possible relationship to drug metabolism.
Topics: Aging; Amphetamine; Animals; Anticonvulsants; Dextroamphetamine; Hexobarbital; In Vitro Techniques; | 1978 |
Clinical pharmacokinetics in infants and children.
Topics: Aging; Body Water; Carbamazepine; Child; Child, Preschool; Clindamycin; Dextropropoxyphene; Diazoxid | 1976 |
Plasma protein binding of drugs as a function of age in adult human subjects.
Topics: Adult; Aged; Aging; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Blood P | 1975 |
Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding.
Topics: Adult; Aged; Aging; Female; Humans; Male; Metabolic Clearance Rate; Phenobarbital; Phenytoin; Protei | 1975 |
Susceptibility of brain to AMPA induced excitotoxicity transiently peaks during early postnatal development.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 1992 |
Anticonvulsant action of lamotrigine during ontogenesis in rats.
Topics: Aging; Animals; Anticonvulsants; Epilepsy, Tonic-Clonic; Injections, Intraperitoneal; Lamotrigine; M | 1992 |
Age dependency of the susceptibility of rats to aminooxyacetic acid seizures.
Topics: Aging; Aminooxyacetic Acid; Animals; Anticonvulsants; Body Temperature; Brain; Carbamazepine; Clonaz | 1992 |
Lipopigment in rat hippocampal and Purkinje neurones after chronic phenytoin administration.
Topics: Aging; Animals; Body Weight; Hippocampus; Lipids; Male; Phenytoin; Pigments, Biological; Purkinje Ce | 1992 |
S-mephenytoin 4-hydroxylation in older Americans.
Topics: Aged; Aging; Aryl Hydrocarbon Hydroxylases; Black People; Chromatography, High Pressure Liquid; Crea | 1991 |
Michaelis-Menten pharmacokinetics of phenytoin in adult Malaysian patients.
Topics: Adolescent; Adult; Aging; Body Weight; Child; Female; Humans; Malaysia; Male; Phenytoin; Regression | 1990 |
Effect of cell donor age on the synthetic properties of fibroblasts obtained from phenytoin-induced gingival hyperplasia.
Topics: Adolescent; Adult; Aged; Aging; Cells, Cultured; Child; Collagen; Electrophoresis, Gel, Two-Dimensio | 1990 |
Population pharmacokinetics of phenytoin in Singapore Chinese.
Topics: Adolescent; Adult; Aged; Aging; Bayes Theorem; Body Weight; Child; Child, Preschool; China; Female; | 1990 |
Analysis of the factors influencing anti-epileptic drug concentrations--carbamazepine.
Topics: Aging; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Female; Huma | 1990 |
Analysis of the factors influencing anti-epileptic drug concentrations--valproic acid.
Topics: Adolescent; Adult; Aging; Aspartate Aminotransferases; Body Weight; Carbamazepine; Dose-Response Rel | 1990 |
In vivo and in vitro effect of phenytoin on rat hepatic mixed function oxidases.
Topics: Aging; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Animals, Newborn; Aryl Hydrocarbon H | 1990 |
Phenytoin dosage individualization--five methods compared in the elderly.
Topics: Aged; Aged, 80 and over; Aging; Dose-Response Relationship, Drug; Humans; Methods; Phenytoin | 1990 |
Prenatal phenytoin exposure decreases neuronal membrane order in rat offspring hippocampus.
Topics: Aging; Animals; Brain; Cell Membrane; Cerebellum; Cerebral Cortex; Diphenylhexatriene; Female; Hippo | 1990 |
Potentiation of the anticonvulsant action of clonazepam by phenytoin could be demonstrated in adult as well as young rats.
Topics: Aging; Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Ph | 1989 |
The influence of acute phenytoin administration on biotransformation and lipid peroxidation in the liver of rats of different ages.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aging; Animals; Biotransformation; Cytochrome P-450 CYP1A1; Cytochrom | 1989 |
Phenytoin Michaelis-Menten pharmacokinetics in Saudi patients.
Topics: Adolescent; Adult; Aging; Body Weight; Child; Child, Preschool; Female; Fluorescence Polarization; H | 1989 |
Factors causing age-dependent changes in phenytoin tissue and serum binding in rats.
Topics: Aging; Animals; Blood Proteins; Fatty Acids, Nonesterified; Female; Male; Phenytoin; Phospholipids; | 1988 |
Drug disposition and biotransformation in the developing beagle dog.
Topics: Acetaminophen; Aging; Animals; Biotransformation; Blood Proteins; Dogs; Female; Half-Life; Male; Pha | 1988 |
Phenytoin metabolic activation: role of cytochrome P-450, glutathione, age, and sex in rats and mice.
Topics: Aging; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Female; Glutathione; Male; Mice; | 1988 |
Aging and drug interactions. II. Effect of phenytoin and smoking on the oxidation of theophylline and cortisol in healthy men.
Topics: Adult; Aged; Aging; Half-Life; Humans; Hydrocortisone; Male; Oxidation-Reduction; Phenytoin; Smoking | 1988 |
Age-dependent changes in phenytoin tissue bindings in rats: comparison between in vivo and in vitro tissue-to-blood partition coefficients (Kp values) of phenytoin.
Topics: Aging; Animals; Body Water; Female; In Vitro Techniques; Male; Phenytoin; Pregnancy; Rats; Rats, Inb | 1987 |
Age-dependent changes in phenytoin tissue distribution in rats.
Topics: Aging; Animals; Blood Proteins; Female; Injections, Intravenous; Phenytoin; Pregnancy; Protein Bindi | 1987 |
Phenytoin absorption in adults: effect of aging.
Topics: Adult; Aged; Aging; Female; Humans; Intestinal Absorption; Male; Middle Aged; Phenytoin; Pilot Proje | 1985 |
Proposed mode of action of corticosteroids on the connective tissue.
Topics: Adrenal Cortex Hormones; Aging; Animals; Collagen; Hydrocortisone; Hydroxyproline; In Vitro Techniqu | 1965 |
The effect of ageing upon collagen metabolism.
Topics: Aging; Animals; Body Weight; Burns; Citrates; Collagen; Cycloheximide; Desoxycorticosterone; Glycine | 1967 |
Special problems in respiratory diseases.
Topics: Adrenal Cortex Hormones; Aged; Aging; Anti-Bacterial Agents; Anticoagulants; Asthma; Bronchodilator | 1974 |
The influence of aging on the activity of anticonvulsant drugs.
Topics: Acetazolamide; Aging; Animals; Blood-Brain Barrier; Carbon Dioxide; Carbonic Anhydrases; Cerebral Co | 1965 |
Age differences in drug binding by plasma proteins: studies on human foetuses, neonates and adults.
Topics: Adult; Age Factors; Aging; Ampicillin; Azides; Bilirubin; Blood Proteins; Dialysis; Female; Fetus; F | 1971 |
Incidence of gingival hyperplasia associated with Dilantin therapy in a hospital population.
Topics: Adolescent; Adult; Aged; Aging; Black or African American; Body Weight; Child; Child, Preschool; Fem | 1965 |
Focal spike discharges in children, a longitudinal study.
Topics: Adolescent; Aging; Central Nervous System Diseases; Cerebral Palsy; Cerebral Ventriculography; Child | 1966 |