Page last updated: 2024-10-21

phenytoin and Adenocarcinoma

phenytoin has been researched along with Adenocarcinoma in 14 studies

Adenocarcinoma: A malignant epithelial tumor with a glandular organization.

Research Excerpts

ExcerptRelevanceReference
"This trial explores SM-88 used with methoxsalen, phenytoin, and sirolimus (MPS) in pretreated metastatic pancreatic ductal adenocarcinoma (mPDAC) METHODS: Forty-nine patients were randomized to daily 460 or 920 mg oral SM-88 with MPS (SM-88 Regimen)."5.51A randomized phase II study of SM-88 plus methoxsalen, phenytoin, and sirolimus in patients with metastatic pancreatic cancer treated in the second line and beyond. ( Chung, V; Hartley, ML; Kim, DW; Kim, S; Noel, MS; Ocean, AJ; Philip, PA; Picozzi, VJ; Staszewski, H; Van Tornout, JM; Wang-Gillam, A; Wong, S, 2022)
"Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been associated with some drugs, particularly anticonvulsants such as phenytoin."3.74[Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy]. ( Fernández, FA; Garcés, FJ; Pintor, E; Quesada, R, 2007)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19906 (42.86)18.7374
1990's2 (14.29)18.2507
2000's4 (28.57)29.6817
2010's1 (7.14)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Noel, MS1
Kim, S1
Hartley, ML1
Wong, S1
Picozzi, VJ1
Staszewski, H1
Kim, DW1
Van Tornout, JM1
Philip, PA1
Chung, V1
Ocean, AJ1
Wang-Gillam, A1
Fidan, E1
Fidan, M1
Ozdemir, F1
Kavgaci, H1
Aydin, F1
Camartin, C1
Reinhart, WH1
Kuhn, M1
Brickell, K1
Porter, D1
Thompson, P1
ROSENBLUM, I1
STEIN, AA1
Elkiran, ET1
Altundag, K1
Beyazit, Y1
Guler, N1
Kars, A1
Fernández, FA1
Pintor, E1
Quesada, R1
Garcés, FJ1
Anisimov, VN2
Ostroumova, MN1
Dil'man, VM1
Dilman, VM1
Schuetz, EG1
Beck, WT1
Schuetz, JD1
Wan, HH1
Thatcher, N1
Mullen, PW1
Smith, GN1
Wilkinson, PM1
Lackner, TE1
Wilkinson, HA1
Hendricks, GL1
Barnes, WT1
Hood, HL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Phase 2/3 Multi-Center Study of SM-88 in Subjects With Pancreatic Cancer Whose Disease Has Progressed or Recurred[NCT03512756]Phase 2/Phase 3132 participants (Actual)Interventional2018-03-27Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for phenytoin and Adenocarcinoma

ArticleYear
A randomized phase II study of SM-88 plus methoxsalen, phenytoin, and sirolimus in patients with metastatic pancreatic cancer treated in the second line and beyond.
    Cancer medicine, 2022, Volume: 11, Issue:22

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Humans; Methoxsalen; Pancreatic Neop

2022

Other Studies

13 other studies available for phenytoin and Adenocarcinoma

ArticleYear
Phenytoin- and cranial radiotherapy-induced toxic epidermal necrolysis treated with combination therapy: systemic steroid and intravenous immunoglobulin.
    Medical oncology (Northwood, London, England), 2012, Volume: 29, Issue:2

    Topics: Adenocarcinoma; Anti-Inflammatory Agents; Anticonvulsants; Brain Neoplasms; Combined Modality Therap

2012
[Brain irradiation and phenytoin: a dangerous liaison?].
    Praxis, 2003, Feb-26, Volume: 92, Issue:9

    Topics: Adenocarcinoma; Adult; Aged; Anticonvulsants; Brain Neoplasms; Drug Eruptions; Female; Glioblastoma;

2003
Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports.
    British journal of cancer, 2003, Aug-18, Volume: 89, Issue:4

    Topics: Adenocarcinoma; Administration, Oral; Aged; Anticonvulsants; Antimetabolites, Antineoplastic; Breast

2003
PREFERENTIAL DISTRIBUTION OF DIPHENYLHYDANTOIN IN PRIMARY HUMAN BRAIN TUMORS.
    Biochemical pharmacology, 1963, Volume: 12

    Topics: Adenocarcinoma; Animals; Astrocytoma; Brain Neoplasms; Ependymoma; Humans; Mammary Neoplasms, Animal

1963
Fluorouracil-induced neurotoxicity presenting with generalized tonic-clonic seizure.
    The Annals of pharmacotherapy, 2004, Volume: 38, Issue:12

    Topics: Adenocarcinoma; Anticonvulsants; Antimetabolites, Antineoplastic; Fluorouracil; Humans; Male; Middle

2004
[Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy].
    Actas dermo-sifiliograficas, 2007, Volume: 98, Issue:7

    Topics: Adenocarcinoma; Aged; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Combined Modality Therapy;

2007
[Inhibition of the blastomogenic effect of 7,12-dimethylbenz(a)anthracene in female rats by buformin, diphenin, a polypeptide pineal extract and L-DOPA].
    Biulleten' eksperimental'noi biologii i meditsiny, 1980, Volume: 89, Issue:6

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Adenofibroma; Animals; Antineoplastic Agents; Benz

1980
Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice.
    Gerontology, 1980, Volume: 26, Issue:5

    Topics: Adenocarcinoma; Aging; Animals; Female; Leukemia, Experimental; Levodopa; Mammary Neoplasms, Experim

1980
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
    Molecular pharmacology, 1996, Volume: 49, Issue:2

    Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, No

1996
Lack of effect of immunotherapy with BCG and Corynebacterium parvum on hepatic drug hydroxylation in man.
    British journal of cancer, 1979, Volume: 39, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Bacterial Vaccines; BCG Vaccine; Female; Humans; Immunotherapy; Kidney

1979
Interaction of dexamethasone with phenytoin.
    Pharmacotherapy, 1991, Volume: 11, Issue:4

    Topics: Adenocarcinoma; Brain Edema; Brain Neoplasms; Dexamethasone; Drug Interactions; Humans; Male; Metabo

1991
Epileptic pain. An uncommon manifestation with localizing value.
    Neurology, 1973, Volume: 23, Issue:5

    Topics: Adenocarcinoma; Adult; Brain Neoplasms; Cerebral Angiography; Diazepam; Epilepsy; Female; Humans; Ma

1973
Seven-year "cure" of lung cancer with metastasis to the brain.
    JAMA, 1972, Apr-03, Volume: 220, Issue:1

    Topics: Adenocarcinoma; Brain Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Phe

1972