phenytoin has been researched along with Aggression in 23 studies
Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Studies of the effects of phenytoin on aggression have produced equivocal results primarily because of a lack of (1) common objective criterion measures of aggressive acts across studies; (2) rigorous inclusion and exclusion criteria for selecting subjects; and (3) a nosologic basis for classifying different types of aggression." | 9.08 | The effects of phenytoin on impulsive and premeditated aggression: a controlled study. ( Barratt, ES; Felthous, AR; Kent, TA; Stanford, MS, 1997) |
| "Phenytoin is a widely used anticonvulsant drug that also reduces aggressive behavior." | 5.31 | Phenytoin inhibits isolation-induced aggression specifically in rats with low serotonin. ( Keele, NB, 2001) |
| "Adenosine is an inhibitor of neuronal activity in the brain." | 5.31 | Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. ( Aebischer, P; Boison, D; Déglon, N; Huber, A; Möhler, H; Padrun, V, 2001) |
| "Studies of the effects of phenytoin on aggression have produced equivocal results primarily because of a lack of (1) common objective criterion measures of aggressive acts across studies; (2) rigorous inclusion and exclusion criteria for selecting subjects; and (3) a nosologic basis for classifying different types of aggression." | 5.08 | The effects of phenytoin on impulsive and premeditated aggression: a controlled study. ( Barratt, ES; Felthous, AR; Kent, TA; Stanford, MS, 1997) |
| "Sodium phenobarbitone (20 and 70 mg/kg) had a significant anticonvulsant action against pentylenetetrazole-induced seizures, which persisted for 21 days of treatment." | 3.68 | Changes in seizure threshold and aggression during chronic treatment with three anticonvulsants and on drug withdrawal. ( File, SE; Wilks, LJ, 1990) |
| "Nortriptyline was reported in one study as superior for men with alcohol dependency on mean number of drinking days and on alcohol dependence, but not for severity of alcohol misuse or on the patient's or clinician's rating of drinking." | 2.46 | Pharmacological interventions for antisocial personality disorder. ( Duggan, C; Ferriter, M; Huband, N; Khalifa, N; Lieb, K; Stoffers, J; Völlm, BA, 2010) |
| "Phenytoin is a widely used anticonvulsant drug that also reduces aggressive behavior." | 1.31 | Phenytoin inhibits isolation-induced aggression specifically in rats with low serotonin. ( Keele, NB, 2001) |
| "Adenosine is an inhibitor of neuronal activity in the brain." | 1.31 | Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. ( Aebischer, P; Boison, D; Déglon, N; Huber, A; Möhler, H; Padrun, V, 2001) |
| "Diazepam was equally effective, and several times more potent than chlordiazepoxide." | 1.25 | Chlordiazepoxide and diazepam induced mouse killing by rats. ( Corcia, RM; Gay, PE; Lamon, S; Leaf, RC; Wnek, DJ, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (56.52) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Khalifa, NR | 1 |
| Gibbon, S | 1 |
| Völlm, BA | 2 |
| Cheung, NH | 1 |
| McCarthy, L | 1 |
| Khalifa, N | 1 |
| Duggan, C | 1 |
| Stoffers, J | 1 |
| Huband, N | 1 |
| Ferriter, M | 1 |
| Lieb, K | 1 |
| Barratt, ES | 3 |
| Felthous, AR | 3 |
| Stanford, MS | 3 |
| Helfritz, LE | 1 |
| Conklin, SM | 1 |
| Villemarette-Pittman, NR | 2 |
| Greve, KW | 2 |
| Adams, D | 2 |
| Houston, RJ | 2 |
| Kent, TA | 2 |
| Keele, NB | 1 |
| Huber, A | 1 |
| Padrun, V | 1 |
| Déglon, N | 1 |
| Aebischer, P | 1 |
| Möhler, H | 1 |
| Boison, D | 1 |
| Mathias, CW | 1 |
| Lion, JR | 1 |
| Rosenblatt, S | 1 |
| Schaeffer, D | 1 |
| Rosenthal, JS | 1 |
| Hadfield, MG | 2 |
| Rigby, WF | 1 |
| Monroe, RR | 1 |
| Weber, NE | 1 |
| Leaf, RC | 1 |
| Wnek, DJ | 1 |
| Gay, PE | 1 |
| Corcia, RM | 1 |
| Lamon, S | 1 |
| Bryant, SG | 1 |
| File, SE | 1 |
| Wilks, LJ | 1 |
| Aman, MG | 1 |
| Singh, NN | 1 |
| Edwards, VE | 1 |
| Zappoli, R | 1 |
| Papini, M | 1 |
| Maletzky, BM | 1 |
| Goldberg, JB | 1 |
| Kurland, AA | 1 |
| Maughs, SB | 1 |
| Krsiak, M | 1 |
| Steinberg, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Fluoxetine on Measures of Domestic Violence[NCT00011765] | Phase 2 | 104 participants (Actual) | Interventional | 2001-02-22 | Completed | ||
| Medication Development for Cocaine Dependence[NCT00249691] | Phase 3 | 180 participants (Anticipated) | Interventional | 2005-10-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for phenytoin and Aggression
| Article | Year |
|---|---|
Pharmacological interventions for antisocial personality disorder.
Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety; | 2020 |
Pharmacological interventions for antisocial personality disorder.
Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety; | 2020 |
Pharmacological interventions for antisocial personality disorder.
Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety; | 2020 |
Pharmacological interventions for antisocial personality disorder.
Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety; | 2020 |
Pharmacological interventions for antisocial personality disorder.
Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety; | 2010 |
Impulsive versus premeditated aggression: implications for mens rea decisions.
Topics: Aggression; Anticonvulsants; Consciousness; Criminal Law; Criminal Psychology; Humans; Impulsive Beh | 2003 |
Conceptual issues in the use of drugs for the treatment of aggression in man.
Topics: Adolescent; Adult; Aggression; Alcoholic Intoxication; Animals; Anti-Anxiety Agents; Anticonvulsants | 1975 |
Criminal psychopathology.
Topics: Adolescent; Adult; Aggression; Behavior; Crime; Criminal Psychology; Homicide; Humans; Juvenile Deli | 1970 |
Psychopharmacological aspects of aggression: a review of the literature and some new experiments.
Topics: Aggression; Amobarbital; Animals; Barbiturates; Bees; Behavior, Animal; Cats; Chlordiazepoxide; Chlo | 1969 |
7 trials available for phenytoin and Aggression
| Article | Year |
|---|---|
A comparison of anticonvulsants in the treatment of impulsive aggression.
Topics: Adult; Aggression; Anticonvulsants; Carbamazepine; Double-Blind Method; Female; Humans; Impulsive Be | 2005 |
The effects of phenytoin on impulsive and premeditated aggression: a controlled study.
Topics: Adult; Aggression; Anticonvulsants; Antisocial Personality Disorder; Cerebral Cortex; Cross-Over Stu | 1997 |
A double-blind placebo-controlled crossover study of phenytoin in individuals with impulsive aggression.
Topics: Adult; Aggression; Cerebral Cortex; Cross-Over Studies; Double-Blind Method; Electroencephalography; | 2001 |
Effects of diphenylhydantoin on child-abusing parents: a preliminary report.
Topics: Adult; Aggression; Behavior; Child; Child Abuse; Clinical Trials as Topic; Depression, Chemical; Fem | 1976 |
Anticonvulsants in the treatment of aggression.
Topics: Adult; Aggression; Anticonvulsants; Chlordiazepoxide; Chlorpromazine; Drug Therapy, Combination; Epi | 1975 |
A controlled trial of phenytoin in impulsive aggression.
Topics: Adult; Aggression; Antisocial Personality Disorder; Double-Blind Method; Humans; Impulsive Behavior; | 1991 |
Dilantin treatment of hospitalized cultural-familial retardates.
Topics: Adolescent; Aggression; Attention; Child; Child Behavior; Clinical Trials as Topic; Hospitalization; | 1970 |
10 other studies available for phenytoin and Aggression
| Article | Year |
|---|---|
Phenytoin inhibits isolation-induced aggression specifically in rats with low serotonin.
Topics: Aggression; Animals; Anticonvulsants; Fenclonine; Male; Motor Activity; Phenytoin; Rats; Rats, Sprag | 2001 |
Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy.
Topics: Adenosine; Adenosine Deaminase; Adenosine Kinase; Aggression; Animals; Brain; Cell Line; Cell Transp | 2001 |
Dopamine--adaptive uptake changes in striatal synaptosomes after 30 sec of shock-induced fighting.
Topics: Aggression; Animals; Corpus Striatum; Dopamine; Electroshock; Humans; Kinetics; Male; Phenytoin; Rat | 1976 |
Effect of fighting and diphenylhydantoin on the uptake of 3H-l-norepinephrine in vitro in synaptosomes isolated from retired male breeding mice.
Topics: Aggression; Animals; Brain; Electroshock; Humans; In Vitro Techniques; Kinetics; Male; Mice; Nerve E | 1975 |
Chlordiazepoxide and diazepam induced mouse killing by rats.
Topics: Aggression; Amphetamine; Animals; Behavior, Animal; Chlordiazepoxide; Diazepam; Dose-Response Relati | 1975 |
Changes in seizure threshold and aggression during chronic treatment with three anticonvulsants and on drug withdrawal.
Topics: Aggression; Animals; Anticonvulsants; Lorazepam; Male; Mice; Pentylenetetrazole; Phenobarbital; Phen | 1990 |
A critical appraisal of recent drug research in mental retardation: the Coldwater studies.
Topics: Aggression; Antipsychotic Agents; Attitude of Health Personnel; Discrimination Learning; Humans; Ins | 1986 |
Side effects of clonazepam therapy.
Topics: Adolescent; Adult; Aggression; Ataxia; Benzodiazepinones; Clonazepam; Drug Interactions; Epilepsy; E | 1974 |
[Treatment of partial epilepsies with a sultiamum containing combination].
Topics: Adolescent; Adult; Aggression; Anticonvulsants; Barbiturates; Caffeine; Child; Electroencephalograph | 1969 |
The episodic dyscontrol syndrome.
Topics: Adolescent; Adult; Aggression; Animals; Electroencephalography; Evaluation Studies as Topic; Humans; | 1973 |